10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000052344 MDS---IDTKRLND-----SNASDRALSGCAVLFLGCSSLEHNFLSLYKD-ERGKFS-----------------VFKVIKLTLS--DSVGGL--------EGYEILKLHDADP-----YL O_latipes_ENSORLP00000011074 KDP---VDVKKMAD-----TTVDGGAWTGCGVLFLQSLCPDVDLLSLYKN-QNGKFI-----------------VFKVIKLTLTGSDSAGGL--------GGYEILKVHDAEP-----FL T_nigroviridis_ENSTNIP00000003946 -----------MAD-----KTEDGGPWTGCAVLFLRSLSPNVNLLSLYKDHQEGKFT-----------------VFKVLKLTLI--DSARGL--------RGYEILKVHDADP-----LL G_aculeatus_ENSGACP00000020947 -----------MAY-----KTVDGGPWTGCAVLFLRSLCPGVNLLSLFKDREQGKFV-----------------VFKVIKLTLT--DSAGGL--------GGHEILKIHDADP-----FL G_gallus_ENSGALP00000005055 ----------KMAG--------SSTPWIGSAYLFLQSTCKTIILPNLYES-AQKKPC-----------------VFKALKLALA--DSTGSM--------NGVDVLKVHCSHP-----HL T_guttata_ENSTGUP00000006895 ----------KMAG--------SSPPWTGSAYLFLQSTCKTIALPSLYES-SQKKPC-----------------VFKALKLALA--DSTGSV--------NGVDMLKVHCSHP-----HL M_mulatta_ENSMMUP00000007768 -----------MAA-----GQNGHEEWVGSAYLFVESSLDKVVLSDAYAH-PQQKVA-----------------VYRALQAALA--ESGGSP--------EVLQMLKIHRSDP-----QL T_rubripes_ENSTRUP00000046064 IHI---MSHKRMAD-----KSEDGGLWTGSAVLFLQSLCPNVNLLSLYKDHQKGKFM-----------------VFKVIKLTLI--DSARGL--------SGYEILKVHDADP-----FL H_sapiens_ENSP00000341268 -----------MAA-----GQNGHEEWVGSAYLFVESSLDKVVLSDAYAH-PQQKVA-----------------VYRALQAALA--ESGGSP--------DVLQMLKIHRSDP-----QL G_gorilla_ENSGGOP00000011592 -----------MAA-----GQNGHEEWVGSAYLFVESSLDKVVLSDAYAH-PQQKVA-----------------VYRALQAALA--ESGGSP--------DVLQMLKIHRSDP-----QL B_taurus_ENSBTAP00000016776 -----------MAA-----GPNGLEEWVGSAYLFVESSLDKVVLSDAYAH-QQQKVA-----------------MYGALQTALA--ESGGSP--------DVLQMLKIHRSDP-----QL P_troglodytes_ENSPTRP00000046129 -----------MAA-----GQNGHEEWVGSAYLFVESSLDKVVLSDAYAH-PQQKVA-----------------VYRALQAALA--ESGGSP--------DVLQMLKIHRSDP-----QL M_musculus_ENSMUSP00000034359 -----------MAA-----GQNGHEEWVGSAYLFLESAVDKVILSEAYTD-PKKKVA-----------------IYKALQTALS--ESGDSS--------DVLQILKIHCSDP-----QL C_familiaris_ENSCAFP00000030230 -----------MAT-----GPDGLEEWVGSAYLFVESSLDKVVLSDAYAQ-AQQKVP-----------------VYRALRTALA--ESGGSP--------DVLQMLKIHRSEP-----QL R_norvegicus_ENSRNOP00000020405 -----------MAA-----DQNGHEEWVGSAYLFLESSMDKVVLSEAYTD-PKKKVA-----------------IYKALQAALS--ESGDSP--------DVLQILKIHCSDP-----QL M_domestica_ENSMODP00000007741 -----------MAD--------GHQEWSGGAYLFVESTMEKVILSDLYQD-PQKKLA-----------------VFRALKMALA--ECSGSQ--------DGAQILKIHCSGL-----QL E_caballus_ENSECAP00000011430 -----------MAT-----GPNGLEEWVGSAYLFVESSLDKVVLSDAYAH-PQQKVA-----------------VYRALRTALA--ESSGSP--------DVLQMLKIHRSDP-----QL R_norvegicus_ENSRNOP00000023962 MQPDMSLDNIKMASDDLLERKDLDSGGFGKVSLCFHRTHGFVILKKVYTGPNRAEYNEALLEEGKMMHRLRHDRVVKLLGIIIE--EGNYSLVMEYMEQGNLMHVLKTKESVPLSVKGRI 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000052344 