>D_rerio_ENSDARP00000071815 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MSDVKPKGVDTVDARQS-----------DAKESSSVT-DPGLVQMDAKSH SDDNVDYQYKTNYPNLGQCLIINNKNFH-------KRTGMGVRNGTDEDAKK-VFETFSQ LGFK-VGHYNDLTVSQMMALLNKASQE-DHS--KSAMFACVLLSH--GDD-------GL- IYGTDN-SIELKRLFA---HFRGDRCTSLVGKPKLFFIQ--ACR----GTDLDSGIEC-- ----DGVG----------------------------DEE-TQRIPVEADFLYAYSTAP-- GYYAWRNVANGSWFISSLCDMLLKYG-------KQLEIMQVMTRVNHKVALE---FESSS NL-PGFDGKKQIPCIVS-----MLTKELYF-PK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------TNMSANGPSPGGDFTDAKKGAG---------QQPRSGSSS---GRVTVDA--- KPAAYSFRYSLDFPNMGHCIIINNKNFD-------RRTGMNTRNGTDVDAAN-AMKVFLS LGYK-VKVHNDQTVNQMKQLLVSAAEE-DHS--ACASFVCVLLSH--GDE-------GV- FFGTDG-SVELKYLTS---LFRGDRCKSLVGKPKLFFIQ--ACR----GNDLDGGIET-- ----DSAA----------------------------DSS-TTKIPVEADFLYAFSTAP-- GYYSWRNTTSGSWFMQSLCDAISKYG-------KELELQHILTRVNHKVAVD---FESVS NL-PGFDAKKQIPCIVS-----MLTKEMYFS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_rerio_ENSDARP00000006831 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MNGDCVDAKRVDTTD-------ASKDGASAS---QPMQVDA--- KPQSHAFRYSLNYPNIGHCIIINNKNFD-------RRTGMNPRNGTDVDAGN-VMNVFRK LGYI-VKVYNDQTVAQIMQVLTTVAHD-DHS--RCASLVCVLLSH--GDE-------GV- FFGTDT-SVDLKSLTS---LFRGDRCPSLVGKPKLFFIQ--ACR----GTELDPGVET-- ----DHPDH------------------------PDIPDG-RVRIPVEADFLYAYSTVP-- GYYSWRNTMTGSWFIQSLCEMMTKYG-------SELELLQIMTRVNHKVALD---FESTS NM-PGFDAKKQIPCIVS-----MLTKEMYFTP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MSANGPASGEDFTDASKGG----------EQPSGSSSS---GKMTVDA--- KSARYSFRYSLDFPNLGHCIIINNKNFD-------RRTGMNTRNGTDVDAAN-AMKVFSN LGYR-VRVHNDQTVAQISQLLTSAAKE-DHS--RCASFVCILLSH--GDE-------GV- LYGTDG-PMEIKSLTS---LFRGDRCRSLVGKPKLFFIQ--ACR----GNDLDGGIET-- ----DSIE----------------------------DNS-TTKIPVEADFLYAFSTAP-- GYYSWRNTMSGSWFMQSLCDTISKYG-------KELELQHILTRVNHKVAVE---FESDS SL-PGFNAKKQIPCIVS-----MLTKEMYFS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_latipes_ENSORLP00000010095 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MASNRPGEDSTDARKD-----------NGELAAGASPAPDRMDVDG--- KPSSHSFRYSLNFPTIGLCIIINNKNFD-------RGTGMNQRNGTDIDAAS-AMKVFSK LGYR-VKIYNDQTVKQIKQLLTDVSRM-DHS--DSASFVCILLSH--GDE-------GV- FFGTDG-SIELKTLTS---LFRGDHCKSLVGKPKLFFIQ--ACR----GTELDDGIEA-- ----DSKE------------------------------D-TTKIPVEADFLYAFSTAP-- GYYSWRNTMTGSWFINSLCEMLSKYG-------KELELLHIMTRVNHMVAVE---FESIS TL-PGFHAKKQIPCIVS-----MLTKEMYFYP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MSVNGPGEDRTDAKTE-----------QSEVSSSAS---APEEVDA--- KPNVHSFRYSLSFPSIGQCIIINNKNFD-------RGTGMNQRNGTDVDAAN-AMKVFGN LGYK-VKVYNDQSVAQIQHVLTSVSKQ-DHS--CSASFVCVLLSH--GDG-------DL- FFGTDG-PVPLKSLTS---LYRGDRCKSLVGKPKLFFIQ--ACR----GTELDPGIEA-- ----DSVK-----------------------------DE-TTRIPVEADFLYAFSTAP-- GYYSWRNTTTGSWFMQSLCDMISKYG-------KELELQHIMVRVNHKVAVA---FESVS NS-PDFNARKQIPCVVS-----MLTKEMYFSP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------MEESHNGVQYGEDTADAKTY-----------FTNQQISLQNCDIKDMEKK--- TKFAHLHKYRTDYPEMGICLIINNKNFQ-------SSTNMGVRNGTDVDARK-LHETFTG LGYK-VKVCNDQKSNDIFTLLKKMSEE-DHS--KRSSFVCAILSH--GED-------GL- VYGVDG-PIQIKNLTD---LFRGDRCKTLVGKPKLFFIQ--ACR----GTDLDSGIET-- ----DSGS--------------------------EPGEE-IQRIPVEADFLYAYSTVP-- GYYSWRNTMNGSWFIQSLCEMIKLYG-------PHLELIQILTCVNHMVALE---FESCS TQ-QAFHAKKQIPCVVS-----MLTKAFYFLK---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_guttata_ENSTGUP00000006879 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------MTDIGDGAHLGKDLADTKSI-----------PGFK---GKNLPASKSMD---- SGILPDYSYRMDYPEMGECIIINNKNFH-------RYTGMSPRSGTDADAAS-VREVFMK LGYK-IKINNDLSCEGIFNLLKNVSEE-DHS--KRSSFVCVLLSH--GDE-------GL- IYGTDG-PLELKALTS---LFRGDRCRSLAGKPKFFFIQ--ACR----GTELDSGIET-- ----DSGS---------------------------EETM-CQKIPVEADFLYAYSTAP-- GYYSWRNSAEGSWFIQSLCKMLKEHA-------RKLELMQILTRVNRRVA-E---YESCS TR-QDFNAKKQIPCIVS-----MLTKEFYFPS---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_latipes_ENSORLP00000010793 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MDMAETAEELSGKDQVDTKPV-----------ISKRSPANQ--PNPRSTDVCVI KQDADPYRYSMDYPKMGICLIINNKNFH-------KDSGMGPRNGTDNDAAA-AWKSFMK LGYE-IQMYNDQTVDQMKKLFRQMSNQ-DHS--KFASFACVILSH--GEE-------GV- IYGTDG-PVSFNKLIE---CLKGRSCLSLVGKPKLFFIQ--ACR----GTLFDEGIEH-- ----DAKD-----------------------------DT-SEKIPLEADFLFAYSTVS-- GYYSWRSTANGSWFIQSLCEMLEKFS-------KTLDLMQIMTRVNHKVATH---FESSS NA-PGFSGKKQIPCIVS-----MLTKDFYF-PYESN------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------IPVSKSVD---- SVIEADESYRMDHPEMGLCILVNNKNFH-------PATGMSYRSGTDRDAAH-VVDTFRT LGYM-VKPYNDLTCKQIVDVLHNVSKD-DHH--KRNSFVCVLLSH--GED-------GL- IYGTDG-HVELKMLTS---FFRGDKCKSLAGKPKLFFIQ--ACR----GTELDSGIET-- ----DSAS---------------------------DESM-CQKIPVEADYLYAYSTAP-- GYYSWRNSSDGSWFIQSLCSMLKQYS-------HKLELMQILTRVNRKVT-E---FTSCS NH-PDFHGKKQIPCIMS-----MLTKDFYFPH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_gallus_ENSGALP00000017288 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MMTDIKDGPRSGEDVSDARSF-----------PGSK---GMNLPASKSVD---- SGILPDDSYRMDYPEIGVCVIINNKNFH-------RDTGLSSRSGTDADAAS-VREVFMK LGYK-VKLNNDLSSRDIFKLLKNVSEE-DHS--KRSSFVCVLLSH--GDE-------GL- FYGTDG-PLELKVLTS---LFRGDKCRSLAGKPKLFFIQ--ACR----GTELDSGIEA-- ----DSGP---------------------------DETV-CQKIPVEADFLYAYSTAP-- GYYSWRNAAEGSWFIQSLCRMLKEHA-------RKLELMQILTRVNRRVA-E---YESCS TR-QDFNAKKQIPCIVS-----MLTKEFYFPC---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MADDQAHAGELGAGDSESADAVDAKPDRSSFV------PALFSKKKKNGPKQSAKAT--- RDQVPSYQYNMNFDKMGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFRS LGFD-VMVYNDCSCARMQDLLKRASEE-DHT--NSACFACILLSH--GEE-------NL- IYGKDG-VIPIKDLTA---HFRGDRCKTLLEKPKLFFIQ--ACR----GTELDDGIQA-- ----DSGPIN-----------------------DTDANP-RHKIPVEADFLFAYSTVP-- GYYSWKNPGRGSWFVQALCSILDEHG-------KELEVMQILTRVNDRVARH---FESQS DD-PRFNEKKQIPCVVS-----MLTKELYFCR---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MDCVGWPPGRRWHLEKNTSCSGSSGICASYVTQ MADDQGCVEEQGLGDSANEDSVDAKPDRSSFV------PFLFSMKKKNVSMQSIKTT--- RDRVPTYQYNMNFEKLGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFRS LGFD-VIVYNDCSCAKMQDLLKKASEE-DHT--NAACFACILLSH--GEE-------NL- IYGKDG-VTPIKDLTA---HFRGDRCKTLLEKPKLFFIQ--ACR----GTELDDGIQA-- ----DSGPIN-----------------------DTDANP-RYKIPVEADFLFAYSTVP-- GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIMQILTRVNDRVARH---FESQS DD-PRFHEKKQIPCVVS-----MLTKELYFSQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >B_taurus_ENSBTAP00000008706 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SKKKKNDSGKSVNIP--- RDRVPTYQYNMNFEKVGKCIIINNKNFD-------RITGMGVRNGTDKDAEA-LFKCFRS LGFD-VSVYNDCSCAKMQDLLKKASEE-DHR--NSACFACILLSH--GEE-------NL- IYGTDG-KTAIKDLTA---HFRGDRCKTLLEKPKLFFIQ--ACR----GTELDDGIQA-- ----DSGPIN-----------------------DTDANP-RYKIPVEADFLFAYSTVP-- GYYSWRNPGSGSWFVQALCSILNEHG-------KSLEILQILTRVNDRVARH---FESQS DD-PRFHEKKQIPCVVS-----MLTKELYF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >H_sapiens_ENSP00000358327 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQ MADDQGCIEEQGVEDSANEDSVDAKPDRSSFV------PSLFSKKKKNVTMRSIKTT--- RDRVPTYQYNMNFEKLGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFRS LGFD-VIVYNDCSCAKMQDLLKKASEE-DHT--NAACFACILLSH--GEE-------NV- IYGKDG-VTPIKDLTA---HFRGDRCKTLLEKPKLFFIQ--ACR----GTELDDGIQA-- ----DSGPIN-----------------------DTDANP-RYKIPVEADFLFAYSTVP-- GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIMQILTRVNDRVARH---FESQS DD-PHFHEKKQIPCVVS-----MLTKELYFSQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQ MADDQGCIEEQGVEDSANEDSVDAKPDRSSFV------PSLFSKKKKNVTMRSIKTT--- RDRVPTYQYNMNFEKLGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFRS LGFD-VIVYNDCSCAKMQDLLKKASEE-DHT--NAACFACILLSH--GEE-------NV- IYGKDG-VTPIKDLTA---HFRGDRCKTLLEKPKLFFIQ--ACR----GTELDDGIQA-- ----DSGPIN-----------------------DTDANP-RYKIPVEADFLFAYSTVP-- GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIMQILTRVNDRVARH---FESQS DD-PRFHEKKQIPCVVS-----MLTKELYFSQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >E_caballus_ENSECAP00000019797 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENSKISVDSKSI-----------KNSE---TKILHGSKSMD---- SGISLDSSYKMDYPEMGLCIIINNKNFH-------KSTGMASRSGTDVDAAN-LRETFTN LKYE-VRNKNDLTGEEIVALMRSVSKE-DHS--KRSSFICVLLSH--GEE-------GI- IFGTNG-PIDLKKLTC---FFKGDCCRSLAGKPKLFIIQ--ACR----GTELDSGIET-- ----DSGI--------------------------EDDMA-CQKIPVEADFLYAYSTAP-- GYYSWRNSKDGSWFIQSLCAMLKLYA-------HKLELMHILTRVNRKVAME---FESYC LD-PTFHGKKQIPCIVS-----MLTKELYFYH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >E_caballus_ENSECAP00000013731 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MADDQDCVVEQGAGDSTSTDAVDAKPDRSSFV------PSLFSKKKKNGPERSITTN--- RNREPTYQYNMNFEKVGKCVIINNKNFD-------RGTGMGVRNGTDKDAEA-LFKCFRN LGFD-VVVYNDCSCAKMKSLLKQASEE-DHR--NSACFACILLSH--GEE-------NL- IYGTDG-MTPIKDLTG---HFRGDRCKTLLEKPKLFFIQ--ACR----GTELDDGIQA-- ----DSGPIND----------------------DTDANP-RYKVPVEADFLFAYSTVP-- GYYSWRNPGSGSWFVQALCSILNEHG-------KSLEIIQILTRVNHRVARH---FESHS DD-PRFHQKKQIPCVVS-----MLTKELYF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_musculus_ENSMUSP00000091238 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENNKTSVDSKSI-----------NNFE---VKTIHGSKSVD---- SGIYLDSSYKMDYPEMGICIIINNKNFH-------KSTGMSSRSGTDVDAAN-LRETFMG LKYQ-VRNKNDLTREDILELMDSVSKE-DHS--KRSSFVCVILSH--GDE-------GV- IYGTNG-PVELKKLTS---FFRGDYCRSLTGKPKLFIIQ--ACR----GTELDCGIET-- ----DSGT--------------------------DEEMA-CQKIPVEADFLYAYSTAP-- GYYSWRNSKDGSWFIQSLCSMLKLYA-------HKLEFMHILTRVNRKVATE---FESFS LD-STFHAKKQIPCIVS-----MLTKELYFYH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_anatinus_ENSOANP00000000517 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------AASGEVMVDSKSF-----------HSSQGYSSRKVPGKQFLG---- SSASLDDRYRMDYPNMGICLIINNKNFH-------PDTRMGCRSGTDVDAAS-LRDTFKK LKYE-VRCKNDLKRREILELLTSVAHE-DHS--KRSSFVCVLLSH--GEE-------GV- IFGTDG-SLELKSLAS---LFRGDNCRSLVGKPKLFIVQ--ACR----GTELDSGVEA-- ----DSSS--------------------------ADDGS-EQKIPVEADFLYAYSTAP-- GYYSWRNSMNGSWFIQALCAMLKQHA-------HTLELLHILTRVNRKVATE---FESYS LD-ATFNAKKQIPCIVS-----MLTKELYFPY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MGEQRNTSSKELAA AEATGQSGKELEVSMENTENSVDAKSF-----------KNAE---TVIV---KILK---- DKYLTKLHYKMDYPEMGLCIIINNKNFH-------KSTGMAPRSGTDVDAAN-LRETFTN LKYE-VRNKNDLTCEEILELMNSVSKE-DHS--KRSSFVCVLLSH--GDE-------GI- IFGTNG-PVDLRKVTG---FFRGDYCRSLTGKPKLFIIQ--ACR----GTELDCGIET-- ----DSGI--------------------------EDDMA-CQKIPVEADFLYAYSTAP-- GYYSWRNSKDGSWFIQSLCAMLKLYA-------HKLEFMHILTRVNRKVATE---FESFS LD-SAFHGKKQIPCIVS-----MLTKELYLYH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MDNNETSVDSKSI-----------NNFE---TKTIHGSKSMD---- SGIYLDSSYKMDYPEMGLCIIINNKNFH-------KSTGMSARNGTDVDAAN-LRETFMA LKYE-VRNKNDLTREEIMELMDSVSKE-DHS--KRSSFVCVILSH--GDE-------GV- IFGTNG-PVDLKKLTS---FFRGDYCRSLTGKPKLFIIQ--ACR----GTELDCGIET-- ----DSGT--------------------------DDDMA-CQKIPVEADFLYAYSTAP-- GYYSWRNSRDGSWFIQSLCAMLKLYA-------HKLEFMHILTRVNRKVATE---FESFS LD-ATFHAKKQIPCIVS-----MLTKELYFYH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SKKKKNVSGQSIKTT--- RDRVPTYQYNMNFEKMGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFQS LGFD-VIVHNDCSCAKMKDLLKKASEE-DHT--NAACFACILLSH--GEE-------NL- IYGKDG-VTPIKDLTA---HFRGDRCKTLLEKPKLFFIQ--ACR----GTELDDGIQA-- ----DSGPIN-----------------------DTDANP-RYKIPVEADFLFAYSTVP-- GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIMQILTRVNDRVARH---FESQS DD-PCFHEKKQIPCVVS-----MLTKELYFSH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MADDQDCGMEQAAGDSESPDAVDARPDRSSFV------PSLFSRKKKNDSGRSIKTA--- QDQVPTYQYNMNFEKVGKCIIINNKNFD-------KTTGMGVRNGTDKDAEA-LFKCFRN LGFD-VVIYNDCSCAKMQDLLKKASEE-DHR--NSACFACILLSH--GEE-------NL- IYGTDG-MTAIKDLTA---HFRGDRCRTLLEKPKLFFIQ--ACR----GTELDDGVQA-- ----DSGPIN-----------------------DTDANP-RYKIPVEADFLFAYSTVP-- GYYSWRSPGSGSWFVQALCSTLNEHG-------KSLEILHILTRVNNRVARH---FESQS DD-PHFHEKKQIPCVVS-----MLTKELYF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MTDDQDCAAELEMADSSTEDGVDAKPDRSTII------SSLLWKKKKNASMCPVSTT--- RDRVPTYLYRMDFEKMGKCIIINNKNFD-------KATGMDVRNGTDKDAEA-LFKCFRS LGFE-VTVYNDCSCAKMQDLLRRASEE-DHS--NSACFACVLLSH--GEE-------NL- IYGKDG-VTPIKDLTA---HFRGDRCKTLLEKPKLFFIQ--ACR----GTELDDGIQA-- ----DSGPIN-----------------------DTDANP-RYKIPVEADFLFAYSTVP-- GYYSWRNPGKGSWFVQALCSILNEHG-------KDLEIMQILTRVNDRVARH---FESQS DD-PRFNEKKQIPCMVS-----MLTKELYFGR---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MSPRNGTDVDAAD-AFRTFSK LGYK-VTVANDQTVDQMIQLLVKVSKQ-DHS--NSASFVCVLLSH--GDE-------GV- IYGTDG-FEKLDDLTK---FFKGDRCRSLVGKPKLFFIQ--ACR----GTELDEGSQI-- ----EADS--------------------------VGGQT-SDRIPVEADFLYAYSTAP-- GYYAWRNTQNGSWFMQSLCEMLRRFS-------GQLELMQIMTRLNHRVALH---FESSS DT-PGYSGKKQIPCIVS-----MLTKDFYF-PK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENTENSVDSKSI-----------KNLE---PKIIHGSQSMD---- SGISLDNSYKMDYPEMGLCIIINNKNFH-------KSTGMTSRSGTDVDAAN-LRETFRN LKYE-VRNKNDLTREEIVELMRDVSKE-DHS--KRSSFVCVLLSH--GEE-------GI- IFGTNG-PVDLKKITN---FFRGDRCRSLTGKPKLFIIQ--ACR----GTELDCGIET-- ----DSGV--------------------------DDDMA-CHKIPVEADFLYAYSTAP-- GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFMHILTRVNRKVATE---FESFS FD-ATFHAKKQIPCIVS-----MLTKELYFYH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >H_sapiens_ENSP00000311032 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENTENSVDSKSI-----------KNLE---PKIIHGSESMD---- SGISLDNSYKMDYPEMGLCIIINNKNFH-------KSTGMTSRSGTDVDAAN-LRETFRN LKYE-VRNKNDLTREEIVELMRDVSKE-DHS--KRSSFVCVLLSH--GEE-------GI- IFGTNG-PVDLKKITN---FFRGDRCRSLTGKPKLFIIQ--ACR----GTELDCGIET-- ----DSGV--------------------------DDDMA-CHKIPVEADFLYAYSTAP-- GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFMHILTRVNRKVATE---FESFS FD-ATFHAKKQIPCIVS-----MLTKELYFYH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QVNGA RLTSAQDVA--AEEGGPTGDQTDAKPDRRGRFLLFGNIKKNKDGQTREQDYSSESHY--- RVVSPTFQYKMSHQRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGE-LFKCFKS LGFD-VFIYNDQTCGKMESLLREASEE-DHS--DSSCFACILLSH--GEE-------GM- IYGTDA-AMPIKSMTS---LFRGDMCKSLVGKPKLFFIQ--ACR----GSEFDDGIQT-- ----DSGPPNDTL--------------------ETDANP-RHKIPVEADFLFAYSTVP-- GYYSWRNPGRGSWFVQALCNVLNEFG-------KQLEIMQILTRVNYMVATS---FESWS ED-PRFSEKKQIPCVVS-----MLTKELYFN----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_domestica_ENSMODP00000005556 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MEDTGTTVDAKST-----------KNSG---VKLFHGSKSVE---- SGLS-SDSYKMDYPEMGLCIIINNKNFH-------PNTGMSFRSGTDVDAAS-LSDTFRS LKYE-VRIKNDLTCNEITELLNSVSKE-DHS--QRSSFICVILSH--GEE-------GV- IFGTDR-SVELKRLTC---FFRGDKCRSLTGKPKLFIIQ--ACR----GTELDCGVET-- ----DSGT--------------------------DEDIA-CQKIPVEADFLYAYSTAP-- GYYSWRNSKDGSWFIQALCAVLKQHA-------HKLEIMQILTRVNRKVATE---FESYS LD-ISFHAKKQVPCIMS-----MLTKELYFSH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENTENSVDSKSI-----------KNLE---PKVIHGSKSMD---- SGISLDNSYKMDYPEMGLCIIINNKNFH-------KSTGMASRSGTDVDAAN-LRETFRN LKYE-VRNKNDLTREEIVELMRDVAKE-DHS--KRSSFVCVLLSH--GEE-------GI- IFGTNG-PVDLRKITN---FFRGDRCRSLTGKPKLFIIQ--ACR----GTELDCGIET-- ----DSGV--------------------------DDDMA-CHKIPVEADFLYAYSTAP-- GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFMHILTRVNRKVATE---FESFS LD-ATFHAKKQIPCIVS-----MLTKELYFYH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------SMQMAG EPTEISDLGGEVEEGGQSEDDVDAKPDRKGRFLLFKS-KKNKDGQMREQDYCSESHY--- RIVSPTFQYKMSHQRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGE-LFKCFKT LGFD-VFIYNDQTCEKMERLLREASEE-DHS--DSSCFACILLSH--GEE-------GM- IYGTDG-AMPIKTMTS---MFRGDMCKSLVGKPKLFFIQ--ACR----GSEFDDGIQT-- ----DSGPPNDTM--------------------ETDANP-RHKIPVEADFLFAYSTVP-- GYYSWRNPGRGSWFVQALCNVLSEFG-------KQLEIMQILTRVNYMVATS---FESWS ED-PRFSEKKQIPCVVS-----MLTKELYFKQC--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_musculus_ENSMUSP00000026062 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MTDDQDCAAELEKVDSSSEDGVDAKPDRSSII------SSILLKKKRNASAGPVRTG--- RDRVPTYLYRMDFQKMGKCIIINNKNFD-------KATGMDVRNGTDKDAGA-LFKCFQN LGFE-VTVHNDCSCAKMQDLLRKASEE-DHS--NSACFACVLLSH--GEE-------DL- IYGKDG-VTPIKDLTA---HFRGDRCKTLLEKPKLFFIQ--ACR----GTELDDGIQA-- ----DSGPIN-----------------------DIDANP-RNKIPVEADFLFAYSTVP-- GYYSWRNPGKGSWFVQALCSILNEHG-------KDLEIMQILTRVNDRVARH---FESQS DD-PRFNEKKQIPCMVS-----MLTKELYFSR---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAG EAAGIPELGGEAEGEHRCEDDVDAKPDRRGRFLLFKS-KKKNDGQMREQDYCSESHY--- RIVSPTFQYRMSHQRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGE-LYKCFKS LGFD-VFIYNDQTCEKMEHLLREASEE-DHS--DSSCFACILLSH--GEE-------GM- IYGTDG-AMPIKTMTS---MFRGDMCKSLVGKPKLFFIQ--ACR----GSEFDDGIQT-- ----DSGPPNDTM--------------------ETDANP-RHKIPVEADFLFAYSTVP-- GYYSWRNPGRGSWFVQALCNVLNEFG-------KQLEIMQILTRVNYMVATS---FESWS ED-PRFSEKKQIPCVVS-----MLTKELYFKPC--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENTENSVDSKSI-----------KSLE---PKIIHGSKSVD---- SGISLENSYKMDYPEMGLCIIINNKNFH-------KSTGMASRSGTDVDAAN-LRETFIN LKYE-VRNKNDLTREEIVELMRNVSKE-DHS--KRSSFVCVLLSH--GEE-------GI- IFGTNG-PLDLKKITS---FFRGDCCRSLTGKPKLFIIQ--ACR----GTELDCGIET-- ----DSGV--------------------------EDDMA-CHKIPVEADFLYAYSTAP-- GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFMHILTRVNRKVATE---FESFS LD-ATFHAKKQIPCIVS-----MLTKELYFYH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_gallus_ENSGALP00000014503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKKNGEEEQPKSSLSNQY--- RIVTPTFQYNMNYKKVGKCIIINNKNFE-------DKTGMGTRNGTDKDAGD-LSKSFRS LGFD-VYTYNDRSCEDMQTLLKQAAEE-NHS--DAACFACILLSH--GEE-------GL- IYGTDG-PMAIKHLTT---LFRGDKCKTLIGKPKLFFIQ--ACR----GSEFDEGIQT-- ----DSGPANDTL--------------------ETDANP-RYKIPVEADFLFAYSTVP-- GYYSWRNPGRGSWFVQSLCSVLNEHG-------KQLEIMQILTRVNYVVATN---FESQS DD-PRFSEKKQIPCVVS-----MLTKELYF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_guttata_ENSTGUP00000011206 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKKNGEEEQPKPSLSNQY--- RIVTPTFQYNMDYKKVGKCIIINNKNFE-------DKTGMGTRNGTDKDAGD-LAKSFKN LGFE-VDIHHDRSRDDMEKLLKKAAEE-NHS--DAACFACILLSH--GEE-------GL- IYGTDG-PMAIKSLTA---LFRGDKCKSLIGKPKLFFIQ--ACR----GSEFDEGIQT-- ----DSGPANDTL--------------------ETDANP-RYKIPVEADFLFAYSTVP-- GYYSWRNPGRGSWFVQSLCSVLNEHG-------KQLEIMQILTRVNYVVATN---FESQS DD-PRFSEKKQIPCVVS-----MLTKELYF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_rerio_ENSDARP00000019984 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MDKEALTSENEVSGDDQENYGKGDVTDAKPDPKAMCRVDKE ALTSEIEVLEEDQDSYGEEDVTDAKPDRKGRFRLFGN--FKKNDGKLQEKGESESHY--- RIVSPTFQYKMSHQRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGE-LFKCFKS LGFD-VAVYNDQTCRNMERLLKAVSEE-DHS--DSSCFACILLSH--GEE-------GM- IYGTDG-AMPIKTMTS---LFKGDVCKSLVGKPKLFFIQ--ACR----GSEFDDGVQT-- ----DSGPPNDTI--------------------ETDANP-RHKIPVEADFLFAYSTVP-- GYYSWRNPGRGSWFVQALCNVLSEFG-------KQLEIMQILTRVNYMVATS---FESWS ED-PRFSEKKQIPCVVS-----MLTKELYFN----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >B_taurus_ENSBTAP00000021099 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENTENSVDSKSI-----------KTSE---TKILHGSKSMD---- SGISLEESYKMDYPEMGLCIIINNKNFH-------ENTGMCRRSPTDDSVAQ-XRETFMN LKYE-VRIKNDLTCKEMLELMSNVSKE-DHS--KRSSFICVLLSH--GEE-------GI- IFGTNG-PVNLKKLAS---FFRGDYCRSLTGKPKLFIIQ--ACR----GTELDCGIET-- ----DSGA--------------------------EDDMA-CQKIPVEADFLYAYSTAP-- GYFSWRNAKNGSWFIQALCEMLKKHA-------HRLELMHILTRVNRKVAIE---YESFS TD-SAFHAKKQIPCIMS-----MLTKELYF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_anatinus_ENSOANP00000002508 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MADDQAPTMHQKECDFEDEVDAKPERLKVAQLF---SKKKNEAESQSGGPLPVRN--- RVVSSSFIYNMKYENLGKCIIINNKNFA-------SKTGMSTRNGTDKDAGN-LQKCFRS LGFD-VSVFNDFSCNQMKEILQKASEE-NHE--NSACFACILLSH--GEG-------DC- IYGTDD-FIPIKELTI---LFRGDKCKSLLGKPKLFFIQ--SCR----GTEFDDGIQT-- ----DSTPVT-----------------------DSDANP-GCRIPVEADFLFAYSTVPVK GYYSWRNVDRGSWFVQALCSVLHEHG-------KELEIMQLLTRVNHQVAIN---FESQA SD-PRYCQKKQIPCLVS-----MLTKELYF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------STKKKKTEDPEKPPQASDNV--- RIVTPAFQYKMNYGKVGRCIIINNKNFD-------DITGMSPRNGTDIDARD-LLRCFKG LGFD-VTVFNNKSCTEMETLLRSVAEQ-DHK--DSACFACIFLSH--GEE-------GL- IYGTDG-AMPIKVLTT---LFRGDKCRSLVGKPKLFFIQ--ACR----GCEFDDGLET-- ----DAGPSNDSL--------------------ETDANP-RHKIPVEADFLYAYSTVP-- GYYSWRNPGRGSWFVQALCNVLNEHG-------KELEVMQILTRVNYLVATQ---FESYC DD-PQFNKKKQIPCVVS-----MLTKELYFKPC--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----PTFRYRMDYKKLGKCVIINNKNFA-------KDTGMRIRNGTDKDAGD-LQKCFRG IGFD-VSIYNDLTCDNMEKILGEAALE-NHD--DAACFACILLSH--GEE-------GL- IYGTDG-CMAIKNLTG---LFRGDKCQSLIGKPKLFFIQ--ACR----GSEFDAGIQT-- ----DSGSSNDNL--------------------EMDANP-RYKIPVEADFLYAYSTVP-- GYFSWRNPGKGSWFVQSLCSVLNDHG-------KELEVLQILTMVNYKVARN---YESQS DD-PRFSQKKQVPCVVS-----MLTKELYF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----DKYRYKMDYPCMGTCVIINNKTFD-------PKTGLSPRNGTDVDAAE-LEKTFSR LGYK-VTVANDQTADQMVDLLADVSKQ-DHR--KSASFVCALLSH--GDE-------DG- IYGTDG--TSLDDLTK---FFKGDRCRSLVGKPKLFFIQ--ACR----GTDTDRGVNF-- ----DADS--------------------------TDGQM-LQSIPLEADFLYAYSTPS-- GYYSWRNTQNGSCFMQSLCEILHSFS--------QLELMQIMTRVNYEVALH---FESSS DK-LGYSGKKQIPCIMS-----MLTKDFYF-PK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MADDQGCVXXXXXXXXXXXXXXXXXXXXXXXX------XXXXXXXXXXXXXXXXXXX--- XXXXXXXXXXXXXXXXXXXXXXXXXXFD-------KVTGMGVRNGTDKDAEA-LFKCFRS LGFD-VIVYNDCSCAKMQDLLKKASEE-DHT--NAACFACILLSH--GEE-------NV- IYGKDG-VTPIKDLTA---HFRGDRCKTLLEKPKLFFIQ--ACR----GTELDDGIQA-- ----DSGPIN-----------------------DTDANP-RYKIPVEADFLFAYSTVP-- GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIMQILTRVNDRVARH---FESQS DD-PRFHEKKQIPCVVS-----MLTKELYFSQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MDKLYRDV--- QSGEDKYRYKMDYPCMGTCVIINIKNFD-------LKTGLETRNGTDVDAAE-LEKTFSK LGYK-VTLVHDQTADQIVDLLRDVSTQ-DHS--NSGSFVCVLLSR--GDE-------GG- IYGTDGSFVNLDELTK---FVDGNGCRSLVGKPKLLFIQ--AAR----GNKLDDGTLS-- ----EGDS--------------------------MDGQT-PSRIPVEADFLYAYSTTP-- GFNAWRDTQNGSWFMQSLCEMLRRFS-------GQLELMQIMTRVNNKVALE---YKTT- ---PGRSGKRQMPCIVS-----LLTKEFYF-P---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_domestica_ENSMODP00000005560 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MEDTGTTVDAKSI-----------KNSG---VKSLHSSKSVE---- SGLS-SDSYKMDYPEMGLCVIINNTHFH-------NDTELSPRTGSDKDAAN-LIDIFRS LKYE-VRNKNNLTRDKMIELLRQVSEE-DHS--QRSSFVCVILSH--GEE-------GV- IFGTDD-SVELKELTY---FFKGYKCKSLTGKPKLFIIQ--ACQ----GREFDCGVET-- ----DSGT--------------------------DEDVA-CHKIPVEADFLYAYSTVP-- GYYSLRDPKDGSWFIQALCAVLKQHA-------HKLEIMQILTRVNRKVATE---FESYS