10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000072840 ---------------------------------------------------------MADGFSTLVNKVTASLSSDESKILLYLCTDLFNNSCVE-ELRGDLLAFAQQNPNQAGQPHSGN T_rubripes_ENSTRUP00000032169 ------------------------------------------------------VAYTDMDQLQTINQVVEELSSSERTKLLYLCGSFETEPSTE-SLKELLGR-------KVLHHDTGQ O_latipes_ENSORLP00000020363 -------------------------------------------------------LDHQRNHLYYINKIVEALSSSECRKLLFLCDSTSADSSVQ-SVRETLKL-------QVTCHDNAS G_aculeatus_ENSGACP00000008246 ------------------------------------------------------MALPDQFQLQAIQQTAEALDGRERSRLFYLCGVTDVDNTAG-CVEDVLKS-------RVIRHQGED T_nigroviridis_ENSTNIP00000019557 -------------------------------------------------------------PLQTIHQVVEELDGGERSRLLYLCQSPETDTSAE-ALKEILG--------RVLLHDSGQ C_familiaris_ENSCAFP00000017879 -------------------------------------------------------MTLYRMSAEVIHQVEEALDEDEKEMLLFLCRDVAADVAPL-TVRDLLDI-------LSERGELSA M_mulatta_ENSMMUP00000037902 ------------------------------------------------------------MSAEVIHQVEEALDTDEKEMLLFLCRDVAVDVVPP-NVRDLLDI-------LRERGKLSV E_caballus_ENSECAP00000018899 --------------------------------------------------------TLFRMSAEVIHQVEEALDEDEKEMLLFLCRDVAADVAPL-NVRDLLDI-------LRERGNLSS P_pygmaeus_ENSPPYP00000014600 ------------------------------------------------------------MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPP-NVRDLLDI-------LRERGKLSV H_sapiens_ENSP00000312455 ------------------------------------------------------------MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPP-NVRDLLDI-------LRERGKLSV O_cuniculus_ENSOCUP00000009525 ------------------------------------------------------------MSAEVIHQVEEALDEDEKETLLFLCRDVTADAVPP-NVRELLDV-------LSEQGKLSV P_troglodytes_ENSPTRP00000048882 ------------------------------------------------------------MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPP-NVRDLLDI-------LRERGKLSV R_norvegicus_ENSRNOP00000016730 -------------------------------------------------------MALSTVSAEVIHQVEESLDEDEKEMMLFLCRDVTENLAPP-NVRDLLDC-------LSERGQLSF B_taurus_ENSBTAP00000014607 -------------------------------------------------------MTLYRMSAEVIHQVEEALDEEEKDTLLFLCRDVAADVVPL-NVRDLLDI-------LRERGKLSS G_gallus_ENSGALP00000013394 -------------------------------------------------------MTKCQVPAVLIHQIEEELDKEEVDMMVFLCRDLAPDLATA-GLRELLGA-------LNERDKLSL M_musculus_ENSMUSP00000095329 -------------------------------------------------------MAQSPVSAEVIHQVEECLDEDEKEMMLFLCRDVTENLAAP-NVRDLLDS-------LSERGQLSF T_guttata_ENSTGUP00000010647 ------------------------------------------------------------VPAFLIHQIQEELDKDEEEMMVFLCRDLAPDLATA-DLKEILVA-------LNEREKLTP M_domestica_ENSMODP00000036253 ------------------------------------------------------------MSAQVIHQVEEELDEDEKEVILFLCRDLAPDLTTKLDLRDLLCT-------LNDKGKLSP O_anatinus_ENSOANP00000007114 -------------------------------------------------------MSVSRVAAAVIQQVEEELDEEEKETLVFLCRDLAPDLPSA-DVRELLRA-------LNDRDQLTL A_carolinensis_ENSACAP00000001663 -------------------------------------------------------MTVYRVPARLLHQIEQELDAEEKETMVFLCQDLVPNLPGL-DVQGLLVA-------LNEREMLTP M_domestica_ENSMODP00000036251 -----------------------------------------------------MEDNSKIKFNQQLLSINEKLEPEEIEALKFLCSDLISPRNLE-DIESGHQLF-QKFMDEDLLNEGDY G_gallus_ENSGALP00000013506 -----------------------------------------LKSFKPHWISSNMEDDDSLQFRQLLLLIDEGLGAEDVAALKFLCTDLIPFRKLE-SVQSAMDIF-QLLIDEDYLNEEDT X_tropicalis_ENSXETP00000008971 -----------------------------------------------------------MDFNSMLLSIDDGLGREDIEALKFLCRDVLRKNKLL-SVRSGQELF-QQLMTEDLINEDNF G_gallus_ENSGALP00000013571 ---------------------------------------------------------MSSDFRKLLFDISEALATEELAALKFLSLEHVPVRKQE-DTEEPKAFF-EVLKEKGMIEVEDL A_carolinensis_ENSACAP00000001629 -------------------------------------------------------------FRQILLAIDENLGKEDVDAMKFLCSDFISTKHLE-GVETAQDIF-QLLINRNLLSKEDT G_aculeatus_ENSGACP00000016969 -----------------------------------------------------------MD-RLKLSRIDEDLESSEVASLCFLCRDVLARKRLE-GINNARDLF-LRLEENGLLE--NN R_norvegicus_ENSRNOP00000016613 -----------------------------------------------------------MDFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQE-SINDVLVLF-QRLQEEGMLEEDNL T_nigroviridis_ENSTNIP00000010722 -----------------------------------------------------------MD-LQLLSRICEQLDSQEVASLCFLCREAVSKKSLE-GINDARGLF-KKLADQCLLE--NN P_pygmaeus_ENSPPYP00000014602 ------------------------------------------MKSQGQHWCSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCVGLVPNKKLE-KSSSASDVF-EHLLAEDLLSEEDP E_caballus_ENSECAP00000004055 -----------------------------------------------------------MNFNSCLYNIGEQLDSDELASLKFLSLDHIPQRKQE-PIQDALMLF-QRLQEKRLLEESNL E_caballus_ENSECAP00000021726 ------------------------------------------MTSQGQNLNSSSDDNCTMDFRQKLLFIDSHLGDQDVERLRFLCRDCVSHKKLE-KSSSALEIF-NHLLAEDLLREEDS H_sapiens_ENSP00000286186 ------------------------------------------MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLE-KSSSASDVF-EHLLAEDLLSEEDP M_mulatta_ENSMMUP00000037892 VEGGRRARVVTESKRNFFLGACPTPFPTEHVELGRLGGSETAMVPGKGGADYILLPFEEMDFNRNLYDIGEQLDSEELASLKFLSLDCIPQRKQE-PIKDALMLF-QRLQEKRMLEENNL T_guttata_ENSTGUP00000010625 ------------------------------------------------------------DFRKLLFEVSEALVTEELSALKFLSLDHVPRRKLE-AIHEPKAFF-EVLQEKDMIGAGNL G_gorilla_ENSGGOP00000010692 ------------------------------------------------------------MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPP-NVRDLLDI-------LRERGKLSV P_troglodytes_ENSPTRP00000021879 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQE-PIKDALMLF-QRLQEKRMLEESNL O_anatinus_ENSOANP00000001054 ---------------------------------------------------------------XLLFSIGEELAADDLEALKFLCLDLIPLKKQE-TIQDALGLF-RLLQEKGMLEEGKL H_sapiens_ENSP00000351273 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQE-PIKDALMLF-QRLQEKRMLEESNL G_aculeatus_ENSGACP00000005791 -----------------------------------------------------------MHFQKLLFDIGKALSGEEVKALAFLCTDILG-RNLS-SVESASGLF-SRLRDQGFLSAEQP P_troglodytes_ENSPTRP00000048878 ------------------------------------------MKSQGQHWCSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVP-KKLE-KSSSASDVF-EHLLAEDLLSEDDP O_anatinus_ENSOANP00000006351 -----------------------------------------------------------MDFHRLLFSIGEELAADDLEALKFLCLDLIPRKKQE-NIQDALGLF-RLLQEKGMLEEGKL T_rubripes_ENSTRUP00000024467 -----------------------------------------------------------MD-LRLLSQIDAQLDSLEVAALCFLCRDAVSPKSRE-GITDARGLF-KKLHEKRLLE--NS B_taurus_ENSBTAP00000038128 -----------------------------------------------------------MALTQCLYNIGEQLGSDDLAALKFLSRDHIPYRKQE-PIKDALMLF-QRLQEKRMLEENNL M_musculus_ENSMUSP00000027189 -----------------------------------------------------------MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQE-TIEDAQKLF-LRLREKGMLEEGNL C_familiaris_ENSCAFP00000017933 ------------------------------------------MTSQAQSLTFRSDDNCQSSFRGKLLTIDSKLEIQDVEGLKFLCRDFVSHKKLE-KSNSASDIF-DHLLAEELLSEEDP T_nigroviridis_ENSTNIP00000001216 ---------------------------------------------------------------------------------------------------SAYQLF-LSLCDQDHLSEERP T_guttata_ENSTGUP00000010628 -------------------------------------------------------------FRQQLFLISENLVTEDVAALKFLCTDLLHLRKLE-GVKLATDIF-RLLMAQEYLNAEDT G_gorilla_ENSGGOP00000000205 ---------------------------------------------------YILLPFEKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQE-PIKDALMLF-QRLQEKRMLEESNL C_familiaris_ENSCAFP00000017899 -----------------------------------------------------------MDFSKCLYNIGEQLDSDELASLKFLSLDYIPQKKQE-PIKDPLMLF-QRLQEKRMLEESNL M_domestica_ENSMODP00000036247 -----------------------------------------------------------MDFHTFLYGIAEEIDSADLASLKFLCLDQIPLKKQQ-HIKDALVLF-QTLEERGLLEEDNL G_gallus_ENSGALP00000013591 -----------------------------------------------------------MEFSQLLFVISEALDRTELASLKFLSLEHVTVRKRE-DIEEPKAFF-QALQEKGMIEVGDL T_rubripes_ENSTRUP00000044662 ---------------------------------------------------------CNMDFQARLLKVGNDLRKDEVRALVFLCSDILGCNPA--AVQSAGDLF-SRLSDQDHLSEEQP O_latipes_ENSORLP00000014046 -----------------------------------------------------------MD-RRTLSRIDDELNSEEVAELCFLCTDFIPRKRLE-GISSAKDLF-LKLEDATLL---DS P_pygmaeus_ENSPPYP00000014606 -----------------------------------------------------------MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQE-PIKDALMLF-QRLQEKRMLEESNL C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------EFRLLLHQICEGLTGENVSMMKFLCKDAIPRSR---ELETALDFM-EYFEAKGWIQEGDL G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095527 ------------------------------------------------------------MDPQIFHEIDENLTSGDVDQLKFLCLDFIPKRRLE-SVTDAKDLI-LRLDEQGLLE--DE A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037898 -----------------------------------------------------------------------------------------------------MRI---------------- E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075318 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358327 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000076913 ---------------------------------------------------MDEEMDMDMCFQRALLRVQESLSADELQDLLFLCSDLLCSRDLN-TVSSGRQLF-TLLQNQDLLSLEDP O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002508 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075645 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000016642 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000004858 ------------------------------------------MASPSQSLNSTLDDNRRVNFREKLLIIDLSLENRDVECLKFLCQDYITLGKLE-KCRRALDIF-EYLLQQELLSEEDP G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011503 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000019984 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000265164 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006164 -------------------------------ALVESGTVGDWVTVPGEGNGYXXXXXXXXXXXXXXXXXXEQLDSELL--LKF-ELDYIPQRKQE-PIQDALMLF-QRLQEKRMLEENNL O_latipes_ENSORLP00000015114 --------------------------------------------------------RSVTQKCGMQKRDAEALRNCSVCLLKDLVVDEL--------------LI-QALVKDGILTQN-- C_intestinalis_ENSCINP00000011493 ------------------------------------------------------MDPHPADFPEPPPQPRITLRSDTVDSSVF-------------------------------HDDDNL 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000072840 ALLMELMFQMKRYDLLRKVFGT-NKQQVEGIL----RKERVISDY--------------------------------R------------------------------------VLMADV T_rubripes_ENSTRUP00000032169 LLLGELMVRLRRFDILRKVCKT-TRDEVERTL----SSRHFVPKF--------------------------------R------------------------------------VLMANI O_latipes_ENSORLP00000020363 QFLAEVIWRMGRYDILKELFTL-SRNAVEQTL----ENRQVLSKF--------------------------------R------------------------------------VLMANI G_aculeatus_ENSGACP00000008246 QFLPELLLQLGRFDILKEVYKT-SRDEVEKAL----THRRVLPSF--------------------------------K------------------------------------VLMANI T_nigroviridis_ENSTNIP00000019557 LMLRELLVRLRRFDILKKVCQT-SRDEAERIL----SVRHFVPSF--------------------------------R------------------------------------VLMANI C_familiaris_ENSCAFP00000017879 MGLAELLYRVRRFDLLKRIFKM-DRRAVEAHLL---RHPRLISDY--------------------------------R------------------------------------VLMTEI M_mulatta_ENSMMUP00000037902 GDLAELLYRVRRFDLLKRILKM-DRKAVETHLL---RNPHLVSDY--------------------------------R------------------------------------VLMAEI E_caballus_ENSECAP00000018899 GGLAELLYRVRRFDLLKRILKM-DKTAVEAHLR---RHPRLVSDY--------------------------------R------------------------------------VLMTEI P_pygmaeus_ENSPPYP00000014600 GDLAELLYRVRRFDLLKRILKM-DRKAVETHLL---RNPHLVSDY--------------------------------R------------------------------------VLMAEI H_sapiens_ENSP00000312455 GDLAELLYRVRRFDLLKRILKM-DRKAVETHLL---RNPHLVSDY--------------------------------R------------------------------------VLMAEI O_cuniculus_ENSOCUP00000009525 VDLAELLYRVRRFDLLKRILKM-DKAAVEAHLH---RHPHLVSDY--------------------------------R------------------------------------VLMTEI P_troglodytes_ENSPTRP00000048882 GDLAELLYRVRRFDLLKRILKM-DRKAVETHLL---RNPHLVSDY--------------------------------R------------------------------------VLMAEI R_norvegicus_ENSRNOP00000016730 