10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000038477 AAS---EGNSEYLQSVSSESSS----------------------FIMV-----QPKNRLEVPSKMWVTTVV-VIVIVLQVASTTGLFIY------LNMSVAQARTQGMVEE--LRCLGLL T_rubripes_ENSTRUP00000014307 MATPSAQQHQDYFRSVSSESTT----------------------YMMVPAGGANGTRRREAPSKMWVAMVV-LVVVVLQIASTTGLFLY------LNMSISQVRSQGVTEE--LKCLSLL D_rerio_ENSDARP00000022037 MAT---QNNQDYYRSVSSESTT----------------------YMMVP----ANSRGRDSPSKLWIAMVV-IVVVVLQIASTTGLFVY------LNMSLSQVKSQGVTEE--LRCLGLL O_latipes_ENSORLP00000010677 MATPS-----DYFRSVSSDSTT----------------------YMMVPTGGPSGAARRETPSKMWLAMVV-IVVVVLQIASTTGLFVY------LNMSISQVRSQGVTEE--LRCLGLL O_anatinus_ENSOANP00000022049 I-------------------------------------------------PVPHGSRSESPPSRLWARYWVGIVSICCPIVLSKCLVTY------SAMSVLKSQAQGSPEE--LKCLQLI G_gallus_ENSGALP00000011699 M---------------------------------------------------------EQPWTRLLHAFSLELQLLPLCTAPEWAEGTWSQALQGNAFPRLKAQSQGSSEE--LRCLQLI T_nigroviridis_ENSTNIP00000008505 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000048879 L-----------------------------------------------------------------------------CTMPDSADNIWGWKCMQKCFVHLRTQTQGTSEE--LRCLQII T_guttata_ENSTGUP00000005543 F------------------------------------------------------------------------------------------------PSQLKSQAPGSAEE--LRCLQAL A_carolinensis_ENSACAP00000006055 -------------------------------------------------------------------------------------------------FPQLKAEAQGTSEE--LRCLVLL B_taurus_ENSBTAP00000025281 M-------------------------------AL----------KQAPGSRLGQ----I-------CMPIL-IFTVLLQAFGMAVFYMY------FNKELKQMQNKYFKSG--LACFLEE M_musculus_ENSMUSP00000040271 M------------------------------PSS----------GALKDLSFSQHFRMM-------VICIV-LLQVLLQAVSVAVTYMY------FTNEMKQLQDNYSKIG--LACFSKT O_anatinus_ENSOANP00000014821 L------------------------------QNM----------MSSGGPSSSQ----T-------CGLVL-ISTLLLQSVCVAVTYIY------FTNELKQLRDTYAKSA--IACLTNE C_familiaris_ENSCAFP00000022642 -------------------------------SEM----------QAPGGPSLGL----T-------CVLIL-IFRVGLQSLCVAVTYMY------FTRELKQMQDKYSQSG--IACFLKE E_caballus_ENSECAP00000016944 ---------------------------------M----------QASGGPSPGQ----T-------CVLIL-IFTVLLQALCVAVTYLY------FTNELKQMQIKYSKSG--IACFLKE T_guttata_ENSTGUP00000011151 M-------------------------------------------LPAGGPSPAQ----T-------CGAVL-VAAVLLQSVCVALTFLY------FTSELRQLQDSYSKGG--IACLTGE G_gallus_ENSGALP00000014937 M-------------------------------------------LPAGGPSPAH----T-------CGAVL-VAAVLLQSVCVAVTYIY------FTNELKQLWDTYSRSG--TACLTGE R_norvegicus_ENSRNOP00000017758 M------------------------------PST----------GNLKGPSFSQHFTMT-------VICIV-LLQVLLQALTVAVTYMY------FNNEVKQLQDNYSKIG--LACFSKE A_carolinensis_ENSACAP00000016126 M------------------------------MFS----------SSGGGPSAGQ----T-------CSLVL-IFAVLLQSICVAITFLY------FTNELQQLRATYSESN--LACFSRE M_domestica_ENSMODP00000035661 L------------------------------TTP----------SLHGGLSPAQ----A-------CGLVV-SFSLLIQTFLTAATYFY------FTNELKQLQEANSQSG--LHCLTKE P_troglodytes_ENSPTRP00000026894 M------------------------------AMM----------EVQGGPSLGQ----T-------CVLIV-VFTVLLQSLCVAVTYVY------FTNELKQMQDKYSKSG--IACFLKE D_rerio_ENSDARP00000074299 M-------------------------------------------VSMTSSHTMQ-----------YIGLLL-LAAILLQTIAVAVTFIY------FSNVLSTMKETFSKSS--VSCLMRA H_sapiens_ENSP00000372198 M------------------------------AMM----------EVQGGPSLGQ----T-------CVLIV-IFTVLLQSLCVAVTYVY------FTNELKQMQDKYSKSG--IACFLKE M_mulatta_ENSMMUP00000038711 M------------------------------AMM----------EAQGGPSPGQ----T-------CVLIL-IFTVLLQSLCAAVTYVY------FTNELKQMQDKYSKSG--IACFLKE O_cuniculus_ENSOCUP00000012761 M------------------------------SSV----------QALGGPSAGQ----T-------CVLIL-IFTVLLQSLCVAVTYLY------FTNELKQXXXXXXXXX--XXXXXXX T_rubripes_ENSTRUP00000045419 ---------------------------------------------AVVMTGSGP-----------RLGVLL-LLAVLLQTVVVTITVLH------FSAALNSITELFARSS--VSCLTGV T_rubripes_ENSTRUP00000034053 V--------------------------------------------ARLSSRSTP----CVSQSCLSLGLIT-LAAILLQIIAVAVSFVY------FNKLLGQMQESFSRGS--LSCLINA O_cuniculus_ENSOCUP00000004879 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000014844 L--------------------------------L----------RGSAMVLSVQ----A-------LGLVV-LAAILLQTIAVAVSFMY------FSRVLNTMQENFSQSS--VSCLINV O_latipes_ENSORLP00000016621 R-------------------------------------------LSAVMTGSGS-----------RFGVLL-LVLVLLQTVVVTFTVLR------FSAVLHAMKETFARSS--VSCLTGA P_pygmaeus_ENSPPYP00000015988 M------------------------------AMM----------EVQGGPSLGQ----T-------CVLIV-IFTVLLQSLCVAVTYVY------FTNELKQMQDKYSKSG--IACFLKE G_gorilla_ENSGGOP00000014189 M------------------------------AMM----------EVQGGPSLGQ----T-------CVLIV-VFTVLLQSLCVAVTYVY------FTNELKQMQDKYSKSG--IACFLKE G_aculeatus_ENSGACP00000014440 ---------------------------------------------EMAVSLSLQ----S-------LGLVL-LAAILLQTIAVAVSFVY------FNRVLSTMQETFSRSS--VSCLINA E_caballus_ENSECAP00000014214 ----XRSYSKFWRNTEEMGGG----GAKHE--------------DPLLPRRPAKPSAPQPAAASRSMFVAL-LGLGLGQVVCSVALFLY------FRAQMD--PNRISEDD--THCINRI T_nigroviridis_ENSTNIP00000011552 ------------------------------------------------MTGSAP-----------QLGLLL-LLAVLLQTLVVTITVLH------FTAALGSVTELFARSS--VSCLTGD T_nigroviridis_ENSTNIP00000009448 ---------------------------------------------AMASSASLQ----C-------LALVT-LAAILLQVVGVAVSFIY------FSKVLDTMQESFSRGS--VSCLINT M_musculus_ENSMUSP00000022592 MRRASRDYGKYLRSSEEMGSGP---GVPHE--------------GPLH-PAPSAPAPAPPPAASRSMFLAL-LGLGLGQVVCSIALFLY------FRAQMD--PNRISEDS--THCFYRI