SK-ASLHAKKQMPCIMS-----MLTKELYFSH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >R_norvegicus_ENSRNOP00000040783 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENNKTLVDSKSI-----------NYFE---VKT-HRSKPMD---- SGVDLNSSYKMGYSKMGLCIIINNKNLL-------K-TEMTSRSGTDVAAANRMSETFMV LKYK-VRNKNDLTHEEIMELMDNVSKE-DHS--ERSSFVCVIPRH--GDK-------GL- IFGTNR-PVDLEKLTS---FFRDDYCQSLTGKKKLFITQ--DCQ----GTELDCGIET-- ----DSGT--------------------------EDGMS-CQKIPVEANFLYVYSTKP-- NYYSW------SWFIHSLCTMLQLCT-------HKLEFMHILTHANRKVATE---FKSFS LG-GTFHKKKQIPCILS-----MLPKELYFYH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_guttata_ENSTGUP00000014729 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------FACILLNH--GEE-------GL- IYGTDG-PMAIKSLTA---LFRGDKCKSLIGKPKLFFIQ--ACR----GSEFDEGIQT-- ----DSGPANDTL--------------------ETDANP-RYKIPVEADFLFAYSTVP-- GYYSWRNPGRGSWFVQSLCSVLNEHG-------KQLEIMQILTRVNYVVATN---FESQS DD-PRFSEKKQIPCVVS-----MLTKELYF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_domestica_ENSMODP00000012376 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------FPRKKKNVPEKSNQPQPEYK--- RIVMPTFQYNMDYKKVGKCIIINNKQFD-------SKTGMGTRNGTDKDAEG-LTKCFRS LGFD-VIVYNNRSCSDMRNLLKQGEPE------------CLFLHHISGEK-------SV- IYSDQC-GIIPEKKTGTDISYRGRGCSV------CFFKK--ACR----GTEFDDGIQT-- ----DSGPIN-----------------------DTNANP-GCKIPVEADFLFAYSTVP-- GYYSWRSQAKGSWFVQALCSVLNEHG-------KSLEIMQILTRVNYMVAMD---FESQS DN-PCFNEKKQIPCMVS-----MLTKELYF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >C_intestinalis_ENSCINP00000011493 ------------------------------------------------------------ ------------------------MDPHPADFPEPPPQPRITLRSDTVDSSVFHDDDNLF SMDDAVEQPDSFDAVPPNSYPSPNSSLSTSYSGGDILS---------------------- ----------------------------------------------------------MA SPPLPVTRITERTQTAGEVIRTYNPSPEKRDHEVSYDELLEED----------------- -------------------------------------------------MKFSAEGVSDS VKHFYGAAIPVTCDDRVDTGAGYDTVDAGADYGSDAGPDNSDTGPPLPYKQKSKVIEPEA IAVNREFQYPMNHKQRGCCIIFNQKHFD-------AHLRMDTREGTNHDAEN-IKHSMEM LGFEHVRIIKDSTKVEIINWIAAVSKA-DHS--NYDCFACVILTH--GGD-------KDV LYARDD-KMELKDFMQ---PFRGDNCPSLATKPKLFFIQ--ACR----GFKLAEPVKVRP VQC-DSLNYDTTDGG------------------SATVDE-FATIPAEADFLIAQSTVP-- KYYSWRNKSNGSIFIQALCLTFNLFG-------EKQEIMQMMTKVNRMVAYD---YESAS KD-PKMNQKKQIPSITT-----QLTAELYF-PKKREGHPSASEYSVNQQVTSPRQLQHNQ VTARCEYDQYSSHTVRASDNAFVETTTQFSRLAMQAGDASRLEEAYMDPRTQGAAANPPS HASVRQRDLFPRPPPLPTKQRQTRRSNDSSHRRSGDYTTRRPPQEVYSSPTGSPRDVTPH YVTGYDAPPRRSSHETSPYGSQHNVARRRPSYETSFPAGSRAIPAVTLRKQSLPVSSMYS SSADSHLLTPNRHLHPSETVPARLSVSPNAARNSVNRRSLPLGTDPKPQAVSSWGSGINR AGLRSTKQTEV >M_domestica_ENSMODP00000005512 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------NDLTCN---ELLDSVSKE-DHS--QSSSFIGAVLSH--GEE-------GV- IFGPDE-SVELKRLMC---FFRGDKCRRLRGKPKLLIIQ--ACR----GTELDCG-ET-- ----DSGT--------------------------DEDIA-CQKIPVEADFLYAYSTAP-- GSYSWGNSKGGWWFIQALCA----HA-------HEFEIMQILTRVNGKVATE---FESYS LD-ISFHAKKQVPCITS-----ILTKKL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_gambiae_AGAP011952-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ENYDTSHRNRGTALIFNHVNFE----------SNAKREGSNKDRDE-IKKELLQ LGFD-ARVFNDLKKQELLAKLDEVAKE-DHT--ESDCFVLVMMTH--GQD-------GS- LYAADK-QYQIAELWE---PFVGDACKTLIGKPKLFFVQ--ACR----GTKFDKGVKL-T KIATDTVDAL-----------------------SSSSQR-TCVIPTMADVLVMYSAFD-- GHYSWRNPTHGSWFIQSLSIELNQHA-------HRKELLQLLTSVSRRVAYL---YESNV PGNEQMDGKKQMPCVVS-----MLTKALYF-PRK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MTETDGFYRSR EVLDPAEQYKMDHKRRGTALIFNHERFF-------WHLALPERRGTNADRDN-LTRRFSE LGFE-VKCFNDLRAEELLLKIHEVSTS-SHV--DADCFLCVFLSH--GEG-------NH- IYAYDA-KIEIQTLTG---LFKGDKCQSLVGKPKIFIIQ--ACR----GSQHDVPVVPL- ----DVVDHQTDKLDDNVT--------------QVDAAS-VYTLPAGADFLMCYSVAE-- GYYSHRETVNGSWYIQDLCEMLARHG-------SSLEFTELLTLVNRKVSQR---RVDFC KD-PGAIGKKQVPCFAS-----MLTKKLHF-CPKPSK----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_rerio_ENSDARP00000072390 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AFEPYKKHKNIGKCLIISNEHFP-------VQFSLNRKKGNSVDERR-LSSTFKS LGFH-VKVENNLSANQMIDALRTVSEE-DHT--DNSCFVCVLMSH--GEE-------GT- ILGSDERWIPVKTLTS---LLTSDLCPSLRDKPKIFFLQ--ACR----GVEYDPGVEA-- ----DSVEA------------------------SEDFFG-ISDVP-ELDFLCCYSTVE-- GYFAWRNPETGSIFIRELCKTLMD---------CRLEIIQILTRVNHLVAYY---FQSYT LE-LETNRKRQMPCFAS-----RLTKDFYL-HV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MSS--ASGLRRGH-----------PAGGEENMTETDAFYK-R EMFDPAEKYKMDHRRRGIALIFNHERFF-------WHLTLPERRGTCADRDN-LTRRFSD LGFE-VKCFNDLKAEELLLKIHEASTV-SHA--DADCFVCVFLSH--GEG-------NH- IYAYDA-KIEIQTLTG---LFKGDKCHSLVGKPKIFIIQ--ACR----GNQHDVPVIPL- ----DVVDNQTEKLDTNIT--------------EVDAAS-VYTLPAGADFLMCYSVAE-- GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFTELLTLVNRKVSQR---RVDFC KD-PSAIGKKQVPCFAS-----MLTKKLHF-FPKSN------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_musculus_ENSMUSP00000029626 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MTETDGFYKSR EVFDPAEQYKMDHKRRGVALIFNHERFF-------WHLTLPERRGTNADRDN-LTRRFSD LGFE-VKCFNDLRAEELLLKIHEVSTS-SHI--DADCFICVFLSH--GEG-------NH- VYAYDA-KIEIQTLTG---LFKGDKCQSLVGKPKIFIIQ--ACR----GSQHDVPVVPL- ----DMVDHQTDKLD-NVT--------------QVDAAS-VYTLPAGADFLMCYSVAE-- GYYSHRETVNGSWYIQDLCEMLARYG-------SSLEFTELLTLVNRKVSQR---RVDFC KD-PDAIGKKQVPCFAS-----MLTKKLHF-CPKPSK----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_rerio_ENSDARP00000050929 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MASHTKSDGSAAVEKDSASA---GQTVEENLTETDSFNQSI FSMDPNQEYDMNHKRRGMALIFNHENFF-------WKLGLGYRSGTNADKEN-LIRRFRE LNFE-VKAFDDYKRHEVLSKITEAAAA-DHV--DADCFVCVFLSH--GEN-------GH- VYANDG-QIEIPEITD---LFKGDKCRSLVGKPKIFIWQ--ACR----GDKHDDPVTPM- ----DVVDSQ----VTNDM--------------VVDAGV-LYTLPAGADFIMCYSVAE-- GYYSHRETVNGSWYIQDLCEILRRYG-------SELEFAEILTLVNRKVSLR---SVLNC KD-RSAVGKKQVPCFAS-----MLTKKLFF-RPKK------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >H_sapiens_ENSP00000265164 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MSS--ASGLRRGH-----------PAGGEENMTETDAFYK-R EMFDPAEKYKMDHRRRGIALIFNHERFF-------WHLTLPERRGTCADRDN-LTRRFSD LGFE-VKCFNDLKAEELLLKIHEVSTV-SHA--DADCFVCVFLSH--GEG-------NH- IYAYDA-KIEIQTLTG---LFKGDKCHSLVGKPKIFIIQ--ACR----GNQHDVPVIPL- ----DVVDNQTEKLDTNIT--------------EVDAAS-VYTLPAGADFLMCYSVAE-- GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFTELLTLVNRKVSQR---RVDFC KD-PSAIGKKQVPCFAS-----MLTKKLHF-FPKSN------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_gambiae_AGAP009832-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------QPLTKAFSAMFSRKQEDSSDTRGMPHGSPIASGSQTANGIIRPAY VIERYAAYYPMNHKRRGMALIFSHNKYN------VRNVSLPVREGSAIDCKR-LKETLEL FRFD-VKVYPDFKLEEIKSVIGKVSSM-DHS--DSDCFLVAILTH--GED-------GGI VYAYDQ-PYELSLIWS---FFTADNCPSLAGRPKIFVVQ--ACR----GNQLDHGVKV-- ---------------------------------QKDGVA-RYSIPTHADFLFAYATIP-- GFMAFRNTTEGSWFINELCKELQENG-------HRYDINTLLTFVTQKVAYD---HESVS NM-PEYNMRKQTPCVVS-----MLTRLLLF-NVV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SSA--TCGLRRAY-----------RTADEQNVTETDAFYK-R EMFDPEEKYKMDHKRRGIALIFNHERFF-------WHLTLPDRRGTSADRDN-LVRRFSE LGFE-VKCFNDLKAEELLLKIHEASTS-SHI--DADCFLCVFLSH--GEG-------NH- IYAYDA-KIEIQTLTG---LFKGDKCQSLVGKPKIFIIQ--ACR----GDQHDVPVLPL- ----DVVDHRTDKLEDNVT--------------EVDAAS-VYTLPAGADFLMCYSVAE-- GYYSHRETVNGSWYIQDLCEMLGKFG-------SSLEFTELLTLVNRKVSQR---RVDFC KD-PNAIGKKQVPCFAS-----MLTKKLHF-FPKSK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MSDT--TGDGRGGRVASPNKAATD-RAACTENLTETDALI--R SSLDPAEEYKMDNKRRGLALIFNQERFF-------WRLGLNDRHGTNADRYN-LERRLSN LNFD-VRAYDNLKQEEVLNKINEAAEE-NHS--DSDCFLLVFLSH--GEN-------DQ- VYTYDG-KISVQDITS---LFKGDKCKSLVGKPKIFILQ--ACR----GDKHDDPVTAC- ----DAVDSE---LKTNEV--------------VVDASV-LHTLPAGADFIMCYSVAE-- GYYSHRETINGSWYIQDLCELLQRYG-------DSHEFTEVLTLVNRKVSMR---SVGNS SD-RSAIGKKQVPCFAS-----MLTKKLYF-RPKQ------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MSS--VSGLRRGH-----------PAGGEENMTETDAFYK-R EMFDPAEKYKMDHRRRGIALIFNHERFF-------WHLTLPERRGTCADRDN-LTRRFSD LGFE-VKCFNDLKAEELLLKIHEVSTV-SHA--DADCFVCVFLSH--GEG-------NH- IYAYDA-KIEIQTLTG---LFKGDKCHSLVGKPKIFIIQ--ACR----GNQHDVPVIPL- ----DVVDNQTDKLDTNIT--------------EVDAAS-VYTLPAGADFLMCYSVAE-- GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFTELLTLVNRKVSQR---RVDFC KD-PSAIGKKQVPCFAS-----MLTKKLHF-FPKSN------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_melanogaster_FBpp0071971 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MTDECVTRNYGVGIRS PNGSENRGSFIMADNTDAKGCTPESLVVGGA--------------TAASPLPANKFVARM PVERYASEYNMSHKHRGVALIFNHEFFD--------IPSLKSRTGTNVDAQE-LKKAFEN LGFA-VSVHKDCKLRDILKHVGKAAEL-DHT--DNDCLAVAILSH--GEH-------GY- LYAKDT-QYKLDNIWH---YFTATFCPSLAGKPKLFFIQ--ACQ----GDRLDGGITLEK ----GVTET------------------------DGESST-SYKIPIHADFLFSYSTIP-- GYFSWRNINNGSWYMQSLIRELNANG-------KKYDLLTLLTFVNQRVALD---FESNV PATPMMDRQKQIPCLTS-----MLTRILRF-GDKPNGNKAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_anatinus_ENSOANP00000005811 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------PRGA--TRLARGHP-----------AAGGAPNVTEVDGFYD-R ETFDPAAKYKMEYKRRGVALIFNHERFY-------WQLKLPDRHGTRADREN-LIRRLSA LGFE-VKCFDDLKAEEVMLKIHQASSS-NHA--DADCFLCVFLSH--GQG-------NH- VYAYNG-KIDIPEMTS---MFKGDQCRSLVGKPKIFIFQ--ACR----GEQHDVGVVPL- ----DVVDSKISEQDVNET--------------EVDAAS-VYTLPAGADFLMCYSVAE-- GYYSHRETVNGSWYIQDLCEMLGRYG-------SSLEFTELLTLVNRKVSYR---RVDFC KD-PSLIGKKQVPCFAS-----MLTKKLHF-LPKAQ------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_latipes_ENSORLP00000005993 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MSHQRVGKCIIINNKNFD-------DNTGMNVRNGTDRDAGE-LYKCFKS LGFD-VSIYNDQTCDKMEHLLKEASQE-DHS--DSSCFACILLSH--GEE-------GM- IYGTDG-AIPIKTMTS---LFRGDKCKSLVGKPKLFFIQ--ACR----GSEFDEGVQT-- ----DSGPPNDTI--------------------ETDANP-SHKIPVEADFLFAYS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_melanogaster_FBpp0084848 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MDATNNGESADQVGIRV GNPEQPNDHTDALGSVGSGGAGSSGLVAGSSHPYGSGAIGQLANGYSSPSSSYRKNVAKM VTDRHAAEYNMRHKNRGMALIFNHEHFE--------VPTLKSRAGTNVDCEN-LTRVLKQ LDFE-VTVYKDCRYKDILRTIEYAASQ-NHS--DSDCILVAILSH--GEM-------GY- IYAKDT-QYKLDNIWS---FFTANHCPSLAGKPKLFFIQ--ACQ----GDRLDGGVTMQR ----SQTET------------------------DGDSSM-SYKIPVHADFLIAYSTVP-- GFYSWRNTTRGSWFMQSLCAELAANG-------KRLDILTLLTFVCQRVAVD---FESCT PDTPEMHQQKQIPCITT-----MLTRILRF-SDKQLAPAGRV------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GSDAELGKTATD-SSACTGDLMETDAISGSI GFLDPAEEYKMDNKRRGLALIFNQERFF-------WRLGLRDRHGTNADSYN-LQRRLKE LNFE-VKVFDNHTQAQVLEIITSAAKD-DHS--NVDCFLVVFLSH--GEN-------DH- IYTFDD-KINVQDITS---LFKGDKCKSLVGKPKIFILQ--ACR----GDKHDEPATAAA F---DDVDSE---LKKNEV--------------EVDASA-VYTLPAGADFIMCYSVAE-- GYYSHRETVNGSWYIQDLCDLLRKYG-------DSLEFTELLTLVNRKVSMR---SVGYC SD-PNAIGKKQVPCFAS-----MLTKKLYF-RPKK------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_aegypti_AAEL014348-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MKKIMFGRKEVNSPQQMIPTVAPAY TIERYSAYYPMNHKHRGKAIIFAHSVFA------VKNVNLPNRDGSDVDCEM-LVESLKR LHFD-VTLYKDYRLKDILLVIEKVSLM-DHS--NSDCLLVAVLSH--GDE-------GEV IYAHDC-PYQISSIWT---QFTGDRCRTLVGKPKIFIIQ--ACR----GNDLDSGVKV-- ---------------------------------EKDGVA-RYSIPTNADFLFAFATIP-- GYMSFRNTKNGSWFIRELCNELNENG-------QRYDMLTLLTFVVQKVAYG---YESYA