>D_melanogaster_FBpp0111838 --------MPAPPATVKPATGHTTKLNNGKSSNSNSNHTLSNSIAHLSDSRTNLTVNTPT TCQRLSEMFRRSIASSTQSSSRENTYEEWTKTLSFPSRLSPNRNSKDCSTLASPV-PPPT PPRNKTTSGSGNCATSRSSSSTVSSSHS-------S-S--HSSPTPGNNNNNM------- ---PIT-ELEQIIYPGPDP-KHIMGSLVFCIHHKQGCKWSDELRKLK------------- --------------------------------------GH--L-NACKHD-ATQCPN--- ---KCGAQIPRIMMTD----HLQYTCTMRRTRCEFCQSEFSGAGL-E--EHNGSCGQEPV YCEAKCGQRILRGRMTLHKSKDCAKRLRRCAHCQREFSADTLPLHAAQCPRAPLACPQ-- RCDA--GPIPRG-------ELEAHLRDECQSLA--------VSCSFKEAGCRFK---GPR QMLEAHLESNA---AAHLSLMV-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LSSRQGQQIQMLKSAVSK---------L-SINYTGTLLWKITDWS--AKMAEARGKDG-- LELVSPPFYTSQYGYKLQASMFLNGNGPGE-NTHVSVYIKVLPGEYDALLKWPFSHS--- ITFTLFEQG--AQSG--QGGVAESFVPD--PTWEN---FQRP----------S-NEP--D QL-GFGFPRFISHELLHSR---PFIKGDTVFL---RVKVD-PSKIV-------------- -----AV----------------------- >A_aegypti_AAEL006649-PA ------------------------------------------------------------ ---------------------MVRSLSQWTKTLSFPARISPNRNSKECSVNVLPITPPPA PPRNKSTTST----TSSASSSTSALSHS-------S-A--TSSPSP---PPNV------- ---PIT-EISQIIYPDPESEKAIMGSLVFCIHHKQGCKWSDELRKLK------------- --------------------------------------AH--L-NTCKHD-AIQCPN--- ---KCGSQIPRVMMTD----HLAFTCILRRAICEFCNVEFTGIGL-E--EHAGTCSSEPI YCESKCGTRVVRGRMSIHRAKDCAKRLRRCPHCSREFSADTLSAHGATCPRSPVPCPQ-- RCDA--GPFARA-------DLEGHLRDECKALS--------VPCTFKEAGCRFK---GPR HLLEAHLESNT---SSHLSLMV-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LSGRQGQQINMLKNAMAK---------L-STNYTGTLLWKITDWS--AKMVEAKSKDG-- LELVSPPFYTSQYGYKLQASMFLNGNGPGE-GTHVSVYIKVLPGEYDALLKWPFSHS--- VTFTLFEQGTLGS----QGGVAESFVPD--PSWEN---FQRP----------S-TEP--D AL-GFGFPRFVSHELLNRR---PFVREDTVFL---RVKVD-PSKIV-------------- -----AV----------------------- >A_gambiae_AGAP010017-PA ------------------------------------------------------------ ---------------------MVRSLSQWTKTLSFPARISPNRNSKDCNVNVLPITPPPA PPRNKST--S----TSSASTMSSSSSPS-------S-S--SSSPTP---PPNV------- ---PIT-EISQIIYPDPESEKAIMGSLVFCIHHKQGCKWSDELRKLK------------- --------------------------------------AH--L-NTCKHD-AIQCPN--- ---KCGSQIPRVMMTD----HLAFTCILRRAICEFCNVEFTGIGL-E--EHAGTCSSEPI YCESKCGTRVLRGRMSIHRAKDCAKRLRRCPHCGREFCADTLAAHGATCPRSPIPCPQ-- RCDA--GPFARA-------DLDAHLRDECKALT--------VPCTFKEAGCRFK---GPR HLLEAHLEANT---SAHLSLMV-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LSGRQGQQINMLKSAMAK---------L-STNYTGTLLWKITDWS--VKMQEAKTKDG-- LELVSPPFYTSQYGYKLQASMFLNGNGPGE-GTHVSVYIKVLPGEYDALLKWPFSHS--- VTFTLFEQGTLGSGGGGQGGVAESFVPD--PTWEN---FQRP----------S-TEP--D AL-GFGFPRFVSHELLNRR---PFVRDDTVFL---RVKVD-PSKIV-------------- -----AV----------------------- >X_tropicalis_ENSXETP00000056667 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------S-E--GVFKCP---EDQL------- ---PLD-YAK--IYPDRDLETQVMGLSIRCIHSEEGCRWSGQLKQLQ------------- --------------------------------------PH--L-NICAFN-VIPCPN--- ---RCSTKLIRRDLPE----HMQHDCPKRKVRCEFCGADFTGEAY-E--DHQGCCPQESV YCENKCGARMMRRVLSQHSLVECPKRTQPCPYCNKEFVFDTIQSHQYQCPRYPTPCPN-- QCGI--ASIARE-------DLSNHLKDSCSSAL--------VLCPFKDSGCKHR---GPK ITISRHLEENM---RAHLSMMS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S LVSRQRQEILELRKQVEE---------L-SVSSEGVLIWKISDYS--RKVQEAKVRGN-- FESFSPPFYTHKYGYKLQVSAFLNGNGSGE-GSYLSVYIRVLPGEYDNLLEWPFSYR--- VTFSLLDQSDPSLSK--PQHITETFNPD--PNWKN---FQKP-----TGSRNS-LDE--S TL-GFGYPKFISHEDIRKR---NYVRDNAIFL---RASVEIPQKII-------------- -----A------------------------ >M_musculus_ENSMUSP00000017530 ------------------------------------------------------------ ----------------MPGFD-YKFLEKPKRRLLCPLCGKPMREPVQVST---------- --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL------- ---PLD-YAK--IYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQ------------- --------------------------------------GH--L-NTCSFN-VVPCPN--- ---RCPAKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGVCPQESV YCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLPVPCPN-- QCGV--GTVARE-------DLPTHLKDSCSTAF--------VLCPFKESGCKHR---CPK LAMGRHVEESV---KPHLAMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LVSRQRQELQELRRELEE---------L-SIGSDGVLIWKIGSYG--RRLQEAKAKPN-- LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSIYIRVLPGAFDNLLEWPFARR--- VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--S SL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKIL-------------- -----S------------------------ >R_norvegicus_ENSRNOP00000018468 ------------------------------------------------------------ ----------------MPGFD-YKFLEKPKRRLLCPLCGKPMREPVQVST---------- --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL------- ---PLD-YAK--IYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQ------------- --------------------------------------GH--L-NTCSFN-VVPCPN--- ---RCPAKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGVCPQESV YCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLPVPCPN-- QCGV--GTVARE-------DLPTHLKDSCSTAF--------VLCPFKESGCKHR---CPK LAMGRHVEESV---KPHLAMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN-- LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSIYIRVLPGAFDNLLEWPFARR--- VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--S SL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKIL-------------- -----S------------------------ >P_troglodytes_ENSPTRP00000015252 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------L-------S-E--GVFKCP---EDQL------- ---PLD-YAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------------- --------------------------------------GH--L-NTCSFN-VIPCPN--- ---RCPMKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGMCPQESV YCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPN-- QCGV--GTVARE-------DLPGHLKDSCNTAL--------VLCPFKDSGCKHR---CPK LAMARHVEESV---KPHLAMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN-- LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--S SL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKIL-------------- -----S------------------------ >P_pygmaeus_ENSPPYP00000009119 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------E--GVFKCP---EDQL------- ---PLD-YAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------------- --------------------------------------GH--L-NTCSFN-VIPCPN--- ---RCPMKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGMCPQESV YCENKCGARMMRRLLAQHATSECPKRTQPCTYCSKEFVFDTIQSHQYQCPRLPVACPN-- QCGV--GTVARE-------DLPGHLKDSCNTAL--------VLCPFKDSGCKHR---CPK LAMARHVEESV---KPHLAMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN-- LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--S SL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKIL-------------- -----S------------------------ >H_sapiens_ENSP00000262395 ------------------------------------------------------------ ----------------MPGFD-YKFLEKPKRRLLCPLCGKPMREPVQVST---------- --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL------- ---PLD-YAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------------- --------------------------------------GH--L-NTCSFN-VIPCPN--- ---RCPMKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGMCPQESV YCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPN-- QCGV--GTVARE-------DLPGHLKDSCNTAL--------VLCPFKDSGCKHR---CPK LAMARHVEESV---KPHLAMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN-- LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--S SL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKIL-------------- -----S------------------------ >T_rubripes_ENSTRUP00000012878 ------------------------------------------------------------ ----------------MPGFD-YKFLEKPKRRFQCPLCSKAMREPVQVST---------- --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL------- ---PLD-YAK--IYPDPELEQQILALAIRCIHSEEGCRWTGQMKQLQ------------- --------------------------------------GH--F-STCAFN-VIPCPN--- ---RCSVKLTRRDLPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NHQGVCPQESV YCENKCGARMMRRLLSQHGMAECPKRTQPCKYCSKEFVFDTIQNHQYHCPRFPVQCPN-- QCGT--PNIARE-------DLANHVKDNCGSAL--------VLCPFKDAGCKHR---CPK