>D_melanogaster_FBpp0113052 ------------------------------------------------MAGSNLLIHLDT IDQNDLIYVERDMNFAQKVGLCFLLYGDDHSDATYILQKLLAMTRSDFPQSDLLIKF--- ----AKSRPETWRRHLVEALCIIGARKVLRRLGFCWQELRMHYLPHIA------------ ------------------------------------------------------------ -----------------------------------------------GITLHVHPLLKSL YRMCEELSLVQSGRLLLDVREKVESQQAGDPLRFYDPAYLEIFLLDWLTRRSI------- --------KL-GDINAAGSDVQLLVGHLKSNGLQAQANLL-------------------- ------------------------------------------------------------ ----------------------------------KDTIISNAPEPDAAGTAAMAVKQE-- -------------------------------------------------------IESDN QQSYCSTQIDALK--LTRENAGIALIINQQKFHRNVSRDNMKFLSPDPLRRRDGT-DVDK ERL-IEVFSSMGYNVEAYDNVDHMGIIERIRSACDR---SLVRDSLVVFILSHGFE---- ---E-AVYASNSIAMKITDIEDLLCSY--DTLYYKPKLLIIQ--ACQEKLV-HKKKPNEL ----------------------------FRI-----------DVTTVSPD-----QHIDM LRAMSTVN--GYAALRHTQTGSWFIGSLCDAIDRRSA-S------EHIA----------- DILTIVTNEVSKKRGS--------NDESMVPNVKSTFRQHVYFP--PR---L-------- --------- >A_aegypti_AAEL014148-PA --------------------------------------------------------MSIS IQLEDLDFIEEELHFDDKVAVLFLLYG--HRNPKYVLQLLTVAIRAPDAR-TQFLSEWAN LVAKGEVSASRWQSELLEALAIVQANLCLLKCGFDDEELRAQFLPHVP------------ ------------------------------------------------------------ -----------------------------------------------ELATHVHPVLKGL WMLCEKMDKATCGRLENYLMQNYA-------LTVTDSEFLEMVMLDMIGQGVI------- --------KLGSKEDGQVSDLSNLIAAFKALELEGLKDFCKNIESNFNRDLQSG--ENQS ------------------------------------------------------------ ----------------------------------DNAKSTLVAEVKRQ------------ ------------------------------------------------------------ -SVDNSDHLEKYV--ISWKNAGLILIVNQFQFFRDSNPELADLIPSEPLKNRRGT-EVDK MAI-LNLFTNLGYEPIVVENIPHLEIMNQVEQAVDR-V-EPHHCSLVICLLSHGQE---- ---G-KVYGSNSIPVSVKAIERKMAA---RKLTGKPKLLFVQ--ACQGSGL-QTAVDVAP RLEH------------------------DG------------PSSETTAS-----VFVDF LVAWSTVP--GFASIRHIEKGSWFIQELCSKIRQLYE-R------DHLM----------- DILTAVINDVSAKRG--------YENECMVPIIYTTLRKKLYFE--AL---KVK------ --------- >A_gambiae_AGAP011693-PA ---------------------------------------------SYQNVNKQKNPPQQM LSQEDVNFIENSLSFEEKASVIFLLYG--QRNPQYALQILTVAGRAPEGEETNFLVDWMN HVPQAE----SWENELLEALTIMEQNLLLLQAGFDDAELRAKYFPQTA------------ ------------------------------------------------------------ -----------------------------------------------EIALHVHPMLKGL YHFCERLSDENAQKLVIQLQQSTT-------FAPLRHECMEIILLQLLINGNI------- --------ELGLKQSGVESNVLLLTAACKAAELYDESDFLKSIASHYNRNVSQP--NREQ ------------------------------------------------------------ ----------------------------------SDATAKHIPKVDDSPNSHARSNIP-- ---------------------------------------------------------LPS VVQPVTSSLESYT--FDPARAGTVLLINQFTFYRETNPELVELVPSRPLKDRKGT-EVDK SAL-ERLFNDFGYDLLVEENITHHQILQAVQHAVQR-T-QPIHCSLVVCLLSHGQE---- ---G-KVFGANSIPVEVRAIQQLMAS---ERLTGKPKLLIVQ--ACQGADL-QSAVPVPI -YEH------------------------DGL-----------EGSEKTAS-----VFMDF LVAWSTVP--GFASIRHIEKGSWFIQELCAKLRQLYR-R--------------------- ------------------------------------------------------------ --------- >T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MSANGPASGEDF--TDAS KG-GEQP----------------------------------------------------- ----------------------------------SGSSSSGKMTVDA------------- ------------------------------------------------------------ ---KSARYSFRYS--LDFPNLGHCIIINNKNFDRR-----------TGMNTRNGT-DVDA ANA-MKVFSNLGYRVRVHNDQTVAQISQLLTSAAKE-D-HSRCASFVCILLSHGDE---- ---G-VLYGTDG-PMEIKSLTSLFRGDRCRSLVGKPKLFFIQ--ACRGNDL-DGGIETDS ---------IE-------------------------------DNSTTKIP-----VEADF LYAFSTAP--GYYSWRNTMSGSWFMQSLCDTISKYGK-E------LELQ----------- HILTRVNHKVAVEFESDSSL-PGFNAKKQIPCIVSMLTKEMYFS---------------- --------- >X_tropicalis_ENSXETP00000008971 -----------------------------------------------------------M DFNSMLLSIDDGLGREDIEALKFLCRD--VLRKNKLLSVRSGQELFQQLMTEDLINE--- ----------DNFFLLKELLYIINHHSLLRN-LGTNKEKVQKALPR-------------- -----------------------------------------QGRISPY------------ --------------------------------------------------------RQML YQLSENIAGDDEKRVYFLLP-----------LQKKHKENKT--FLEVLCQLER------- --------EN-SITEDDVELLEDIFKK-VAPDLLKIIEKYKERGDKLHQTENHL--IDPS APPEDEHELINPPLSIQVSSKDS------------------------------------- ---------------ELWDKGTESLIEHTGMIHEEAEKEDDKSGNINHQLSDLRLNSE-- ------------------------------------------------------------ -MTPQANKEEFYD--MNHKHRGYCLIIDNSVFMKG--------------NRREGS-DKDA GAL-SDVFSWLGLEVDIFENLMSEQIRDCLKRFKSR-D-HSERDCFVCCILTHGES---- ---G-TVMGSDDKEVSIREIMSYFTAISCTSLVLKPKLFFIQ--ACQGKFT-HPSSKVEA --DAIVPEEN--------------------------------KKYVVNVP-----KDADF LLGMSTVD--GYAAYRHTREGSWYIQALCKNLVELVP-RG-----EDIL----------- AILTKVNKDVSLKEG-------QQGILKQMPQPSYTLLKKLRF---PV---PDVPFRPKT CQENSP--- >C_familiaris_ENSCAFP00000017933 ------------------------------------------MTSQAQSLTFRSDDNCQS SFRGKLLTIDSKLEIQDVEGLKFLCRD--FVSHKKLEKSNSASDIFDHLLAEELLSE--- ----------EDPFFLAELLYIIKQNSLLRY-LNQSKEQVESLLPT-------------- -----------------------------------------RRRVSLF------------ --------------------------------------------------------RNLL YELSESIGSENLKDMIFLQRDSM--------PKTQLT------PLSFLAYLEK------- --------QA-LIDEDNLGLLEDLCRK-VVPNLIRKIERYKREKASEVVTPPVD--TETE SLHQKEEELFSPSDINQFHGALS------------------------------------- --------------------KQTSWNPLKHRAKQGNIISDGATLVSVEMLEASTGPLT-- ------------------------------------------------------------ -SETSTKEANVYR--MDRKHRGHCVIVNNHTFAK--------------MPDRPGT-DKDA ECL-SRVFQWLGFSVHVYKNVTKGHLDEVLQEFKCHPD-HVDGDCFVFCVLTHGKF---- ---G-AVYSSDGTLVPIREIMSHFTAQKCPGLAHKPKLFFIQ--ACQGKGI-QTPVSIEA --DAVNPEHVS-------------------------------PSLKDSIP-----DAADF LLGLATVP--GYVSFRHVEKGSWYIQSLCNRLKSLVP-RH-----EDIL----------- SILTAVNNDVSQQAD-------KQGTMKQMPQPAYTLRKKLVF---PV---PQKELLL-- --------- >M_domestica_ENSMODP00000005560 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MEDTGTT--VDAK SIKNS------------------------------------------------------- ----------------------------------GVKSLHSSKSVE-------------- ------------------------------------------------------------ ---SGLS-SDSYK--MDYPEMGLCVIINNTHFHND-----------TELSPRTGS-DKDA ANL-IDIFRSLKYEVRNKNNLTRDKMIELLRQVSEE-D-HSQRSSFVCVILSHGEE---- ---G-VIFGTDD-SVELKELTYFFKGYKCKSLTGKPKLFIIQ--ACQGREF-DCGVETDS ---------GTD----------------E-------------DVACHKIP-----VEADF LYAYSTVP--GYYSLRDPKDGSWFIQALCAVLKQHAH-K------LEIM----------- QILTRVNRKVATEFESYSSK-ASLHAKKQMPCIMSMLTKELYFSH--------------- --------- >O_cuniculus_ENSOCUP00000003895 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------NSLHLLEHLEK------- --------RD-DIHEDNLTYLEDLCKK-VAPSLMRIIEKYKNEKXXXXXXXXXX--XXXX XXXXXXXXXXXXXXXXXXXXXXV------------------------------------- ----------------------------------------TPALASVELLRAPADFLR-- ------------------------------------------------------------ -LETSTREANVYR--MDRKHRGRCVIVNNEIFTTY-------------LSDRRGT-QRDA EQ--KLVFQWLGFKVHKCDNKTKEDLEALLQEEKHHPD-HDDGDCFVFCVLTHGIF---- ---G-AVYSSDGVLIPIREIVSHFTAKQCPGLAGKPKLFFIQ--ACQGKEI-QSSAPIEA --DAVNPECVP-------------------------------PSLQDSIP-----VEADF LLGLATVP--GYASLRHVENGSWYIQSLCNHLKALVP-H------EDIL----------- SILTAVNNDVSRQAD-------KSGRMRQMPQPAFTLRKRLVF---PV---PQEEPSF-- --------- >O_latipes_ENSORLP00000010793 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MDMAETAEELSGKDQ--VDTK PVISKR------------------------------------------------------ ----------------------------------SPANQPNPRSTDVC------------ ------------------------------------------------------------ -VIKQDADPYRYS--MDYPKMGICLIINNKNFHKD-----------SGMGPRNGT-DNDA AAA-WKSFMKLGYEIQMYNDQTVDQMKKLFRQMSNQ-D-HSKFASFACVILSHGEE---- ---G-VIYGTDG-PVSFNKLIECLKGRSCLSLVGKPKLFFIQ--ACRGTLF-DEGIEHDA ----------------------------K-------------DDTSEKIP-----LEADF LFAYSTVS--GYYSWRSTANGSWFIQSLCEMLEKFSK-T------LDLM----------- QIMTRVNHKVATHFESSSNA-PGFSGKKQIPCIVSMLTKDFYFPYESN------------ --------- >D_rerio_ENSDARP00000006831 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MNGDC--VDAK RVDTTDASK--------------------------------------------------- ----------------------------------DGASASQPMQVDA------------- ------------------------------------------------------------ ---KPQSHAFRYS--LNYPNIGHCIIINNKNFDRR-----------TGMNPRNGT-DVDA GNV-MNVFRKLGYIVKVYNDQTVAQIMQVLTTVAHD-D-HSRCASLVCVLLSHGDE---- ---G-VFFGTDT-SVDLKSLTSLFRGDRCPSLVGKPKLFFIQ--ACRGTEL-DPGVETDH ---------PDHPDI---------------------------PDGRVRIP-----VEADF LYAYSTVP--GYYSWRNTMTGSWFIQSLCEMMTKYGS-E------LELL----------- QIMTRVNHKVALDFESTSNM-PGFDAKKQIPCIVSMLTKEMYFT--P------------- --------- >O_anatinus_ENSOANP00000005531 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------YR--MNRAHRGYCIIFNNYTFKGK-------------LNSRKGT-QKDV AEL-ERVFRWLGLDVETFNDKSRQEMVATLEECSRRPD-HDVRDCLVCCVLSHGES---- ---G-AVYSADEELIPIRQIMSYFTAKDCPSLAHKPKLFFIQ--ACQGKDI-QEAVQIEP --DARNPDLDPQPEPPPAP---------R-------------ESPKDSIP-----AEVDF LLGMATVD--GYASFRHVNQGTWYIQALCRQLALLVP-RR-----EDIL----------- SILTAVNDDVSQRAD-------HLGKKKQMPQPAFTLRRKLVF---P------------- --------- >M_musculus_ENSMUSP00000027189 -----------------------------------------------------------M DFQSCLYAIAEELGSEDLAALKFLCLD--YIPHKKQETIEDAQKLFLRLREKGMLEE--- ----------GNLSFLKELLFHISRWDLLVNFLDCNREEMVRELRDPD------------ -----------------------------------------NAQISPY------------ --------------------------------------------------------RVML FKLSEEVSELELRSFKFLLNNEI--------PKCKLEDDLS--LLEIFVEMEK------- --------RT-MLAENNLETLKSICDQ-VNKSLLGKIEDYERSSTERRMSLEGR--EELP PSVLDE------------------------------------------------------ ----------------------------------MSLKMAELCDSPREQ----------- ------------------------------------------------------------ -DSESRTSDKVYQ--MKNKPRGYCLIINNHDFSKA----REDITQLRKMKDRKGT-DCDK EAL-SKTFKELHFEIVSYDDCTANEIHEILEGYQSA-D-HKNKDCFICCILSHGDK---- ---G-VVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQ--ACQGSNF-QKGVPDEA --GF------EQQNHTLEV---------D-S-----------SSHKNYIP-----DEADF LLGMATVK--NCVSYRDPVNGTWYIQSLCQSLRERCP-QG-----DDIL----------- SILTGVNYDVSNKDD-------RRNKGKQMPQPTFTLRKKLFF---PP------------ --------- >T_rubripes_ENSTRUP00000024467 ------------------------------------------------------------ MDLRLLSQIDAQLDSLEVAALCFLCRD--AVSPKSREGITDARGLFKKLHEKRLL----- ----------ENSSFLSQLLHTIHRKDLLCLLEADSSQPEETDA---------------- -----------------------------------------RPLLSEY------------ --------------------------------------------------------RVML YKLYENLDREDLKKLKFLLSDQL--------GRRQIELCKT--VLDVFTEMEK------- --------KG-LLSNTKLDKLHSVLKE-VDQRLAATVHDFMQPLRGILVPRGPG--TPPP AVMSMVIPV--------------------------------------------------- ----------------------------------RLAVPETQS---RGTEQNVSPDAE-- ---------------------------------------------------------SIF QSSPPADDNEYYA--LIHNPRGLCVVFNNETFLPG-----------ANLPRRGGT-MEDQ KRL-RSVFTKFGFTVQVHNDFTAEAILRELKRLGKR-D-FMNEDALVVCVLSHGLK---- ---G-CIFGTDGEEVSLQDFTQPFVSSQAPTLAGKPKLFFIQ--ACQGEKL-QKGYAAWP ---PRPEQEMAKAESQLEE---------DAG-----------PVKAKVVA-----DSADF LIGMATVE--DYKSFRNTKNGSIYIQELCNQLQKSAESPGH----DHIL----------- DILTRVNREVSEGEF---------LNHKQMPEPKYTLTKKLVLK--YL------------ --------- >X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MEESHNGVQYGEDT--ADAK TYFTN------------------------------------------------------- ----------------------------------QQISLQNCDIKDME------------ ------------------------------------------------------------ -KKTKFAHLHKYR--TDYPEMGICLIINNKNFQSS-----------TNMGVRNGT-DVDA RKL-HETFTGLGYKVKVCNDQKSNDIFTLLKKMSEE-D-HSKRSSFVCAILSHGED---- ---G-LVYGVDG-PIQIKNLTDLFRGDRCKTLVGKPKLFFIQ--ACRGTDL-DSGIETDS ---------GSE----------------P-------------GEEIQRIP-----VEADF LYAYSTVP--GYYSWRNTMNGSWFIQSLCEMIKLYGP-H------LELI----------- QILTCVNHMVALEFESCSTQ-QAFHAKKQIPCVVSMLTKAFYFLK--------------- --------- >T_guttata_ENSTGUP00000010625 ------------------------------------------------------------ DFRKLLFEVSEALVTEELSALKFLSLD--HVPRRKLEAIHEPKAFFEVLQEKDMIGA--- ----------GNLFFLKELLYRIHRIDLLSTPLGCSREEMERELQLPG------------ -----------------------------------------RAQVSAY------------ --------------------------------------------------------RQLL YGIAEDLTSEDVRSVKFLLQKQL--------PKNKLQENAS--MLQVFLEMEI------- --------KG-IIKEDNMTTLKDILQR-FRADIKKKIDAYEEKKKGLTGSAEVS--LELP VSWIDS------------------------------------------------------ ----------------------------------VDHIKQSTLGLPGED----------- ------------------------------------------------------------ -RSLSFQLLEAYK--MTSRPCGVCLILNNHNFAKA----REGVLEHKHMKDRNGT-DVDA AAL-RNVFSKLHFRVEEYRDLTAEEIRETVNIFQSA-D-HEDKDCFVCCILSHGKK---- ---G-IIYGVDGQEVPIRELTTSFTAQNCSSLAGKPKVFFIQ--ACQGDAF-HKGVAIET --DS------VEEDSSLER---------D-A-----------RFQLDCIP-----AEADF LLGMATLQ--DYVSYRSPKEGTWYIQALCQHLEYSCP-RG-----EDVL----------- TILTAVNQEVSKKTC-------ERDAKKQMPQPSFTLRKRLIF---PV---N-------- --------- >E_caballus_ENSECAP00000021726 ------------------------------------------MTSQGQNLNSSSDDNCTM DFRQKLLFIDSHLGDQDVERLRFLCRD--CVSHKKLEKSSSALEIFNHLLAEDLLRE--- ----------EDSFFLAELLYIIKQKSLLCH-LCYTKEQVESLLPA-------------- -----------------------------------------RRRVSLF------------ --------------------------------------------------------RNLL YELSEGMDSDNLNSMMFLLKDSI--------PKTQMT------SLSLLAHLEK------- --------QA-RIDEDNLTLLEMLCKN-VVPNLMRKIEKYKREKAAQVVTAPVD--KETE SLHHGEEELFSRSDIKKFSRALP------------------------------------- -------------------------QPWEHTHAGLGSLPLGNSRVSKGWSSALASGIG-- ------------------------------------------------------------ -SISSSKETPLYR--MDRTHRGHCVVVNNHTFTS--------------LADRPGT-DKDA ECL-KSVFQWLGFSVHRYDNVTKEGLEKVLQEYRNHPG-HASGDCFVFCVLTHGKF---- ---G-AVYSSDGILIPIREIMSHFTAQRCPALAHKPKLFFIQ--ACQGEEV-QPSVSIEA --DAVNPENVT-------------------------------PSLEDSVP-----VEADF LLGLATVP--GYVSFRHVKEGSWYIQSLYNNLKDLVP-RR-----EDIL----------- SILTAVNDDVSRQVD-------IYGKKKQMPQPAFTLRKKLVF---PV---P-------- --------- >G_gallus_ENSGALP00000013506 -----------------------------------------LKSFKPHWISSNMEDDDSL QFRQLLLLIDEGLGAEDVAALKFLCTD--LIPFRKLESVQSAMDIFQLLIDEDYLNE--- ----------EDTFLLAELLYRIKYHSLLSK-LGYTKEKVQECLHE-------------- -----------------------------------------KGKVSPY------------ --------------------------------------------------------RQML YELSENITNDMLQEIVFLLRNHL--------PKRRRTIS----ALELLILLEK------- --------QC-LLTENNVQILEEVFRN-VSPDLLETVKCYRMAKVALPHQGNTLPIKESS PSYTVHVRLFNSPQGGSFILVLN------------------------------------- ------------------ESYCESLRNKKYSVTGASAACHAISMPSTGVQNALANTTV-- ------------------------------------------------------------ -CYSSFLQVSSYK--MDGPRRGICLVINNVKFDGV-------------LQERKGS-YKDA CEL-ERVFTWLGLDVRTYTDQTSDQIKELMQAWQRSED-HKNRDCFVCCILSHGES---- ---G-AVYGKDGKLVSIRTIMTYFTAKQCPQLTEKPKLFFVQ--ACQGKEV-QRPVYVET --DARVPDFSSVPQS---------------------------TSPSESIP-----EEADF LLGMATID--GYASFRHVQEGTWYIQALCSKLQLLVPSRG-----EDIL----------- SILTEVNEDVSKRVD-------RYGTRKQMPQPAYTLRRKLIF---PI---PRDPPPS-- --------- >M_domestica_ENSMODP00000005556 