AALAELLYRVRRFDLLKRILKT-DKAAVEDHLC---RSPHLVSDY--------------------------------R------------------------------------VLLMEI B_taurus_ENSBTAP00000014607 VSLAELLYRVRRFDLLKRVLNM-DTPTVEALLR---KHPHLISDY--------------------------------R------------------------------------VLMMEI G_gallus_ENSGALP00000013394 LGLSELLYRVKRFDLLRRILKT-EKTTVEANLT---RNPRLVPDY--------------------------------R------------------------------------VLMVEI M_musculus_ENSMUSP00000095329 ATLAELLYRVRRFDLLKRILKT-DKATVEDHLR---RNPHLVSDY--------------------------------R------------------------------------VLLMEI T_guttata_ENSTGUP00000010647 VGLSELLYRVKRFDLLRRILNT-EKATVEAHLA---RSLRLIPDY--------------------------------R------------------------------------VLMVEI M_domestica_ENSMODP00000036253 AGLAELLYRVRRFDLLKRIMKT-DKASVEASLI---RYPKLVSDY--------------------------------R------------------------------------VLMTQL O_anatinus_ENSOANP00000007114 AALSELLYRVKRFDLLKRILKT-ERATVEANLI---RNPRLVSDY--------------------------------R------------------------------------VLMAEL A_carolinensis_ENSACAP00000001663 SYLAELLYRLKRFDLLKKILSV-GRTTVEAQLA---RHPLMLPKY--------------------------------R------------------------------------VLMTEI M_domestica_ENSMODP00000036251 FLVAELLFLIKHHNLL-QKIGY-TKEKVKKEL----SSKRKISSY--------------------------------R------------------------------------VMLYNL G_gallus_ENSGALP00000013506 FLLAELLYRIKYHSLL-SKLGY-TKEKVQECL----HEKGKVSPY--------------------------------R------------------------------------QMLYEL X_tropicalis_ENSXETP00000008971 FLLKELLYIINHHSLL-RNLGT-NKEKVQKAL----PRQGRISPY--------------------------------R------------------------------------QMLYQL G_gallus_ENSGALP00000013571 FFLKELLYRINRIDLLASHLGS-SREEMERELQV--PGKAKVSAY--------------------------------R------------------------------------QLLYGI A_carolinensis_ENSACAP00000001629 FIVAELLYRIKCHFLL-QKIGY-TQQKVEHNL----FHIRNVSEY--------------------------------R------------------------------------QMLYEI G_aculeatus_ENSGACP00000016969 SFLFELLQTIRRTDLL-NLLES-DSSPPEEA-----DANPILSDY--------------------------------R------------------------------------VMLYRV R_norvegicus_ENSRNOP00000016613 SFLKELLFHISRRDLLSRVLKS-SPEEMVRELQV--LGKAQVSAY--------------------------------R------------------------------------VMLFKL T_nigroviridis_ENSTNIP00000010722 SFLRQLLQTIRREDLL-RLLGA-DNRQLMET-----DASPLLSGY--------------------------------S------------------------------------VMLYNI P_pygmaeus_ENSPPYP00000014602 FFLAELLYIIRQKKLL-QHLSY-TKEEVEGLL----PTRQRVSLF--------------------------------R------------------------------------NLLYEL E_caballus_ENSECAP00000004055 SFLKELLFRINRLDLLTTELDT-SKEEMERELQS--PGRAQISAY--------------------------------R------------------------------------VMLFQI E_caballus_ENSECAP00000021726 FFLAELLYIIKQKSLL-CHLCY-TKEQVESLL----PARRRVSLF--------------------------------R------------------------------------NLLYEL H_sapiens_ENSP00000286186 FFLAELLYIIRQKKLL-QHLNC-TKEEVERLL----PTRQRVSLF--------------------------------R------------------------------------NLLYEL M_mulatta_ENSMMUP00000037892 SFLKELLFRINRLDLLTTYLNT-RKEEMERELQA--PGRAQISAY--------------------------------R------------------------------------VMLYQI T_guttata_ENSTGUP00000010625 FFLKELLYRIHRIDLLSTPLGC-SREEMERELQL--PGRAQVSAY--------------------------------R------------------------------------QLLYGI G_gorilla_ENSGGOP00000010692 GDLAELLYRVRRFDLLKRILKM-DRKAVETHLL---RNPHLVSDY--------------------------------R------------------------------------VLMAEI P_troglodytes_ENSPTRP00000021879 SFLKELLFRINRLDLLITYLNT-RKEEMERELQT--PGRAQISAY--------------------------------R------------------------------------VMLYQI O_anatinus_ENSOANP00000001054 SFLKELLFRIHRIDLLKAHLGT-SHGDVERELEE--PGRAQVSAY--------------------------------R------------------------------------ITTETI H_sapiens_ENSP00000351273 SFLKELLFRINRLDLLITYLNT-RKEEMERELQT--PGRAQISAY--------------------------------R------------------------------------VMLYQI G_aculeatus_ENSGACP00000005791 HLLTELLIIIQRVRLT-RDVDL-PA-----------EPSSLISPY--------------------------------R------------------------------------KMLYNL P_troglodytes_ENSPTRP00000048878 FFLAELLYIIRQKKLL-QHLNY-TKEEVERLL----PTRQRVSLF--------------------------------R------------------------------------NLLYEL O_anatinus_ENSOANP00000006351 FFLKELLFRIHRIDLLTSHLRT-SQEDVARELEE--PGRAQVSAYS-------------------------------R------------------------------------VLLFTL T_rubripes_ENSTRUP00000024467 SFLSQLLHTIHRKDLL-CLLEA-DSSQPEET-----DARPLLSEY--------------------------------R------------------------------------VMLYKL B_taurus_ENSBTAP00000038128 SFLKELLFRVNRLDLLLNYLYT-SEEEMKRELQI--PGRAQISAY--------------------------------R------------------------------------ILLFQI M_musculus_ENSMUSP00000027189 SFLKELLFHISRWDLLVNFLDC-NREEMVRELRD--PDNAQISPY--------------------------------R------------------------------------VMLFKL C_familiaris_ENSCAFP00000017933 FFLAELLYIIKQNSLL-RYLNQ-SKEQVESLL----PTRRRVSLF--------------------------------R------------------------------------NLLYEL T_nigroviridis_ENSTNIP00000001216 HLLSELLSIIQRTRLL-RDLDL-RSS----------ATSNLISAY--------------------------------R------------------------------------KLLYSL T_guttata_ENSTGUP00000010628 FLLAELLYRIRCHSLL-KKIGY-TKEKVQEHL----SEKGRISPY--------------------------------R------------------------------------QMLYEL G_gorilla_ENSGGOP00000000205 SFLKELLFRINRLDLLITYLNT-RKEEMERELQT--PGRAQISAY--------------------------------R------------------------------------VMLYQI C_familiaris_ENSCAFP00000017899 FFLKELLFRINRLDLLMTYLDT-SKEDMQQELQI--PGRAQISAY--------------------------------R------------------------------------VMLFQI M_domestica_ENSMODP00000036247 FFLKELLFRINRIDLLNEPLNT-KGPEMERELQV--PNKARISPY--------------------------------RLHLHTTIWPFRDNWTCRITLSVSFTSRTKQLLSVMVILLFNL G_gallus_ENSGALP00000013591 FFLKELLYRINRIDLLASYLGS-SREEMERELQV--PGRARVSPF--------------------------------R------------------------------------YLLFQL T_rubripes_ENSTRUP00000044662 HLLVELLGIIQRTKLL-RDHNL-PRT----------GAQDLISPYSCKS----------------------------R------------------------------------KLLYSL