LAIGRHLEDTT---KSHLTMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------N LVGRQRQEILELRREMEE---------L-SVGHDGILIWKLNDYS--RKLQEAKIRSN-- HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYIRVLPGEYDNLLEWPFSYK--- VTFSLLDQSDPSLSK--PQHITETFNPD--PNWKN---FQKP-----SSTRNS-LDE--S TL-GFGYPKFISHEEIKKR---NYVRDNCIFI---KASIEIPQKIM-------------- -----A------------------------ >B_taurus_ENSBTAP00000050075 ------------------------------------------------------------ ----------------MPGFD-YKFLEKPKRRLLCPLCGKPMREPVQVST---------- --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL------- ---PLD-YAK--IYPDPELEVQVLGLSIRCIHSEEGCRWNGPLRHLQ------------- --------------------------------------GH--L-NTCSFN-VVPCPN--- ---RCPAKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E--SHEGVCPQESV YCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPN-- QCGV--GTVARE-------DLPGHLKDSCSTAL--------VLCPFKDSGCKHR---CPK LAMARHVEESV---KPHLAMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN-- LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--S SL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKIL-------------- -----S------------------------ >B_taurus_ENSBTAP00000016271 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------Q--IYPDPELEVQVLGLSIRCIHSEEGCRWNGPLRHLQ------------- --------------------------------------GH--L-NTCSFN-VVPCPN--- ---RCPAKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E--SHEGVCPQESV YCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPN-- QCGV--GTVARE-------DLPGHLKDSCSTAL--------VLCPFKDSGCKHR---CPK LAMARHVEESV---KPHLAMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN-- LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--S SL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKIL-------------- -----S------------------------ >E_caballus_ENSECAP00000009502 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------S-E--GVFKCP---EDQL------- ---PLD-YAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------------- --------------------------------------GH--L-NTCSFN-VVPCPN--- ---RCPTKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E--SHEGMCPQESV YCENKCGARMMRRLLAQHATSECPKRTQPCTYCAKEFVFDTIQSHQYQCPRLPVPCPN-- QCGV--GTVARE-------DLPGHLKDSCSTAL--------VLCPFKDSGCKHR---CPK LAMARHVEESV---KPHLAMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN-- LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--S SL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKIL-------------- -----S------------------------ >M_mulatta_ENSMMUP00000028200 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------S-E--GVFKCP---EDQL------- ---PLD-YAK--IYPDPELEVQVLGLPIRCIHSEEGCRWNGPLRHLQ------------- --------------------------------------GH--L-NTCSFN-VVPCPN--- ---RCPMKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGMCPQESV YCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPN-- QCGV--GTVARE-------DLPGHLKDSCSTAL--------VLCPFKDSGCKHR---CPK LAMARHVEESV---KPHLAMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN-- LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--S SL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKIL-------------- -----S------------------------ >G_aculeatus_ENSGACP00000014759 ------------------------------------------------------------ ----------------MPGFD-YKFLEKPKRRFQCPLCSKAMREPVQVST---------- --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL------- ---PLD-YAK--IYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQ------------- --------------------------------------GH--F-STCAFN-VIPCPN--- ---RCSVKLTRRDLPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NHQGVCPQESV YCENKCGARMMRRLLSQHGLAECPKRTQPCKYCGKEFVFDTIQNHQYHCPRFPVQCPN-- QCGT--PNIARE-------DLANHVKDNCGSAL--------VLCPFKDAGCKHR---CPK LAIGRHLEDTT---KSHLTMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------N LVGRQRQEILELRREMEE---------L-SVSHDGVLIWKLSDYS--RKLQEAKLRSN-- HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYIRVLPGEYDSLLEWPFSYK--- VTFSILDQSDPSLSK--PQHITETFNPD--PNWKN---FQKP-----SSSRNS-LDE--S TL-GFGYPKFISHDEIKKR---NYIRDNCVFI---KASIEIPQKIM-------------- -----T------------------------ >O_latipes_ENSORLP00000005579 ------------------------------------------------------------ ----------------MPGFD-YKFLEKPKRRFQCPLCSKAMREPVQVST---------- --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL------- ---PLD-YAK--IYPDPELEQQILSLPIRCIHSEEGCRWTGQMKQLQ------------- --------------------------------------GH--F-STCAFN-VIPCPN--- ---RCSVKLTRRDLPD----HLQHDCPKRKVKCEFCGSEFTGEAF-E--NHQGVCPQESV YCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQFHCPRFPVQCPN-- QCGT--PNIARE-------DLANHVKDNCGSAL--------VLCPFKDAGCKHR---CPK LAIGRHLEDTT---KSHLTMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------N LVSRQRQEILELRREMEE---------L-SVSHDGVLIWKLNDYS--RKLQEAKLRSN-- HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYIRVLPGEYDNLLEWPFSYK--- VTFSILDQSDPSLSK--PQHITETFNPD--PNWKN---FQKP-----CSTRNS-LDE--S TL-GFGYPKFISHEEIKKR---NYIRDNCIFI---KASIEIPQKIM-------------- -----G------------------------ >M_domestica_ENSMODP00000024090 ------------------------------------------------------------ ----------------MPGFD-YKFLEKPKRRLLCPLCAKAMREPVQVST---------- --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL------- ---PLD-YAK--IYPDPELEAQVLSLPIRCIHSEEGCRWTGALRQLQ------------- --------------------------------------VH--L-SSCGYN-VVACPN--- ---RCNGKLSRRDLPS----HLQHECPKRRLKCDFCGIDFTGEAF-E--SHEGVCPQESV YCENKCGARMMRRLLGQHMMAECPKRTQPCAYCTKEFVYDTIQNHQHQCPRYPIPCPN-- QCGM--GSIPRE-------DLNSHLKENCSTVP--------VLCPFKDAGCKHR---CPK LAMGRHMEESV---KPHLAMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LVSRQRQELQELRRDVEE---------L-SVGCDGVLIWKIGGYG--RRLQEAKARAN-- HECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- VTFSLLDQSDPAVAK--PQHVTETFHPD--PHWKN---FQKP-----GTWRGS-MDE--S AL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RASVELPKKIL-------------- -----S------------------------ >D_rerio_ENSDARP00000013849 ------------------------------------------------------------ ----------------MPGFD-YKFLEKPKRRFQCPLCSKAMREPVQVST---------- --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL------- ---PLD-YAK--IYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQ------------- --------------------------------------SH--F-STCAFN-VIPCPN--- ---RCSVKLTRRDLPE----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NHQGICPQESV YCENKCGARMMRRLLSQHTMTECPKRTQPCKYCGKEFVYDTIQNHQYHCPRFPVQCPN-- QCGT--PNIARE-------DLANHVKESCGSAL--------VLCPFKEAGCKHR---CPK MAIGRHLEEST---KSHLTMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S LVGRQRQEILELRREMEE---------L-SVSHDGVLIWKLTDYS--RKLQEAKLRNN-- HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSIYIRVLPGEYDNLLEWPFSYK--- VTFSILDQSDPSLSK--PQHITETFNPD--PNWKN---FQKP-----CSSRNS-LDE--S TL-GFGYPKFISHEEIKKR---NYIRDNSIFL---KASIEIPQKIM-------------- -----A------------------------ >D_rerio_ENSDARP00000056877 ------------------------------------------------------------ ----------------MPGLD-LKFLERPRRKFYCPLCEKPMREPVQVST---------- --------------CGHRFCDTCLQEYL-------S-E--GVFTCP---EDQL------- ---PLD-YAK--IFPDLELEQQILSLPIRCIHSEEGCRWTAQNKLLQ------------- --------------------------------------AH--L-SVCEFN-VVSCPN--- ---RCSVKLLRRELPE----HLQHDCAKRKLHCDHCGEQFTGEAY-E--NHQGVCPEESV YCENKCGARMVRRLLAQHSVSECLKRKLPCRYCKKEFLYDTIQNHQQQCPRFPMQCPN-- RCGT--PGITRD-------TLMAHVKEGCSTAM--------VLCPFKEAGCKHR---SPK TGVARHLEEAA---PTHLSLLC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G LVNRQRLELRDLRRRMEE---------L-SGSRDGTLLWKLTDFS--QRLQEAKTRTSGC LELFSPAFYSHNYGYRLQVSAFLNGNGSGE-DTHMSVYLRVLPGEYDGLLEWPFPYR--- VSFSLLDQCDPALTK--PQHITETFSPD--PTWKN---FQRPRPGALGSIRGGCLDE--S ML-GFGYPKFISHEEMKKR---NYIRDNAVFI---KASIDVVQKIL-------------- -----N------------------------ >O_cuniculus_ENSOCUP00000000748 ------------------------------------------------------------ ----------------MPGFD-YKFLEKPKRRLLCPLCGKPMREPVKVST---------- --------------CGHRFCDTC-QSFL-------X-X--XXXXXX---XXXX------- ---XXX-XXX--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ------------- --------------------------------------GH--L-NTCSFN-VVACPN--- ---RCPAKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGMCPQESV YCENKCGSRMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPN-- QCGV--GTVARE-------DLPGHLKDSCSTAL--------VLCPFKDSGCKHR---CPK LAMARHVEESV---KPHLAMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN-- LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- VTFSLLDQSDSGWAR--PQHVTETFHAD--SNWEE--AFQKP-----GTWRGS-LDE--S SL-GF------------------------------------------------------- ------------------------------ >T_nigroviridis_ENSTNIP00000019321 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------VKLTRRDLPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E--NHQGVCPQESV YCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQYHCPRFPVQCPN-- QCGT--PNIARE-------DLANHVKDNCGSAL--------VLCPFKDAGCKHR---CPK LAIGRHLEDTT---KSHLTMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------N LVGRQRQEILELRREMEE---------L-SVSHDGILIWKLNDYS--RKLQEAKIRSN-- HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYIRVLPGEYDNLLEWPFSYK--- VTFSLLDQSDPSLSK--PQHITETFNPD--PNWKN---FQKP-----NSTRNS-LDE--S TL-GFGYPKFISHEEIKKR---NYIRDNCIFI---KASIEIPQKIM-------------- -----A------------------------ >G_gorilla_ENSGGOP00000016344 ------------------------------------------------------------ ----------------MPGFD-YKFLEKPKRRLLCPLCGKPMREPVXXPP---------- --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL------- ---PLD-YAK--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------------- --------------------------------------XX--X-XXXXXX-XXXXXX--- ---RCPMKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E--SHEGMCPQESV YCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPN-- QCGV--GTVARE-------DLPGHLKDSCNTAL--------VLCPFKDSGCKHR---CPK LAMARHVEESV---KPHLAMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LVSRQRQELQELRRELEE---------L-SVGSDGVLIWKIGSYG--RRLQEAKAKPN-- LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYIRVLPGAFDNLLEWPFARR--- VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--S SL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RAAVELPRKIL-------------- -----S------------------------ >C_intestinalis_ENSCINP00000008928 ------------------------------------------------------------ ----------------MPGYQ-NKFVDKVRKRHQCPLCHFPMRDPVQITA---------- --------------CRHRYCDTCLQKFL-------G-E--GVFNCP---VDHL------- ---SLD-YAK--IYPDPDLETEIMSLTTHCTNYSSGCKWTGKLHNLK------------- --------------------------------------AH--M-DKCSHS-ERDCPN--- ---RCGVRIRSMKLAD----HLEYECMKRRVACDFCGKEFTGEMM-D--EHEGACPQESV HCENKCGAKMLRKYLSRHVTGDCPKRPTKCTHCSKDFNIDILQTHHGTCPRYPIGCPN-- RCDV--LKIPRE-------ELEIHLKEHCKSAL--------TACPFKEAGCKHK---CPR YHLERHLTEAN---ASHIRAMF-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------D LVKTQRSHISELQKQLSD---------L-TVNTNGTLLWKIPGYS--QKLQAAQKDQA-- IEMRSPPFYTHRYGYKLQLSAFLNGNGSGL-NSHMSLY---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ >C_familiaris_ENSCAFP00000027741 ------------------------------------------------------------ ----------------MPGFD-YKFLEKPKRRLLCPLCGKPMREPVQVST---------- --------------CGHRFCDTCLQEFL-------S-E--GVFKCP---EDQL------- ---PLD-YAK--IYPDPELEVQVLSLAIRCIHSEEGCRWSGPLRHLQ------------- --------------------------------------SH--L-NTCSFN-VIPCPN--- ---RCPTKLSRRDLPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E--SHEGVCPQESV YCENKCGARMMRRLLAQHAASECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPN-- QCGV--GTVARE-------DLPGHLKESCSTAL--------VLCPFKDSGCNTG---CPA FPLAPLVPEASYADQAHGGSCC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E AATGLLSALYLPRSELGT---------C-SSPREPPWAWSAYEASGTKGANGKEEDQN-- IRA-----FVSCYGYII----ILENPITPI-NHHSSLYIRVLPGAFDNLLEWPFARR--- VTFSLLDQSDPGLAK--PQHVTETFHPD--PNWKN---FQKP-----GTWRGS-LDE--S SL-GFGYPKFISHQDIRKR---NYVRDDAVFI---RASVELPRKIL-------------- -----S------------------------ >O_anatinus_ENSOANP00000019424 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PCPYCTKEFVFDTIQNHQYQCPRFPLPCPN-- QCGT--GAVARE-------DLPGHLKENCNTAP--------VLCPFKDAGCKHR---CPK LAMSRHLEDSV---KLHLGLTW-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LVSRQRQELQELRRDVEE---------L-AAGSDGVLVWRIGGYG--RRLQEARGRPN-- HECLSRPFYTHKYGYRLQVSAFLNGNGSGE-GTHLSLYIRVLPGDYDNLLEWPFALR--- VTFSLLDQSDPSLSK--PQHVTETFHPD--PHWKN---FQKP-----GAWRGS-GSS-GA AL-GFGYPKFISHEDIRKR---DYVRDDAVFI---RAAVELPRRIL-------------- -----A------------------------ >C_intestinalis_ENSCINP00000003738 ------------------------------------------------------------ ----------------------------------CVECKYTLEFPVALSN---------- --------------CEHHACSQCVSRLW-----------KISRSCP---LDGK------- ---VID-RNE--VTIDEKLQIELNNLNMVCPYKHCGCHWEGMFFDFK------------- --------------------------------------SH--Y-DECLYT-EEVCSN--- ---DCGFRCSKHLMDN----HLQIECSKRLVVCEFCALHLKAENE-I--EHL-------- ----------------------------------------------KSCIRFPVTCPK-- KCGT--KEIPRE-------ELNAHLELDCQLAD--------KVCPYETVGCTFT---CSR EKMATHVDECF---RKHVSLLC--DGFRKQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AE LLGLQKKQLFEHKQILHDHGKMVRNGIFSNIEFDSQLLWKISEWS--SKKIEAEAGKR-- TVLQSPLFYSARFQYKLAVLLLPNGDGKAK-GTHLSIYVRLCKGEYDALLSWPYRLP--- IEISLIDQSQDPRA---RINHTYSLRPN--PCKENKPFLGRP------------TSE--S NP-SFGSQTFMPLDTLNTR---DYIRDDAIFI---RVSVLHDET---------------- ------------------------------ >M_mulatta_ENSMMUP00000022296 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------CPNGL YCSV--GTVAQE-------DLP-HLKDSCSTAL--------VLCSFKDSSCKHR---CPK WAMAWHVEESV---KPHLVMMC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A LLIWQWQELQDLQQELED---------L-SVGSDGVLIWKTGSCG--QWLQEAKAKPN-- LECFSPAFYTQKCGYKLQVSAFLNDKGSGE-GTRLSLYIDLLPGAFDNLLEWSFAPC--- VTFCLLDQSDPGLAK--PQHITDTFHPG--PNWKN---FQKP-----GTWEGS-LDE--S SL-GFGYLKFISHQDIQKR---KSYSQNCVFVTWGKCFSILKKKFL-------------- -----S------------------------ >T_nigroviridis_ENSTNIP00000005138 -------------------PAGG------------------------------------- ----------PAGFQPLHGGFRDHFVEAPEAKYCCESCRLVLCQPRQTE----------- --------------CGHRFCQSCITQLL-------G-H--ANPVCP---ADME------- ---PLF-KDK--IFRDVCCHREIMALKVYCRSEANGCQEQMRLQQIP------------- --------------------------------------DH--L-NVCPFF-EVPCPLG-- ---KCKERMMRKEIPD----HLSWKCKFRESSCEFCMTKMPLTEL-Q--KHK-------- ---------------------------------------------ETVCPAFPVSCPN-- HCSF--SSLPRS-------ELSNHQH-ECPKAQ--------VSCQFHGYGCTFK---GLN QLMRQHESTSA---AEHLRMMA--KRNSMLEGKLDDVKGEL-LERLKHLPVVSSRVSE-- ---------------------------LENA---SDELR-------EKNRQMEQKLATMQ KLMSSHSEKLLEVELEL-----------RALRGL---RD---EVENLRGSLEGFRTRLS- ALEQGGRGGSGS-THTLASLEAQ--------------------------MNRH-----DD MLSVHDIRLADMDLRFQV---------LETASYNGTLIWKIRDYK--RRKQEAVAAKT-- LSLYSQPFYTGYFGYKMCARIYLNGDGMGK-GTHLSLFFVVMRGEYDALLPWPFKQK--- VTLMLMDQGPL------KKHLGDAFKPD--PNSSS---FRRP------------VVE--M NI-ASGCPLFVSQSVLETG---SYIKDDTIFI---KVTVD-TSDLP-------------- -----EP----------------------- >T_rubripes_ENSTRUP00000013348 -------------------MSAGRSTDGREVQIPLQQAAPSLAMPLSVA----------- --PLLTSHCVPAGFLPLHGGFRDHFVEALEAKYCCESCRLVLCQPRQTE----------- --------------CGHRFCQSCINDIL-------S-H--PNPVCP---ADTE------- ---PLF-KDK--VFRDVCCHREIMALKVYCRSEANGCQEQMRLQQIP------------- --------------------------------------DH--L-NTCPFF-EVPCPLG-- ---KCKERMMRKEIPE----HLSWKCKYRETSCEFCMTKMPLTEL-Q--KHK-------- ---------------------------------------------ETVCPAFPVSCPN-- HCSL--SSLPRS-------ELSSHQH-ECPKAQ--------VSCPFHGYGCTFK---GLN QVMRQHESSSA---AEHLRMMA--KRNSALESKLDDVKGEL-LERFKVLPVLSSRVAE-- ---------------------------LESS---NDELR-------EKNRQTEQKLGTMQ KLMSSHSEKLLELELEL-----------RSLRGL---RD---EVENLRGTLESVRTRLN- ALEQGGRSGSGS-THTLASLEAQ--------------------------MNRH-----DD MLSVHDIRLADMDLRFQV---------LETASYNGTLIWKIRDYK--RRKQEAVAAKT-- LSLYSQPFYTGYFGYKMCARIYLNGDGMGK-GTHLSLFFVVMRGEYDALLPWPFKQK--- VTLMLMDQGPL------KKHLGDAFKPD--PNSSS---FRRP------------VVE--M NI-ASGCPLFVSQSVLETG---SYIKDDTIFI---KVTVD-TSDLP-------------- -----EP----------------------- >G_aculeatus_ENSGACP00000005703 ---------------------------GGRCRFPLQQVAPSLTPALSVASP--V---HRQ VNPWPPSDTTPQRFLPLHKGFRDHFALTPEAKYCCETCSLVLCQPRQTE----------- --------------CGHRFCQSCINDIL-------S-H--PNPVCP---ADME------- ---PLF-KDK--IFRDVCCHREIMALKVYCRSEANGCQEQMSLQQIP------------- --------------------------------------DH--L-NVCPFF-EVPCPLG-- ---KCKERMMRKEIPD----HLSWKCKHRETSCEFCMTKMPLTDL-Q--KHK-------- ---------------------------------------------ETVCPAFPVSCPN-- HCSV--SSLPRS-------ELSSHQN-DCPKAQ--------VCCQFQRYGCTFQ---GLN QDMRQHESTSA---GEHLRMIA--NKNSVLENKVEDIKGEL-LERYKVLPALSSRLSE-- ---------------------------LENQ---SDELR-------EKNRQVEQKLATMQ KLMSSHSEKLLEVELEL-----------RSLRVL---RD---EVENLRGTLENVRTRLN- TLEQGGRSGTGSTTHTLATLENQ--------------------------LKRH-----DE MLSVHEIRLADMDLRFQV---------LETASYNGTLIWKIRDYK--RRKQEAVGAKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVVMRGEYDALLPWPFKQK--- VTLMLMDQGPL------RKHLGDAFKPD--PNSSS---FRRP------------AAE--M NI-ASGCPLFVSQSVLETG---TYIKDDTIFI---KVTVD-TSDLP-------------- -----DP----------------------- >B_taurus_ENSBTAP00000017918 -------------------MEPSKKL---DAAGALPANPPLKLHP--------------- -----ERGAGPAVLVPEQGGYKERFVKAVEDKYKCEKCRLVLCSPKQTE----------- --------------CGHRFCETCMGALL-------S-S--SSPKCT---ACQE------- ---VII-KDK--VFKDNCCKREILALQIFCRNEGRGCTEQLALGHLL------------- --------------------------------------VH--LKNDCQFE-ELPCVRA-- ---DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMVTL-Q--KHE-------- ---------------------------------------------DTECPCVAVSCPH-- KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >R_norvegicus_ENSRNOP00000010906 -------------------MEPSKKM---GAAGAAQPNPPLKLQP--------------- -----DRGA-ASVLVPEQGGYKEKFAKTVEDKYKCEKCRLVLCNPKQTE----------- --------------CGHRFCESCMAALL-------S-S--SSPKCT---ACQE------- ---SII-KDK--VFKDNCCKREILALQIYCRNEGRGCVEQLTLGHLL------------- --------------------------------------VH--LKNECQFE-ELPCLRA-- ---DCKEKVLRRDLRD----HVEKACKYREATCAHCKSQVPMITL-Q--KHE-------- ---------------------------------------------DTDCPCVVVSCPH-- KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >C_familiaris_ENSCAFP00000026713 -------------------MESSKKM---DSPGTLQTNPPLKLHP--------------- -----DRSAGTSIFVPEQGGYKERFVKTVEDKYKCEKCRLVLCNPKQTE----------- --------------CGHRFCETCMAAVL-------S-S--SSPKCT---ACQE------- ---SII-KDK--VFKDNCCKREILALQIYCRNEGGGCTEQLTLGHLL------------- --------------------------------------VH--LKNDCQFE-ELSCVRA-- ---DCKEKVLRRDLRD----HVEKACKYREATCPHCKSQVPMITL-Q--KHE-------- ---------------------------------------------DTECPCVVVSCPH-- KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >X_tropicalis_ENSXETP00000027864 -------------------MDTGKKT---DPSASV-----QKANP--------------- -----DRSLATTIYVPEQGGYKERFLKPVEEKYKCEKCRLVLCNPRQTE----------- --------------CGHRFCETCMNAIL-------S-S--TSPQCM---ACED------- ---NIT-KDK--VFKDNCCRREVLALQMFCRNETRGCKELITLGNLL------------- --------------------------------------IH--LKSDCQFE-ELSCPRA-- ---DCKEKVIRKDLSD----HIEKTCKYRETPCKFCRNQVPLVEM-Q--KHE-------- ---------------------------------------------DVDCPSVVISCPH-- MCSV--KSLLRS-------ELNAHLL-ECVNAP--------STCSFKRYGCTFK---GTN QQIKAHEASSA---VQHVNLMK--EWSNYLEAKVSMLQNES-SEKNKSIQILHNQMCS-- ---------------------------FEIE---IERHK-------EQLRNNEARIIQLQ RVIEGQADKLKDLDKEI-----------RNLRQT---GD---EADGMKSNYESLQNRLS- QLEVMAKNA--A-SWNPGVLETQ--------------------------INRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VSLMLMDQGPS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >D_rerio_ENSDARP00000038596 -------------------MSAGRNV---EQQIPLQQRPPSLAMP--------------- --SMAQRPRPEPGFSPLHGGFRDHFVTTPEPKYCCETCRLVLCNPRQTE----------- --------------CGHRFCESCINELL-------S-K--PNPVCP---ADLL------- ---PLF-EDK--IFRDVCCNREIMALKVYCRSEKNGCKEQMCLQQVM------------- --------------------------------------EH--L-VICPYF-EVPCPLG-- ---KCKEKMMRKDMPE----HLSRKCKHREVTCEFCSLKMALTEL-Q--KHK-------- ---------------------------------------------ETVCPAFPVACPN-- HCSF--SSILRS-------ELSSHQH-DCPKAQ--------VTCSFIRYGCSYK---GLN QEMREHESSFA---SEHLRMMA--VRNTTLEAKVEDVKSEL-MERYKVLPSLSSRLAE-- ---------------------------VERQ---YEEMR-------EKNRQLEQKLVSMQ MLMSSHSEKLLEVEMEL-----------RELRPLRAMRE---EVETLRGSVESMRSMVS- SLDSSCVNSASG-SHTLASLEQQ--------------------------LTRH-----DD LMSVHDVRLAEMDLKLQV---------LETASFNGTLIWKIRDYK--RRKQEAVVSKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVVMRGEYDALLQWPFKQK--- VTLMLMDQGPA------RKHLGDAFKPD--PSSSS---FRRP------------TGE--M NI-ASGCPLFVAQTVLENG---TYIKDDTIFI---KVTVD-TSDLP-------------- -----DP----------------------- >E_caballus_ENSECAP00000011833 -------------------MESSKKM---DSPGALQTNPPLKLHP--------------- -----DRSTSTAVFVPEQGGYKERFVKTVEDKYKCEKCRLVLCNPKQTE----------- --------------CGHRFCETCMAALL-------S-S--SSPKCT---ACQE------- ---GII-KDK--VFKDNCCKREILALQIYCRNESRGCVEQLTLGHLL------------- --------------------------------------VH--LKNDCQFE-ELACVRP-- ---DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMITL-Q--KHE-------- ---------------------------------------------DTECPCVVVSCPH-- KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCIFQ---GTN QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >M_domestica_ENSMODP00000016701 -------------------MDSSKKM---DPPNPLQTV-QQKANP--------------- -----DRGAAVSIYVPEQGGYKEKFVKPVEDKYKCEKCHLILCNPKQTE----------- --------------CGHRFCETCMHVLL-------S-A--PSPKCT---ACQE------- ---NII-KDK--VFKDNCCKREILALQIYCRNESRGCTEQLTLGHLL------------- --------------------------------------VH--LKSECQFE-ELPCVRA-- ---DCKEKILRKDLQD----HVEKSCKYREATCQYCKSQVPMITL-Q--KHE-------- ---------------------------------------------DTECPCVVVSCPH-- KCSV--QTLLRS-------ELNAHLS-ECINAP--------STCSFKRYGCTFQ---GTN QQIKTHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKSAGQA-ARNTGLLETQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >M_musculus_ENSMUSP00000021706 -------------------MESSKKM---DAAGTLQPNPPLKLQP--------------- -----DRGA-GSVLVPEQGGYKEKFVKTVEDKYKCEKCRLVLCNPKQTE----------- --------------CGHRFCESCMAALL-------S-S--SSPKCT---ACQE------- ---SII-KDK--VFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLL------------- --------------------------------------VH--LKNECQFE-ELPCLRA-- ---DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMIKL-Q--KHE-------- ---------------------------------------------DTDCPCVVVSCPH-- KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKSAGQA-ARNTGLLESQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >O_anatinus_ENSOANP00000023053 -------------------MDSSKKM---DPS-LVQQNVPPKGNP--------------- -----DRGPGASIYVPEQGGYKERFVKTVEDKYKCEKCHLILCNPKQTE----------- --------------CGHRFCETCMNMLL-------S-S--SSPKCS---ACQE------- ---NVI-KDK--VFKDNCCKREILALQIYCRNENRGCTEQLTLGHLL------------- --------------------------------------VH--LKSDCQFE-ELSCPRA-- ---DCKEKVLRKDLPD----HIEKSCKYREATCKYCTSQVPMITL-Q--KHE-------- ---------------------------------------------DTECPCVVVSCPH-- KCSV--QTLLRS-------ELNAHLS-ECINAP--------STCSFKRYGCTFQ---GTN QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKNAGQA-ARNTGMLETQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >T_guttata_ENSTGUP00000013203 -----------------------------------------RANP--------------- -----DRSPSASIYVPEQGGYKEKFVNAVEDKYKCEKCHLILCNPKQTE----------- --------------CGHRFCETCMNALL-------R-S--SSPKCT---ACQE------- ---SIV-KDK--VFKDNCCRRELLALQIYCRNENKGCKEQLSLGQLL------------- --------------------------------------MH--LRTDCQFE-ELPCPRA-- ---DCKEKILRKDLPD----HVEKTCKYRETTCKYCKSQVPMIML-Q--KHE-------- ---------------------------------------------DTECPCVMVSCPH-- KCSV--KTLMRS-------ELNAHLS-ECINAP--------STCSFKRYGCTFQ---GTN QQIKAHEASSA---VQHVNLLK--EWSNALENKVALLQNES-LEKNKSIQTLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKTAGQG-ARNTSLLETQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGPS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >G_gallus_ENSGALP00000036699 -----------------------------------------RANP--------------- -----DRSPSASIYVPEQGGYKEKFVNAVEDKYKCEKCHFILCNPKQTE----------- --------------CGHRFCETCMNALL-------S-T--PSPKCT---ACQE------- ---SIV-KDK--VFKDNCCRRELLALQIYCRNENKGCKEQLSLGQLL------------- --------------------------------------MH--LKTDCQFE-ELPCPRA-- ---DCKEKILRKDLPD----HVEKTCKYRETTCKYCKSQVPMIML-Q--KHE-------- ---------------------------------------------DTDCPCVMVSCPH-- KCSV--KTLMRS-------ELNAHLS-ECINAP--------STCSFKRYGCTFQ---GTN QQIKAHEASSA---VQHVNLLK--EWSNALENKVALLQNES-LEKNKSIQTLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKTAGQG-ARNTSMLETQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGPS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >A_carolinensis_ENSACAP00000000193 -------------------MDTSKKT---DPPVSVETV-QQKANV--------------- -----ERSPVPSVYIPEQGGYKEKFVNAVEDKYKCEKCRLILCNPRQTE----------- --------------CGHRYCETCMNALL-------S-C--TIPKCT---ACQE------- ---TIV-KEK--IFKDNCCRRELLALQIFCRNENKGCREQLTLGQLL------------- --------------------------------------TH--LRNDCLFE-ELPCPRV-- ---DCKEKILRKDLPD----HAEKTCKYRETTCKYCKSQVPIIMI-Q--KHE-------- ---------------------------------------------DADCPCVMVTCPH-- KCSV--SALLRK-------ELNAHLS-ECINAP--------STCSFKRYGCTFQ---GTN QQVKAHETSSA---VQHVDLLK--EWSNCLENKVAMLQNES-LEKNKSIQTLHNQICS-- ---------------------------FEIE---IERQK-------EMLRSNESKIHHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKTAGQG-ARNAGLLESQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGILIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGPS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >M_musculus_ENSMUSP00000082710 -------------------MAHSEEQA-AVPCAFI------------------------- -----RQNSGNSISLDFEPDTEYQFVEQLEERYKCAFCHSVLHNPHQTG----------- --------------CGHRFCQQCIRSLR-------ELN--SVPICP---VDKE------- ---VIK-PQE--VFKDNCCKREVLNLHVYCKN-APGCNARIILGRFQ------------- --------------------------------------DH--L-QHCSFQ-AVPCPNE-- ---SCREAMLRKDVKE----HLSAYCRFREEKCLYCKRDIVVTNL-Q--DHE-------- ---------------------------------------------ENSCPAYPVSCPN-- RCV---QTIPRA-------RVNEHLT-VCPEAE--------QDCPFKHYGCTVK---GKR GNLLEHERAAL---QDHMLLVL--EKNYQLEQRVSRIIEAL-SRKQTHSQRLPLTAPK-- ---------------------------KKKE---HPALR-------PICSVSGTLVSSGK -ALTSHTDKSAWLEAQV-----------RQLLQIVNQQPSRLDLRSLVDAVDSVKQRIT- QLEAS--------DQRLVLLEGE--------------------------TSKH-----DA HINIHKAQLNKNEERFKQ---------LEGACYSGKLIWKVTDYR--VKKREAVEGHT-- VSVFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMRGEFDSLLQWPFRQR--- VTLMLLDQSGK------KNHIVETFKAD--PNSSS---FKRP------------DGE--M NI-ASGCPRFVSHSTLENSKN-TYIKDDTLFL---KVAVD-LTDLE-------------- -----DL----------------------- >P_pygmaeus_ENSPPYP00000007003 -------------------MESSKKM---DSPGALQTNPPLKLHT--------------- -----DRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCRLVLCSPKQTE----------- --------------CGHRFCESCMAALL-------S-S--SSPKCT---ACQE------- ---SIV-KDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------------- --------------------------------------VH--LKNDCHFE-ELPCVRP-- ---DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KHE-------- ---------------------------------------------DTDCPCVVVSCPH-- KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >P_troglodytes_ENSPTRP00000011503 -------------------MESSKKM---DSPGALQTNPPLKLHT--------------- -----DRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTE----------- --------------CGHRFCESCMAALL-------S-S--SSPKCT---ACQE------- ---SIV-KDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------------- --------------------------------------VH--LKNDCHFE-ELPCVRP-- ---DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KHE-------- ---------------------------------------------DTDCPCVVVSCPH-- KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >H_sapiens_ENSP00000376500 -------------------MESSKKM---DSPGALQTNPPLKLHT--------------- -----DRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTE----------- --------------CGHRFCESCMAALL-------S-S--SSPKCT---ACQE------- ---SIV-KDK--VFKDNCCKREILALQIYCRNESRGCAEQLMLGHLL------------- --------------------------------------VH--LKNDCHFE-ELPCVRP-- ---DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KHE-------- ---------------------------------------------DTDCPCVVVSCPH-- KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >E_caballus_ENSECAP00000005414 -------------------MAYSEEQG-GVPCGFI------------------------- -----RQNSSNSVSLDFEPNTEYRFVEQLEERYKCAFCHSVLHNPHQTG----------- --------------CGHRFCQHCILSLR-------ELN--AVPLCP---VDKE------- ---VIK-SQE--VFKDNCCKREVLNLYVYCKN-APGCNAKIILGRYQ------------- --------------------------------------DH--L-QQCLFQ-AVQCSNE-- ---HCQESVLRKNLKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NHE-------- ---------------------------------------------ENMCPEYPVSCPN-- KCL---QIIPRT-------EVDEHLA-VCPEAE--------QDCPFKQYGCPVK---DKR GNLQEHEHSAL---RDHMLLVL--EKNLQLEKQISDLHRSL-ERKESKIQQLTETVNK-- ---------------------------FEKE---FKQFA-------QLFGKNGSFLSNIQ -LLASHLDKSAWLEAQV-----------RQLLQMANQQETKFDLRALMEAIDTVKQKIT- LLETH--------DQRIVVLEGE--------------------------TNKH-----DV HINIHKAQLNKNEERFKL---------LEGACYNGKLIWKVTDYK--MKKREALEGHT-- VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMRGEFDSLLQWPFRQR--- VTLMLLDQSGK------KNHIMETFKAD--PNSSS---FKRP------------DGE--M NI-ASGCPRFVAHSTLENAKN-TYIKDDTIFL---KVAVD-LTDLE-------------- -----DL----------------------- >P_troglodytes_ENSPTRP00000003288 -------------------MAYSEEHK-GMPCGFI------------------------- -----RQNSGNSISLDFEPNIEYQFVERLEERYKCAFCHSVLHNPHQTG----------- --------------CGHRFCQHCILSLR-------ELN--TVPICP---VDKE------- ---VIK-SQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------------- --------------------------------------DH--L-QQCLFQ-AVQCSNE-- ---KCREPVLRKDLKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NHE-------- ---------------------------------------------ENLCPEYPVFCPN-- NCA---KIILKT-------EVDEHLA-VCPEAE--------QDCPFKHYGCAVT---DKR RNLQEHEHSAL---REHMRLVL--EKNVQLEEQISDLHKSL-EQKESKIQQLAETIKK-- ---------------------------LEKE---FKQFA-------QLFGKNGSFLPNIQ -VFASHIDKSAWLEAQV-----------HQLLQMVNQQQNKFDLRPLMEAVDTVKQKIT- LLENN--------DQRLAVLEEE--------------------------TNKH-----DT HINIHKAQLSKNEERFKL---------LEGTCYNGKLIWKVTDYK--MKKREAVDGHT-- VSIFSQSFYTSRCGYRLCARAYLNGDGSGR-GTHLSLYFVVMRGEFDSLLQWPFRQR--- VTLMLLDQSGK------KN-IMETFKPD--PNSSS---FKRP------------DGE--M NI-ASGCPRFVAHSVLENAKN-AYIKDDTLFL---KVAVD-LTDLE-------------- -----DL----------------------- >P_pygmaeus_ENSPPYP00000000253 -------------------MAYSEEHK-GMPCGFI------------------------- -----RQNSGNSISLDFEPNIEYQFVERLEERYKCAFCHSVLHNPHQTG----------- --------------CGHRFCQHCILSLR-------ELN--TVPICP---VDKE------- ---VIK-SQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------------- --------------------------------------DH--L-QQCLFQ-AVQCSNE-- ---KCREPVLRKDLKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NHE-------- ---------------------------------------------ENLCPEYPVFCPN-- NCA---KIILKT-------EVDEHLA-VCPEAE--------QDCPFKHYGCAVT---DKR RNLQEHERSAL---REHMRLVL--EKNVQLEEQISDLHKSL-EQKESKIQQLAETIKK-- ---------------------------LEKE---FKQFA-------QLFGKNGSFLPNIQ -VFASHIDKSAWLEAQV-----------HQLLQMVNQQQNKFDLRPLMEAVDTVKQKIT- LLENN--------DQRLAVLEEE--------------------------TNKH-----DT HINIHKAQLSKNEERFKL---------LEGTCYNGKLIWKVTDYK--MKKREAVDGHT-- VSIFSQSFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMRGEFDSLLQWPFRQR--- VTLMLLDQSGK------KN-IMETFKPD--PNSSS---FKRP------------DGE--M NI-ASGCPRFVAHSVLENAKN-AYLKDDTLFL---KVAVD-LTDLE-------------- -----DL----------------------- >M_mulatta_ENSMMUP00000038268 -------------------MAYSEEHR-GMPCGFI------------------------- -----RQNSGNSISLDFEPNIEYQFVERLEERYKCAFCRSVLHNPHQTG----------- --------------CGHRFCQHCILSLR-------ELN--TVPICP---VDKE------- ---VIK-SQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------------- --------------------------------------DH--L-QQCLFQ-AVQCSNE-- ---NCQEPVLRKDLKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NHE-------- ---------------------------------------------ENLCPEYPVFCPN-- NCA---KIILKT-------EVDEHLA-VCPEAE--------QDCPFKHYGCAVT---DKR