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MEDTGTT--VDAK STKNS------------------------------------------------------- ----------------------------------GVKLFHGSKSVE-------------- ------------------------------------------------------------ ---SGLS-SDSYK--MDYPEMGLCIIINNKNFHPN-----------TGMSFRSGT-DVDA ASL-SDTFRSLKYEVRIKNDLTCNEITELLNSVSKE-D-HSQRSSFICVILSHGEE---- ---G-VIFGTDR-SVELKRLTCFFRGDKCRSLTGKPKLFIIQ--ACRGTEL-DCGVETDS ---------GTD----------------E-------------DIACQKIP-----VEADF LYAYSTAP--GYYSWRNSKDGSWFIQALCAVLKQHAH-K------LEIM----------- QILTRVNRKVATEFESYSLD-ISFHAKKQVPCIMSMLTKELYFSH--------------- --------- >R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MTDDQDCAAELEMADSSTEDG--VDAK PDRSTIISSLLW-KKK-------------------------------------------- ----------------------------------KNASM-----CPVS------------ ------------------------------------------------------------ -TTRDRVPTYLYR--MDFEKMGKCIIINNKNFDKA-----------TGMDVRNGT-DKDA EAL-FKCFRSLGFEVTVYNDCSCAKMQDLLRRASEE-D-HSNSACFACVLLSHGEE---- ---N-LIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRGTEL-DDGIQADS ---------GPIN-D---T---------D-------------ANPRYKIP-----VEADF LFAYSTVP--GYYSWRNPGKGSWFVQALCSILNEHGK-D------LEIM----------- QILTRVNDRVARHFESQSDD-PRFNEKKQIPCMVSMLTKELYFG--R------------- --------- >H_sapiens_ENSP00000286186 ------------------------------------------MKSQGQHWYSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCIG--LVPNKKLEKSSSASDVFEHLLAEDLLSE--- ----------EDPFFLAELLYIIRQKKLLQH-LNCTKEEVERLLPT-------------- -----------------------------------------RQRVSLF------------ --------------------------------------------------------RNLL YELSEGIDSENLKDMIFLLKDSL--------PKTEMT------SLSFLAFLEK------- --------QG-KIDEDNLTCLEDLCKT-VVPKLLRNIEKYKREKAIQIVTPPVD--KEAE S-YQGEEELVSQTDVKTFLEALP------------------------------------- --------------------Q-ESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLN-- ------------------------------------------------------------ -SETSTKRAAVYR--MNRNHRGLCVIVNNHSFTS--------------LKDRQGT-HKDA EIL-SHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPA-HADGDCFVFCILTHGRF---- ---G-AVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQ--ACQGEEI-QPSVSIEA --DALNPEQAP-------------------------------TSLQDSIP-----AEADF LLGLATVP--GYVSFRHVEEGSWYIQSLCNHLKKLVP-RH-----EDIL----------- SILTAVNDDVSRRVD-------KQGTKKQMPQPAFTLRKKLVF---PV---PLDALSL-- --------- >B_taurus_ENSBTAP00000008706 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------S-KKK-------------------------------------------- ----------------------------------KNDSG-----KSVN------------ ------------------------------------------------------------ -IPRDRVPTYQYN--MNFEKVGKCIIINNKNFDRI-----------TGMGVRNGT-DKDA EAL-FKCFRSLGFDVSVYNDCSCAKMQDLLKKASEE-D-HRNSACFACILLSHGEE---- ---N-LIYGTDG-KTAIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRGTEL-DDGIQADS ---------GPIN-D---T---------D-------------ANPRYKIP-----VEADF LFAYSTVP--GYYSWRNPGSGSWFVQALCSILNEHGK-S------LEIL----------- QILTRVNDRVARHFESQSDD-PRFHEKKQIPCVVSMLTKELYF----------------- --------- >T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------TNMSANGPSPGGDF--TDAK KGAGQQP----------------------------------------------------- ----------------------------------RSGSSSGRVTVDA------------- ------------------------------------------------------------ ---KPAAYSFRYS--LDFPNMGHCIIINNKNFDRR-----------TGMNTRNGT-DVDA ANA-MKVFLSLGYKVKVHNDQTVNQMKQLLVSAAEE-D-HSACASFVCVLLSHGDE---- ---G-VFFGTDG-SVELKYLTSLFRGDRCKSLVGKPKLFFIQ--ACRGNDL-DGGIETDS ---------AA-------------------------------DSSTTKIP-----VEADF LYAFSTAP--GYYSWRNTTSGSWFMQSLCDAISKYGK-E------LELQ----------- HILTRVNHKVAVDFESVSNL-PGFDAKKQIPCIVSMLTKEMYFS---------------- --------- >G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MSDTTGDGRGGRVA--SPNK AATD-------------------------------------------------------- ----------------------------------RAACTENLTETDALIR---------- ------------------------------------------------------------ ---SSLDPAEEYK--MDNKRRGLALIFNQERFFWR-----------LGLNDRHGT-NADR YNL-ERRLSNLNFDVRAYDNLKQEEVLNKINEAAEE-N-HSDSDCFLLVFLSHGEN---- ---D-QVYTYDG-KISVQDITSLFKGDKCKSLVGKPKIFILQ--ACRGDKH-DDPVTAC- --DAVDSE---LKTNEVVV---------D-------------ASVLHTLP-----AGADF IMCYSVAE--GYYSHRETINGSWYIQDLCELLQRYGD-S------HEFT----------- EVLTLVNRKVSMRSVGNSSD-RSAIGKKQVPCFASMLTKKLYFR--PK---Q-------- --------- >C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MADDQDCGMEQAAGDSESPDA--VDAR PDRSSFVPSLFS-RKK-------------------------------------------- ----------------------------------KNDSG-----RSIK------------ ------------------------------------------------------------ -TAQDQVPTYQYN--MNFEKVGKCIIINNKNFDKT-----------TGMGVRNGT-DKDA EAL-FKCFRNLGFDVVIYNDCSCAKMQDLLKKASEE-D-HRNSACFACILLSHGEE---- ---N-LIYGTDG-MTAIKDLTAHFRGDRCRTLLEKPKLFFIQ--ACRGTEL-DDGVQADS ---------GPIN-D---T---------D-------------ANPRYKIP-----VEADF LFAYSTVP--GYYSWRSPGSGSWFVQALCSTLNEHGK-S------LEIL----------- HILTRVNNRVARHFESQSDD-PHFHEKKQIPCVVSMLTKELYF----------------- --------- >O_anatinus_ENSOANP00000000517 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AASGEVM--VDSK SFHSSQGY---------------------------------------------------- ----------------------------------SSRKVPGKQFLG-------------- ------------------------------------------------------------ ---SSASLDDRYR--MDYPNMGICLIINNKNFHPD-----------TRMGCRSGT-DVDA ASL-RDTFKKLKYEVRCKNDLKRREILELLTSVAHE-D-HSKRSSFVCVLLSHGEE---- ---G-VIFGTDG-SLELKSLASLFRGDNCRSLVGKPKLFIVQ--ACRGTEL-DSGVEADS ---------SSA----------------D-------------DGSEQKIP-----VEADF LYAYSTAP--GYYSWRNSMNGSWFIQALCAMLKQHAH-T------LELL----------- HILTRVNRKVATEFESYSLD-ATFNAKKQIPCIVSMLTKELYFPY--------------- --------- >X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MASAKQQSSPSAGQIE--KDSS SASQ-------------------------------------------------------- ----------------------------------NKEQKANVAETDGWTS---------- ------------------------------------------------------------ -RTLELDPSAEYK--MTHKRRGLALIFNHEDFYWQ-----------LRLGSRRGT-NTDS MNL-NRILTDLGFDVQNYYNLRTLDILEKIQEASTA-D-HSNADCFLCVFLSHGED---- ---R-HIYSYDS-LIDIQELTNSFKGDKCESLVGKPKIFIFQ--ACRGEKH-DNPVLPT- --DETDSV---TLTNITEV---------D-------------AASLYTLP-----AGADF IMCYSVAE--GYYSHRETVNGSWYIQDLCEVLKAHAA-S------LEFT----------- EILTLVNRKVSQRSVAFCND-PKAIGKKQIPCFSSMLTKKLFLK--PK---SN------- --------- >D_rerio_ENSDARP00000071815 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MSDVKPKGVDT--VDAR QSDAKES----------------------------------------------------- ----------------------------------SSVTDPGLVQMDAK------------ ------------------------------------------------------------ -SHSDDNVDYQYK--TNYPNLGQCLIINNKNFHKR-----------TGMGVRNGT-DEDA KKV-FETFSQLGFKVGHYNDLTVSQMMALLNKASQE-D-HSKSAMFACVLLSHGDD---- ---G-LIYGTDN-SIELKRLFAHFRGDRCTSLVGKPKLFFIQ--ACRGTDL-DSGIECDG ---------VG-------------------------------DEETQRIP-----VEADF LYAYSTAP--GYYAWRNVANGSWFISSLCDMLLKYGK-Q------LEIM----------- QVMTRVNHKVALEFESSSNL-PGFDGKKQIPCIVSMLTKELYFPK--------------- --------- >G_gallus_ENSGALP00000017288 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MMTDIKDGPRSGEDV--SDAR SFPGS------------------------------------------------------- ----------------------------------KGMNLPASKSVD-------------- ------------------------------------------------------------ ---SGILPDDSYR--MDYPEIGVCVIINNKNFHRD-----------TGLSSRSGT-DADA ASV-REVFMKLGYKVKLNNDLSSRDIFKLLKNVSEE-D-HSKRSSFVCVLLSHGDE---- ---G-LFYGTDG-PLELKVLTSLFRGDKCRSLAGKPKLFFIQ--ACRGTEL-DSGIEADS ---------GP-----------------D-------------ETVCQKIP-----VEADF LYAYSTAP--GYYSWRNAAEGSWFIQSLCRMLKEHAR-K------LELM----------- QILTRVNRRVA-EYESCSTR-QDFNAKKQIPCIVSMLTKEFYFPC--------------- --------- >D_rerio_ENSDARP00000050929 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MASHTKSDGSAAVE--KDSA SA---------------------------------------------------------- ----------------------------------GQTVEENLTETDSFNQ---------- ------------------------------------------------------------ -SIFSMDPNQEYD--MNHKRRGMALIFNHENFFWK-----------LGLGYRSGT-NADK ENL-IRRFRELNFEVKAFDDYKRHEVLSKITEAAAA-D-HVDADCFVCVFLSHGEN---- ---G-HVYANDG-QIEIPEITDLFKGDKCRSLVGKPKIFIWQ--ACRGDKH-DDPVTPM- --DVVDSQ----VTNDMVV---------D-------------AGVLYTLP-----AGADF IMCYSVAE--GYYSHRETVNGSWYIQDLCEILRRYGS-E------LEFA----------- EILTLVNRKVSLRSVLNCKD-RSAVGKKQVPCFASMLTKKLFFR--PK---K-------- --------- >D_rerio_ENSDARP00000075318 ------------------------------------------------------------ -------------------------------------------------MADQLLEN--- ----------LRPDLIKGLSERV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------INGLLDDLQQ------- --------KK-VFGEEEIEDIQHRMKT-RADQARHVIDDVKRKGVKASEIMLAS--LKTR DPHLYDTL---------------------------------------------------- -------------------------GIERLLVPVPETELTPSQLSETTGC---------- ------------------------------------------------------------ -STDKTNTMNEYE--MKSNPRGLCLIFNNENFKDP-------------DMKRHGS-QMDT ASL-KDLFEWLGFSVEIKQDQTVSAMKRTLKEYSE--D-RKHGDCFVCCVLSHGNE---- ---S-GVLGSDEKICPVDDITSPFNGANCSSLAGKPKVFFIQ--ACRGHEI-QSKVMVAD ----------GSGGSRTQK---------P-------------GRVSVSIP-----KDSDF LIARSTVE--GYVSIRDRTSGTWFIQSLCENLKEGSK-RG-----HDIL----------- MILTKVNNDVSRKEGSLKVK-NEIVDAKVTPQPIFTLRKLLIFR--PL---KKTGRFS-- --------- >E_caballus_ENSECAP00000019797 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MENSKIS--VDSK SIKNS------------------------------------------------------- ----------------------------------ETKILHGSKSMD-------------- ------------------------------------------------------------ ---SGISLDSSYK--MDYPEMGLCIIINNKNFHKS-----------TGMASRSGT-DVDA ANL-RETFTNLKYEVRNKNDLTGEEIVALMRSVSKE-D-HSKRSSFICVLLSHGEE---- ---G-IIFGTNG-PIDLKKLTCFFKGDCCRSLAGKPKLFIIQ--ACRGTEL-DSGIETDS ---------GIE----------------D-------------DMACQKIP-----VEADF LYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKLYAH-K------LELM----------- HILTRVNRKVAMEFESYCLD-PTFHGKKQIPCIVSMLTKELYFYH--------------- --------- >O_latipes_ENSORLP00000010095 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MASNRPGEDS--TDAR KDNGELAA---------------------------------------------------- ----------------------------------GASPAPDRMDVDG------------- ------------------------------------------------------------ ---KPSSHSFRYS--LNFPTIGLCIIINNKNFDRG-----------TGMNQRNGT-DIDA ASA-MKVFSKLGYRVKIYNDQTVKQIKQLLTDVSRM-D-HSDSASFVCILLSHGDE---- ---G-VFFGTDG-SIELKTLTSLFRGDHCKSLVGKPKLFFIQ--ACRGTEL-DDGIEADS ------------------------------------------KEDTTKIP-----VEADF LYAFSTAP--GYYSWRNTMTGSWFINSLCEMLSKYGK-E------LELL----------- HIMTRVNHMVAVEFESISTL-PGFHAKKQIPCIVSMLTKEMYFY--P------------- --------- >H_sapiens_ENSP00000358327 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQGCIEEQGVEDSANEDS--VDAK PDRSSFVPSLFS-KKK-------------------------------------------- ----------------------------------KNVTM-----RSIK------------ ------------------------------------------------------------ -TTRDRVPTYQYN--MNFEKLGKCIIINNKNFDKV-----------TGMGVRNGT-DKDA EAL-FKCFRSLGFDVIVYNDCSCAKMQDLLKKASEE-D-HTNAACFACILLSHGEE---- ---N-VIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRGTEL-DDGIQADS ---------GPIN-D---T---------D-------------ANPRYKIP-----VEADF LFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHGK-D------LEIM----------- QILTRVNDRVARHFESQSDD-PHFHEKKQIPCVVSMLTKELYFS--Q------------- --------- >P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQGCIEEQGVEDSANEDS--VDAK PDRSSFVPSLFS-KKK-------------------------------------------- ----------------------------------KNVTM-----RSIK------------ ------------------------------------------------------------ -TTRDRVPTYQYN--MNFEKLGKCIIINNKNFDKV-----------TGMGVRNGT-DKDA EAL-FKCFRSLGFDVIVYNDCSCAKMQDLLKKASEE-D-HTNAACFACILLSHGEE---- ---N-VIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRGTEL-DDGIQADS ---------GPIN-D---T---------D-------------ANPRYKIP-----VEADF LFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHGK-D------LEIM----------- QILTRVNDRVARHFESQSDD-PRFHEKKQIPCVVSMLTKELYFS--Q------------- --------- >P_pygmaeus_ENSPPYP00000014602 ------------------------------------------MKSQGQHWCSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCVG--LVPNKKLEKSSSASDVFEHLLAEDLLSE--- ----------EDPFFLAELLYIIRQKKLLQH-LSYTKEEVEGLLPT-------------- -----------------------------------------RQRVSLF------------ --------------------------------------------------------RNLL YELSEGIDSENLKDMIFLLKDSL--------PKTEMT------SLSFPAFLEK------- --------QG-KIDEDNLTCLEDL-KT-VVPKLLRNIEKYKREKAVQIVTPPID--KEAE S-YQGEEELVSQTDVKTFLEALP------------------------------------- --------------------QEESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLN-- ------------------------------------------------------------ -SETGTKGRKGYR--MNRNHRGLC-LLNNHSFTS--------------LKDRRGT-HKDA EIL-SHVFQWLGFTVHIHNNVTKGEMEEVLQEQKCNPA-HADGDCFVFCILTHGKF---- ---G-AVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQ--ACQGEEI-QPSVSIEA --DALNPEQPP-------------------------------TSLQDSIP-----AEADF LLGLATVP--GYVSFRHVEEGSWYIQSLCNHLKKLVP-RH-----EDIL----------- SILTAVNDDVSRRVD-------KQGTKKQMPQPAFTLRKKLVF---PV---PLDALSL-- --------- >B_taurus_ENSBTAP00000016642 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MSSEPPPRRAR----------- ------------------------------------------------------------ ----------------------------------GPGEEQNMTEIDAFPR---------- ------------------------------------------------------------ --REIFDPTEKYK--MDHKRRGIALIFNHERFFWH-----------LTLPNRPGT-SADR DNL-RRRFSDLGFEVKCFDDLRAEELLLKIHEASTA-S-HVDADCFLCVFLSHGEG---- ---N-HIYAYDA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACRGSQH-DVPVIPL- --DVVDHRTDTPDANLTQV---------D-------------AASVYTLP-----AGADF LMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKFGS-S------LEFT----------- ELLTLVNRKVSQRRVDFCRD-PNAIGKKQVPCFASMLTKKLHFS--PK---SK------- --------- >A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------FRR---------- ------------------------------------------------------------ --NHLFDPAAEYK--MSHKRRGLALIFNHEHFFWH-----------LMLPERRGT-QADK ENL-KRGLTDLGFEVKCFDDLKAEEVLQNIYNVSTD-E-HDDADCFLCVFLSHGED---- ---D-HVYAYDA-KIEIKSLTNMFKGDKCPSLVGKPKIFVIQ--ACRGDKH-DDPVIAR- --DTVDSK-KELDINETEV---------D-------------TAAVYTLP-----AGADF LMCYSVAE--GYYSHRETINGSWYIQDLCEMLKRHGS-S------LEFT----------- DLLTLVNRKVSHREVDVCKD-RKALGKKQIPCFASMLTKKLYFR--PK---FK------- --------- >P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MDCVGWPPGRRWHLEKNTSCSGSSGICASYVTQMADDQGCVEEQGLGDSANEDS--VDAK PDRSSFVPFLFS-MKK-------------------------------------------- ----------------------------------KNVSM-----QSIK------------ ------------------------------------------------------------ -TTRDRVPTYQYN--MNFEKLGKCIIINNKNFDKV-----------TGMGVRNGT-DKDA EAL-FKCFRSLGFDVIVYNDCSCAKMQDLLKKASEE-D-HTNAACFACILLSHGEE---- ---N-LIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRGTEL-DDGIQADS ---------GPIN-D---T---------D-------------ANPRYKIP-----VEADF LFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHGK-D------LEIM----------- QILTRVNDRVARHFESQSDD-PRFHEKKQIPCVVSMLTKELYFS--Q------------- --------- >O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MADDQAHAGELGAGDSESADA--VDAK PDRSSFVPALFS-KKK-------------------------------------------- ----------------------------------KNGPK-----QSAK------------ ------------------------------------------------------------ -ATRDQVPSYQYN--MNFDKMGKCIIINNKNFDKV-----------TGMGVRNGT-DKDA EAL-FKCFRSLGFDVMVYNDCSCARMQDLLKRASEE-D-HTNSACFACILLSHGEE---- ---N-LIYGKDG-VIPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRGTEL-DDGIQADS ---------GPIN-D---T---------D-------------ANPRHKIP-----VEADF LFAYSTVP--GYYSWKNPGRGSWFVQALCSILDEHGK-E------LEVM----------- QILTRVNDRVARHFESQSDD-PRFNEKKQIPCVVSMLTKELYFC--R------------- --------- >M_mulatta_ENSMMUP00000037898 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MRIPTKW-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -FYLFFKRAPTYR--MDRNHRGLCVIVNNHSFIS--------------LRDRRGT-HKDA EIL-KGVFQWLGFTVHIYNNVTKGEMEEVLQKEKCNPA-HADGDCFVFCILTHGED---- ---G-AVYSSDEALIPIREIMSHFTALQCPGLAEKPKLFFIQ--ACQGEKI-QLSKSIEA --DALNPEQAP-------------------------------TSLQDSIP-----VEADF LLGLATVP--GYVSFRHVEEGSWYIQSLCNHL---------------------------- ------------------------------------------------------------ --------- >T_rubripes_ENSTRUP00000024164 ------------------------------------------------------------ ---VFLPKDMEAVRRNKTAIGTIFCAD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------YGLILNKVDE------- --------KK-LITRRDYNNLKNINGEDIWGHVIALVDKIMNKGDATCEAFLNL--LQTD DD---------------------------------------------------------- ----------------------------------IKSTYPELKDTHFNI----------- ------------------------------------------------------------ -FFFFYLQDEQYE--LLSQPTGLCVIINNENFL--------------DMKQRSGT-NKDA QSL-AEVFTWLGFRVLMCKDQTKEKMDRALNCFASLVD-PKHGDAFICCILSHGEK---- ---S-AVLGIDGEPLCIKQIIRTFKATRQSALVSKPKMFLIQ--ACQGKGT-HRGVLLKD ----------------LQT---------D-------------DCHTLSIP-----EEADI LVATATVE--DYVSFRHKIDGSWFIQSLCQELKEGCLRG------EDMT----------- TILHRVNSEVSQKEAF-----IHPGEQKQMPEVRFTLRKRLVLS--PHTA---------- --------- >D_rerio_ENSDARP00000075650 ------------------------------------------------------------ ---------------------------------------------MDKKESVDKICE--- ----------NKIFLLETLSVD-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ANFILQHVQQ------- --------AK-LITLRDYNNLSDFPQR--ETKIINLLDKLMGKGEETCHQFIAL--LR-- ------------------------------------------------------------ ----------------------------------QDCVLENFPMLKDHDI---------- ------------------------------------------------------------ -FDSSVQEISPYR--IIKNPRGICVIINNEIFS-------------SGMMSRRGS-DKDR EYL-AKVFHWLGFEVVEHNNKDTAEIRNILKDLGRT----VDGDCFVCCILSHGRR---- ---E-GVCGTDGNYLSIDEIRDPFTGVKCQKLVGKPKLFFIQ--GCRGANSLQACVKVEA --DA--------GNSKAKV---------E-G-----------DNLDITIP-----SDTDF LIARSTTN--GHVSYRHVREGSWFIQSLCRNLEKHCPRG------ADIL----------- TILLYVNNEVSSQKS----------IRKQMPIYEVALTRKLFLR--PV---NP------- --------- >T_guttata_ENSTGUP00000006879 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MTDIGDGAHLGKDL--ADTK SIPGF------------------------------------------------------- ----------------------------------KGKNLPASKSMD-------------- ------------------------------------------------------------ ---SGILPDYSYR--MDYPEMGECIIINNKNFHRY-----------TGMSPRSGT-DADA ASV-REVFMKLGYKIKINNDLSCEGIFNLLKNVSEE-D-HSKRSSFVCVLLSHGDE---- ---G-LIYGTDG-PLELKALTSLFRGDRCRSLAGKPKFFFIQ--ACRGTEL-DSGIETDS ---------GS-----------------E-------------ETMCQKIP-----VEADF LYAYSTAP--GYYSWRNSAEGSWFIQSLCKMLKEHAR-K------LELM----------- QILTRVNRRVA-EYESCSTR-QDFNAKKQIPCIVSMLTKEFYFPS--------------- --------- >E_caballus_ENSECAP00000003321 ------------------------------------------------------------ ---------------MAAPSAPSLPALQQKGLMAADRGRRILGVCGMHPDHQEALKK--- ----------NRVVLAKQLL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSELLEHLLE------- --------KD-IITLEMRELIQAKVTS--FGQNVELLNLLPKRGPQAFEAFCVA--LRET KQGHLEDLLLTTLSG--LQ------------------------------HVLPPLSCDYD LSLPFPVCESC-----------------PPHKQLRLST-DTVEHSLDNGDGPPCLQVK-- ---------------------------------------------------------PCT PEFYQAHYQLAYR--LQSRPRGLALVLSNVHFTGE-----------KDLEFRSGG-DVDH STL-VTLFKLLGYNVHVLLDQTAKEMQEKLQNFAQLPA-HRVTDSCIVALLSHGVE---- ---G-GIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ--ACRGDET-DRGVDQQ- --DGKNHAKSPECEESDA----------GKE-----------ELLKMRLP-----TRSDM ICGYACLK--GTAAMRNTKRGSWYIEALTQVFSERAC-D------MHVA----------- DMLVKVNALIKEREGYAPG--TEFHRCKEMSEYCSTLCRHLYLF--PG---HPPT----- --------- >C_elegans_C48D1.2 ------------------------------------------------------------ ---------------------------------------------MMRQDRRSLLER--- ----------NIMMFSSHLK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VDEILEVLIA------- --------KQ-VLNSDNGDMINSCGTV--REKRREIVKAVQRRGDVAFDAFYDA--LRST GHEGLAEVLEPLARSVDSNAVEF--------------------ECPMSPASHRRSRALSP AGYTSPTRVHRDSVSSVSSFTSYQDIYSRARSRSRSRALHSSDRHNYSSPPVNAFPSQ-- --------------PSSANSSFTGCSSLGYSSSRNRSFSKASGPTQYIFHEEDMNFVDAP TISRVFDEKTMYR--NFSSPRGMCLIINNEHFE--------------QMPTRNGT-KADK DNL-TNLFRCMGYTVICKDNLTGRGMLLTIRDFAKH---ESHGDSAILVILSHGEE---- ---N-VIIGVDDIPISTHEIYDLLNAANAPRLANKPKIVFVQ--ACRGERR-DNGFPVLD SVDGVPAFLRRGWDNRDGPLFNFLGCVRPQV-----------QQVWRKKP-----SQADI LIAYATTA--QYVSWRNSARGSWFIQAVCEVFSTHAK-D------MDVV----------- ELLTEVNKKVACGFQTS----QGSNILKQMPEMTSRLLKKFYFW--PEARNSAV------ --------- >G_gallus_ENSGALP00000013591 -----------------------------------------------------------M EFSQLLFVISEALDRTELASLKFLSLE--HVTVRKREDIEEPKAFFQALQEKGMIEV--- ----------GDLFFLKELLYRINRIDLLASYLGSSREEMERELQVPG------------ -----------------------------------------RARVSPF------------ --------------------------------------------------------RYLL FQLSENITKDDMKCFKFLLGKEL--------PKCKLSPETT--MPDVFIEMEK------- --------KG-ILKEDNLTVLKTICGK-VDKSLLKKIEDYELNLLG-----EGE--MLVT EGQRSSTGAPED------------------------------------------------ ----------------------------------SAIWLASSVAPDSLG----------- ------------------------------------------------------------ -NCDQSSQLEVYK--MTSRPRGVCLILNNHNFAKA----REAVPELRRMKDRNGT-HVDA DAL-RKVFSNLHFTVAEYKDCTAEEIRNIVNNYRCM-D-HNNKDCFVCCILSHGKK---- ---G-IIYGVDGQEVPIQELTTSFTGQNCQSLAGKPKVFFVQ--ACQGDAY-QKGVTIET --DS------GEQDYSLET---------D-A-----------RFQLDCIP-----SEADF LLGMATLQ--DYVSYRSPSQGTWYIQSLCQHLESSCP-RG-----EDIL----------- TILTAVNQEVSSKID-------KQNAGKQMPQPSFTLRKKLIF---PV---N-------- --------- >T_nigroviridis_ENSTNIP00000010722 ------------------------------------------------------------ MDLQLLSRICEQLDSQEVASLCFLCRE--AVSKKSLEGINDARGLFKKLADQCLL----- ----------ENNSFLRQLLQTIRREDLLRLLGADNRQLMETDA---------------- -----------------------------------------SPLLSGY------------ --------------------------------------------------------SVML YNIYEDLCKEDLGKIKFFLGDKL--------GRRPTEMCKT--VLDVFAEMEK------- --------KG-FLSEIYLDELHSVLQN-VNPLLASKVQQHMQHLRDNHRPVAAL--PSDP AQV--------------------------------------------------------- ----------------------------------RLPVRETQL---RDVEQNLFSDAE-- ---------------------------------------------------------PAV RPSRTANDTEYYS--LTHKPHGLCVVFNNEFFPRT------------GLRERAGTIEDDA DSL-RAVFTKLGFTVVVHKDLTATDIERELQRLANR-N-FVNEDALVVCVLSHGQK---- ---G-CFYGTDGATVKIQDVTQPFTSTRVPTLAGKPKLFFIQ--ACQGDDL-QMGCVPCP ---PRPAQNVDMEQSRLEE---------DAG-----------FVRGETVP-----DGADF LLGMATVQ--DYKAFRNTTTGSIYIQELCSPVTKSAESSEQ----DDIL----------- SILTRVNREVSKGVF--------QWRKKQMPEPKYTLTKKLVLK--LD------------ --------- >X_tropicalis_ENSXETP00000015203 ------------------------------------------------------------ ------------------------------------------MLGGMQKHHKDALQR--- ----------LRVTLLHDMI---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------IEELVEHLVS------- --------SG-ILTPIMHSTIMAHRSE--YKQNVTLLTQLPKRGPRAFSEFCNA--LHAT GQRHLAEQLEEEAQQQQME---------------------------------SVTPEVHE RSFPLPVQEST-----------------PSRPRRQFCR-EYNEESIDDGDGPGTVQ---- ---------------------------------------------------------LCS VDFYLSHHQQAYK--MHSCPRGRALIISNVAFETQ------------DLDHRYGG-EVDV TSL-EKLFSSLGFQVEVRRNLNAQNMMSQLGAFSALPA-HSALDSCVVAVLSHGLD---- ---G-AVYGTDGKLVQLQDVFTAMDNAHCPQLQNKPKMFFIQ--ACRGEEA-DRGVDQR- --DGREQSASPGCEQSDA----------GR------------EDIKVRLP-----TQSDM ICAYACLK--GTVSLRNTKRGSWFVQDLVSVFSQYSK-N------THVA----------- DMLVKVNALIKEREGHAPG--TEFHRCKEMSEYCSTLCRDLYLF--PG------------ --------- >O_anatinus_ENSOANP00000005811 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PRGATRLARGHP----------- ------------------------------------------------------------ ----------------------------------AAGGAPNVTEVDGFYD---------- ------------------------------------------------------------ --RETFDPAAKYK--MEYKRRGVALIFNHERFYWQ-----------LKLPDRHGT-RADR ENL-IRRLSALGFEVKCFDDLKAEEVMLKIHQASSS-N-HADADCFLCVFLSHGQG---- ---N-HVYAYNG-KIDIPEMTSMFKGDQCRSLVGKPKIFIFQ--ACRGEQH-DVGVVPL- --DVVDSKISEQDVNETEV---------D-------------AASVYTLP-----AGADF LMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGRYGS-S------LEFT----------- ELLTLVNRKVSYRRVDFCKD-PSLIGKKQVPCFASMLTKKLHFL--PK---AQ------- --------- >X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------STKK-------------------------------------------- ----------------------------------KKTEDPEKPPQASD------------ ------------------------------------------------------------ -NVRIVTPAFQYK--MNYGKVGRCIIINNKNFDDI-----------TGMSPRNGT-DIDA RDL-LRCFKGLGFDVTVFNNKSCTEMETLLRSVAEQ-D-HKDSACFACIFLSHGEE---- ---G-LIYGTDG-AMPIKVLTTLFRGDKCRSLVGKPKLFFIQ--ACRGCEF-DDGLETDA ---------GPSN-DSLET---------D-------------ANPRHKIP-----VEADF LYAYSTVP--GYYSWRNPGRGSWFVQALCNVLNEHGK-E------LEVM----------- QILTRVNYLVATQFESYCDD-PQFNKKKQIPCVVSMLTKELYFK--PC------------ --------- >G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MADDQGCVXXXXXXXXXXXXX--XXXX XXXXXXXXXXXX-XXX-------------------------------------------- ----------------------------------XXXXX-----XXXX------------ ------------------------------------------------------------ -XXXXXXXXXXXX--XXXXXXXXXXXXXXXXFDKV-----------TGMGVRNGT-DKDA EAL-FKCFRSLGFDVIVYNDCSCAKMQDLLKKASEE-D-HTNAACFACILLSHGEE---- ---N-VIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRGTEL-DDGIQADS ---------GPIN-D---T---------D-------------ANPRYKIP-----VEADF LFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHGK-D------LEIM----------- QILTRVNDRVARHFESQSDD-PRFHEKKQIPCVVSMLTKELYFS--Q------------- --------- >E_caballus_ENSECAP00000013731 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MADDQDCVVEQGAGDSTSTDA--VDAK PDRSSFVPSLFS-KKK-------------------------------------------- ----------------------------------KNGPE-----RSIT------------ ------------------------------------------------------------ -TNRNREPTYQYN--MNFEKVGKCVIINNKNFDRG-----------TGMGVRNGT-DKDA EAL-FKCFRNLGFDVVVYNDCSCAKMKSLLKQASEE-D-HRNSACFACILLSHGEE---- ---N-LIYGTDG-MTPIKDLTGHFRGDRCKTLLEKPKLFFIQ--ACRGTEL-DDGIQADS ---------GPINDD---T---------D-------------ANPRYKVP-----VEADF LFAYSTVP--GYYSWRNPGSGSWFVQALCSILNEHGK-S------LEII----------- QILTRVNHRVARHFESHSDD-PRFHQKKQIPCVVSMLTKELYF----------------- --------- >M_musculus_ENSMUSP00000031895 ------------------------------------------------------------ ---------------MAAPSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKK--- ----------NRVVLAKQLL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSELLEHLLE------- --------KD-IITLEMRELIQAKGGS--FSQNVELLNLLPKRGPQAFDAFCEA--LRET RQGHLEDLLLTTLSD--IQ------------------------------HVLPPLSCDYD TSLPFSVCESC-----------------PPHKQLRLST-DATEHSLDNGDGPPCLLVK-- ---------------------------------------------------------PCT PEFYQAHYQLAYR--LQSQPRGLALVLSNVHFTGE-----------KDLEFRSGG-DVDH TTL-VTLFKLLGYNVHVLHDQTAQEMQEKLQNFAQLPA-HRVTDSCVVALLSHGVE---- ---G-GIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ--ACRGDET-DRGVDQQ- --DGKNHTQSPGCEESDA----------GKE-----------ELMKMRLP-----TRSDM ICGYACLK--GNAAMRNTKRGSWYIEALTQVFSERAC-D------MHVA----------- DMLVKVNALIKEREGYAPG--TEFHRCKEMSEYCSTLCQQLYLF--PG---YPPT----- --------- >T_guttata_ENSTGUP00000004278 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MSGSERRPPAGHVQ--LDSR PTLP-------------------------------------------------------- ----------------------------------TTDGNENITEVDALNI---------- ------------------------------------------------------------ --RQSLDPAEEYK--MNHQRRGLALIFNHERFYWH-----------LRLQDRRGT-WVDR NNL-KSILTELGFEVRLFDDLKKEDVQQRIYEASTA-D-HSNADCFVCVFLSHGED---- ---G-HIFAYDD-KIEIQTITDMFRGDKCQSLVGKPKIFIIQ--ACRGDKH-DDAVIAH- --DSADG--SESPGNETDV---------D-------------AAGVYTLP-----AGADF IMCYSVAQ--GYYSHRDTINGSWYIQDLCETLRKHGS-S------LEFA----------- ELLTVVNRKVSCRRVGMCKD-INAIGKKQIPCFASMLTKKLYFH--PK---SK------- --------- >M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------S-KKK-------------------------------------------- ----------------------------------KNVSG-----QSIK------------ ------------------------------------------------------------ -TTRDRVPTYQYN--MNFEKMGKCIIINNKNFDKV-----------TGMGVRNGT-DKDA EAL-FKCFQSLGFDVIVHNDCSCAKMKDLLKKASEE-D-HTNAACFACILLSHGEE---- ---N-LIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRGTEL-DDGIQADS ---------GPIN-D---T---------D-------------ANPRYKIP-----VEADF LFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHGK-D------LEIM----------- QILTRVNDRVARHFESQSDD-PCFHEKKQIPCVVSMLTKELYFS--H------------- --------- >C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------MSLKSAADVLMSGVPTPHTNENNNVGQSE--VDAL GSG--------------------------------------------------------- ----------------------------------ETPRIYSLPDV--------------- ------------------------------------------------------------ -TKMASSEVECYQ--MDRESRGLALIINNENFHHA-----------TRMNKRSGT-DVDA RNL-SRIFKKLGFDVQVYKDLSCISMLEVINEVSTM-D-HTGNDCCFVAFLSHGDD---- ---G-CVYGTDG-IVQIKKIVDQFRGDVCPSLAGKPKIFLFQ--ACRGTLH-ETSVQLSV --DVVDG----EDQPCVEV---------D-------------AAPVPTLP-----SGSDY LFCYSVAE--GYYSHRDTLYGSWFIQDFTDVMEQLVLNKGKQQDKVDFI----------- DVLTVVNRKVSARRVERSYS-QQALGKKQMPCYLSMLTKKLYLT--PKK----------- --------- >M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MENTENS--VDSK SIKSL------------------------------------------------------- ----------------------------------EPKIIHGSKSVD-------------- ------------------------------------------------------------ ---SGISLENSYK--MDYPEMGLCIIINNKNFHKS-----------TGMASRSGT-DVDA ANL-RETFINLKYEVRNKNDLTREEIVELMRNVSKE-D-HSKRSSFVCVLLSHGEE---- ---G-IIFGTNG-PLDLKKITSFFRGDCCRSLTGKPKLFIIQ--ACRGTEL-DCGIETDS ---------GVE----------------D-------------DMACHKIP-----VEADF LYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYAD-K------LEFM----------- HILTRVNRKVATEFESFSLD-ATFHAKKQIPCIVSMLTKELYFYH--------------- --------- >G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MSVNGPGEDR--TDAK