O_latipes_ENSORLP00000014046 SYLTQLFRTIHREDLV-RQVQN-GSRQAEEA-----DAVPSLSDY--------------------------------R------------------------------------VMLYSI P_pygmaeus_ENSPPYP00000014606 SFLKELLFRINRLDLLITYLNT-RKEEMERELQT--PGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWWRVDHILIR------------------------------------VMLYQI C_intestinalis_ENSCINP00000024485 GFLAEVLYRINRHDLLKLLPGVKNRRDYEENFQ---AQQNNFTTY--------------------------------R------------------------------------VVCFML G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095527 LLFPELLITIGRIDLL-EILKK-SKEEVKRNLLRCDNSRKGVSAY--------------------------------R------------------------------------KMLLKI A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037898 ------------------------------------PTKWFYLFF--------------------------------------------------------------------------- E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075318 -------------------------------------------------------------------------------------------------------------------MADQL C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------------------------------------------------------------MDCVGW P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------------------------------------------------------------MDCVGW H_sapiens_ENSP00000358327 ------------------------------------------------------------------------------------------------------------------MDCVGW B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000076913 SLLIELLSITKRTRLMRSLQSD-ACMQTSGTADQPLQQQQRISRY--------------------------------R------------------------------------QFLYEL O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002508 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075645 --------------------------------------------------------------------------------------------------------------------MDKT X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000016642 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000004858 VFLAELLYIIEQKILL-KHLDY-TKEQVECWL----QTRRRVSHF--------------------------------R------------------------------------NLLYEL G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011503 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000019984 -------------------------------------------------------------------------------------------------------------------MDKEA H_sapiens_ENSP00000265164 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006164 AFLKELLFRIHRLDLLSTLLGT-SKEEMVTELQI--PGRAHISAY--------------------------------X------------------------------------XXXXXX O_latipes_ENSORLP00000015114 ------------------------------------------------------------------------------------------------------------------MAESIM C_intestinalis_ENSCINP00000011493 FSMDDAVEQPDSFDAV--------------------PPNSYPSPN------------------------------------------------------------------------SSL 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000072840 SENLDKEDLQSLIFLLSSILPKE--------RS--TRAT--------S-FLDVVVELEKLNEVSCEKLDFLEKCLKNIRRNDLVKKIQAYR------------NRG-------------- T_rubripes_ENSTRUP00000032169 SEDLASEDLNSLKFLLSQVLPRE--------KL--EKSK--------S-FLDVVIELEKLDKVSSQSVDLVEECLVGIGRLDLTRKVSAYK------------KSD-------------- O_latipes_ENSORLP00000020363 SEDLDTEDLEQILFLLSTTLPRE--------KR--DAKQ--------S-FLDVIVELEKLDLVSPERVDMVEECLRNICRIDLAKKVSTYK------------KTV-------------- G_aculeatus_ENSGACP00000008246 NEDMAKEDLNSVKFLLGQTLSRE--------KM--ENAQ--------S-FLDVIIELEKLDIVSPGRVDLVEECLRNIGRVDLAKKVTAYK------------MSG-------------- T_nigroviridis_ENSTNIP00000019557 SQALSSENLEDIKFLLSTTLPRE--------KL--GKSK--------S-FLDVVTELEKLDKVSPQRVDLMEKCLRSIGRVDLAKKVAAYR------------NPA-------------- C_familiaris_ENSCAFP00000017879 GDDLDKSDVSSLIFLMRDHMGRN--------KV--AKDK--------S-FLDLVIELEKLNLIAPDQLDLLEKCLKNIHRIDLKTKIQKYK------------QSA-------------- M_mulatta_ENSMMUP00000037902 GEDLDKSDVSSLIFLMKDYMGRG--------KI--SKEK--------S-FLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYK------------QSA-------------- E_caballus_ENSECAP00000018899 GEDLDKSDVSSLIFLMRDYMGRS--------KI--AKDK--------S-FLDLVIELEKLNLLAPDQLDLLEKCLKNIHRIDLKTKIQKYR------------QSA-------------- P_pygmaeus_ENSPPYP00000014600 GEDLDKSDVSSLIFLMKDYMGRG--------KI--SKEK--------S-FLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYK------------QSV-------------- H_sapiens_ENSP00000312455 GEDLDKSDVSSLIFLMKDYMGRG--------KI--SKEK--------S-FLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYK------------QSV-------------- O_cuniculus_ENSOCUP00000009525 GEDLEKSDVSSLIFLMRDYMGRG--------KI--AKDK--------S-FLDLVIELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYK------------QAA-------------- P_troglodytes_ENSPTRP00000048882 GEDLDKSDVSSLIFLMKDYMGRG--------KI--SKEK--------S-FLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYK------------QSV-------------- R_norvegicus_ENSRNOP00000016730 GENLNQSDVSSLIFLTKDYTGRG--------KV--AKDK--------S-FLDLVIELEKLNLIGSDQLNLLEKCLKSIHRIDLKTKIQKYT------------QSS-------------- B_taurus_ENSBTAP00000014607 GEDLDKSDVSSLMFLMRDYTGRS--------KI--AKDK--------S-FLDLVVELEKLNLVAPDQLNLLEESLRNINRIDLKTKIQKYK------------QSA-------------- G_gallus_ENSGALP00000013394 SENLEKDEVSSLVFLLRDFAPRM--------KM--AKDK--------S-FLRLIIELEKLNLVAPNQLDLIENCFRNIHRIDLIKKIEKYK------------QEA-------------- M_musculus_ENSMUSP00000095329 GESLDQNDVSSLVFLTRDYTGRG--------KI--AKDK--------S-FLDLVIELEKLNLIASDQLNLLEKCLKNIHRIDLNTKIQKYT------------QSS-------------- T_guttata_ENSTGUP00000010647 NENLEKDEVGSLGFLLRDYAPRM--------KM--AKDK--------S-FLALIIDLEKLNLVAPNQLDLIENCFQSIHRIDLIRKIQKYK------------HEG-------------- M_domestica_ENSMODP00000036253 SEDMDKSEVTSFVFLLRDYIGGG--------KP--YKNK--------KHFLDVVIELEKVNLISPDKLDLLEKCLKNIHRIDLKKKIQKYK------------QSG-------------- O_anatinus_ENSOANP00000007114 GEDMDKSDVTSFSFLLTDYMGRG--------KK--AVDKKHASSKRPS-LTKPSSPLLPLPFVSPLNLDFLPLLIQNIHRIDLKKKVQKYR------------QAA-------------- A_carolinensis_ENSACAP00000001663 NEDLGKDDLQSLGFLLMNELGAS--------NVKKAKEK--------S-FLTIINDLEKLDLVSPNQLDLIENCFLHIHRKDLAKKIQKFK------------QEG-------------- M_domestica_ENSMODP00000036251 