>D_rerio_ENSDARP00000065554 IYMRTHTQGMTIKPFSLLAIPFPISLSQM------------------------------- ---------------EILQN-SAFLRGLCRTSG-PADL-QYDNSSELFRISTYAKFPTTA AVT-ERSLARAGFYYTGLGDRVQCFRCNVTADNWQSGDCPAERHKQLSPNCSFIQSLPAT --ANLLSSSHS-------------------------AFSPLRNVAVLQLSAPATAAPSTT APSTSGQTEEQVGYLNMGFTNLAPSSPISSRGVEDMSHQRPPACHNPG-MRREQERLDTF Q-NWT-----------------------------------------LA---TVTPAELAK AGLYYLGQGDRV----------ACFSCGGQLG--SWEPGDRAVSEHQRHYPNCRFVRGDR A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DN--------------------------------------- -----------------------IPLSGG---------------GL-------------- SNV---SNSAMQQCEERLLTF-V---NWPS-RIPVRPDQLAKAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFPSRC---EYLLQEKGQEFVHQIQARFPRLFEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------TNGDSNSREF VDPP-------VVHLGPGED--RSE-----DAVMMNNPVV---KSALEMGFERGLVKQTV Q----------SKILTSGENYKTVQEL--VSDLLS--AEDEKR----EEERELLAEEMAS --DGFTFLKKHH---AALSQRLKS-VQSLMDHLLEENVISQKEYDSIRNCTSVKQQTGQL IDLVLSKGNAAAEVFRNWIKKNDVYLLRELMAQTNEAASPSQD----------------- -----------------------------------------------------------L --SD--LPMEEQLRRLQEERTCKVCMDKEVNIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKECAPSL---R KCPICRGMVKGT---VRTFLS--------------------------------------- ----- >T_rubripes_ENSTRUP00000043752 --LLSPDPPLGGPTFTLILLCFHTKMETL------------------------------- ---------------VQLKN-NPFLMGLCRNCP-PPDL-QYDNSSELYRISTFARFPT-S GVT-ERSLARAGWFYTGVGDRVQCFKCNVTAEGWQAGDCPTEKHRQLSPSCSFIQSLPST --SNLLSSSHS-------------------------AFSPLRIAPAIPLSG---AGPAVP NPS-ANQGEEPVGYLNMGFSAPPPSSPLISRGVEDMSHQR-PTCHNPN-MRREQDRLESF H-SWT-----------------------------------------LT---IITPAELAK AGFYYLSQGDRV----------ACFSCGGQLS--NWEPGDRAMSEHQRHYPNCRFVRGDR A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DN--------------------------------------- -----------------------ISLAGAAP------------GGL-------------- TNV---SNPAMQQSEERLLTF-V---NWPS-RIPVRPDQLAKAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EYLLQERGQDFVHQIQARFPRLFEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------TNGDTTSREF VDPP-------VVHLGPGEE--RSE-----DAVMMNTPVI---KSALEMGFERSLVKQTV Q----------SKILTSGENYRTVQEL--VSDLLS--AEDQKR----EEEKEMLAEAMAS ALDGFTFVKRHQ---AALIQRLKS-VEPVLEHLREQNVLSHEEYSGLKAQTSAQQQTARL IELVLTKGNAAAEVFRNWIQKNDVHLLRDLMAQSSEASSPSQD----------------- -----------------------------------------------------------L --SD--LPMEEQLRRLQEERTCKVCMDKEVNIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKECAPSL---R KCPICRGLVKGT---VRTFLS--------------------------------------- ----- >T_nigroviridis_ENSTNIP00000012883 --L----PALFEGLLPFILLCFDTKMETL------------------------------- ---------------VQLKN-NPFLMGLCRNCP-PPDL-QYDNSSELYRISTFARFPS-S GVT-ERSLARAGWFYTGVGDRVQCFKCNVTAEGWQAGDCPTEKHRQLSPSCTFIQSLPST --SNLLSSSHS-------------------------AFSPLRIAPAIPLSG---AGPAVP NPS-ANPGEEPVGYLNMGFSAPPPSSPLGSRGVEDMSHQR-PTCHNPN-MRREQDRLDSF H-SWT-----------------------------------------LT---IITPAELAK AGFYYLSQGDRV----------ACFSCGGQLN--NWEPGDRAMSEHQRHYPNCRFVRGDR A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DN--------------------------------------- -----------------------ISLAGAVP-GGLTSQLSGGVPTL-------------- SNV---SNPAMQQSEERLLTF-V---NWPS-RIPVRPDQLARAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EYLLQEKGQDFVHQIQARFPRLFEQQKLL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------TNGDTSSREF VDPP-------VVHLGPGEE--RSE-----DAVMMNTPVI---KSALEMGFERSLVKQTV Q----------SKILTSGENYRTVQEL--VSDLLS--AEDQKR----EEEREMLAEAMAS --DGFTFVKRHQ---AALIQRLKS-VEPVLEHLREQNVLSHEEYSGLKAQTSAQQQTARL IELILTKGNAAAEVFRNWIQKNDVHLLRDLMAQSSEASSPSQD----------------- -----------------------------------------------------------L --SD--LPMEEQLRRLQEERTCKVCMDKEVNIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKECAPSL---R KCPICRGLVKGT---VRTFLS--------------------------------------- ----- >O_latipes_ENSORLP00000006992 ----------------------------L------------------------------- ---------------VQLKN-SKFLMGLCRNGP-PSDL-QYDNSSELFRFSTFARFPT-S VVT-ERSLARAGWFYTGVGDRVQCFRCNVTAEGWLAGDCPTEKHRQLSPTCPFIQSLPST --TNLLSSSHS-------------------------AFSPLRIAQAMPVSSERRQGPAAS NPS-GGQSEEAVGYLNMAFSAPPPSSPLASRGVEDLSHQR-PTCHNPS-MRREQDRLDSF Q-PWA-----------------------------------------IS---IITPAELAK AGFYYLGQNDRV----------ACFSCGGQLS--NWEPGDRAVSEHQRHYPNCRFVRGDR A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DN--------------------------------------- -----------------------VPLVAGAT--ALSAAASSGALAL-------------- TSV---SNPSMQQSEDRRLTF-V---NWPS-RIPVRPEQLAKAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EYLLQEKGQDFVHQIQARFPRLFEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------TNGENSSREF VDPP-------VVHLGPGED--RSE-----DAVMMNTPVI---KSALEMGFERSLVKQTV Q----------SKILTSGENYRTVQEL--VSDLLS--AEDQKR----EEEREMLAEAMAS --DGFTFVKRHQ---AALIQRLKS-VEPVLEHLREQNVLSAEEYGSLLAQTSAQQQTARL IELVLNKGNAAAEVFRNWIQKNDVHLLRDLMAQSNEASSPSQD----------------- -----------------------------------------------------------L --SD--LPMEEQLRRLQEERTCKVCMDKEVNIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKECAPSL---R KCPICRGLVKGT---VRTFLS--------------------------------------- ----- >G_aculeatus_ENSGACP00000027283 ------------------------------------------------------------ ------------------KN-NPFLMGLCRNGP-PPDL-QYDNSSELFRISTFARFPA-S GVT-ERSLARAGWFYIGVGDRVQCFRCNVTAEGWQAGDCPTEKHRQLSPTCSFIQSLPST --TNLLSSSHS-------------------------AFSPLRIAPAV------------- -PA-VSQGEEPVGYLNMGFSAPPPSSPLSSRGVEDMSHQR-PTCHNPS-KRKEQDRLDSF H-PWT-----------------------------------------LS---IITPSELAK AGFYYLGQGDRV----------ACFSCGGQLS--NWEPGDRAVSEHQRHYPNCRFLSSGA A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AL-------------- NNV---SNPAMQQSDERLLTF-V---NWPA-RIPVRPDQLAKAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EYLIQEKGQEFVHQIQARFPRLFEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ANGDNNSREF IDPP-------VVHLGPGEE--RSE-----DAVMMNTPVI---KSALEMGFERGLVKQTV Q----------SKILTSGENYRTVQEL--VLDLLS--AEDQKR----EEEREMVAEAMAS --DGFTFVKRHQ---ATLIQRLKS-VEPVLEHLREQNVLSPDEYGGLKAQTSAQLQNGKL IELVLTKGNAAAEVFRNWIQKNDVHLLRDLMAQSNEAASPSQD----------------- -----------------------------------------------------------L --SD--LPMEEQLRRLQEERTCKVCMDKEVNIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKECAPSL---R KCPICRGLVKGT---VRTFLS--------------------------------------- ----- >T_guttata_ENSTGUP00000013125 ----------------------------L------------------------------- ---------------NTVED-SPFLTSIMRQSALCDEL-KYDLSCELYRMSTFSTFPMNT PVS-ERSLARAGFYYTGVQDKVKCFSCGLTLDNWQPGDNAMEKHKQLYPRCSFVQRMLSD --NNVGLSSRS-------------------------AFSPSIANS---------LPPSLH SIA-LSPSLEQVGYFSGSFSS-FPQDPVTTRAAEDLSFLS-PKLHNNS-MRTEDARLCTF Q-SWP-----------------------------------------LT---FLSPTDLAK AGFYYLGTADKV----------ACFTCGGQLY--NWEPKDNAVSEHRRHYPNCPFVENLI R----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DQ--------------------------------------- -----------------------QS----------------------------------- FNV---SNVSMQTHEARVKTF-L---NWPT-RIPVQPEQLADAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWIEHAKWFP-RC---EYLLRVKGREFVDQIQARFPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDPPVNEN LDPP-------IIHFEPGES--HSE-----DAIMMNTPVV---KAALEMGFSRRLIKQTV Q----------SKILVTGENYKTVNDL--VSDLLM--AEDETI----QEEKEKQLEEVAS --DDLYLIQKNR---MALFQRLTC-VLPILGSLLSAKVITELEHDVIKQKTQIPLQAREL IDTVLVKGNEAASIFRNCLRDCDPVLYKDLFVEKTIKYVPTED----------------- -----------------------------------------------------------V --SG--LPMEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKECAPSL---R KCPICRGIIKGT---VRTFLS--------------------------------------- ----- >O_anatinus_ENSOANP00000016616 -----VHKTTSRGETRPVSPATPTEYFVM------------------------------- ---------------NVVAN-SMFLSNLMNGNS-GYEL-KYDFSCELFRMSTYSTFPTNV PVS-ERSLARAGFYYTGASDKVKCFSCGLMLDNWKPGDSAIEKHKQLYPSCSFIQNLLQT --HNPGASSYS-------------------------AFCPPPLGS------------LSP TAT-ISPSLEPSGYFSGSFSS-FPLDPVTSRAIEDLSQPR-PHVDNSA-MSSEEARICTF Q-SWP-----------------------------------------LT---FLSPSALAK AGFYYTGPGDRV----------ACFTCGGKLS--NWEPKDDAMSEHRRHFPGCPFLERQT R----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DA--------------------------------------- -----------------------SR----------------------------------- FNV---SNASMQTHAARVKTF-L---NWPA-RIPVQPEQLASAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWIEHAKWFP-RC---EYMIRMKGQEFVNQIQARYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDTPVDES ADPP-------IIHFGPGEN--PAE-----DAIMMSNPVV---KAALEMGFSRRLVKQTV Q----------SKILTTGENYKTVNDL--VSDLLN--AEDETR----EEEKERQNEEMAS --DDLSLIRKNR---MALFQHLTC-VLPILDSLLSAGVISEQERDVIKQKTQTSLQAREL IDTVLVKGNAAANIFKNCLKEDDCILYKNLFVEKNMKYIPTED----------------- -----------------------------------------------------------V --SG--LPMEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKECAPSL---R KCPICRGTIKGT---VRTFLS--------------------------------------- ----- >G_gallus_ENSGALP00000035646 ----------------------------M------------------------------- ---------------NIMDS-SPLLASVMKQNAHCGEL-KYDLSCELYRMSTFSTFPVNV PVS-ERRLARAGFYYTGVQDKVKCFSCGLVLDNWQPGDNAMEKHKQVYPSCSFVQNMLSL --NNLGLSTHS-------------------------AFSPLVASN---------LSPSLR SMT-LSPSFEQVGYFSGSFSS-FPQDPVTTRAAEDLSHLR-SKLHNPS-MSTEEARLRTF H-AWP-----------------------------------------LM---FLSPAELAK AGLYYLGTADKV----------ACFTCGGQLS--NWEPKDNAMSEHRRHFPNCPFVENLM R----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DQ--------------------------------------- -----------------------PS----------------------------------- FNV---SNVTMQTHEARVKTF-I---NWPT-RIPVQPEQLADAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWIEHAKWFP-RC---EYLLRVKGGEFVSQVQARFPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDTPVDEN MD-P-------IIHFEPGES--PSE-----DAIMMNTPVV---KAALEMGFSRRLIKQTV Q----------SKILATEENYKTVNDL--VSDLLT--AEDEKR----EEEKERQFEEVAS --DDLSLIRKNR---MALFQRLTS-VLPILGSLLSAKVITELEHDVIKQKTQTPLQAREL IDTVLVKGNAAASIFRNCLKDCDPVLYKDLFVEKSMKYVPTED----------------- -----------------------------------------------------------V --SG--LPMEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKECAPSL---R KCPICRGTIKGT---VRTFLS--------------------------------------- ----- >E_caballus_ENSECAP00000000598 ------------------------------------------------------------ -----------------MED-STILSSWTVGNK--QKM-KYDFSCELYRMSTYSTFPTGV PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDNPIEKHKQLYPSCSFIQNLVSV --TSLESTSKN-------------------------TSSPMRNSF--------------- THS-LSPTLEHSGSFSGSYSN-LSPNLVNSRAVEDFSPLR-TNPYSYA-MSTEEARFLTY H-MWP-----------------------------------------LT---FLSPSELAR AGFYYIGPGDRV----------ACFACGGTLS--NWEPKDDAMSEHRRHFPNCPFLENSL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ET--------------------------------------- -----------------------LR----------------------------------- FSI---SNLSMQTHAARLRTF-M---YWPP-RVPVQPEQLASAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EFLISMKGQEFVDEIQARYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDTPGDEN ADPP-------IVHFGPGES--SSE-----DAVMMNTPVI---KAALEMGFSRSLVKQTV Q----------SKILTTGENYKTVNDI--VSALLN--AEDEKR----EEEKERQTEEMAS --DDLSLIRRNR---MALFQQLTC-VLPILDNLLKANVINKQEHDIIKQKTQIPLQAREL IDTVLVKGNAAANIFKNCLKEIDSTLYENLFVEKNMKYIPTED----------------- -----------------------------------------------------------V --SG--LSLEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCQECAPAL---R KCPICRGIIKGT---VRTFLS--------------------------------------- ----- >M_mulatta_ENSMMUP00000004536 ----------MHKTASQRLFPGPSYQNIK------------------------------- ---------------SIMED-STILSDWTNSNK--QKM-KYDFSCELYRMSTYSTFPTGV PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIEKHKQLYPSCSFIQNLVS- --ATLGSTSKN-------------------------T-SPMRNSF--------------- AHS-LSPTLEHSSLFSGSYSS-LSPNPLNSRAVEDLSPSR-TNPYSYA-MSTEEARFLTY H-MWP-----------------------------------------LT---FLSPSELAR AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPNCPFLENSL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ET--------------------------------------- -----------------------LR----------------------------------- FSI---SNLSMQTHAARMRTF-M---YWPS-SVPVQPEQLASAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EFLIRMKGQEFVDEIQGRYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDTTGDEN ADPP-------IIHFGPGES--SSE-----DAVMMNTPVV---KSALEMGFSRDLVKQTV Q----------SKILTTGENYKTVNDI--VSALLN--AEDEKR----EEEKERQAEEMAS --DDLSLIRKNR---MALFQQLTC-VLPILDNLLKANVINKQEHDIIKQKTQIPLQAREL IDTVLVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTED----------------- -----------------------------------------------------------V --SG--LSLEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCQECAPSL---R KCPICRGIIKGT---VRTFLS--------------------------------------- ----- >H_sapiens_ENSP00000227758 ----------MHKTASQRLFPGPSYQNIK------------------------------- ---------------SIMED-STILSDWTNSNK--QKM-KYDFSCELYRMSTYSTFPAGV PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVS- --ASLGSTSKN-------------------------T-SPMRNSF--------------- AHS-LSPTLEHSSLFSGSYSS-LSPNPLNSRAVEDISSSR-TNPYSYA-MSTEEARFLTY H-MWP-----------------------------------------LT---FLSPSELAR AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPNCPFLENSL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ET--------------------------------------- -----------------------LR----------------------------------- FSI---SNLSMQTHAARMRTF-M---YWPS-SVPVQPEQLASAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EFLIRMKGQEFVDEIQGRYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDTTGEEN ADPP-------IIHFGPGES--SSE-----DAVMMNTPVV---KSALEMGFNRDLVKQTV Q----------SKILTTGENYKTVNDI--VSALLN--AEDEKR----EEEKEKQAEEMAS --DDLSLIRKNR---MALFQQLTC-VLPILDNLLKANVINKQEHDIIKQKTQIPLQAREL IDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTED----------------- -----------------------------------------------------------V --SG--LSLEEQLRRLQEERTCKVCMDKEVSVVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCQECAPSL---R KCPICRGIIKGT---VRTFLS--------------------------------------- ----- >P_pygmaeus_ENSPPYP00000004357 ----------MHKTASQRLFPGPSYQN-K------------------------------- ---------------SIMED-STILSDWTNSNK--QKM-KYDFSCELYRMSTYSTFPAGV PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVS- --ASLGSTSKN-------------------------T-SPMRNSF--------------- AHS-LSPTLEHSSLFSGSYSS-LSPNPLNSRAVEDFSSSR-TNPYSYA-MSTEEARFLTY H-MWP-----------------------------------------LT---FLSPSELAR AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPNCPFLENSL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ET--------------------------------------- -----------------------LR----------------------------------- FSI---SNLSMQTHAARMRTF-M---YWPS-SVPVQPEQLASAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EFLIRMKGQEFVDEIQGRYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDTTGEEN ADPP-------IIHFGPGES--SSE-----DAVMMNTPVV---KSALEMGFNRDLVKQTV Q----------SKILTTGENYKTVNDI--VSALLN--AEDEKR----EEEKEKQAEEMAS --DDLSLIRKNR---MALFQQLTC-VLPILDNLLKANVINKQEHDIIKQKTQIPLQAREL IDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTED----------------- -----------------------------------------------------------V --SG--LSLEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCQECAPSL---R KCPICRGIIKGT---VRTFLS--------------------------------------- ----- >P_troglodytes_ENSPTRP00000007251 ----------MHKTASQRLFPGPSYQNIK------------------------------- ---------------SIMED-STILSDWTNSNK--QKM-KYDFSCELYRMSTYSTFPAGV PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVS- --ASLGSTSKN-------------------------T-SPMRNSF--------------- AHS-LSPTLEHSSLFSGSYSS-LSPNPLNSRAVEDISSSR-TNPYSYA-MSTEEARFLTY H-MWP-----------------------------------------LT---FLSPSELAR AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPNCPFLENSL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ET--------------------------------------- -----------------------LR----------------------------------- FSI---SNLSMQTHAARMRTF-M---YWPS-SVPVQPEQLASAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EFLIRMKGQEFVDEIQGRYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDTTGEEN ADPP-------IIHFGPGES--SSE-----DAVMMNTPVV---KSALEMGFNRDLVKQTV Q----------SKILTTGENYKTVNDI--VSALLN--AEDEKR----EEEKEKQAEEMAS --DDLSLIRKNR---MALFQQLTC-VLPILDNLLKANVINKQEHDIIKQKTQIPLQAREL IDTILVKGNSAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTED----------------- -----------------------------------------------------------V --SG--LSLEEQLRRLQEERTCKVCMDKEVSVVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCQECAPSL---R KCPICRGIIKGT---VRTFLS--------------------------------------- ----- >C_familiaris_ENSCAFP00000022277 ----------MHKTTSQRLVPG-SYQRIK------------------------------- ---------------RTMED-STILRNQTIGNK--QKI-KYDFSCELYRMSTYSTFPAGV PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKPGDNPVEKHKQLYPSCSFIHSLVSL --TSRDSTSKN-------------------------I-SAMRNSF--------------- THS-ISPTLEH-GSFSGSHSN-LAANPVSSRAGEDFSPLS-TNPYSYA-MSTEEARFLTY H-MWP-----------------------------------------LT---FLSPSDLAR