PVHPDHHMKKQTPCVVS-----MLTRLLLF-NNV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >E_caballus_ENSECAP00000013268 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GEEQNMTEIDAFYK-R EMFDPAEKYKMDHKRRGIALIFNHERFF-------WHLTLPDRRGTSADRDN-LMRRFSD LGFE-VKCFNDLKAEELLLKIYEVSTS-SHA--DADCFVCVFLSH--GEG-------NH- IYAYDA-KIEIQTLTG---LFKGDKCQSLVGKPKIFIIQ--ACR----GDQHDVPVTPL- ----DVVDHGTDKLDANVT--------------QVDAAS-VYTLPAGADFLMCYSVAE-- GYYSHRETINGSWYIQDLCEMLARFG-------SSLEFTELLTLVNRKVSQR---RVDFC KD-PSAIGKKQVPCFAS-----MLTKKLHF-FPKSK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MSLKSAAD VLMSGVPTPHTNENNNVGQSEVDALG-------------------SGETPRIYSLPDVTK MASSEVECYQMDRESRGLALIINNENFH-------HATRMNKRSGTDVDARN-LSRIFKK LGFD-VQVYKDLSCISMLEVINEVSTM-DHT--GNDCCFVAFLSH--GDD-------GC- VYGTDG-IVQIKKIVD---QFRGDVCPSLAGKPKIFLFQ--ACR----GTLHETSVQLSV ----DVVDGEDQPCV------------------EVDAAP-VPTLPSGSDYLFCYSVAE-- GYYSHRDTLYGSWFIQDFTDVMEQLVLNKGKQQDKVDFIDVLTVVNRKVSAR---RVERS YS-QQALGKKQMPCYLS-----MLTKKLYL-TPKK------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_guttata_ENSTGUP00000004278 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MSGS--ERRPPAGHVQLDSRP-TLPTTDGNENITEVDALNI-R QSLDPAEEYKMNHQRRGLALIFNHERFY-------WHLRLQDRRGTWVDRNN-LKSILTE LGFE-VRLFDDLKKEDVQQRIYEASTA-DHS--NADCFVCVFLSH--GED-------GH- IFAYDD-KIEIQTITD---MFRGDKCQSLVGKPKIFIIQ--ACR----GDKHDDAVIAH- ----DSADG--SESPGNET--------------DVDAAG-VYTLPAGADFIMCYSVAQ-- GYYSHRDTINGSWYIQDLCETLRKHG-------SSLEFAELLTVVNRKVSCR---RVGMC KD-INAIGKKQIPCFAS-----MLTKKLYF-HPKSK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >B_taurus_ENSBTAP00000016642 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MSS--EPPPRRAR-----------GPGEEQNMTEIDAFPR-R EIFDPTEKYKMDHKRRGIALIFNHERFF-------WHLTLPNRPGTSADRDN-LRRRFSD LGFE-VKCFDDLRAEELLLKIHEASTA-SHV--DADCFLCVFLSH--GEG-------NH- IYAYDA-KIEIQTLTG---LFKGDKCQSLVGKPKIFIIQ--ACR----GSQHDVPVIPL- ----DVVDHRTDTPDANLT--------------QVDAAS-VYTLPAGADFLMCYSVAE-- GYYSHRETVNGSWYIQDLCEMLGKFG-------SSLEFTELLTLVNRKVSQR---RVDFC RD-PNAIGKKQVPCFAS-----MLTKKLHF-SPKSK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------RMETDAFYGRN SIVDPAEEYKMDNKRRGLAIIFNQESFF-------WRLGLKDRHGTNADSYN-LQRRLRE LNFD-VNVYNNYKQQEVLDIINAAAKA-DHS--DVDCFLLVFLSH--GEN-------DH- IYANDD-KISIQDITS---LFKGDKCKSLVGKPKIFIWQ--ACR----GDKHDEPATAAA F---DDVDSE---SKKNEV--------------EVDASA-VHTLPAGADFIMCYSVAE-- GYYSHRETVNGSWYIQDLCDLLLRYG-------DSLEFTELLTLVNRKVSMR---SVGYC RD-PNAIGKKQVPCFAS-----MLTKKLYF-RPKKKSK---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_gambiae_AGAP004920-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------VCGRDILHCKTMNTSTLSTAFDEVDNNTRVLSLVASVPEIISSSVIHE LEPVDDAHYNMSHNRRGVAAVFNHRKFL----------HASERKGTDADCDN-IRQVLIY LQFE-VRVYDDLTRKEIKQVLDDLAEE-DHK--NSDCLLVVIMTH--GDD-------DV- LHAKDG-TFNVDRLWE---NFIGDSCPSLLGKPKLFFIQ--ACR----GSSFDTGVHF-S QCMTQVAKTVVPYAMRELPQPSIVPG-------CPKSSI-QYAIPSMADLLVMYSTYK-- GHYSWRNPSTGSWFIRALCDELREHG-------NSKELLQLLTSVSRRVAYE---FQSNV PNNSQIDCQKQMPCIVS-----MLTRRIYF-SKK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_domestica_ENSMODP00000007353 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------K--SFGLFFVF-----------EGDAEQNATEIDAFFK-S KPLDPAEQYKMDHKRRGVALIFNHERFF-------WHLTLPERRGTRADRDN-LRQRLSD LGFE-VNCFDDLKAEDLLMTIHMVSTS-SHI--DADCFLCVFLTH--GEG-------NH- IYAYDA-KIDIQKLTA---MFKGDKCQTLVGKPKIFVIQ--ACR----GDQHDIPVIPL- ----DVVDHLSDKVDVNET--------------EVDAAS-VYTLPAGADFLMCYSVAE-- GYYSHRETVHGSWYIQDLCEMLEKYG-------SSLEFTELLTLVNRKVSQR---RVDFC KD-PNAIGKKQVPCFAS-----MLTKKLYL-FPKPK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_gambiae_AGAP000830-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----MSMPDVVDIRNEINKEHVRESLDRNGDEQQLVQDVNDALGTRKGHDPTNHLVRARM PVERYACDYNMNHKRRGLALIFNHENFD--------VPQLRSRAGTNVDCEN-LTASLKG LDFE-VHVFKDLKLRDLQKEVERVSQM-DHS--DADCLLVTILSH--GEL-------GY- LYAKDC-QYKLDTIWT---YFTANHCPSLAGKPKLFFIQ--ACQ----GDQLDGGVVLEA K---DRTET------------------------DSSSSMLTFKIPMYADFMIAYSTIP-- GFYSWRNTQKGSWFIQSLCHELNQNG-------RKYDLMVLLTFVTQRVAYD---FESNT PDIPMMHQQKQIPCTTS-----MLTRLVYF-NQKK------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MASAKQQSSPSAGQIEKDSSSASQ-NKEQKANVAETDGWTSRT LELDPSAEYKMTHKRRGLALIFNHEDFY-------WQLRLGSRRGTNTDSMN-LNRILTD LGFD-VQNYYNLRTLDILEKIQEASTA-DHS--NADCFLCVFLSH--GED-------RH- IYSYDS-LIDIQELTN---SFKGDKCESLVGKPKIFIFQ--ACR----GEKHDNPVLPT- ----DETDSV---TLTNIT--------------EVDAAS-LYTLPAGADFIMCYSVAE-- GYYSHRETVNGSWYIQDLCEVLKAHA-------ASLEFTEILTLVNRKVSQR---SVAFC ND-PKAIGKKQIPCFSS-----MLTKKLFL-KPKSN------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_aegypti_AAEL003444-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MDTTDELDVLGFGSRTNESSKSIKEALV SRAALDEYYDTTNKRRGIALVFCHMNFS----------VMAKRNGADKDRDD-ICNTLYG LDFD-VRVFDDLSRKEVLDRLKDVSRE-DHS--DNDCLVVVMMSH--GEQ-------GV- LYARDN-KYNVDSLWK---NFVGNACPSLIGKPKMFFIQ--ACR----GEQFDEGVAYAA KSPKDMVD-------------------------SRQEQV-LYSIPAMADLLVMYSTYD-- GYYSWRNPRQGSWFIQSLCTELDENG-------RVRDLLTLLTGVSRRTAYE---FQSFV PHNAKMDAMKQIPCIVS-----MLTKTFYF-TKKTRSRVVTDID---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_rerio_ENSDARP00000041413 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MALIFNQKQFD-------WKLGLKTRNGTDKDRDDLVSRRFQE LNFE-VKAYNDYSRDDVLLKIQEASAA-DHV--DADCFVCIFLSH--GED-------GH- VYANDK-KIEIPEITD---LFKGDKCRSLVGKPKIFIWQKQACR----GDKLDDAVTEM- ----SVEDVE--------M--------------AVDAGV-LYTLPAGADFIMCYSTAE-- GFCSFREPLNGSWYIQDLCEILGRYH-------SELQFTDILTLVNMKVSLR---SVPNC RN-RAAIGKKQMPCFAS-----MLTKRLFF-RDNTQIQ---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_gallus_ENSGALP00000019870 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MSGA--ERRPAAGRVQLDSKPTPTTTADGNQNITEVDAFDK-R QTFDPAVQYKMNHQRRGVALIFNHEHFF-------WHLRLPDRRGTLADRNN-LKRSLTD LGFE-VRIFDDLKAEDVLKKVFEASRD-DYS--NADCFVCVFLSH--GEN-------DH- VYAYDA-QIKIETITN---MFRGDKCQSLVGKPKIFIIQ--ACR----GDKHDDPVLVQ- ----DSVDSK-DETTVNQT--------------EVDAAG-VYTLPAGADFIMCYSVAQ-- GYFSHRETVNGSWYIQDLCEALGKHG-------SSLEFTELLTVVNRKVSHR---KVDIC RD-INAIGKKQIPCFAS-----MLTKKLYF-HPKSK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRR-N HLFDPAAEYKMSHKRRGLALIFNHEHFF-------WHLMLPERRGTQADKEN-LKRGLTD LGFE-VKCFDDLKAEEVLQNIYNVSTD-EHD--DADCFLCVFLSH--GED-------DH- VYAYDA-KIEIKSLTN---MFKGDKCPSLVGKPKIFVIQ--ACR----GDKHDDPVIAR- ----DTVDSK-KELDINET--------------EVDTAA-VYTLPAGADFLMCYSVAE-- GYYSHRETINGSWYIQDLCEMLKRHG-------SSLEFTDLLTLVNRKVSHR---EVDVC KD-RKALGKKQIPCFAS-----MLTKKLYF-RPKFK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_gambiae_AGAP004921-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------RSCNLMDDLPPEPTPDNEFYDGNIPSITQTDQIASRQRSQN ARALQEEEYDTNHRRRGMAIILNHENFE----------LMSKREGTNRDRDA-ATAVLTS MQFD-VRVYNDLGRDELFCVLLALASE-DHS--DCDCLLVMLMTH--GDD-------DV- LYAYDG-PYSVDKLWE---SFMGNACTTLLGKPKLFFVQ--ACR----GSTFDKGVKLGC ----RDLDS------------------------DHFSSH-KYVIPTTADLLVMYSSYK-- GHVSWRSPRGGSWFIQALCVELETNW-------KHMELLQLLTGVSRRVAYD---YQSNE PSKGRMDAMKQMPSIVS-----MLTKLVYF-PLKLGS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_gambiae_AGAP011951-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ECYDTSNARRGIALIINQVIFS----------SMAVRVGSSKDRTD-ISTVLQR IGFE-VRVMDDPNRKQLLSALKQLAGE-DHS--HSDCLVVVVMTH--GKE-------NNL LYASDK-SYEANQLWE---PFIGDACPSLIGKPKLFFVQ--ACR----GKKLDEGVIQ-A TISIDSVDTQ-----------------------SSPGSM-RYVIPAMADLLVMYSTYD-- GHYSWRNPSKGSWFIQSLCAELGASA-------HCKELLHILTAVSRRVAYH---YQSNV PDNAKIDAKKQMPCMVS-----MLTKLLYL-RPKK------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------KYKMNHKERGCFMIFNQEVYD-----AKTSLNLGERIGSSTDARN-LASAAAY LGFEYIQVFNNLTRSKILKWLKDVAAA-SHE--SYDCFGCAILTH--GDK-------NNE LYARDA-SMNITDFTN---PFTADKCPTLAGKPKLFFVQ--ACR----GHKRDTAVPFTL ----NVAS-------------------------TIEKTE-LKLIPCQADFLIASSTPE-- GYSSWRNKANGSWFIQALYLCIQRY--------PSLEIMQIMTRVNRMVALH---FENTN T--ESPDIYKQIPSICT-----RLTGELYF-HKPGST----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_cuniculus_ENSOCUP00000011835 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MSS--APGLRGAR-----------LAGGKQNMTETDAFYK-R EVFDPAEEYKMDHRRRGIALIFNHERFF-------WHLMLPERRGTNADRDS-LARRFSD LGFE-VKCFNDLKAEELLLKIHEVSTS-SHL--DADCFLCVFLSH--GEG-------NH- IYAYDA-KIEIQTLTG---LFKGDKCQSRVGKPKIFIIQ--XXX----XXXXXXXXXXX- ----XXXXXXXXXXXXXXX--------------XXXXXX-XXXLPAGADFLMCYSVAE-- GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFTELLTLVNRKVSQR---RVDFC KD-PSAIGKKQVPCFAS-----MLTKKLHF-FPK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_rerio_ENSDARP00000093958 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MKHAKRGLALIFNQKDFS-------L-LGLKTRKGTDKDRDS-LVSRFEE LDFE-VKAYNDYSRDKVLKEIKEVAAA-DHV--DADCFVCIFLSH--GED-------GH- VYANDE-KIKIPEITD---LFKGDKCRGLVGKPKIFIWQNKACR----GDKKDDPVAPM- ----SAEDSD------DEM--------------AVDAGV-SNTLPAGADFIMCYSTTE-- GFCSFRDPLNGTWYIQDLCEIMGRYR-------SQLEFTNILTLVNRKVSLR---SI--C DD-LSATGTKQMPCFAS-----MLTKRLFF-RPKK------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_cuniculus_ENSOCUP00000005723 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------KIIHGSKSMD---- SGISLDNSYKMDYPEMGLCIIINNKNFH-------KNTXXXXXXXXXXXXXX-XXXXXXX XXXX-XXXXXXXXXXXXXXXXXXXXXX-XXX--XXXXXXXXXXXX--XXX-------XX- XXXXXX-XXXXXXXXX---XXXXXXXXXXXXXXXXXXXX--ACR----GTELDSGIET-- ----DSGV--------------------------DYDMA-CQKIPVEADFLYAYSTAP-- GYYSWRNSKEGSWFIQSLCAMLKEYA-------HKLEFMHILTRVNRKVATE---FESSS LD-ATFHAKKQIPCIVS-----MLTKELYFYH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_aegypti_AAEL012143-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------MM-DHS--EHDCVSITILSH--GEL-------GY- LYAKDC-QYKLDIIWS---YFTANRCPTLAGKPKVFFIQ--ACQ----GDQLDAGVTLA- ----ERTET------------------------DSAGSM-SYKIPAHADFLIAYSTIP-- GFYSWRNTQKGSWFMQSLCQELTQHG-------KKYDLLTLLTFVAQRVAYD---FESNT PDIPMMHQQKQIPCVTT-----MLTRLLRF-TEK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_mulatta_ENSMMUP00000037892 VEGGRRARVVTESKRNFFLGACPTPFPTEHVELGRLGGSETAMVPGKGGADYILLPFEEM DFNRNLYDIGEQLDSEELASLKFLSLDCIPQRKQEPIKDALMLFQRLQEKRMLEENNLSF LKELLFRINRLDLLTTYLNTRKEEMERELQAPGRAQISAY-------------------- ------------R------------------------------------VMLYQISEEVG RSELRSFKFLLQ-EEISKCKLDDDMNLLDIFVEMEKRVILGEGKLDILKRVCAQVNKSLL KIINDYEEFSRE------------------------------------------RTRSLE GSPEEGSN--------GEEL-------------------------CGLMTISDSPREQDS ESQTLDKVYQMKSKPRGYCLIINNYDFTKAREKVPKLHSIRDRNGTHLDAEA-LTATFEE LHFE-IQHHNDCTVEKIYKILKTYQLM-DHS--NKDCFICCILSH--GDK-------GI- IYGTDGQEAPIYELTS---QFTGLKCPSLAGKPKVFFIQ--ACQ----GDNYQKGIPV-- ET--DSEEQ-PYLEM------------------DLSSPQ-TRYIPDEADFLLGMATVN-- NCVSYRNPAEGTWYIQSLCQSLRERCP------RGDDILTILTEVNYEVSNK-------- --DDKKNMGKQMPQPTF-----TLRKKLVF-PSD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------ EFRLLLHQICEGLTGENVSMMKFLCKDAIPRSRE--LETALDFMEYFEAKGWIQEGDLGF LAEVLYRINRHDLLKLLPGVKNRRDYEENFQAQQNNFTTY-------------------- ------------R------------------------------------VVCFMLADELT EGDLKILKRLCA-GKMSKANVRRSVDVLSWLTCMEEEDLLSEGDLDFIMSILQHLDNQKP YKLFQ--------------------------------------RVRMNDNTVTLPKNQQK SNAFQPNSHLPVASGFNSLSKQEYNHTSKLEPQYVSMENHRAFNGGYNQYNNYQSEIKDT STMGILDKYPM--ERRGYCLIINNENFE-----------RQDRTGSGNDTER-LENLFKE