SEEITTEDFEHIKFIMKEHIPKT--------LK--------------T-FLSLLRHMEKQNLLSENNLEILVNICKPLSI-NLIKRIEQYK------------SEK------------GE G_gallus_ENSGALP00000013506 SENITNDMLQEIVFLLRNHLPKR------------RRTI--------S-ALELLILLEKQCLLTENNVQILEEVFRNVSP-DLLETVKCYR------------MAKVALPHQGNTLPIKE X_tropicalis_ENSXETP00000008971 SENIAGDDEKRVYFLLPLQK-----------KH--KENK--------T-FLEVLCQLERENSITEDDVELLEDIFKKVAP-DLLKIIEKYK------------ERGDKLHQTENHLIDPS G_gallus_ENSGALP00000013571 AEDLTPDDVRSIKFLLQEKLPKN--------KL--QDNA--------S-MLKVLVEMERNGIIKEDDLTMLKSILKAFRA-DLKKKIDNYE------------EKT-------------- A_carolinensis_ENSACAP00000001629 SEGFTEENVKTAMFLLREHLPKK--------QS--------------I-AVKLLTSLEKQDLLAEDKLAILEKICNKVSP-ELRNKVDKFK------------ERS-------------- G_aculeatus_ENSGACP00000016969 DQDITRENLSMMKFLLSSQLGKR--------QM--EMCN--------T-ALDVFAEMEKTGSLSPTSLHEVHAAVKQFDQ-QLALTIQRYI------------DNR-------------- R_norvegicus_ENSRNOP00000016613 SEDMDKEDLKSFKFLLITEIPKC--------KL--QDNS--------S-LLDIFVEMEKRTILAENNLVTLKSICFRVNR-SLLGRIDDYE------------RSS-------------- T_nigroviridis_ENSTNIP00000010722 YEDLCKEDLGKIKFFLGDKLGRR--------PT--EMCK--------T-VLDVFAEMEKKGFLSEIYLDELHSVLQNVNP-LLASKVQQHM------------QHL-------------- P_pygmaeus_ENSPPYP00000014602 SEGIDSENLKDMIFLLKDSLPKT--------EM--------------T-SLSFPAFLEKQGKIDEDNLTCLEDL-KTVVP-KLLRNIEKYK------------REK---AVQIVTPPIDK E_caballus_ENSECAP00000004055 SEDVNKLELKSFKFLLSRELPKC--------RL--DDDM--------I-LLDIFIEMEKRVMLGERNLDTLKKICEQVNK-SLLKKINDYE------------ELS-------------- E_caballus_ENSECAP00000021726 SEGMDSDNLNSMMFLLKDSIPKT--------QM--------------T-SLSLLAHLEKQARIDEDNLTLLEMLCKNVVP-NLMRKIEKYK------------REK---AAQVVTAPVDK H_sapiens_ENSP00000286186 SEGIDSENLKDMIFLLKDSLPKT--------EM--------------T-SLSFLAFLEKQGKIDEDNLTCLEDLCKTVVP-KLLRNIEKYK------------REK---AIQIVTPPVDK M_mulatta_ENSMMUP00000037892 SEEVGRSELRSFKFLLQEEISKC--------KL--DDDM--------N-LLDIFVEMEKRVILGEGKLDILKRVCAQVNK-SLLKIINDYE------------EFS-------------- T_guttata_ENSTGUP00000010625 AEDLTSEDVRSVKFLLQKQLPKN--------KL--QENA--------S-MLQVFLEMEIKGIIKEDNMTTLKDILQRFRA-DIKKKIDAYE------------EKK-------------- G_gorilla_ENSGGOP00000010692 GEDLDKSDVSSLIFLMKDYMGRG--------KI--SKEK--------X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------------XXX-------------- P_troglodytes_ENSPTRP00000021879 SEEVSRSELRSFKFLLQEEISKC--------KL--DDDM--------N-LLDIFIEMEKRVILGEGKLDILKRVCAQINR-SLLKIINDYE------------EFS-------------- O_anatinus_ENSOANP00000001054 TGGSNKGIIKXFFFFSSQREKKM--------RS--DAVS--------T-ALGIFIHMEKHGKMNEGDLGMLKKILKDVQP-SLLIPIEEYE------------EKS-------------- H_sapiens_ENSP00000351273 SEEVSRSELRSFKFLLQEEISKC--------KL--DDDM--------N-LLDIFIEMEKRVILGEGKLDILKRVCAQINK-SLLKIINDYE------------EFS-------------- G_aculeatus_ENSGACP00000005791 SEELTADDLKDMKFLLHSYLPRR--------KL--EENV--------S-TLEIWLEMEHKDLMNEHNLHLLEILISKVCP-MLKDKINQLK------------AQQ----------ETPT P_troglodytes_ENSPTRP00000048878 SEGIDSENLKDMIFLLKDSLPKT--------EM--------------T-SLSFLAFLEKQGKIDEDNLTCLEDLCTTVVP-KLLRNIEKYK------------REK---AVQIVTPPVDK O_anatinus_ENSOANP00000006351 SDNVTREELKSITFFLSNDLPRS--------RL--DNKQ--------T-LMGIFIEMEKKGILGESNLDMLKKICDKIDK-TLLGKIDHYE------------ERR-------------- T_rubripes_ENSTRUP00000024467 YENLDREDLKKLKFLLSDQLGRR--------QI--ELCK--------T-VLDVFTEMEKKGLLSNTKLDKLHSVLKEVDQ-RLAATVHDFM------------QPL-------------- B_taurus_ENSBTAP00000038128 SEDVNKVELKDFKFFLSQEIAKC--------KL--DDDM--------T-LLDIFVEMEKRTILGEENLDTLKRICEQVNK-SLLKKIYDYE------------ELR-------------- M_musculus_ENSMUSP00000027189 SEEVSELELRSFKFLLNNEIPKC--------KL--EDDL--------S-LLEIFVEMEKRTMLAENNLETLKSICDQVNK-SLLGKIEDYE------------RSS-------------- C_familiaris_ENSCAFP00000017933 SESIGSENLKDMIFLQRDSMPKT--------QL--------------T-PLSFLAYLEKQALIDEDNLGLLEDLCRKVVP-NLIRKIERYK------------REK---ASEVVTPPVDT T_nigroviridis_ENSTNIP00000001216 SEDLTDDNLKEIKFLLTETLPRR--------KL--EDNV--------T-TLEVFLELECMDLLSKTNLGLLKSILQPVCP-VLAERIRQFE------------AQN-------------- T_guttata_ENSTGUP00000010628 AENITSEMLKEIIFLLRNHLPKG--------WS----------------ALDLLTLLEKQGLLTTDNVKILEDVCMTVSP-DLLETINCYK------------KGK-------------- G_gorilla_ENSGGOP00000000205 SEEVSRSELRSFKFLLQEEISKC--------KL--DDDM--------X-LLDIFIEMEKRVILGEGKLDILKRVCAQINK-SLLKIINDYE------------EFS-------------- C_familiaris_ENSCAFP00000017899 SEDVSKLELKSFKFLLSREISRC--------KL--DDDL--------N-LLDIFIEMEKRVILGERNLDTLKRICDQINK-SLLKKITDYE------------ELN-------------- M_domestica_ENSMODP00000036247 SEGVGPSELKSIKFMLSSKIPKC--------KI--EDDM--------T-LMDLFIEMEKRGILGEGNLDALKIVCDQIDK-SLLKKIQEYE------------ISK-------------- G_gallus_ENSGALP00000013591 SENITKDDMKCFKFLLGKELPKC--------KL--SPET--------T-MPDVFIEMEKKGILKEDNLTVLKTICGKVDK-SLLKKIEDYE----------------------------- T_rubripes_ENSTRUP00000044662 SEELTADDLKDIKFLLNNKLPRG--------KL--EEVT----------TLEVFMELEHRALISDTDLGFLESIIQPVCP-VLLEKINQFN------------AQNCKMHLILHIFDSYL O_latipes_ENSORLP00000014046 HDDMTEENLDKLKFLLNPKLNRR--------PL--EKSK--------T-ALDVFVEMEKSQLISKDDVSGLYKLLLEFDK-KLAAVVEKYM------------QDH-------------- P_pygmaeus_ENSPPYP00000014606 SEEVSRSELRCFKFLLQEEISKC--------KL--DDDM--------N-LLDIFIEMEKRVILGKGKLDILKRVCAQINK-SLLKIINDYE------------EFS-------------- C_intestinalis_ENSCINP00000024485 ADELTEGDLKILKRLCAGKMSKA--------NV--RRSV--------D-VLSWLTCMEEEDLLSEGDLDFIMSILQHLDNQKPYKLFQRVRMNDNTVTLPKNQQKS-------------- G_gallus_ENSGALP00000017288 ----------------------------------------------------MMTDIKDGPRSGEDVSDARSFPGSKG------------------------------------------ D_rerio_ENSDARP00000095527 SEDMTEENFRAAKFLL--DLPRA--------KL--GRST--------S-FLDTLIEMEKQQRLGPDNLDELYRILEKCDK-QLAVMIERFR------------NQS-------------- A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037898 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013731 -------------------------------------MA--------D-DQDCVVEQGAGDSTSTDAVDAKPDRSSFVPS--LFS-KKKKN----------------------------- D_rerio_ENSDARP00000075318 LENLRPDLIKGLSERV---------------------------------INGLLDDLQQKKVFGEEEIEDIQHRMKTRAD-QARHVIDDVK------------RKG-------------- C_familiaris_ENSCAFP00000016420 -------------------------------------MA--------D-DQDCGMEQAAGDSESPDAVDARPDRSSFVPS--LFS-RKKKN----------------------------- D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------S-KKKKN----------------------------- O_anatinus_ENSOANP00000000517 ------------------------------------------------------------AASGEVMVDSKSFHSSQGYS---------------------------------------- M_domestica_ENSMODP00000005556 ------------------------------------------------------------MEDTGTTVDAKSTKNSGV------------------------------------------ T_guttata_ENSTGUP00000006879 -----------------------------------------------------MTDIGDGAHLGKDLADTKSIPGFKG------------------------------------------ P_pygmaeus_ENSPPYP00000003106 PPGRRWHLEKNTSCSGSSGICAS--------YV--TQMA--------D-DQGCVEEQGLGDSANEDSVDAKPDRSSFVPF--LFS-MKKKN----------------------------- P_troglodytes_ENSPTRP00000005216 PPGRKWHLEKNTSCGGSSGICAS--------YV--TQMA--------D-DQGCIEEQGVEDSANEDSVDAKPDRSSFVPS--LFS-KKKKN----------------------------- H_sapiens_ENSP00000358327 PPGRKWHLEKNTSCGGSSGICAS--------YV--TQMA--------D-DQGCIEEQGVEDSANEDSVDAKPDRSSFVPS--LFS-KKKKN----------------------------- B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------S-KKKKN----------------------------- D_rerio_ENSDARP00000076913 SESICDQDLKNIKFLLMKTLSRK--------KL--EQNL--------T-LLQLFLEMEKEDLLGENNLDVLQRIFADIYP-ALGRKINQY------------------------------ O_cuniculus_ENSOCUP00000009498 -------------------------------------MA--------D-DQAHAGELGAGDSESADAVDAKPDRSSFVPA--LFS-KKKKN----------------------------- O_anatinus_ENSOANP00000002508 ------------------------------------------------MADDQAPTMHQKECDFEDEVDAKPERLKVAQL-----FSKKKN----------------------------- O_latipes_ENSORLP00000010095 ---------------------------------------------------------MASNRPGEDSTDARKDNGELAAG---------------------------------------- R_norvegicus_ENSRNOP00000022693 -------------------------------------MT--------D-DQDCAAELEMADSSTEDGVDAKPDRSTIISS--LLW-KKKKN----------------------------- A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 -------------------------------------MT--------D-DQDCAAELEKVDSSSEDGVDAKPDRSSIISS--ILL-KKKRN----------------------------- D_rerio_ENSDARP00000075645 SNPNNSNQINRASPNEQEKIKTD--------------------------------EPKRKNTSQEDKENLHKGVQNNNSPKRQREPLQ-------------------------------- X_tropicalis_ENSXETP00000035938 -------------------------------------------------------------------------------------STKKKK----------------------------- D_rerio_ENSDARP00000071815 --------------------------------------------------------MSDVKPKGVDTVDARQSDAKESSS---------------------------------------- B_taurus_ENSBTAP00000016642 -------------------------------------MS--------S-EPPPRRARGPGEEQNMTEIDAFP------------------------------------------------ B_taurus_ENSBTAP00000021099 ------------------------------------------------------------MENTENSVDSKSIKTSET------------------------------------------ G_gorilla_ENSGGOP00000007184 -------------------------------------MA--------D-DQGCVXXXXXXXXXXXXXXXXXXXXXXXXXX--XXX-XXXXX----------------------------- B_taurus_ENSBTAP00000004858 SEGISSENLQSMIFLLNESIPNV--------QM--------------T-SRSFLMCLEKQAKIDEDNVTLLENLCQKIVP-NLMEKLHKYK------------RER-------------- G_gallus_ENSGALP00000014503 ---------------------------------------------------------------------------------------KKKN----------------------------- T_guttata_ENSTGUP00000011206 ---------------------------------------------------------------------------------------KKKN----------------------------- P_troglodytes_ENSPTRP00000028104 -------------------------------------MS--------S-ASGLRRGHPAGGEENMTETDAFY------------------------------------------------ G_aculeatus_ENSGACP00000008661 -------------------------------QVNGARLT--------S-AQDVA---AEEGGPTGDQTDAKPDRRGRFLL--FGNIKKNKD----------------------------- C_intestinalis_ENSCINP00000011503 ------------MERMSDETPRK--------PA--AGDV--------L-KIYKSEVKRNATSESDENIDAISDSSDDF------------------------------------------ D_rerio_ENSDARP00000019984 LTSENEVSGDDQENYGKGDVTDAKPDPKAMCRVDKEALT--------S-EIEVLEEDQDSYGE-EDVTDAKPDRKGRFRL--FGNF--KKN----------------------------- H_sapiens_ENSP00000265164 -------------------------------------MS--------S-ASGLRRGHPAGGEENMTETDAFY------------------------------------------------ P_pygmaeus_ENSPPYP00000016744 -------------------------------------MS--------S-VSGLRRGHPAGGEENMTETDAFY------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------MENTENSVDSKSIKNLEP------------------------------------------ P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------MENTENSVDSKSIKNLEP------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029626 ----------------------------------------------------------------MTETDGFY------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------------------------------MEDTGTTVDAKSIKNSGV------------------------------------------ T_rubripes_ENSTRUP00000031759 ---------------------SM--------QM--AGEP--------T-EISDLGGEVEEGGQSEDDVDAKPDRKGRFLL--FKS-KKNKD----------------------------- O_cuniculus_ENSOCUP00000006164 XXXXXXXXXXXXXXXXXXXXXXX--------XX--XXXX--------X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX----------------------------- O_latipes_ENSORLP00000015114 VQKTSHHRSFKLLLLLPKRGPRAFKSFCSALKE--TEQE--------H-LCDLLTQEEEGREVCLDTPLINSEEQSEVSS-SMSYPIHDSE--------GLQLEMR-------------- C_intestinalis_ENSCINP00000011493 STSYSGGDILSMA---SPPLPVT--------RI--TERT--------Q-TAGEVIRTYNPSPEKRDHEVSYDELLEEDMK-FSAEGVSDSVKHFYGAAIPVTCDDR-------------- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000072840 ---------------------QNMPCAAPNTFKFTPMQCQPFEKQVRQSQC-----------FNHEFNKLKLSVPETGIHYQQ------------------AITEEYQMNPEQRGLCVII T_rubripes_ENSTRUP00000032169 ---------RELMDSMCNVSFTPSAATLEQNSQQQRSRTPQYINPSIISYFTRPSGHFLHHFALHQSQKTYQSLHPE------------------------NQLESYRFTSNPRGGCLII O_latipes_ENSORLP00000020363 -----------------FRQNQKKSIISAERQAFIRKLTSECGRDVVLSQTSARMENKDLLLIHNDLNKEILSNSTFFNGAFQLQH---------------SQLEQYSLNSKPRGLCVII G_aculeatus_ENSGACP00000008246 ---------------EGTETNYKSCLHNTWSRLYSDDHNTQYTVKVPQVNTQMDLTSEH---IHHFRTKLYIHQTKCCSFALQ------------------SQMEFYKCNTNPRGVCVII T_nigroviridis_ENSTNIP00000019557 ----------------------KTQSSCKHRQIMYAAYESDAKNPSILSHFKAP-GHSLYHFALHQSQKPFQFLHSEVRVPRQ------------------NPLDSYRMTSNPRGVCLII C_familiaris_ENSCAFP00000017879 ---------QG----AGTNYTNALQASFPNLSLKDPSCNLRLQNGRSKEQRLSVRQ------LDLQRESVKASVQESGP------------FLPR-----HIPEERYRMQSKPLGICLII M_mulatta_ENSMMUP00000037902 ---------QG----AGAGYKNVLQAAIQK-SLKDPSNNFRLHNGRSKEQRL-KEQ------LGTQQEPVKTSIQESEA------------FLPQ-----SIPEERYKMKSKPLGICLII E_caballus_ENSECAP00000018899 ---------PG----TGTSYVNALQASLPNLSLKDPSYNLRLQNGRSKEQRLIVEQ------LDTQK-PVKTSVQESGA------------FLPQ-----HIPEQRYKMQSKPLGICLII P_pygmaeus_ENSPPYP00000014600 ---------QG----AGTSYRNVLQAAIQK-SFKDPSNNFRLHNGRSKEQRL-KEQ------LGTQQEPVKKSIQESEA------------FLPQ-----SVPEERYKMKSKPLGICLII H_sapiens_ENSP00000312455 ---------QG----AGTSYRNVLQAAIQK-SLKDPSNNFRLHNGRSKEQRL-KEQ------LGAQQEPVKKSIQESEA------------FLPQ-----SIPEERYKMKSKPLGICLII O_cuniculus_ENSOCUP00000009525 ---------QG----VERNYTNGFQASLPNLNLKDFSYNL-LXXXXXXXXXX-XXX------XXXXXXAVKTSIQESAA------------FMPQ-----HPPEERYRMQSKPLGICLII P_troglodytes_ENSPTRP00000048882 ---------QG----AGTSYRNVLQAAIQK-SLKDPSNNFRLHNGRSKEQRL-KEQ------LGTQQEPVKKSIQESEA------------FLPQ-----SIPEERYKMKSKPLGICLII R_norvegicus_ENSRNOP00000016730 ---------QE----ARSN-MNALQASLPKLSIKEHLYNSRLQNGRSKEPRF-VEH------HGIQRKPVKTSIQESGI------------FLPP-----HIHEESYRMQSKPLGICLII B_taurus_ENSBTAP00000014607 ---------QG----AETNYVNARQASLPNLSVKDPSYNLRLQNGRSKEQRLMMGP------PDIQREPVKRPIQESGA------------FLPQ-----HIVEERYKMQSKPLGICLII G_gallus_ENSGALP00000013394 ---------FISSVHSQPVYVNALQASLPNLSLIDPPYNSGFQNMNKEKSQ--NGE------IFFQEEPVHVSIQESGPASHKF-------------------PQVYRMQSQPLGVCLII M_musculus_ENSMUSP00000095329 ---------QG----ARSN-MNTLQASLPKLSIKPSVLYLKLQNGRSKEPRF-VEY------RDSQRTLVKTSIQESGA------------FLPP-----HIREETYRMQSKPLGICLII T_guttata_ENSTGUP00000010647 ---------EMLFLYWLLLIATIRCAE----------NKTGICILCRSR--------------FSKQLKYHDTLQPSRQISASYLMENNRMLFNT-----SMSDDSYRMQSQPLGICLII M_domestica_ENSMODP00000036253 ---------KNNFDLSSSSIIQSKEMLINRSNFYDLVLSFKLKNGIKKEERPTFGQ------RGISTEPLKLSIQESRK------------SLPQ------MADDIYRLRSQPLGVCLII O_anatinus_ENSOANP00000007114 ---------LGASN-FQPNYVNAVQASLPNLSLLEP---LSCQENNSKEKSILADK------PMFPAEPVKTSVQELGL------------AVIQ-----PPPDERYRMQSQPLGICLII A_carolinensis_ENSACAP00000001663 --------------KIIVSQPLALQGFGPKAG---SHWSSNLQPGNIWRTRSTN--------YRELTKWLYYSTQCSHLA-----------SLPQ------ISEQKYKMQSQPLGVCLII M_domestica_ENSMODP00000036251 LPEFELIPYHGCGVISEQVSLMTFLSLLPLFSWSRKHLPFSQQNEANNSLEEVT-----------------GLWAQGAEGGTLFSDMT-------------NEAKFYRMDHSHRGHCIIF G_gallus_ENSGALP00000013506 SSPS-YTVHVRLFNSPQGGSFILVLNESYCESLRNKKYSVTGASAACHAISMPS-----------------TGVQNALANTTVCYSSF-------------LQVSSYKMDGPRRGICLVI X_tropicalis_ENSXETP00000008971 APPEDEHELINPPLSIQVSSKDSELWDKGTESLIEHTGMIHEEAEKEDDKSGNI-----------------NHQLSDLRLNSEMTPQA-------------NKEEFYDMNHKHRGYCLII G_gallus_ENSGALP00000013571 ---------------KGWPWKSSCFPNKTQALSISENLAVSSLIDNKESQE--------------------SQSEWYSAGIFPPHVQI-------------LLVESYKMENNPHGYCVIL A_carolinensis_ENSACAP00000001629 ----------------VFKAFVFSLCYENLYPSNFLAVFLLIL----------------------------------------------------------QASTCYKMDGLNRGSCLIF G_aculeatus_ENSGACP00000016969 ----------------------GTATPRPHRPIHPQPVDVSISETQSNCSSDEG-----------------MNICSDAEPNTKPSSPD-------------DHTEYYALIHKPRGLCVVI R_norvegicus_ENSRNOP00000016613 --------------------TERRMSTEG-----GEELPVSVLDEVTI-----------------------KMQDMWDSPGEQESESL-------------NSDNVYQMKSKPRGYCLIF T_nigroviridis_ENSTNIP00000010722 ---------------------RDNHRPVAALPSDPAQVRLPVRETQLRDVE--------------------QNLFSDAEPAVRPSRTA-------------NDTEYYSLTHKPHGLCVVF P_pygmaeus_ENSPPYP00000014602 EAES-YQGEEELVSQTDVKTFLEALPQEESW-QNKHAGSNGNRATNGAPSLVS------------------RGMQGASANTLNSETGT-------------KGRKGYRMNRNHRGLC-LL E_caballus_ENSECAP00000004055 --------------------REGRISLERSPDEFSNASLKCLQREGSL-----------------------AGQAMSDSPGQQNSESQ-------------TSDKVYRMESKPRGYCLIF E_caballus_ENSECAP00000021726 ETESLHHGEEELFSRSDIKKFSRALPQ-----PWEHTHAGLGSLPLGN-SRVS------------------KGWSSALASGIGSISSS-------------KETPLYRMDRTHRGHCVVV H_sapiens_ENSP00000286186 EAES-YQGEEELVSQTDVKTFLEALPQ-ESW-QNKHAGSNGNRATNGAPSLVS------------------RGMQGASANTLNSETST-------------KRAAVYRMNRNHRGLCVIV M_mulatta_ENSMMUP00000037892 --------------------RERTRSLEGSPEEGSNG-------EELC-----------------------GLMTISDSPREQDSESQ-------------TLDKVYQMKSKPRGYCLII T_guttata_ENSTGUP00000010625 --------------------KGLTGSAEVSL-----ELPVSWIDSVDH-----------------------IKQSTLGLPGEDRSLSF-------------QLLEAYKMTSRPCGVCLIL G_gorilla_ENSGGOP00000010692 ---------XX----XXXXXXXXXXXXXXX-XXXXXXXXXXLHNGRSKEQRL-KEQ------LGTQQEPVKKSIQESEA------------FLPQ-----SIPEERYKMKSKPLGICLII P_troglodytes_ENSPTRP00000021879 --------------------KERSSSLEGSPDEFSNG-------EELC-----------------------GVMTISDSPREQDSESQ-------------TLDKVYQMKSKPRGYCLII O_anatinus_ENSOANP00000001054 --------------------RGFCVSQSRSSWKLKHCLGTTLPHHSYRNY---------------------NQQVSSPKAAEEMERIS-------------QIMAPYKMNHLPHGFCVII H_sapiens_ENSP00000351273 --------------------KERSSSLEGSPDEFSNG-------EELC-----------------------GVMTISDSPREQDSESQ-------------TLDKVYQMKSKPRGYCLII G_aculeatus_ENSGACP00000005791 SPATQESGRQGSLSAPNAPNQVPQSLGAEGTGLFEMQDSPSGFNGGGDCAALSLGLSGHLKIEVVETMPPPKNMSCSEPPTSQPSDTNT------------EVLGTYPMTSAKRGICLIV P_troglodytes_ENSPTRP00000048878 EAES-YQGEEELVSQTDVKTFLEALPQ-ESW-QNKHAGSNGNRATNGAPSLVS------------------RGMQGASANTLNSETST-------------KRATVYRMNRNHRGLCVIV O_anatinus_ENSOANP00000006351 --------------------ADCTLHSSEHLTVLDRDMYIIPIIYDEII----------------------LLPTESSFRGHSGGEAE-------------QNGDFYKMNSNPRGYCLII T_rubripes_ENSTRUP00000024467 ---------------RGILVPRGPGTPPPAVMSMVIPVRLAVPETQSRGTE--------------------QNVSPDAESIFQSSPPA-------------DDNEYYALIHNPRGLCVVF B_taurus_ENSBTAP00000038128 --------------------KERRMSLERDPYAFSNDMSQSLPEEGYS-----------------------KMPAMSDSP-EQDSELQ-------------TSDTVYRMTSKPRGYCLIF M_musculus_ENSMUSP00000027189 --------------------TERRMSLEG-----REELPPSVLDEMSL-----------------------KMAELCDSPREQDSESR-------------TSDKVYQMKNKPRGYCLII C_familiaris_ENSCAFP00000017933 ETESLHQKEEELFSPSDINQFHGALSKQTSWNPLKHRAKQGNIISDGA-TLVS------------------VEMLEASTGPLTSETST-------------KEANVYRMDRKHRGHCVIV T_nigroviridis_ENSTNIP00000001216 --SCQPAADWGFAVKKITDPLQVQGGSDALPSLPEENQSSSRTEASVMSSANAVGIKPGT-----------LMLGLSPPPVGSPNFPV-------------QDLGTYPMTTLPRGCCLII T_guttata_ENSTGUP00000010628 -----------------GEKFIISLHGDFIKSFP------------------------------------------------------------------------------------LA G_gorilla_ENSGGOP00000000205 --------------------KERSSSLEGSPDEFSNG-------EELC-----------------------GVMTISDSPREQDSESQ-------------TLDKVYQMKSKPRGYCLII C_familiaris_ENSCAFP00000017899 --------------------REQTMNLQRSLDEISNDMSQLPIREGSV-----------------------KILPMSDSLGEQDYESE-------------TSDKVYRMKSKPRGYCLIF M_domestica_ENSMODP00000036247 --------------------GRNNL----------------------------------------------FLIYQNTQPQEVYDSAG-------------EKGNVYKMSSRPRGYCLII G_gallus_ENSGALP00000013591 ----------------------LNLLGEGEMLVTEGQRSSTGAPEDSAI----------------------WLASSVAPDSLGNCDQS-------------SQLEVYKMTSRPRGVCLIL T_rubripes_ENSTRUP00000044662 NQIQLNTQLKALWLIKKFDSFLVSFSSNESWIGGSGNRPTNRCPLLTAASLLE------------------QSCSFNTLQVGCPDVSV-------------QGVETYLMTAAKRGRCLII O_latipes_ENSORLP00000014046 ---------------RGALTDTSHYQKRPSIPSLE-SLSVSQPETWSETEDPN------------------NGVRSDATPCPDPPTSP-------------DEEEYYSFTHEPRGLCVIF P_pygmaeus_ENSPPYP00000014606 --------------------R---------------G-------EELC-----------------------GVMTISDSPREQDSESQ-------------TLDKVYQMKSKPRGYCLII C_intestinalis_ENSCINP00000024485 ----------------------NAFQPNSHLPVASGFNSLSKQEYNHTSKLEPQYVSMENHRAFNGGYNQYNNYQSEIKDTSTM-----------------GILDKYPM--ERRGYCLII G_gallus_ENSGALP00000017288 ---------------------------------------------------------------------------MNLPASKSVDSGI-------------LPDDSYRMDYPEIGVCVII D_rerio_ENSDARP00000095527 ---------------------HRDQEQGGRLPLEEVFLNNPVSETMERER---------------------RRNSSAGTITTDAETPL-------------NKKKFYISSTAPLGICFLR A_carolinensis_ENSACAP00000002670 -----------------------------------------------------------------------------IPVSKSVDSVI-------------EADESYRMDHPEMGLCILV M_mulatta_ENSMMUP00000037898 -----------------------------------------------------------------------------------------------------KRAPTYRMDRNHRGLCVIV E_caballus_ENSECAP00000013731 -----------------------------------------------------------------------GPE-----RSITTNRNR-------------EPTYQYNMNFEKVGKCVII D_rerio_ENSDARP00000075318 -----------VKASEIMLASLKTRDPHLYDTLGIERLLVPVPETE-------------------------LTPSQLSETTGCSTDKT-------------NTMNEYEMKSNPRGLCLIF C_familiaris_ENSCAFP00000016420 -----------------------------------------------------------------------DSG-----RSIKTAQDQ-------------VPTYQYNMNFEKVGKCIII D_rerio_ENSDARP00000024255 --------------------------------------------------------------------------------------------------------EQYEMKGERRGVCLII M_mulatta_ENSMMUP00000001627 -----------------------------------------------------------------------VSG-----QSIKTTRDR-------------VPTYQYNMNFEKMGKCIII O_anatinus_ENSOANP00000000517 --------------------------------------------------------------------------SRKVPGKQFLGSSA-------------SLDDRYRMDYPNMGICLII M_domestica_ENSMODP00000005556 ---------------------------------------------------------------------------KLFHGSKSVESGL-------------S-SDSYKMDYPEMGLCIII T_guttata_ENSTGUP00000006879 ---------------------------------------------------------------------------KNLPASKSMDSGI-------------LPDYSYRMDYPEMGECIII P_pygmaeus_ENSPPYP00000003106 -----------------------------------------------------------------------VSM-----QSIKTTRDR-------------VPTYQYNMNFEKLGKCIII P_troglodytes_ENSPTRP00000005216 -----------------------------------------------------------------------VTM-----RSIKTTRDR-------------VPTYQYNMNFEKLGKCIII H_sapiens_ENSP00000358327 -----------------------------------------------------------------------VTM-----RSIKTTRDR-------------VPTYQYNMNFEKLGKCIII B_taurus_ENSBTAP00000008706 -----------------------------------------------------------------------DSG-----KSVNIPRDR-------------VPTYQYNMNFEKVGKCIII D_rerio_ENSDARP00000076913 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000009498 -----------------------------------------------------------------------GPK-----QSAKATRDQ-------------VPSYQYNMNFDKMGKCIII O_anatinus_ENSOANP00000002508 -----------------------------------------------------------------------EAESQSGGPLPVRNRVV-------------SSSFIYNMKYENLGKCIII O_latipes_ENSORLP00000010095 -------------------------------------------------------------------------ASPAPDRMDVDGKPS-------------SHSFRYSLNFPTIGLCIII R_norvegicus_ENSRNOP00000022693 -----------------------------------------------------------------------ASM-----CPVSTTRDR-------------VPTYLYRMDFEKMGKCIII A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------PTFRYRMDYKKLGKCVII M_musculus_ENSMUSP00000026062 -----------------------------------------------------------------------ASA-----GPVRTGRDR-------------VPTYLYRMDFQKMGKCIII D_rerio_ENSDARP00000075645 -----------------------------------------------------------------------STCNISDHYPKRKRAVT-------------EQKEWYSMSNRPLGYCLII X_tropicalis_ENSXETP00000035938 -----------------------------------------------------------------------TEDPEKPPQASDNVRIV-------------TPAFQYKMNYGKVGRCIII D_rerio_ENSDARP00000071815 -----------------------------------------------------------------------VTDPGLVQMDAKSHSDD-------------NVDYQYKTNYPNLGQCLII B_taurus_ENSBTAP00000016642 ----------------------------------------------------------------------------------R-REIF-------------DPTEKYKMDHKRRGIALIF B_taurus_ENSBTAP00000021099 ---------------------------------------------------------------------------KILHGSKSMDSGI-------------SLEESYKMDYPEMGLCIII G_gorilla_ENSGGOP00000007184 -----------------------------------------------------------------------XXX-----XXXXXXXXX-------------XXXXXXXXXXXXXXXXXXX B_taurus_ENSBTAP00000004858 -------------