AGFYYIGPGDKV----------ACFACGGTLS--NWEPKDDAMSEHRRHFPNCPFLENSL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ET--------------------------------------- -----------------------LR----------------------------------- FSI---SNLSMQTHAARLRTF-V---YWPS-SVPVRPEQLASAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EFLIRMKGQEFVDEIQARYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDTPGDEN ADPPNS-----FVHFGPGEN--HSE-----DTVMMNTPVV---KAALEMGFSRILVRQTV Q----------SKILSTGENYRTVNEI--VLALLN--AEDETR----EEEKERQTEEMAS --DDLSLIRRNR---MALFQQLTC-VLPILDNLLKANVINKQEHDIIKQKTQIPLQAREL IDTVLVKGNSAANIFKSCLKEIDSTLYKNLFVDKNMKYIPTED----------------- -----------------------------------------------------------V --SG--LSLEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCQECAPSL---R KCPICRGIIKGT---VRTFLS--------------------------------------- ----- >E_caballus_ENSECAP00000010270 ----------------------------M------------------------------- ---------------NIVEN-SVFLSNLMKSAN-MFEL-KYDFSCELYRISTYSTFPPGV PVS-ERSLARAGFYYTGINDRVKCFCCGLMLDNWKQGDNPTEKHKKLYPSCSFVQNLNSV --NISGATSQL-------------------------AFSSSVTNS--------------- THS-LLPSLENSGYFSGSYSS-FPSNPVNSGPNHDFSALR-TSPYHCA-MNTEKARLLTF Q-MWP-----------------------------------------LT---FLSPTDLAK AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHLRHFPNCPFVENQF E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DT--------------------------------------- -----------------------SR----------------------------------- YTV---SNLSMQTHAARFRTF-C---NWPS-SVQVPPEQLASAGFYY-MGHSDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EYLIRIKGQEFISRVQANYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDNPEDEN AESP-------IIHFGPGEN--HSE-----DAVMMNTPVV---KAALEMGFSRRLIKQTV Q----------SKILTTGENYKTISDL--VLELLN--AEDEMR----EEEKERATEEKES --GDLSLIRKNR---MALFRHLTC-VLPILDSLLTARVINEQEYDVIKQKTQTSLQSREL IDTILVKGNFAATIFKNSLQEIEPTLYKHLFVQQDIKYIPTED----------------- -----------------------------------------------------------V --SD--LPMEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKDCAPSL---R KCPICRGTIKGT---VRTFLS--------------------------------------- ----- >M_domestica_ENSMODP00000000728 -----THKTTSQRKT---CPLLFPKYSIM------------------------------- ---------------SVVED-GVLLSHLMSSDT--HEM-KYDLSCELYRMSTYSAFPVNV PIS-ERSLARAGFYYTGVNDRVKCFCCGLMLDNWKQGDNAIDKHKQLYPSCAFIQNLISV --N--LGSSQS-------------------------TFSSSVNNA--------------- TRS-LSLSSEQSGYFSGSYSS-FPLEPVTSRGVEDLSPLN-TSPYSYS-MSTEEARILTY Q-AWP-----------------------------------------LT---FLSPLDLAR AGFYYIGPGDMV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPHCPFLESQI Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------ET--------------------------------------- -----------------------SR----------------------------------- FNV---SNLSMQTHAARVKTF-V---TWPP-QIPVHPEQLANAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-R----QYLIRMKGQEFVDQVQARYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDIPGDEN AELP-------IIHFGPGEN--NSE-----DTVMMNTPVI---KAALEMGFSRSLVKQIV Q----------SKILTTGENYKTVNEV--VSDLLN--AEDEKR----KEEKERQTEEMAS --DDLTLIRKNR---MALFQHLTC-VLPILDSLLTSGVINEQEHDVIKQKTQTSLQAREL IDTILVKGNAAASVFKNCLREIGSVLYNNLFVEKNMKYIPTED----------------- -----------------------------------------------------------V --SG--LPMEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKECAPSL---R KCPICRGIIKGT---VRTFLS--------------------------------------- ----- >A_carolinensis_ENSACAP00000012475 ----------------------------L------------------------------- ---------------IIMNTFDTFAAKLKNVPD-VGQL-KYDLSCELFRMSTFSTFPLHV PVS-ERSLARAGFYYTGVKDKVKCYSCGLMLDNWKKGDNPLDKHKQLYPSCSVVQNLTSL --NNLGSSFYS-------------------------AFSPPSLSV---------GHSSSH SPQ-QTPNLDQVGYFSGSFSS-VPQEL--PKLTEGISHVR-PKVANSA-MSSEEARLLTF K-TWP-----------------------------------------LT---FLSPSSLAK AGFYYIGPADKV----------ACFVCGGHLG--NWEPKDNAMSEHRRHFPTCPFVE-QT Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------SQ--------------------------------------- -----------------------PG----------------------------------- FTV---SNLSMQTYRARVGTF-E---NWPM-TVPVLPQRLADAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWEEHAKWFP-RC---EYLIHRKGQEFVRCVQARFPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDIPVDEN TSPP-------IIRFEPGEN--GSE-----DEVIMKTPVV---EAALEMGFRRRLVKQIV Q----------SKILRTGESYKSINDL--VSDLIA--ADDEKR----DDEKEPQMEESTS ---DLSLIRKNR---VALFQRLTC-VLPILECLLASKAISSLEYQVIKQKTQTPLQAREL IDTILVKGNKAANIFRNCIQESDPVLYQDLFVEKNMTYIPA-D----------------- -----------------------------------------------------------V --SG--LSMEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKECAPSL---R KCPICRGTIKGT---VRTFLS--------------------------------------- ----- >C_familiaris_ENSCAFP00000022282 ----------------------------M------------------------------- ---------------NIVQN-SIFLSNLLRSSP-VFEL-KYDHSCELYRMSTYSTFPAGV PVS-ERSLARAGFYYTGAKDRVRCFCCGLMLDNWKAGDSPTGKHRNLYPSCSFIQNLSAV --STVGAASQP-------------------------PAPLSEARS--------------- THA-QSPGLERSSYFSASYSS-FPVDPVDFRPSPAMSPWR-AGPSCVT-MKSEEDRLCTF Q-GWP-----------------------------------------LA---FPLPSALAR AGFYYVGPGDRV----------ACFACGGKLS--NWEPDDDALSEHLRHFPDCPFVEGQL Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------AT--------------------------------------- -----------------------VR----------------------------------- YTA---SNLSMQTLAARSRTF-C---NWPP-RAPVHPEQLASAGFYY-MGHSDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EYLIRIKGQEFISQIQASYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDNTEDEN TESP-------IVHFGPGEY--HSE-----DAVMMNTPVV---MAALEMGFSRSLVRQTV Q----------SKILSTGENYRTVNEI--VSDLLH--VEDEIR----EEEKERAAENRES --DDVSLIRKNK---MVLFQHLTY-VLPILDSLLMAGVLNEQEHSSIKQKARTSLQAREL IDTVLVKGSSAVTIFKNSLQEIDPMLYKRFFVQQDRKYIPTED----------------- -----------------------------------------------------------I --SD--LPVEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCRDCAPSL---R KCPICRGTVRGT---VRTFLS--------------------------------------- ----- >P_troglodytes_ENSPTRP00000007250 ----------------------------M------------------------------- ---------------NIVEN-SIFLSNLMKSAN-TFEL-KYDLSCELYRMSTYSTFPAGV PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPIEKHKKLYPSCRFVQSLNSV --NNLEATSQP-------------------------TFPSSVTNS--------------- THS-LLPGTENSGYFGGSYSN-SPSNPVNSRANQDFSALM-RSSYHCA-MNNENARLLTF Q-TWP-----------------------------------------LT---FLSPTDLAK AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDNAMSEHLRHFPKCPFIENQL Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DT--------------------------------------- -----------------------SR----------------------------------- YTV---SNLSMQTHAARFKTF-F---NWPS-SVLVNPEQLASAGFYY-VGNSDDVKCFCC DGGLRCWESGDDPWVQHAKWFP-RC---EYLIRIKGQEFIRQVQASYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDSPRDEN TESS-------IIHFEPGED--HSE-----DAIMMNTPVV---NAAVEMGFSRSLVKQTV Q----------RKILATGENYRLVNDL--VLDLLN--AEDEIR----EEERERATEEKES --NDLLLIRKNR---MALFQHLTC-VIPILDSLLTAGIINEQEHDVIKQKTQTSLQAREL IDTILVKGNIAATVFRNSLQEADAVLYEHLFVQQDIKYIPTED----------------- -----------------------------------------------------------V --SD--LPVEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKDCAPSL---R KCPICRSTIKGT---VRTFLS--------------------------------------- ----- >M_mulatta_ENSMMUP00000004533 ----------------------------M------------------------------- ---------------NIVEN-SIFLSNLMKSAN-TFEL-KYDLSCELYRMSTYSAFPAGV PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPVEKHKKLYPSCRFVQSLNSV --NNSEATSQP-------------------------AFPSSVTNS--------------- THS-LLPGTENSGYFSGSYSS-FPSNPVNSRANQDFSALM-RSSYHCA-MNNEKARLLTF Q-TWP-----------------------------------------LT---FLSPTDLAK AGFYYVGPGDRV----------ACFACGGKLS--NWEPKDNAMSEHLRHFPKCPFIENQL Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DT--------------------------------------- -----------------------SR----------------------------------- YTV---SNLSMQTHAARFKTF-F---NWPS-SVLVNPEQLASAGFYY-VGNSDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EYLIRIKGQEFIRQVQASYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDSPEDEN AESS-------IIRFEPGED--HSE-----DAIMMNTPVV---NAAVEMGFSRSLVKYTV Q----------RKILATGENYRLISDL--VLDLLN--AEDEMR----EEERERATEEKES --NDLLLIRKNR---MALFQHLTC-VIPILDSLLTARIINEQEHDVIKQKTQTSLQAREL IDTILVKGNIAATVFRNSLQEADAVLYERLFVQQDIKYIPTED----------------- -----------------------------------------------------------V --SD--LPVEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKDCAPSL---R KCPICRSTIKGT---VRTFLS--------------------------------------- ----- >H_sapiens_ENSP00000376897 ----------------------------M------------------------------- ---------------NIVEN-SIFLSNLMKSAN-TFEL-KYDLSCELYRMSTYSTFPAGV PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSV --NNLEATSQP-------------------------TFPSSVTNS--------------- THS-LLPGTENSGYFRGSYSN-SPSNPVNSRANQDFSALM-RSSYHCA-MNNENARLLTF Q-TWP-----------------------------------------LT---FLSPTDLAK AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDNAMSEHLRHFPKCPFIENQL Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DT--------------------------------------- -----------------------SR----------------------------------- YTV---SNLSMQTHAARFKTF-F---NWPS-SVLVNPEQLASAGFYY-VGNSDDVKCFCC DGGLRCWESGDDPWVQHAKWFP-RC---EYLIRIKGQEFIRQVQASYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDSPGDEN AESS-------IIHFEPGED--HSE-----DAIMMNTPVI---NAAVEMGFSRSLVKQTV Q----------RKILATGENYRLVNDL--VLDLLN--AEDEIR----EEERERATEEKES --NDLLLIRKNR---MALFQHLTC-VIPILDSLLTAGIINEQEHDVIKQKTQTSLQAREL IDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTED----------------- -----------------------------------------------------------V --SD--LPVEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKDCAPSL---R KCPICRSTIKGT---VRTFLS--------------------------------------- ----- >M_musculus_ENSMUSP00000091422 ----------MDKTVSQRLGQGTLHQKLK------------------------------- ---------------RIMEK-STILSNWTKESE--EKM-KFDFSCELYRMSTYSAFPRGV PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPVEKHRQFYPSCSFVQTLLS- --ASLQSPSKN-------------------------M-SPVKSRF--------------- AHS-SP--LER----GGIHSN-LCSSPLNSRAVEDFS-SR-MDPCSYA-MSTEEARFLTY S-MWP-----------------------------------------LS---FLSPAELAR AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPHCPFLENTS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ET--------------------------------------- -----------------------QR----------------------------------- FSI---SNLSMQTHSARLRTF-L---YWPP-SVPVQPEQLASAGFYY-VDRNDDVKCFCC DGGLRCWEPGDDPWIEHAKWFP-RC---EFLIRMKGQEFVDEIQARYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDTPGEEN ADPTET-----VVHFGPGE---SSE-----DVVMMSTPVV---KAALEMGFSRSLVRQTV Q----------RQILATGENYRTVNDI--VSVLLN--AEDERR----EEEKERQTEEMAS --GDLSLIRKNR---MALFQQLTH-VLPILDNLLEASVITKQEHDIIRQKTQIPLQAREL IDTVLVKGNAAANIFKNSLKEIDSTLYENLFVEKNMKYIPTED----------------- -----------------------------------------------------------V --SG--LSLEEQLRRLQEERTCKVCMDREVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCQECAPSL---R KCPICRGTIKGT---VRTFLS--------------------------------------- ----- >P_pygmaeus_ENSPPYP00000004355 ----------------------------M------------------------------- ---------------NIVEN-SIFLSNLMKSAN-TFEL-KYDLSCELYRMSTYSTFPAGV PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPIEKHKKLYPSCRFVQSLNSV --NNLEATSQP-------------------------TFPSSVTNS--------------- THS-LLPGTENSGYFSGSYSS-FPSNPVNSRVNQDFSALM-RSSYHCA-MNNENARLLTF Q-TWP-----------------------------------------LT---FLSPTDLAK AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDNAMSEHLRHFPKCPFIENQL Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DT--------------------------------------- -----------------------SR----------------------------------- YTV---SNLSMQTHAARFKTF-F---NWPS-SVLVNPEQLASAGFYY-VGNSDDVKCFCC DGGLRCWESGDDPWVQHAKWFP-RC---EYLIRIKGQEFIRQVQASYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDSPGDEN AESS-------IIRFEPGED--HSE-----DAIMMNTPVV---NAAVEMGFSRSLVKQTV Q----------RKILATGENYRLVNDL--VLDLLN--AEDEIR----EEERERATEEKES --NDLLLIRKNR---MALFQHLTC-VIPILDSLLTARIINEQEHDVIKQKTQTSLQAREL IDTILVKGNIAATVFRNSLQEADAVLYEHLFVQQDIKYIPTED----------------- -----------------------------------------------------------V --SD--LPVEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKDCAPSL---R KCPICRSTIKGT---VRTFLS--------------------------------------- ----- >R_norvegicus_ENSRNOP00000007702 ----------------------------M------------------------------- ---------------NMVQG-SAFLAKLMKSAD-TFEL-KYDFSCELYRLSTYSTFPAGV PVS-ERSLARAGFYYTGVNDKVKCFSCGLMLDNWKQGDSPIEKHRKLYPSCSFVQTLNPA --NSLEASPQP-------------------------PLPSTATST--------------- MPS-GFAASESTGYFSGSYSS-FPSDPVNFRANQDCPAFS-TSPYHFA-MNTEKARLLTY Q-TWP-----------------------------------------LS---FLSPAELAK AGFYYTGPGDRV----------ACFACGGKLS--NWDRKDDPLSEHRRHFPSCPFLKDVG Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------FT--------------------------------------- -----------------------SQ----------------------------------- YTV---SNLSMQTHAARVRTF-S---TWPS-SALVHPQELASAGFYY-TGHSDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EYLIRIKGQEFVGQVQAGYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDSPEDET GEAA-------IVHLGPGEN---WE-----DAVMMNTPVV---KAALDMGFSRSLVRQTV Q----------RQILATGENYRTVSDL--VIGLLD--AEDEMR----EEQTEQEAEEEES --DDLTLIRKNK---MVLLQHLTP-VTPILDCLLSARVITEQEYDAVKQKPHT-LQARTL IDTVLAKGNTAATSFRNSLQEIDPGLYRDIFVRQNIRSLPTDD----------------- -----------------------------------------------------------I --AA--LPMEEQLRKLQEERTCKVCMDREVSLVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKECAPSL---R KCPICRGTIKGT---VRTFLS--------------------------------------- ----- >R_norvegicus_ENSRNOP00000014560 ------------------------------------------------------------ ----------------IMEN-STVLSNWTKENK--EKM-KYDFSCELYRMSTYSAFPRGV PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPTEKHRQFYPSCSFVQTLLS- --GGLQSAAKN-------------------------T-SPAKSRF--------------- AHS-LP--LEQ----GGIHSS-LPSNPLNSRAVEDFS-LR-MNPCSYA-MSTEEARFLSY S-MWP-----------------------------------------LS---FLSPAELAK AGFYYTGPGDRV----------ACFACGGKLS--NWEPNDDPLSEHRRHFPHCPFLENTS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ET--------------------------------------- -----------------------QR----------------------------------- FSV---SNLSMQTHSARMRTF-L---YWPS-SVLVQPEQLASAGFYY-VDHNDDVKCFCC DGGLRCWEPGDDPWIEHAKWFP-RC---EFLIRMKGQEFVDEIQARYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDTSEEEN ADPPER-----VVHLGPGE---NWE-----DAVMMNTPVV---KAALDMGFSRSLVRQTV Q----------RQILATGENYRTVSDI--VSALLN--AEDERR----EEEKERQSEETAS --GDLSLIRKNR---MALFQQLTC-VIPILDDLLEASVLTKEEHDIIRQKTQIPLQAREL IDTILVKGNAAASVFKNSLKEVDSTLYEHLFVEKTMKYIPTED----------------- -----------------------------------------------------------V --SG--LSLEEQLRRLQEERTCKVCMDREVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCRECAPSL---R KCPICRGTIKGT---VRTFLS--------------------------------------- ----- >X_tropicalis_ENSXETP00000048002 --------------------------MAN------------------------------- ---------------EILDR-RPDLAKRLKSNPSMCKI-TLEFSCELYRLSTFSTFPSNT HVS-ERNLAKAGFYYTGQDDKVKCFTCGLMLDNWKKGDNAFEKHKKLYPSCSFIQNVPSV ---NLGASLYS-------------------------AFSPPASNS---------TP---- MHA-ASAENDKVEAITLKYSS-IPQDPVTLRGIEDLSHVR-ISEY----MYTEEARLNSF Q-EWS-----------------------------------------NM---FLTPAELAK AGFYFVGPGDKV----------ACFTCDGKLN--NWEPNDNAMSEHRRHFPNCPFVKSST R----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------VS--------------------------------------- -----------------------SR----------------------------------- FSV---SNVSMQASSARLKTF-A---SWPP-RIPISPTRLAEAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EYLLHIRGQDYVQEVQERYPHLLDQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SSSENQ-NEA KNIP-------IIRLG-TEN--SQE-----DEIMMSTPMV---QTALEIGFNRRLVKRTI Q----------SKMLTSGENYSQLDDL--ISDLLI--AQEEQT----EEERNRQAEENSL --DDISVIRKSR---MALSQHIASRSIPILDYLLSSNDITAAEYEAIKLKTQPILQAQEM IETIITKGKTAVQTLKNCLQKHDPNLFRQLFTEQSLKCISLDD----------------- -----------------------------------------------------------Y --SD--LSMEEQLRRLQEERTCKICMDQEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKDCAPSL---R KCPICRGTIKGT---VRTFLS--------------------------------------- ----- >M_musculus_ENSMUSP00000013949 ----------------------------M------------------------------- ---------------NMVQD-SAFLAKLMKSAD-TFEL-KYDFSCELYRLSTYSAFPRGV PVS-ERSLARAGFYYTGANDKVKCFCCGLMLDNWKQGDSPMEKHRKLYPSCNFVQTLNPA --NSLEASPRP-------------------------SLPSTAMST--------------- MPL-SFASSENTGYFSGSYSS-FPSDPVNFRANQDCPALS-TSPYHFA-MNTEKARLLTY E-TWP-----------------------------------------LS---FLSPAKLAK AGFYYIGPGDRV----------ACFACDGKLS--NWERKDDAMSEHQRHFPSCPFLKDLG Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------SA--------------------------------------- -----------------------SR----------------------------------- YTV---SNLSMQTHAARIRTF-S---NWPS-SALVHSQELASAGFYY-TGHSDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EYLLRIKGQEFVSQVQAGYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDSPEDEN ADAA-------IVHFGPGES---SE-----DVVMMSTPVV---KAALEMGFSRSLVRQTV Q----------WQILATGENYRTVSDL--VIGLLD--AEDEMR----EEQMEQAAEEEES --DDLALIRKNK---MVLFQHLTC-VTPMLYCLLSARAITEQECNAVKQKPHT-LQASTL