FGFI-LDVRKDLDQREMEKVIQEYTKK-DHS--DKDCFVCVVMSH--GLS-------GC- VYGVDGLSLSTSKISK---SFRPGMCSSLTGKPKIFFFQ--ACQ----GDRTMDGHSA-- PV--DDVESD-----------------------GAASHG-RQVLPSESDFLIGHSTVP-- GYLSYRSRTDGSWFISTLVDSLEKYH-------EKEDLLSIMINVNQEMASK-------- -------PYKQMPMPIA-----TLRKKVFF-SKQ---NSNSSSNQNCNTP---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >P_pygmaeus_ENSPPYP00000014606 -----------------------------------------------------------M DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQS VPFWWRVDHILIR------------------------------------VMLYQISEEVS RSELRCFKFLLQ-EEISKCKLDDDMNLLDIFIEMEKRVILGKGKLDILKRVCAQINKSLL KIINDYEEFSR------------------------------------------------- ----------------GEEL-------------------------CGVMTISDSPREQDS ESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGA-LTTTFEE LHFE-IKPHNDCTVEQIYEILKIYQLM-DHS--NMDCFICCILSH--GDK-------GI- IYGTDGQEAPIYELTS---QFTGLKCPSLAGKPKVFFIQ--ACQ----GDNYQKGIPV-- ET--DSEGQ-PYLEM------------------DLSSPQ-TRYIPDEADFLLGMATVN-- NCVSYRNPAEGTWYIQSLCQSLKERCP------RGDDILTILTEVNYEVSNK-------- --DDKKNMGKQMPQPTF-----TLRKKLVF-PSD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_cuniculus_ENSOCUP00000006164 -------------------------------ALVESGTVGDWVTVPGEGNGYXXXXXXXX XXXXXXXXXXEQLDSELL--LKF-ELDYIPQRKQEPIQDALMLFQRLQEKRMLEENNLAF LKELLFRIHRLDLLSTLLGTSKEEMVTELQIPGRAHISAY-------------------- ------------X------------------------------------XXXXXXXXXXX XXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXX-------------------------------------------------XXXXXX XXXXXXXXXXXXX-XXXXXX-------------------------XXXXXXXXXXXXXXX XXXTSEEVYQMKSKPRGYCLIVNNYDFSIARREMPRHRNMKDRKGTEVDAEA-LSNTFTD LHFE-VVHYNDCTAKQICDILQSYQSM-DHK--DRDCFVCCILSH--GDK-------GI- IYGTDGQEACIYDLIS---YFTGSKCSSLAGKLKVFFIQ--ACQ----GDKYQQAVPA-- -I--DSEQQSYL---------------------D-SSFP-KRYVPDEADFLLGMATVN-- NCVSYRNLFEGTWYIQSLCQSLRERCP------QGEDILSILTKVNYKVSIK-------- ---EAGEKKKQMPQPTF-----TLTKRLLF-PLD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_guttata_ENSTGUP00000010625 ------------------------------------------------------------ DFRKLLFEVSEALVTEELSALKFLSLDHVPRRKLEAIHEPKAFFEVLQEKDMIGAGNLFF LKELLYRIHRIDLLSTPLGCSREEMERELQLPGRAQVSAY-------------------- ------------R------------------------------------QLLYGIAEDLT SEDVRSVKFLLQ-KQLPKNKLQENASMLQVFLEMEIKGIIKEDNMTTLKDILQRFRADIK KKIDAYEEKKKG------------------------------------------LTGSAE VSLELPVSWIDSVDHIKQST-------------------------------LGLPGEDRS LSFQLLEAYKMTSRPCGVCLILNNHNFAKAREGVLEHKHMKDRNGTDVDAAA-LRNVFSK LHFR-VEEYRDLTAEEIRETVNIFQSA-DHE--DKDCFVCCILSH--GKK-------GI- IYGVDGQEVPIRELTT---SFTAQNCSSLAGKPKVFFIQ--ACQ----GDAFHKGVAI-- ET--DSVEEDSSLER------------------D-ARFQ-LDCIPAEADFLLGMATLQ-- DYVSYRSPKEGTWYIQALCQHLEYSCP------RGEDVLTILTAVNQEVSKK-------- --TCERDAKKQMPQPSF-----TLRKRLIF-PVN-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >P_troglodytes_ENSPTRP00000021879 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY-------------------- ------------R------------------------------------VMLYQISEEVS RSELRSFKFLLQ-EEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINRSLL KIINDYEEFSKE------------------------------------------RSSSLE GSPDEFSN--------GEEL-------------------------CGVMTISDSPREQDS ESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGA-LTTTFEE LHFE-IKPHDDCTVQQIYEILKIYQLM-DHS--NMDCFICCILSH--GDK-------GI- IYGTDGQEAPIYELTS---QFTGLKCPSLAGKPKVFFIQ--ACQ----GDNYQKGIPV-- ET--DSEEQ-PYLEM------------------DLSSPQ-TRYIPDEADFLLGMATVN-- NCVSYRNPAEGTWYIQSLCQSLRERCP------RGDDILTILTEVNYEVSNK-------- --DDKKNMGKQMPQPTF-----TLRKKLVF-PSD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >H_sapiens_ENSP00000351273 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY-------------------- ------------R------------------------------------VMLYQISEEVS RSELRSFKFLLQ-EEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLL KIINDYEEFSKE------------------------------------------RSSSLE GSPDEFSN--------GEEL-------------------------CGVMTISDSPREQDS ESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGA-LTTTFEE LHFE-IKPHDDCTVEQIYEILKIYQLM-DHS--NMDCFICCILSH--GDK-------GI- IYGTDGQEAPIYELTS---QFTGLKCPSLAGKPKVFFIQ--ACQ----GDNYQKGIPV-- ET--DSEEQ-PYLEM------------------DLSSPQ-TRYIPDEADFLLGMATVN-- NCVSYRNPAEGTWYIQSLCQSLRERCP------RGDDILTILTEVNYEVSNK-------- --DDKKNMGKQMPQPTF-----TLRKKLVF-PSD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >X_tropicalis_ENSXETP00000008971 -----------------------------------------------------------M DFNSMLLSIDDGLGREDIEALKFLCRDVLRKNKLLSVRSGQELFQQLMTEDLINEDNFFL LKELLYIINHHSLL-RNLGTNKEKVQKAL--PRQGRISPY-------------------- ------------R------------------------------------QMLYQLSENIA GDDEKRVYFLLP----LQKKHKENKTFLEVLCQLERENSITEDDVELLEDIFKKVAPDLL KIIEKYKERGDK---LHQTENHLIDPSAPPEDEHELINPPLSIQVSSKDSELWDKGTESL IEHTGMIHEEAEKEDDKSGN-------------------------INHQLSDLRLNSEMT PQANKEEFYDMNHKHRGYCLIIDNSVFM----------KGNRREGSDKDAGA-LSDVFSW LGLE-VDIFENLMSEQIRDCLKRFKSR-DHS--ERDCFVCCILTH--GES-------GT- VMGSDDKEVSIREIMS---YFTAISCTSLVLKPKLFFIQ--ACQ----GKFTHPSSKV-- EA--DAIVPEE------------------------NKKY-VVNVPKDADFLLGMSTVD-- GYAAYRHTREGSWYIQALCKNLVELVP------RGEDILAILTKVNKDVSLK-------- --EGQQGILKQMPQPSY-----TLLKKLRF-PVPDVPFRPKTCQENSP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >R_norvegicus_ENSRNOP00000016613 -----------------------------------------------------------M DFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQESINDVLVLFQRLQEEGMLEEDNLSF LKELLFHISRRDLLSRVLKSSPEEMVRELQVLGKAQVSAY-------------------- ------------R------------------------------------VMLFKLSEDMD KEDLKSFKFLLI-TEIPKCKLQDNSSLLDIFVEMEKRTILAENNLVTLKSICFRVNRSLL GRIDDYERSSTE------------------------------------------RRMSTE GGEELPVS------VLDEVT-------------------------IKMQDMWDSPGEQES ESLNSDNVYQMKSKPRGYCLIFNNNNFSKAREDIPKLSNMRDRKGTNYDEEA-LSKTFKE LHFE-IVSFSDCTASQIHEVLVSYQSK-DHK--GKDCFICCILSH--GDK-------GI- VYGTDGKEASIYELTS---YFTGSKCPSLAGKPKIFFIQ--ACQ----GNNFQKAVPVPD ET--GLEQE-HVLEE------------------D-SSSY-KNYIPDEADFLLGMATVK-- NCVSYRDPTRGTWYIQSLCQSLRERCP------RGEDILSILTGVNYDVSNK-------- --DNPRNMGKQMPQPIF-----TLRKKLFF-PPN-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >C_intestinalis_ENSCINP00000011503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M ERMSDETPRKPAAGDVLKIYKSEVKRNATSESDENIDAISDSSDDFYKDDDDDGKGLVPT VLRQHMLEYYMKNERRGTFVVFNQENFD---------RMRHPRKGSGVDVEM-LVKSANK LGFEDVRVLKNQTTDEIRDHLQELSYQ-DHS--NCDCFVCVVLSH--GES-------DGV LYTKDG-DIHLKEILD---SFKASRCPSLAGKPKLFFIQ--ACR----GEKRSTPVEIEY KF--DVTDSTPP---------------------EEQTTT-VFTIPAEADFLIAHATPE-- EFCAWRNRREGSRFIKALCGCLDRYAG------DDIELLQILTVVNHHVSHG---WDGEV ---YKYEKSKQIPSITT-----QLTAQLFF-TKKSKNKICQEKPQGTIKENENANAQAND DFIAHEGQETEKEISRPIPSPRHKKT---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ETQV >B_taurus_ENSBTAP00000038128 -----------------------------------------------------------M ALTQCLYNIGEQLGSDDLAALKFLSRDHIPYRKQEPIKDALMLFQRLQEKRMLEENNLSF LKELLFRVNRLDLLLNYLYTSEEEMKRELQIPGRAQISAY-------------------- ------------R------------------------------------ILLFQISEDVN KVELKDFKFFLS-QEIAKCKLDDDMTLLDIFVEMEKRTILGEENLDTLKRICEQVNKSLL KKIYDYEELRKE------------------------------------------RRMSLE RDPYAFSNDMSQS-LPEEGY-------------------------SKMPAMSDSP-EQDS ELQTSDTVYRMTSKPRGYCLIFNNYDFSIARKQVPELHDLKDRTGTDFDADA-LDKTFRE LHFE-IVHYKDLTAKGICEVLESYQKK-DHK--NKDCFICCILTH--GNK-------GI- IYGSDGQEASIYELTS---YFTGLKCPSLIGKPKIFFIQ--ACQ----GDKYQKGVAV-- ET--DSEQMEAYLEV------------------D-SSPQ-KRYIPDEADFLLGMATVK-- NYVSYRNIWNGAWYIQSLCQNLRERCP------RGEDILTILTKVNFEVSKL-------- --DDKQRMAKQMPQPTF-----TLRKKLFF-PLN-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >C_familiaris_ENSCAFP00000017899 -----------------------------------------------------------M DFSKCLYNIGEQLDSDELASLKFLSLDYIPQKKQEPIKDPLMLFQRLQEKRMLEESNLFF LKELLFRINRLDLLMTYLDTSKEDMQQELQIPGRAQISAY-------------------- ------------R------------------------------------VMLFQISEDVS KLELKSFKFLLS-REISRCKLDDDLNLLDIFIEMEKRVILGERNLDTLKRICDQINKSLL KKITDYEELNRE------------------------------------------QTMNLQ RSLDEISNDMSQL-PIREGS-------------------------VKILPMSDSLGEQDY ESETSDKVYRMKSKPRGYCLIFNNYDFSVARREVPKLQSIKDRNGTDLDADA-LSKTFSE LHFE-IVHFKDATAKKICEVLQSYQSM-DHS--SKDCFICCILSH--GDK-------GI- IYGSDGQEAPIYELTS---YFTGSKCPSLAGKPKIFFIQ--ACQ----GDKYQKGIAV-- ET--DSEQKEAYLEM------------------D-SSYQ-KRYIPEDADFLLGMATVN-- NCVSYRNPMEGTWYIQSLCQSLRERCP------RGEDILTILTEVNFEVSNK-------- --DDRKNMGKQMPQPTF-----TLRKKLFF-PPN-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_melanogaster_FBpp0082755 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MDDTDFSLFGQKNKHKKDKADATKI------------------AHTPTSELDLKRIII SRPTNEDTYE-NCARAGIALILNHKDVK----------GQKQRVGTERDRDD-MEATLQG FGFD-VRTFDDLTFSEINDTLKEVARE-DHS--QNDCFVLAVMSH--GTE-------GK- VYAKDM-SYPVERLWN---PFLGDNCKTLKNKPKLFFIQ--ACR----GANLEKAVEF-- ----SSFAVMTRELVPEPA--------------AAVQPI-TYAIPSTADILVFYSTFD-- KFFSFRNVDDGSWFIQSLCRVLDQAAANEAATPEGVELLRLLTAVNRKVAYE---YQSNT KN-EALNQMKEMPNFMS-----TLTKTFQL-RVKPKT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_nigroviridis_ENSTNIP00000001216 ------------------------------------------------------------ --------------------------------------SAYQLFLSLCDQDHLSEERPHL LSELLSIIQRTRLLRDLDLRSS---------ATSNLISAY-------------------- ------------R------------------------------------KLLYSLSEDLT DDNLKEIKFLLT-ETLPRRKLEDNVTTLEVFLELECMDLLSKTNLGLLKSILQPVCPVLA ERIRQFEAQNSC------------QPAADWGFAVKKITDPLQVQGGSDALPSLPEENQSS SRTEASVMSSANAVGIKPGT--------------------------LMLGLSPPPVGSPN FPVQDLGTYPMTTLPRGCCLIISNYDFQ--------GSGLGMRNGTRTDEEC-LKKVFEW LGFK-VEIHRDCTGKEILSLMQELADK-SQQ--RWDCLVCCILSH--GLE-------GC- VHGVDGDQVSIKKLIE---PFLGTNCPAMAGKPKLFFIQ--ACQ----GKKQQGVVHL-- ES--DGAEHSDVDT-------------------D-AVRL-SNCIPSHADFLLGMATVP-- DYVSYRDRERGTWYIQSLCEYLVKMVP------RGFDLMSILTKVNEDVSKK-------- --NDNTGDRKQMPQPVF-----TITKRIVF-PVPSGPAPVLPHFPFVEDSP--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_musculus_ENSMUSP00000027189 -----------------------------------------------------------M DFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSF LKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPY-------------------- ------------R------------------------------------VMLFKLSEEVS ELELRSFKFLLN-NEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLL GKIEDYERSSTE------------------------------------------RRMSLE GREELPPS------VLDEMS-------------------------LKMAELCDSPREQDS ESRTSDKVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEA-LSKTFKE LHFE-IVSYDDCTANEIHEILEGYQSA-DHK--NKDCFICCILSH--GDK-------GV- VYGTDGKEASIYDLTS---YFTGSKCPSLSGKPKIFFIQ--ACQ----GSNFQKGVPD-- EA--GFEQQNHTLEV------------------D-SSSH-KNYIPDEADFLLGMATVK-- NCVSYRDPVNGTWYIQSLCQSLRERCP------QGDDILSILTGVNYDVSNK-------- --DDRRNKGKQMPQPTF-----TLRKKLFF-PP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_cuniculus_ENSOCUP00000003895 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------NSLHLLEHLEKRDDIHEDNLTYLEDLCKKVAPSLM RIIEKYKNEKXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVT--------- ------------PALASVEL-----------------------------LRAPADFLRLE TSTREANVYRMDRKHRGRCVIVNNEIFT---------TYLSDRRGTQRDAE--QKLVFQW