GVE--------------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000011074 GVE--------------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000003946 GVE--------------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000020947 GVE--------------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000005055 IVQ--------------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006895 IVQ--------------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000007768 IVQ--------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000046064 GVE--------------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000341268 IVQ--------------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000011592 IVQ--------------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000016776 IVQ--------------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000046129 IVQ--------------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000034359 IVQ--------------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000030230 IVQ--------------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000020405 IVQ--------------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000007741 IVQ--------------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000011430 IVQ--------------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000023962 IVEIIEGMHYLHDEGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEEHNKQREASSVTKKNGGTLYYMAPEHLTDINTKPTEKSDVYSFAIVLWAIFANKEPYENVICTEQFL 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000052344 --------------LKFMAMPPCQRFLESYAC---------GSLTQFLSQHASRLL--ALPDGVEIETQLKAGVHTLDHSLQDIEICL---------------------------DHIRQ O_latipes_ENSORLP00000011074 --------------VKFVNMAACKQFLDSYSS---------GALHQSFSQHAGRLF--AVAQECSVETQLKASTNILDHCLDKLEVCL---------------------------QHIHQ T_nigroviridis_ENSTNIP00000003946 --------------VKFVDVAACQQFLSSYGS---------GALHQSLSQHACRLL--ALPQELRVETQLKASTHVLDLCLDDLQCCL---------------------------KHIHL G_aculeatus_ENSGACP00000020947 --------------VKFNDMLACRQFLESYSS---------GAVRQSLSQHAGRLL--TLPQEFTVETQLKASAHILDLCLDQLELCL---------------------------QHVHL G_gallus_ENSGALP00000005055 --------------LKFCKQENCRRFLQSYRE---------GELQKSLQNHLQLSL--AM-TTVPLEMELKAGNEHLDSMLKDEDRCL---------------------------ECIYR T_guttata_ENSTGUP00000006895 --------------LRFCKEENCRRFLQSYRE---------GALQKSLQSHLQLCL--AT-TMVPLELELKAGSEHLDKMLKDEDRCL---------------------------ECIFR M_mulatta_ENSMMUP00000007768 --------------LRFCGRQPCGRFLRAYRE---------GALRAALQRTLAAAL--AQ-RSVALQLELRAGAERLDALLADEERCL---------------------------SCILA T_rubripes_ENSTRUP00000046064 --------------VKFMDVAACQQFLNSYSS---------GALHQSLSQHACRLL--ALPQELTVETQLKASTHILDLCLDDLERCL---------------------------KHIHL H_sapiens_ENSP00000341268 --------------LRFCGRQPCGRFLRAYRE---------GALRAALQRSLAAAL--AQ-HSVPLQLELRAGAERLDALLADEERCL---------------------------SCILA