RNLQEHEHSAL---REHMRLVL--EKNVQLEEQISDLHKSL-EQKESKIQQLAETIKK-- ---------------------------LEKE---FKQFA-------QLFGKNGSFLPNIQ -VFASHIDKSAWLEAQV-----------HQLLQMVNQQQNKFDLRPLMEAVDTVKQKIT- LLENN--------DQRLAVLEEE--------------------------TNKH-----DT HINIHKAQLNKNEERFKL---------LEGTCYNGKLIWKVTDYK--MKKREAVDGHT-- VSIFSQSFYTGRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMRGEFDSLLQWPFRQR--- VTLMLLDQSGK------KN-IMETFKPD--PNSSS---FKRP------------DGE--M NI-ASGCPRFVAHSVLENAKN-AYIKDDTLFL---KVAVD-LTDLE-------------- -----DL----------------------- >H_sapiens_ENSP00000336825 -------------------MAYSEEHK-GMPCGFI------------------------- -----RQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTG----------- --------------CGHRFCQHCILSLR-------ELN--TVPICP---VDKE------- ---VIK-SQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ------------- --------------------------------------DH--L-QQCLFQ-PVQCSNE-- ---KCREPVLRKDLKE----HLSASCQFRKEKCLYCKKDVVVINL-Q--NHE-------- ---------------------------------------------ENLCPEYPVFCPN-- NCA---KIILKT-------EVDEHLA-VCPEAE--------QDCPFKHYGCAVT---DKR RNLQQHEHSAL---REHMRLVL--EKNVQLEEQISDLHKSL-EQKESKIQQLAETIKK-- ---------------------------LEKE---FKQFA-------QLFGKNGSFLPNIQ -VFASHIDKSAWLEAQV-----------HQLLQMVNQQQNKFDLRPLMEAVDTVKQKIT- LLENN--------DQRLAVLEEE--------------------------TNKH-----DT HINIHKAQLSKNEERFKL---------LEGTCYNGKLIWKVTDYK--MKKREAVDGHT-- VSIFSQSFYTSRCGYRLCARAYLNGDGSGR-GSHLSLYFVVMRGEFDSLLQWPFRQR--- VTLMLLDQSGK------KN-IMETFKPD--PNSSS---FKRP------------DGE--M NI-ASGCPRFVAHSVLENAKN-AYIKDDTLFL---KVAVD-LTDLE-------------- -----DL----------------------- >T_guttata_ENSTGUP00000003276 -------------------MA-CDEPA-ALSGIFT------------------------- -----RQNSSSTSSLDFEPHADYRFVESLEERYKCAYCHLVLRNPHQTG----------- --------------CGHRFCQQCILALR-------ELN--AVPTCP---VDKE------- ---TIK-MHE--VFKDNCCKREVLNLHVFCKN-FPDCSSKVILGRYQ------------- --------------------------------------EH--L-QQCLFE-CTQCTND-- ---GCRDRVLRKDLKE----HLRQQCKFREERCQYCNTYVVFINI-E--NHE-------- ---------------------------------------------KNDCPDYPVPCLQ-- NCS---QIILKK-------EIEKHHA-VCPEAE--------VDCPYKQYGCHVK---VKR GKLAEHENSAL---REHMLQIL--DKNSRLEEQISDLYKNL-EYKEIKIQQLADAIKK-- ---------------------------CEKE---FRQYT-------QLFGNNSNLMVSTQ -ALASHLDKSARLESQV-----------KQLIQMANQQQSKLDLQPLLDTIENVKQKIA- LMETY--------DQRLVVLEDQ--------------------------SSKH-----DL QINIHKAQLNKNEERFKL---------LEGTCYNGKLIWKITDYQ--KKKREAVEGRV-- LSIASQPFYTSRCGYRLCARAYLNGDGSGK-GTHISLYFVVMRGEFDSLLLWPFKQK--- VTLMLLDQSGK------KNHIVDVFRAD--PNSSS---FKRP------------DGE--M NI-ASGCPRFVPHTVLESTKN-TYIRDDTLFL---KVVVD-LTDLE-------------- -----EL----------------------- >B_taurus_ENSBTAP00000015940 -------------------MAYFEEQG-GVPCGFT------------------------- -----RQNSGNSISLDFEPDAEYQFVERLEERYKCAFCHSVLHNPHQTG----------- --------------CGHRFCHQCILALR-------ELD--TVPLCP---VDKE------- ---VIK-SQE--VFKDNCCKREVLNLYVFCKN-APRCNAKIILGRYQ------------- --------------------------------------DH--L-QHCLFQ-PVQCSNE-- ---NCREPVLRKDLKE----HLSAYCQFREEKCLYCKKDVVVINL-Q--NHE-------- ---------------------------------------------ENLCPDYPVSCPN-- KCL---QTIPRT-------EVDEHLA-VCPEAE--------QDCAFKNYGCAVK---DKR GNLQEHERSAL---RDHMLLVL--EKNFQLEEQISDLYKSL-EQKESKIQQLAEMVKK-- ---------------------------FEKE---FKQFA-------QLFGKNGSFLSNMQ -VLASHIDKSAWLEVQV-----------RQLLQMANQQQSKFDLKPLVEAIDTVKQKIT- LLETN--------DQRLVVLEGE--------------------------TNKH-----DA HINIHKAQLNKNEERFKL---------LESACYNGKLIWKVTDYK--LKKKEALDGHT-- VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMRGEFDSLLQWPFRQR--- VTLMLLDQSGK------KNHIMETFKAD--PNSSS---FKRP------------DGE--M NI-ASGCPRFVAHSTLENAKN-TYIKDDTLFL---KVAVD-LTDLE-------------- -----DL----------------------- >D_rerio_ENSDARP00000014326 ------------------------------------------------------------ ----------------------------LEQQFICPSCGGIVLNPHQTG----------- --------------CGHIFCAQCVKAYT-------ENG--GSSKCP---LDSI------- ---PIK-PEE--IFQDNCCKRELLNLEVFCTN-APECTQRFSLCNLQ------------- --------------------------------------DH--L-KACPHE-RVRCSHS-- ---DCSDIVLRKNLLE----HQRNACSYRLETCHYCRQNFPVSQMMQ--GHQ-------- ---------------------------------------------KSSCPDVEVPCSN-- NCT---QMIKRH-------QLQAHAD-ECLEVE--------TDCVYKNYGCTVR---DKR GKVQVHENTEF---SAHVRLVL--EKLCEQTLCSLTMQSRV------------------- -----------------------------------------------------STFSCDR RSVEEQRVRICSVQREL---------------------------RDLRVLGSELKEELPR L------------QASLDSLRQQ-----------------------------------VA VTESLREHLVALKQHSTF---------LESSSYDGKLIWKVRDYW--HRKESG------- AALSSSPFYTSRSGYKLSVRAYLGGDGSGR-GSHMSLYITIMRGDFDSFLPWPFRQN--- ITLTLLDQSGT------RNHMSHTFIPD--VNSDS---FHRP------------TSD--A NV-ATGFTRFISHCDLENPRNAVFVRDETLFI---KVKV--------------------- ------------------------------ >C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------M-A--PENLSQM--------------------------VDAF-----ER QLGMYDVRIADMDQRFQV---------IETTSYSGVVIWKIRDFS--RRKREAVSGRT-- LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFFVVMKGEYDALLPWPFRQK--- VTLMLLDQGMD------RRHLSDTFRPD--PTSSS---FKKP------------TSD--M NI-ASGCPLFVAHNVIEDS---SYVKEDTIFL---RIHVD-TSDLE-------------- -----NF----------------------- >G_gallus_ENSGALP00000016021 -------------------MA-CDELT-GVSGIFT------------------------- -----RQNSASAVSLDFEPDTDYKFVETLEDRYKCAYCHSVLHNPHQTG----------- --------------CGHRFCQQCILTLR-------GLN--AVPTCP---VDKE------- ---TIK-MHE--VFKDNCCKREVLNLYVFCKN-LPDCNSKIILGRYQ------------- --------------------------------------EH--L-QQCLFE-SVQCTND-- ---GCCDQILRKDLKD----HLSQHCKFREEMCQYCNKYVVLINI-K--NHE-------- ---------------------------------------------ENDCPDYPMPCLQ-- NCS---QIILKK-------EIEKHHT-VCPETE--------VDCPYKQYGCLIK---VKR GKLAEHENGAL---REHMLQIL--DKNSRLEEQISDLYKSL-ECKEIKIQQLAEAVKK-- ---------------------------CEKE---FRQFT-------QLFGKNSNLMVSTQ -TLASHLDKSARLESQV-----------KQLIQMANQQQSKLDLRPLFDTIENVKQKIA- LMETY--------DQRLAVLESQ--------------------------SSKH-----DL QINIHKAQLNKNEERFKL---------LEGTCYNGKLIWKITDYK--MKKKEAVEGRV-- LSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHVSLYFVVMRGEFDSLLPWPFKQK--- VTLMLLDQTGK------KNHIVEVFRAD--PNSSS---FKRP------------DGE--M NI-ASGCPRFVPHTVLENTKN-TYVRDDTLFL---KVVVD-LTDLE-------------- -----EL----------------------- >A_carolinensis_ENSACAP00000016112 -------------------MASEDLAC-QVPNFYI------------------------- -----RQNSTNAVSLDFEPDASYQFVEILEDRYKCTHCHLVLHNPHQTG----------- --------------CGHRFCQRCIASLR-------ELS--VIPTCP---VDKE------- ---IIK-PHE--VFKDNCCKREVLNLQVYCRN-SPACNAKTSLGRYQ------------- --------------------------------------DH--L-QQCLFE-SVQCTNE-- ---GCCEKVLQKDLKE----HLGLHCNYRKELCRYCNQPVTSINV-K--THE-------- ---------------------------------------------RRDCPEYPLICPH-- GCT---QTILMK-------EAEEHIL-VCPAVE--------IDCPYKQYGCPAK---IKR GKVLEHENIYL---REHMLQIL--DRNSKLEDQISELYKNL-EHKEIKIQHLADMVKK-- ---------------------------CEKE---FRQFT-------QLYSKNNNLLASTQ -TLAIHIDKSACLETQV-----------RQLVQMANQQQSKFDLRPLLETVENIKQKVA- FLESY--------EQRLVVLEDL--------------------------SSQH-----DI HLGLHKAQLNKNEERFKL---------LEGTSYNGKLIWKIVDYK--TKKKEAVEGSC-- LSIFSQPFYTSRCGYRLSTRAYLNGDGSGK-GTHVSLYFVVMRGEFDSLLPWPFRQK--- VTLMLLDQSGK------KNHIVETFKAD--PNSSS---FKRP------------EGE--M NV-ASGCPRFVPHTLLENAKS-TYIKDDTIFL---KVVVD-LTDLE-------------- -----EL----------------------- >M_domestica_ENSMODP00000003305 -------------------SLTSAEYG-SASGDFL------------------------- -----PQNSSSYISLDFEPNIDYQFVEQLEERYKCASCHSVLHNPHQTG----------- --------------CGHRFCENCILSLR-------ELN--TVSICP---VDKE------- ---IIK-PKE--VFKDNCCKREVLNLQVFCKN-APHCAAKMILGRYQ------------- --------------------------------------DH--L-LQCLFQ-SVQCSNE-- ---CCQERILRKDLKN----HLELHCQFREEMCPFCNKDVVIIDL-Q--NHK-------- ---------------------------------------------EQFCPNYPVSCPN-- NCL---QIITRT-------KVNEHIS-VCPEVE--------QECAYKHYGCPVK---DKR