O_anatinus_ENSOANP00000007357 ---------------------------------------------------------------------------------------------------ME--PSRISEDD--THCLETL B_taurus_ENSBTAP00000011745 MRRASRDYTKYLRGSEEMGGA----GAPHE--------------GPL--HAPPPPATPAAAAASRSTFVAL-LGLGLGQVVCSVALFLY------FRAQMD--PNRISEDD--THCINRI C_familiaris_ENSCAFP00000006955 MRRASRDYSKYLRGPEEAGGGP---GAPHD--------------GP----PPAPPAPPAPPPASRSVAVAF-LGLGLGQVVCSVALFLY------FRAQMD--PNRISEDD--THCINRI P_troglodytes_ENSPTRP00000009919 --RASRDYTKYLRGSEEMGGGP---GAPHE--------------GPL--HAPPPPAPHQAPAASRSMFVAL-LGLGLGQVVCSVALFLY------FRAQMD--PNRISEDG--THCIYRI M_domestica_ENSMODP00000036348 MRRTSRDYTKYLRGSEEMGSGS--SSAPHE--------------GPL--HPAPSPAPHQPPPTSRSILMAF-MVLGLGQVVCSVALFLY------FKTQMD--LNRISDDE--TCCFLKL M_mulatta_ENSMMUP00000023500 MRRASRDYTKYLRGSEEMGGGP---GAPHE--------------GPL--HTPPPPAPHQPPAASRSMFVAL-LGLGLGQVVCSVALFLY------FRAQMD--PNRISEDS--THCIYRI H_sapiens_ENSP00000239849 MRRASRDYTKYLRGSEEMGGGP---GAPHE--------------GPL--HAPPPPAPHQPPAASRSMFVAL-LGLGLGQVVCSVALFFY------FRAQMD--PNRISEDG--THCIYRI P_pygmaeus_ENSPPYP00000006060 MRRASRDYTKYLRGSEEMGGGP---GAPHE--------------GPL--HAQPPPAPHQPPAASRSMFVAL-LGLGLGQVVCSVALFLY------FRAQMD--PNRISEDG--THCIYRI R_norvegicus_ENSRNOP00000013210 MRRASRDYGKYLRGSEEMGSCP---GVPHE--------------GPLH-PAPSAPAPAPPPAASRFMFLAL-LGLGLGQVVCSIALFLY------FRAQMD--PNRISEDS--TRCFYRI X_tropicalis_ENSXETP00000054163 MSPGGYL-------------------------------------RGAAEIQLAPESAHRSRTVPRSVFVAL-FTLAVAQVGCTLGLFLY------FKAQGD--SSRMPE----LHCWKAI G_gorilla_ENSGGOP00000010907 ---------------------------------------------------------------------------------------------------MD--PNRISEDG--THCIYRI G_gallus_ENSGALP00000027360 ---------------------------------------------------------------------------------------------------MD--PSRISKED--AHCVRML T_guttata_ENSTGUP00000012735 -----------------------------------------------------PPAHQHPPPASQSLLAAL-VLLGLGQVVCSVALFLY------FRAQMD--PTRISKEH--AHCVRTL A_carolinensis_ENSACAP00000001868 MRRASRDYSKYLRGAEELGGGGPHESAPPT--------------PPG--PGGAAPQPHAAPAASRTLLAAL-AVLGLGQVVCSLALFLY------FRAQMD--PNRISEED--THCLRTF O_cuniculus_ENSOCUP00000009507 ---------------------------------------------------------------------------------------------------MD--PNRISADS--THCIYRI C_familiaris_ENSCAFP00000004996 MAENLGLGFRETASVEMLP-------------------------EEGSCTPKARARLATR---SHACWALT-CCLVSFPILAGLTTYLL------------------------------- E_caballus_ENSECAP00000012153 MAEHLGLGFGETASVEMLP-------------------------EDGSCGPHARARLAARRSSSSACWALT-CCLVALPILAGLTTYLL------------------------------- O_cuniculus_ENSOCUP00000010059 MAENLGLDFGETASVEMLP-------------------------QDGTCRPKARN--------SSASWALT-CCLVFLSILIGLSAYLL------------------------------- T_guttata_ENSTGUP00000003285 MESAAEM-------------------------------------GAEAAGSGHGAGLRLRQDLRRIRCALL-LCLLAVLLLMLPTAYLL------------------------------- R_norvegicus_ENSRNOP00000011845 MAEELGLGFGEAVPVEMLP-------------------------EGCRHRREARTGLAAR---SKACLALT-CCLLSFPILAGLSTLLM------------------------------- G_gallus_ENSGALP00000039261 MDHGAEIT------------------------------------LEEASATGQASRMHIKEDLRRMRCAVL-LCLLAVLLLALPIAYLL------------------------------- P_troglodytes_ENSPTRP00000036375 MAEDLGLSFGETASVEMLP-------------------------EHGSCRPKARS--------SSARWALT-CCLVLLPFLAGLTTYLL------------------------------- M_mulatta_ENSMMUP00000016931 MAEDLGLSFGETASVEMLP-------------------------EHGSCRPKARS--------SSACWALT-CCLVLLPFLAGLTTYLL------------------------------- M_musculus_ENSMUSP00000050144 MAEELGLGFGEGVPVEVLP-------------------------EGCRHRPEARAGLAAR---SKACLALT-CCLLSFPILAGLSTLLM------------------------------- M_domestica_ENSMODP00000024427 MPKGKGSALEPEPRVEMLQ-------------------------EEGGDHGTNHSTRRDQ---RKMNPAVT-FCMLLVFILTVLIIYLL------------------------------- H_sapiens_ENSP00000363157 MAEDLGLSFGETASVEMLP-------------------------EHGSCRPKARS--------SSARWALT-CCLVLLPFLAGLTTYLL------------------------------- B_taurus_ENSBTAP00000036310 MAESLTLGFRETASVEMLP-------------------------EDGGCRPKARAGLASRR--SSAHWPLT-CCLLSIPILAALTTYLL------------------------------- G_gorilla_ENSGGOP00000010545 MAEDLGLSFGEXASVEMLP-------------------------EHGSCXPKARS--------SSARWALT-CCLVLLPFLAGLTTYLL------------------------------- X_tropicalis_ENSXETP00000052879 MI------------------------------------------NSYNQSPPAHMSQQASSSTMKTTMWIF-TLFILAQIIGTSIFGVY------FYKKLDKMEEEMSFSA--DYLFLRR P_pygmaeus_ENSPPYP00000021893 MAEDLGLSFGETASVEMLP-------------------------EHGSCRPKARS--------SSARWALT-CCLVLLPFLAGLTTYLL------------------------------- D_rerio_ENSDARP00000075321 MTSNLP--------------------------------------IGPNYSQLDENASENSHAKEQYIFYLI-LTFILSTETFITAFFLY-----DYSRDIHRTSEMVVDEGFPIHCLSTN O_anatinus_ENSOANP00000016821 N-----------------------------------------------------------------------RLIHHVHQIPTRVLFLS------------------------------- O_anatinus_ENSOANP00000001418 MQQNLNYLYPQIYWVDSNAGSPCVPPAPCPPPTPPPVPERPGRRRPPPPPPPLPKTRRDHGTCLGLLMVFF-MVLVALVGLGLGMFQIF-----HLQKDLADLREFWSSLF--------- M_domestica_ENSMODP00000017609 M-------------------------------------------NEPYSPPAPPAGNSGPAATMKIVVCLL-TLFVIAQIIGTAFFGVY------FHKKLDEVQKERCQQA--NSVLTIL M_domestica_ENSMODP00000032553 MGDPVIHPSVFVVD------------------------------GQTDMPFTRLGGSKQRACQRTQLGLGL-LLLLALAGVAIEGYFLW-----SFHWDLMALSLRLPPQP--------- T_rubripes_ENSTRUP00000014782 M---------------------------------------------EAGHNRFQSVQTSDSTYRSILFGTL-VVMGLLQVASSIAILLH------LTGYLQE------------------ T_guttata_ENSTGUP00000002174 M-------------------------------------------NEPYGPEAPRPISSTSPGTMKMFMGFL-TVFTIVQTIGTVLFCLY------LHMKMDKMEEVLSLNE--DYIFLKK A_carolinensis_ENSACAP00000003654 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000018492 M-------------------------------------------NEVYSQPSPRSVNTGSPATMKFLLGFL-TVFVTAQIIATALFGIY------LHRRLDKVKDEMSLHE--DYVFMKT T_nigroviridis_ENSTNIP00000014509 MATSHGEYRGYLRNTI----------------------------DTEAGQSRFQA--SPESTYRSILFGTL-VIMGLLQVASSIAILLH------LTGYLQEIDLSTAPHP--------- X_tropicalis_ENSXETP00000056100 L-------------------------------------------------------------------------------NSFPSNFMY------------------------------- 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000038477 NAMEKEQDVP-----DDLVQLFGEPCIKLAEGLKAYIS--KVTEN-IISK--HTFEE----RVSFP-----PRTKLLT-TGS---PRPSAHLTLRDSGLQEMPQSS--TTSLTPQMDLHQ T_rubripes_ENSTRUP00000014307 NALHKDPDIP-----DQLAQLLGEPCMKLAEGIKAYIS--KVTEN-IISK--QTFIE----ARNMPRIFNTSG-SKLS-PVT---QRPSAHLTLRDTNSQG------FPSYPSNTPGLHQ D_rerio_ENSDARP00000022037 NVLGKDQDIP-----EDLAQLFGEPCMKLAEGIKAYIS--KVTDS-IISK--QTLHA----ARTQTHSYNTTGSKFMT-TVM---QRPSAHLTLSSASDNSRPQSD----MHQPQFDLHQ O_latipes_ENSORLP00000010677 NAL--DQDIP-----DQVAQLLGEPCIKLAEGIKAYIS--KVTEN-IISK--QTFIE----ARKMPISFNNS--NFMS-HVV---QRPSAHLTLRDTTSQVHQLSD-MLKIRTITPGLHQ O_anatinus_ENSOANP00000022049 NSLQEVE--------DLEDLFSNQSCLKLVGNLKSYVT--TVTED-ILRR--SIQKG----ARS--GFANASEGQLMP-GSLAPGAQPSAHLTLQPHGSPSDGESA----PPTPRRELPQ G_gallus_ENSGALP00000011699 NQQQEGS--------NLEELISN-SCLKLANTIKAYVA--AVTEN-VISR--SVVNE----AQK--SYFNISEGQVAT-KTL---GKPSAHLIFRPQNPAQDGSSR----RFG---NLSQ T_nigroviridis_ENSTNIP00000008505 --------------------------MKLAEGIKAYIS--KVTEN-IISK--QTFIE----ARTMPRLFNTSGS-RLG-QVT---QRPSAHLTLRDTNSLARPLSPGFPSLPSPTPGLHQ X_tropicalis_ENSXETP00000048879 NKMEDLSDPMDY---DLDGLIPNESCKKLTSSIKSYINQEKVPEY-FYNYIFSISAE----ARR--SIINISEAQPHR-GEY---MKSSAHLILNQGSPLGKGPSE-----DLVSGNSFQ T_guttata_ENSTGUP00000005543 NQQLEGS--------SLEKLSSSQGCLKLASTIKAYVA--TVTEN-IIRR--SVVKE----AWR--SYFNTSEGQLPP-KIA---GKPSAHLTLRPQSLAQDGRSQ----RSG---NLSQ A_carolinensis_ENSACAP00000006055 NRLQDLS--------NWEELVGNQSCLKMASSIKNYVT--GVTED-VIQK--SAQAA----MQV--SFFKLSSDQPLT-SQP-LGGRPSAHLTLRRLSPVQPEALA----KFG---QLPQ B_taurus_ENSBTAP00000025281 DDRSWD---------SRDDESIINPCWELKSQLYLFVK--KMTLR-TFEE--MIPTN----PEKQYN-PYLE----RE-KGP---KRVAAHITGSNRKK-STLPVPGS--------KNEK M_musculus_ENSMUSP00000040271 DEDFWD---------STDGEILNRPCLQVKRQLYQLIE--EVTLR-TFQD--TISTV----PEKQLSTPPLP----RG-GRP---QKVAAHITGITRRS-NSALIPIS--------KDGK O_anatinus_ENSOANP00000014821 DFGAFIWNWDP----NDNEERNSSPCWQIKWQLLQLIR--KCLLN-SRAS--TMMLLFIRHPDQRQNILPPAK-ERGL-NIL---QRIAAHVTGNYRKR-NHLPRESS--------WLGG C_familiaris_ENSCAFP00000022642 DDIPWD---------PSDEESMNNPCWQVKWQLRQFVR--KMILK-TYEE--TIPTA----PEKQLNIPYVV----SD-RGS---QRVAAHITGTSRR--SMFPIPSS--------KNDK E_caballus_ENSECAP00000016944 DDSDWD---------PNDEESMNSPCWQVKWQLRQFVR--KMILR-TYEE--SIPTT----SEKRQNIPPLV----RE-RGL---QRVAAHITGTSRRR-STVSIPRS--------KNEK T_guttata_ENSTGUP00000011151 EIGNSIQNLEL----VESEDREADPCWQVKWHLGKLIK--KMMSK-SYEE--NISAI----NVEKTLTLPHTEAQQPR-GPG---RRIAAHLTGSSSRRSSLSPRINP--------FPRR G_gallus_ENSGALP00000014937 ELGDLIQNLDV----VESKDRVADPCWQVKWHLGKLIK--KMMSR-ILQE--NMSAI----NGDRTQALPRRD-EPPQ-GPT---LRIAAHLTGSSKRS-SASPH-NY--------LSYR R_norvegicus_ENSRNOP00000017758 DGDFWD---------STDEGILNRPCLQVKRQLYQLIE--EVTLR-TFEK--TISTV----PEKQLSTPPLP----RG-RRP---QRVAAHITGITRRS-NLALIPIS--------KDGK A_carolinensis_ENSACAP00000016126 DVLLQDV--------DADNIDESDPCWQVKWQLSRLIK--KVLDL-GNTS--SSGTS----QVSTAN-----EREVSK-NAV---PRVAAHLTANQNRR-HPENILSP--------ALQN M_domestica_ENSMODP00000035661 YLGAMMGNSDP----SSTTEPIDSVCLQVKWHLQQLIK--KELLT-IYED--SSTR-----QGKRQNNVSGAREGFNQ-SAI---QSVAAHLTINRQIS-PPFSR-TL--------MPGS P_troglodytes_ENSPTRP00000026894 DDSYWD---------PNDEDSMNSPCWQVKWQLRQLVR--KMILR-TSEE--TISTV----QEKQQNISPLV----RE-RGP---QRVAAHITGTRGRS-NTLSSPNS--------KNEK D_rerio_ENSDARP00000074299 NLRTIKGQE------LNGAEGKDDPCWQVTQQLHFLIE--KSMSS-RYQK--EITSAV---KDEVSRVLPSLVIQDQEDSSR---PKIAAHVTGSYT---PESEKDGAGL------PNRK H_sapiens_ENSP00000372198 DDSYWD---------PNDEESMNSPCWQVKWQLRQLVR--KMILR-TSEE--TISTV----QEKQQNISPLV----RE-RGP---QRVAAHITGTRGRS-NTLSSPNS--------KNEK M_mulatta_ENSMMUP00000038711 DDSSWD---------PNDEESMKSPCWQVKWQLRQLVR--KMILR-TSEE--TISTV----QEKQQNTSPLV----RE-RGP---QRVAAHITGTRGRS-NTLSSPNS--------KNEK O_cuniculus_ENSOCUP00000012761 XXXXXX---------XXXXXXXXXXXXXXXXXXXXXXX--XMLLR-TYEE--TIPTV----EEKPQTIPSLVREKERE-RGP---QRVAAHLTGNSWRSFISVPAPGS--------QSGK T_rubripes_ENSTRUP00000045419 EL-------------QGVTAERGGPCWQVTQQLHLLIE--KSLSE-RFQR--QISSAV---RDEVSRVLPSLVMVDRG-SPR---PKVAAHVTGSFV---PQLDR-EGRAPAS---AGRR T_rubripes_ENSTRUP00000034053 NPHTDQ---------DLAEDKKSDPCWQVTQQLHHHIE--KAMAD-RFQK--EISDVM---RDKLTGLLPVLSPGPQG-APL---PKVAAHVTGVAPLTELPVADGEDP-------LARG O_cuniculus_ENSOCUP00000004879 -----------------------------------------------------------------------------------------------------------S--------QSGK O_latipes_ENSORLP00000014844 KLPSEVVD-------SAAEDKNSDPCWQVTQQLHYLIE--KKIAD-SFQK--EISSAV---SNKLTGVLPVLHPGIPG-VPL---PKVGAHVTGVASSLKPPIEEMSGAAAGSR--STTG O_latipes_ENSORLP00000016621 NL-------------QSFMAVQGDPCWPVTQQLHLLIE--KSLSQ-RYQK--QLSSAV---RDEVSRVLPSLVMEDRA-SLQ---PKVAAHVTGSVV---PKLQQGGGALCHSFSLPQRR P_pygmaeus_ENSPPYP00000015988 DDSSWD---------PNDEDSMNSPCWQVKWQLRQLVR--KMILR-TSEE--TISTV----QEKQQNVSPLV----RE-RGP---QRVAAHITGTRGRS-NTLSSP-------------- G_gorilla_ENSGGOP00000014189 