G_gorilla_ENSGGOP00000011592 --------------LRFCGRQPCGRFLRAYRE---------GALRAALQRSLAAAL--AQ-HSVPLQLELRAGAERLDALLADEERCL---------------------------SCILA B_taurus_ENSBTAP00000016776 --------------LRFSGRQACSRFLRAYRE---------GALRATLQGCLARAL--AL-NSVPLQLELRAGAEQLDALLTNEERCL---------------------------NCICA P_troglodytes_ENSPTRP00000046129 --------------LRFCGRQPCGRFLRAYRE---------GALRAALQRSLAAAL--AQ-HSVPLQLELRAGAERLDALLADEERCL---------------------------SCILA M_musculus_ENSMUSP00000034359 --------------LRFCGRVLCGRFLQAYRE---------GALRTALQRCMAPAL--AQ-EALRLQLELRAGAEQLDSWLTDEERCL---------------------------NYILA C_familiaris_ENSCAFP00000030230 --------------LRFCGRQPCSRFLRAYRE---------GSLRAALQACLAAAL--AQ-RSMPLQLELRAGAERLDTLLTDEERCL---------------------------SCIFA R_norvegicus_ENSRNOP00000020405 --------------LRFCGRLLCGRFLQAYRE---------GALRTALQRCMAAAL--AQ-EAVRLQLELRAGAEQLDSWLTDEERCL---------------------------NYILA M_domestica_ENSMODP00000007741 --------------LKFCGQELCGRFLRSYRE---------GALRDALRNSLVPLLDQAQ-HLGQLHLELHVGSERLDLMLHEEDRCL---------------------------RCIHQ E_caballus_ENSECAP00000011430 --------------LRFCGRQACGRYLRAYRE---------GALRAALQGCLEAAL--TL-QSL-LKLELRAAAERL-LLLTDKERCL-------------------------------- R_norvegicus_ENSRNOP00000023962 VCINSGNRPNVEDILEFCPREIISLMERCWQTNPEDRPTFFGIEKEFKPFYLSQFEEYVEEDVASLKKEYPSQSPVLKRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLPMGPVEESWFS 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000052344 SQPVRLRDDEVTQLEQQLQN---------------SYG---------------------------------------------------------------------------------- O_latipes_ENSORLP00000011074 SQPERLRDEEIDQLEQQLQTQALG--------SAPQQT---------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000003946 SQPERLCDEEIDHLEQMLQSQALRP-------AQQLSS---------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000020947 SQPERLRDEEIEHLEKQLEIQARG--------SEPQPD---------------------------------------------------------------------------------- G_gallus_ENSGALP00000005055 EKPDRLRDEEITELEERLKSLILHQNINNNM-PSKDCM---------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006895 EKPDRLPDEEIMELEERLKSLKLHQSTNNNV-AGKDCS---------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000007768 QQPDRLRDEELAELEDALRNLKCGS-GT----QGGDGE---------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000046064 SQPERLCDEEIDHLEQELRSQALRP-------AEPQSN---------------------------------------------------------------------------------- H_sapiens_ENSP00000341268 QQPDRLRDEELAELEDALRNLKCGS-GA----RGGDGE---------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000011592 QQPDRLRDEELAELEDALRNLKCGS-GA----QGGDGE---------------------------------------------------------------------------------- B_taurus_ENSBTAP00000016776 QKPDRLRDEELTELENALRNLTCGSAGG----QGSDVQ---------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000046129 