LGFK-VHKCDNKTKEDLEALLQEEKHHPDHD--DGDCFVFCVLTH--GIF-------GA- VYSSDGVLIPIREIVS---HFTAKQCPGLAGKPKLFFIQ--ACQ----GKEIQSSAPI-- EA--DAVNPECV-----------------------PPSL-QDSIPVEADFLLGLATVP-- GYASLRHVENGSWYIQSLCNHLKALVP-------HEDILSILTAVNNDVSRQ-------- --ADKSGRMRQMPQPAF-----TLRKRLVF-PVPQEEPSF-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_gorilla_ENSGGOP00000000205 ---------------------------------------------------YILLPFEKM DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY-------------------- ------------R------------------------------------VMLYQISEEVS RSELRSFKFLLQ-EEISKCKLDDDMXLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLL KIINDYEEFSKE------------------------------------------RSSSLE GSPDEFSN--------GEEL-------------------------CGVMTISDSPREQDS ESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGA-LTTTFEE LHFE-IKPHDDCTVEQIYEILKIYQLM-DHS--NMDCFICCILSH--GDK-------GI- IYGTDGQEAPIYELTS---QFTGLKCPSLAGKPKVFFIQ--ACQ----GDNYQKGIPV-- ET--DSEEQ-PYLEM------------------DLSSPQ-TRYIPDEADFLLGMATVN-- NCVSYRNPAEGTWYIQSLCQSLRERCP------RGDDILTILTEVNYEVSNK-------- --DDKKNMG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_guttata_ENSTGUP00000017449 ------------------------------------------------------------ --------------------------------------------MEERQRRALRRGRARL VAALRVEPLWEPLEQRGLFT-------------------R-------------------- ------------P------------------------------------MLEELQS--AG SRGEQARQLIIDLETRGKQAFPAFLSILRDTGQGHLAEMLMQECESRPVPPQLPDLRPVE L-------------------------------------------------------ELQE ANQRCAVVLQTAARDVAAGI-------------------------------PLTVGKSPE VMSFIILDYEMKADPCGHCLILNNVNFC-------RDSGLSTREGSDIDCEK-LERRFKA LCFT-VLTRRDLKAQEMVLELLKLSRQ-DHS--ALDCCIVVILSH--GCQTSHIQFPGG- VYGTDGKPIPIEKIVN---YFNGSSCPSLRGKPKLFFIQ--ACG----GEQRDQGFVV-- DC--DSPKEEALGDSLESDAIPFRVPSDNV---D-EPDA-IASLPTPSDILVSYSTFP-- GFVSWREKSSGSWYVETLDSVLEQYA-------HSEDLLSMLVRVAHAVSAR-------- ------GRYKQIPGCFN-----FLRKKFFF-VCR-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_anatinus_ENSOANP00000006351 -----------------------------------------------------------M DFHRLLFSIGEELAADDLEALKFLCLDLIPRKKQENIQDALGLFRLLQEKGMLEEGKLFF LKELLFRIHRIDLLTSHLRTSQEDVARELEEPGRAQVSAYS------------------- ------------R------------------------------------VLLFTLSDNVT REELKSITFFLS-NDLPRSRLDNKQTLMGIFIEMEKKGILGESNLDMLKKICDKIDKTLL GKIDHYEERRAD------------------------------------------CTLHSS EHLTVLDRDMYIIPIIYDEI-------------------------ILLPTESSFRGHSGG EAEQNGDFYKMNSNPRGYCLIINNYNFQQARAEVPKLKKMKNRDGTDKDAEA-LSQIFKA LAFS-PVVFEDQTAEQILETLQSYQRM-DHS--AQDCFVCCILSH--GDR-------GV- VYGTDGQQASIRSLTS---YFTGSRCPTLAGKPKLFFIQ--ACQ----GDAYHLAVAL-- ET--DNGTDKGTAAASPAEP-------------D-AVFH-ERCIPDEADFLLGMATVS-- NCVSYRIPSKGTWYIQSLCHHLRNLCP------LGADILTILTKVNFEVSQK-------- --IDLTNRGKQMPQPMF-----TLRKKLVL-PLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >H_sapiens_ENSP00000286186 ------------------------------------------MKSQGQHWYSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF LAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLF-------------------- ------------R------------------------------------NLLYELSEGID SENLKDMIFLLK-DSLPKTEM----TSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLL RNIEKYKREKAI---QIVTPPVDKEAES-YQGEEELVSQTDVKTFLEALPQ-ESW-QNKH AGSNGNRATNGAPSLVSRGM-----------------------------QGASANTLNSE TSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKDRQGTHKDAEI-LSHVFQW LGFT-VHIHNNVTKVEMEMVLQKQKCNPAHA--DGDCFVFCILTH--GRF-------GA- VYSSDEALIPIREIMS---HFTALQCPRLAEKPKLFFIQ--ACQ----GEEIQPSVSI-- EA--DALNPEQA-----------------------PTSL-QDSIPAEADFLLGLATVP-- GYVSFRHVEEGSWYIQSLCNHLKKLVP------RHEDILSILTAVNDDVSRR-------- --VDKQGTKKQMPQPAF-----TLRKKLVF-PVPLDALSL-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_gallus_ENSGALP00000013591 -----------------------------------------------------------M EFSQLLFVISEALDRTELASLKFLSLEHVTVRKREDIEEPKAFFQALQEKGMIEVGDLFF LKELLYRINRIDLLASYLGSSREEMERELQVPGRARVSPF-------------------- ------------R------------------------------------YLLFQLSENIT KDDMKCFKFLLG-KELPKCKLSPETTMPDVFIEMEKKGILKEDNLTVLKTICGKVDKSLL KKIEDYE-----------------------------------------------LNLLGE GEMLVTEGQRSSTGAPEDSA-------------------------IWLASSVAPDSLGNC DQSSQLEVYKMTSRPRGVCLILNNHNFAKAREAVPELRRMKDRNGTHVDADA-LRKVFSN LHFT-VAEYKDCTAEEIRNIVNNYRCM-DHN--NKDCFVCCILSH--GKK-------GI- IYGVDGQEVPIQELTT---SFTGQNCQSLAGKPKVFFVQ--ACQ----GDAYQKGVTI-- ET--DSGEQDYSLET------------------D-ARFQ-LDCIPSEADFLLGMATLQ-- DYVSYRSPSQGTWYIQSLCQHLESSCP------RGEDILTILTAVNQEVSSK-------- --IDKQNAGKQMPQPSF-----TLRKKLIF-PVN-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >C_intestinalis_ENSCINP00000025905 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ TDAGGFDPGSEGTITEIGDT-------------------------DQNETIKRGFISLDE LGENFDFCYNMQHKKRGLFVVFNQMKFD-------KHLKLSERTGSDKDAAA-LLKTAEL LGFE-TEEYLDLERKQIRRKLYELSEM-DHG--DHDCFACAILTH--GGK-------DNI LYSHDD-EMKLKDFTT---PFEADKCRSLASKPKLFFVQ--VA----------------- ----------------------------------------SFTLTFVNAFLVCFELRHTY YYYAWRSSDKGSIFIQTLCSVFERYS-------DEMDIMKILTRVNRVVAFN---FESWT QR-PDMNHMKQIPSITS-----QLTAELFI-K---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_musculus_ENSMUSP00000030747 ------------------------------------------------------------ --------------------------------------------MDEADRQLLRRCRVRL VSELQVAELWDALLSRELFT-------------------R-------------------- ------------D------------------------------------MIEDIQQAGSG SRRDQARQLVTDLETRGRQALPLFISCLEDTGQGTLASLLQSGRQAAKQDPE--AVKPLD HLVPVVL---------------GPMGLTAKEQRV-VKLDPSQPAVGNLTPVVLGPEELWP ARLKPEVLRPETPRPVDIGS-----------------------------GGAHDVCVPGK IRGHADMAYTLDSDPCGHCLIINNVNFC-------PSSGLGTRTGSNLDRDK-LEHRFRW LRFM-VEVKNDLTAKKMVTALMEMAHR-NHR--ALDCFVVVILSH--GCQASHLQFPGA- VYGTDGCSVSIEKIVN---IFNGSGCPSLGGKPKLFFIQ--ACG----GEQKDHGFEV-- AC--TSSQGRTLDSDSEPDAVPYQEGPRPL---D-QLDA-VSSLPTPSDILVSYSTFP-- GFVSWRDKKSGSWYIETLDGILEQWA-------RSEDLQSLLLRVANAVSAK-------- ------GTYKQIPGCFN-----FLRKKLFF-KTS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >R_norvegicus_ENSRNOP00000017972 ------------------------------------------------------------ --------------------------------------------MEEADRQLLRRCRVRL VRELQVAELWDALLSRELFT-------------------R-------------------- ------------D------------------------------------MIEDIQRAGSG SRRDQARQLVIDLETRGRQALPRFISCLEDTGQGSLASFLQSSGQAAKQDPE--AVTPLD HLVPVVL---------------GPMGLKSKEQKV-VKLDPSQPALGNLTPVVLGPEELWP TRLRPEVLTPETPRPVDIGS-----------------------------GRAHDVCTPGK IERHADMAYTLDSDPCGHCLIINNVNFC-------PSSGLSTRIGSHVDCEK-LQHRFCW LRFM-VEVKNDLTAKKMVTALMEMAHR-DHR--ALDCFVVVILSH--GCQASHLQFPGA- VYGTDGCSVSIERIVN---IFNGTGCPSLGGKPKLFFIQ--ACG----GEQKDHGFEV-- AF--TSSQDKAFDSDSEPDAVPYQEGPRTL---D-QLDA-VSSLPTPSDILVSYSTFP-- GFVSWRDKKSGSWYIETLDGVLEQWA-------RSEDLQSLLLRVANAVSEK-------- ------GVYKQIPGCFN-----FLRKKLFF-KLH-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >E_caballus_ENSECAP00000004055 -----------------------------------------------------------M NFNSCLYNIGEQLDSDELASLKFLSLDHIPQRKQEPIQDALMLFQRLQEKRLLEESNLSF LKELLFRINRLDLLTTELDTSKEEMERELQSPGRAQISAY-------------------- ------------R------------------------------------VMLFQISEDVN KLELKSFKFLLS-RELPKCRLDDDMILLDIFIEMEKRVMLGERNLDTLKKICEQVNKSLL KKINDYEELSRE------------------------------------------GRISLE RSPDEFSNASLKC-LQREGS-------------------------LAGQAMSDSPGQQNS ESQTSDKVYRMESKPRGYCLIFNNHDFSAARRDVPKLQNIKDRNGTDLDAEA-LSMTFTE LHFE-VVPYKNSTAKDICDALREYQEM-DHK--KKDCFICCILSH--GDK-------GI- IYGCDGQEASIYELTS---YFTGSNCPSLAGKPKIFFIQ--ACQ----GDNYQKGIAV-- ET--DSELTDAYLEM------------------D-SSFQ-KRCIPDEADFLLGMATVN-- NCVSYRNPLEGTWYIQSLCQSLRERCP------RGEDILTILTNVNFEVSSK-------- --DDKKNMGKQMPQPTF-----TLRKRLVF-PLN-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_aculeatus_ENSGACP00000005791 -----------------------------------------------------------M HFQKLLFDIGKALSGEEVKALAFLCTD-ILGRNLSSVESASGLFSRLRDQGFLSAEQPHL LTELLIIIQRVRLT----------RDVDLPAEPSSLISPY-------------------- ------------R------------------------------------KMLYNLSEELT ADDLKDMKFLLH-SYLPRRKLEENVSTLEIWLEMEHKDLMNEHNLHLLEILISKVCPMLK DKINQLKAQQET--------------------PTSPATQESGRQGSLSAPNAPNQVPQSL GAEGTGLFEMQDSPSGFNGGGDCAALSLGLSGHLKIEVVETMPPPKNMSCSEPPTSQPSD TNTEVLGTYPMTSAKRGICLIVNNFDFT-------KFKNYQNREGTMKDEER-LHKVFAW LGFE-VEVKHDCEGEQMLTALRELASR-NHG--QADCLVCCVLSH--GDE-------GC- VYGVDGHTVAIKELKE---PFNGLNCASLAGKPKLFFIQ--ACQ----GTGEQKAVNV-- VP--DGPEDSAVCS-------------------D-AFKA-SDAIPSEADFLLGMSTVP-- SFVSYRHRKNGSWFIESLCQNLVQMVP------KL------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_anatinus_ENSOANP00000015596 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AG TRRDQARQLVTDLETRGRRALSVFISCLRETDQHALAALLSEGCQAPQVTPV--DIRPVE IIRPGGQ--------------------GDVCKYSKIHPKCYSPPLPFQSTSPLRGKEQWT GSVKPFVPVPSTTKR------------------------------------EQEATRPGE KQGMAIKVYSLKSEPCGHCLIINNVDFS-------LGSGLSTRTGSDVDCEK-MKRRFRL LHFE-VAVERNLTAEEMVKALNKLAKK-DHS--ALDCCVVVILSH--GYQASHIQFPGG- IHGTDGESISVETIVN---YFNGSRCPSLGGKPKLFFIQ--ACG----GEKKDPGFEV-- NL--DSPEDHPTGSDPESDAAPFQAAPEDY---D-EPDA-VASLPTPSDILVSYSTFP-- GFVSWRDTQSGSWYIETLDSVLDQWA-------HTEDLLTLLLRVSNGVSSK-------- ------GKYKQIPGCFN-----FLRKRLFF-NTK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_domestica_ENSMODP00000036247 -----------------------------------------------------------M DFHTFLYGIAEEIDSADLASLKFLCLDQIPLKKQQHIKDALVLFQTLEERGLLEEDNLFF LKELLFRINRIDLLNEPLNTKGPEMERELQVPNKARISPY-------------------- ------------RLHLHTTIWPFRDNWTCRITLSVSFTSRTKQLLSVMVILLFNLSEGVG PSELKSIKFMLS-SKIPKCKIEDDMTLMDLFIEMEKRGILGEGNLDALKIVCDQIDKSLL KKIQEYEISKGR------------------------------------------------ -------------------------------------------NNLFLIYQNTQPQEVYD SAGEKGNVYKMSSRPRGYCLIINNFDFKISRKERPENHYLTDRRGTNKDEEA-LKNIFKE LHFD-IQSFQDLTAEGIQQVLKTFKDN-NHE--SKDCFVCCLLSH--GNK-------GT- IYGIDGKEVPIRDLTS---YFSGSNCPSLAGKPKVFFIQ--ACQ----GKATQYGISL-- DT--DSEQQRESLEA------------------D-KSFQ-SECIPNEADFLLGMATVE-- NYVSYRDSARGTWYIQSLCKNLKEGCL------RGNDILTILTEVNSEVSQK-------- --TDPKNNGKQMPQPKI-----TLRKKLVF-PIS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >E_caballus_ENSECAP00000021726 ------------------------------------------MTSQGQNLNSSSDDNCTM DFRQKLLFIDSHLGDQDVERLRFLCRDCVSHKKLEKSSSALEIFNHLLAEDLLREEDSFF LAELLYIIKQKSLL-CHLCYTKEQVESLL--PARRRVSLF-------------------- ------------R------------------------------------NLLYELSEGMD SDNLNSMMFLLK-DSIPKTQM----TSLSLLAHLEKQARIDEDNLTLLEMLCKNVVPNLM RKIEKYKREKAA---QVVTAPVDKETESLHHGEEELFSRSDIKKFSRALPQ-----PWEH THAGLGSLPLG-NSRVSKGW-----------------------------SSALASGIGSI SSSKETPLYRMDRTHRGHCVVVNNHTFT----------SLADRPGTDKDAEC-LKSVFQW LGFS-VHRYDNVTKEGLEKVLQEYRNHPGHA--SGDCFVFCVLTH--GKF-------GA- VYSSDGILIPIREIMS---HFTAQRCPALAHKPKLFFIQ--ACQ----GEEVQPSVSI-- EA--DAVNPENV-----------------------TPSL-EDSVPVEADFLLGLATVP-- GYVSFRHVKEGSWYIQSLYNNLKDLVP------RREDILSILTAVNDDVSRQ-------- --VDIYGKKKQMPQPAF-----TLRKKLVF-PVP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >E_caballus_ENSECAP00000015102 ------------------------------------------------------------ --------------------------------------------MNEADRQLLRRSRLRL VRELQVDSLWDALLTRELFT-------------------P-------------------- ------------D------------------------------------MIEDIQR--SG