DDSYWD---------PNDEESMNSPCWQVKWQLRQLVR--KMILR-TSEE--TISTV----QXXXXXXXXXX----XX-XXX---XXXXXXXXXXXXXX-XXXXXXXS--------KNEK G_aculeatus_ENSGACP00000014440 NLRSDVE--------NSSEEKKGDPCWQVTQQLHHHLE--KTMAD-RFQK--EISTAM---RNEMTGAEPSRTSGVRG-VPL---PKVAAHVTGVVSSTEPPTADGNDPL------ISRG E_caballus_ENSECAP00000014214 FKLHENADLQDTTLESQDTKLIPDSCKRIKQAFQAAVQ--KELQH-IVRSQHIRAEK----ATVEGSWLDLARRGKPD-------TQPFAHLTINATDIPSGSH---------------- T_nigroviridis_ENSTNIP00000011552 EL-------------QGATAERGDPCWQVTQQLHLLIE--KSLSE-RFQR--QISSAV---RDEVSRVLPSLVMVDGGSSPR---PKVAAHVTGSFA---PQLDRDEGGAPAS---AERR T_nigroviridis_ENSTNIP00000009448 NLGADQ---------DLAEDQKSDPCWQVTQQLHHHIE--KAMAD-RFQK--EISSVM---RDKLTGLPPVRSPGTQG-VPL---PKVAAHVTGIAPFTEPPAADAGLR-------SSRG M_musculus_ENSMUSP00000022592 LRLHENADLQDSTLESEDT--LPDSCRRMKQAFQGAVQ--KELQH-IVGPQRFSGAP----AMMEGSWLDVAQRGKPE-------AQPFAHLTINAASIPSGSH---------------- O_anatinus_ENSOANP00000007357 LKFRTNSALQETPLGGQEAKLMSDSCRKMKQAFQGAVE--KELQH-IVGKEHTRAEK----AIMEGSWLDLARISKPE-------QQPFAHLTINGTNIPSGSH---------------- B_taurus_ENSBTAP00000011745 FKLHENTDLQDTTLESQDSKLIPDSCKRIKQAFQAAVQ--KEMQH-IVKSQHIRAEK----AMVEGSWLDLARRNKPE-------IQPFAHLTINATDIPSGSH---------------- C_familiaris_ENSCAFP00000006955 FKLHENADLQDTTLENQDTKLIPDSCKSIKQAFRAAVQ--KELQH-IVRSQHIRAEK----AMMEGSWLEMARRGKTH-------TQPFAHLTINATDIPSGSH---------------- P_troglodytes_ENSPTRP00000009919 LRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQ--KELQH-IVGSQHIRAEK----AMVDGSWLDLAKRSKLE-------AQPFAHLTINATDIPSGSH---------------- M_domestica_ENSMODP00000036348 LKRHKNSDLQDTSLEDQDATLMSDSCRRLKLGFQEALQ--KEKLK-VWLPQQDSVSK----SMMD-PWLDVSRKSRSE-------TQPFAHLTINGTNIPSGSR---------------- M_mulatta_ENSMMUP00000023500 LRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQ--KELQH-IVGSQHIRAEK----AMVDGSWLDLAKRSKLE-------AQPFAHLTINATDIPTGSH---------------- H_sapiens_ENSP00000239849 LRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQ--KELQH-IVGSQHIRAEK----AMVDGSWLDLAKRSKLE-------AQPFAHLTINATDIPSGSH---------------- P_pygmaeus_ENSPPYP00000006060 LRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQ--KELQH-IVGSQHIRAEK----AMVDGSWLDLAKRSKLE-------AQPFAHLTINATDIPSGSH---------------- R_norvegicus_ENSRNOP00000013210 LRLRENTGLQDSTLESEDTEALPDSCRRMKQAFQGAVQ--RELQH-IVGPQRFSGVP----AMMEGSWLDVARRGKPE-------AQPFAHLTINAANIPSGSH---------------- X_tropicalis_ENSXETP00000054163 AKKREHEHIK-----DSSTQDEFMLCEGIKQAFSTAVE--KELHG-FLSSKQFQVGN----ARTETRY-----GSRNN-------SWPVAHLTIGNITPSNSEQS--------------- G_gorilla_ENSGGOP00000010907 LRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQ--KELQH-IVGSQHIRAEK----AMVDGSWLDLAKRSKLE-------AQPFAHLTINATNIPSGSH---------------- G_gallus_ENSGALP00000027360 FRSQESIDLQDTPFENQEVKLMPESCRRMKQALQRAVQ--KEVQR-ILGKESPRPEK----AAMEAIGMELYRRNKPE-------KQPFAHLIIDDKNIPTGTR---------------- T_guttata_ENSTGUP00000012735 FGHQESTDLHDASFESQEVKLMPESCRSVKQALQRAVQ--REVQR-AMGRTPPRPEK----AAMEALGLELYKRNKPE-------KQPFAHLIIDDKNIPSGTR---------------- A_carolinensis_ENSACAP00000001868 LRLQGNIDLQETTLVNQE-RLMSESCRRMKQAFQGAMQ--KEVQRIIIGKDQSRSEK----SIMGASWLDLPKINKPD-------NPPFAHLIIDGNKIPAGTG---------------- O_cuniculus_ENSOCUP00000009507 LRLQENEDLQDAALESQDTKLMPDSCRRIKQAFQGAVQ--KELQH-IVGSQHLRAEK----AVMEGSWFDLAKKGKPE-------TQPFAHLTINATNIPSGSR---------------- C_familiaris_ENSCAFP00000004996 ---------------LGQLRAQGDTCV----------------------------------FQAPKGQEFGHSHQRAYASPRAGGDKPRAHLTVVRQSPTQPLES--------------- E_caballus_ENSECAP00000012153 ---------------VGQLRAQGEASM----------------------------------LASLKEEKLSPSPTQGEQSPR--GHKPRAHLTVVRQTPTQPMKN--------------- O_cuniculus_ENSOCUP00000010059 ---------------VGQLQTQGEACVQ---------------------------------FQTLKGREFGPSQQRAYMPLRADGNKPRAHLTAVKQTPTQPLRN--------------- T_guttata_ENSTGUP00000003285 ---------------VGNLRAPSSCGSQV--------------------------------TEERGSHFLKQRAVAAVTDTLSSAEKPRAHLTVKKQDLASAVGS--------------- R_norvegicus_ENSRNOP00000011845 ---------------TGQLRIPGKDCM----------------------------------FPTVTEERSAPSAQPVYTPSR---DKPKAHLTIMRQTPVPHLKN--------------- G_gallus_ENSGALP00000039261 ---------------AGNLRAPTS-CPQV--------------------------------VDERSSHFLKQRAVAAVTDTLPSAEKPRAHLTVKKQEPSSTTGS--------------- P_troglodytes_ENSPTRP00000036375 ---------------VSQLRAQGEACVQ---------------------------------FQTLKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHLKN--------------- M_mulatta_ENSMMUP00000016931 ---------------VSQLRAQGEACVQ---------------------------------LQDLKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHLKN--------------- M_musculus_ENSMUSP00000050144 ---------------AGQLRVPGKDCM----------------------------------LRAITEERSEPSPQQVYSPPR---GKPRAHLTIKKQTPAPHLKN--------------- M_domestica_ENSMODP00000024427 ---------------VDNVRSQQKMCASGQVRQS---------------------------MPLTGGLDGESGSGMVYTPHRSNSDKPRAHLTAIRQNPMTPMKD--------------- H_sapiens_ENSP00000363157 ---------------VSQLRAQGEACVQ---------------------------------FQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKN--------------- B_taurus_ENSBTAP00000036310 ---------------VGQLRAQGEACE----------------------------------LRTPKEQEIGPSHQRAYAPPGADREKPRAHLTVVRQTPMQPLKN--------------- G_gorilla_ENSGGOP00000010545 ---------------VSQLRAQGEACVQ---------------------------------FQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVRQTPTQHLKN--------------- X_tropicalis_ENSXETP00000052879 IQKCMK---------GDNVDPTLLNCKEVLAKFRQLIS----------EVHSIFSFKLAEWNMHLSHTFKRFKSLNMFLIAESEQPVIAAHLVGEKSNN--------------------- P_pygmaeus_ENSPPYP00000021893 ---------------VSQLQAQGEACVQ---------------------------------FQDLKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQH-KN--------------- D_rerio_ENSDARP00000075321 LS-------------QPADQAGITSCDLFNQELKQTAH-----------------------QQRLLLDIQNYLLETFGDHNITEIFKPAVHVGAKQELKQYQSLQI-----------NDE O_anatinus_ENSOANP00000016821 -----------------------------------------------------------------------------------------LTFVVVQQNPAPNVKD--------------- O_anatinus_ENSOANP00000001418 ----------------------------LQSSLSISLN----------------------------PGLQHPASEKET-------LRKVAHLTGKSNSKAA------------------- M_domestica_ENSMODP00000017609 KE-------------CNHKDSSKLNCQEIEAYFQKLLQ-----------VNSYIRPK----ESPTKEMFEKQKGDQKQ-------LPIAAHLTSNTNSK--------------------- M_domestica_ENSMODP00000032553 ----------------------------LVSDLFLFLE-----------------------RRSYQ-------------------DKPAAHLTGVNSSLVM------------------- T_rubripes_ENSTRUP00000014782 -------------------------------------------------------------EVQIEPVLNALKDNRKRRCKTSRESLPSAHLPITTHQMYSKKGEP-------------- T_guttata_ENSTGUP00000002174 VQKCQT---------VEGQKSTLLDCEKIIKGFEDIQC--KDRPP-KEQPKFEMQRG----PEHHEH--SRLMHKNETSVAAEKREPIAVHLAGQQSNK--------------------- A_carolinensis_ENSACAP00000003654 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000018492 VQKCH----------NGGASSTLLNCEEIRHRFQKLLE-----------RKLIWLRR----KRRKEKHFSNHRNYEQK-------HPIAAHLIGVKNNE--------------------- T_nigroviridis_ENSTNIP00000014509 -----------------------------------PIE-----------------------EAQIEPVLNALRDTRRRRCKTLRESLPSAHLPIRAQQMYSKKGEP-------------- X_tropicalis_ENSXETP00000056100 -------------------------------------------------------------------------------------NFPAYSLLVFLISAKAGKKQ------------YSY 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000038477 SCRHPVRSWGN-QSF-GSHLHN-MTVS-NGRLR-VPRAGRYYLYAQVYFRYLTLSVDDY---------HSGSVSHQVVQCVYKKTA-Y-----ARPIQLLKGVGTKC-WS-PDSENALHS T_rubripes_ENSTRUP00000014307 SCRHVVRSWAN-QSF-GAHLHN-MTLT-NGKLR-VPQDGRYYLYSQVYFRYPSPAASDG---------DQRSVSHQLVQCVYKKTS-Y-----PSPIQLLKGVGTKC-WA-PDAEYALHS D_rerio_ENSDARP00000022037 SCRHPVHTWAN-KSF-GAHLYN-MTLT-NGRLR-VPQDGRYYLYSQVYFRYPSP--SDS---------DQSSVSHQLVQCIYKKTS-Y-----LNPIQLLKGVGTKC-WA-PDAEYALHS O_latipes_ENSORLP00000010677 SCRHMVRSWAN-QSF-GAHLHN-MTLS-NGKLR-VPQDGRYYLYSQVYFRYPSPVASDG---------DQRSVSHQLVQCVYKKTS-Y-----PSPIQLLKGVGTKC-WA-PDAEYSLHS O_anatinus_ENSOANP00000022049 SCRHPIQNWED-LGL-LSHLRN-VTHR-AGALR-INQGGKYYVYSQIYFRYLAEGP------------GARPSARQLVQCVSRRTS-Y-----RQPILLLKGVGTKC-WA-PEAEYGLHA G_gallus_ENSGALP00000011699 SCRHAITRWED-STI-HSHLQN-ITYR-DGRLR-VNQAGKYYVYSQIYFRYSRDGA------------GARVSVPQLVQCINWKTS-Y-----SQPILLLKGVGTKC-WA-PEAEYGLHA T_nigroviridis_ENSTNIP00000008505 SCRHVVRSWAN-QSFVGAHLHN-MTLT-NGQAAGARRTGGYYLVIPQTFRYPVPRPGRR---------GPTQRSAQPTQLVPVRST-KRDVLPPSPIQLLKGVGTKC-W--PDAEYALHS X_tropicalis_ENSXETP00000048879 SCRYPIRQWQL-RNA-LSHMQN-MTYH-DGHIK-ILQDGLYYIYSQIYFRYTKQKD------------SRPSLGHQLVQCINKKTS-Y-----VNPILLLKGVGTKC-WA-PNAEYGLHS T_guttata_ENSTGUP00000005543 SCRHAITHWGH-SSL-LSHVQN-MTYR-AGRLR-VEQPGKYYVYSQIYFRYRGAG---------------RDSGPQLVQCIQWQPA-H-----SPPVLLLKGVGTKC-WA-PEADYGLHA A_carolinensis_ENSACAP00000006055 SCRHPIGHWAD-QTM-HAHLQN-VSYQ-GGQLL-IRQPGKYYVYTQVYFRYPTEGS------------GAQALGHQLVQCVHLQDS-S-----RQNALLLKGVGTKC-WA-KDATYGLHA B_taurus_ENSBTAP00000025281 AVGHKINSWESSRKG-HSFLNN-LYLR-NGELV-ILQTGFYYIYSQTYFRFQEPEEVLGTVST--E--ENRKKIKQMVQYIYKYTN-Y-----PDPILLMKSARNSC-WS-KDSEYGLYS M_musculus_ENSMUSP00000040271 TLGQKIESWESSRKG-HSFLNH-VLFR-NGELV-IEQEGLYYIYSQTYFRFQEAEDASKMVS------KDKVRTKQLVQYIYKYTS-Y-----PDPIVLMKSARNSC-WS-RDAEYGLYS O_anatinus_ENSOANP00000014821 AVGQKINSWESAWKG-HSFKQN-VELR-NGELI-IPRSGFYYIYSQTYFRFLEPEENSESSLV--N--GRTKKSEQMVQYIYKITS-Y-----PEPILLLKSARTSC-WS-KNSKYGLHS C_familiaris_ENSCAFP00000022642 ALGHKINSWDSTRKG-HSFLNN-LHLR-NGELV-IHQRGFYYIYSQTYFRFQEPEEI----PT--G--QNRKRNKQMVQYIYKHTS-Y-----PDPILLMKSARNSC-WS-KDSEYGLYS E_caballus_ENSECAP00000016944 ALGQKINAWETSRKG-HSFLNN-LHLR-NGELV-IHQTGFYYIYSQTYFRFQEPEEILGTVAT--E--ENRRKNKQMVQYIYKSTD-Y-----PDPILLMKSARNSC-WS-KDSEYGLYS T_guttata_ENSTGUP00000011151 GIGHKINNWESSRKG-HSFLYN-VELR-NGELV-IPQTGFYYIYSQIYFRFRENENEDSDLL------GQIRNPKQLVQYVYKLTN-Y-----PEPILLMKSARTSC-WS-KKAEYGLYS G_gallus_ENSGALP00000014937 GIGHKIHSWESSRRG-HSFLYN-VELW-NGELV-VPQTGFYYIYSQTYFRFRENEDEDSGLL------ERIKNPKQLVQYIYKLTN-Y-----PDPILLMKSARTSC-WS-KKAEYGLYS R_norvegicus_ENSRNOP00000017758 TLGQKIETWESSRRG-HSFLNH-VHLR-NGELV-IQEEGLYYIYSQTYYRFKEAKEASKTVS------KDGGRIKQMVQYIYKYTS-Y-----PDPILLMKSARNSC-WS-REAEYGLYS A_carolinensis_ENSACAP00000016126 NLGYKINTWEAPRDS-NSFLYN-VRLN-NGELV-IPQTGVYYIYSQTYFRFHPDSDS-------------VRNPKQMVQYISKYTDYY-----PDPILLMKSARTSC-WS-KKAGYGLYS M_domestica_ENSMODP00000035661 TLGWKIRYWESSRKG-HSFQHN-MDLL-DGELI-VSQPGYYYIYSQTYFRFQESEESSVSTLN--G--EKSKQSKQLVQYIYKVTS-Y-----PEPILLLKSAMTTC-WS-KDSEYGLYS P_troglodytes_ENSPTRP00000026894 ALGHKINSWESSRSG-HSFLSN-LHLR-NGELV-IHEKGFYYIYSQTYFRFQE--------EI--K--ENTKNDKQMVQYIYKYTS-Y-----PDPILLMKSARNSC-WS-KDAEYGLYS D_rerio_ENSDARP00000074299 VYGQKIQSWES-EKG-LAFLQN-VELS-DGELV-VPQAGLYYIYSQTYFRHTLIEEDESAREDEYGSMGESVRGKPMLQYVYKKVSSY-----QVPILLMKNARTTC-WS-RDSEYGLYS H_sapiens_ENSP00000372198 ALGRKINSWESSRSG-HSFLSN-LHLR-NGELV-IHEKGFYYIYSQTYFRFQE--------EI--K--ENTKNDKQMVQYIYKYTS-Y-----PDPILLMKSARNSC-WS-KDAEYGLYS M_mulatta_ENSMMUP00000038711 ALGRKINSWESSRSG-HSFLSN-LHLR-NGELV-IQEKGFYYIYSQTYFRFQE--------EI--K--ENTKNDKQMVQYIYKYTS-Y-----PDPILLMKSARNSC-WS-KDAEYGLYS O_cuniculus_ENSOCUP00000012761 NLGQKISSWESSRKG-HSFLNN-LHLR-NGELV-IHQTGLYYIYSQTYFRFQELEEI--------E--EIKKRNKQMVQYIYKWTS-Y-----PDPILLMKSARNSC-WS-KDSEYGLYS