IDTVLAKGNTAATSFRNSLREIDPALYRDIFVQQDIRSLPTDD----------------- -----------------------------------------------------------I --AA--LPMEEQLRKLQEERMCKVCMDREVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKDCAPSL---R KCPICRGTIKGT---VRTFLS--------------------------------------- ----- >B_taurus_ENSBTAP00000034604 ----------------------------M------------------------------- ---------------NIVEN-SVFLSNLMKSAN-MFEL-KYDFSCELYRMSTYSTFPAGV PVS-ERSLARAGFYYTGVKDKVKCFCCGLMLDNWKQGDNPIEKHKKLYPSCSFVQNLNSI --NVSGASSQP-------------------------TFHYSLTNS--------------- THS-LLPSLENSGYFSGSYSS-FPSNLLNSGPNQDFSALR-ISSYPCA-MNTEKARLLTF Q-MWP-----------------------------------------LT---FLSPTDLAK AGFYYIGPGDRV----------ACFACGGTLS--NWEPKDDAMSEHLRHFPNCPFLGNQL Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GT--------------------------------------- -----------------------SR----------------------------------- YTA---SNLSMQTYAARIKTF-C---SWPS-SVPVHPEQLASAGFYY-VGHSDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EYLIQIKGQEFISRVQASYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDNPEDEN TESP-------RIERNANQN--HYE-----DMVQLSHPYM---TTGKTIGLTRRTFVGTV I----------CHILTTGLNYLTICQL--LFKLPN--PDRSFV----QQEVNKDTSENEK --DDLSLIRKNR---MALFQHLTC-VLPILDSLLTARVISEQEHDVIKQKTQTSLQAREL IDTILVKGNFAATIFKNSLQEIDPMLYKRLFVQQDIKYIPTEN----------------- -----------------------------------------------------------V --SD--LPMEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKDCAPSL---R KCPICRGTIKGT---VRTFLS--------------------------------------- ----- >O_cuniculus_ENSOCUP00000011948 -----------HKTTSPRVVPG-TVYRTQ------------------------------- ---------------NMMED-STILXXXXXXXX--XXX-XXXXXXXXXXXXXXXXSPNGV PVS-ERSLARAGFYYTRVNDKVKCFCCGLMLDNWKQGDNPIEKHKQLYPSCSFIQNLVS- --ASLDSTIKN-------------------------T-SPVRSSF--------------- AHS-LSPTVEPGGSFSGSYSS-LSANPLNSRTVEDFSPLR-TNPYSYS-MSSEEARFLTY H-MWP-----------------------------------------LS---FLSPSELAR AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPKCPFLENSL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ET--------------------------------------- -----------------------LR----------------------------------- FSI---SNLSMQTHASRMRTF-M---YWPS-SAPVGPEQLASAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-XX---XXXXXXXXXXXXXXXXXXXXXXXXX--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDPPGEEN ADPP-------IVHFGPGES--SSE-----DAVMMNTPVV---KAALEMGFSKSLVKQTV Q----------SKILTTGENYKTVNDI--VSALLN--AEDEKR----EEEKERQAEEVAS --DDLSLIRKNR---MALFQQLTC-VLPILDHLLKANVINKQEHDIIKQKTQIPLQAREL IDTVLVKGNVAANIFKNCLKEIDSTLYENLFVEKNMKYIPTED----------------- -----------------------------------------------------------A --SG--LSLEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCQGCAPSL---R KCPICRGIIKGT---VRTFLS--------------------------------------- ----- >M_domestica_ENSMODP00000000705 ----------------------------M------------------------------- ---------------NLVEN-IMFLSNMNISNL--YEL-KYDFSCELYRISTYSAFPVNV PVS-ERSLARAGFYYTGVNDRVKCFCCGLMLDNWKQGDNAIDKHKQLFPSCAFIQNLTSV --NNLESNSQS-------------------------ALSSSLNSA--------------- SCS-LSPSSEQSGYFSGSYSS-FPLEPVTSRGVEDLSPLN-TSPYSYS-MSTEEARILTY Q-AWP-----------------------------------------LT---FLSPLDLAR AGFYYIGPGDMV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPHCPFLESQI Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------ET--------------------------------------- -----------------------SR----------------------------------- FNV---SNLSMQTHAARVKTF-V---TWPP-QIPVHPEQLANAGFYY-VGCNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EYLIEMKGQQFINQIQASYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDVPVDEN AGLP-------IIHFGLGEN--HAE-----DAVMMNTSAV---RSALEMGFQRRLIKQTV Q----------SKILTTGENYKTVSDL--VSDLLK--AEDETR----EEDE--QAEEIES --DDLSLIQKNR---MALFQHLTC-VLPVLNCLLTASVINEQEYDVIKQKTQISLQVREL IDTIIVKGNIAANIFKKCLRDFDPVLYENLFVEKNMKYIPTED----------------- -----------------------------------------------------------V --SG------------------KIL----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >O_cuniculus_ENSOCUP00000008710 ----------------------------M------------------------------- ---------------NIVEN-SIFLANLMKSAN-TFEL-KYDFSCELYRMSTYSTFPAGV PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDKPIEKHRKLYPSCSFVQSLNSV --NNWEANSRS-------------------------TFPSSVTNS--------------- THS-FLPSWEHSGYYSGSYSS-LPSNPVNSRANQDFSAFR-VSPYHSA-MSTEKARLLTF Q-SWP-----------------------------------------LT---FLSPMDLAK AGFYYVGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHLRHFPNCPFVENQL Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DA--------------------------------------- -----------------------SR----------------------------------- YTI---SNLSMQTHAARFKTF-F---NWPS-SLLVHPEQLASAGFYY-VGHSDDVKCFCC DGGLRCWELGDDPWVEHAKWFP-RC---EYLIRIKGQEFISXXXXXXXXXXXX--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDTPEDEN AEPP-------XXXXXXXXX--XXX-----XXXXXXXXXX---XXXXXXXXXXXXXXXXX X----------XXXXXXXXXXXXXXXX--XXXXXX--XXXXXX----XXXXXXXXXXXXX --XDLSLIRRNR---MALFQHLTC-VIPILDSLLTSGVINEQEHAVIKQKTQTSLQAREL IDIILVKGNYPATVFQDCLPGFDPVFSMYLF----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >D_rerio_ENSDARP00000075338 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------G-MRSEEERLQTF H-NWP-----------------------------------------SDA--AVSPEELAR AGFHYLGYGDTV----------QCFCCEGILR--HWVDGDTPRGEHERHFPTCGLMRGRD V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN---VP--RGSSD--------------------------- --------------SVDDS----------------------------------------- ---------EMETEDNRRSTF-H---NWPT-GAAVQPDTLARAGFFY-TGHGDNVKCFFC DGGLRNWEPGDDPWQEHAKWFP-QC---EYLLQSRGQEYVRNVQQSFFNMNGR--GV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------RKNDAPQQQF MLSQPTFHPGTEVLGGQRSV-----------AAPMLSPVV---QAVLQMGFQHSLVESLV Q----------SRFLLTGAHYTSVSDL--VTDVLQ--AEEEEE----RQTGDTRSGVAHP LFANTLLYQNKIKLYYVCLKKKINMLKHFKSNLLNNYINKINNNNYSHNNFFYFTKKSLK MIFIIIKMQLTRIIYFHWFNINDVCLLRDCGDAENTKNDKNKN----------------- -----------------------------------------------------------A VRSD--LSPEEQLRQLQEERTCKVCMDKLVSMVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCSDCAASL---R HCPICRAVIRGS---VRAFMS--------------------------------------- ----- >O_cuniculus_ENSOCUP00000014265 -----MHKTASQRVV------PGTSYRIK------------------------------- ---------------SMMED-STISSNTNDQNQ---KM-KYDFSYKI-RVPTYSGLPIRV PLS-EWSLAPAGLYYIGMN-KVKCFCCDLMLDNWKQEYNLIEKHKQLYPSCSFSQNLISV ---SLESPLRS-------------------------SF---------------------- AHP-LFPTQGPCVSFSGSYPS-LSANPPNLTSV-DFSPLR-TS-LGYS-MSTEEAR---F Y-YKP-----------------------------------------FS---FLLPSEFAR AGFSNVAPGDAV----------AGFACDRKQS--NWK-KDDAMLE-WRHVPN-PFLEI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------LR----------------------------------- FSI---SNWSMQAH-AQMSTN-M---YWPS-SDPVCPEQLATVDFYY-VALSDDIKCFCC DGALR-FECGDDA-VEHAKLFA-RC---EFLMGVKG-EFVDEIQDRFPHLHQQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TSDPLGEEN ADPP-------IFHFGPGSS---SD-----DKGMMNTLVV---KSVLEMSFNISFAKETV H----------SKTLPTRENHKTVNDI--ASTLLN--AEDEKR----GEE--RQAEE--- --------RANS---MTLFQQLVC-VLPILNHLLKVNVINK-ENDIIRQK-QKPLQAIEL VDTVLLKGIVAANTFKNCLKDIDSMLYKN-FEKKNTKYFPTED----------------- -----------------------------------------------------------I --SC--PSLGDQLRRLQ-EVTFKMCIDKEVSILFIP------------------------ ------------------------------------------------------------ ------------------------------------------SSNLVVCQACAHSL---R KYPICRGIIKGT---VCTFLSK-------------------------------------- ----- >G_gorilla_ENSGGOP00000008137 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------RNSF--------------- AHS-LSPTLEHSSLFSGSYSS-LSPNPLNSRAIEDISSSR-TNPYSYA-MSTEEARFLTY H-MWP-----------------------------------------LT---FLSPSELAR AGFYYIGPGDRV----------ACFACGGKLS--NWEPKDDAMSEHRRHFPNCPFLENSL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ET--------------------------------------- -----------------------LR----------------------------------- FSI---SNLSMQTHAARMRTF-M---YWPS-SVPVQPEQLASAGFYY-VGRNDDVKCFCC DGGLRCWESGDDPWVEHAKWFP-RC---EFLIRMKGQEFVDEIQGRYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSDTTGEEN ADPP-------XXXXXXXXX--XXX-----XXXXXXXXXX---XXXXXXXXXXXXXXXXX X----------XXXXXXXXXXXXXXXX--XXXXXX--XXXXXX----XXXXXXXXXXXXX --XXXXXXXXXX---XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDKNMKYIPTED----------------- -----------------------------------------------------------V --SG--LSLEEQLRRLQEERTCKVCMDKEVSVVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCQECAPSL---R KCPICRGIIKGT---VRTFLS--------------------------------------- ----- >B_taurus_ENSBTAP00000046955 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------RC---EFLIRMKGQEFVSEIQARYPHLLEQ--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STANTSGDEN ADPP-------IVHFGPGES--SSD-----DAVMMNTPVV---KAALEMGFSRSLVKRTV Q----------SKILTTGENYKTVNDI--VSALLN--AEDEKREEEKEEEKERQTEETAS --DDLSLLRRNR---MALFQQLTC-VLPILDNLLKANVINKQEHDIIKQKTQIPLQAREL IDTVLVKGNSAASIFKNCLKEIDPTLYKNLFVEKNMKYIPT-D----------------- -----------------------------------------------------------V --SG--LSLEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCQECAPSL---R KCPICRGIIKGT---VRTFLS--------------------------------------- ----- >M_musculus_ENSMUSP00000110746 --------------------------MTF------------------------------- ---------------NSFEGTRTFVLA-------DTNK-DEEFVEEFNRLKTFANFPSSS PVS-ASTLARAGFLYTGEGDTVQCFSCHAAIDRWQYGDSAVGRHRRISPNCRFINGFYFE NGA-AQSTNPG-------------------------IQNGQY-KS--------------- --ENCVGNRNPF--APDRPPETHADYLLRTGQVVDISDT--IYPRNPA-MCSEEARLKSF Q-NWP-----------------------------------------DYA--HLTPRELAS AGLYYTGADDQV----------QCFCCGGKLK--NWEPCDRAWSEHRRHFPNCFFVLGRN V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------N--------------------------------------- -----------------------VRSESG-VSSDRNFPNST------------------- NSP---RNPAMAEYEARIVTF-G---TW---TSSVNKEQLARAGFYA-LGEGDKVKCFHC GGGLTDWKPSEDPWEQHAKWYP-GC---KYLLDEKGQEYINNIHLTHS-LEES--LG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------RTAEKT---- -----------PSL-TKKID--DT---------IFQNPMV---QEAIRMGFSFKDIKKTM E----------EKIQTSGSSYLSLEVL--IADLVS--AQKDNT----ED-ESSQTSL--- Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --KD--ISTEEQLRRLQEEKLCKICMDRNIAIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCKQCAEAV---D KCPMCYTVITFK---QKIFMS--------------------------------------- ----- >R_norvegicus_ENSRNOP00000009358 --------------------------MTF------------------------------- ---------------NSFEGSRTVVPA-------DTNK-DEEFVEEFNRLKTFANFPSSS PVS-ASTLARAGFLYTGEGDTVQCFSCHAAVDRWQYGDSAVGRHRRISPNCRFINGFYFE NGA-TQSTSPG-------------------------IQNGQY-KS--------------- --ENCVGNRNHF--ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA-MCSEEARLKTF Q-NWP-----------------------------------------DYA--HLSPRELAS AGLYYTGIDDQV----------QCFCCGGKLK--NWEPCDRAWSEHRRHFPNCFFVLGRN V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------N--------------------------------------- -----------------------VRSESG-VSSDRNFPNST------------------- NSP---RNPAMAEYDARIVTF-G---TW---LYSVNKEQLARAGFYA-LGEGDKVKCFHC GGGLTDWKPSEDPWEQHAKWYP-GC---KYLLDEKGQEYINNIHLTHS-LGES--VV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------RTAEKT---- -----------PSV-TKKID--DT---------IFQNPMV---QEAIRMGFNFKDIKKTM E----------EKLQTSGSNYLSLEVL--IADLVS--AQKDNS----QD-ESSQTSL--- Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --KD--ISTEEQLRRLQEEKLCKICMDRNIAIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCKQCAEAV---D KCPMCCTVITFK---QFLCLNPAPQ----------------------------------- ----- >C_familiaris_ENSCAFP00000034255 --------------------------MTF------------------------------- ---------------NSFEGAKTCVPA-------GINK-DEEFVEEFNRLKTFANFPSSS PVS-ASTLARAGFLYTGEGDTVRCFSCHASIDRWQYGDSAVGRHRKVSPNCRFINGFYFE NTA-AQPTNPG-------------------------IQNGQY-NA--------------- --ENYLRNRDHF--VLDRPSETHADYLLRTGQVVDISDT--TYPENPA-MYSEEARLNSF Q-NWP-----------------------------------------DYV--HLTPRELAS AGFYYTGIDDQV----------QCFCCGGKLK--NWEPCDNAWSEHRRHFPNCFFVLGRN V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------N--------------------------------------- -----------------------IRSESDVASTDRNVPNST------------------- SIP---ENPAMADYEARIVTF-R---MW---MCSINKEQLARAGFYS-LGDGDKVKCFHC GGGLTDWKPSEDPWEQHAKWFP-GC---KYLLEEKGQEYINNIHLTHSVVSHI--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------RTAERT---- -----------RSL-TERIE--DA---------IFQNPML---QEAIRMGFSFKDIKKIM E----------EKIQTSGSNYVSLEAL--VSDLVS--AQKDHT----QD-ESSQTSL--- Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --KE--ISAEEQLRLLQEEKLCKICMDRNIAVVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCKQCAEAV---D KCPMCYTVITFK---QKIFMS--------------------------------------- ----- >P_pygmaeus_ENSPPYP00000023167 --------------------------MTF------------------------------- ---------------NSFEGSKTCVPA-------DINK-EEEFVEEFNRLKTFANFPSGS PVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLE NSA-TQSTNSG-------------------------IQNGQY-KV--------------- --ENYLGSRNHF--ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA-MYSEEARLKSF Q-NWP-----------------------------------------DYA--HLTPRELAS AGLYYTGIGDQV----------QCFCCGGKLK--NWEPCDRAWSEHRRHFPNCFFVLGRN L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------N--------------------------------------- -----------------------IRSESDAVSSDRNFPNST------------------- NLP---RNPSMADYEARIFTF-G---TW---IYSVNKEQLARAGFYA-LGEGDKVKCFHC GGGLTDWKPTEDPWEQHAKWYP-GC---KYLLEQKGQEYINNIHLTHS-LEEC--LV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------RTTEKT---- -----------PSL-TRRID--DT---------IFQNPMV---QEAIRMGFSFKDIKKIM E----------EKIQISGSNYKSLEVL--IADLVN--AQKDST----QD-ESSQTSL--- Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --KE--ISTEEQLRRLQEEKLCKICMDRNIAIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCKQCAEAV---D KCPMCYTVITFK---QKIFMS--------------------------------------- ----- >B_taurus_ENSBTAP00000053449 --------------------------MTF------------------------------- ---------------NSFEGSKTCVPA-------DIDK-DEEFVEEFNRLKTFANFPSSS PVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAIGRHRRVSPNCRFINGFYFE NNA-AQPTYSG-------------------------VQNGQY-KA--------------- --ENYLGNRNHF--VLERPSETHAHYLLRTGQVVDLSDT--VYPRNPV-MCSEEARLKSF H-NWP-----------------------------------------DYA--HLTPRELAR AGLYYTGIDDQV----------QCFCCGGKLK--NWEPCDRAWSEHRRHFPNCFFVLGRN I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------N--------------------------------------- -----------------------MQSESSVVSSDRNFPNST------------------- NAP---INPAMADYEARIITF-G---TW---MYSVNKEQLARAGFYA-LGEGDKVQCFHC GGGLNDWKPSEDPWEQHAKWFP-GC---KYLLEEKGEEYVNNIHLTHS-IEES--LV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SHILNT---- -----------PSP-IFISD--DT---------IFQNPMV---QEAIRMGFSFKDIKKTM E----------GKIQTSGSNYKSLEVL--VADLVN--AQKDNT----QD-ESSQTSL--- Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --KD--ISTEEQLRLLQEEKLCKICMDRNIAVVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCKQCAEAV---D KCPMCYTAITLR---QKIFMS--------------------------------------- ----- >C_intestinalis_ENSCINP00000000045 ------------------------------------------------------------ --------------------------------------------MESYRLSTFMKYPQDT PVN-PRHLAAAGFHYTGYKDRVKCFCCGLCVESWCVGDD-VKSPRWHRSNCEFILGQDCG ---NQPIGSQN-------------------------ISVQQTARPV----PAGMIMKS-- ---GPSEFRFTFVILTF---LTLYSTRPKVELATIASPYHEQLVRSLD-LRKESDRFKTY E-NWP-----------------------------------------AQN-RTVYASDLAR SGFFYLGNLDRV----------QCFSCGGVLR--NWNYGDNITAEHRRHFPHCRFVRKKT V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------YQTANVLRGGFF--------------------- TNQ---FIPYMRNEESRFETFDH---RWPASNVRASPRQIAKAGFFF-LGDRDRVKCWYC NGGLQNWDPDDEPWTEHAKWFP-TH--REVVGKYKGPDFVHRMVSLYPNLPRP--IL--- RGPFDVPPRV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ANQRAPSPPPPIIDHKVAKQ--QEQ-----VNKFMLGDLV---KSATEMGFETSVIRRVV T----------RRLTSGGNLYTSVADL--VDDITA--NENEPN----SDDDDETNASQPS QTTTVKTPGDYDVINVTIVLRYIL-DRPIIHCKQEQTKWRPV-------KQKQQLEELFD RHFIKFFRNKVGIKSLKIITNIVWWWLRYVT----------------------------- ------------------------------------------------------------ ------PSMEARIRELQEERKCKICLDKVADIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLCTCTECAEAL---R KCPICRSKIRERDQNLHIYVGW-------------------------------------- ----- >E_caballus_ENSECAP00000017630 --------------------------MTF------------------------------- ---------------NSFEGSKTCVPA-------DIDK-DEEFVEEFNRLKTFANFPSSS PVS-ASTLARAGFLYTGEGDTVQCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYFE NNA-AQPTNPG-------------------------VQNGQY-KV--------------- --ENYLGNRNHF--VLGRPSETHAEYLLRTGQVVDISDT--IYPRNPA-MCSEEARLKSF Q-NWP-----------------------------------------DYA--HLTPGELAS AGLYYTGIDDQV----------QCFCCGGKLK--NWEPCDRAWSEHRRHFPNCFFVLGRN V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------N--------------------------------------- -----------------------IRSESDVVSSDRNFSNST------------------- NLP---RNPAMADYEARIITF-G---TW---IYSVNKEQLARAGFYA-LGEGDKVQCFHC GGGLTDWKPSEDPWEQHAKWYP-GC---KYLLEEKGQEYISNIHLTCS-LEES--LV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------RTAEKT---- ---------------TERID--DT---------IFRNPMV---QEAIRMGFSFRDIKKIM