SNLKKHENSAL---REHMLLVL--ERNSRLEEQIFDLHKNL-ELKESKIQQLSETVKK-- ---------------------------FEKE---FRQFV-------QLFGKNGNLLASTQ -VLASHIDKSAWLETQV-----------RELLELANQQENKLDLKPLINTIDTIKQKIT- LLETY--------DQRLVTLEGQ--------------------------TNRH-----DV HINVHKAQLNKNEERFKM---------LEGTCYNGKLIWKVTDYK--MKKKEATEGRT-- VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMKGEFDSLLQWPFKQR--- VTMMLLDQSGK------KNHITEIFKAD--PNSSS---FKRP------------DGE--M NI-ASGCPRFVAHSTLESTKN-TYIKEDTLFM---KVVVD-LSDLE-------------- -----DL----------------------- >C_intestinalis_ENSCINP00000001022 -------------------MDTAD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------S--RHQ-------- ---------------------------------------------SGENSSFASSQPE-- --SV--DQIPQN-----------HLN-ESPYVL--------NNEALSLESSLTT---GDL NSVKAQCEYSH---KILQRQLQ--EMKNAVE-----LEMRK-RESDRDGNVLRANITK-- ---------------------------L------------------------EQRLTALQ RMTAQQTDRSLALKKEVGDNDAANKRANTDLTQK---VE---EIAREIAQIKEKQNELER KIESTSSSREQM-A--PENLSQM--------------------------VDAF-----ER QLGMYDVRIADMDQRFQV---------LETTSYSGVVIWKIRDFS--RRKREAVSGRT-- LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFFVVMKGEYDALLPWPFRQK--- VTLMLLDQGMD------RRHLSDTFRPD--PTSSS---FKKP------------TSD--M NI-ASGCPLFVAHNVIEGS---SYVKEDTIFL---RIHVD-TSDLE-------------- -----NF----------------------- >C_intestinalis_ENSCINP00000027890 -------------------M---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------L-------- ---------------------------------------------STENVS-PSLQRS-- --SV-----FNS-----------WTS-KSPIDF--------SISEPSFNFNGLS---HPE VGISDYCKSEH---DALRSHLA--EISQTL-------------NNLKNSNDVSPEIRK-- ---------------------------L------------------------EVRLKAIQ RMTAQQTDRSLALKKEVGDNDAANKRANTDLTQK---VE---EIAREIAQIKEKQNELER NIESTSGSREQM-A--PENLSQM--------------------------VDAF-----ER QLGMYDVRIADMDQRFQV---------IETTSYSGVVIWKIRDFS--RRKREAVSGRT-- LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFFVVMKGEYDALLPWPFRQK--- VTLMLLDQGMD------RRHLSDTFRPD--PTSSS---FKKP------------TSD--M NI-ASGCPLFVAHNVIEDS---SYVKEDTIFL---RIHVD-TSDLE-------------- -----NF----------------------- >M_mulatta_ENSMMUP00000015419 -------------------MESSKKM---DSPGPLQTNPPLKLHT--------------- -----DRSAGTPIFAPEQGGYKEKFVKTVEDKYKCEKCRLVLCSPKQTE----------- --------------CGHRFCESCMAALL-------S-S--SSPKCT---ACQE------- ---SVV-RDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------------- --------------------------------------VH--LKNDCHFE-ELPCVRA-- ---DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMIAL-Q--KHE-------- ---------------------------------------------DTDCPCVVVSCPH-- KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIK---------------------------------- ------------------------------ >G_gallus_ENSGALP00000002401 ------------------------------------------------------------ -PRAGPAGGPGADAAVLPGGSRRGVGDVPEQKYLCSNCNNVLKKALQTL----------- --------------CGHRYCSACLSWIV-------RNN--KNPVCQ---KCKEEDPSTLS EGSLLA-EER--AFGDAAINKEISELRVHCVTLG--CSWCGTMKNFE------------- --------------------------------------EH--Q-ILCEYA-LIPCHT--- ---GCGHVVMRKKLAD----HLENGCVNNVTVCHKCKQSLSSSEY-Q--P---------- -----------------------------------------------HCPRKPKVCRS-- -EPAVILMTGTF-------MLSDHLR-ASSVSM--------DGCRFSEVGCSFG---GSK EKIKEHEKAAV---GTHMLLLL--QYIKQLKANLCTVSK--------------------- ----------------------------------AANGFISQTEL-----NLENKLHVFE NIVAV-------LNKEV-------------------------ETSNLEITAFRRQSELD- -------------QNVIRGLELK--------------------------IAEL-----HH CLTQKDAGLSRLHKSLVF---------SEQTSYDGVFLWKITDVN--QKLQDSVTGRV-- VSLYSPAFYTAKYGYKVCLRIYLNGDGMGK-GTHVSLFFVVMKGDYDALLPWPFRHK--- VTFMLLDQNNR-------EHIIDAFRPD--LASAS---FQRP------------VND--M NV-ASGCPTFLPLTKLQSPKH-AYVKEDTLFL---KCIID-LTAV--------------- ------------------------------ >O_anatinus_ENSOANP00000013484 -------------------SMGSEELT-IGSRAFS------------------------- -----HQNSSSCISLDFEPDIQYQFVEQLEERYKCTFCHSVLHNPHQTS----------- --------------CGHRFCQHCILSLR-------ELN--NFPTCP---IDKK------- ---IIQ-LQE--VFKDNCCKREVLNLQVFCKN-APGCNSKMILGRYQ------------- --------------------------------------DH--L-QQCLFQ-PVQCSNE-- ---SCQEKVLRKDMKD----HLGCHCKFREEKCQYCQKYVVAIDL-Q--NHE-------- ---------------------------------------------ENFCPDYPVSCPF-- SCC---QIIPRT-------EVDEHIS-VCPEAE--------QDCPYKQYGCLIK---DKR RNLREHENAAL---REHMLLVL--DKNSRLEEKISDLHRSL-EVKELKIQQLAEMVKK-- ---------------------------FEKE---FRQVM-------QLFSKNGNLLANTQ -ILANHIDKSTWLETQV-----------RQLLHMANQQQSKFDLKSLMETIDTVKQKIA- LLETY--------DQRLVVLKDQ--------------------------TRQH-----DA HINAHKAQLNKNEERFKL---------LEGTCYNGKLIWKVTDYK--MKKREAMEGRS-- VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMKGEFDSLLQWPFKQK--- VTMMLLDQSGK------KNHIVEIFKAD--PNSSS---FKRP------------EGE--M NI-ASGCPCFVDHSKLENVKN-TFIKEDTLFM---KVVVD-LTDLE-------------- -----EL----------------------- >O_cuniculus_ENSOCUP00000007884 -------------------MAYSEEPG-GIHLGFI------------------------- -----RQNSGSSISLDFEPNAEYRFVEQLEERYKCAFCHSVLHNPHQTG----------- --------------CGHRFCQHCILSLR-------ELN--TVPICP---VDKE------- ---VIR-SQE--VFKDNCCKREVLNLHVYCKN-APGCNAKVILGRYQ------------- --------------------------------------EH--L-QQCLFQ-VVQCSHD-- ---SCQEPVLRRDLNE----HLSAYCQFREEKCLYCKKDVVVMDL-Q--NHE-------- ---------------------------------------------ENLCPEYPVSCPN-- KCL---QIIPRT-------EVNRHLA-VCPEAE--------QDCPFKQYGCTVK---EKR GSLQEHEHSAL---REHMLLVL--EKNFRLEEQISDLCKSL-EQKESKIQQLAETVKK-- ---------------------------FEKE---FKQFA-------QLFGKNGSFLSNIQ -XXXXXXXXXXXXXXXX-----------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX- XXXXX--------XXXXXVLEGE--------------------------TSKH-----DA HINIHKAQLNKNEERFKL---------LEGACYNGKLIWKVTDYK--MKKKEAVDGHT-- VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMRGEFDSLLQWPFRQR--- VTLMLLDQSGK------RNHIMETFKAD--PNSSS---FKRP------------DGE--M NI-ASGCPRFVAHSTLENAKN-TYIKEDTLFL---KVAVD-LTDLE-------------- -----DL----------------------- >G_gorilla_ENSGGOP00000004192 -------------------MESSKKM---DSPGALQTNPPLKLHT--------------- -----DRSAGTPVFVPEQGGYKEKXXXXXXXXXXXXXXXXXXXXXXXXX----------- --------------XXXXXXXXXXXXXX-------X-X--XXXXXX---XXXX------- ---SIV-KDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL------------- --------------------------------------XX--XXXXXXXX-XXXXXXX-- ---XXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X--KHE-------- ---------------------------------------------DTDCPCVVVSCPH-- KCSV--QTLLRS-------ELSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ RVIDSQAEKLKELDKEI-----------RPFRQN---WE---EADSMKSSVESLQNRVT- ELESVDKSAGQV-ARNTGLLESQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FKKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >C_familiaris_ENSCAFP00000017853 -------------------MAYSEDQG-GVPCGFI------------------------- -----RQNSSNSISLDFEPHTEYRFVEPLEERYKCALCHSVLHNPHQTG----------- --------------CGHRFCQHCILSLR-------ELN--AVPLCP---VDKE------- ---VIK-SQE--VFKDNCCKREVLNLYVYCKN-APGCNAKIILGRYQ------------- --------------------------------------QYIWL-QYSTPR-AKVRVNRRS IGTSCKHTMCRGSEGE----LLSHETALPGSSILLGKQEACILSLSQ--NHE-------- ---------------------------------------------ENLCPEYPVPCPN-- KCS---QIIPRT-------EVDEHLT-VCPEAE--------QDCPFKHYGCTVK---DKR GSLQEHEHSAL---RDHMLLVL--EKNLQLEEQISDLYKSL-EQKESKIQQLAETVKK-- ---------------------------FEKE---FKQFA-------QLFGKNGSFLSNIQ -VLANHIDKSAWLEAQV-----------RQLLQMANQQQNKFDLRPLVEAIDTVKQKIT- LLETN--------DQRLVVLEGE--------------------------TNKH-----DA HINIHKAQLNKNEERFKL---------LEGACYNGKLIWKVTDYK--MKKREALDGHT-- VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYFVVMRGEFDSLLQWPFRQR--- VTLMLLDQSGK------KNHIMETFKAD--PSSSS---FKRP------------DGE--M NI-ASGCPRFVAHSTLENAKN-TYIKDDTVFL---KVAVD-LTDLE-------------- -----DL----------------------- >T_rubripes_ENSTRUP00000047803 -----------------------------MA----------------------------- -----RISMDCS--SSLPGIPLSVLSVPMENKYKCQQCLQVLRKPVQAQ----------- --------------CGHRFCIHCFKELT-------S-S--GPKPCE---ACRQEE-IYEE