T_rubripes_ENSTRUP00000045419 VQGQKILWWEG-QKG-LAFLQD-VQLV-DGELV-VPWPGLYYVYAQTYFRHTHSLEETEEEGE-----VEGDRGRPLLQYVYKKVNSY-----PVPILLMKTSQTSC-WS-RGSQFSLHS T_rubripes_ENSTRUP00000034053 YLGERIGAWEG-QRG-LSFLQN-MELR-AGELL-VPRAGLYYIYAQTYFRLSSAGETEGEANGD----AAEEDGAHLVQYIYKKMSSY-----TVPILLMKSSRSVC-WP-RGQEPGLFS O_cuniculus_ENSOCUP00000004879 NLGQKISSWESSRKG-HSFLNN-LHLR-NGELV-IHQTGLYYIYSQTYFRFQELEEI--------E--EIKKRNKQMVQYIYKWTS-Y-----PDPILLMKSARNSC-WS-KDSEYGLYS O_latipes_ENSORLP00000014844 YFGERIRAWEG-QRG-LSFLQN-MELR-GGELL-VPRAGLYYIYAQTYFRLASTGDPE------------TEEGAELVQYIYKKMSSY-----MGPILLMKSSRSAC-WP-QGQEPGLFS O_latipes_ENSORLP00000016621 VQGQKISWWDG-QKD-PAFLQE-VQLV-DGELV-VPQPGLYYIYAQTYFRHTLSLEEQGEEGE--------DRGRPLLQYVYKKMSSY-----PVPILLMKTSRTSC-WS-RDSDFSLHS P_pygmaeus_ENSPPYP00000015988 ---RKINSWESSRSG-HSFLSN-LHLR-NGELV-IHEKGFYYIYSQTYFRFQE--------EI--K--ENTKNDKQMVQYIYKYTS-Y-----PDPILLMKSARNSC-WS-KDAEYGLYS G_gorilla_ENSGGOP00000014189 ALGRKINSWESSRSG-HSFLSN-LHLR-NGELV-IHEKGFYYIYSQTYFRFQE--------EI--K--ENTKNDKQMVQYIYKYTS-Y-----PDPILLMKSARNSC-WS-KDAEYGLYS G_aculeatus_ENSGACP00000014440 YLGERIREWEG-HRG-LSFLEN-MELR-GGELL-VPRAGLYYIYGQTYFRLPSSGEAEG-----------GEEEAQLVQYIYKKMSSY-----TVPILLMKSSRSAC-WP-RGPEPGLFS E_caballus_ENSECAP00000014214 --KVSLSSWYH-DRG-WAKISN-MTFS-NGKLK-VNQDGFYYLYANICFRHHETSG------------DLATEYLQLMVYVTKTSIKI-----PSSHTLMKGGSTKY-WS-GNSEFHFYS T_nigroviridis_ENSTNIP00000011552 VQGQKILWWEG-QKG-LAFLQD-VQLV-DGELV-VPWPGLYYVYAQTYFRHTHSLEDAEEEGE-----EEGDRGRPLLQYVYKKVNSY-----PVPILLMKTSRTSC-WS-RGSQFSLHS T_nigroviridis_ENSTNIP00000009448 YLGERIGAWEG-QRG-LSFLQN-MELR-AGELL-VPHAGLYYIYAQTYFRLSSAGETEGEANGE----TAEEDGAQLVQYIYKKISSY-----TVPILLMKSSRSVC-WP-RGQGPGLFS M_musculus_ENSMUSP00000022592 --KVTLSSWYH-DRG-WAKISN-MTLS-NGKLR-VNQDGFYYLYANICFRHHETSG------------SVPTDYLQLMVYVVKTSIKI-----PSSHNLMKGGSTKN-WS-GNSEFHFYS O_anatinus_ENSOANP00000007357 --KVNLSSWYH-DRG-WANISN-MTFS-NGKLR-VNQDGFYYLYANICFRHHETSG------------NLAEESIQLMVYVTKTNVKI-----KKSDTLMKGGSTKS-WS-GSSEFHFYS B_taurus_ENSBTAP00000011745 --KVTLSCWYH-DRG-WAKISN-MTFS-NGKLI-VNQDGFYYLYANICFRHHETSG------------NLSANYLQLMVYVTKTSIKI-----PSSHTLMKGGSTKY-WL-GNSEFHFYS C_familiaris_ENSCAFP00000006955 --KVSLSSWYH-DRG-WAKISN-MTFS-NGKLI-VNQDGFYFLYANICFRHHETSG------------DLATEYLQLMVYVTKTSIKI-----PSSHTLMKGGSTKY-WS-GNSEFHFYS P_troglodytes_ENSPTRP00000009919 --KVSLSSWYH-DRG-WAKISN-MTFS-NGKLI-VNQDGFYYLYANICFRHHETSG------------DLATEYLQLMVYVTKTSIKI-----PSSHTLMKGGSTKY-WS-GNSEFHFYS M_domestica_ENSMODP00000036348 --KVNLSSWYH-DRG-WANISN-MTFS-NGKLR-VNQDGFYYLYANICFRHHETSG------------GLATEFLQLMVYVTKTNVKI-----RNSDTLMKGGSTKH-WS-KKSEFHFYS M_mulatta_ENSMMUP00000023500 --KVSLSSWYH-DRG-WAKISN-MTFS-NGKLI-VNQDGFYYLYANICFRHHETSG------------DLATEYLQLMVYVTKTSIKI-----PSSHTLMKGGSTKY-WS-GNSEFHFYS H_sapiens_ENSP00000239849 --KVSLSSWYH-DRG-WAKISN-MTFS-NGKLI-VNQDGFYYLYANICFRHHETSG------------DLATEYLQLMVYVTKTSIKI-----PSSHTLMKGGSTKY-WS-GNSEFHFYS P_pygmaeus_ENSPPYP00000006060 --KVSLSSWYH-DRG-WAKISN-MTFS-NGKLI-VNQDGFYYLYANICFRHHETSG------------DLATEYLQLMVYVTKTSIKI-----PSSHTLMKGGSTKY-WS-GNSEFHFYS R_norvegicus_ENSRNOP00000013210 --KVSLSSWYH-DRG-WAKISN-MTLS-NGKLR-VNQDGFYYLYANICFRHHETSG------------SVPADYLQLMVYVVKTSIKI-----PSSHNLMKGGSTKN-WS-GNSEFHFYS X_tropicalis_ENSXETP00000054163 --KVNLTFWNF-REG-WANLRN-INYN-NGKLK-ILQDGYYFVYANLCFRHHIHTGK-----------KYRDKALQLMMYICKARKNR-----RPYETLMKGGKTAI-WS-DNSVYHFYS G_gorilla_ENSGGOP00000010907 --KVSLSSWYH-DRG-WAKISN-MTFS-NGKLI-VNQDGFYYLYANICFRHHETSG------------DLATEYLQLMVYVTKTSIKI-----PSSHTLMKGGSTKY-WS-GNSEFHFYS G_gallus_ENSGALP00000027360 --KVNLTSWHH-DKG-QANLSN-MTFS-DGKLI-VNQDGFYYLYANICFRHHETSG------------NLTKRGLQLMVYMTKTNLKI-----RRSDVLMKGGSTKY-WS-GNSEFHFYS T_guttata_ENSTGUP00000012735 --KVNLTSWHH-DKG-QANLSN-MTFN-DGKLI-VNQDGFYYLYANICFRHHETSG------------NLTKRGLQLMVYVIKTNLKI-----RRFDVLMKGGSTKY-WS-GNSEFHFYS A_carolinensis_ENSACAP00000001868 --KVNLTSWHH-DKG-WANVVN-MTFS-DGKLI-ANHDGFYYLYANVCFRHHEAVG------------NLTGQTLQLMVYVRKTDVKR-----KNPVVLMKGGSTKN-WS-GDSEFHFYS O_cuniculus_ENSOCUP00000009507 --KVSLSSWYH-DRG-WAKISN-MTFS-NGKLI-VNQDGFYYLYANICFRHHETSG------------DLATEYLQLMVYVTKTSVKI-----PSSHTLMKGGSTKY-WS-GNSEFHFYS C_familiaris_ENSCAFP00000004996 --LFPALHWEH-ELG-LAFTKNRMNYT-NKFLV-IPESGDYFVYSQVTFRGTTSECGEARQG------SRLNKPDSIIVVITKVTDSY-----PEPTQLLMGTKSVC----EVGSNWFQP E_caballus_ENSECAP00000012153 --QFPALHWEH-ELG-LAFTKNRMNYT-NKFLV-IPEQGDYFVYSQVTFRGTTSECGEIGQG------SRLNKPDSIIVVITKVTDSY-----PEPTQLLMGTKSVC----EIGSNWFQP O_cuniculus_ENSOCUP00000010059 --HFPALHWEH-ELG-LAFTKNRMNYT-NKFLV-IPESGDYFVYSQVTFRGTTSECGVINQR------RRQTKPDSIVVVITKVTDNY-----PEPAQLLTGTKSVC----EMG-NWFQP T_guttata_ENSTGUP00000003285 --HLPILQWED-KRG-LAFTKNNLSYS-SNALV-IPVSGDYYVYAQVTFRGPV---------------ESSHKASSVTEIITKVTDSY-----PEPTQLLTGTKTLS----ENGNGWFQP R_norvegicus_ENSRNOP00000011845 --ELAALHWEN-NLG-MAFTKNRMNYT-NKFLV-IPESGDYFIYSQITFRGTTSECGDISRV------RRPKKPDSITVVITKVADSY-----PEPAHLLTGTKSVC----EISSNWFQP G_gallus_ENSGALP00000039261 --HLPILQWED-KRG-LAFTKNNLSYS-SNALV-IPVSGDYYVYAQVTFRGPS---------------DTSSKTSSVTAVITKVTDSY-----PEPTQLLTSTKTLS----EERNNWFQP P_troglodytes_ENSPTRP00000036375 --QFPALHWEH-ELG-LAFTKNRMNYT-NKFLL-IPESGDYFIYSQVTFRGMTSECSEIRQA------GRPNKPDSITVVITKVTDSY-----PEPTQLLMGTKSVC----EVGSNWFQP M_mulatta_ENSMMUP00000016931 --QFPALHWEH-ELG-LAFTKNRMNYT-NKFLL-IPESGDYFVYSQVTFRGMTSECSEIRQA------GRPNKPDSITVVITKVTDSY-----PEPTQLLMGTKSVC----EVGSNWFQP M_musculus_ENSMUSP00000050144 --QLSALHWEH-DLG-MAFTKNGMKYI-NKSLV-IPESGDYFIYSQITFRGTTSVCGDISRG------RRPNKPDSITMVITKVADSY-----PEPARLLTGSKSVC----EISNNWFQS