SRRDQARQLIIDLETRGSQALLLFISCLEDTGQDTLASFLRTSSQAAKQNPE--AIRPSD -LPPVVL---------------GPVGLKPEELTA-VKQDPSKLTPGKLTPVVLGPEELWL AKLRPEVLRPEVPRPVDIGS-----------------------------GGFSDVRAQDR LRGNADLAYVLNADPCGHCLIINNVNFY-------LASGLGRRVGSDIDCEK-LRQRFSL LHFM-VEVKGDLTAKQMLRALGELARR-DHG--ALDCCVVVILSH--GCQASHLQFPGA- VYGTDGCPVSIESIVN---IFNGTGCPSLGGKPKLFFIQ--ACG----GEQKDPGCKV-- DS--TSPEDRTPGSDSEPDAVPFQEGPGTF---D-QPDA-VSSLPTPSDIFVSYSTFP-- GFVSWRDPKSGSWYVETLDGVFEQWA-------HSEDLQTLLLRVAHAVSEK-------- ------GVYKQIPGCFN-----FLRKKFFF-KTY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >C_intestinalis_ENSCINP00000028692 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MS ENKEKDIRESWSQENLPEAGHEIKTEL--------------------------------- -------------------------------------------------DLNLDFSRSDA TDAGGFDPGSEGTITEIGDT-------------------------DQNETIKRGFISLDE LGENFDFCYNMQHKKRGLFVVFNQMKFD-------KHLKLSERTGSDKDAAA-LLKTAEL LGFE-TEEYLDLERKQIRRKLYELSEM-DHG--DHDCFACAILTH--GGK-------DNI LYSHDD-EMKLKDFTT---PFEADKCRSLASKPKLFFVQ--ACR----GDLLDRGAKVIH LK--QSTGDVLDR--------------------NPSKVE-SYTIPVQADFLISQATAP-- DYYAWRSSDKGSIFIQTLCSVFERYS-------D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >C_familiaris_ENSCAFP00000017933 ------------------------------------------MTSQAQSLTFRSDDNCQS SFRGKLLTIDSKLEIQDVEGLKFLCRDFVSHKKLEKSNSASDIFDHLLAEELLSEEDPFF LAELLYIIKQNSLL-RYLNQSKEQVESLL--PTRRRVSLF-------------------- ------------R------------------------------------NLLYELSESIG SENLKDMIFLQR-DSMPKTQL----TPLSFLAYLEKQALIDEDNLGLLEDLCRKVVPNLI RKIERYKREKAS---EVVTPPVDTETESLHQKEEELFSPSDINQFHGALSKQTSWNPLKH RAKQGNIISDG-ATLVSVEM-----------------------------LEASTGPLTSE TSTKEANVYRMDRKHRGHCVIVNNHTFA----------KMPDRPGTDKDAEC-LSRVFQW LGFS-VHVYKNVTKGHLDEVLQEFKCHPDHV--DGDCFVFCVLTH--GKF-------GA- VYSSDGTLVPIREIMS---HFTAQKCPGLAHKPKLFFIQ--ACQ----GKGIQTPVSI-- EA--DAVNPEHV-----------------------SPSL-KDSIPDAADFLLGLATVP-- GYVSFRHVEKGSWYIQSLCNRLKSLVP------RHEDILSILTAVNNDVSQQ-------- --ADKQGTMKQMPQPAY-----TLRKKLVF-PVPQKELLL-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_carolinensis_ENSACAP00000001629 ------------------------------------------------------------ -FRQILLAIDENLGKEDVDAMKFLCSDFISTKHLEGVETAQDIFQLLINRNLLSKEDTFI VAELLYRIKCHFLL-QKIGYTQQKVEHNL--FHIRNVSEY-------------------- ------------R------------------------------------QMLYEISEGFT EENVKTAMFLLR-EHLPKKQS----IAVKLLTSLEKQDLLAEDKLAILEKICNKVSPELR NKVDKFKERSVF------------KAFVFSLCYENLYPSNFLAVFLL------------- ------------------------------------------------------------ -ILQASTCYKMDGLNRGSCLIFNNVHFE---------GGLSQRRGSQKDAEE-LESVFRW LGLD-VIKYNDTTSIEMENHLKQWQSFENWK--DMDCLVCCILSH--GES-------GK- IYGTDGNLIPIRTIMS---YFTAKQCPQLAKKPKLFFIQ--ACQ----GEKTQQPVYL-- ET--DDEYGSFP-----------------------LQQM-ISSIPEEADFLLGMATVD-- GYLSFRHVHQGTWYIQALCDKLRTLVP------RGEDILSILTEVNADVSRR-------- --ADAQGQKKQMPQPAY-----TLRKKLIF-PIP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_rubripes_ENSTRUP00000047737 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MLQLRTLLDRGREGKRAVIVSVEQYY-------PGVGLQRRLGATKDARK-LHSTLFK MGFK-VELHLDLSSDDIYELFHD--ES-RRP--VDDCFLAVLSSH--GEE-------GC- VFGSDGNPVQLSRIFA---LFDS---KCMEKKTKMFLIQ--ACR----GGALDDGVEV-- ----DSATDA-----------------------STASIF-QQYLSIPMDTVVMYATAP-- GYAAFNNPM-GSPFLGEFCDLLLEDGQ------RDLELTRLMTRVSYRLAYN---FQAKG ---KVLAGKKQMPCLLT-----RMTREAFPFAQPGKAGVAPGLSATSLVHDAANMRARAP SIS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >B_taurus_ENSBTAP00000003205 ------------------------------------------------------------ --------------------------------------------MNEADRLLLRRYRVRL VGELQVASLWDALLSRELFT-------------------P-------------------- ------------D------------------------------------MIEDIQRAGSG SRRDQARQLILDLETRGSQALPLFISCLEDTGQDTLASLLKTSRQAAKQ----------- ----------------------------------------SKPSQGKLAPVVLGPEELWP AKLRPEVLRPEVPRAVDAGS-----------------------------GGFTDVCPQDR AKGNADLAYVLNADPCGHCLIINNVNFC-------RESGLRARTGSNIDCER-MRQRFHL LQFV-VEVKCDLTAKQMVQALMQLARQ-DHS--ALDCCVVVILSH--GCQASHLQFPGA- VYGTDGCPVSVERIVN---TFNGTGCPSLRGKPKLFFIQ--ACG----GEQKDHGFEV-- ES--TSPEDKTPSSDPEADATPFQEGPRSI---D-EPDA-VSSLPTPSDILVSYSTFP-- GFVSWRDPKSGSWYIETLDSIFEQWA-------HCEDLQTLLLRVANAVSVK-------- ------GIYKQMPGCFN-----FLRKKLFF-KT--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_gambiae_AGAP004922-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CNLMDDLPPEPTPNNEFYDGNIPE--------------- ------------------------------------------------------------ ----------------------------------------MLMTH--GDD-------DV- LYAYDG-PYSVDKLWE---SFMGNACTTLLGKPKLFFVQ--ACR----GSTFDKGVKLGC ----RDLDS------------------------DHFSSH-KYVIPTTADLLVMYSSYK-- GHVSWRSPRGGSWFIQALCVELETNW-------KHMELLQLLTGVSRRVAYD---YQSNV PCKGRMDAMKQMPSIVS-----MLTKLVYF-PLKLGS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_gambiae_AGAP012945-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-DHK--NSDCLLVVIMTH--GDD-------DV- LHAKDG-TFNVDRLWE---NFIGDSCPSLLGKPKLFFIQ--ACR----GSSFDTGVHF-S QCMTQVAKT---------------------------SSI-QYAIPSMADLLVMYSTYK-- GHYSWRNPSTGSWFIRALCDELREHG-------NSKELLQLLTSVSRRVAYE---FQSNV PN---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >P_pygmaeus_ENSPPYP00000014602 ------------------------------------------MKSQGQHWCSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCVGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF LAELLYIIRQKKLL-QHLSYTKEEVEGLL--PTRQRVSLF-------------------- ------------R------------------------------------NLLYELSEGID SENLKDMIFLLK-DSLPKTEM----TSLSFPAFLEKQGKIDEDNLTCLEDL-KTVVPKLL RNIEKYKREKAV---QIVTPPIDKEAES-YQGEEELVSQTDVKTFLEALPQEESW-QNKH AGSNGNRATNGAPSLVSRGM-----------------------------QGASANTLNSE TGTKGRKGYRMNRNHRGLC-LLNNHSFT----------SLKDRRGTHKDAEI-LSHVFQW LGFT-VHIHNNVTKGEMEEVLQEQKCNPAHA--DGDCFVFCILTH--GKF-------GA- VYSSDEALIPIREIMS---HFTALQCPRLAEKPKLFFIQ--ACQ----GEEIQPSVSI-- EA--DALNPEQP-----------------------PTSL-QDSIPAEADFLLGLATVP-- GYVSFRHVEEGSWYIQSLCNHLKKLVP------RHEDILSILTAVNDDVSRR-------- --VDKQGTKKQMPQPAF-----TLRKKLVF-PVPLDALSL-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >P_pygmaeus_ENSPPYP00000002138 ------------------------------------------------------------ --------------------------------------------MDEADRRLLWRCRLRL VEELQVDQLWDALLSRELFR-------------------P-------------------- ------------H------------------------------------MIEDIQRAGSG SRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKL----------- ----------------------------------------SKPTLENLTPVVLRPEIVRP EIRKPEVLRPETPRPVDIGS-----------------------------GGFGDVGALES MRGNADLAYILSMDPCGHCLIINNVNFC-------RESGLRTRTGSNIDSEK-LRRRFSS LHFM-VEVKGDLTAKEMVLALLELAQQ-DHG--ALDCCVVVILSH--GCQASHLQFPGA- VYGTDGCPVSVEKIVN---IFNGTSCPSLGGKPKLFFIQ--ACG----GEQKDHGFEV-- AS--TSPEDESPGSNPEPDATPFQEGLRTF---D-QLDA-ISSLPTPSDIFVSYSTFP-- GFVSWRDPKSGSWYVETLDDIFEQWA-------HSEDLQSLLLRVANAVSVK-------- ------GIYKQMPGCFN-----FLRKKLFF-KTS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_nigroviridis_ENSTNIP00000016604 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MLQLEKLLNPGRQGRRAVIVSVGEFY-------PQVGLQRRPGASRDAKR-LHKTLMK MGFK-VDIHQDLSSGEIYELFEQ-AES-RRP--VEDCFLAVLSSH--GEE-------GC- VYGWDGEPVQLSHIFA---YFDN---KCMEKKTKVFLIQ--ACR----GDALDDGVEV-- ----DAAADADADA-------------------SAACVF-QQCLSVPLDTVVMYATAP-- GYAAFMNAA-GSPFFKAFCDLLLEDGQ------RDLELTRLLTRVSHRLAYT---FQARG ---PALDGKKEMPWLLT-----RMTREAFPFAEPGKTSGASGLSATSLVHDATSMRARTP SIS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_mulatta_ENSMMUP00000037898 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MRIPTKWF--------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------Y LFFKRAPTYRMDRNHRGLCVIVNNHSFI----------SLRDRRGTHKDAEI-LKGVFQW LGFT-VHIYNNVTKGEMEEVLQKEKCNPAHA--DGDCFVFCILTH--GED-------GA- VYSSDEALIPIREIMS---HFTALQCPGLAEKPKLFFIQ--ACQ----GEKIQLSKSI-- EA--DALNPEQA-----------------------PTSL-QDSIPVEADFLLGLATVP-- GYVSFRHVEEGSWYIQSLCNHL-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_gallus_ENSGALP00000013506 -----------------------------------------LKSFKPHWISSNMEDDDSL QFRQLLLLIDEGLGAEDVAALKFLCTDLIPFRKLESVQSAMDIFQLLIDEDYLNEEDTFL LAELLYRIKYHSLL-SKLGYTKEKVQECL--HEKGKVSPY-------------------- ------------R------------------------------------QMLYELSENIT NDMLQEIVFLLR-NHLPKRRR--TISALELLILLEKQCLLTENNVQILEEVFRNVSPDLL ETVKCYRMAKVALPHQGNTLPIK-ESSPSYTVHVRLFNSPQGGSFILVLNESYCESLRNK KYSVTGASAACHAISMPSTG----------------------------VQNALANTTVCY SSFLQVSSYKMDGPRRGICLVINNVKFD---------GVLQERKGSYKDACE-LERVFTW LGLD-VRTYTDQTSDQIKELMQAWQRSEDHK--NRDCFVCCILSH--GES-------GA- VYGKDGKLVSIRTIMT---YFTAKQCPQLTEKPKLFFVQ--ACQ----GKEVQRPVYV-- ET--DARVPDFSSVPQ-------------------STSP-SESIPEEADFLLGMATID-- GYASFRHVQEGTWYIQALCSKLQLLVPS-----RGEDILSILTEVNEDVSKR-------- --VDRYGTRKQMPQPAY-----TLRRKLIF-PIPRDPPPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_rerio_ENSDARP00000071183 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------RALIVSVENFY-------PGAYLCRRIGVKRDSRR-LYKILSE LGFS-VDIRLDIEAEEIYQAFKAASES-EQT--VKECFVGIISSH--GEE-------GV- VFGCDGRAVNLAEIYS---CFRS---PIMKDKSKLFLIQ--ACR----GGDLDGGVELET ----DSSSSEE------------------------QDIL-SELLSIPIDTAVTYATSP-- GYAAFMHPL-GSVLIQTLCDLLESDGG------PDLEITKLLTRLNHQVAYN---FQARG ---KILGGKKQMPCFVT-----RFTREVFPFR---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_rerio_ENSDARP00000075318 ------------------------------------------------------------ ------------------MADQLLENLRPDLIKGLSERVINGLLDDLQQKKVFGEEEIED IQHR-------------------------------------------------------- ----------------------------------------------------------MK TRADQARHVIDDVKRKGVKASEIMLASLKTRDPHLYDTLGIERLLVPVPET--------- ------------------------------------------------------------ ---------------------------------------------ELTPSQLSETTGCST DKTNTMNEYEMKSNPRGLCLIFNNENFK---------DPDMKRHGSQMDTAS-LKDLFEW LGFS-VEIKQDQTVSAMKRTLKEYSE--DRK--HGDCFVCCVLSH--GNE-------SG- VLGSDEKICPVDDITS---PFNGANCSSLAGKPKVFFIQ--ACR----GHEIQSKVMVA- ----DGSGGSRT---------------------QKPGRV-SVSIPKDSDFLIARSTVE-- GYVSIRDRTSGTWFIQSLCENLKEGSK------RGHDILMILTKVNNDVSRK---EGSLK VK-NEIVDAKVTPQPIF-----TLRKLLIFRPLKKTGRFS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_aculeatus_ENSGACP00000023872 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------TNRAVLVSVEQFD-------PGVVLRRRPGASKDAKK-LHRTLSQ LGFK-VEIHSDLSAEEIYQLFLQ--ES-MRP--VKNCFLAVLSSH--GDQ-------GC- IFGADGKAVKLSRIFS---YFDN---ECMKKKAKVFLIQ--ACR----GTGLDDGVEV-- ----DSANDTR------------------------ECSV-SQYLSVPMDTAVMYATPP-- GYGAFMHPL-GSVFLQTFCTLLRQGDN------RNLELTRLMTRLSHMVAYS---FQARG ---GALGGKKEMPCFLT-----RLTREVFPFAEP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_aculeatus_ENSGACP00000002479 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------TNRAVLVSVEQFD-------PGVVLRRRPGASKDAKK-LHRTLSQ LGFK-VEIHSDLSAEEIYQLFLQ--ES-MRP--VKNCFLAVLSSH--GDQ-------GC- IFGADGKAVKLSRIFS---YFDN---ECMKKKAKVFLIQ--ACR----GTGLDDGVEV-- ----DSANDTR------------------------ECSV-SQYLSVPMDTAVMYATPP-- GYGAFMHPL-GSVFLQTFCTLLRQGDN------RNLELTRLMTRLSHMVAYS---FQARG ---GALGGKKEMPCFLT-----RLTREVFPFAESGVDPSAMSPCQRGLLS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_aegypti_AAEL003439-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MDTADELDVLGFGNKTNESSTSNENRPL