E----------EKIHTSGSNYRSLEIL--VADLVN--AQKDNT----QD-ESSQTSL--- Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --QE--ISAEEQLRLLQEEKLCKICMDRNIAVVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCKQCAEAV---D KCPMCNTVITFK---QKIFMS--------------------------------------- ----- >H_sapiens_ENSP00000360242 --------------------------MTF------------------------------- ---------------NSFEGSKTCVPA-------DINK-EEEFVEEFNRLKTFANFPSGS PVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLE NSA-TQSTNSG-------------------------IQNGQY-KV--------------- --ENYLGSRDHF--ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA-MYSEEARLKSF Q-NWP-----------------------------------------DYA--HLTPRELAS AGLYYTGIGDQV----------QCFCCGGKLK--NWEPCDRAWSEHRRHFPNCFFVLGRN L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------N--------------------------------------- -----------------------IRSESDAVSSDRNFPNST------------------- NLP---RNPSMADYEARIFTF-G---TW---IYSVNKEQLARAGFYA-LGEGDKVKCFHC GGGLTDWKPSEDPWEQHAKWYP-GC---KYLLEQKGQEYINNIHLTHS-LEEC--LV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------RTTEKT---- -----------PSL-TRRID--DT---------IFQNPMV---QEAIRMGFSFKDIKKIM E----------EKIQISGSNYKSLEVL--VADLVN--AQKDSM----QD-ESSQTSL--- Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --KE--ISTEEQLRRLQEEKLCKICMDRNIAIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCKQCAEAV---D KCPMCYTVITFK---QKIFMS--------------------------------------- ----- >P_troglodytes_ENSPTRP00000038304 --------------------------MTF------------------------------- ---------------NSFEGSKTCVPA-------DINK-EEEFVEEFNRLKTFANFPSGS PVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLE NSA-TQSTNSG-------------------------IQNGQY-KV--------------- --ENYLGSRNHF--ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA-MYSEEARLKSF Q-NWP-----------------------------------------DYA--HLTPRELAS AGLYYTGIGDQV----------QCFCCGGKLK--NWEPCDRAWSEHRRHFPNCFFVLGRN L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------N--------------------------------------- -----------------------IRSESDAVSSDRNFPNST------------------- NLP---RNPSMADYEARIFTF-G---TW---IYSVNKEQLARAGFYA-LGEGDKVKCFHC GGGLTDWKPSEDPWEQHAKWYP-GC---KYLLEQKGQEYISNIHLTHS-LEEC--LV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------RTTEKT---- -----------PSL-TRRID--DT---------IFQNPMV---QEAIRMGFSFKDIKKIM E----------EKIQISGSNYKRLEVL--VADLVN--AQIKGM----QD-ESSQTS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ISTEEQLRRLQEEKLCKICMDRNIAIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCKQCAEAV---D KCPMCYTVITFK---QKIFMS--------------------------------------- ----- >O_cuniculus_ENSOCUP00000008505 --------------------------MTF------------------------------- ---------------NSFEGSKTCVPA-------DINK-DEEFVEEFNRLKTFANFPSSS PVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYFE NSA-AQSTNPG-------------------------VQNGQY-KG--------------- --ENYLGNRNHF--ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA-MCSEEARLKSF Q-NWP-----------------------------------------DYA--HLTPRELAS AGLYYTGIDDQV----------QCFCCGGKLK--NWEPCDRAWSEHRRHFPNCFFVLGRN V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------N--------------------------------------- -----------------------IRSESDVVSSDRNFPNST------------------- NPP---RNPAMADYEARIISF-G---TW---IYSVNKEQLARAGFYA-LGEGDKVKCFHC GGGLTDWKPNEDPWEQHAKWYP-GC---KYLLEEKGQEYINNIHLTHS-LEES--LA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------RTAENT---- -----------PSQ-TKRID--DT---------IFQSPMV---QEAIRMGFSFREIKKIM E----------EKVQMCGSNYKSLEVL--VADLVN--AQKSST----QD-ESSQTSL--- Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --KE--VSTEEQLRRLQEEKLCKICMDRNIAVVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCKQCAEAV---D KCPMCYTVITFK---QKIFMS--------------------------------------- ----- >G_gallus_ENSGALP00000038337 --------------------------MTC------------------------------- ---------------NGPDSSESGATP-------ATDG-DQEWTQEHYRLGTFVEFPHDC PVS-ASALARAGFVYTGEGDKVKCFSCHVTVEGWEPGDSAIDRHKNLSPDCRFITGSAFL ENN-V---HPL-------------------------VQSHQH-RT--------------- --ENGSSNLALPS-ALEDLSDVEADYLLRTRQVVDMSDT--LYPKNPA-MCSEEARLKSF H-NWP-----------------------------------------PYG--LLTPKELAS AGLYYTGVGDQV----------ACFCCGGKLK--NWEPGDRAWSEHKRHFPKCFFVLGRD V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN--------------------------------------- -----------------------VSTDSICAELGRSCLNNE------------------- QHP---RNPSMAEYERRIQTF-L---AW---IYPVNKEHLAEAGFYS-TGNGDHVVCFHC GGGLQEWKENEDPWDQHAKWFP-GC---KFLRDEKGLEFINNVHLRDG-CRDS--T---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------IEAAEVT--ILP-----KDDLLQNQLV---QNAIHMGFSLSEIRSIM E----------KKLHLSGESYTSVEDL--VADLIS--AQKENI----KGEPPKESPL--- E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --QD--LSIEEKLRRLQEEKLCKICMAKDISVVLIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVACKECAEAV---N KCPLCCTNIIKR---QKIFM-Y-------------------------------------- ----- >M_domestica_ENSMODP00000018715 --------------------------MTF------------------------------- ---------------KSFEDSKTCVPP-------DINK-DEDFVEEFNRLKTFANFPSSS PIS-ASTLARAGFLYTGEGDTVKCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYFE KNA-TRFPNPI-------------------------IQNCQY-RV--------------- --ENCSRNRNHF--ALERPSETHGEYLLRTGQVIDMSDT--IYPRNPS-MCSEEARLRSF Q-NWP-----------------------------------------DYA--HLTPQELAS AGLYYMGFEDQV----------QCFCCGGKLK--NWEPCDRAMSEHKRHFPKCFFVLGRD V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN--------------------------------------- -----------------------TRIETD-VSCDRSCPNPT------------------- HLP---RNPAMADYEARLITF-A---TW---IYSVNKEQLAKAGFYA-LGDHDKVLCFHC GGGLTDWKPNEDPWEQHAKWYP-GC---KYLLEEKGQEYVSSIHLVHP-FNSS--MV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------KSRKMA---- -----------SSV-TQEID--DS---------VLQNPLV---QDAIRMGFNFLEIKKIM R----------EKIQSSGNNYTSLELL--VADLVS--AQKESS----QDGESSPTLS--- E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --KE--ISTEEQLRRLQEEKLCKICMDENIAVVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVSCQLCAEAI---D KCPMCYTVITFK---QKIFIRKPSPN---------------------------------- ----- >T_guttata_ENSTGUP00000003825 --------------------------AD-------------------------------- -----------------------------------TDG-AREWAQERERQGTFVGFPQGC PVS-VLALAQAGFVYTGEGDKVKCFSCNTTIEGWVPGDSALERHKKLAPTCKFITESAFL KSD-M---DPV-------------------------AQNYQN-RT--------------- --ENGTSNSALPC-ALDD-PDVEADYLLRTRQVVDMSDS--LYPKNPA-MCSEETRLKSF H-NWP-----------------------------------------LND--RLTPQELAN AGFYYTGVGDQV----------ACFCCGGKLK--NWEPSDRAWSEHKRHFPKCLFVQGRD I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN--------------------------------------- -----------------------VSSESIPSELGISGLNNA------------------- QHP---RNPSMTKYGKRLQTF-L---SW---IYPVAKERLAEAGFYS-VGNGDHVVCFHC GGGLQEWKENEDPWDQHAKWFP-GC---RFVSNEKGIEFINNVHLKDG-CRDS--TV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SVLLIN---- -----------HFVEIAKIN--IV---------LYENPWV---QSAIAMGFSLSEIRNTM E----------KRLQMTGESHTSVEDL--VADL-S--AHTENT----REEEPNEIPV--- E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --QDELIHTEEKLRRLQEEKLCKICMAKDVSVVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVACKECAQLL---N ECPLCRSDIMKI---QEIFM-Y-------------------------------------- ----- >C_intestinalis_ENSCINP00000005161 ------------------------------------------------------------ -----------------------------------------DSAMESYRLSTFMKYPQDT PVN-PRHLATAGLYFTGYKDRVKCFCCGLATEQWQFGDD-EKSPRWHRSNCEFIQGHDCG ---NIPIGLHC-------------------------VVKYKLLMEL----TIPIFLGSWG WIRPDNTARENFMN-VTYLNLGEKNFFQRIELATISSVYHEQVLRSLD-LKKEGERMKSF E-NWP-----------------------------------------TQN-RTVNPSDLAR SGFFYLGNLDRV----------QCFSCGGVLR--NWNYGDNITAEHRRHFPHCRMTQGT- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- -----------------------------SNNRELEMMFPC------------------- QHP---VNSHMRHLDSRIVTFDS---RWPKNKTQATIQQIAKAGFFY-LGERDRVKCWYC NGGLQNWDPDDEPWTEHAKWFP-TC---EFLIRSKGPDFVHHMVSLYPNLPRP--IL--- QTAQGANGS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QSSGTSS-- --------APIIIDPQKRKL--REK-----LNLEMDRDIV---KCVNDMGFELKHIRLCV K----------RKLEKENIGFSSAQQL--IDEILKLNLDEEEE----EELDLETDPKEPA AMET-EGGKLYHEVKPSNFKRYLD-QRCTINIRLKLDLTTIVMHRFINQRFIPYVNTVRL ETTNRSKNDLYYFKYLKQNWLTNGACMVDLT----------------------------- ------------------------------------------------------------ ------MSMQDRLLELQNERKCKICVDKLSDIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLCVCQACKSKV---A RCPICKSKVEKS---IRTYMS--------------------------------------- ----- >T_nigroviridis_ENSTNIP00000006583 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MRREKDRIRTF R-EWP-----------------------------------------ADA--AVAPADLAK AGFFFLGPRDAV----------QCFCCGGILR--CWVQGDSPGDEHRRHFPTCCFILGRA V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN---IPLQAGSSD--------------------------- --------------SVD------------------------------------------- ---------EMEAEDSRLTTF-H---NWPT-EASVQPDVLARAGFFY-TGHGDNVKCYYC DGGLRNWEPGDDPWQEHAKWFP-RC---EFLIQTRGQEYISNIQDAHFHLGDT--L---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SSSSRDI GPRNASPLP--DMIGGLAAS-----------SA-LLSPVV---QTVLQMGFDSSLVESLV Q----------TKYLLTGRQYTSVSNL--VSDVLQ--AEQEDR----ETAPQSRVSKSGG CLRWCSYCVCSCCDYLVC---AFQSQRRGRAPVL-----------LASEHIWPLEKK--- --------------------LSHLSFLREPALIPLTV----------------------- ------------------------------------------------------------ --NE--PSPEELLRQLQEERTCKVCMDKLVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCSDCATSL---R HCPICRAVIRGS---VRAFMS--------------------------------------- ----- >X_tropicalis_ENSXETP00000035327 ------------------------------------------------------------ ------------LAEFVLKEEMTCQCPKMSDGAYDMDV-DQNYFEEEVRLASFANFPSSY PVS-APALARAGFYYTGDGDRVKCFSCLAMVEGWQHGDTAIGKHRKISPNCKFINGFNNL RSDCILTQVPV------------------------------------------------- --MQNGFQNSAEDLAERSSSEIMADYLLRTGRVVDMSTP--KYPRHME-MCSEEARLQTF Q-NWP-----------------------------------------AYS--PLTPKELAN AGLFYTGINDQV----------KCFCCGGKLM--NWEPSDKAWTEHKKHFPECYFVLGRD V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN--------------------------------------- -----------------------VATEANTHGGRRRG----------------------- SEL---ACPAMNDYNARLETF-S---SW---SFPIDKETLAKAGFYS-IGDGDATKCFHC GGVLNCWSATDDPWEEHAKAYP-GC---KFLIDEKGQHFINHAQLKRPILHKA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------NSADASPALP K-----------------------------DSNLLKSPLV---TNAQQMGFPLEEIKKVM G----------QKLKTTGKNYTCVEEF--VSDLC---AQKETV----LEKPKEIE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ISLEEKLRQLEEEKICKVCMDRRISIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVACAVCADVL---D KCPICCTIVERR---QKIFMS--------------------------------------- ----- >G_aculeatus_ENSGACP00000003419 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MTDDRGTAPRAPEAPR-MRGEGERLRTF G-RWP-----------------------------------------ADA--PVTSGELAG AGFFYLGPGDEV----------QCFCCGGVLK--CWARGDRPAAEHRRHFPDCGFALGRP A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN---VPLPAGSSD--------------------------- --------------SVDGQLLSQLQRMTMDEQGTP------------------------- GQA---VHPQLEAEDTRVTTF-H---NWPA-EASVQPDVLARAGFFY-TGHGDNVKCFHC DGGLRNWEPGDDPWQEHAKWFP-RC---EFLIQERGQDYISNVQDSHFHLDDT--VS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GSQSSAGRDA GSRN-------DVVGGLAAS-----------SA-MLSPVV---QTVLQMGFEAALVESLV R----------TRFLLTGQHYTSVSNL--VSDVLQ--AEQEDQ----RGSRSAGNTERSE ------------------------------------------------------------ --------------------------------FPRTA----------------------- ------------------------------------------------------------ --TD--PSPEELLRQLQEERTCKVCMDKLVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCADCAASL---R HCPICRAVIRGS---VRAFMS--------------------------------------- ----- >T_rubripes_ENSTRUP00000011958 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MLEEPR-MRREGDRIRTF Q-EWP-----------------------------------------ADA--AVAPADLAR AGFFFLGPGDAV----------QCFCCGGILR--CWMQGDTPGDEHRRHFPTCCFVLGKA V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN---IPLQAGFSD--------------------------- --------------SVDGQLLSQLQRMTMDDQGTV------------------------- GQA---VYPEMEAEDSRLTTF-H---NWPT-EASVQPDVLARAGFFY-TGHGDNVKCYYC DGGLRNWEPGDDPWQEHAKWFP-RC---EFLIQTRGQEYISNIQDTHFHLGDT--VG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GSQSSSSRDI GPRNASHLP--DMV-----------------RA-MLSPVV---QTVLQMGFEAGLVESLV Q----------TKYLLTGRQYTSVSDL--VSDVLQ--AEQEDR----ARAPQSTVPSRSR ----------------------------------------------ASAHFSP------- ---------------------------------PPTV----------------------- ------------------------------------------------------------ --NE--PSPEELLRQLQEERTCKVCMDKLVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCSDCAASL---R HCPICRAVIRGS---VRAFMS--------------------------------------- ----- >G_gorilla_ENSGGOP00000005705 ----------------------------M------------------------------- ---------------NIVEN-SIFLSNLMKSAN-TFEL-KYDLSCELYRMSTYSTFPAGV PVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPIEKHKKLYPSCRFVQSLNSV --NNLEATSQP-------------------------TFPSSVTNS--------------- THS-LLPGTENSGYFSGSXSN-SPSNPVNSRANQDFSALM-RSSYHCA-MNNENARLLTF Q-TWP-----------------------------------------LT---FLSPTDLAK AGFYYIGPGDRV----------ACFXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXX X----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------XX--------------------------------------- -----------------------XX----------------------------------- XXX---XXXXXXXXXXXXXXX-X---XXXX-XXXXXXXXXXXXXXXX-XXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXX-XC---EYLIRIKGQEFIRQVQASYPHLLEQ--XX--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------XXXXXXXXXX XXXX-------XIHFEPGED--HSE-----DAIMMNTPVV---NAAVEMGFSRSLVKQTV Q----------RKILATGENYRLVNDL--VLDLLN--AEDEIR----EEERERAXXXXXX --XXXXXXXXXX---XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----------------- -----------------------------------------------------------X --XX--LPVEEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCKDCAPSL---R KCPICRSTIKGT---VRTFLS--------------------------------------- ----- >C_intestinalis_ENSCINP00000009820 ------------------------------------------------------------ -----------------------------------------DAAMESYRLSTFMKYPQDT PVN-PRHLAAAGFHYTGYKDRVKCFCCGLCVENWVSGDE-IKSKKWHRNNCELVNGNGSG ---NQPIAGDD-------------------------F--KSTISPLCECKALSMVLKT-- ---PKIQGCRKFSMPLSFFV--------RIELATIASPYHEQLVRSLD-LRKESDRSKTY E-NWP-----------------------------------------AQN-RTVYASDLAR SGFFYLGNLDRV----------QCFSCGGVLR--NWNYGDNITAEHTRHFPHCSLF---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------YAQLELSEMFPC------------------- QYP---VNPHMRNQDMRLATFDQ---RWQQRALQAKPAQISKAGFFF-LGDRDRVKCWYC NGGLQNWDPNDEPWTEHAKWFP-TC---EFLIRSKGPDFVHAMVSKYPNLPRP--IL--- RGPFDVPPSI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------RR----NSE--STA-- --------PPPIMDHKMAEM--KTK-----VKKHMESEEA---KSVLEMGFGRKELEKVI K----------KKLKKDGKMFKSVVSI--IDAM------NDGT----DSSDDEMEADEPQ TQTPMSI-SDLGRKGLF----------PCIGCILKIV----I-------RFKNHINTKYK TNYHKVHTPQIKIK----------YYPTDLS----------------------------- ------------------------------------------------------------ ------PSMLARVAELEEERKCKVCLDKMADIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLCTCIECASAL---N KCPICRKRIEKS---IRTYLN--------------------------------------- ----- >X_tropicalis_ENSXETP00000030727 ----------------------------N------------------------------- ---------------EILDR-RPDLAKRLKSNPSMCKI-TLEFSCELYRLSTFSSFPSNT HVS-ERNLAKAGFYYTGQDDKVKCFTCGLMLDNWKKGDNAFEKHKKLYPSCSFIQNVPSV ---NLGASLYS-------------------------AFSPPASNS---------TP---- MHA-ASAENDKVEAITLKYSS-IPQDPVTLRGIEDLSHVR-ISEY----MYTEEARLNSF Q-EWS-----------------------------------------NM---FLTPAELAK AGFYFVGPGDKV----------ACFTCDGKLN--NWEPNDNAMSEHRRHFPNCPFVKSST R----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------VS--------------------------------------- -----------------------SR----------------------------------- FSV---SNVSMQASSARLKTF-A---SWPP-RIPISPTRLAEAGFYY-VGRNDDV----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >O_latipes_ENSORLP00000010149 ------------------------------------------------------------ ------------------------------------------------------------ -VS-PLQLAEAGFLFTGVSDRVRCFSCQKTVENWSQEDQPVDRHIQVSPSCTFLRCTHFN RFK--------------------------------------------------------- ----SNPHMPLSNGGLHDGTEGYIDYQLRTRAIVDET----PYPRNRN-MKSEEARLETF S-SWP-----------------------------------------RSA--PVRPRDLAQ AGLFYLGKEDKV----------ECFSCGGKLS--GWKPGDTPWNEHEKHFSHCFYILGHD V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN--------------------------------------- -----------------------VPLERDGGENEETGSRN-------------------- QHR---TPVNLENLDERLGTF-A---RV---QHPIDHELLAKAGFYSKVGEGDEVICFRC GGGLKDWDPEDNPWEEHAKYYP-GC---SFLLSEKGQEFVNTIQLQEPKYSQQ------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------VRHIISPHLRNLFLKLLHFPSFCRNTKKV---YFVLCLAYSLLKSWWGS T----------FLMSSDKRIYKKLQNI--KMDFLK--RRKLAEPFEKENLSQGSATFSTC RANQLWIFHRNKTVIKINLFEIVRTFNRGLHDFLSSLYLSARNLMKNILVFFNMRATKSF