M_domestica_ENSMODP00000024427 --SWPALQWEH-KLG-SAFVKNQMNYT-NKFLV-IPESGDYFVYSQVTFRGSTPECGKINQK------DRSTKPDYITQVITRVTDRY-----PEPTQLLTGTKSIC----EIGSNWFIP H_sapiens_ENSP00000363157 --QFPALHWEH-ELG-LAFTKNRMNYT-NKFLL-IPESGDYFIYSQVTFRGMTSECSEIRQA------GRPNKPDSITVVITKVTDSY-----PEPTQLLMGTKSVC----EVGSNWFQP B_taurus_ENSBTAP00000036310 --QFPALHWEH-ELG-LAFTKNRMNYT-NKFLV-IPESGDYFVYSQVTFRGTTSECGEISQG------RRPNKPDSIIVVITKVTDSY-----PEPTQLLMGTKSVC----EIGSNWFQP G_gorilla_ENSGGOP00000010545 --QFPALHWEH-ELG-LAFTKNRMNYT-NKFLL-IPESGDYFIYSQVTFRGMTSECSEIRQA------GRPNKPDSITVVITKVTDSY-----PEPTQLLMGTKSVC----EVGSNWFQP X_tropicalis_ENSXETP00000052879 --KEAVLQWME-KGY-SSMCKQ-ITYT-NGKLK-VEKAGIYYVYSQVSFCMN----------------SPQQSRAPFVQYIYLSRPQ------ETDKLLLKGANTFI--T-PTPNCALHS P_pygmaeus_ENSPPYP00000021893 --QFPALHWEH-ELG-LAFTKNRMNYT-NKFLL-IPESGDYFIYSQVTFRGMTSECSEIRQA------GRPNKPDSITVVITKVTDSY-----PEPTQLLMGTKSVC----EVGSNWFQP D_rerio_ENSDARP00000075321 VPALDRIHWDN-MNG-QFIQEGLMRLSPDGEIV-VPLNGIYFVFSQVNFETQ------------------LGQNVHFTQYLYKRTASY-----PRPVMLSKAAVTPC-SS-VRSGVQLYT O_anatinus_ENSOANP00000016821 --QFPILLWEH-DLG-LAFIKNRMNYT-NKFLV-IPESGDYFVYSQVTFRGTTPECGKITQL------NRSSKPDYITQIITKVTDSY-----PEPTKLLTGTKSVC----EIGSSWFQP O_anatinus_ENSOANP00000001418 --TSILLEWED-TLG-HAFVSG-VKYK-NHGLE-INDTGLYFVYSKVYFRSR------------------DCSNKALSHTVFKRNPNY-----PKDLVLMEGKKTN--YC-SLSQMWAHS M_domestica_ENSMODP00000017609 --STAVLQWAR-KGY-YTMSDS-LSYS-DGKLT-VQSSGFYYLYSQVTFCSN----------------REASSQAPFIVSLHLKSS-------ESERVLLRAANTHT----PSKPCGHQS M_domestica_ENSMODP00000032553 --NGGPLLWEA-HLG-LAFLRD-LKYQ-KGSLV-CTQPGYYYIYSKVQLGGVGCP-------------GGPMAGGSVTHGLYKRTPRY-----PKDLELLVSRRSSCRWTGTSAKVWWDS T_rubripes_ENSTRUP00000014782 --NAVTIIWDQ-VHG---YRHH-MGYQ-KGKLL-VMESGFYYVYAKTCFRYYKYLPEDSIQVAVP---TVDVSNTQLIQYIFHESIKQN----SKAVVLMKTGSTMR-W--NNASYNMYC T_guttata_ENSTGUP00000002174 --AGSVLEWRE-TMY-GPTNSL-ISNK-EGKLK-VEEAGLYYIYSQVSFCTP----------------EV--SLAPFTLYIYLHIPK------EEDRLLLKGQKTQS--S-LKTLCELQS A_carolinensis_ENSACAP00000003654 -----------------------ITYS-DGYLT-VPETGDYFVYTQVSYRCPD-----------------GKNKTIITQIISKISSSYG----SEPKQQLITSTSI-----GEKEMWKKT O_anatinus_ENSOANP00000018492 --SASVLQWMK-KGR-FTMSHL-LSYK-AGKLT-VERPGLYYIYTQVGFCSK----------------DVATEKEPFVTYLYLSQKS------GAVSPLLKGANSQT----STQHCGLQS T_nigroviridis_ENSTNIP00000014509 --NAVTIIWDQ-DHG---FCNR-MNYQ-KGKLL-VVESGFYYVYAKTCFRYYKYLPEDSVQAAVP---TVDVSNTQLIQYILYESIKQN----SKAVVLMKTGSTMR-W--NNTSYNMYC X_tropicalis_ENSXETP00000056100 VSKDQALQWEN-SNG-LAFTNNGMNYT-NEGLE-IPKTGYYFVYSQVTFRLPTYTA------------GKKSKTEHVSLTVKKITSKY-----PEPEKLISGAKNVN----ENESEGYRP 370 380 390 400 410 420 430 =========+=========+=========+=========+=========+=========+=========+== D_rerio_ENSDARP00000038477 IYQGGLFELRAGDEIFISVSSPTAVYAEDS-SSYFGAF-------------------LF---D--------L T_rubripes_ENSTRUP00000014307 VYQGGLFELRAGDELFVSVSSPTMVNADDS-SSYFGAF-------------------RL---D--------L D_rerio_ENSDARP00000022037 VYQGGLFELRAGDEVFVSVSSPTMVYGEDS-SSYFGAF-------------------RL---D--------L O_latipes_ENSORLP00000010677 VYQGGLFELRAGDELFVSVSSPTMVNADES-SSYFGAF-------------------RL---D--------L O_anatinus_ENSOANP00000022049 VYQGGLFELRAGDELLVSVSTPAIDYTDGA-ASYFGVF-------------------RL---D--------V G_gallus_ENSGALP00000011699 LYQGGLFELKAGDELFVSVSSLAIDYSEGA-ASYFGAF-------------------RL---D--------L T_nigroviridis_ENSTNIP00000008505 VYQGGLFELRAGDELFVSVSSPTMVNADDS-SSYFGAF-------------------RL---D--------L X_tropicalis_ENSXETP00000048879 VHQGGIFELRSGDELFVSVSSLDMVYADST-SNFFGAF-------------------KL---S--------L T_guttata_ENSTGUP00000005543 LYQGGLFELKAGDELFVSVSSLAIDSNDAA-ASYFGAF-------------------RL---D--------L A_carolinensis_ENSACAP00000006055 LYQGGLFDLRAGDRLFVSVSTLDINDGDEA-GSYFGAF-------------------RL---D--------G B_taurus_ENSBTAP00000025281 IYQGGIFELKENDRIFVSVTNERLVDLDQE-ASFFGAF-------------------LI------------G M_musculus_ENSMUSP00000040271 IYQGGLFELKKNDRIFVSVTNEHLMDLDQE-ASFFGAF-------------------LI------------N O_anatinus_ENSOANP00000014821 IYQGGVFEFKQNDRIFVSVSNESMIDMDKE-ASFFGTF-------------------LI------------G C_familiaris_ENSCAFP00000022642 IYQGGIFELKENDRIFVSVSNEQLIDMDQE-ASFFGAF-------------------LI------------G E_caballus_ENSECAP00000016944 IYQGGIFELKENDRIFVSVTNEQLIDMDQE-ASFFGAF-------------------LI------------G T_guttata_ENSTGUP00000011151 IYQGGVFQLKREDRIFVSVSNSDIVDMDKE-ASFFGAF-------------------MI------------S G_gallus_ENSGALP00000014937 IYQGGVFQLKREDRIFVSVSNSDIVDMDKE-ASFFGAF-------------------MIVKRQKTVLWRKQS R_norvegicus_ENSRNOP00000017758 IYQGGLFELKENDRIFVSVTNEHLMDLDQE-ASFFGAF-------------------LI------------N A_carolinensis_ENSACAP00000016126 IYQGGVFQLNMNDRIFVSISNKDLVDMDKP-ASFFGAF-------------------LV------------S M_domestica_ENSMODP00000035661 IYQGGVFEFREKERIFVSVSNEKLVDMDKE-ASFFGAF-------------------RI------------G P_troglodytes_ENSPTRP00000026894 IYQGGIFELKENDRIFVSVTNEHLIDMDHE-ASFFGLFSWLTDLERKSNN-LKVTIQFS------------G D_rerio_ENSDARP00000074299 IYQAGLFQLGSGDRVFVTVSNVSTIDMDEK-SSFFGAF-------------------LV------------S H_sapiens_ENSP00000372198 IYQGGIFELKENDRIFVSVTNEHLIDMDHE-ASFFGLFSWLTDLERKSNN-LKVTIQFS------------G M_mulatta_ENSMMUP00000038711 IYQGGLFELKKDDRIFVSVTNEHLIDMDHE-ASFFGLFGWLTDLERKSNN-LKVTIQFS------------G O_cuniculus_ENSOCUP00000012761 IYQGGIFELKENDRIFVSVTNEQLIDMNQE-SSFFGLFDWLNDLQRKKSNLLKVTICSS------------G T_rubripes_ENSTRUP00000045419 AHQGGLFPLGSGDRLFVTVTNATAVDMDEK-SSFFGAF-------------------LV------------S T_rubripes_ENSTRUP00000034053 