TEQSE------------------------------------------------------- ----------------------------------VSSSASAPEEVDA------------- ------------------------------------------------------------ ---KPNVHSFRYS--LSFPSIGQCIIINNKNFDRG-----------TGMNQRNGT-DVDA ANA-MKVFGNLGYKVKVYNDQSVAQIQHVLTSVSKQ-D-HSCSASFVCVLLSHGDG---- ---D-LFFGTDG-PVPLKSLTSLYRGDRCKSLVGKPKLFFIQ--ACRGTEL-DPGIEADS ---------V--------------------------------KDETTRIP-----VEADF LYAFSTAP--GYYSWRNTTTGSWFMQSLCDMISKYGK-E------LELQ----------- HIMVRVNHKVAVAFESVSNS-PDFNARKQIPCVVSMLTKEMYFS--P------------- --------- >R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MTETDGFYR---------- ------------------------------------------------------------ -SREVLDPAEQYK--MDHKRRGTALIFNHERFFWH-----------LALPERRGT-NADR DNL-TRRFSELGFEVKCFNDLRAEELLLKIHEVSTS-S-HVDADCFLCVFLSHGEG---- ---N-HIYAYDA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACRGSQH-DVPVVPL- --DVVDHQTDKLDDNVTQV---------D-------------AASVYTLP-----AGADF LMCYSVAE--GYYSHRETVNGSWYIQDLCEMLARHGS-S------LEFT----------- ELLTLVNRKVSQRRVDFCKD-PGAIGKKQVPCFASMLTKKLHFC--PK---PSK------ --------- >T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GSDA--ELGK TATD-------------------------------------------------------- ----------------------------------SSACTGDLMETDAISG---------- ------------------------------------------------------------ -SIGFLDPAEEYK--MDNKRRGLALIFNQERFFWR-----------LGLRDRHGT-NADS YNL-QRRLKELNFEVKVFDNHTQAQVLEIITSAAKD-D-HSNVDCFLVVFLSHGEN---- ---D-HIYTFDD-KINVQDITSLFKGDKCKSLVGKPKIFILQ--ACRGDKH-DEPATAAA -FDDVDSE---LKKNEVEV---------D-------------ASAVYTLP-----AGADF IMCYSVAE--GYYSHRETVNGSWYIQDLCDLLRKYGD-S------LEFT----------- ELLTLVNRKVSMRSVGYCSD-PNAIGKKQVPCFASMLTKKLYFR--PK---K-------- --------- >T_nigroviridis_ENSTNIP00000001216 ------------------------------------------------------------ ----------------------------------------SAYQLFLSLCDQDHLSE--- ----------ERPHLLSELLSIIQRTRLLRDLDLRSSAT--------------------- -----------------------------------------SNLISAY------------ --------------------------------------------------------RKLL YSLSEDLTDDNLKEIKFLLTETL--------PRRKLEDNVT--TLEVFLELEC------- --------MD-LLSKTNLGLLKSILQP-VCPVLAERIRQFEAQNSCQPAADWGF--AVKK ITDPLQVQ---------------------------------------------------- ---------------------GGSDALPSLPEENQSSSRTEASVMSSANAVGIKPGTL-- --------------------------------------------------MLGLSPPPVG SPNFPVQDLGTYP--MTTLPRGCCLIISNYDFQGS------------GLGMRNGT-RTDE ECL-KKVFEWLGFKVEIHRDCTGKEILSLMQELADK-S-QQRWDCLVCCILSHGLE---- ---G-CVHGVDGDQVSIKKLIEPFLGTNCPAMAGKPKLFFIQ--ACQGKKQ-QGVVHLES --DG-------AEHSDVDT---------D-A-----------VRLSNCIP-----SHADF LLGMATVP--DYVSYRDRERGTWYIQSLCEYLVKMVP-RG-----FDLM----------- SILTKVNEDVSKKND-------NTGDRKQMPQPVFTITKRIVF---PV---PSGPAPVLP HFPFVEDSP >G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MDKLYRDV------------- ------------------------------------------------------------ ---QSGEDKYRYK--MDYPCMGTCVIINIKNFDLK-----------TGLETRNGT-DVDA AEL-EKTFSKLGYKVTLVHDQTADQIVDLLRDVSTQ-D-HSNSGSFVCVLLSRGDE---- ---G-GIYGTDGSFVNLDELTKFVDGNGCRSLVGKPKLLFIQ--AARGNKL-DDGTLSEG ---------DSM----------------D-------------GQTPSRIP-----VEADF LYAYSTTP--GFNAWRDTQNGSWFMQSLCEMLRRFSG-Q------LELM----------- QIMTRVNNKVALEYKTT----PGRSGKRQMPCIVSLLTKEFYFP---------------- --------- >M_musculus_ENSMUSP00000029626 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MTETDGFYK---------- ------------------------------------------------------------ -SREVFDPAEQYK--MDHKRRGVALIFNHERFFWH-----------LTLPERRGT-NADR DNL-TRRFSDLGFEVKCFNDLRAEELLLKIHEVSTS-S-HIDADCFICVFLSHGEG---- ---N-HVYAYDA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACRGSQH-DVPVVPL- --DMVDHQTDKLD-NVTQV---------D-------------AASVYTLP-----AGADF LMCYSVAE--GYYSHRETVNGSWYIQDLCEMLARYGS-S------LEFT----------- ELLTLVNRKVSQRRVDFCKD-PDAIGKKQVPCFASMLTKKLHFC--PK---PSK------ --------- >T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MAGEAAGIPELGGEAEGEHRCEDD--VDAK PDRRGRFLLFKS-KKK-------------------------------------------- ----------------------------------NDGQMREQDYCSES------------ ------------------------------------------------------------ -HYRIVSPTFQYR--MSHQRVGKCIIINNKNFDEK-----------TGMNVRNGT-DRDA GEL-YKCFKSLGFDVFIYNDQTCEKMEHLLREASEE-D-HSDSSCFACILLSHGEE---- ---G-MIYGTDG-AMPIKTMTSMFRGDMCKSLVGKPKLFFIQ--ACRGSEF-DDGIQTDS ---------GPPN-DTMET---------D-------------ANPRHKIP-----VEADF LFAYSTVP--GYYSWRNPGRGSWFVQALCNVLNEFGK-Q------LEIM----------- QILTRVNYMVATSFESWSED-PRFSEKKQIPCVVSMLTKELYFK--PC------------ --------- >R_norvegicus_ENSRNOP00000022672 ------------------------------------------------------------ ---------------MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKK--- ----------NRVVLAKQLL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSELLEHLLE------- --------KD-IITLEMRELIQAKGGS--FSQNVELLNLLPKRGPQAFDAFCEA--LRET RQGHLEDLLLTTLSD--IQ------------------------------HILPPLSCDYD SSLPFSVCESC-----------------PPHKQSRLST-DTMEHSLDNGDGPPCLQVK-- ---------------------------------------------------------PCT PEFYQAHYQLAYR--LQSQPRGLALVMSNVHFTGE-----------KDLEFRSGG-DVDH TTL-VTLFKLLGYNVHVLYDQTAQEMQEKLQNFAQLPA-HRVTDSCIVALLSHGVE---- ---G-GIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ--ACRGDET-DRGVDQQ- --DGKNHAQSPGCEESDA----------GKE-----------ELMKMRLP-----TRSDM ICGYACLK--GNAAMRNTKRGSWYIEALTQVFSERAC-D------MHVA----------- DMLVKVNALIKEREGYAPG--TEFHRCKEMSEYCSTLCQQLYLF--PG---YPPT----- --------- >M_musculus_ENSMUSP00000091238 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MENNKTS--VDSK SINNF------------------------------------------------------- ----------------------------------EVKTIHGSKSVD-------------- ------------------------------------------------------------ ---SGIYLDSSYK--MDYPEMGICIIINNKNFHKS-----------TGMSSRSGT-DVDA ANL-RETFMGLKYQVRNKNDLTREDILELMDSVSKE-D-HSKRSSFVCVILSHGDE---- ---G-VIYGTNG-PVELKKLTSFFRGDYCRSLTGKPKLFIIQ--ACRGTEL-DCGIETDS ---------GTD----------------E-------------EMACQKIP-----VEADF LYAYSTAP--GYYSWRNSKDGSWFIQSLCSMLKLYAH-K------LEFM----------- HILTRVNRKVATEFESFSLD-STFHAKKQIPCIVSMLTKELYFYH--------------- --------- >C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SSATCGLRRAY----------- ------------------------------------------------------------ ----------------------------------RTADEQNVTETDAFYK---------- ------------------------------------------------------------ --REMFDPEEKYK--MDHKRRGIALIFNHERFFWH-----------LTLPDRRGT-SADR DNL-VRRFSELGFEVKCFNDLKAEELLLKIHEASTS-S-HIDADCFLCVFLSHGEG---- ---N-HIYAYDA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACRGDQH-DVPVLPL- --DVVDHRTDKLEDNVTEV---------D-------------AASVYTLP-----AGADF LMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKFGS-S------LEFT----------- ELLTLVNRKVSQRRVDFCKD-PNAIGKKQVPCFASMLTKKLHFF--PK---SK------- --------- >B_taurus_ENSBTAP00000024166 ------------------------------------------------------------ ---------------MAAPSAGFQYPLQPKEQMAADRGRRMLRGCGMHPDHQEALKK--- ----------NRVVLAKELL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSELLEHLLE------- --------KD-IITLEMREHIQAKTGS--FGQNVELLNLLPKRGPQAFDAFCVA--LRET KQSHLEELLLRTLSG--LQ------------------------------PVVPPLSCDYD LSLPFPVCESC-----------------TRHKRLHLSP-DAVEHSLDHGDGPPCLQVK-- ---------------------------------------------------------PCT PEFYQTHHHLAYR--LQSRPRGLALVLSNVHFTGE-----------KDLEFRSGG-DVDH STL-VTLFKLLGYKVHVLLDQTAQEMQEKLQNFAQLPV-HRVTDSCIVALLSHGVE---- ---G-GVYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ--ACRGDET-DRGVDLQ- --DGKNHDRSPKCEESDA----------SRE-----------ELLKMRLP-----TRSDM ICGYACLR--GTAAMRNTKRGSWYVEALTQVFSERAC-D------MHVA----------- DMLVKVNALIKEREGYAPG--TEFHRCKEMSEYCSTLCRHLYLF--PG---HPPT----- --------- >P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MENTENS--VDSK SIKNL------------------------------------------------------- ----------------------------------EPKIIHGSQSMD-------------- ------------------------------------------------------------ ---SGISLDNSYK--MDYPEMGLCIIINNKNFHKS-----------TGMTSRSGT-DVDA ANL-RETFRNLKYEVRNKNDLTREEIVELMRDVSKE-D-HSKRSSFVCVLLSHGEE---- ---G-IIFGTNG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQ--ACRGTEL-DCGIETDS ---------GVD----------------D-------------DMACHKIP-----VEADF LYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYAD-K------LEFM----------- HILTRVNRKVATEFESFSFD-ATFHAKKQIPCIVSMLTKELYFYH--------------- --------- >H_sapiens_ENSP00000311032 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MENTENS--VDSK SIKNL------------------------------------------------------- ----------------------------------EPKIIHGSESMD-------------- ------------------------------------------------------------ ---SGISLDNSYK--MDYPEMGLCIIINNKNFHKS-----------TGMTSRSGT-DVDA ANL-RETFRNLKYEVRNKNDLTREEIVELMRDVSKE-D-HSKRSSFVCVLLSHGEE---- ---G-IIFGTNG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQ--ACRGTEL-DCGIETDS ---------GVD----------------D-------------DMACHKIP-----VEADF LYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYAD-K------LEFM----------- HILTRVNRKVATEFESFSFD-ATFHAKKQIPCIVSMLTKELYFYH--------------- --------- >P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MENTENS--VDSK SIKNL------------------------------------------------------- ----------------------------------EPKVIHGSKSMD-------------- ------------------------------------------------------------ ---SGISLDNSYK--MDYPEMGLCIIINNKNFHKS-----------TGMASRSGT-DVDA ANL-RETFRNLKYEVRNKNDLTREEIVELMRDVAKE-D-HSKRSSFVCVLLSHGEE---- ---G-IIFGTNG-PVDLRKITNFFRGDRCRSLTGKPKLFIIQ--ACRGTEL-DCGIETDS ---------GVD----------------D-------------DMACHKIP-----VEADF LYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYAD-K------LEFM----------- HILTRVNRKVATEFESFSLD-ATFHAKKQIPCIVSMLTKELYFYH--------------- --------- >B_taurus_ENSBTAP00000038128 -----------------------------------------------------------M ALTQCLYNIGEQLGSDDLAALKFLSRD--HIPYRKQEPIKDALMLFQRLQEKRMLEE--- ----------NNLSFLKELLFRVNRLDLLLNYLYTSEEEMKRELQIPG------------ -----------------------------------------RAQISAY------------ --------------------------------------------------------RILL FQISEDVNKVELKDFKFFLSQEI--------AKCKLDDDMT--LLDIFVEMEK------- --------RT-ILGEENLDTLKRICEQ-VNKSLLKKIYDYEELRKERRMSLERD--PYAF SNDMSQSLPEE------------------------------------------------- ----------------------------------GYSKMPAMSDSP-EQ----------- ------------------------------------------------------------ -DSELQTSDTVYR--MTSKPRGYCLIFNNYDFSIA----RKQVPELHDLKDRTGT-DFDA DAL-DKTFRELHFEIVHYKDLTAKGICEVLESYQKK-D-HKNKDCFICCILTHGNK---- ---G-IIYGSDGQEASIYELTSYFTGLKCPSLIGKPKIFFIQ--ACQGDKY-QKGVAVET --DS------EQMEAYLEV---------D-S-----------SPQKRYIP-----DEADF LLGMATVK--NYVSYRNIWNGAWYIQSLCQNLRERCP-RG-----EDIL----------- TILTKVNFEVSKLDD-------KQRMAKQMPQPTFTLRKKLFF---PL---N-------- --------- >M_musculus_ENSMUSP00000026062 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MTDDQDCAAELEKVDSSSEDG--VDAK PDRSSIISSILL-KKK-------------------------------------------- ----------------------------------RNASA-----GPVR------------ ------------------------------------------------------------ -TGRDRVPTYLYR--MDFQKMGKCIIINNKNFDKA-----------TGMDVRNGT-DKDA GAL-FKCFQNLGFEVTVHNDCSCAKMQDLLRKASEE-D-HSNSACFACVLLSHGEE---- ---D-LIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACRGTEL-DDGIQADS ---------GPIN-D---I---------D-------------ANPRNKIP-----VEADF LFAYSTVP--GYYSWRNPGKGSWFVQALCSILNEHGK-D------LEIM----------- QILTRVNDRVARHFESQSDD-PRFNEKKQIPCMVSMLTKELYFS--R------------- --------- >M_domestica_ENSMODP00000036247 -----------------------------------------------------------M DFHTFLYGIAEEIDSADLASLKFLCLD--QIPLKKQQHIKDALVLFQTLEERGLLEE--- ----------DNLFFLKELLFRINRIDLLNEPLNTKGPEMERELQVPN------------ -----------------------------------------KARISPY------------ --------------------RLHLHTTIWPFRDNWTCRITLSVSFTSRTKQLLSVMVILL FNLSEGVGPSELKSIKFMLSSKI--------PKCKIEDDMT--LMDLFIEMEK------- --------RG-ILGEGNLDALKIVCDQ-IDKSLLKKIQEYEISKGR-------------- ------------------------------------------------------------ ----------------------------------NNLFLIYQNTQPQEV----------- ------------------------------------------------------------ -YDSAGEKGNVYK--MSSRPRGYCLIINNFDFKIS----RKERPENHYLTDRRGT-NKDE EAL-KNIFKELHFDIQSFQDLTAEGIQQVLKTFKDN-N-HESKDCFVCCLLSHGNK---- ---G-TIYGIDGKEVPIRDLTSYFSGSNCPSLAGKPKVFFIQ--ACQGKAT-QYGISLDT --DS------EQQRESLEA---------D-K-----------SFQSECIP-----NEADF LLGMATVE--NYVSYRDSARGTWYIQSLCKNLKEGCL-RG-----NDIL----------- TILTEVNSEVSQKTD-------PKNNGKQMPQPKITLRKKLVF---PI---S-------- --------- >G_aculeatus_ENSGACP00000016983 ------------------------------------------------------------ ------MSARGKVRSQKTAIHEALCAD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------YSLILNKVFE------- --------KG-LITPREYRNLKSINKESVEGHVIELVDKLLDKGEDTCEAFLSL--LQTD DD---------------------------------------------------------- ----------------------------------IVKTYPALRTLQLDDRGTLHAPVQ-- -------------------------------------------------DTSVGHSDVRP PPSKKLKKDERYE--LNSQPSGLCVIINNKNFS----------------KPRRGS-DKDA ESL-GEVFTWLGFRALMCKDQTKDQMERALNKFTALQEAPRHGDALICCILSHGRK---- ---G-VVLGIDDQPLSIKQIIGTFLPPANTTLTGKPKVFLIQ--ACQGGQA-QHGVFEE- ----------------LQA---------D-------------DSPSPTIP-----KEADV LVAVATVE--DYLAFRHITDGSWFIQSVCEQLKDGCPRG------EDIT----------- TILQRVNWEVGKKEGC-----SAPGAGKQMPEVRFTLRKKLVLS--PHPNCFVAK----- --------- >T_guttata_ENSTGUP00000013612 ------------------------------------------------------------ ----------------------------------------MLAACGMQRCHQEALKK--- ----------NRVMLAKQLV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LNVLVEHMVE------- --------KD-IIPTEMVEMIQAKSGS--FDRNVEFLNLLPKRGPNAFSAFCEA--LRET QQQHLETLILKTMSS--LS------------------------------QEIARLEHCHE SDLPYPASESC--------------NSKRPRWL------EPMEHSLDNRDGPSIPPVK-- ---------------------------------------------------------YCT PEFYHNHQHLAYK--LTSEPRGLALILSNVRFSSE-----------KDLEYRAGG-DVDC ASL-EMLFRHLGYRVTVFCDQTAQDMQNALERFSKLQD-HRDVDSCIIALLSHGVE---- ---G-GVYGSDGKLLELQETFRLFDNANCPNLQNKPKMFFIQ--ACRGDEL-DRGVDQR- --DGKGRSDSPGCEESDA----------NKE-----------ESLKLRLP-----TCSDM ICGYACLK--GTAAMRNTKRGSWYVEALTSVFAEDSQ-H------THVA----------- DMLVKVNRQIKQREGYAPG--TEYHRCKEMSEYCSTLCRDLYLF--PG---YLPGK---- --------- >M_domestica_ENSMODP00000007353 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KSFGLFFVF----------- ------------------------------------------------------------ ----------------------------------EGDAEQNATEIDAFFK---------- ------------------------------------------------------------ --SKPLDPAEQYK--MDHKRRGVALIFNHERFFWH-----------LTLPERRGT-RADR DNL-RQRLSDLGFEVNCFDDLKAEDLLMTIHMVSTS-S-HIDADCFLCVFLTHGEG---- ---N-HIYAYDA-KIDIQKLTAMFKGDKCQTLVGKPKIFVIQ--ACRGDQH-DIPVIPL- --DVVDHLSDKVDVNETEV---------D-------------AASVYTLP-----AGADF