VGVKLKVKKHYLLQFYINYIRTGLTI---------------------------------- ------------------------------------------------------------ ------ENPLEELEKLRQEKRCKICLDENACIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLASCKACSNKL---N QCPICCAAIAQK---IRTFIA--------------------------------------- ----- >X_tropicalis_ENSXETP00000029187 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------VPPN-MRSEAERQRSF R-AWP-----------------------------------------HTC-RTVSPAELAR SGFYYLGPGDRV----------QCFSCGGVLR--SWEPGDRPDTEHRKFFPSCPFLQVRR G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PPGGTD--------------------------- --------------SVDGQILGQLSGEEPDRT---------------------------- WEP---VCPQMAGEGDRLGSF-S---TWPR-YANGDPQQLAGAGFFY-TGHRDHVKCFHC DGGLRNWEQGDDPWTEHAKWFP-MC---DFLLQVKGEAFIRSVQESFFSSPET------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SPESVGSYEGSPVSSP GSPP--------------------------VCPFLSTSVA---QGALQVGFKRNRVSSLM I----------NRFILTGSCYGSVSEL--VTDLIR--AEEIHG----TESVSVPRAPTQR ERPEPPKEPAPP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LSTEEQLRQLKEERMCKVCMDNDVSMVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCTECAPNL---R HCPICRAAIRGS---VRAFMS--------------------------------------- ----- >T_rubripes_ENSTRUP00000010298 ------------------------------------------------------------ ---------MNPFDNMQLKKEITMEDQQHDSGTLETDS-AEDFSLITSRLESFRGSNLVQ LVP-AERLARAGFHFIGPSDRVRCFSCHKTVENWCTGDRPVERHKEVSPFCKFLSCIYRT SSN--------------------------------------------------------- ----PIPGTSLTNGSAYNEEAEDMEYRLRTGQVVDES----IYPVVPH-MRSEESRLHTF S-TWP-----------------------------------------LTA--PVSPCDLAQ AGLYYLGQCDQV----------QCFCCGGTLA--DWEIGDSAWAEHSKHFPFCFFILGHD V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN--------------------------------------- -----------------------IPFQGS-IEEEGSGRL--------------------- HTS---AAVHMGTFEERLRSF-A---GV---NHPLNIERLARAGFYS-NGTEDMVLCFCC NGGLKGWQPEEDPWEQHARHYP-GC---RFLLAEKGQEFVNHIQLQMPRQKKA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------NGFSAATNGTDT Q--TIIHFLRNAIGQALESSIRTVLIARHTVNLLLVQKSSPRVTAAMNRQY--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------DDPLEKLQKLQREKLCKICMDKDIDIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCNECSVSL---I KCPICCGDIRQK---VKTYIT--------------------------------------- ----- >O_anatinus_ENSOANP00000006435 --------------------------MTC------------------------------- ---------------NSPEELRTSNPS-------EVNK-DEEFAEEHNRLRTFANFPSTS PVS-SSTLARAGFLYTGEEDVVRCFSCHVAVDRWQYGDSAIGRHRKISPNCRFVNGCHFK NCA-LPLANAS-------------------------LQNGELGQV--------------- --EECPGNPSHH--ALERSSETHSDYLLRTRQVVDLSDT--VFPKNPA-MCSEEARLETF Q-NWP-----------------------------------------EYT--LLSPGQLAR AGLYYSGIDDQV----------ECFCCGGKLK--NWEPCDRPWSEHKRHFPKCLFVLGRD V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN--------------------------------------- -----------------------IEIESDSIASQRSYSNST------------------- HFP---RNPAMAEFEARIHTF-E---TW---TYSIDKELLARAGFYT-LGEQDKVICFHC GGGLTDWKPNEDPWEQHAKWFP-GC---KYLVEQKGQEFINNVHLTQS-LEDS--VL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------EADETP---- -----------PSL-TKAIT--II---------VFQNLVVGQLAEARAMLYKFYHAHTSI C----------KVVTIRKLVYSPLEML--TKSVSK--GREANS-----NPKSTHYFLFFP S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --VE--ISPEEELRRLQEEKLCKICMDKNIAVVFLP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVACKECGEAM---G KCPVCCTLINYR---QKIFMS--------------------------------------- ----- >D_melanogaster_FBpp0086432 ------------------------------------------------------------ -------------------------------------MTELGMELESVRLATFGEWPLNA PVS-AEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSPICSMVLAPNHC GNV--------------------------------------------------------- ------------------------PRSQESDNEGNSVVDSPESCSCPD-LLLEANRLVTF K-DWP-----------------------------------------NP---NITPQALAK AGFYYLNRLDHV----------KCVWCNGVIA--KWEKNDNAFEEHKRFFPQCPRVQMGP L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------IEFATGKNLDELGIQPT------------------- TLP---LRPKYACVDARLRTF-T---DWPI-SNIQPASALAQAGLYY-QKIGDQVRCFHC NIGLRSWQKEDEPWFEHAKWSP-KC---QFVLLAKGPAYVSEVLATTAANASS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------QPATAPAPTLQ-----ADVLMDEAPA---KEALALGIDGGVVRNAI Q----------RKLLSSGCAFSTLDEL--LHDIFD--DAGAGAALEVREPPEPSAPFIEP CQATTSKAASVPIPVADSIPAKPQAAEAVANISKITDEIQKMSVATPNGN---------- ------------------------------------------------------------ ------------------------------------------------------------ ------LSLEEENRQLKDARLCKVCLDEEVGVVFLP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLATCNQCAPSV---A NCPMCRADIKGF---VRTFLS--------------------------------------- ----- >G_gorilla_ENSGGOP00000008442 --------------------------MTF------------------------------- ---------------NSFEGSKTCVPA-------DINK-EEEFVEEFNRLKTFANFPSGS PVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLE NSA-TQSTNSG-------------------------IQNGQY-KV--------------- --ENYLGSRNHF--ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA-MYSEEARLKSF Q-NWP-----------------------------------------DYA--HLTPRELAS AGLYYTGIGDQV----------QCFCCGGKLK--NWEPCDRAWSEHRRHFPNCFFVLGRN L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------N--------------------------------------- -----------------------IRSESDAVSSDRNFPNST------------------- NLP---RNPSMADYEARIFTF-G---TW---IYSVNKEQLARAGFYA-LGEGXKVKCFHC GGGLTDWKPXEDPWEQHAKWYP-GC---KYLLEQKGQEYINNIHLTHS-LEEC--L---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >A_carolinensis_ENSACAP00000011315 ------------------------------------------------------------ ---------------------------------------------ELSRQQTFASFPSDC PVS-SAALAQAGFFYTGERDQVKCFSCHTMVEGWQEGDSAIERHRTIFPECRFINDIDIG RNNTYS------------------------------LLNCQHAS---------------- --ENGSASTSQQQPSLDESSDLDADYLLRTGQVVDLSGS--LYPRNPA-MCSEEARLRTF H-NWP-----------------------------------------PYA--PVTPQDLAH AGLYYTGIGDQV----------ECFCCGGKLK--NWEPSDQAWSEHRRHFPRCFFVLGHD L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NRSNNV------------------- VLP---QNPCMADYETRLKTF-V---AW---HYLVSKEQLARAGFYS-IGNGDSVACFHC GGGLQEWKAYEDAWEQHAKWFP-GC---KYVLEEKGQDFVNRV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >A_aegypti_AAEL006633-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------E-LKREEHRLATY V-NWP-----------------------------------------IS---HISPSSLAK AGFYYTYNADQV----------KCAWCEGVIG--QWELGDDPFVEHQKFFPNCAKVISNG I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSNPILDPTIGIQPV------------------- KTP---YAPQFSSLDSRIRSF-E---NWTT-GHIQDPERLAQAGFYY-LGRADEVHCFYC DGGLRFWLADDDPWFEHARCFP-KC---QFVQLVKGQLFIENVQSQIKSTSSN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------QQQQMQASGPTMS-----LDEALATEPV---QLALSMGLNAGRIRAVT K----------RQLDSTGHPYADSQAL--IEAVLDGQIQDEELEPSTSSRMDRRIESEVS RLLWTAISSTAGPNLSSFSSTFSTPSPSFDSAPTSDGDVIVSSDPLSSPSTSSIANNAST SSAVKCNNVPESLAQMAAAARPTETAEVDKT----------------------------- ------------------------------------------------------------ ------LRLEEENKRLKDARECKICMADEVGVVFCP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVSCVQCAPAV---T NCPVCRAVIKGR---VRTFLS--------------------------------------- ----- >T_nigroviridis_ENSTNIP00000018867 ------------------------------------------------------------ -----------------------MEDQRHDNSNLETDS-AEDFSLIKSRLESFRGSSLVQ RVP-AERLARAGFYLVGPSDRVRCFSCQKTVENWSREDRPVERHKEVSPVCQFLSCIYGT RPH--------------------------------------------------------- ----QLIDASLANNSAYNEE-----------AVVDES----IYPVAPH-MKSEKSRLQTF S-SWP-----------------------------------------SAV--PVRPQDLAQ AGLYYLGQNDQV----------QCFCCGGILA--NWDAGDSAWGEHNKHFPSCFFILGHD V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN--------------------------------------- -----------------------IPLQGSGEEEKRVVPPA-------------------- GAG---AGVHMGTFEERLRSF-A---NV---QHPVNTERLARAGFYS-KG-TDAVLCFSC NGGLKGWRPEEDPWEEHARHYP-GC---RFLLTEKGQEFVNSIQLRVSGRNTA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VSQAVQDIQVF---KKIATVHFRVQVIRMDF Q---------------QQQWVHTHTKVHTDSSRQFFFKCETAAGQQNNRIFDIGVCPSCP PE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------DDPKKLLQKLQCEKMCKICLAKDICIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLIACEECSESL---V SCPVCCGGITQK---VKTFLTYPAKQ---------------------------------- ----- >D_rerio_ENSDARP00000013586 ------------------------------------------------------------ -------------FPPQRNLVTTNMAHSTHNGELESDNVAADWSVMKNRVNSFQRFPYSE DIS-AQRLARAGFYFTGEGDRVQCFSCSATVQNWNRGDTPLERHQLASPDCRFLSCAHGM RNS--------------------------------------------------------- ---------NSIQSPDYDEEAENREFLLRTGEVVDES----MYPVVPH-MKSEEARLSTF N-NWP-----------------------------------------ADS--PVRPEDLAE AGMYYIGIDDNV----------QCFCCGGGLS--GWEQGDDPWSEHAKYYSNCFFFLGHN V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN--------------------------------------- -----------------------VPLTTPRPRAN-------------------------- -------VHPTDTFEGRLDSF-K---GR---QHPIDPERLARAGFYS-TGEQDRVMCFRC GGGVKAWMPDEDPWEEHARHYP-GC---SFLLAEKGEEYVSSVQLRYPKRPTQ------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------NGFSSHESGSSA Q----------ALIHGSSDMFEKA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------DDPMTELEKLQREKLCKVCMDSDISIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCQKCSASL---D KCPICCATITQK---IKTYNA--------------------------------------- ----- >G_aculeatus_ENSGACP00000024474 ------------------------------------------------------------ -------------VPPSSILSSSIMCALRQDNQLESDH-MADFSEINNRLDSFRGSSLAQ QVP-AERLARAGFYYTGNADRVCCFSCEKTVENWCRGDTPLERHKEVSPSCIFLSCTQRT NFN--------------------------------------------------------- ----LSCENRLTNGFSYNEEEEDLEYRLRRGEVVDES----TYPMAPH-MKSEEARLQTL S-TWP-----------------------------------------SSS--PVRPRDLAQ AGLYYLGQSDRV----------QCFCCGGMLA--GWEVGDTAWEEHNKHFPNCFFMLGHD V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN--------------------------------------- -----------------------IPLHRGGVEEENSGRQ--------------------- HAS---ACVPMGSFEKRLGSF-A---GV---LHPIDHERLARAGFYS-AGTGDRVLCFRC GGGLKGWQPEEDPWEEHAKHYP-GC---SFLLTEKGQEYVNSIQLQDPRRNRT------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------NGFSGHGNGKKG A----------AVGHGSEGRWDD------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------VDPLEKLRELQREKLCKICMDRDIGIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCTKCSESL---I KCPICCGAITQK---IQTYIA--------------------------------------- ----- >O_latipes_ENSORLP00000012199 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MRRERERLQTF-Q---NWPD-EAPVTSEDLAKAGFYF-LGSEDKVKCFFC DGGLRNWEPGDDPWQEHAKWFP-RC---EFLIHSRGQDYINNIQDAHFHLGNS--GE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------KLLYLHFKLA -----------DMVGGLGAS-----------SA-MLSPVV---QTVLQMGFEDSLVQSLV Q----------TKYLLTGQHYTSVSDL--VTDVLQ--AEEEER----QRGANSRGS---- ------------------------------------------------------------ -----------------------------------AV----------------------- ------------------------------------------------------------ --KE--ASPEELLRQLQEERTCKVCMDKLVSIVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCGDCAASL---R HCPICRAVIRGS---VRAFMS--------------------------------------- ----- >C_intestinalis_ENSCINP00000002256 ------------------------------------------------------------ --------------------------------------------MESYRLSTFMKYPQDT PVN-PRHLAAAGFHYTGYKDRVKCFCCGLCVESWCVGDD-VKSPRWHRSNCEFILGQDCG ---NQPI-DHM-------------------------VWLQVVCSAT----LCDHLVQL-- ---GQG------------------------------------------------------ ---------------------------------------------------GIYSETLA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ GYV---TCPYMRNEESRFETFDH---RWPASNVRASPRQIAKAGFFF-LGDRDRVKCWYC NGGLQNWDPDDEPWTEHAKWFP-TC---EFLLQRKGPDFVHRMVSLYPNLPRP--IL--- RGPFDVPPRA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EVAKQ--QEQ-----VNKFMLGDLV---KSATEMGFETSVIRRVV T----------RRLTSGGNLYTSVADL--VDDITA--NENEPN----SDDDDETNASQPS QTTTVKTPD--------------------------------------------------- -----------------------------VT----------------------------- ------------------------------------------------------------ ------PSMEARIRELQEERKCKICLDKVADIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLCTCTECAEAL---R KCPICRSKIERG---IKTYMS--------------------------------------- ----- >G_gallus_ENSGALP00000009239 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MADTAPVEGTHLRATC--------- ------------------------------------------------------------ -----------------------------------------CHLFNYS-MRDEARRLRTF S-QWP-----------------------------------------RSS--PVSAWDLAK AGFFFVGPGDQV----------QCFSCGGILK--DWEPGDCPIVEHLKFFPFCKFIYHGA V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------WNQQ-VPLQGVFD---------------------------- --------------SVDGQILSLLQRIDSEETALP------------------------- NQP---EYPEMVTEEMRLSTF-Q---NWPQ-YTEMRPEQLARAGFFY-TGQGDVVRCFYC DGGMRNWAFGDDPWREHAKWYP-RC---EFLLRSMGREFVSSIFTDECL----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SKEESP----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LSTEEQLRRLQEERMCKVCMDRDVSVVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVACGECALNL---R LCPICRAVIQGS---VRTFMS--------------------------------------- ----- >T_guttata_ENSTGUP00000007779 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MGDAAPAQQPEPRAAR--------- ------------------------------------------------------------ -----------------------------------------RRLFEAS-MRSVARRLRTF Q-QWP-----------------------------------------RTA--PVSARDLVE AGFFYLGPGDEV----------QCFCCGGILK--DWRPGDCPMIEHLHFFPSCKYLSGED V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNQEMLSLQEIFD---------------------------- --------------TVDGQFLSVLQGIVSEETAQP------------------------- NEP---EYPEMVTEEMRLSTF-E---NWPQ-NSSMHPEQLARAGFFY-TGRGDVVRCFYC DGGVRSWSFGDDPWREHAKWYP-EC---EFLLHSRGREFVNSVQATFSI----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GKDESQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LSTEEQLRRLREERTCKVCMDKDVSVVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVACEECALNL---R LCPICRAGIQGR---VRAFMS--------------------------------------- ----- >M_domestica_ENSMODP00000021022 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VGPQDRV----------QCFCCGGMLD--NWMAGDSPILEHQRFFPKCQFALSKH T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN---IPA-QDTSD--------------------------- --------------SVDGQILSQLQRISEEGEGEGNEDTVT------------------- TRP---VYPDMGVEQIRLASF-H---NWPS-AAVVCPQQLARAGFFY-TGQHDHVKCYYC DGGLRNWDRGDDPWREHAKWFP-RC---EFLLQSRGRAYVNSIQDSS-SLLDS--WG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------HGEDPQ---- -----------EVAPTSTPA--SVP-----M----------------------------- -----------------------------ASESTP--PRRESQ----PEQITETDPLSVF LYLCS--LTLST------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GP--LSTEQQLQQLKEERTCKVCMYQVVSIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHL-VCSECAPNL---Q QCPICRAAIHGS---IRTFLS--------------------------------------- ----- >C_intestinalis_ENSCINP00000000487 ------------------------------------------------------------ --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------SIE-LFKEENRRETF K-TWS-----------------------------------------AAF-NDEFVKELAR SGFFYLGNLDRT----------QCFSCSGVLR--NWRASDDVNVEHFRHFPHCKMGSNSE S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KN-----VPLPLDH--------------------------- --------------PIDVDDIPEPPDPSPKEQENLVKMFTL------------------- GAP---MNPHMRSLDARVATFDR---RWPARKVKASATHIAKAGFYF-LGDRDRAKCWYC NGGLQNWDANDEPWVEHAKWFP-GC---EFVLRNKGIAFVHEIYTNNPNLNRP--EIQNA RSEYLTSPKK-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------NGGVMISQTATITAGD VLANYLPPPPPDGVERSPETGSATD-----VDAMMKNEVV---SVVTSMGFGHDLIRKAV E----------KHISNNGSNPPTTEGL--LELILQ--LDENDD----VIADDVINGDVMQ DD---------------------------IGAIGGIV---------ISQGEGVETKSSLK RNNDKAEQDSDQKP----------MKQQKFD----------------------------- ------------------------------------------------------------ ------TNAFEELESLEMERRCRACRNHVADTVVMP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLCFCSSCSSSS---K RCGLCREKIQSV---MKVYLS--------------------------------------- ----- >H_sapiens_ENSP00000321377 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MTGYEARLITF-G---TW---MYSVNKEQLARAGFYA-IGQEDKVQCFHC GGGLANWKPKEDPWEQHAKWYP-GC---KYLLEEKGHEYINNIHLTRS-LEGA--LV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------QTTKKT---- -----------PSL-TKRIS--DT---------IFPNPML---QEAIRMGFDFKDVKKIM E----------ERIQTSGSNYKTLEVL--VADLVS--AQKDTT----EN-ELNQTSL--- Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --RE--ISPEEPLRRLQEEKLCKICMDRHIAVVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCKQCAEAV---D RCPMCSAVIDFK---QRVFMS--------------------------------------- ----- >P_troglodytes_ENSPTRP00000019640 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MTGYEARLITF-G---TW---MYFVNKEQLARAGFYA-IGQEDKVQCFHC GGGLANWKPKEDPWEQHAKWYP-GC---KYLLEEKGHEYINNIHLTRS-LEGA--LV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------QTTKKT---- -----------PSL-TKRIN--DT---------IFPNPML---QEAIRMGFDFKDVKKIM