SRPTCDEYYDMSNKRRGIALVFCHMNFA----------VMAKRNGTDKDRDD-ICSTLSG LDFD-VRVFNDLRRKELLRTLKNVSRE-DHS--ENDCLVVVVMSH--GDQ-------GV- LYASDK-KYYVDSLWE---KFTGNACPSLIGKPKLFFVQ--ASRERQPGKKGEGGREEES QASVDVVDS------------------------PNDSSA-LYFIPTMADFLVMYSTYD-- GYYSGKDPLQRSCLIQSLCMELDENG-------RERDLLALLTGVSRRALYT---CESSV PHNEKDNALKPIPCVVS-----MLTKTFFF-TKKT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_aculeatus_ENSGACP00000016983 ------------------------------------------------------------ ------------------MSARGKVRSQKTAIHEALCADYSLILNKVFEKGLITPREYRN LKSI-------------------------------------------------------- ---------------------------------------------------------NKE SVEGHVIELVDKLLDKGEDTCEAFLSLLQTDDDI-------------------------- ------------------------------------------------------------ -----------------------VKTYPALRTLQLDDRGTLHAPVQDTSVGHSDVRPPPS KKLKKDERYELNSQPSGLCVIINNKNFS------------KPRRGSDKDAES-LGEVFTW LGFR-ALMCKDQTKDQMERALNKFTAL-QEAPRHGDALICCILSH--GRK-------GV- VLGIDDQPLSIKQIIG---TFLPPANTTLTGKPKVFLIQ--ACQ----GGQAQHGVFE-- EL-------------------------------QADDSP-SPTIPKEADVLVAVATVE-- DYLAFRHITDGSWFIQSVCEQLKDGCP------RGEDITTILQRVNWEVGKK-------- EGCSAPGAGKQMPEVRF-----TLRKKLVLSPHPNCFVAK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_gallus_ENSGALP00000002083 ------------------------------------------------------------ --------------------------------------------MEEAQRSALRRGRVRL VEGLRPEVLWGPLQARGVFT-------------------S-------------------- ------------A------------------------------------MVEDMQS--TG TRREQARQLVIDLETRGKQAFPIFLSILRDTGHGDLADMLDEGCGSPMSPPV--DLRPVQ LELPGER-----------------------------------------------RDKSVS TAERLSIPVQPESERFRMPP-------------------------------APAQACPTG LAGECSEVYQLRADPCGHCLIFNNVSFS-------RDSDLSTRAGSDIDCEK-LEKRFRS LCFH-VRTLRNLKAQEIDVELRKLARL-DHS--ALDCCLVVILSH--GCQTSHIQFPGG- IYGTDGKIIPIERIVN---YFNGSQCPSLRGKPKLFFIQ--ACG----GEQKDQGFEV-- DC--ESPQDETCRRSIESDAIPFQAPSGNE---D-EPDA-VASLPTPGDILVSYSTFP-- GFVSWRDKVSGSWYVETLDSVLEHYA-------RSEDLLTMLLRVSDIVSTK-------- ------GRYKQIPGCFN-----FLRKKFFF-LCK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_gallus_ENSGALP00000013571 ---------------------------------------------------------MSS DFRKLLFDISEALATEELAALKFLSLEHVPVRKQEDTEEPKAFFEVLKEKGMIEVEDLFF LKELLYRINRIDLLASHLGSSREEMERELQVPGKAKVSAY-------------------- ------------R------------------------------------QLLYGIAEDLT PDDVRSIKFLLQ-EKLPKNKLQDNASMLKVLVEMERNGIIKEDDLTMLKSILKAFRADLK KKIDNYEEKTKG--------------------------------WPWKSSCFPNKTQALS ISENLAVSSLIDNKESQESQ----------------------------SEWYSAGIFPPH VQILLVESYKMENNPHGYCVILNNYRFK---------NPNETRKGTVEDGKA-LKRVFKW LQFD-TIEYMDLEAKQIFAKVNEYSKK-DHS--NMDCFVCFILSH--GEK-------GK- IKGVDNELVNIKDLLS---CFSGSNCPSLAGKPKLFFIQ--ACQ----GSVGHPAVTV-- KE--DCSGHLET-----------------------DAIP-ALSIPDQADVLVGMATVE-- DFECYRSIETGSVYIQCLCDKMELLCP------LRKDLITILTEVNKEVGRR-------- ----VLNGWKQMPKITS-----TLRKQFIF-QIPQCQ----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >C_elegans_C48D1.2 ------------------------------------------------------------ -------------------------------------------MMRQDRRSLLERNIMMF SSHLKVDEILEVLIAKQVLNSDNGDMINS------------------------------- ----------------------------------------------------------CG TVREKRREIVKAVQRRGDVAFDAFYDALRSTGHEGLAEVLEPLARSVDSNAVEFECPMSP ASHRRSRALSPAGYTSPTRVHRDSVSSVSSFTSYQDIYSRARSRSRSRALHSSDRHNYSS PPVNAFPSQPSSANSSFTGC--SSLGYSSSRNRSFSKASGPTQYIFHEEDMNFVDAPTIS RVFDEKTMYRNFSSPRGMCLIINNEHFE----------QMPTRNGTKADKDN-LTNLFRC MGYT-VICKDNLTGRGMLLTIRDFAKH--ES--HGDSAILVILSH--GEE-------NV- IIGVDDIPISTHEIYD---LLNAANAPRLANKPKIVFVQ--ACR----GERRDNGFPVL- ----DSVDGVPAFLRRGWDNRDGPLFNFLGCVRPQVQQV-WRKKPSQADILIAYATTA-- QYVSWRNSARGSWFIQAVCEVFSTHA-------KDMDVVELLTEVNKKVACG---FQTS- ---QGSNILKQMPEMTS-----RLLKKFYFWPEARNSAV--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_anatinus_ENSOANP00000005531 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------YRMNRAHRGYCIIFNNYTFK---------GKLNSRKGTQKDVAE-LERVFRW LGLD-VETFNDKSRQEMVATLEECSRRPDHD--VRDCLVCCVLSH--GES-------GA- VYSADEELIPIRQIMS---YFTAKDCPSLAHKPKLFFIQ--ACQ----GKDIQEAVQI-- EP--DARNPDLDPQPEPPP--------------APRESP-KDSIPAEVDFLLGMATVD-- GYASFRHVNQGTWYIQALCRQLALLVP------RREDILSILTAVNDDVSQR-------- --ADHLGKKKQMPQPAF-----TLRRKLVF-P---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_rerio_ENSDARP00000024255 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EQYEMKGERRGVCLIINNYDFS--------ACGWLNREGTDIDHDS-LRDVFEW LGFE-ILTRRDCTGDQILQALMDLSTQ-DHT--QADCVVCCILSH--GRL-------ND- IIGVDGKAVPFKELME---TLSPFRCSSLYQKPKLFFIQ--ACR----GTQNQRAVFP-- QT--FTEDEDVLAS-------------------D-AGVP-RDSIPEMADYLMAMSTVP-- WYASYRDKSKGTWFIQSLCDNLRLLVP------RGNDLLSILTKVNADVSKK-------- --SDKSGLKKQMPQPEF-----SLTRTVVF-PPPGLP----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_gambiae_AGAP011949-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MDS ILEFELKSYDTTHPNRGIAVVINDS---------------ERREGSEKDVQD-VVATLEG LKFN-VRTFQDNTKKEIKKALYKVARE-DHN--ENDCLVIVAMAH--GKK-------DH- ITLKKE-KLRIDKLWA---SFVGNKCPSLIGKPKLVFIQ--TCR----GDNVDFGVASHE T---DSTP-------------------------CSVDPA-PGIIPMYADLLVMYSSYD-- RHISVRCKDKGSWFIQSLCQVLRANI-------AGKELISLLTQVSYIVSCQ-------T SITSDGETVKQIPSINS-----MLTKAFYF-VPKQTQQIS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >H_sapiens_ENSP00000365051 ------------------------------------------------------------ ---------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRL VEELQVDQLWDALLSRELFR-------------------P-------------------- ------------H------------------------------------MIEDIQRAGSG SRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKL----------- ----------------------------------------SKPTLENLTPVVL-----RP EIRKPEVLRPETPRPVDIGS-----------------------------GGFGDVGALES LRGNADLAYILSMEPCGHCLIINNVNFC-------RESGLRTRTGSNIDCEK-LRRRFSS LHFM-VEVKGDLTAKKMVLALLELAQQ-DHG--ALDCCVVVILSH--GCQASHLQFPGA- VYGTDGCPVSVEKIVN---IFNGTSCPSLGGKPKLFFIQ--ACG----GEQKDHGFEV-- AS--TSPEDESPGSNPEPDATPFQEGLRTF---D-QLDA-ISSLPTPSDIFVSYSTFP-- GFVSWRDPKSGSWYVETLDDIFEQWA-------HSEDLQSLLLRVSAAFLCK-------- ------GEGRLLRGSVSSWGWGFGVSRAGP-NQG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_mulatta_ENSMMUP00000033547 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------KLIKVSTENTENSVDSKSI-----------KSLE---PKIIHGSKSVD---- SGISLDYSYKMDYPEMGLCIIINNKNFH-------KSTGMGSRSGTDVDAAN-LRETFIN LKYE-VRNKNDLTCEEIVELMRNVSRE-DHS--KRRSFVCVLLSH--SEE-------GI- SFGTNG-PVDLKKITS---FFRVDCC---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_rerio_ENSDARP00000063081 ------------------------------------------------------------ ---------------MSKKESTQRILQHKVFLIDTLSVEASFILQNVQQAKLITQRDYNN LSD--------------------------------------------------------- ----------------------------------------------------------VS ERETKIIKLLDKLIGRGEETCQEFIDLLRQDCVLENFPVL-------------------- ------------------------------------------------------------ -----------------------------------------------------EGHAIFA SSVQKVSQYKITQNPRGICVIINNVDFT----------SMGERRGSDEDQNY-LAKVFRW LGFE-VVAHRNKTAAEMKNILQALGRT---V--DGDCFVCCVLSH--GVE-------EG- VCGTDGSLVSVDEIRN---PFTGVNCQKLVGKPKLFFIQ--ACR----GQRKQLRVNA-- QA--DGPGDGESEME------------------VDGDDF-DITIPSDTDFLIARSTTD-- GHVSYRKPDEGSWFIQSLCRNLEKHCP------LGADILTILLSVNNEVSIQ-------- -----GLHSKQMPVHEV-----AMRMKLILPPVNN------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_domestica_ENSMODP00000004412 ------------------------------------------------------------ --------------------------------------------MEESQRELFQKNRLRL VCELQVEPLWDLMLDRELFT-------------------R-------------------- ------------D------------------------------------MIEDIQR--AG TRRDQARQLVTDLQTRGKRALPIFISCLEATGQWDLAALLSESNTTLTQQPDPIDIKPVE MIRSGGL---------------RSTGRYTSMVSLHLLLLANSPFLYFIDAVLVSAHNLFP LELIKRQPTFSKVLSLLYKL-----------------------------------RFPFC PPPQVGQVYTLNSDPCGYCLIINNVDFC-------ASSGLSSRKGSNIDCEK-MHNRFQA LHFA-VEVERNLSAKGMGAALQQLAER-DHS--ALDCCVVVILSH--GCQASHIQFPGA- IHGTDGASISVERIVN---IFSGSRCPSLGGKPKLFFIQ--ACG----GDQRDHGFQV-- SS--NIPEDKSPGSDPETDATPFQN---NF---D-QPDA-VASLPTPSDILVSYSTFP-- GFVSWRDPKSGSWYIETLDRVLEEWA-------DREDLLHMLLMVSNAVSAR-------- ------GTYKQIPGCFN-----FLRKRFFF-KTK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_nigroviridis_ENSTNIP00000013855 ------------------------------------------------------------ --------------------------------------------MEERHKKILQRNRINL VSELEPLNLYDGLIEKGVFT-------------------H-------------------- ------------D------------------------------------MIDEIKC--SG ARRDQARQLVRDLETRGSRAFPAFLECLKETGYHSLAELLQNGAPTVQIQPP-------- --------------------------------------TPIPVDRPVIQPLPISPPLVPP EEPVSPVPKPSTPGRASPEV--------------------------------EYVTLKGR IRRDSLQSYRMEANPLGHCLIINNVEFE-------PKSGLSNRNGSNVDCDR-LERRFKA LNFT-VKVKTNLKQRQIRQELSALSKV-DHS--QYDCCVVVILSH--GTEVSHSRFPGA- VYGVDGQFVPVQHIAT---YLNGQYCPSLQGKPKLFFIQ--ACG----GDEKDTGFQV-- SP--DEFEPPVVGADDQTDAIPVSSSSDSLSMSD-EPDA-RASLPTSSDILVSYSTFP-- GYVSWRDPKAGSWYVETLDRVLEENA-------ALHDLVVMLTMVNDEVSQN-------- ---QAKGLYKQMPGSFN-----FLRKRLYFIAQP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_rerio_ENSDARP00000075645 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MDKTSNPNNSNQINRASPNEQEKIKTDE----------------- -------------------------------------------------PKRKNTSQEDK ENLHKGVQNNNSPKRQREPL-------------------------QSTCNISDHYPKRKR AVTEQKEWYSMSNRPLGYCLIINNYKFE--------SASLADRRGTDRDKDD-LTKVFEK MYFK-VEVRDDLQASDMRNVIKEFAEK-DHS--QMNAFVCCILTH--GEK-------GT- VLGTDGKQVPIRELSQ---PFA--ECRSLASKPKLFFIQ--ACQ----GNMRQQGLWMAH ER--ENTTEEEAYEE------------------DAHAAG-NYSIPMDADFLFAIATVE-- HFRSYRHITNGSIFIQVLCKQLERGCA------QKKDILSILTAVNGVVGSK-------- ----ILQGYKQMPEVRY-----TLTKALVL-PMNGVS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_gambiae_AGAP011950-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MDS LLELELQSYKTNHPNRGIAVVINDS---------------ENRDGWEKDLEA-VETVLQR LKCD-VRTFCDKTKHEIRDALRNVSKE-DHT--KSDCLVIVAMAH--GNN-------DK- ITLRRG-EMHIDELWT---DFVGNGCPSLIGKPKLVFIQ--SCR----GNKHDYLVGGAA V---DAVP-------------------------SPEKPI-CVEIPMYADLLVMYSSYD-- QYVSYRDKEEGSWFIQSLCQVLGANI-------AGKDLLTLLTHVSYLVSVRSFLMESEV NMVKRTGVLKQIPSINS-----MLTKAFYF-VDK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >P_troglodytes_ENSPTRP00000056642 ------------------------------------------------------------ ---------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRL VEELQVDQLWDALLSRELFR-------------------P-------------------- ------------H------------------------------------MIEDIQRAGSG SRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKL----------- ----------------------------------------SKPTLENLTPVVL-----RP EIRKPEVLRPETPRPVDIGS-----------------------------GGFGDVGALES LRGNADLAYILSMEPCGHCLIINNVNFC-------RESGLRTRTGSNIDCEK-LRRRFSS LHFM-VEVKGDLTAKEMVLALLELARQ-DHG--ALDCCVVVILSH--GCQASHLQFPGA- VYGTDGCPVSVEKIVN---IFNGTSCPSLGGKPKLFFIQ--ACG----GEQKDHGFEV-- AS--TSPEDESPGSNPEPDATPFQEGLRTF---D-QLDA-ISSLPTPSDIFVSYSTFP-- GFVSWRDPKSGSWYVETLDDIFEQWA-------HSEDLQSLLLRVSAAFLCK-------- ------GEGRLLRGSVSSWGWGFGVSRAGP-NQG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------