LMCYSVAE--GYYSHRETVHGSWYIQDLCEMLEKYGS-S------LEFT----------- ELLTLVNRKVSQRRVDFCKD-PNAIGKKQVPCFASMLTKKLYLF--PK---PK------- --------- >G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MSPRNGT-DVDA ADA-FRTFSKLGYKVTVANDQTVDQMIQLLVKVSKQ-D-HSNSASFVCVLLSHGDE---- ---G-VIYGTDG-FEKLDDLTKFFKGDRCRSLVGKPKLFFIQ--ACRGTEL-DEGSQIEA ---------DSV----------------G-------------GQTSDRIP-----VEADF LYAYSTAP--GYYAWRNTQNGSWFMQSLCEMLRRFSG-Q------LELM----------- QIMTRLNHRVALHFESSSDT-PGYSGKKQIPCIVSMLTKDFYFPK--------------- --------- >D_rerio_ENSDARP00000024255 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------EQYE--MKGERRGVCLIINNYDFSAC------------GWLNREGT-DIDH DSL-RDVFEWLGFEILTRRDCTGDQILQALMDLSTQ-D-HTQADCVVCCILSHGRL---- ---N-DIIGVDGKAVPFKELMETLSPFRCSSLYQKPKLFFIQ--ACRGTQN-QRAVFPQT --FT-------EDEDVLAS---------D-A-----------GVPRDSIP-----EMADY LMAMSTVP--WYASYRDKSKGTWFIQSLCDNLRLLVP-RG-----NDLL----------- SILTKVNADVSKKSD-------KSGLKKQMPQPEFSLTRTVVF---PP---PGLP----- --------- >C_familiaris_ENSCAFP00000017899 -----------------------------------------------------------M DFSKCLYNIGEQLDSDELASLKFLSLD--YIPQKKQEPIKDPLMLFQRLQEKRMLEE--- ----------SNLFFLKELLFRINRLDLLMTYLDTSKEDMQQELQIPG------------ -----------------------------------------RAQISAY------------ --------------------------------------------------------RVML FQISEDVSKLELKSFKFLLSREI--------SRCKLDDDLN--LLDIFIEMEK------- --------RV-ILGERNLDTLKRICDQ-INKSLLKKITDYEELNREQTMNLQRS--LDEI SNDMSQLPIRE------------------------------------------------- ----------------------------------GSVKILPMSDSLGEQ----------- ------------------------------------------------------------ -DYESETSDKVYR--MKSKPRGYCLIFNNYDFSVA----RREVPKLQSIKDRNGT-DLDA DAL-SKTFSELHFEIVHFKDATAKKICEVLQSYQSM-D-HSSKDCFICCILSHGDK---- ---G-IIYGSDGQEAPIYELTSYFTGSKCPSLAGKPKIFFIQ--ACQGDKY-QKGIAVET --DS------EQKEAYLEM---------D-S-----------SYQKRYIP-----EDADF LLGMATVN--NCVSYRNPMEGTWYIQSLCQSLRERCP-RG-----EDIL----------- TILTEVNFEVSNKDD-------RKNMGKQMPQPTFTLRKKLFF---PP---N-------- --------- >A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------IPVSKSVD-------------- ------------------------------------------------------------ ---SVIEADESYR--MDHPEMGLCILVNNKNFHPA-----------TGMSYRSGT-DRDA AHV-VDTFRTLGYMVKPYNDLTCKQIVDVLHNVSKD-D-HHKRNSFVCVLLSHGED---- ---G-LIYGTDG-HVELKMLTSFFRGDKCKSLAGKPKLFFIQ--ACRGTEL-DSGIETDS ---------AS-----------------D-------------ESMCQKIP-----VEADY LYAYSTAP--GYYSWRNSSDGSWFIQSLCSMLKQYSH-K------LELM----------- QILTRVNRKVT-EFTSCSNH-PDFHGKKQIPCIMSMLTKDFYFPH--------------- --------- >G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------QVNGA-RLTSAQDVA--AEEGGPTGDQ--TDAK PDRRGRFLLFGNIKKN-------------------------------------------- ----------------------------------KDGQTREQDYSSES------------ ------------------------------------------------------------ -HYRVVSPTFQYK--MSHQRVGKCIIINNKNFDEK-----------TGMNVRNGT-DRDA GEL-FKCFKSLGFDVFIYNDQTCGKMESLLREASEE-D-HSDSSCFACILLSHGEE---- ---G-MIYGTDA-AMPIKSMTSLFRGDMCKSLVGKPKLFFIQ--ACRGSEF-DDGIQTDS ---------GPPN-DTLET---------D-------------ANPRHKIP-----VEADF LFAYSTVP--GYYSWRNPGRGSWFVQALCNVLNEFGK-Q------LEIM----------- QILTRVNYMVATSFESWSED-PRFSEKKQIPCVVSMLTKELYFN---------------- --------- >T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------RMETDAFYG---------- ------------------------------------------------------------ -RNSIVDPAEEYK--MDNKRRGLAIIFNQESFFWR-----------LGLKDRHGT-NADS YNL-QRRLRELNFDVNVYNNYKQQEVLDIINAAAKA-D-HSDVDCFLLVFLSHGEN---- ---D-HIYANDD-KISIQDITSLFKGDKCKSLVGKPKIFIWQ--ACRGDKH-DEPATAAA -FDDVDSE---SKKNEVEV---------D-------------ASAVHTLP-----AGADF IMCYSVAE--GYYSHRETVNGSWYIQDLCDLLLRYGD-S------LEFT----------- ELLTLVNRKVSMRSVGYCRD-PNAIGKKQVPCFASMLTKKLYFR--PK---KKSK----- --------- >M_domestica_ENSMODP00000036251 -----------------------------------------------------MEDNSKI KFNQQLLSINEKLEPEEIEALKFLCSD--LISPRNLEDIESGHQLFQKFMDEDLLNE--- ----------GDYFLVAELLFLIKHHNLLQK-IGYTKEKVKKELSS-------------- -----------------------------------------KRKISSY------------ --------------------------------------------------------RVML YNLSEEITTEDFEHIKFIMKEHI--------PKTLKT------FLSLLRHMEK------- --------QN-LLSENNLEILVNICKP-LSINLIKRIEQYKSEKGELPEFELIP------ --YHGCGVISEQVSLMTFLSLLP------------------------------------- ---------------------LFSWSRKHLPFSQQNEANNSLEEVTGLWAQGAEGGTL-- ------------------------------------------------------------ -FSDMTNEAKFYR--MDHSHRGHCIIFNNFEFQT--------------MKRRRGS-CKDA DEL-KSVFEWLGFTVKIHPNTEKREMEDILQQCSTSPE-HRESDCFVCCVLTHGES---- ---G-SVFSSDEEKIAIRELTSYFKAHRCPGLANKPKLFFFQ--ACQGPDI-QESMLLEE --DA-------KISPPIQV-----------------------ETPQRYIP-----VEADF LLGMATVD--GCCAIRHTIKGSWYIQALCHRLKCMVP-RN-----EDIL----------- TILTEVNNDVSQLTD-------AEGKKKQMPQPAFTLRKKVVF---PV---PPLSP---- --------- >R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MDNNETS--VDSK SINNF------------------------------------------------------- ----------------------------------ETKTIHGSKSMD-------------- ------------------------------------------------------------ ---SGIYLDSSYK--MDYPEMGLCIIINNKNFHKS-----------TGMSARNGT-DVDA ANL-RETFMALKYEVRNKNDLTREEIMELMDSVSKE-D-HSKRSSFVCVILSHGDE---- ---G-VIFGTNG-PVDLKKLTSFFRGDYCRSLTGKPKLFIIQ--ACRGTEL-DCGIETDS ---------GTD----------------D-------------DMACQKIP-----VEADF LYAYSTAP--GYYSWRNSRDGSWFIQSLCAMLKLYAH-K------LEFM----------- HILTRVNRKVATEFESFSLD-ATFHAKKQIPCIVSMLTKELYFYH--------------- --------- >H_sapiens_ENSP00000351273 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM DFSRNLYDIGEQLDSEDLASLKFLSLD--YIPQRKQEPIKDALMLFQRLQEKRMLEE--- ----------SNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPG------------ -----------------------------------------RAQISAY------------ --------------------------------------------------------RVML YQISEEVSRSELRSFKFLLQEEI--------SKCKLDDDMN--LLDIFIEMEK------- --------RV-ILGEGKLDILKRVCAQ-INKSLLKIINDYEEFSKERSSSLEGS--PDEF SNGE-------------------------------------------------------- ----------------------------------ELCGVMTISDSPREQ----------- ------------------------------------------------------------ -DSESQTLDKVYQ--MKSKPRGYCLIINNHNFAKA----REKVPKLHSIRDRNGT-HLDA GAL-TTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-D-HSNMDCFICCILSHGDK---- ---G-IIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQGDNY-QKGIPVET --DS------EE-QPYLEM---------DLS-----------SPQTRYIP-----DEADF LLGMATVN--NCVSYRNPAEGTWYIQSLCQSLRERCP-RG-----DDIL----------- TILTEVNYEVSNKDD-------KKNMGKQMPQPTFTLRKKLVF---PS---D-------- --------- >E_caballus_ENSECAP00000013268 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GEEQNMTEIDAFYK---------- ------------------------------------------------------------ --REMFDPAEKYK--MDHKRRGIALIFNHERFFWH-----------LTLPDRRGT-SADR DNL-MRRFSDLGFEVKCFNDLKAEELLLKIYEVSTS-S-HADADCFVCVFLSHGEG---- ---N-HIYAYDA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACRGDQH-DVPVTPL- --DVVDHGTDKLDANVTQV---------D-------------AASVYTLP-----AGADF LMCYSVAE--GYYSHRETINGSWYIQDLCEMLARFGS-S------LEFT----------- ELLTLVNRKVSQRRVDFCKD-PSAIGKKQVPCFASMLTKKLHFF--PK---SK------- --------- >D_rerio_ENSDARP00000019984 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MDKEALTSE NEVSGDDQENYGKGDVTDAKPDPKAMCRVDKE-ALTSEIEVLEEDQDSYGEEDV--TDAK PDRKGRFRLFGN-FKK-------------------------------------------- ----------------------------------NDGKLQEKG-ESES------------ ------------------------------------------------------------ -HYRIVSPTFQYK--MSHQRVGKCIIINNKNFDEK-----------TGMNVRNGT-DRDA GEL-FKCFKSLGFDVAVYNDQTCRNMERLLKAVSEE-D-HSDSSCFACILLSHGEE---- ---G-MIYGTDG-AMPIKTMTSLFKGDVCKSLVGKPKLFFIQ--ACRGSEF-DDGVQTDS ---------GPPN-DTIET---------D-------------ANPRHKIP-----VEADF LFAYSTVP--GYYSWRNPGRGSWFVQALCNVLSEFGK-Q------LEIM----------- QILTRVNYMVATSFESWSED-PRFSEKKQIPCVVSMLTKELYFN---------------- --------- >H_sapiens_ENSP00000312664 ------------------------------------------------------------ ---------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKK--- ----------NRVVLAKQLL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSELLEHLLE------- --------KD-IITLEMRELIQAKVGS--FSQNVELLNLLPKRGPQAFDAFCEA--LRET KQGHLEDMLLTTLSG--LQ------------------------------HVLPPLSCDYD LSLPFPVCESC-----------------PLYKKLRLST-DTVEHSLDNKDGPVCLQVK-- ---------------------------------------------------------PCT PEFYQTHFQLAYR--LQSRPRGLALVLSNVHFTGE-----------KELEFRSGG-DVDH STL-VTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPA-HRVTDSCIVALLSHGVE---- ---G-AIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQ--ACRGDET-DRGVDQQ- --DGKNHAGSPGCEESDA----------GKE-----------KLPKMRLP-----TRSDM ICGYACLK--GTAAMRNTKRGSWYIEALAQVFSERAC-D------MHVA----------- DMLVKVNALIKDREGYAPG--TEFHRCKEMSEYCSTLCRHLYLF--PG---HPPT----- --------- >P_troglodytes_ENSPTRP00000033921 ------------------------------------------------------------ ---------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKK--- ----------NRVVLAKQLL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSELLEHLLE------- --------KD-IITLEMRELIQAKVGS--FSQNVELLNLLPKRGPQAFDAFCEA--LRET KQGHLEDMLLTTLSG--LQ------------------------------HVLPPLSCDYD LSLPFPVCESC-----------------PLYKKLRLST-DTVEHSLDNKDGPVCLQVK-- ---------------------------------------------------------PCT PEFYQTHFQLAYR--LQSRPRGLALVLSNVHFTGE-----------KELEFRSGG-DVDH STL-VTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPA-HRVTDSCIVALLSHGVE---- ---G-AIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQ--ACRGDET-DRGVDQQ- --DGKNHAGSPGCEESDA----------GKE-----------KLPKMRLP-----TRSDM ICGYACLK--GTAAMRNTKRGSWYIEALAQVFSERAC-D------MHVA----------- DMLVKVNALIKDREGYAPG--TEFHRCKEMSEYCSTLCRHLYLF--PG---HPPT----- --------- >P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MSSASGLRRGH----------- ------------------------------------------------------------ ----------------------------------PAGGEENMTETDAFYK---------- ------------------------------------------------------------ --REMFDPAEKYK--MDHRRRGIALIFNHERFFWH-----------LTLPERRGT-CADR DNL-TRRFSDLGFEVKCFNDLKAEELLLKIHEASTV-S-HADADCFVCVFLSHGEG---- ---N-HIYAYDA-KIEIQTLTGLFKGDKCHSLVGKPKIFIIQ--ACRGNQH-DVPVIPL- --DVVDNQTEKLDTNITEV---------D-------------AASVYTLP-----AGADF LMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKYGS-S------LEFT----------- ELLTLVNRKVSQRRVDFCKD-PSAIGKKQVPCFASMLTKKLHFF--PK---SN------- --------- >M_mulatta_ENSMMUP00000037892 VEGGRRARVVTESKRNFFLGACPTPFPTEHVELGRLGGSETAMVPGKGGADYILLPFEEM DFNRNLYDIGEQLDSEELASLKFLSLD--CIPQRKQEPIKDALMLFQRLQEKRMLEE--- ----------NNLSFLKELLFRINRLDLLTTYLNTRKEEMERELQAPG------------ -----------------------------------------RAQISAY------------ --------------------------------------------------------RVML YQISEEVGRSELRSFKFLLQEEI--------SKCKLDDDMN--LLDIFVEMEK------- --------RV-ILGEGKLDILKRVCAQ-VNKSLLKIINDYEEFSRERTRSLEGS--PEEG SNGE-------------------------------------------------------- ----------------------------------ELCGLMTISDSPREQ----------- ------------------------------------------------------------ -DSESQTLDKVYQ--MKSKPRGYCLIINNYDFTKA----REKVPKLHSIRDRNGT-HLDA EAL-TATFEELHFEIQHHNDCTVEKIYKILKTYQLM-D-HSNKDCFICCILSHGDK---- ---G-IIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQGDNY-QKGIPVET --DS------EE-QPYLEM---------DLS-----------SPQTRYIP-----DEADF LLGMATVN--NCVSYRNPAEGTWYIQSLCQSLRERCP-RG-----DDIL----------- TILTEVNYEVSNKDD-------KKNMGKQMPQPTFTLRKKLVF---PS---D-------- --------- >A_carolinensis_ENSACAP00000001629 ------------------------------------------------------------ -FRQILLAIDENLGKEDVDAMKFLCSD--FISTKHLEGVETAQDIFQLLINRNLLSK--- ----------EDTFIVAELLYRIKCHFLLQK-IGYTQQKVEHNLFH-------------- -----------------------------------------IRNVSEY------------ --------------------------------------------------------RQML YEISEGFTEENVKTAMFLLREHL--------PKKQSI------AVKLLTSLEK------- --------QD-LLAEDKLAILEKICNK-VSPELRNKVDKFKERSVFKAFVFSLC--YENL YPSNFLAV---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -FLLILQASTCYK--MDGLNRGSCLIFNNVHFEGG-------------LSQRRGS-QKDA EEL-ESVFRWLGLDVIKYNDTTSIEMENHLKQWQSFEN-WKDMDCLVCCILSHGES---- ---G-KIYGTDGNLIPIRTIMSYFTAKQCPQLAKKPKLFFIQ--ACQGEKT-QQPVYLET --DDEYGSFPL-------------------------------QQMISSIP-----EEADF LLGMATVD--GYLSFRHVHQGTWYIQALCDKLRTLVP-RG-----EDIL----------- SILTEVNADVSRRAD-------AQGQKKQMPQPAYTLRKKLIF---PI---P-------- --------- >M_mulatta_ENSMMUP00000016588 ------------------------------------------------------------ ---------------------------------------RILGVCGMHPHHQETLKK--- ----------NRVMLAKQLL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSELLEHLLE------- --------KD-IITLEMRELIQAKVGS--FSQNVELLNLLPKR-PQAFDAFCEA--LRET KQGHLEDIELKLRVS--AL------------------------------MKPTGLGSDYN DILGLMVKLNT------------------VFWFSVYTT-DTVEHSLDNKDGPVCLQVK-- ---------------------------------------------------------PCT PEFYQTHFQLAYR--LQSRPRGLALVLSNVHFTGE-----------KELEFRSGG-DVDH STL-VTLFKLLGYDVHVLRDQTAQEMQEKLQNFARLPA-HRVTDSCIVALLSHGVE---- ---G-AIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ--ACRGDET-DRGVDQQ- --DGKNHAGSPGCEESDA----------GKE-----------KLPKMRLP-----TRSDM ICGYACLK--GTAAMRNTKRGSWYIEALAQVFSERAC-D------MHVA----------- DMLVKVNALIKDREGYAPG--TEFHRCKEMSEYCSTLCRHLYLF--PG---HPPT----- --------- >P_troglodytes_ENSPTRP00000021879 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM DFSRNLYDIGEQLDSEDLASLKFLSLD--YIPQRKQEPIKDALMLFQRLQEKRMLEE--- ----------SNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPG------------ -----------------------------------------RAQISAY------------ --------------------------------------------------------RVML YQISEEVSRSELRSFKFLLQEEI--------SKCKLDDDMN--LLDIFIEMEK------- --------RV-ILGEGKLDILKRVCAQ-INRSLLKIINDYEEFSKERSSSLEGS--PDEF SNGE-------------------------------------------------------- ----------------------------------ELCGVMTISDSPREQ----------- ------------------------------------------------------------ -DSESQTLDKVYQ--MKSKPRGYCLIINNHNFAKA----REKVPKLHSIRDRNGT-HLDA GAL-TTTFEELHFEIKPHDDCTVQQIYEILKIYQLM-D-HSNMDCFICCILSHGDK---- ---G-IIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQGDNY-QKGIPVET --DS------EE-QPYLEM---------DLS-----------SPQTRYIP-----DEADF LLGMATVN--NCVSYRNPAEGTWYIQSLCQSLRERCP-RG-----DDIL----------- TILTEVNYEVSNKDD-------KKNMGKQMPQPTFTLRKKLVF---PS---D-------- --------- >G_aculeatus_ENSGACP00000016969 ------------------------------------------------------------ MDRLKLSRIDEDLESSEVASLCFLCRD--VLARKRLEGINNARDLFLRLEENGLL----- ----------ENNSFLFELLQTIRRTDLLNLLESDSSPPEEADA---------------- -----------------------------------------NPILSDY------------ --------------------------------------------------------RVML YRVDQDITRENLSMMKFLLSSQL--------GKRQMEMCNT--ALDVFAEMEK------- --------TG-SLSPTSLHEVHAAVKQ-FDQQLALTIQRYIDN-RGTATPRPHR--PIHP QPV--------------------------------------------------------- ----------------------------------DVSISETQSNCSSDEGMNICSDAE-- ---------------------------------------------------------PNT