E----------ERIQTSGSNYKTLEVL--VADLVS--AQKDTT----EN-ESNQTSL--- Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --RE--ISPEEPLRRLQDEKLCKICMDRHIAVVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCKQCAEAV---D RCPMCSAVIDFK---QRVFMS--------------------------------------- ----- >C_intestinalis_ENSCINP00000000510 ------------------------------------------------------------ --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------SIE-LFKEENRRETF K-TWS-----------------------------------------AAF-NDEFVKELAR SGFFYLGNLDRT----------QCFSCSGVLR--NWRASDDVNVEHFRHFPHCKMGSNSE S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KN-----VPLPLDH--------------------------- --------------PIDVDDIPVPPDPSPKEQEDLVKMFTL------------------- GAP---MNPHMRSLDARVATFDR---RWPARKVKASATHIAKAGFYF-LGDRDRAKCWYC NGGLQNWDANDEPWVEHAKWFP-GC---EFVLRNKGISFVHEIYTNNPNLNRP--EIQNA RSEYLTSPKK-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------NGGVMISQTATITAGE VLANYLPPPPPDGVERSPETGSATD-----VDAMMKNEVV---SVVTSMGFGHDLIRKAV E----------KHISNNGSNPPTTEGL--LELILQ--LDENHD----VIADDVINGDVMQ DD---------------------------IGAIGGIV---------ISQGEGVETKSSLK RNNDKAEQDSDQKP----------M----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >C_intestinalis_ENSCINP00000021651 --------------------------MLV------------------------------- ---------------DSFCSNLKYQTMFHNIDRVSQHAAAMDYSSKSNRIQSLENFP-SA PVN-PIQLAIHGFYFTGVEDCVVCFSCENSVRNWKLGDKEGDK-KWHKPDCVFFNSLSQT VND--------------------------------------------------------- -------------TNISTPNHQDMNHFVNTNPTEVVFET--MLLKRLT-HKSIKLNIRTF D-YWP-----------------------------------------HQL-REVNTAALAK YGFYYLGISDMV----------ECFCCSNVLG--NWNVDDNPKNRHLERFPNCRWVADVE V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------HQHPHL----------------------------------- ------------------------------------------------------------ LHP---HNAHMRSLEQRRSSFRG---FSPRHHLRATIDEIAEAGFYF-LGPGDLVKCWYC GNKLKNFDVEDEPWMEHAKWFP-QLSIPEFLLQNKGHAFVANIQTSYPRNVHV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------VNLPSVES----------GPTFLPSPIQ-------------------- -------------------NHETLSHEK-VDNISS--GQSNSN----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SQLCCKVCLNRDATIAFNP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLCVCQSCSPRL---N ACPICRRSIQQK---IRIYFP--------------------------------------- ----- >G_gorilla_ENSGGOP00000007398 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MTGYEAWLITF-G---TW---MYSVNKEQLARAGFYA-IGQEDKIQCFHC GGGLANWKPKEDPWXQXAKWYP-GC---KXLLEEKGHEYINNIHLTRS-LEGA--LV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------QTTKKT---- -----------PSL-TKRIS--DT---------IFPNPML---QEAIRMGFDFKDIKKIM E----------EKIQTSGSNYKTLEVL--XADLVS--XQKDTT----EN-ESNQTSL--- Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --RE--ISPXEPLRRLQEEKLCKICMDRHIAVVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVTCKQCAEAV---D RCPMCNAVIDFK---QRVFMS--------------------------------------- ----- >C_intestinalis_ENSCINP00000000466 ------------------------------------------------------------ ------MELANNLFSDIETDGMKVNTTSEPSDKRCVYITPGQKEREDYRITTFNKFPSNK PVD-KMKLSSNGFLYTGFKDRVKCFRCGQCVEGLNGTEN-MGLPGWHKPDCEFANGTDTT NVPLLRHKIQ-------------------------------------------------- -------------------------------------------------QNLPSLQNASF VQSIP-----------------------------------------NQDQTTLSAGELLK FGNIDQTTNQVV----------TPRNLPVQQSSNQFGQMYQTATIHKPHLQVPFSVLQST R----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ATEPAPRCAENSQFPC------------------- SNP---RNPHMKSERVRLQTFMNNLGKWSSHGIVTTPEQMADAGLFY-LSDRDRTKCWYC NGGLQNWEPNDDPWYEHAKWFP-EC---EFVLQQKGELYVHRIARQFPNLNRP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RISNPYQLFGRSNNDVPPPQ PQPQSPGPVIIDPQEEQRKLKSKI------DEEMESSAVV---DGAKQMGFEEKEIKRAI T----------KNMKENGKSFSTLLSL--VDAILADSDDDNTSSEEQSEAPTAPETTLTF NTDQ-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------QSTASELQRLEMARFCKICRQKEAVVVLLP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLSCCDTCGKKI---T KCPTCKLAVTDK---VHSFIA--------------------------------------- ----- >X_tropicalis_ENSXETP00000016315 ------------------------------------------------------------ ---------------------------------------------------------KHF PYQTSDKLAWAGFFYVGPGDRVRCFSCGGEVDNWEPGDVPLTRHQLFFPHCSYVQGLS-- ------------------------------------------------------------ ---------------------IRHSYFMEEGVGPGFLDTNILGKE--GDMSDEYSRIQSY Q-AVK-----------------------------------------EHF-PNQTPIKLAW AGFYYVGPKEKV----------RCFSCGGEMD--EWWSREDPLTEHHRRFPQCHFILGRK E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GN--------------PPGKG-------------------- ------------------------------------------------------------ SLP---SPRIFLCPRKCLEAQ-L---DFPCLLHHQTPIKLAWAGFYY-VGPKDKVQCFSC GGEMDKWWSREDPLTEHHRRFP-QC---HFILGRKAVSNDP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------YTMTEMLKGLNNQ----------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------Q SQPT-------------------------------------------------------- ----- >X_tropicalis_ENSXETP00000016312 ------------------------------------------------------------ ----------------------------YSGSQNPGEKPLGDMNDEYSRLETYRGHSQYF PMANQRKLAQAGFSYVGPGDRVRCISCGGELEKWERWDVPLTRHQHSFPHCPYMQKLRDE GDG--------------------------------------------------------- ----------KENQSKVCAGPIKEG---ESGTTVPLSSSSNLEKKPCGYMSDEYSRLESY R-GHGQHFNYWN----------------------------------QQRLAKQTSDELAW AGFFYVGPGDRV----------RCFSCGGEVD--NWEPGDVPLTGHQLFFPHCSYVQGLS I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------RHSYFMEEGVGPGF--------------------------- ------------------------------------------------------------ ------LDTNILGN--RIQSY-Q---AVKEHFPNQTPIKLAWAGFYY-VGPKDKVQCFSC GGEMDKWWSREDPLTEHHRRFP-QC---HFILGRKAVSNDP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------YTMTEMLKGLNNQ----------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------Q SQPT-------------------------------------------------------- ----- >M_musculus_ENSMUSP00000112867 ----------------------------------------------MAEHGESSEDRISE IDYEFLAELSARFGMNLVQLAKSQEEEDHKERMKMKKGFNSQMRSEAKRLKTFESYDTFR SWT-PQEMAAAGFYHTGVKLGVQCFCCSLILFGNSLRKLPIERHKKLRPECEFLQGKDVG NIG--------------------------------------------------------- -----------------------------KYDIRVKSPEKML-RGGKARYHEEEARLESF E-DWP-----------------------------------------FYA-HGTSPRALSA AGFVFTGKRDTV----------QCFSCGGSLG--NWEEGDDPWKEHAKWFPKCEFLQSKK S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SEEIAQYIQDYEGFVHVTGEHFVKSWVRRELPMVS AYC---NDSVFTNEELRMDMF-K---DWPQ-ESPVGFEALVRAGFFY-TGKKDIVRCFSC GGCLEKWAEGDDPMEDHIKFFP-EC---VFLQTLKSSAEVIPTLQSQYALPEATETTRES NHDDAAAVHSTVV--------------------------------------------DLG RSEAQWFQEARSLSEQLRDTYTKTSFCHMNLPEVCSSLGTDHLLGCDVSIISKHVSQPVQ GALTIPEVFSNLSSVMCVEGEAGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSIT PDQGLANIICTQLLGAGGCISEVCLSSSIQQLQHQVLFLLDDYSGLASLPQALHTLITKN YLFRTCLLIAVHTNRVRDIRPYLGTSLEIQEFPFYNTVFVLRKFFSHDIICVEKLIIYFS ENKDLQGVYKTPLFVAAVCNDWNQNASAQDDFQDVTLFHSYMQYLSLKYKATAESLQATV SSCGQLALTGLFSSCFEFNSDDLAEAGVDEDVKLTTFLMSKFTAQRLRPVYRFLGPLFQE FLAAVRLTELLSSDRQEDQDLGLYYLRQIDSPLKAINSFNIFLYYVSSHSSSKAAPTVVS HLLQLVDEKESLENMSENEDYMKLHPQTFLWFQFVRGLWLVSPESFSSFVSEHLLRLALI FAYESNTVAECSPFILQFLRGRTLALRVLNLEYFWDHPESLLLLRSLKVSINGNKMSSYV DYS-FKTYFENLQPPAINEEYTSAFEH--VSEWRRNFAQDEEIIKNYENIWPRALPDISE GYWNLSPKPCKIPKLEVQVNNMGPADQALLQVLMEVFSASQSIEFHLFNSSGFLESIRPA LELSKASVTKCSMSRLELSRAEQELLLTLPALQSLEVSETNQLPDQLFHNLHKFLGLKEL CVRLDGKPDVLSVLPEEFLNLHHMEKLSIRTSTESDLSKLVKFIQNFPNLHVFHLKCDFL SNCESLMTALASCKKLREIEFSGQCFEAMTFVNILPNFVSLKILSLKGQQFADKETSEKF AQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLPCLRVLAFHDILDDESVIEIARAAT S-GSFQKLENLDISMNHKITEEGYRNFFQALDNLPNLQMLNICRNIPGRIQVQATT--VK ALGHCVSRLPSL---TRLGMLSWLLDEEDMKVINDVKERHPQSKRLTIFWKWIVPFSPVV LE--- >G_gorilla_ENSGGOP00000008152 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MGPKDSA----------KCLHRGPQPS--HWAAGDGPTQERGGPRSLGSPVLGLD T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CRAWD--------------------------- --------------HVDGQILGQLRPLTEEEEEEGAGATLS------------------- RGP---AFPGMGSEELRLASF-Y---DWPL-TAEVPPELLAAAGFFH-TGHQDKVRCFFC YGGLQSWKRGDDPWTEHAKWFP-SC---QFLLRSKGRDFVHSVQETHSQLLGS--WD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------PWEEPE---- -----------DAAPVAPSV--PAS-----G----------------------------- -----------------------------YPELPT--PRREVQ----SESAQEPGGVSPA QAQRAWWVLEPP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GA--RDVEEQLRRLQEERTCKVCLDRAVSIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHL-VCAECAPSL---Q LCPICRAPVRSR---VRTFLS--------------------------------------- ----- >M_musculus_ENSMUSP00000058611 ----------------------------------------------MAEHGESSEDRISE IDYEFLPELSALLGVDAFQVAKSQEEEEHKERMKMKKGFNSQMRSEAKRLKTFETYDTFR SWT-PQEMAAAGFYHTGVRLGVQCFCCSLILFGNSLRKLPIERHKKLRPECEFLQGKDVG NIG--------------------------------------------------------- -----------------------------KYDIRVKRPEKML-RGGKARYHEEEARLESF E-DWP-----------------------------------------FYA-HGTSPRVLSA AGFVFTGKRDTV----------QCFSCGGSLG--NWEEGDDPWKEHAKWFPKCEFLQSKK S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SEEIAQYIQSYEGFVHVTGEHFVKSWVRRELPMVS AYC---NDSVFANEELRMDMF-K---DWPQ-ESPVGVEALVRAGFFY-TGKKDIVRCFSC GGCLEKWAEGDDPMEDHIKFFP-EC---VFLQTLKSSAEVIPTLQSQYALPEATETTRES NHGDAAAVHSTVV--------------------------------------------DLG RSEAQWFQEARSLSEQLRDNYTKATFRHMNLPEVCSSLGTDHLLSCDVSIISKHISQPVQ EALTIPEVFSNLNSVMCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSIT PDQGLANIICAQLLGAGGCISEVCLSSSIQQLQHQVLFLLDDYSGLASLPQALHTLITKN YLSRTCLLIAVHTNRVRDIRLYLGTSLEIQEFPFYNTVSVLRKFFSHDIICVEKLIIYFI DNKDLQGVYKTPLFVAAVCTDWIQNASAQDKFQDVTLFQSYMQYLSLKYKATAEPLQATV SSCGQLALTGLFSSCFEFNSDDLAEAGVDEDEKLTTLLMSKFTAQRLRPVYRFLGPLFQE FLAAVRLTELLSSDRQEDQDLGLYYLRQIDSPLKAINSFNIFLYYVSSHSSSKAAPTVVS HLLQLVDEKESLENMSENEDYMKLHPQTFLWFQFVRGLWLVSPESSSSFVSEHLLRLALI FAYESNTVAECSPFILQFLRGKTLALRVLNLQYFRDHPESLLLLRSLKVSINGNKMSSYV DYS-FKTYFENLQPPAIDEEYTSAFEH--ISEWRRNFAQDEEIIKNYENIRPRALPDISE GYWKLSPKPCKIPKLEVQVNNTDAADQALLQVLMEVFSASQSIEFRLFNSSGFLESICPA LELSKASVTKCSMSRLELSRAEQELLLTLPALQSLEVSETNQLPEQLFHNLHKFLGLKEL CVRLDGKPNVLSVLPREFPNLLHMEKLSIQTSTESDLSKLVKFIQNFPNLHVFHLKCDFL SNCESLMAVLASCKKLREIEFSGRCFEAMTFVNILPNFVSLKILNLKDQQFPDKETSEKF AQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLPCLRVLTFHDILDDDSVIEIARAAT S-GGFQKLENLDISMNHKITEEGYRNFFQALDNLPNLQELNICRNIPGRIQVQATT--VK ALGQCVSRLPSL---IRLHMLSWLLDEEDMKVINDVKERHPQSKRLIIFWKLIVPFSPVI LE--- >C_intestinalis_ENSCINP00000020067 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MAEIDRQDITGLASPSLTQHKEAKTQIL P----------------------------------------------------------- --GRNCCASNSV----------TAFDC--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ KHP---YTKNMENFRERIRTF-I---SWPRGVTKATPVEIAKAGFFY-LKERDRAKCFYC NGGLQNWEPNDEPWFEHAKWFP-NC---DFLLREKGIEFVQNVAGRFPNLNRP--LL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------NDQATPKPST SNLQLPAPATSKQTEVPQNSASHIEITRPTLEEAMESELV---LAVSGFGFERELVQLVV E----------RLLQETGNVNCTIMEL--VTATQQ--LEQKQM----EENAMEVVESFNV N------------------------------------------------QEKPEMACAQI NLSTSPTDSFPMQTPGNFTEQQVPGSKKMMYVKQKEVSVPELS----------------- ------------------------------------------------------------ --EQSLAQQRSQLQNLKDEMRCKICLDNPMDCILLE------------------------ ------------------------------------------------------------ ------------------------------------------CGHVCTCLECSQGI---R TCPICRQKITKI---MKIYRNY-------------------------------------- ----- >M_musculus_ENSMUSP00000022142 ----------------------------------------------MAEHGESSEDRISE IDYEFLPELSALLGVDAVQLAKSQEEEEHKERMKMKKGFNSQMRSEAKRLKTFETYDTFR SWT-PQEMAAAGFYHTGVKLGVQCFCCSLILFGNSLRKLPIERHKKLRPECEFLQGKDVG NIG--------------------------------------------------------- -----------------------------KYDIRVKSPEKML-RGGKARYHEEEARLESF E-DWP-----------------------------------------FYA-HGTSPRVLSA AGFVFTGKRDTV----------QCFSCGGSLG--NWEEGDDPWKEHAKWFPKCEFLQSKK S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SEEIAQYIQGYEGFVHVTGEHFVNSWVRRELPMVS AYC---NDSVFANEELRMDTF-K---DWPH-ESPVAVDALVRAGLFY-TGKKGIVQCFSC GGCMEKCTEGDDPIQEHNKFFP-NC---VFLQTPKSSAEVIPALQSHCALPEAMETTSES NHDDPAAVHSTVV--------------------------------------------GLG RSEAQWFQEARSLSEQLRDNYTKATFRHMNLPEVCSSLGTDHLIGCDVSIISKHISQPVQ GALTIPEVFSNLSSVMCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSIT PDQGLANIICAQLLGAGGCISEVCLSSIIQQLQHQVLFLLDDYSGLASLPQALHTLITKN YLSRTCLLIAVHTNRVRGIRSYLDTSLEIKEFPLSNTVYILKKFFSHNIKRLLEFMVYFG QNEDLQGIHKTPLFVAAVCTDWFENPSDQ-PFQDMALFKSYMQYLSLKHKGAAKPLQATV SSCGQLALTGLFSSCFEFNSDDLAEAGVDEDEELTTCLMSKFTAQRLRPVYRFLGPLFQE FLAAMRLTELLSSDRQEDQDLGLYYLRQINSPLKALTTYNNFLKYVFSHPSSKAGPTVVS HLLHLVDETELLENTYKNEDYVNHPPGTSRIMKGLKELWLLSPEYYSSFVSEHLLRIALN FAYESNTVAECSPFILQFLRGRTLALKVLNLQYFRDHPESLLLVKSLEVSINGNKVPKVV DYSVMEKSFETLQPPTIDQDYASAFEQ--MKEHEKNLSENEETIKSIKNIFPLQPPKISS GYWKLSPKPCKIPRLEVGVTNMGPADQALLQVLMEVFSASQSIEFRLSDSSGFLESIRPA LELSKASVTKCSMSRLELSRAEQELLLTLPALQSLEVSETNQLPDQLFHNLHKFLGLKEL CVRLDGKPDVLSVLPGEFPNLLHMEKLSIRTSMESDLSKLVKLIQNSPNLHVFHLKCDFL SNCDSLMAVLASCKKLREIEFSGRCFEAMPFVNILPNFISLKILNLISQQFPDKETSEKF AQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLPCLRVLAFHYILDNDSVIEIARVAT S-GGFQKLEKLDLSMNHKITEEGYRNFFQALDNLPNLQNLNICRHIPECIQVQATT--VK ALGQCVSRLPSL---TRLHMLSWLLDEEDMKVINDVKERHPQSKRLIIFWKWIVPFSPVV LE--- >X_tropicalis_ENSXETP00000057704 ------------------------------------------------------------ ------------------------------------------------------------ ----QNKLANAGFYYVGPEDRVRCFSCGGQFEMWEEWDFPLTRHQQTFPECPYLQELKAK GEW--------------------------------------------------------- ----------------------------KDCHYEPGLGSNILMEKPLGDLSDERRRLETF R-GHSGLFPYNRVKFLAIQSPNILGKKSHYDMTNMYSRADTYRGHHKHFLPYMKEWDLAQ AGFYYVGPGDRV----------RCISCGGELE--KWERWDVPLTRHQHSFPHCPYMQKLR D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EGDGGTV-------------------- ------SILYIGTNRAWLRQVST---MWGP-RTGSRENKLANAGFYY-VGPRDRVRCFSC GGQLEMWEEWDFPLTRHQQTFP-EC---PYLQELKAKGEWQLIMMAQAGF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >H_sapiens_ENSP00000217169 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MGPKDSA----------KCLHRGPQPS--HWAAGDGPTQERCGPRSLGSPVLGLD T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CRAWD--------------------------- --------------HVDGQILGQLRPLTEEEEEEGAGATLS------------------- RGP---AFPGMGSEELRLASF-Y---DWPL-TAEVPPELLAAAGFFH-TGHQDKVRCFFC YGGLQSWKRGDDPWTEHAKWFP-SC---QFLLRSKGRDFVHSVQETHSQLLGS--WD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------PWEEPE---- -----------DAAPVAPSV--PAS-----G----------------------------- -----------------------------YPELPT--PRREVQ----SESAQEPGGVSPA EAQRAWWVLEPP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GA--RDVEAQLRRLQEERTCKVCLDRAVSIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHL-VCAECAPGL---Q LCPICRAPVRSR---VRTFLS--------------------------------------- ----- >P_troglodytes_ENSPTRP00000023641 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------LGLD T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CRAWD--------------------------- --------------HVDGQILGQLRPLTEEEEEEGAGATLS------------------- RGP---AFPGMGSEELRLASF-Y---DWPL-TAEVPPELLAAAGFFH-TGHQDKVRCFFC HGGLQSWKRGDDPWTEHAKWFP-SC---QFLLRSKGRDFVHSVQETHSQLLGS--WD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------PWEEPE---- -----------DAAPVAPSV--PAS-----G----------------------------- -----------------------------YPELPT--PRREVQ----SESAQEPGGVSPA QAQRAWWVLEPP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GA--GDVEAQLRRLQEERTCKVCLDHAVSIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHL-VCAECAPGL---Q LCPICRAPVRSH---VRTFLS--------------------------------------- ----- >X_tropicalis_ENSXETP00000034890 ------------------------------------------------------------ ---------------------------------------------------------KHF PYMKEWDLAQAGFYYVGPGDRVRCISCNAELEKWEKWDEPLTRHQHSFPDCAYVQEQRAQ TTG--------------------------------------------------------- ----------TQDQSQVCPMPIKEG---ESGIPARYSGSHNPGEKPLGDMNDEYSRLETY R-GHS-----------------------------------------QYF-PMANQRRLAQ AGFSYVGPGDQV----------RCFSCGGELE--KWERWDVPLTRHQHSFPHCHYIYGRK T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GY-------IGIPLLRPLGEV-------------------- ------------------------------------------------------------ ------SETQLLYGRRSWTGF-S---GHQHPREDQTPIKLAWAGFYY-VGPKDKVRCFSC GGEMDEWWSREDPLTEHHRKFP-QC---HFILGRKAVSNDP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------YTMTEMLKGLNNQ----------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------Q SQPT-------------------------------------------------------- ----- >B_taurus_ENSBTAP00000004317 ----------------------------------------------MATQEKAPEERISQ FDYALLPEMSAFLGVNALQFVKEIEEKEHRDREKMQKGFNSQMRSEAKRLKTFVTYNTFR SWT-SQEMAEAGFYLTGTKSGIQCFCCSLILFGTSLQNTPMEHHKKFHPDCEFLLGKDVG NIA--------------------------------------------------------- -----------------------------KYDVRVQKPENTLRRDDKARYQEEKARLESF K-NWP-----------------------------------------FYA-QGTSPRELSA AGFVFTGKHDTV----------QCFSCGGCLG--NWEDDDDPWKEHAKWFPKCEFLQSKK S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------LEEITQYIQSYKGFVDVTGEHFLNSWVKRDLSVAS VCCNGSNSSSFVNEELLLQSF-K---SWHP-SYPVGAAALAKAGFFY-TGKSDIVQCYSC