QQPDRLRDEELAELEDALRNLKCGS-GA----RGGDGE---------------------------------------------------------------------------------- M_musculus_ENSMUSP00000034359 QKPDRLRDEELAELEDELCKLTCDC-TG----QGGAIQ---------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000030230 QKPDRLRDEELSELEDALQNLTCGS-GR----QDGDVE---------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000020405 QKPDRLRDEELAELEDEFCKLTCDS-TG----QGGATQ---------------------------------------------------------------------------------- M_domestica_ENSMODP00000007741 AKPDRLRDEEISDLEDAFRSLTCDPGGGVALASGPEAP---------------------------------------------------------------------------------- E_caballus_ENSECAP00000011430 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000023962 SSPEYPQEENERSVQAKLQEEASYHAFGIFAEKQTKSQPRLNEAYNREEERKRRVSHDPFAQQRVHENVKSAGAKGLPYPSTTSHGNAAHQLSGPASQIKVPLWNNGVYNHHGFGATGTG 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000052344 ----------------PPSQPP---------------Q----------------------------ELPRN------CFLFQKRVFDD--RPLTPADQQRFAAHVGRDWKRVGRALQKNC O_latipes_ENSORLP00000011074 ----------------PLTQEE---------------S----------------------------SVPSN------CFKFQNKIIED--RMLTAVDIQSFSNGVGRQWRHVGRALGKTC T_nigroviridis_ENSTNIP00000003946 ----------------TNQQVE---------------S----------------------------PVPNN------CFRFQNRVFED--RILTAADVQSFSNGVGRQWKNVGRALGRSC G_aculeatus_ENSGACP00000020947 ----------------PPTQEE---------------C----------------------------PVPSH------CFKFQNKPTED--RMLTGGDVQSFSSGVGRQWKHVGRALAKSC G_gallus_ENSGALP00000005055 ----------------SLNSPS---------------L----------------------------PSQGSSLSPQVTFLFQGQQFDN--RTLTPDDHQKFAKLVSKKWKQVGRSLQKNC T_guttata_ENSTGUP00000006895 ----------------SLKSPSQ-------------PY----------------------------PPQGSSLPIQLTFIFQGQQFDN--RAITPDDHQKFAKSVSKKWKQVGRSLQKSC M_mulatta_ENSMMUP00000007768 ----------------VTSAPS-QPPVPSLSDVK--------------------------------PPPAQ------TFLFQGQPVVN--RPLSLQDQQTFARSVGLKWRKVGRSLQRGC T_rubripes_ENSTRUP00000046064 ----------------TNQREE---------------P----------------------------PVPNN------CFKFQNRVFGESGRPCTPATHHTY------------------- H_sapiens_ENSP00000341268 ----------------VASAPL-QPPVPSLSEVKPPPP----------------------------PPPAQ------TFLFQGQPVVN--RPLSLKDQQTFARSVGLKWRKVGRSLQRGC G_gorilla_ENSGGOP00000011592 ----------------VASAPL-QPPVPSLSEVKP-PP----------------------------PPPAQ------TFLFQGQPVVN--RPLSLQDQQMFARSVGLKWRKVGRSLQRGC B_taurus_ENSBTAP00000016776 ----------------GTPAPL-QSLAPSPPEEKP-PP----------------------------PQPGQ------TFLFQGQPIVN--RPLNLQDQQKFARSVGLKWRKVGRSLQRSC P_troglodytes_ENSPTRP00000046129 ----------------VASAPL-QPPVPSLSEVKP----------------------------------------------------N--RPLSLKDQQTFARSVGLKWRKVGRSLQRGC M_musculus_ENSMUSP00000034359 ----------------VASAGS-KFPVSSPTEEK--PL----------------------------PAACQ------TFLFHGQLVVN--RPLTLQDQQTFARSVGLKWRRVGRSLQRNC C_familiaris_ENSCAFP00000030230 ----------------VAPAPS-QSLATSLSEEKPPPP----------------------------PPPGQ------TFLFQGQPIVN--RPLSLQDQQKFARSVGLKWRKVGRSLQRGC R_norvegicus_ENSRNOP00000020405 ----------------VAPAGS-KSLVSSPAEEK--PL----------------------------PAAGQ------TFLFHGQLIVN--RPLNLQDQQTFARSVGLKWRRVGRSLQRSC M_domestica_ENSMODP00000007741 ----------------ALKAPAPKAPAPRVPVHSP-PP----------------------------PMQGQ------TFVFQGQEFAN--RPLNSDDQLKFARLVGRKWRTVGRALQ--C E_caballus_ENSECAP00000011430 --------------------------------------------------------------------------------------MI--RPLSLQDQQTFARSVGLKWRKVGRSLQRSC R_norvegicus_ENSRNOP00000023962 VWYGPSVSQSYNAYKTPVPETNLPGSIPTMPYISLAPPDDSIRCTIYNSSRVQIGNYNYMDLGPSSQPPTNTCKVESTSRHQAVFANT--TSLTDKHLNPIRENMGKQWKNCARKL---- 610 620 630 640 650 660 670 =========+=========+=========+=========+=========+=========+=========+====== D_rerio_ENSDARP00000052344 RALKGPAIDNLAYEYEREGLYEQAYQLLGRFIQSEGRS-AKLSRLISALEETKMTSMAE--IMLGIQPR--D---- O_latipes_ENSORLP00000011074 RALKAPAIDNLAYEYEREGLYEQAYQLLTRFVQAEGRA-AKLSRLVRALEDCKLTSLAE--NLLEIQP-------- T_nigroviridis_ENSTNIP00000003946 RALKGPAIDNLAYEYEREGLYEQAYQLLNRFIQAEGRA-AKLSRLVRALEDCKLTGLAE--NVLDIQPV--FGALA G_aculeatus_ENSGACP00000020947 QALKGPAIDNLAYEYEREGLYEQAYQLLSRFIQAEGRA-AKLSRLVKALEDCKLTSLAERNDLLSLFNG--HTVLS G_gallus_ENSGALP00000005055 RALRDPVIDNLAHEYDREGLYEQAYQMLLRFIQSEGKK-ATIARLIAALEENGLTSLSE--ELLGLHSN--E-DDS T_guttata_ENSTGUP00000006895 RALRDPVIDNLALEYDREGLYEQAYQMLLRFIQSEGKK-ATIARLIAALEENGLVSLAE--ELLGLHST--E-DCS M_mulatta_ENSMMUP00000007768 RALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRR-ATLQRLVEALEENELTSLAE--DLLGLTDP--NGGLA T_rubripes_ENSTRUP00000046064 ---------------------------------------------------------------------------- H_sapiens_ENSP00000341268 RALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRR-ATLQRLVEALEENELTSLAE--DLLGLTDP--NGGLA G_gorilla_ENSGGOP00000011592 RALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRR-ATLQRLVEALEENELTSLAE--DLLGLTDP--NGGLA B_taurus_ENSBTAP00000016776 RALRDPALDSLAYEYERDGLYEQAFQLLRRFVQAEGRR-ATLQRLVEALEENELTSLAE--DLLGLANP--DGSLA P_troglodytes_ENSPTRP00000046129 RALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRR-ATLQRLVEALEENELTSLAE--DLLGLTDP--NGGLA M_musculus_ENSMUSP00000034359 RALRDPALDSLAYEYERDGLYEQAFQLLRRFMQAEGRR-ATLQRLVEALEENELTSLAE--DLLGQAEP--DGGLA C_familiaris_ENSCAFP00000030230 RALKDPALDSLAYEYEREGLYEQAFQLLKRFVQAEGRR-ATLQRLVEALEENELTSLAE--DLLGLTNP--DGSLA R_norvegicus_ENSRNOP00000020405 RALRDPALDSLAYEYERDGLYEQAFQLLRRFIQAEGRR-ATLQRLVEALEENELTSLAE--DLLGQAEP--EGGQA M_domestica_ENSMODP00000007741 PALREQDLENLAYDYDRDGLFEQAFQLLHHFVQAEGRR-ATLQRLIEALDRSSLTSVAE--DLLGLPRVQEDGDHE E_caballus_ENSECAP00000011430 RALRDPVLDSLAYEYEREGLYEQAFQLLRRFVQAEGRR-ATLQRLVEALEENELTSLAE--DLLGLANP--DGGLA R_norvegicus_ENSRNOP00000023962 -GFTESQIDEIDHDYERDGLKEKVYQMLQKWLMREGTKGATVGKLAQALHQCCRTDLLN--QLIQA-------SQS