KPSSPDDHTEYYA--LIHKPRGLCVVINNEDFLGT------------QMKNRKGTQEDDT EAL-CSLFSRLGFTMLVHNNLTAGAMKQELQKLGAR-N-FVNDDALVVCVLSHGEM---- ---E-CVFGTDEQRVNITDLTRPFTSEGAPTLAGKPKLFFIQ--ACQGTRY-QGGSLPHP ---SLPGQEEGVPQSPLEE---------DAG-----------PIKGETVP-----WEADF LLGMATVP--QCKSFRSTTTGSIYIQEVCTQLKKSAESSAN----DDIL----------- TVLTRVNREVSKGKY---------LNSKQMPQPKYTLTKKLVLK--YV------------ --------- >G_gallus_ENSGALP00000019870 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MSGAERRPAAGRVQ--LDSK PTPTT------------------------------------------------------- ----------------------------------TADGNQNITEVDAFDK---------- ------------------------------------------------------------ --RQTFDPAVQYK--MNHQRRGVALIFNHEHFFWH-----------LRLPDRRGT-LADR NNL-KRSLTDLGFEVRIFDDLKAEDVLKKVFEASRD-D-YSNADCFVCVFLSHGEN---- ---D-HVYAYDA-QIKIETITNMFRGDKCQSLVGKPKIFIIQ--ACRGDKH-DDPVLVQ- --DSVDSK-DETTVNQTEV---------D-------------AAGVYTLP-----AGADF IMCYSVAQ--GYFSHRETVNGSWYIQDLCEALGKHGS-S------LEFT----------- ELLTVVNRKVSHRKVDICRD-INAIGKKQIPCFASMLTKKLYFH--PK---SK------- --------- >G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------DKYRYK--MDYPCMGTCVIINNKTFDPK-----------TGLSPRNGT-DVDA AEL-EKTFSRLGYKVTVANDQTADQMVDLLADVSKQ-D-HRKSASFVCALLSHGDE---- ---D-GIYGTDG--TSLDDLTKFFKGDRCRSLVGKPKLFFIQ--ACRGTDT-DRGVNFDA ---------DST----------------D-------------GQMLQSIP-----LEADF LYAYSTPS--GYYSWRNTQNGSCFMQSLCEILHSFS--Q------LELM----------- QIMTRVNYEVALHFESSSDK-LGYSGKKQIPCIMSMLTKDFYFPK--------------- --------- >D_melanogaster_FBpp0084848 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MDATNNGESADQVGIRVGNPEQPNDHTDALGS--VGSG GAGSSGLVAGSSHPYGSGAIGQL------------------------------------- ----------------------------------ANGYSSPSSSYRKNVA---------- ------------------------------------------------------------ -KMVTDRHAAEYN--MRHKNRGMALIFNHEHFEVP------------TLKSRAGT-NVDC ENL-TRVLKQLDFEVTVYKDCRYKDILRTIEYAASQ-N-HSDSDCILVAILSHGEM---- ---G-YIYAKDT-QYKLDNIWSFFTANHCPSLAGKPKLFFIQ--ACQGDRL-DGGVTMQR --------------SQTET---------DGD-----------SSMSYKIP-----VHADF LIAYSTVP--GFYSWRNTTRGSWFMQSLCAELAANGK-R------LDIL----------- TLLTFVCQRVAVDFESCTPDTPEMHQQKQIPCITTMLTRILRFS--DKQLAPAGRV---- --------- >T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SMQMAGEPTEISDLGGEVEEGGQSEDD--VDAK PDRKGRFLLFKS-KKN-------------------------------------------- ----------------------------------KDGQMREQDYCSES------------ ------------------------------------------------------------ -HYRIVSPTFQYK--MSHQRVGKCIIINNKNFDEK-----------TGMNVRNGT-DRDA GEL-FKCFKTLGFDVFIYNDQTCEKMERLLREASEE-D-HSDSSCFACILLSHGEE---- ---G-MIYGTDG-AMPIKTMTSMFRGDMCKSLVGKPKLFFIQ--ACRGSEF-DDGIQTDS ---------GPPN-DTMET---------D-------------ANPRHKIP-----VEADF LFAYSTVP--GYYSWRNPGRGSWFVQALCNVLSEFGK-Q------LEIM----------- QILTRVNYMVATSFESWSED-PRFSEKKQIPCVVSMLTKELYFK--QC------------ --------- >P_troglodytes_ENSPTRP00000048878 ------------------------------------------MKSQGQHWCSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCIG--LVP-KKLEKSSSASDVFEHLLAEDLLSE--- ----------DDPFFLAELLYIIRQKKLLQH-LNYTKEEVERLLPT-------------- -----------------------------------------RQRVSLF------------ --------------------------------------------------------RNLL YELSEGIDSENLKDMIFLLKDSL--------PKTEMT------SLSFLAFLEK------- --------QG-KIDEDNLTCLEDLCTT-VVPKLLRNIEKYKREKAVQIVTPPVD--KEAE S-YQGEEELVSQTDVKTFLEALP------------------------------------- --------------------Q-ESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLN-- ------------------------------------------------------------ -SETSTKRATVYR--MNRNHRGLCVIVNNHSFTS--------------LKDRQGT-HKDA EIL-SHVFQWLGFTVHIHNNVTKVEMEEVLQRQKCNPA-HADGDCFVFCILTHGRF---- ---G-AVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQ--ACQGEEI-QPSVSIEA --DALNPEKAP-------------------------------TSLQDSIP-----AEADF LLGLATVP--GYVSFRHVEEGSWYIQSLCNHLKKLVP-RM-----LKFLEKTMEIRGRKR TVWGAKQTQISATSL-------PKAISAQTPRPPMHRWSSVS------------------ --------- >A_aegypti_AAEL014348-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MKKIMFGRKE-------------- ------------------------------------------------------------ ----------------------------------VNSPQQMIPTVAP------------- ------------------------------------------------------------ -AYTIERYSAYYP--MNHKHRGKAIIFAHSVFAVK----------NVNLPNRDGS-DVDC EML-VESLKRLHFDVTLYKDYRLKDILLVIEKVSLM-D-HSNSDCLLVAVLSHGDE---- ---GEVIYAHDC-PYQISSIWTQFTGDRCRTLVGKPKIFIIQ--ACRGNDL-DSGVKVEK ----------------------------D-------------GVARYSIP-----TNADF LFAFATIP--GYMSFRNTKNGSWFIRELCNELNENGQ-R------YDML----------- TLLTFVVQKVAYGYESYAPVHPDHHMKKQTPCVVSMLTRLLLFN--NV------------ --------- >H_sapiens_ENSP00000265164 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MSSASGLRRGH----------- ------------------------------------------------------------ ----------------------------------PAGGEENMTETDAFYK---------- ------------------------------------------------------------ --REMFDPAEKYK--MDHRRRGIALIFNHERFFWH-----------LTLPERRGT-CADR DNL-TRRFSDLGFEVKCFNDLKAEELLLKIHEVSTV-S-HADADCFVCVFLSHGEG---- ---N-HIYAYDA-KIEIQTLTGLFKGDKCHSLVGKPKIFIIQ--ACRGNQH-DVPVIPL- --DVVDNQTEKLDTNITEV---------D-------------AASVYTLP-----AGADF LMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKYGS-S------LEFT----------- ELLTLVNRKVSQRRVDFCKD-PSAIGKKQVPCFASMLTKKLHFF--PK---SN------- --------- >P_pygmaeus_ENSPPYP00000014606 -----------------------------------------------------------M DFSRNLYDIGEQLDSEDLASLKFLSLD--YIPQRKQEPIKDALMLFQRLQEKRMLEE--- ----------SNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPG------------ -----------------------------------------RAQISAY------------ ------------------------RFHFCRMSWAEANSQCQTQSVPFWWRVDHILIRVML YQISEEVSRSELRCFKFLLQEEI--------SKCKLDDDMN--LLDIFIEMEK------- --------RV-ILGKGKLDILKRVCAQ-INKSLLKIINDYEEFSR--------------- --GE-------------------------------------------------------- ----------------------------------ELCGVMTISDSPREQ----------- ------------------------------------------------------------ -DSESQTLDKVYQ--MKSKPRGYCLIINNHNFAKA----REKVPKLHSIRDRNGT-HLDA GAL-TTTFEELHFEIKPHNDCTVEQIYEILKIYQLM-D-HSNMDCFICCILSHGDK---- ---G-IIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQGDNY-QKGIPVET --DS------EG-QPYLEM---------DLS-----------SPQTRYIP-----DEADF LLGMATVN--NCVSYRNPAEGTWYIQSLCQSLKERCP-RG-----DDIL----------- TILTEVNYEVSNKDD-------KKNMGKQMPQPTFTLRKKLVF---PS---D-------- --------- >D_rerio_ENSDARP00000063081 ------------------------------------------------------------ ---------------------------------------------MSKKESTQRILQ--- ----------HKVFLIDTLSVE-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ASFILQNVQQ------- --------AK-LITQRDYNNLSDVSER--ETKIIKLLDKLIGRGEETCQEFIDL--LR-- ------------------------------------------------------------ ----------------------------------QDCVLENFPVLEGHAI---------- ------------------------------------------------------------ -FASSVQKVSQYK--ITQNPRGICVIINNVDFT--------------SMGERRGS-DEDQ NYL-AKVFRWLGFEVVAHRNKTAAEMKNILQALGRT----VDGDCFVCCVLSHGVE---- ---E-GVCGTDGSLVSVDEIRNPFTGVNCQKLVGKPKLFFIQ--ACRGQRK-QLRVNAQA --DG-----PGDGESEMEV---------D-G-----------DDFDITIP-----SDTDF LIARSTTD--GHVSYRKPDEGSWFIQSLCRNLEKHCPLG------ADIL----------- TILLSVNNEVSIQGL----------HSKQMPVHEVAMRMKLILP--PV---NN------- --------- >G_aculeatus_ENSGACP00000005791 -----------------------------------------------------------M HFQKLLFDIGKALSGEEVKALAFLCTD---ILGRNLSSVESASGLFSRLRDQGFLSA--- ----------EQPHLLTELLIIIQRVRLTRDVDLPAEP---------------------- -----------------------------------------SSLISPY------------ --------------------------------------------------------RKML YNLSEELTADDLKDMKFLLHSYL--------PRRKLEENVS--TLEIWLEMEH------- --------KD-LMNEHNLHLLEILISK-VCPMLKDKINQLKAQQETPTSPATQE--SGRQ GSLSAPNAPNQVPQSLGAEGTGL------------------------------------- -------FEMQDSPSGFNGGGDCAALSLGLSGHLKIEVVETMPPPKNMSCSEPPTSQP-- ------------------------------------------------------------ -SDTNTEVLGTYP--MTSAKRGICLIVNNFDFTKF-----------KNYQNREGT-MKDE ERL-HKVFAWLGFEVEVKHDCEGEQMLTALRELASR-N-HGQADCLVCCVLSHGDE---- ---G-CVYGVDGHTVAIKELKEPFNGLNCASLAGKPKLFFIQ--ACQGTGE-QKAVNVVP --DG-------PEDSAVCS---------D-A-----------FKASDAIP-----SEADF LLGMSTVP--SFVSYRHRKNGSWFIESLCQNLVQMVP-K---------L----------- ------------------------------------------------------------ --------- >P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MSSVSGLRRGH----------- ------------------------------------------------------------ ----------------------------------PAGGEENMTETDAFYK---------- ------------------------------------------------------------ --REMFDPAEKYK--MDHRRRGIALIFNHERFFWH-----------LTLPERRGT-CADR DNL-TRRFSDLGFEVKCFNDLKAEELLLKIHEVSTV-S-HADADCFVCVFLSHGEG---- ---N-HIYAYDA-KIEIQTLTGLFKGDKCHSLVGKPKIFIIQ--ACRGNQH-DVPVIPL- --DVVDNQTDKLDTNITEV---------D-------------AASVYTLP-----AGADF LMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKYGS-S------LEFT----------- ELLTLVNRKVSQRRVDFCKD-PSAIGKKQVPCFASMLTKKLHFF--PK---SN------- --------- >C_familiaris_ENSCAFP00000005409 ------------------------------------------------------------ ---------------MAAASAGRPAALQRKAPTAAGRGRRILGVCGMHPDHQEALKK--- ----------NRVVLAKQLL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSELLEHLLE------- --------KD-IITLEMREHIQAKVGG--FSQNVELLNLLPKRGPQAFDAFCVA--LRET KQGHLEDLLLTTLSG--LQ------------------------------HGLPPLSCDYD LSLTFPMCESC-----------------PPQKQLRLSP-DTVEHSLDNGDGPPCLQVK-- ---------------------------------------------------------PCT PEFYQTHYQLAYR--LQSRPRGLALVLSNVHFTGE-----------KDLEFRSGG-DVDH STL-VTLFKLLGYKVHVLLDQTAQEMKEKLQNFAQLPA-HRVTDSCIVALLSHGVE---- ---G-GIYGVDGKLLQLQEVFRLFDNASCPNLQNKPKMFFIQ--ACRGDET-DRGVDQQ- --DGKNHTGSSECEESDA----------SKE-----------ELLKTRLP-----TRSDM ICGYACLR--GTAAMRNTKRGSWYIEALTQVFSERAC-D------THVA----------- DMLVKVNALIKEREGYAPG--TEFHRCKEMSEYCSTLCRHLYLF--PG---HPPT----- --------- >R_norvegicus_ENSRNOP00000016613 -----------------------------------------------------------M DFHSCLYDIAERLGNEELAALKFLCLD--HIPQKKQESINDVLVLFQRLQEEGMLEE--- ----------DNLSFLKELLFHISRRDLLSRVLKSSPEEMVRELQVLG------------ -----------------------------------------KAQVSAY------------ --------------------------------------------------------RVML FKLSEDMDKEDLKSFKFLLITEI--------PKCKLQDNSS--LLDIFVEMEK------- --------RT-ILAENNLVTLKSICFR-VNRSLLGRIDDYERSSTERRMSTEGG--EELP VSVLDE------------------------------------------------------ ----------------------------------VTIKMQDMWDSPGEQ----------- ------------------------------------------------------------ -ESESLNSDNVYQ--MKSKPRGYCLIFNNNNFSKA----REDIPKLSNMRDRKGT-NYDE EAL-SKTFKELHFEIVSFSDCTASQIHEVLVSYQSK-D-HKGKDCFICCILSHGDK---- ---G-IVYGTDGKEASIYELTSYFTGSKCPSLAGKPKIFFIQ--ACQGNNF-QKAVPVPD ETGL------EQ-EHVLEE---------D-S-----------SSYKNYIP-----DEADF LLGMATVK--NCVSYRDPTRGTWYIQSLCQSLRERCP-RG-----EDIL----------- SILTGVNYDVSNKDN-------PRNMGKQMPQPIFTLRKKLFF---PP---N-------- --------- >C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MGEQRNTSSKELAAAEATGQSGKELEVSMENTENS--VDAK SFKNA------------------------------------------------------- ----------------------------------ETVIV---KILK-------------- ------------------------------------------------------------ ---DKYLTKLHYK--MDYPEMGLCIIINNKNFHKS-----------TGMAPRSGT-DVDA ANL-RETFTNLKYEVRNKNDLTCEEILELMNSVSKE-D-HSKRSSFVCVLLSHGDE---- ---G-IIFGTNG-PVDLRKVTGFFRGDYCRSLTGKPKLFIIQ--ACRGTEL-DCGIETDS ---------GIE----------------D-------------DMACQKIP-----VEADF LYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKLYAH-K------LEFM----------- HILTRVNRKVATEFESFSLD-SAFHGKKQIPCIVSMLTKELYLYH--------------- --------- >E_caballus_ENSECAP00000004055 -----------------------------------------------------------M NFNSCLYNIGEQLDSDELASLKFLSLD--HIPQRKQEPIQDALMLFQRLQEKRLLEE--- ----------SNLSFLKELLFRINRLDLLTTELDTSKEEMERELQSPG------------ -----------------------------------------RAQISAY------------ --------------------------------------------------------RVML FQISEDVNKLELKSFKFLLSREL--------PKCRLDDDMI--LLDIFIEMEK------- --------RV-MLGERNLDTLKKICEQ-VNKSLLKKINDYEELSREGRISLERS--PDEF SNASLKCLQRE------------------------------------------------- ----------------------------------GSLAGQAMSDSPGQQ----------- ------------------------------------------------------------ -NSESQTSDKVYR--MESKPRGYCLIFNNHDFSAA----RRDVPKLQNIKDRNGT-DLDA EAL-SMTFTELHFEVVPYKNSTAKDICDALREYQEM-D-HKKKDCFICCILSHGDK---- ---G-IIYGCDGQEASIYELTSYFTGSNCPSLAGKPKIFFIQ--ACQGDNY-QKGIAVET --DS------ELTDAYLEM---------D-S-----------SFQKRCIP-----DEADF LLGMATVN--NCVSYRNPLEGTWYIQSLCQSLRERCP-RG-----EDIL----------- TILTNVNFEVSSKDD-------KKNMGKQMPQPTFTLRKRLVF---PL---N-------- --------- >G_gallus_ENSGALP00000029853 ------------------------------------------------------------ ------------------------------------------GACGMQRYHQEALKK--- ----------NRVMLARELV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LKELMEHMIE------- --------KD-IITIEMVEMIQAKSGS--FSQNVEFLNLLPKRGPNAFSAFCEA--LQET KQQHLAEMILKTESS--LR------------------------------HGIATLEQRYG SNLPLPLSESC--------------NSKRPRLIVFFCT-KPVEHSLDSGDGPPIPPVK-- ---------------------------------------------------------HCT PEFYRDHQHLAYK--LISEPRGLALILSNIHFSSE-----------KDLEYRSGG-DVDC ASL-ELLFKHLGYQVTVFHDQSAEEMESALERFSKLPD-HQDVDSCIVALLSHGVE---- ---G-GVYGTDGKLLQLQEAFRLFDNANCPNLQNKPKMFFIQ--ACRGDET-DRGVDQR- --DGKEWSDSPGCEESDA----------NKE-----------ENLKLRLP-----TRSDM ICGYACLK--GTAAMRNTKRGSWYIEALTTVFAEDSR-D------THVA----------- DMLVKVNRQIKQREGYAPG--TEFHRCKEMSEYCSTLCRDLYLF--PG---YVPGK---- --------- >P_pygmaeus_ENSPPYP00000020323 ------------------------------------------------------------ ---------------MAAPTAGSWSTFEHKELMAADRGRRILGVCGMHPHHQETLKK--- ----------NRVVLAKQLL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSELLEHLLE------- --------KD-IITLEMRELIQAKVGS--FSQNVELLNLLPKRGPQAFDAFCEA--LRET KQGHLEDMLLTTLSG--LQ------------------------------HVLPPLSCDYD LSLPFPVCESC-----------------PLYKKLRLST-DTVEHSLDNKDGPVCLQVK-- ---------------------------------------------------------PCT PEFYQTHFQLAYR--LQSRPRGLALVLSNVHFTGE-----------KELEFRSGG-DVDH STL-VTLFKLLDYDVHVLCDQTAQEMQEKLQNFAQLPA-HRVTDSCIVALLSHGVE---- ---G-AIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQ--ACRGDET-DRGVDQQ- --DGKNHAGSPGCEESDA----------GKE-----------KLPKMRLP-----TRSDM ICGYACLK--GTAAMRNTKRGSWYIEALAQVFSERAC-D------MHVA----------- DMLVKVNALIKDREGYAPG--TEFHRCKEMSEYCSTLCRHLYLF--PG---HPPT----- --------- >O_anatinus_ENSOANP00000006351 -----------------------------------------------------------M DFHRLLFSIGEELAADDLEALKFLCLD--LIPRKKQENIQDALGLFRLLQEKGMLEE--- ----------GKLFFLKELLFRIHRIDLLTSHLRTSQEDVARELEEPG------------ -----------------------------------------RAQVSAY------------ -------------------------------------------------------SRVLL FTLSDNVTREELKSITFFLSNDL--------PRSRLDNKQT--LMGIFIEMEK------- --------KG-ILGESNLDMLKKICDK-IDKTLLGKIDHYEERRADCTLHSSEH--LTVL