GGYLHDWKEGDDPLEEHAKFFP-NC---QFLQSVKSSAEAIPDLQSHDELSELTETTNEG NLEESTAVSSIVP--------------------------------------------EVA QGEAQWFQEAESLSEHLRKVYTSAPFCHMSLLEISSCLATDQWLDCDLSFALKHITNPVQ EPVVLPEVFANLNSVMCVEGEAGSGKTILLKKIAHLWASGRCPLLNRFRLVFCLSLGSTR PEQGLASVIRDQLLETKLSVTEMGLRNIIQQLKNQVLFLLDDYKEMCSVPQVIARMIQKK HLSRTCLVITVRTNRAKNIRRYLDTIIEIKAFPFYNTISILRKLFPGDLTRLRKLMVDFG MNQTWQGIQKTPLFVAAVRASWLQNRFHR-SFDSVAVFESYMECLFLKHKTEADLLKATV SSCGDLALKGFFSSCFEFSDEDLIEAGIGEEEDLAMYLMSKFTAQRLRPVYQFLNPAFQE FLAGMRLTELLDSDRQEDQDLGLHYLKRINSTLMVIYPYANFLNCVSRHPSTKAGPKIVS HLLLLVDNKETLENISENDDYLKHHPEISEVMQFFRLIWQLSPQNYLSLASKHLLALAIR IAYQSNTVAACSPFILQFLRGRTLCLDVLKLQYFFDHPESLLLLRSIQVSINGNRLFKTD T--PLERIFDKSQAPTIEQDYASAFEL--ESEWKQSLDEKHEIIQNFQNMRLNAPPAINT GYWNLPSKQYKIPLLEVHVTNTHAVDQEMLRFLTEVFSAAQHIELHLNHSRGFIENIRPA LEQFRASFTKCCISQCELSAIEQELLLTLTSLESLEVSETTHPQDQLFLSLDKFLCLKEL SVNL--QQDVFSAISEEFLNLHHMEKLLIQISSKCSPSKLVRLVQNSPNLQVFHLECNSF SDFESLVTALASRKKLEEIKFSGQFFQANPFVIVLPNFTSLKILKLGIQYIPDKETAEKF AYALGSLNNLEELILPTGDGIHQMAKLIIQQCQHLQCLQVLQFFKTLDDDSVVEIAKVAI N-GGFQKLKHLDFSMNHKITEEGYRNFFQTLDNLPSLQELTISRHFKECIKVQAAT--VK SLSQCVLRLPSL---LRLNMLSWLLDAEDITLLTATIKKHPQSKHFILSWKWILPFSPII QEPIS >M_mulatta_ENSMMUP00000012096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MGPEDSA----------KCPRHGPQLC--RWAAGDGPARERCGPRSLGSPALGLD S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CRAWD--------------------------- --------------HVDGQILGQLRPLAEEEEEEGAGAMSP------------------- RGP---AFPGMGSEELRLASF-Y---DWPL-TAGVPPELLAAAGFFH-TGQQDKVRCFFC YGGLQSWKRGDDPWTEHAKWFP-SC---QFLLRSKGRDFVHSVQETHSQLLGS--WD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------PWEEPE---- -----------DAAPVAPSV--PAP-----G----------------------------- -----------------------------DPELPT--PRREVQ----SESAQEPGGASPA QAQSGWWVLEPP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GA--RDVEEQLRRLQEERTCKVCLDRAVSIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHL-VCAECAPSL---Q LCPICRAPVRSR---VRTFLS--------------------------------------- ----- >P_troglodytes_ENSPTRP00000048273 ----------------------------------------------MATQQKASDERISQ FDHNLLPELSALLGLDAGQLAKELEEKEQKERAKMQKGYNSQMRSEAKRLKTFVTYEPYS SWI-PQEMAASGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKRFHPDCGFLLNKDVG NIA--------------------------------------------------------- -----------------------------KYDIRVKNLKSRL-RGGKMRYQEEEARLASF R-NWP-----------------------------------------FYV-QGISPCVLSE AGFVFTGKQDTV----------QCFSCGGCLG--NWEEGDDPWKEHAKWFPKCEFLRSKK S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SEEITQYIQSYKGFVDITGEHFVNSWVHRELPMAS AYC---NDSIFAYEELRLDSF-K---DWPR-ESAVGVAALAKAGLFY-TGIKDIVQCFSC GGCLEKWQEGDDPLDDHTRWFP-NC---PFLQNMKSSVEVTPDLQSRGEPCELLETTSES NLEDSIAVDHIVP--------------------------------------------EMA QGEARWFQEAKNLNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQ EPLVLPEVFANLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTR PDEGLASIICDQLLEKEGSVTEMCMRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKN HLSRTCLLIAVRTDRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFG KNQSLQKIQKTPLFVAAICAHWFQYPFDP-SFDDVAVFKSYMERLSLRNKATAEILKATV SSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQE FLAGMRLIELLDSDRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVS HLLHLVDNKESLENISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLALK IAYQSNTVAACSPFVLQFLQGRTLTLGVLNLQYFFDHPESLSLLRSIHFSIRGNKTSPRA HFSVLETCFDKSQVPTIDQDYASAFEP--MNEWERNLAEKEDNVKSYMDMQRRASPDLST GYWKLSPKQYKIPCLEVNVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPA LELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKEL SVDLEGNINVFSVIPEEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSPNLHVFHLKCNFF SDFESLMTMLVSCKKLTEIKFLDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKF AYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAI S-GGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLKELDISRHFTECIKAQATT--VK SLSQCVLRLPRL---IRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPII QK--- >M_musculus_ENSMUSP00000113890 ----------------------------------------------MAAQGEAVEEIICE FDDDLVSELSTLLRVDALSVLKRQQEEDHKTRMKMKKGFNSQMRSEAKRLKTFETYDKFR SWT-PQEMAAAGFYHTGVKLGVQCFCCSLILFSTRLRKLPIENHKKLRPECEFLLGKDVG NIG--------------------------------------------------------- -----------------------------KYDIRVKSPEKML-RGDKARYHEEEARLESF E-DWP-----------------------------------------FYA-HGTSPRVLSA AGFVFTGKRDTV----------QCFSCGGCLG--NWEEGDDPWKEHAKWFPKCEFLQSKK S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------PEEITQYVQSYEGFLHVTGEHFVNSWVRRELPMVS AYC---NDSVFANEELRMDTF-K---DWPH-ESPGAVEALVKAGLFY-TGKRDIVQCFSC GGCMEKWAEGDNPIEDHTKFFP-NC---VFLQTLKSSAEVIPALQSHCALPEAMETTSES NHDDAAAVHSTVVDVSPSEAQELEPASSLVSVLCRDQDHSEAQGRGCASSGTYLPSTDLG QSEAQWLQEARSLSEQLRDTYTKATFRHMNLPEVYSSLGTDHLLSCDVSIISKHISQPVQ GSLTIPEVFSNLNSVMCVEGEAGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSIT PGQELAKIICAQLLGAGGCISEVCLSSIIQQLQHQVLFLLDDYSGLASLPQALHTLITKN YLSRTCLLIAVHTNKVRGIRPYLDTSLEIKEFPFYNTVSVLRKLFSHDIMRVRKFINYFG FHEELQGIHKTPLFVAAVCTDWFKNPSDQ-PFQDVALFKAYMQYLSLKHKGAAKPLQATV SSCGQLALTGLFSSCFEFNSDNLAEAGVDEDEELTTCLMSKFTAQRLRPVYRFLGPLFQE FLAAVRLTELLSSDRQEDQDLGLYYLRQINSPLKAMSIYHTFLKYVSSHPSSKAAPTVVS HLLQLVDEKESLENMSENEDYMKLHPEALLWIECLRGLWQLSPESFSLFISENLLRICLN FAHESNTVAACSPVILQFLRGRTLDLKVLSLQYFWDHPETLLLLKSIKISLNGNNWVQRI DFSLIEKSFEKVQPPTIDQDYAIAFQP--INEVQKNLSEKKHIIKKYEDMKHQIPLNIST GYWKLSPKPYKIPKLEVQVTNTGPADQALLQVLMEVFSASQSIEFRLSDSSGFLESIRPA LELSKASVTKCSMSRLELSREDQKLLLTLPTLQSLEVSETNQLPDQLFHNLHKFLGLKEL CVRLDSKPDVLSVLPGEFPNLHHMEKLSIRTSTESDLSKLVKLIQNSPNLHVFHLKCNFL SNCEPLMTVLASCKKLREIEFSGRCFEAMTFVNILPNFVFLKILNLRDQQFPDKETSEKF AQALGSLRNLEKLFVPTGDGIHQVAKLIVRQCLQLPCLRVLVFAETLDDDSVLEIAKGAT R-GGFQKLENLDLTLNHKITEEGYRNFFQVLDNLPNLKNLDISRHIPECIQIQAIT--VK ALGQCVSRLPSL---TRLGMLSWLLDEEDIKVINDVKERHPQSKRLTVHWRWVVPFSPVI QK--- >R_norvegicus_ENSRNOP00000024483 ----------------------------------------------MAEHGEASEDQVSE FDGECLPELSALLGVDAVQLVKSQEEEENKERMKMKKGFNAQMRSEAKRLKTFVTYDAFK SWT-PQEMAAAGFYYTGVRHGVQCFCCSLILFGTSLRKVPIESHRKLRPQCEFLSGKDVG NIG--------------------------------------------------------- -----------------------------KYDIRVKNPETLP-RGGRARYHEEEARLESF E-DWP-----------------------------------------FYA-HGTSPRVLSA AGFVFTGKRDTV----------QCFSCGGCLG--NWEEGDDPWKEHAKWFPKCEFLQSKK S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TEEINQYIQSYTGFLHVAGEHFVNSWVRRELPVVS AYS---NDSVFANEGLRMDTF-K---DWPH-ESSVAVEALVKAGLFY-TGKKDIVQCFSC GGCMENWKEGDDPIEDHTKFFP-NC---VFLQTLKSSAEVIPALQSHCACPEAMETTSES NHEDPVAVHSSVA--------------------------------------------GLG QSEAQWCQEARSLSEQLRGTYTKASFRHMNLPEAYSSLGTDHLLGCEVFLISKHVSRPVQ VALTIPEVFANLSSVMCVEGEAGSGKTTFLKRIAFLWASGCCPLLNRFQLVFYLSLRSIR ADQGLADIICAQLLEAGGCISEVSLSSGIQHLQHQVLFLLDDYSGMDSLPQALDTLITKN YLSRTCLLMAVHTNRVRDIRPYLETVLQIKEFPFYNTISVLRKFFSHNTTRLLEFMVYFG RNEDLQGVHKTPLFVAAVCTDWFQNPSDQ-PFQDVTIFKSYMQYLFLKHKATAGPLQATV SSCGHLALTGLFSSSFEFSSDDLIEAGVDEDEELSTCLMSKFTAQRLRPVYRFLSPLFQE FLAAMRLSELLGSDSQEDQDLGLYYLRQINSPLKAINSYGIFLKYVSDHCSSKAGPKVVS HLLQLVDEKESLENMSENEDYMKLHPETFLWLHFLRGLWLNSPESFSSLLSERLLNIALN FAYQSSTVAACSPVILQFLRGRTLALGVLNSQYFWDHPESLLLLGSLKVSINGNEISSHV DYS-FKTYFENLQPPAIDKEYTSAFEH--ISEWKRNFAEDEKIIKHYQNIWPRVLPDISE GYWKLSPKPYKIPRLEVGVNNMGPADQALLHVLMEVFSASQSIEFQLFNSSGFLESIRPA LELNKTSVTKCSMSRLELSRAEQELLLTLPALQSLEVSETNQIPDQLFHNLDKFLGLKEL SVRLDGTQDVLSVLPGEFPNLHHMEKLSIHTFTESDLSKLVKLIQNSPNLHDIHLKCDFL SNCESLMAALASCEKLREIEFSGRCFEAMPFVTLLPNFVFLKILNLKGQQFPDKETSEMF AQALGSLRKLEELHLPKGDGIHQVAKLIVQQCLQLPCLRVLAFHHVLDDDSVTEVARVAT S-RGFQKLENLDLSMNHKITEEGYRNFFQALDNLPNLQELNICRHIRECIQVQAST--VK ALGQCVSRLPSL---TRLRMLSWLLDEEDMKVINDVKERHPQSKRLTVFWKWIVPFSPVV QE--- >H_sapiens_ENSP00000194097 ----------------------------------------------MATQQKASDERISQ FDHNLLPELSALLGLDAVQLAKELEEEEQKERAKMQKGYNSQMRSEAKRLKTFVTYEPYS SWI-PQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKRFHPDCGFLLNKDVG NIA--------------------------------------------------------- -----------------------------KYDIRVKNLKSRL-RGGKMRYQEEEARLASF R-NWP-----------------------------------------FYV-QGISPCVLSE AGFVFTGKQDTV----------QCFSCGGCLG--NWEEGDDPWKEHAKWFPKCEFLRSKK S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SEEITQYIQSYKGFVDITGEHFVNSWVQRELPMAS AYC---NDSIFAYEELRLDSF-K---DWPR-ESAVGVAALAKAGLFY-TGIKDIVQCFSC GGCLEKWQEGDDPLDDHTRCFP-NC---PFLQNMKSSAEVTPDLQSRGELCELLETTSES NLEDSIAVGPIVP--------------------------------------------EMA QGEAQWFQEAKNLNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQ EPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTR PDEGLASIICDQLLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKN HLSRTCLLIAVRTNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFG KNQSLQKIQKTPLFVAAICAHWFQYPFDP-SFDDVAVFKSYMERLSLRNKATAEILKATV SSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQE FLAGMRLIELLDSDRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVS HLLHLVDNKESLENISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLALK TAYQSNTVAACSPFVLQFLQGRTLTLGALNLQYFFDHPESLSLLRSIHFPIRGNKTSPRA HFSVLETCFDKSQVPTIDQDYASAFEP--MNEWERNLAEKEDNVKSYMDMQRRASPDLST GYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPA LELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKEL SVDLEGNINVFSVIPEEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSPNLHVFHLKCNFF SDFGSLMTMLVSCKKLTEIKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKF AYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAI S-GGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQATT--VK SLSQCVLRLPRL---IRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPII QK--- >C_intestinalis_ENSCINP00000010449 ------------------------------------------------------------ ---MQARMMDIRCDGLRVVHNDGRLVPSATNSERELYTRPGDPYYESYRLATFTNYP-NQ NIN-VRQVARAGFYFISYQDQVKCFSCGQICEDLQQYDD-MSLPQWHLPDCEHLHSLQPN RNNHANTPVQS------------------------------------------------- ---------------------------------GLSRPNENATFRSLPTRRPAHSNVHSS S-SLP------------------------------------------RQPTTITINQPRI RSTFTIHEHSNI----------DLFPC--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ NRP---ESPHMRSVEQRLQTFTRS--NWPAHRVRASILDISRAGLFY-LGNSDRTKCWYC NGGLQNWEPNDDPWYEHAKWFP-EC---EFLLQQKGIEYVYRVSSQFPNLQRP--VIVRS QPQPSVTIHI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------NRPGRTTMPTASTTHTTSSTTRISAPRSTVVSGPQFLP PMIPGPSINIIDPREQPRSREEEL------NRYITTSPYI---AVARGMGFDDEAIRSTL R----------RQHEQSQRFFSSAEEL--VDALLNQSNI--------TSAPQIPSSSTAG ATGGP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------ITPLEELRQLEQSRMCKVCHRNQANMVLLP------------------------ ------------------------------------------------------------ ------------------------------------------CGHVACCTTCGNDV---T NCPVCLADITDR---VRSYIG--------------------------------------- ----- >M_musculus_ENSMUSP00000104503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MFSPADLFR AAVFSMGPESRA----------RDSVRGPELS--HREDGSGRTQEQDKPHCPCNHVLGQD C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------LDGQILGQLRPLSEEEESSGAAFL--------------------- GEP---AFPEMDSEDLRLASF-Y---DWPS-TAGIQPEPLAAAGFFH-TGQQDKVRCFFC YGGLQSWERGDDPWTEHARWFP-RC---QFLLRSKGRDFVERIQTYTP-LLGS--WD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------QREEPE---- -----------DAVSATPSA--PAH-----G----------------------------- -----------------------------SPELLR--SRRETQ----PEDVSEP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GA--KDVQEQLRQLQEERRCKVCLDRAVSIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHF-VCTECAPNL---Q LCPICRVPICSC---VRTFLS--------------------------------------- ----- >P_pygmaeus_ENSPPYP00000017359 ----------------------------------------------MATQQKASDERISQ FDHDLLPELSALLGLDAVQFVKEIEEEEQKERAKMQKGYNSQMRSEAKRLKTFVTYEPYS SWI-PQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKRFHPDCGFLLNKDVG NIA--------------------------------------------------------- -----------------------------KYDIRVKNLKSRL-RGGKMRYQEEEARLASF K-NWP-----------------------------------------FYV-QGIPPCVLSE AGFVFTGKQDTV----------QCFSCGGCLG--NWEEGDDPWKEHAKWFPKCEFLQSKK S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SEEITQYIQSYQGFVDITGEHFVNSWVQRELPMAS AYC---NDSIFAYEELRLDSF-K---DWPR-ESAVGVAALAKAGLFY-TGIKDIFQCFSC GGCLEKWQEGDDPLDNHTRCFP-NC---PFLQNMKSSAEVIPDLQSHGELCELLETTSES NPEDSIAVDPIVP--------------------------------------------EMA QGEAQWFQEAKNLNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQ EPLVLPEVFANLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSFSSTR PDQGLASIICDQLLEKEGSVTEMCMRNILQQLKNQVLFLLDDYKEICSIPQVIGKLIQKN HLSRACLLIAVRTDKARDIRRYLETILEIKAFPFYNTVFILRKLFSHNMTRLRKFMVYFG KNQSLQKIQKTPLFVAAICAHWFQYPFDP-SFDDVAVFKSYMERLFLRNKATAELLKATV SSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQE FLAGMRLIELLESDRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVS HLLHLVDNKESLENISENDDYLKHQPEISLKMQLLRGLWQICPQAYFSMVSEHLLVLALK IAYQSNTVAVCSPFVLQFLQGRTLTLGALNLQYFFDHPESLSLLRSIHFSIQGNKTSPRA HFSVLETCFDKSQVPTIDQDYASAFEP--MNEWERNLAEKEDDVKSYMDMQRRASPDLST GYWKLSPKQYKIPCLKVNVNDIDAVDHEMLEILMTVFSASQRIELHLNHSRGFIESIRPA LELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKEL SVDLEGKINVFSVIPEEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSPNLHVFHLKCNFF SDFESLMTILASCKKLTEIKFLDSFFQPVPFVAILPNFISLKILNLEGQQFPDDETSEKF AYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAI N-GGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLQELDISRHFTEVIKTHATT--VK SLSQCVLRLPRL---IRLNMLSWLLDADDIALLNVMKERHPQSKYLNILQKWILPFSPII QK--- >P_pygmaeus_ENSPPYP00000012543 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MGPKDSA----------KCLHCGPQPS--HWAAGDGPAQEHCGPRSLGSPVLGLD T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CRAWD--------------------------- --------------HVDGQILGQLRPLAEEEEEEGAGATLS------------------- RGP---AFPGMGSEELRLASF-Y---DWPL-TAEVPPELLAAAGFFH-TGQQDKVRCFFC YGGLQSWKRGDDPWTEHAKWFP-SC---QFLLRSKGRDFVHSVQETHSLLLGS--WD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------PWEEPE---- -----------DAAPAAPSV--PAS-----G----------------------------- -----------------------------DPELPT--HRREVQ----SESAQEP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GA--RDVEEQLRRLQEERRCKVCLDRAVSIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHL-VCAECAPSL---Q LCPICRAPVRSR---VRTFLS--------------------------------------- ----- >E_caballus_ENSECAP00000017749 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SMGPEDKA----------KCWCRGLELS--HQAAGGSPMQGHHRPHCLALSWGGRD H----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------VDGQILGQLHPLAEEEEEGAGAVAAPS------------------ TRP---AFPRMGSEELRLASF-C---HWPL-TAVVRPELLAAAGFFH-TGWQDKVRCFFC HGGLQSWERGDDPWTEHAKWFP-RC---EFLLQTKGRDFVCRVQESCCHQLSS--WD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------QLEEPE---- -----------DAAPSVPST--PVH-----R----------------------------- -----------------------------GPDPPM--PRREAQ-----SGAREP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GA--QNVEEQLQRLREERTCKVCLDRAVSVVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHL-VCAECAPNL---Q LCPICRAPIDSC---VRTFLS--------------------------------------- ----- >D_melanogaster_FBpp0075254 ------------------------------------------------------------ ------------------------------------------------MASVVADLPSYG PIA--------------------------------------------------------- ------------------------------------------------------------ ------------------------FDQVDNNTNATQLFKNNINKTRMNDLNREETRLKTF T-DWP-----------------------------------------LD---WLDKRQLAQ TGMYFTHAGDKV----------KCFFCGVEIG--CWEQEDQPVPEHQRWSPNCPLLRRRT T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NNVPINAEALDRILPPISYDICGANDSTLEMREHAYAEGVI PMSQLIQSIGMNAVNAAGSVTGTAAP-QPRVTVATHASTATQATGDVQPETCRPSAASGN YFP---QYPEYAIETARLRTF-E---AWPR-NLKQKPHQLAEAGFFY-TGVGDRVRCFSC GGGLMDWNDNDEPWEQHALWLS-QC---RFVKLMKGQLYIDTVAAKPVLAEEK------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------EESSSIGGVAVASTQAS E----------EEQQTSLSSEEAVSGD--VAPSVAPTAATRIFNKIVEATAVATP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------STNSSGSTSIPEEKLCKICYGAEYNTAFLP------------------------ ------------------------------------------------------------ ------------------------------------------CGHVVACAKCASSV---T KCPLCRKPFTDV---MRVYFS--------------------------------------- ----- >A_aegypti_AAEL009074-PA ------------------------------------------------------------ ------------------------------------------------------------ ---------MAGVMMAQVLSTPRDFT---------------------------------- ------------------------------------------------------------ ----------------------------DNKVKEDNAYGHTATSVPIS-YHTEVARLESF R-GWM-----------------------------------------VS---FISKTELAR YGFYYVGPNDMV----------KCYFCRVEIG--LWEPNDNVLSEHLRWSPYCPLLRKRQ T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NNVPIDASFLDQ-LPEPSYDTCGIRIRENSVAENAYSSSDR --------------SSSGSLTSPPSSLTSESSMASNGPVVQQLSAPVLPQQ--------- KLP---EYPNYAIEAKRLESY-E---DWPK-FMKQKPKELSDAGFFY-TGKSDRVKCFSC GGGLKDWEAEDEPWEQHAMWYS-NC---EYLKLMKGEAYIAHCLAKKESSSEE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------NGSDVGPSNSPQPSTSGV--VSAATSSLQSSQSSSLSVSAEEDNTAMVGCS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------SDEDEPNRKLDTSRTCKICYVNEYNTAFSP------------------------ ------------------------------------------------------------ ------------------------------------------CGHVVACAKCASSV---T KCPLCRKPFTNV---MRIYLM--------------------------------------- ----- >C_familiaris_ENSCAFP00000018803 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MGPEDRA----------KCWCRGPELG--RGRLSPCGHTEGRDGRC-ARCWGGRD R----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------VDGQILGQLRPLAEEEEAGEPRAGP-------------------- PRP---AFPGMGSEQLRLASF-S---AWPL-TAVVQPELLAAAGFFH-TGQQDKVRCFFC YGGLQSWEQGDDPWTEHAKWFP-RC---EFLLQTKGRDFVCSVQEACCHLLGS--WD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------PSEEPE---- -----------DTAPATPSA--PVH-----M----------------------------- -----------------------------SPELPT--PRREVQ----SEGAREPGKGVEP RPRGCCWVLEPP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GA--RDAEEQLQRLREERVCKVCLDRTVCTVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHL-VCAECAPAL---Q LCPVCRAPIRSC---VRTFLP--------------------------------------- ----- >A_carolinensis_ENSACAP00000005440 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -QP---EYPDLAMERDRLRTY-D---SWPS-DAQVSPEELAGAGFFY-TGDRDYVLCFYC DGALRNWERGDDPWMEHARWFP-RC---EFLLQSRGRDFINSIQDSYFSTLVS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KVVLKDPFPKTGMT--- -----------EKQNPCG-----------NVEIIP--CSREVE----TEQPNQPDST--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LSTEEKLRQLQEERMCKVCMDKDVSIVLVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLVVCSECAPNL---- ------------------------------------------------------------ ----- >E_caballus_ENSECAP00000002314 ----------------------------------------------MATEEKAPAGRDSR FDHALLQELSALLGIDAVQYAKEMEEEEQREREKMQQGFNSRMRSEAKRLKTFATYEAYS SWT-PQEMAAAGFHFTGVRAGVQCFCCGLILFGASLHKRPLDDHKRLRPDCGFLLGEDVG NVA--------------------------------------------------------- -----------------------------KYEVRVRKPPGTL-RGDAARYREEEARLKSF K-DWP-----------------------------------------FYA-QATAPRELSA AGFVFTGSRDAA----------QCFSCGGCLG--NWEDGDDPWKEHAKWFPKCEFLQSKK S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SEEIAQYIQSYEGFVGVTGEHFLNSWVKRVVPMVS AYS---SDSIFANGELRLDSF-K---NWPP-ASPVGAAALAKAGLFY-TGVKDVVQCFSC GVCLENWKEGDDPVEDHTKYSP-NC---QFLQNMKSSAGATPDLQSRDVIPSPTKSTCES NLADSAAVSSPAP--------------------------------------------EMA QGEAQWFQEAKGLSERLRKAYTSARFCNTSLLEVAPCLATDQLLGCDLSLASKRIGSHVQ EPVVLPEVFATLNSVMCVEGEAGSGKTVLLKRIALLWASGGCPLLNRFQLVFYVSLSSAR PDQGLASILCDQLLETEDSVTEMSLRPIIQQLKNQVLFLLDDFREMCSVPRVIEKLIQRN HSSRTCLLIGVRRSRARAIHRHLHTILEIKAFPFYNSIYILRKLFSHNMIRLRNFMIHFG KNKNLQGIQKTPLFVVAVCAHWFRHPLDQ-SFDDVAVFKSYMECLFLKYKTTADLLRATV SSCGELALKGFFSSCFEFRDDDLVEAGVDQDEDLAMCLMSKSTAQRLRPVYQFLSPAFQE FLAGMRLTELLDSDRQEDRELGLHYLREVNSSLMAVIPYSNFFNYVSCHASTKAGPKVVS HLLRLVDKKESLENILESDDYLKHRPEISVHMEYFRVLWQLSPKYYFSQVSEHLLALAIK IAYQSNALAACSPFILRFLQGRTLTFNMLKSQYFFDHPESLLLLRSIQFSIKGRKSSR-L DLSVLETCLDKSQAPTIDQDYASAFEP--AKEWEQNLAEKEENVKSFLDMQLNAPPDIST GYWKLSPKPYKIPLLEVHVTDIDAVDQEMLRVLTAVFSASQHIELHLNDSRGFLESVRPA LEQYKASFTKCSISRFELSAADQELLLTLTSLESLEVSGTTWLRDQLFPNLDKFLCLKEL SVDLDDKQNVFSVIPEDFVNLHHMEKLLIRIAAEHGPSKLVRLIQNSPDLQVFHLQCNFF SDFESLMTVLASCKKLKEIKFSGRFFKAIPFVIVLPNFTSLKMLNLGHQEFPDRETAEKF AYTLGSLDNLEELILPTGDAVHQVAKLIVQQCEHLRGLRVLSFYQTLNDDSLMEIVRALT SGGGFQKLENLNLSINHKITEEGYRNFFQALDSLPRLQELTISRHFTECIKAQAAT--VK SLSQCVSRLPSL---IRLNMLSWLLDAEDVTLLTAMKERHPQSKHLTFHWKWILPFSPII QK--- >C_intestinalis_ENSCINP00000011648 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MAAAGLFY-IGQTDRVKCWYC NGGLQNWLPNDDPWFEHAKWFP-TC---EYVLQQRGPEYVHNVCMQFPNLRRP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------DLPLRNLPSVVSGPSHQTPGG GLLYHQSPQIIDPREETRRRKAKI------DREMIASPLV---NQARQLGFSNNQIRSAF T----------KSFEVSDKTCENMDEL--IDIISNLPNDDHDQARGSNEQTTSYQYSSTA T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------LSRAEEIRAIEESKICKVCRNANACIVLLP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLSVCQGCSVNI---E RCPICRTFTREK---LLTYLV--------------------------------------- ----- >A_gambiae_AGAP007293-PA ------------------------------------------------------------ ------------------------------------------------------------ ----------------MASAVVSCIC---------------------------------- ------------------------------------------------------------ --------------------------------REIAEYRVTHDTPEEC-LNYEVNRLRTF P-LWT-----------------------------------------VP---YIYPEELAR WGFFYTGYRDCV----------RCYFCRIELG--GWDEHDVVIEEHLKWSPHCRLMTKRP T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NNVPIDPDFLDQ-LGEIVPDTTGTG---STSAWSAAA---- --------------TAAVAVAMESNRLNRQNELERQSQRTQNDTIPF------------- YRQ---KYPEYRIGGDRLATF-K---EWPK-SIPQTPTQMADAGFFY-TGKSDVVACYYC GGNLRDWLAEDDPWVEHVRNFS-EC---PYVKLVKTPEFIAECRGEKVT----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------NSALIA------------SSERSGHGN---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------VSKDKEQDEVSDEKCCKICYIRPFDTVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHVVACGKCAAST---T KCPMCNESYTSV---QRIFLS--------------------------------------- ----- >A_gambiae_AGAP007291-PA ------------------------------------------------------------ ------------------------------------------------------------ ----------------MASTVVSCIC---------------------------------- ------------------------------------------------------------ --------------------------------REIAEYRVTHIVPEEC-LNYEINRLRTY DLLWT-----------------------------------------VP---YIYPEELAR WGFFYTGHRDCV----------RCYFCRIELG--GWDEHDVVIEEHLKWSPHCRLMTKRP T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NNVPIDPDFLDQ-LGEIVPDTTGTG---STSAWSAAA---- --------------TAAAA---ESNRLNRQNELE----RTQNDTIPF------------- YRQ---KYPQYRIEGDRLATF-K---EWPK-SMPQTPERMADAGFFY-TGKSDVVACFYC GGNLRDWLAEDDPWVEHVRNFS-EC---PYVKLVKTPEFIAECRGEKVT----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------NSALTA------------GPEHSGHGN---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------VSKDKEQDEVSDEKCCKICFTRPFDTVFMP------------------------ ------------------------------------------------------------ ------------------------------------------CGHVVACGRCAATT---T KCPMCNEPYTSV---QRIYFS--------------------------------------- ----- >A_gambiae_AGAP007292-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------MESHDNTERQERTGLCNELN-YNQEINRLRTY FPLWT-----------------------------------------VP---YIYPEELAR WGFFYTGYRDCV----------RCYFCHIELG--GWDEHDVVIEEHLKWSPDCRLMTKRP T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DNVPVDANFLDQ------LDTAGTG---IPIQLGTAA---- --------------SRYNGPCNRYQPTSSHDNPEWHRQTVLNVSAPV------------- YEP---TIPHYEIGDNRLASF-Q---EWPK-CMKQTPEQMADAGFFY-TGKSDVVICFCC GGQLRDWLPEYNPWVEHAKNFS-GC---PYLKLVKTPGFIAECQAKWYT----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------NDVLIG------------RPEYPGHD----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------VTKRKEQHEVADENCCKICYTRPFDTVFIP------------------------ ------------------------------------------------------------ ------------------------------------------CGHVVACGRCAAST---L NCPVCNKWYTSV---QRILFT--------------------------------------- ----- >O_cuniculus_ENSOCUP00000002871 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------QQDKMRCFFC YGGLQS-ERGDD-WTEHAKWFP-RC---QFLLRSKGRDFVHSIQESGSQLLGP--WD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LWEEPE---- -----------DTAPASPSG--PVH-----Q----------------------------- -----------------------------APELLT--PRTEPW----LESAREPGGTRAR --LRVQRVLGPP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GAGAVAMEEQLRRLQEERTCKVCLDQAVSVVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHL-VCTQCAPNL---H LCPICRAPVRSC---VRTFLS--------------------------------------- ----- >C_intestinalis_ENSCINP00000002312 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MFRC--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QYP---VSPYMRNEESRFETFDH---RWPASNVRASPRQIAIAGFFF-LGDRDRVKCWYC NGGLQNWDPDDEPWTEHAKWFP-TN----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------II N----------RRLTSGGNLYTSVADL--VDDITA--NENEPN----SDDDDETNTSQPS QTTTVKT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------TERKCKICLDKVADIVFVP------------------------ ------------------------------------------------------------ ------------------------------------------CGHLCTCTECAKAL---R KCPICRSKFERG---IKTYMS--------------------------------------- ----- >C_intestinalis_ENSCINP00000008701 MKQRHKYLHNTRKSTAPFNNQINGNAKDKRNYEKKSLKSTLGSKGLHELCLFETFNPEVC KIHPEIKGKSYKSGGKKLRESANTDVQSDGTPAANDDNIAPTPERASEMVFRLLSFKERS DLN-GKNLTNSGFYLEPGGSVIRCYSCGFRVENVTDTDS-GDSAQYHNDDCAHFKQLQSK QPIALKAPPQPPSVEGASFLPSMMDDLDLGLGNQDLQFSIYDPSLTEPYSGFSFENDQKL KYLPQSVNDVSMVPNTSENNEVSDEECPQIYLAQVYSAEHREFLHTLN-LNKESGRLKSF R-NWP-----------------------------------------DN---SLDKTLLAK SGFFYLGNRDRT----------QCFSCMGVLK--NWRPGDVINDIHRDSFPSCSFANAID TPAPALDDYDFSIIRGPPSETFDMALLLNNKPSEARISFEPANQSPTRDIYSSGEAEQMI SDPLSLSLPQSSGELPALNFPQFTSSENAMLNQAEPVSAFRPISSNLLNQSGSSFEITNS SSAASKVKKPSPIFPQPLTPAPVAPPPLALPALDFLAYGETHDSSIVSNTSSKFQTIQIS NPESKQDSNLQPWLNLNTTNAQILIPTPSRTSPQSPLKQVQTAPQDWLLDLDPYKAPLET QSAQPVRDFTFSTTSTSNPEDATTIPIIRSLEGIQNGKTLDFDEYLQEQERTLYRDMFPC LEP---KKMDMKFYEDRIATFDS---RWTR-TGPPTMSDIAQAGFYY-LGDDDAVRCWYC DVTIRDLSRQWIPWEEHAKQFP-SC---HYLLRNRGPDFVENVLSIMTSAESG------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------EPSFPTFP------------------------------------------- ------------------------------------------------------------ -------------------------------------------GEIYESSDEEDSR---E NLP--------------------------------------------------------- ----- >A_gambiae_AGAP011326-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MSSASGS---- ---------------------------------------------------EVQPA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EMP---YMPEFAVLDARIRSF-E---SWRF-GHMQNPTRLAVAGFYY-TGTDDEVRCFQC DAGLRDWLVTDDPWQEHARCFA-EC---TFLRLVFGADTVDEVLRNGIAGFKN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GANTATTPSATVSGP--IDETSSELA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------QRLREENKRMKQERECKICLTQEAEVVFMP------------------------ ------------------------------------------------------------ ------------------------------------------CAHLLSCVQCSTGV---D NCPVCRAVITHR---FRAFIC--------------------------------------- ----- >O_cuniculus_ENSOCUP00000000543 ------------------------------------------------------------ ------------------------------------------------------------ -MESGGKPSLGQFILLGTSSVVTAVLYSVYRQKAQ------------------------- ------------------------------------------------------------ -------------------------------------------------VSRELKGAKKI HLGED-----------------------------------------LKSILSEAPGKCVP ----YAVIEGAVRSVKETLNSQFVENCKGVIQRLTLQEHKMVWNRTTHLWNDCSKIIHQR T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NTVPFDLA--------------------------------- --------------PHEDGVGVAVRVLKPLDAVDLGLETV-------------------- YEK---FHPSVQSFTDVIGHY-I---SGERPKGIQETEEMLKVGATL-TGVGELV----- ---LDNSTVRLQPPKQGMQYYLSSQ---DFDSLLQRQESSVRLWR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VLALVFGFATCATLFFI L----------RRQYLQRQERLRLQQM--------------------QEEFREHEAQL-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LSQARPEDRESLKSACVVCLSNFKSCVFLE------------------------ ------------------------------------------------------------ ------------------------------------------CGHVCSCSECYRALPEPK RCPICRREVTRV---VPLYNS--------------------------------------- ----- >P_pygmaeus_ENSPPYP00000002056 ------------------------------------------------------------ ------------------------------------------------------------ -MESGGRPSLCQFILLGTTSVVTAALYSVYRQKAR------------------------- ------------------------------------------------------------ -------------------------------------------------VSQELKGAKKV HLGED-----------------------------------------LKSILSEAPGKCVP ----YAVIEGAVRSVKETLNSQFVENCKGVIQRLTLQEHKMVWNRTTHLWNDCSKIIHQR T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NTVPFDLV--------------------------------- --------------PHEDGMDVAVRVLKPLDSVDLGLETV-------------------- YEK---FHPSIQSFTDVIGHY-I---SGERPKGIQETEEMLKVGATL-TGVGELV----- ---LDNNSVRLQPPKQGMQYYLSSQ---DFDSLLQRQESSVRLWK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VLALVFGFATCATLFFI L----------RKQYLQRQERLRLKQM--------------------QEEFQEHEAQL-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LSRAKPEDRESLKSACVVCLSSFKSCVFLE------------------------ ------------------------------------------------------------ ------------------------------------------CGHVCSCTECYRALPEPK KCPICRQAITRV---IPLYNS--------------------------------------- ----- >H_sapiens_ENSP00000264198 ------------------------------------------------------------ ------------------------------------------------------------ -MESGGRPSLCQFILLGTTSVVTAALYSVYRQKAR------------------------- ------------------------------------------------------------ -------------------------------------------------VSQELKGAKKV HLGED-----------------------------------------LKSILSEAPGKCVP ----YAVIEGAVRSVKETLNSQFVENCKGVIQRLTLQEHKMVWNRTTHLWNDCSKIIHQR T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NTVPFDLV--------------------------------- --------------PHEDGVDVAVRVLKPLDSVDLGLETV-------------------- YEK---FHPSIQSFTDVIGHY-I---SGERPKGIQETEEMLKVGATL-TGVGELV----- ---LDNNSVRLQPPKQGMQYYLSSQ---DFDSLLQRQESSVRLWK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VLALVFGFATCATLFFI L----------RKQYLQRQERLRLKQM--------------------QEEFQEHEAQL-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LSRAKPEDRESLKSACVVCLSSFKSCVFLE------------------------ ------------------------------------------------------------ ------------------------------------------CGHVCSCTECYRALPEPK KCPICRQAITRV---IPLYNS--------------------------------------- ----- >M_mulatta_ENSMMUP00000009065 ------------------------------------------------------------ ------------------------------------------------------------ -MENGGRPSLCQFILLGTTSVVTAALYSVYRQKAR------------------------- ------------------------------------------------------------ -------------------------------------------------VSQELKGAKKV HLGED-----------------------------------------LKSILSEAPGKCVP ----YAVIEGAVRSVKETLNSQFVENCKGVIQRLTLQEHKMVWNRTTHLWNDCSKIIHQR T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NTVPFDLV--------------------------------- --------------PHEDGVDVAVRVLKPLDSVDLGLETV-------------------- YEK---FHPSIQSFTDVIGHY-I---SGERPKGIQETEEMLKVGATL-TGVGELV----- ---LDNNSVRLQPPKQGMQYYLSSQ---DFDSLLQRQESSVRLWK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VLALVFGFATCATLFFI L----------RKQYLQRQERLRLKQM--------------------QEEFQEHEAQL-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LSRAKPEDRESLKSACVVCLSSFKSCVFLE------------------------ ------------------------------------------------------------ ------------------------------------------CGHVCSCTECYRALPEPK KCPICRQAITRV---IPLYNS--------------------------------------- ----- >E_caballus_ENSECAP00000013139 ------------------------------------------------------------ ------------------------------------------------------------ -MEGGGRPSLGQVILLGTSSVVTAILYSVYRQKAQ------------------------- ------------------------------------------------------------ -------------------------------------------------VAQELKGARRI HLGED-----------------------------------------LKSILSEAPGKCVP ----YAVIEGVVRSVKETLNSQFVDNCKGVIQRLTLQEHKMVWNRTTHLWNDCSKIIHQR T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NSVPFELV--------------------------------- --------------PHEDGVDVAVRVLKPLDALDLGLETV-------------------- YEK---YHPLVQSFTDVIGHY-I---SGERPKGIQETEEMLKVGAAL-TGVGELV----- ---LDNNAVRLQPPKQGMQYYLSSQ---DFDSLLQGQESSARLWK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VLTLVFGFAACAALFFI L----------WKQYLQRQERLRLKQM--------------------EEEFREHEAQL-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LSRAKPEDRESLKSACVVCLSNFKACVFLE------------------------ ------------------------------------------------------------ ------------------------------------------CGHVCSCAECYRALPEPK RCPICRQQITRV---VPLYSS--------------------------------------- ----- >P_troglodytes_ENSPTRP00000000497 ------------------------------------------------------------ ------------------------------------------------------------ -MESGGRPSLCQFILLGTTSVVTAALYSVYRQKAR------------------------- ------------------------------------------------------------ -------------------------------------------------VSQELKGAKKV HLGED-----------------------------------------LKSILSEAPGKCVP ----YAVIEGAVRSVKETLNSQFVENCKGVIQRLTLQEHKMVWNRTTHLWNDCSKIIHQR T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NTVPFDLV--------------------------------- --------------PHEDGVDVAVRVLKPLDSVDLGLETV-------------------- YEK---FHPSIQSFTDVIGHY-I---SGERPKGIQETEEMLKVGATL-TGVGELV----- ---LDNNSVRLQPPKQGMQYYLNSQ---DFDSLLQRQESSVRLWK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VLALVFGFATCATLFFI L----------RKQYLQRQERLRLKQM--------------------QEEFQEHEAQL-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LSRAKPEDRESLKSACVVCLSSFKSCVFLE------------------------ ------------------------------------------------------------ ------------------------------------------CGHVCSCTECYRALPEPK KCPICRQAITRV---IPLYNS--------------------------------------- -----