LHQAGTAFLQPADRLFITVSNASTMEMDGR-ASYFGAF-------------------LV------------G O_cuniculus_ENSOCUP00000004879 IYQGGIFELKENDRIFVSVTNEQLIDMNQE-SSFFGFFDWLNDLQRKKSNLLKVTILFS------------G O_latipes_ENSORLP00000014844 LHQAGTAFLQPADRLFITVSNASAVEMDGR-ASYFGAF-------------------LV------------S O_latipes_ENSORLP00000016621 AHQGGLFSLSTGDRLFVTVTNASAVDTDRG-GSFFGVF-------------------LV------------S P_pygmaeus_ENSPPYP00000015988 IYQGGIFELKENDRIFVSVTNEHLIDMDHE-ASFFGLFSWLTDLERKRSN-LKVTIQFS------------G G_gorilla_ENSGGOP00000014189 IYQGGIFELKENDRIFVSVTNEHLIDMDHE-ASFFGLFSWLTDLERKSNN-LKVTIQFS------------G G_aculeatus_ENSGACP00000014440 LHQAGTAFLQPADRLFVTVSNVSAMEMDGR-ASYFGAF-------------------LV------------G E_caballus_ENSECAP00000014214 INVGGFFKLRSGEEISIEVSNPSLLDPDQD-ATYFGAF-------------------KVRDID--------- T_nigroviridis_ENSTNIP00000011552 AHQGGLFPLGSGDRLFVTVTNATAVDMDEK-SSFFGAF-------------------LV------------S T_nigroviridis_ENSTNIP00000009448 LYQAGTAFLQPADRLFITVSNASTLEMDGR-ASYFGAF-------------------LV------------G M_musculus_ENSMUSP00000022592 INVGGFFKLRAGEEISIQVSNPSLLDPDQD-ATYFGAF-------------------KVQDID--------- O_anatinus_ENSOANP00000007357 VNVGGFFKLRSGEEISIQVSNPSLLDPAQD-ATYFGAF-------------------KVRDID--------- B_taurus_ENSBTAP00000011745 INVGGFFKLRSGEKISIEVSNPSLLDPDQD-ATYFGAF-------------------KVRDID--------- C_familiaris_ENSCAFP00000006955 INVGGFFKLRSGEEISIEVSNPSLLDPDQD-ATYFGAF-------------------KVLDID--------- P_troglodytes_ENSPTRP00000009919 INVGGFFKLRSGEEISIEVSNPSLLDPDQD-ATYFGAF-------------------KVRDID--------- M_domestica_ENSMODP00000036348 INIGGFFKLRSGEEISIQVSNPSLLDPAQD-ATYFGAF-------------------KVRDID--------- M_mulatta_ENSMMUP00000023500 INVGGFFKLRSGEEISVEVSNPSLLDPDQD-ATYFGAF-------------------KVRDID--------- H_sapiens_ENSP00000239849 INVGGFFKLRSGEEISIEVSNPSLLDPDQD-ATYFGAF-------------------KVRDID--------- P_pygmaeus_ENSPPYP00000006060 INVGGFFKLRSGEEISVEVSNPSLLDPDQD-ATYFGAF-------------------KVRDID--------- R_norvegicus_ENSRNOP00000013210 INVGGFFKLRAGEEISVQVSNPSLLDPDQD-ATYFGAF-------------------KVQDID--------- X_tropicalis_ENSXETP00000054163 VYQGGVFKLHAGEEIFIQASYSELLDPAQE-ATYFGAF-------------------KIPSLD--------I G_gorilla_ENSGGOP00000010907 INVGGFFKLRSGEEISIEVSNPSLLDPDQD-ATYFGAF-------------------KVRDID--------- G_gallus_ENSGALP00000027360 VNIGGFLKLKTGDMISIQVSNPLLLDSSQE-ATYFGAF-------------------KVRDLD--------- T_guttata_ENSTGUP00000012735 VNVGGFFKLKSGEMISIQVSNPSLLDSSQE-ATYFGAF-------------------KVRDLD--------- A_carolinensis_ENSACAP00000001868 VNVGGFFKLKSGEVVSIQVSHPSLLDRSPE-GTYFGAF-------------------KVRDID--------- O_cuniculus_ENSOCUP00000009507 INVGGFVELRSGEEISVEVSN--------------------------------------------------- C_familiaris_ENSCAFP00000004996 IYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAF-------------------LL------------- E_caballus_ENSECAP00000012153 IYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAF-------------------LL------------- O_cuniculus_ENSOCUP00000010059 IYLGAMFSLEEGDKLMVNVSDVSLVDYTKEDKTFFGAF-------------------LL------------- T_guttata_ENSTGUP00000003285 IYLGAVVSLEVGDKLMVNVSDIKLVDYTKEHKTFFGAF-------------------LL------------- R_norvegicus_ENSRNOP00000011845 IYLGAMFSLEEGDRLMVNVSDISLVDYTKEDKTFFGAF-------------------LI------------- G_gallus_ENSGALP00000039261 IYLGAVVSLEIGDKLMVNVSDIKLVDYTKEHKTFFGAF-------------------LL------------- P_troglodytes_ENSPTRP00000036375 IYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAF-------------------LL------------- M_mulatta_ENSMMUP00000016931 IYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAF-------------------LL------------- M_musculus_ENSMUSP00000050144 LYLGATFSLEEGDRLMVNVSDISLVDYTKEDKTFFGAF-------------------LL------------- M_domestica_ENSMODP00000024427 IYLGAVFPMQEGDKLMVNVSDISLVDYTKEDKTFFGAF-------------------LL------------- H_sapiens_ENSP00000363157 IYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAF-------------------LL------------- B_taurus_ENSBTAP00000036310 IYLGAMFSLNEGDKLMVNVSDISLVDYTKEDKTFFGAF-------------------LL------------- G_gorilla_ENSGGOP00000010545 IYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAF-------------------LL------------- X_tropicalis_ENSXETP00000052879 LQQGAVFALKENDLLFVNVTDSSLVNYSPG-LTYFGMF-------------------KL------------- P_pygmaeus_ENSPPYP00000021893 IYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAF-------------------LL------------- D_rerio_ENSDARP00000075321 NHQGALFRLQKGDRLSLYVLDTRAVRFPQE-ATYFGAF-------------------MI------------K O_anatinus_ENSOANP00000016821 IYLGAVFSMQEGDKLMVNVSDISLVDYTKEDKTFFGAF-------------------LL------------- O_anatinus_ENSOANP00000001418 SYLGAVFNLTRADRLYVNVSEPKLVYFQES-ETFFGLY-------------------KL------------- M_domestica_ENSMODP00000017609 IRLGGTFDLQQGASVFINVTDPTQVSHGPG-FTYFGLF-------------------KL------------- M_domestica_ENSMODP00000032553 SFLGGVVHLEAGEEVFVRVPEERLVRVKDGTRSYFGAF-------------------MV------------- T_rubripes_ENSTRUP00000014782 AQQGRGVHLEKGDALFVNVSNAWMLDPEGE-GTYFGAI-------------------KL----G-------N T_guttata_ENSTGUP00000002174 IRVGGVFNLREDDMVFVNVTDSTKVRYSHG-NTYFGIF-------------------KL------------- A_carolinensis_ENSACAP00000003654 LYLGGILELRERDKLMVNVSNPELVDIALPAMTFFGAF-------------------LI------------- O_anatinus_ENSOANP00000018492 IHIGGVFDLQQGVSVFVRVTKSSQVFYDSE-LTYFGLI-------------------KL------------- T_nigroviridis_ENSTNIP00000014509 AQQGRGVRLETGDALFVNVSNAWMLDPEGE-GTYFGAI-------------------KL----G-------H X_tropicalis_ENSXETP00000056100 IYLGALLLLEAKDQLIVEVSDIQLVDVTVEHKTFFGAF-------------------ML-------------