DRDMYIIPIIYD------------------------------------------------ ----------------------------------EIILLPTESSFRGHS----------- ------------------------------------------------------------ -GGEAEQNGDFYK--MNSNPRGYCLIINNYNFQQA----RAEVPKLKKMKNRDGT-DKDA EAL-SQIFKALAFSPVVFEDQTAEQILETLQSYQRM-D-HSAQDCFVCCILSHGDR---- ---G-VVYGTDGQQASIRSLTSYFTGSRCPTLAGKPKLFFIQ--ACQGDAY-HLAVALET --DN-GTDKGTAAASPAEP---------D-A-----------VFHERCIP-----DEADF LLGMATVS--NCVSYRIPSKGTWYIQSLCHHLRNLCP-LG-----ADIL----------- TILTKVNFEVSQKID-------LTNRGKQMPQPMFTLRKKLVL---PL---L-------- --------- >D_rerio_ENSDARP00000093958 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MKHAKRGLALIFNQKDFSL------------LGLKTRKGT-DKDR DSL-VSRFEELDFEVKAYNDYSRDKVLKEIKEVAAA-D-HVDADCFVCIFLSHGED---- ---G-HVYANDE-KIKIPEITDLFKGDKCRGLVGKPKIFIWQNKACRGDKK-DDPVAPM- --SAEDSD------DEMAV---------D-------------AGVSNTLP-----AGADF IMCYSTTE--GFCSFRDPLNGTWYIQDLCEIMGRYRS-Q------LEFT----------- NILTLVNRKVSLRSI--CDD-LSATGTKQMPCFASMLTKRLFFR--PK---K-------- --------- >A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------PTFRYR--MDYKKLGKCVIINNKNFAKD-----------TGMRIRNGT-DKDA GDL-QKCFRGIGFDVSIYNDLTCDNMEKILGEAALE-N-HDDAACFACILLSHGEE---- ---G-LIYGTDG-CMAIKNLTGLFRGDKCQSLIGKPKLFFIQ--ACRGSEF-DAGIQTDS ---------GSSN-DNLEM---------D-------------ANPRYKIP-----VEADF LYAYSTVP--GYFSWRNPGKGSWFVQSLCSVLNDHGK-E------LEVL----------- QILTMVNYKVARNYESQSDD-PRFSQKKQVPCVVSMLTKELYF----------------- --------- >C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------ EFRLLLHQICEGLTGENVSMMKFLCKD----AIPRSRELETALDFMEYFEAKGWIQE--- ----------GDLGFLAEVLYRINRHDLLKLLPGVKNRRDYEENFQAQ------------ -----------------------------------------QNNFTTY------------ --------------------------------------------------------RVVC FMLADELTEGDLKILKRLCAGKM--------SKANVRRSVD--VLSWLTCMEE------- --------ED-LLSEGDLDFIMSILQHLDNQKPYKLFQRVRMNDNTVTLPKNQQ--KSNA FQPNSHLPVASGFNSLSKQEYNH------------------------------------- ----------------------------TSKLEPQYVSMENHRAFNGGYNQYNNYQSE-- -----------------------------------------------------------I KDTSTMGILDKYP----MERRGYCLIINNENFERQ---------------DRTGS-GNDT ERL-ENLFKEFGFILDVRKDLDQREMEKVIQEYTKK-D-HSDKDCFVCVVMSHGLS---- ---G-CVYGVDGLSLSTSKISKSFRPGMCSSLTGKPKIFFFQ--ACQGDRT-MDGHSAPV --------------DDVES---------DGAA----------SHGRQVLP-----SESDF LIGHSTVP--GYLSYRSRTDGSWFISTLVDSLEKYHE-K------EDLL----------- SIMINVNQEMASK------------PYKQMPMPIATLRKKVFFS--KQNSNSSSNQNCNT P-------- >G_gorilla_ENSGGOP00000000205 ---------------------------------------------------YILLPFEKM DFSRNLYDIGEQLDSEDLASLKFLSLD--YIPQRKQEPIKDALMLFQRLQEKRMLEE--- ----------SNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPG------------ -----------------------------------------RAQISAY------------ --------------------------------------------------------RVML YQISEEVSRSELRSFKFLLQEEI--------SKCKLDDDMX--LLDIFIEMEK------- --------RV-ILGEGKLDILKRVCAQ-INKSLLKIINDYEEFSKERSSSLEGS--PDEF SNGE-------------------------------------------------------- ----------------------------------ELCGVMTISDSPREQ----------- ------------------------------------------------------------ -DSESQTLDKVYQ--MKSKPRGYCLIINNHNFAKA----REKVPKLHSIRDRNGT-HLDA GAL-TTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-D-HSNMDCFICCILSHGDK---- ---G-IIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQGDNY-QKGIPVET --DS------EE-QPYLEM---------DLS-----------SPQTRYIP-----DEADF LLGMATVN--NCVSYRNPAEGTWYIQSLCQSLRERCP-RG-----DDIL----------- TILTEVNYEVSNKDD-------KKNMG--------------------------------- --------- >C_intestinalis_ENSCINP00000002956 ------------------------------------------------------------ ---------------------------------------------AMKKRHRNTLIK--- ----------NRVKLAKCLH---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LDEVLQYLVQ------- --------CG-ILTDVTVERITSKPTR--FSQNVAFLTCLPTRGPRAYGTFLEA--LRIS SQEHLVDILEKVDISNAIPNNKP------------------------------------- -----------ITPTTLHATITSNVHSEFVCARRQPMEIGKCEDKNDAKDGHNRLRVQ-- ---------------------------------------------------------NST VAFFNETYNSGYK--MTTKSRGYALIVCIGRFNAG-----------VRLPDRQGT-DADK KNL-LAIFEQINYKTILVENCNKFEMERRVKQFAQMEE-HRKCDSCAVAILSHGSK---- ---T-DIYASDGRSIPIESLIKMFDNVNCPPLRNKPKIFFIQ--CCRGNNM-DQGIDAT- --DGPPTLNSETS---------------DSY-----------NSTTHNIT-----TDVDI ISTASK----RNAALRNTRHGSWYIQVLVKTIAQHAH-E------MDLL----------- EILTLVNSAIKSKEGHSTD--FDSQGVKEMSEFHSTLCKKLFFY--PG---IVQTE---- --------- >T_rubripes_ENSTRUP00000044662 ---------------------------------------------------------CNM DFQARLLKVGNDLRKDEVRALVFLCSD---ILGCNPAAVQSAGDLFSRLSDQDHLSE--- ----------EQPHLLVELLGIIQRTKLLRDHNLPRTGA--------------------- -----------------------------------------QDLISPY------------ ----------------------------------------------------SCKSRKLL YSLSEELTADDLKDIKFLLNNKL--------PRGKLEEVT---TLEVFMELEH------- --------RA-LISDTDLGFLESIIQP-VCPVLLEKINQFNAQNCKMHLILHIF--DSYL NQIQLNTQLKALWLIKKFDSFLV------------------------------------- ----------------SFSSNESWIGGSGNRPTNRCPLLTAASLLEQSCSFNTLQVGC-- ------------------------------------------------------------ -PDVSVQGVETYL--MTAAKRGRCLIINNCNFRVS------------RLKKREGT-MVDE ASL-DKVLKWLGFEVEIQRDCTSKKMSSLIQELAKT-S-QRDWDCVMCCVLSHGLE---- ---G-GVYGVDGGTVEIRKLMEPFSGTNCPSLAGKPKIFFIQ--ACQGSRQ-QDIVYTDA --GT-------PGHGYVDN---------N-A-----------VQAKECIP-----SHADF LLGMATVP--SFVSFRDGTHGTWYIQSLCQNLADMVP-RG-----CDLI----------- SILTKVNADVSKKVAWI-----DSGHKTQMPQPAFTLTKKIVF---PA---PNTPHPV-- --------- >D_melanogaster_FBpp0071971 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MTDECVTRNYGVGIRSPNGSENRGSFIMADN--TDAK GCTPESLVVGGAT----------------------------------------------- ----------------------------------AASPLPANKFVA-------------- ------------------------------------------------------------ -RMPVERYASEYN--MSHKHRGVALIFNHEFFDIP------------SLKSRTGT-NVDA QEL-KKAFENLGFAVSVHKDCKLRDILKHVGKAAEL-D-HTDNDCLAVAILSHGEH---- ---G-YLYAKDT-QYKLDNIWHYFTATFCPSLAGKPKLFFIQ--ACQGDRL-DGGITLEK --------------GVTET---------DGE-----------SSTSYKIP-----IHADF LFSYSTIP--GYFSWRNINNGSWYMQSLIRELNANGK-K------YDLL----------- TLLTFVNQRVALDFESNVPATPMMDRQKQIPCLTSMLTRILRFG--DKPNGNKAG----- --------- >O_anatinus_ENSOANP00000005545 ------------------------------------------------------------ ----------------------------------------------MQPCHQEALKK--- ----------NRVALAKQLM---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSELLEHLLE------- --------KD-VITMEMRELIQAKAGS--FSQNVEFLNLLPKRGPKAFDAFCAA--LRET KQGHLQDLLYRTLSN--LSPPST----------------AVGALGTQGEELAGRLGGRWR GLPSLPSVSVCPVVVCPFLMVLGNSRLQPALSVGDLLP-EEMEHSLDNGDGPPCPQVK-- ---------------------------------------------------------PCT PEFYRVHHHLAYR--LESRPRGLALVLSNMRFNGE-----------KDLEFRSGG-DVDH NAL-ITLFKHLDYSVEFLRDQTAQEMQEKLHNFAQSPR-HRFTDSCVVALLSHGVE---- ---G-GIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQ--ACRGDET-DRGVDQR- --DGKERAASPGCEESDA----------GKE-----------EMLKVRLP-----TRSDM ICGYACLK--GTAAMRNTKRGSWYIEALTQVFAESAR-D------MHVA----------- DMLVKVS----------------------------------------------------- --------- >A_gambiae_AGAP000830-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MSMPDVVDIRNEINKEHVRESLDRNGDEQQLVQDV--NDAL GT---------------------------------------------------------- ----------------------------------RKGHDPTNHLVRA------------- ------------------------------------------------------------ -RMPVERYACDYN--MNHKRRGLALIFNHENFDVP------------QLRSRAGT-NVDC ENL-TASLKGLDFEVHVFKDLKLRDLQKEVERVSQM-D-HSDADCLLVTILSHGEL---- ---G-YLYAKDC-QYKLDTIWTYFTANHCPSLAGKPKLFFIQ--ACQGDQL-DGGVVLEA -------------KDRTET---------DSSS----------SMLTFKIP-----MYADF MIAYSTIP--GFYSWRNTQKGSWFIQSLCHELNQNGR-K------YDLM----------- VLLTFVTQRVAYDFESNTPDIPMMHQQKQIPCTTSMLTRLVYFN--QKK----------- --------- >O_cuniculus_ENSOCUP00000006164 -------------------------------ALVESGTVGDWVTVPGEGNGYXXXXXXXX XXXXXXXXXXEQLDSELL--LKF-ELD--YIPQRKQEPIQDALMLFQRLQEKRMLEE--- ----------NNLAFLKELLFRIHRLDLLSTLLGTSKEEMVTELQIPG------------ -----------------------------------------RAHISAY------------ --------------------------------------------------------XXXX XXXXXXXXXXXXXXXXXXXXXXX--------XXXXXXXXXX--XXXXXXXXXX------- --------XX-XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXX--XXXX XXXX-------------------------------------------------------- ----------------------------------XXXXXXXXXXXXXXX----------- ------------------------------------------------------------ -XXXXXTSEEVYQ--MKSKPRGYCLIVNNYDFSIA----RREMPRHRNMKDRKGT-EVDA EAL-SNTFTDLHFEVVHYNDCTAKQICDILQSYQSM-D-HKDRDCFVCCILSHGDK---- ---G-IIYGTDGQEACIYDLISYFTGSKCSSLAGKLKVFFIQ--ACQGDKY-QQAVPAI- --DS------EQ-QSYL-----------D-S-----------SFPKRYVP-----DEADF LLGMATVN--NCVSYRNLFEGTWYIQSLCQSLRERCP-QG-----EDIL----------- SILTKVNYKVSIKEA--------GEKKKQMPQPTFTLTKRLLF---PL---D-------- --------- >C_intestinalis_ENSCINP00000007986 ------------------------------------------------------------ ----------------------------------------------MLSTHKEKLRT--- ----------NRHTLCKELV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VDELLQELIG------- --------EG-IFNDILADRVLSHQRD--FKKNVEFLTLLPGRGPNAFNAFRIA--LINS DQSHLAELLDPAQGVSQPNESNANDGSGGPELSASIFRFESIATANSNLPGTSGTSAPLS RRRPMENTDQSSTSIASSQVIYANQGTPPKRNRESSSYIEQMDDAPSPTDSLSNIRSTAS VHSLFSRSDVRTQSNTAINHINTVQSPTSTKAATSYQINLHQGMDLFDGPTVSDLTVRKS THQHLMQHTDCYQMTMRGRPKGAALIISVEKFHPE-----------SDLLNREGS-EKDR VRL-ELVLQQIGFQCYVLINGTAEQIVSTLQTFAELEE-HYDNSCSLVAAMSHGDA---- ---G-CFYGSDGVSVAIDTVVNFFSNQNCHSLQKKPKIFLFQ--ACQGDEY-DMGVDEV- --DGPVQAPVGDVDNTSTS---------SSN-----------DHIRNKLP-----QKSDM LIGQATMK--GFAAMRNTKHGSWYIQAFVRVLARHAC-D------TDLL----------- DMMTKVNNILKHKEGWCPG--SVYHRCKVMPEFKSSLSKKLYFF--PG---I-------- --------- >C_elegans_Y48E1B.13a -------------------------------------------------------MVLKT IEDNCKSQFDDDLVEDFNNFQTTSSMSSSTTISTEDFNTIEIESTFEICRSGSYTEE--- ----------PILGENDEFLIDFEMERFLKFLKDKTKQVEKRKEPFSQ------------ ------------------------------------------------------------ ---------------------------------------------------------KEI YAVFQRRIKSELCIETVKKK-----------------------FQPLLPNAIQ------- -----------TCEFDEETMIRMIYGAGIRIDSVDFWNRFTSKATISLDCYSRL--ISYS SDSLTLSGTHRSGFTYHWISTPP--------------------------VTYHRTENKDP NIQEPSPVEFLDVQSSLGSSMKPPILDKPTKLDDPAETRHDCSYSLEEYDSQSRMPRT-- -----------------------------------------------------------D AKKSNHKHKYCYE--MNSNPRGTVLILSNENFK--------------NMERRVGT-KQDE VNL-TKLFQKLQYTVICKRNLEAESMLEAIKEFAEM-A-HT--DSIILFLLSHGDG---- --AG-SVFGIDDMPVNVMEVSTYLA--YHQNLLLKPKWVAVS--ACRGGKL-NMGVPV-- --DGLPALEDKCAPISKFW---------N-------------LMMSRIMPGTFTSLNADV IISFSTTD--GFTSYRDEEAGTWYIKSMCKVFNKHSK-T------MHLL----------- DILTETGRNVVTKYENV----QGNVVLKQAPEILSRLTKQWHFS--RS---M-------- --------- >G_gallus_ENSGALP00000014503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KK-------------------------------------------- ----------------------------------KNGEEEQPKSSLSN------------ ------------------------------------------------------------ -QYRIVTPTFQYN--MNYKKVGKCIIINNKNFEDK-----------TGMGTRNGT-DKDA GDL-SKSFRSLGFDVYTYNDRSCEDMQTLLKQAAEE-N-HSDAACFACILLSHGEE---- ---G-LIYGTDG-PMAIKHLTTLFRGDKCKTLIGKPKLFFIQ--ACRGSEF-DEGIQTDS ---------GPAN-DTLET---------D-------------ANPRYKIP-----VEADF LFAYSTVP--GYYSWRNPGRGSWFVQSLCSVLNEHGK-Q------LEIM----------- QILTRVNYVVATNFESQSDD-PRFSEKKQIPCVVSMLTKELYF----------------- --------- >D_rerio_ENSDARP00000075645 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MDKTSNPNNSNQINRA--SPNEQEKIKTDEPKRKNTSQEDKEN--LHKG VQN--------------------------------------------------------- ----------------------------------NNSPKRQREPLQSTCNISDHYPKR-- ------------------------------------------------------------ -KRAVTEQKEWYS--MSNRPLGYCLIINNYKFESA------------SLADRRGT-DRDK DDL-TKVFEKMYFKVEVRDDLQASDMRNVIKEFAEK-D-HSQMNAFVCCILTHGEK---- ---G-TVLGTDGKQVPIRELSQPFA--ECRSLASKPKLFFIQ--ACQGNMR-QQGLWMAH EREN------TTEEEAYEE---------DAH-----------AAGNYSIP-----MDADF LFAIATVE--HFRSYRHITNGSIFIQVLCKQLERGCAQK------KDIL----------- SILTAVNGVVGSKIL---------QGYKQMPEVRYTLTKALVL---PM---NGVS----- --------- >A_gambiae_AGAP004921-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------RSCNLMDDLPPEPTPDNEFYDGN------ ------------------------------------------------------------ ----------------------------------IPSITQTDQIASRQRS---------- ------------------------------------------------------------ -QNARALQEEEYD--TNHRRRGMAIILNHENFEL--------------MSKREGT-NRDR DAA-TAVLTSMQFDVRVYNDLGRDELFCVLLALASE-D-HSDCDCLLVMLMTHGDD---- ---D-VLYAYDG-PYSVDKLWESFMGNACTTLLGKPKLFFVQ--ACRGSTF-DKGVKLGC --------------RDLDS---------DHF-----------SSHKYVIP-----TTADL LVMYSSYK--GHVSWRSPRGGSWFIQALCVELETNWK-H------MELL----------- QLLTGVSRRVAYDYQSNEPSKGRMDAMKQMPSIVSMLTKLVYFP--LKLGS--------- --------- >A_gambiae_AGAP004754-PA ------------------------------------------------------------ ----------------------------------------------MNNKDRFLITH--- ----------NVEKLVNYTN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------YKQLSFECIQ------- --------QK-MLSPTMVSRIEGIAQD-EVTRHKKLFEKITKRGPKAFDTLLAI--CQQA FPTAYLILKPNSNDNQMHSTHNP------------------------------------- ----------------------QRVRSVSCNVAPKVYSLRSPGDVDDGKNNNFASNAL-- -----------------------------------VEESKCILQVYPDILPTTFSVKLST RPAETHPKVPAYP--MKGRNRGVAFIVNVITFLKK------------VHPTRNGA-DIDG RNL-ISVFQQLGFVVFYYEDITMGDLKELLAQLKES-E-HLSCDCFAFYILSHGDH---R KGSD-YIFLHDNSLLRVEDLLTEFNSVNCKRLVHKPKLFFIS--ICRGVQS-DLGAYRLS ----------TNTERDGMI---------DPG-----------KPLPSNIA-----TYCDM LVCYATVP--GFAAHRDTNTGSWFVESMCKIWSEHAH-D------TDVE----------- ILMKLVGEYASSYR-------TEHSALQTICTEQRGFFKQLFLN--PGYYENPVEL---- --------- >A_aegypti_AAEL003444-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MDTTDE--LDVL GF---------------------------------------------------------- ----------------------------------GSRTNESSKSIKEA------------ ------------------------------------------------------------ -LVSRAALDEYYD--TTNKRRGIALVFCHMNFSV--------------MAKRNGA-DKDR DDI-CNTLYGLDFDVRVFDDLSRKEVLDRLKDVSRE-D-HSDNDCLVVVMMSHGEQ---- ---G-VLYARDN-KYNVDSLWKNFVGNACPSLIGKPKMFFIQ--ACRGEQF-DEGVAYAA -----------KSPKDMVD---------SRQ-----------EQVLYSIP-----AMADL LVMYSTYD--GYYSWRNPRQGSWFIQSLCTELDENGR-V------RDLL----------- TLLTGVSRRTAYEFQSFVPHNAKMDAMKQIPCIVSMLTKTFYFT--KKTRSRVVTDID-- --------- >D_rerio_ENSDARP00000041413 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MALIFNQKQFDWK-----------LGLKTRNGT-DKDR DDLVSRRFQELNFEVKAYNDYSRDDVLLKIQEASAA-D-HVDADCFVCIFLSHGED---- ---G-HVYANDK-KIEIPEITDLFKGDKCRSLVGKPKIFIWQKQACRGDKL-DDAVTEM- --SVEDV--------EMAV---------D-------------AGVLYTLP-----AGADF IMCYSTAE--GFCSFREPLNGSWYIQDLCEILGRYHS-E------LQFT----------- DILTLVNMKVSLRSVPNCRN-RAAIGKKQMPCFASMLTKRLFFR--DN---TQIQ----- --------- >A_gambiae_AGAP009832-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QPLTKAFSAMFSRKQ-----EDS--SDTR GMPHGSPI---------------------------------------------------- ----------------------------------ASGSQTANGIIRP------------- ------------------------------------------------------------ -AYVIERYAAYYP--MNHKRRGMALIFSHNKYNVR----------NVSLPVREGS-AIDC KRL-KETLELFRFDVKVYPDFKLEEIKSVIGKVSSM-D-HSDSDCFLVAILTHGED---- ---GGIVYAYDQ-PYELSLIWSFFTADNCPSLAGRPKIFVVQ--ACRGNQL-DHGVKVQK ----------------------------D-------------GVARYSIP-----THADF LFAYATIP--GFMAFRNTTEGSWFINELCKELQENGH-R------YDIN----------- TLLTFVTQKVAYDHESVSNM-PEYNMRKQTPCVVSMLTRLLLFN--VV------------ --------- >O_latipes_ENSORLP00000014046 ------------------------------------------------------------ MDRRTLSRIDDELNSEEVAELCFLCTD--FIPRKRLEGISSAKDLFLKLEDATLL----- -----------DSSYLTQLFRTIHREDLVRQVQNGSRQAEEADA---------------- -----------------------------------------VPSLSDY------------ --------------------------------------------------------RVML YSIHDDMTEENLDKLKFLLNPKL--------NRRPLEKSKT--ALDVFVEMEK------- --------SQ-LISKDDVSGLYKLLLE-FDKKLAAVVEKYMQDHRGALTDTSHY--QKRP SIPSLESL---------------------------------------------------- ----------------------------------SVSQPETWSET-EDPNNGVRSDAT-- ---------------------------------------------------------PCP DPPTSPDEEEYYS--FTHEPRGLCVIFNNKLFFPE-----------SNLGERGGT-EKDE KSL-NNLFHRFGFEVVVHNNLTADLIESEITKLGQR-N-FSHDDALVVCVLSHGDN---- ---G-CVYGIDGKKVQLRALTLPFTSYRAPSLIGKPKLFFIQ--ACQGTLD-QSGYLPGS ---------EVKGDAELEA---------DAS-----------SSTSNSVP-----NDADF LLGMATVA--ECKSFRNKYTGSIYIQELCRQLERAAESSKM----EDIL----------- GVLVHVNREVSKGVF---------LNKKQMPEPKYTLTKKVVLK--YMN----------- --------- >G_gallus_ENSGALP00000013571 ---------------------------------------------------------MSS DFRKLLFDISEALATEELAALKFLSLE--HVPVRKQEDTEEPKAFFEVLKEKGMIEV--- ----------EDLFFLKELLYRINRIDLLASHLGSSREEMERELQVPG------------ -----------------------------------------KAKVSAY------------ --------------------------------------------------------RQLL YGIAEDLTPDDVRSIKFLLQEKL--------PKNKLQDNAS--MLKVLVEMER------- --------NG-IIKEDDLTMLKSILKA-FRADLKKKIDNYEEKTKGWPWKSSCF--PNKT QALSIS------------------------------------------------------ ----------------------------------ENLAVSSLIDNKESQESQSEWYSA-- ---------------------------------------------------------GIF PPHVQILLVESYK--MENNPHGYCVILNNYRFKNP-------------NETRKGT-VEDG KAL-KRVFKWLQFDTIEYMDLEAKQIFAKVNEYSKK-D-HSNMDCFVCFILSHGEK---- ---G-KIKGVDNELVNIKDLLSCFSGSNCPSLAGKPKLFFIQ--ACQGSVG-HPAVTVKE --DC---------SGHLET---------D-------------AIPALSIP-----DQADV LVGMATVE--DFECYRSIETGSVYIQCLCDKMELLCPLR------KDLI----------- TILTEVNKEVGRRVL---------NGWKQMPKITSTLRKQFIF---QI---PQCQ----- --------- >O_anatinus_ENSOANP00000001054 ------------------------------------------------------------ ---XLLFSIGEELAADDLEALKFLCLD--LIPLKKQETIQDALGLFRLLQEKGMLEE--- ----------GKLSFLKELLFRIHRIDLLKAHLGTSHGDVERELEEPG------------ -----------------------------------------RAQVSAY------------ --------------------------------------------------------RITT ETITGGSNKGIIKXFFFFSSQRE--------KKMRSDAVST--ALGIFIHMEK------- --------HG-KMNEGDLGMLKKILKD-VQPSLLIPIEEYEEKSRGFCVSQSRS--SWKL KHCL-------------------------------------------------------- ----------------------------------GTTLPHHSYRNYNQQVSSPKAAEE-- ------------------------------------------------------------ -MERISQIMAPYK--MNHLPHGFCVIINNSEFQNP-------------QNTRRGA-DKDA AAL-DKVFSWLQFKVEHHNNLKGEAISRVLRAYSER-D-HTDQDCFICCLLSHGQK---- ---G-EILGTDWEPVPLRALLGLFTSSACRTLATKPKIFFVQ--ACQGGQG-QGGLSLRG -----------REGALLEA---------D-------------AVVIPSVP-----DWADL LVGMATVE--DFICFRRPRHGSEYIQALCRALETFCPRRG-----KDLL----------- TILTHVNKEVGQKVF---------GSNKQMPEVKFTLQCPLIF---PV---P-------- --------- >D_rerio_ENSDARP00000072390 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------AFEPY--KKHKNIGKCLIISNEHFPVQ-----------FSLNRKKGN-SVDE RRL-SSTFKSLGFHVKVENNLSANQMIDALRTVSEE-D-HTDNSCFVCVLMSHGEE---- ---G-TILGSDERWIPVKTLTSLLTSDLCPSLRDKPKIFFLQ--ACRGVEY-DPGVEADS --------------VEASE---------D-------------FFGISDVP------ELDF LCCYSTVE--GYFAWRNPETGSIFIRELCKTLMDC---R------LEII----------- QILTRVNHLVAYYFQSYTLE-LETNRKRQMPCFASRLTKDFYLH--V------------- --------- >T_nigroviridis_ENSTNIP00000013855 ------------------------------------------------------------ ----------------------------------------------MEERHKKILQR--- ----------NRINLVSELE---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PLNLYDGLIE------- --------KG-VFTHDMIDEIKCSGAR--RDQARQLVRDLETRGSRAFPAFLEC--LKET GYHSLAELLQNGAPTVQIQPPTP----------------------------IPVDRPVIQ PLPISPPLV--------------PP-------EEPVSPVPKPSTPGRASPEVEYVTLK-- ------------------------------------------------------------ -GRIRRDSLQSYR--MEANPLGHCLIINNVEFEPK-----------SGLSNRNGS-NVDC DRL-ERRFKALNFTVKVKTNLKQRQIRQELSALSKV-D-HSQYDCCVVVILSHGTEVSHS RFPG-AVYGVDGQFVPVQHIATYLNGQYCPSLQGKPKLFFIQ--ACGGDEK-DTGFQVSP --DEFEPPVVGADDQTDAIPVSSSSDSLSMSDE---------PDARASLP-----TSSDI LVSYSTFP--GYVSWRDPKAGSWYVETLDRVLEENAA-L------HDLV----------- VMLTMVNDEVSQNQA--------KGLYKQMPGSFNFLRKRLYFI--AQ---P-------- --------- >B_taurus_ENSBTAP00000021099 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MENTENS--VDSK SIKTS------------------------------------------------------- ----------------------------------ETKILHGSKSMD-------------- ------------------------------------------------------------ ---SGISLEESYK--MDYPEMGLCIIINNKNFHEN-----------TGMCRRSPT-DDSV AQX-RETFMNLKYEVRIKNDLTCKEMLELMSNVSKE-D-HSKRSSFICVLLSHGEE---- ---G-IIFGTNG-PVNLKKLASFFRGDYCRSLTGKPKLFIIQ--ACRGTEL-DCGIETDS ---------GAE----------------D-------------DMACQKIP-----VEADF LYAYSTAP--GYFSWRNAKNGSWFIQALCEMLKKHAH-R------LELM----------- HILTRVNRKVAIEYESFSTD-SAFHAKKQIPCIMSMLTKELYF----------------- --------- >A_carolinensis_ENSACAP00000006831 ------------------------------------------------------------ --------------------------------------SRMLGVCGMQKCHQEALKK--- ----------NRVSLAKQLV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LKELMEHLIE------- --------KD-VITEEMMEMIQAKAGN--FSQNIEFLNLLPKRGPKAFSAFCEA--LRET KQPHLEEMLLLNLIDFLLF--------------------------------HHVIVPPQN AHLPLHTVCDL----------------LPFAYQLFISSAEPMEHSLDDGDGPHYPQVM-- ---------------------------------------------------------PCT PEFYRTHEQLAYK--LKSQPRGLALILSNIHFNKE-----------TDLDFRSGG-DVDN TAL-HMLFKHLGYQVVVRQDRTAQEMKEELEIFSKHPA-HRNVDSCIVSLLSHGIE---- ---G-GIYGIDGKLLQLQEIFRLFDNANCPNLQNKPKMFFVQ--ACRGDET-DHGVDQI- --DGNDRASSPGCEETDA----------NKK-----------ENPKLRLP-----TCSDM ICGYACLK--GTAAMRNTKHGSWYVEALTSVFAEDSG-H------MHVA----------- DMLVKVNRLIKLREGHAPG--TEFHRCKEMSEYCSTLCQDLYLF--PG---YFPG----- --------- >C_elegans_Y73B6BL.7 -------MKIGWLLITICSGIITKCINAHSSPYQNANESAIDDAYFLVLIIPAVSVAIVL VVVIFLCCPRQQIRSDNVIKLEEGVNDVIEENVTHVVSLREAKVSGMMTDLTRFRQEIFT KHLTFNSNPESIDAATKNVQNVKQSLDTWRDRIKERLDEIDRLCTEEGDSLTPEQYSALR EMRRQLADEYDTVLRTVEGIHTRLNILSALLIEFSSVTSSMQSWMTDRARLAGDIRHKSG DPMRVDEARFEAKSLMDEVVREESRLKTIGASVLKIEQEISAMRDDVRASRSTDDVGISM DEVYEKRRRVEVDYMQLLRQCQDLISLQIRLHAMNDEHAEQARRAEGWLQMLKNDVAGVA KDPRFKKDEDLIERDEELNRMAAGGSGGPTSRQLAMREKIEQREREEEEWRRKA--KEKF EEEAAKNRARERKWAEEHGFNRP-------------IRTRSQKYAEQDRIRYARKKAALE QSNEQSNESTDDAVESDSDDVPAPQSPPTPSPADPGPTTSSSSLTQDPASNATGFSDVPA PQAPPTPSPADPGPTTSSSSLTQDPASNATGFSGSSPPNSFEE---------TRMMCEDA SDGKKIDETRKYR--NNRSSKCRAIIINNVVFC--------------GMEKRIGS-DKDK KKL-SKLFERLGYQSTSYDNLKSSEILETVRQFTQS-N-HG--DSLIITIMSHGDQ---- ---G-LLYGVDGVPVQMLDIIDLMC---TASLAKKPKWLMCV--CCRGDRI-DRAVRCDG FIDNFFDRFPKFFQFMKSK-----------------------FPSHQTSS-----SQADL LVSFSTSP--GFLSFRDETKGTWYIQELYRVIIENAK-D------THLA----------- DLLMETNRRVVEKYEAD----KVVIVCKQAPEFWSRFTKQLFF---DV------------ --------- >M_musculus_ENSMUSP00000030747 ------------------------------------------------------------ ----------------------------------------------MDEADRQLLRR--- ----------CRVRLVSELQ---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VAELWDALLS------- --------RE-LFTRDMIEDIQQAGSGSRRDQARQLVTDLETRGRQALPLFISC--LEDT GQGTLASLLQSGRQAAKQDPEAV------------------KPLDHLVPVVLGPMGLTAK EQRVVKLDPSQPAVGNLTPVVLGPEELWPARLKPEVLRPETPRPVDIGSGGAHDVCVP-- ------------------------------------------------------------ -GKIRGHADMAYT--LDSDPCGHCLIINNVNFCPS-----------SGLGTRTGS-NLDR DKL-EHRFRWLRFMVEVKNDLTAKKMVTALMEMAHR-N-HRALDCFVVVILSHGCQASHL QFPG-AVYGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQ--ACGGEQK-DHGFEVAC --TSSQGRTLDSDSEPDAVPYQEGPRPLDQ------------LDAVSSLP-----TPSDI LVSYSTFP--GFVSWRDKKSGSWYIETLDGILEQWAR-S------EDLQ----------- SLLLRVANAVSAK-----------GTYKQIPGCFNFLRKKLFFK--TS------------ --------- >P_pygmaeus_ENSPPYP00000002138 ------------------------------------------------------------ ----------------------------------------------MDEADRRLLWR--- ----------CRLRLVEELQ---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VDQLWDALLS------- --------RE-LFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISC--LEDT GQDMLASFLRTNRQAAKL------------------------------------------ ---------SKPTLENLTPVVLRPEIVRPEIRKPEVLRPETPRPVDIGSGGFGDVGAL-- ------------------------------------------------------------ -ESMRGNADLAYI--LSMDPCGHCLIINNVNFCRE-----------SGLRTRTGS-NIDS EKL-RRRFSSLHFMVEVKGDLTAKEMVLALLELAQQ-D-HGALDCCVVVILSHGCQASHL QFPG-AVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQ--ACGGEQK-DHGFEVAS --TSPEDESPGSNPEPDATPFQEGLRTFDQ------------LDAISSLP-----TPSDI FVSYSTFP--GFVSWRDPKSGSWYVETLDDIFEQWAH-S------EDLQ----------- SLLLRVANAVSVK-----------GIYKQMPGCFNFLRKKLFFK--TS------------ --------- >T_guttata_ENSTGUP00000011206 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KK-------------------------------------------- ----------------------------------KNGEEEQPKPSLSN------------ ------------------------------------------------------------ -QYRIVTPTFQYN--MDYKKVGKCIIINNKNFEDK-----------TGMGTRNGT-DKDA GDL-AKSFKNLGFEVDIHHDRSRDDMEKLLKKAAEE-N-HSDAACFACILLSHGEE---- ---G-LIYGTDG-PMAIKSLTALFRGDKCKSLIGKPKLFFIQ--ACRGSEF-DEGIQTDS ---------GPAN-DTLET---------D-------------ANPRYKIP-----VEADF LFAYSTVP--GYYSWRNPGRGSWFVQSLCSVLNEHGK-Q------LEIM----------- QILTRVNYVVATNFESQSDD-PRFSEKKQIPCVVSMLTKELYF----------------- --------- >D_melanogaster_FBpp0082755 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MDDTDFSLFGQKNKHKKDK--ADAT KIAHT------------------------------------------------------- ----------------------------------PTSELDLKRIIISRPTN--------- ------------------------------------------------------------ --------EDTYE---NCARAGIALILNHKDVK--------------GQKQRVGT-ERDR DDM-EATLQGFGFDVRTFDDLTFSEINDTLKEVARE-D-HSQNDCFVLAVMSHGTE---- ---G-KVYAKDM-SYPVERLWNPFLGDNCKTLKNKPKLFFIQ--ACRGANL-EKAVEFSS ---------FAVMTRELVP---------EPAAAV--------QPITYAIP-----STADI LVFYSTFD--KFFSFRNVDDGSWFIQSLCRVLDQAAANEAATPEGVELL----------- RLLTAVNRKVAYEYQSNTKN-EALNQMKEMPNFMSTLTKTFQLR--VK---PKT------ --------- >O_anatinus_ENSOANP00000002508 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MADDQAPTMHQKE--CDFEDE--VDAK PERLKVAQLFS--KKK-------------------------------------------- ----------------------------------NEAESQSGGPLPVR------------ ------------------------------------------------------------ -N-RVVSSSFIYN--MKYENLGKCIIINNKNFASK-----------TGMSTRNGT-DKDA GNL-QKCFRSLGFDVSVFNDFSCNQMKEILQKASEE-N-HENSACFACILLSHGEG---- ---D-CIYGTDD-FIPIKELTILFRGDKCKSLLGKPKLFFIQ--SCRGTEF-DDGIQTDS ---------TPVT-D---S---------D-------------ANPGCRIP-----VEADF LFAYSTVPVKGYYSWRNVDRGSWFVQALCSVLHEHGK-E------LEIM----------- QLLTRVNHQVAINFESQASD-PRYCQKKQIPCLVSMLTKELYF----------------- --------- >G_aculeatus_ENSGACP00000013740 ------------------------------------------------------------ --------------------------------------------CGMQERDRLALRT--- ----------RSTVLCKQLV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VDELLIQSLQ------- --------TDEILTEAMAENIMAEQTS--QKRSWRLLLLLPKRGPRAFSSFCSA--LQET EQQHLYELLIQSSEKDGKET-----------------------------PGMLMCGQFID SSLPLPTQEVV-------------------AAKRARTQAESMEFSLD-ADSPINSPVL-- ---------------------------------------------------------PCT PDFYLSHCHQSYR--MNSSPRGFALVISNVTFDPC---------AAPDLDPRKGG-EVDD EVL-RKVFTELDYVVKVHRDLTAQDMRTCIEEFSRRPD-HRTMASCVVCLLSHGVE---- ---G-AIYGTDGQLLKLDWVFESFDNAHCPLLQNKPKMFFIQ--ACRGEEM-DCGVEQI- --DGPVRTCSPSCEQRDA----------GREGQGDASARQRGDMGRIKLP-----QRSDM ICGFASLK--GTAAMRNTKRGSWFVQELNKRLRLHAR-D------THLA----------- DIMVQVNRHIKEREGYAPG--TAHHRCKEMSEFTSSLCKDLYLF--PK---YQPQ----- --------- >T_rubripes_ENSTRUP00000045375 ------------------------------------------------------------ ----------------------------------------------MEERHKKILQR--- ----------NRTNLVGELD---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PSSLYDGLIE------- --------KR-VFTHDMIDEIKSSGTR--RDQARQLIRDLETRGSRAFPLFLEC--LQET GHHTLVELLQDGGPAVQIQPPTP----------------------------VPIDRPVIQ PLPVCKSAIRSRVLRGTMTVKAAPPVDVVRRDKAPVIPVPQPSTAPSPSPEREYMRLK-- -----------------------------------------------------------P QGRIRRDSIQSYK--MDANPSGHCLIINNVDFEPR-----------SELNDRKGS-NTDC DRL-ESRFKALNFIVKVKTNLKQRQIKHELSALSKM-D-HSQYDCCVVVLLSHGTEVSHS RFPG-AVYGVDGQFVPVQHITTYLNGQHCPSLQGKPKLFFIQ--ACGGDEK-DTGFEVSP --DEFEPPVVSAHDQTDAIPMSSSSDSLSMSDE---------PDARASLP-----TPSDI LVSYSTFP--GYVSWRDTQSGSWYIETLDRILEENAA-T------DDLV----------- TMLMMVNHEVSQNQA--------KGLYKQMPGSFNFLRKLLYFQ--S------------- --------- >M_domestica_ENSMODP00000001598 ------------------------------------------------------------ ---------------------------------------RMLGVWGMEQEHQEALKK--- ----------NRVVLAKQLL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSELLEHLLE------- --------KD-IITLEMRELIQAKVGS--FSQNVEFLNLLPKRGPHAFEAFCDA--LRET KQGHLEDLLHRTLYS--FQ------------------------------NLRPPLGCDYD SSFPLPVCDSC-----------------PPHKQLRLSV-ETMEHSLDNGDGPPSLQVK-- ---------------------------------------------------------PCT PEFYQTHQHLAYR--LQSRPRGLAMVLSNVHFNGE-----------KDLEFRSGG-DVDH SSL-VTLFKLLDYDVHVLRDQTAQKMQENLQRFAQLSA-HQSTDSCMVALLSHGIE---- ---G-GIYGVDGKLLQLQEVFRLFDNANCPNLQNKPKMFFIQ--ACRGDET-DRGVDLR- --DGKEHVASPGCEESDA----------GKE-----------KILKMRLP-----TRSDM ICGYACLK--GTAAMRNTKRGSWYIEALTQVFSERAR-D------MHVA----------- DML--VNALIKDREGYAPG--TEFHRSKEMSEYSSTLCRHLYLF--PG---HPPT----- --------- >R_norvegicus_ENSRNOP00000017972 ------------------------------------------------------------ ----------------------------------------------MEEADRQLLRR--- ----------CRVRLVRELQ---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VAELWDALLS------- --------RE-LFTRDMIEDIQRAGSGSRRDQARQLVIDLETRGRQALPRFISC--LEDT GQGSLASFLQSSGQAAKQDPEAV------------------TPLDHLVPVVLGPMGLKSK EQKVVKLDPSQPALGNLTPVVLGPEELWPTRLRPEVLTPETPRPVDIGSGRAHDVCTP-- ------------------------------------------------------------ -GKIERHADMAYT--LDSDPCGHCLIINNVNFCPS-----------SGLSTRIGS-HVDC EKL-QHRFCWLRFMVEVKNDLTAKKMVTALMEMAHR-D-HRALDCFVVVILSHGCQASHL QFPG-AVYGTDGCSVSIERIVNIFNGTGCPSLGGKPKLFFIQ--ACGGEQK-DHGFEVAF --TSSQDKAFDSDSEPDAVPYQEGPRTLDQ------------LDAVSSLP-----TPSDI LVSYSTFP--GFVSWRDKKSGSWYIETLDGVLEQWAR-S------EDLQ----------- SLLLRVANAVSEK-----------GVYKQIPGCFNFLRKKLFFK--LH------------ ---------