PISVLN-SNE--VFPDNAAGREIASLPARCLNQG--CSWTGSIKQYE------------- -------------------------------------AQH--E-GRCELE-QIKCD---- ---ACQASVLRAEIDR----HNERECEARTLNCKYCKLTFHFKDI-K--AHD-------- ---------------------------------------------D-ICLKFPLPCKD-- -CGK--KKIPRE-------KFNEHIR-SCAKSK--------SACPFSEVGCKSV---VDN GKLREHEHSST---VEHLHLLL--PMVLSLTRTRAEVSESG-EWQEDSGLGLYRAPEEGV ---------------------------NVGA---GAAAS-------VHAVDLEKKVTALE NIICV-------LNREV-------------------------ERSALKVEAFAHQHCLD- -------------QEKIENLVSK--------------------------VGQL-----ER AIAMRDLQLSETEQMVRE---------LQSCTYDGIFVWKISEFS--RRRQEAVAVRM-- PTMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFFVVMRGKCDALLKWPFSQK--- VTLMLLDQNNR-------EHIIDAFRPD--VTSSS---FQRP------------ISE--M NI-ASGCPLFCPLAKLA-GKS-PYLKDDTIFI---KAIVD-LTGL--------------- ------------------------------ >P_troglodytes_ENSPTRP00000036949 -------------------MA--------AA----------------------------- -----SVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQ----------- --------------CGHRYCSFCLASIL-------S-S--GPQNCA---ACVHEG-IYEE GISILE-SSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------------- -------------------------------------SCH--E-GRCPLM-LTECP---- ---ACKGLVRLGEKER----HLEHECPERSLSCRHCRAPCCGADV-K--AHH-------- ---------------------------------------------E-VCPKFPLTCDG-- -CGK--KKIPRE-------KFQDHVK-TCGKCR--------VPCRFHAIGCLET---VEG EKQQEHEAQWL---REHLAMLL--SSVLEAKPLSGDQ----------------------- ----------------------------SHA---GSELL-------QRCESLEKKTATFE NIVCV-------LNREV-------------------------ERVAMTAEACSRQHRLD- -------------QDKIEALSSK--------------------------VQQL-----ER SIGLKDLAMADLEQKVLE---------MEASTYDGVFIWKISDFA--RKRQEAVAGRT-- PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VND--M NI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- ------------------------------ >P_pygmaeus_ENSPPYP00000022191 -------------------MA--------AA----------------------------- -----SVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQ----------- --------------CGHRYCSFCLASIL-------S-S--GPQNCA---ACVHEG-IYEE GISILE-SSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------------- -------------------------------------SCH--E-GRCPLM-LTECP---- ---ACKGLVRLGEKER----HLEHECPERSLSCRHCRAPCCGADV-K--AHH-------- ---------------------------------------------E-VCPKFPLTCDG-- -CGK--KKIPRE-------KFQDHVK-TCGKCR--------VPCRFHAIGCLET---VEG EKQQEHEAQWL---REHLAMLL--SSVLEAKPLSGDQ----------------------- ----------------------------SHA---GSELL-------QRCESLENKTATFE NIVCV-------LNREV-------------------------ERVAMTAEACSRQHRLD- -------------QDKIEALSSK--------------------------VQQL-----ER SIGLKDLAMADLEQKVLE---------MEASTYDGVFIWKISDFA--RKRQEAVAGRT-- PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VND--M NI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- ------------------------------ >T_nigroviridis_ENSTNIP00000011878 -----------------------------MA----------------------------- -----RISLDCS--PSLPGIPLSVLSVPMENKYKCQQCLQVLRKPVQAQ----------- --------------CGHRFCVHCFRELT-------S-S--GPKPCE---ACRQEE-IYEE PTSILN-SNE--VFPDNAAGREIASLPARCLNQD--CSWTGSIKQYE------------- -------------------------------------AQH--E-GRCEFE-QIKCD---- ---ACQAFVLRAEKDR----HNERECEARTLNCKYCKFTFHFKDI-K--AHD-------- ---------------------------------------------E-ICSKFPLQCKD-- -CGK--KKIPRE-------KFNEHIK-SCAKSK--------SACPFSEVGCKSV---VEN GKLSEHENSST---MEHMRLLL--PIVLSLTQARAEVSDSG-EWQEDSVLGLYRAPEEGV ---------------------------HVGA---GAAAS-------VH-VNLEKKVTALE RIVCV-------LNREV-------------------------ERSTAMLEAFAHQHALD- -------------QEKIENLSTK--------------------------LGQL-----ER VIAMRDLQLSETEQMVRE---------LQSCTYDGIFVWKISEFS--RRRQEAVAGRT-- PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFFVVMKGKCDALLKWPFSQK--- VTLMLLDQNNR-------EHIIDAFRPD--VTSSS---FQRP------------ISE--M NI-ASGCPLFCPLAKLA-GKS-PYLKDDTIFI---KAIVD-LTGL--------------- ------------------------------ >T_nigroviridis_ENSTNIP00000016461 -------------------MA--------AQ----------------------------- -----EPSPPSSMESNKPGFPKKILGNKLEDKHLCNCCHNILRRPFQAQ----------- --------------CGHRFCSYCFTRTV-------S-N--GPQKCS---ACIKED-IFED PTSILK-QGC--AFPDNAVRREVEHLPAVCINEN--CTWKGTIKEYE------------- -------------------------------------LSH--E-GKCEFM-IISCP---- ---SCKEHIRFNEQER----HNERECPERTLNCKYCKEPFHFKNI-K--AHD-------- ---------------------------------------------E-ICPKYPMICEG-- -CAK--KKIPRE-------KYVDHIK-FCSKFR--------TPCRFHVVGCDMS---VEK EKIHDHERAFA---YEHLNLLL--HYIMGMKASRAG------------------------ ---------------------------EKTK---VAELG-------RRCTELEVKANTFE NVVCV-------LNREV-------------------------ERFATTMEASNRQHKLD- -------------QDKIEALSNK--------------------------VRQL-----ER TVGLKDLTVAEMEGRLRE---------MSATTFDGVFVWRISDFA--KKRQDAIAGRA-- PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFFVVMRGQSDALLKWPFNQK--- VTLMLLDQSNR-------EHIIDAFRPD--VTSSS---FQRP------------VSE--M NI-ASGCPLFCPLSKLD-GKN-SYIRDDTIFI---KAIVD-LTGL--------------- ------------------------------ >D_rerio_ENSDARP00000069217 ----------------MISAAGTLCKWKDME----------------------------- -----RPSLPSSLDSTLPGISREVLSVSMEPKYQCQQCKDILRKPFQAQ----------- --------------CGHRFCVFCFKQLT-------S-S--GPIPCE---ACRAEG-IFEE ETSVLN-IAV--AFPDNAARREIDSLPAKCPNEG--CSWSGTLKDFE------------- -------------------------------------NQH--E-GRCAFE-RVKCE---- ---ACQVLILLSEKDR----HNERECEARTLNCKYCKVTFNFKEI-K--AHD-------- ---------------------------------------------E-ICQKFPMQCKD-- -CGK--KKIPRE-------KFQEHTK-SCAKSK--------SACQFREIGCRAV---VDN CKQQEHEQTSI---MEHLRLML--ALLSSMRLR---AEGAG-EWQEDVGLGLYRGPEDAP ---------------------------PAGA---HNVGR-------GGGPGVQKKVTTLE NIVCV-------LNKEV-------------------------ERSALTMEAISRQHRLD- -------------QEKIENLSNK--------------------------VRQL-----ER TLTTRDLQLAESEQSLRE---------LQFCTYDGVFIWKIAEFS--RRRQDAVAGRA-- PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GSHLSLFFVVMKGKYDALLKWPFSQK--- VTLMLLDQNNR-------EHIIDAFRPD--VSSTS---FQRP------------ISE--M NI-ASGCPLFCPLAKLA-GKS-SYLRDDTIFI---KAIVD-LTGL--------------- ------------------------------ >T_guttata_ENSTGUP00000006737 ------------------------------------------------------------ --------------------------DVPGHKFLCSNCNNILKKALQTL----------- --------------CGHRYCSACLAWIL-------RNN--KNAICQ---KCKEEDPNTLG EESLLA-EER--AFGDAAINKEISELRVHCVTLG--CSWSGIMKDFE------------- --------------------------------------EH--Q-SLCEYA-LIPCHT--- ---GCGHVVMRRKLAD----HLENGCVNNVTVCQQCQCSLATSEC-Q--V---------- -----------------------------------------------RTFLSQIKA---- -FQLVLIISSTF-------FFSSH-S-TSSSNK--------DGCCFSEVGCAFR---GSK EKIQEHQNSAV---GAHMLLLL--QHMRQLQGTLC------------------------- -----------------------------------SKGFSPRPELNKVISELENKLHVFE NIVAV-------LNKEV-------------------------ESSNLEIQAFRRQSELD- -------------QNVIRGLELK--------------------------IAEL-----HQ CLTQKDAGLSSLHKSLLF---------SEQASYDGIFLWKITEVA--RKLQDSVTGRT-- VSLYSPAFYTAKYGYKVCLRVYLNGDGTGK-GTHMSLFFVVMKGDYDALLPWPFRHK--- VTFMLLDQNNR-------EHIIDAFRPD--LTSAS---FQRP------------VND--M NV-ASGCPMFLPLAKLQSPKH-GYVREDTLFL---KCIIE-------------------- ------------------------------ >O_cuniculus_ENSOCUP00000003184 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------S--SSPKCT---ACQE------- ---SIV-KDK--VFKDNCCKREILALQICCRNESRGCAEQLALGHLL------------- --------------------------------------VH--LKNDCQFE-ELACVRA-- ---DCKEKVLRKDLRD----HVEKACKYREATCSHCKSQVPMITL-Q--XXX-------- ---------------------------------------------XXXXXXXXXXXXX-- XXXX--XXXXXX-------XLSAHLS-ECVNAP--------STCSFKRYGCVFQ---GTN QQIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-VEKNKSIQSLHNQICS-- ---------------------------FEIE---IERQK-------EMLRNNESKILHLQ XXXXXXXXXXXXXXXXX-----------XXXXXX---XX---XXXXXXXXXXXXXXXXX- XXXXXXXXXXXX-XXXXXLLESQ--------------------------LSRH-----DQ MLSVHDIRLADMDLRFQV---------LETASYNGVLIWKIRDYK--RRKQEAVMGKT-- LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDALLPWPFKQK--- VTLMLMDQGSS------RRHLGDAFKPD--PNSSS---FRKP------------TGE--M NI-ASGCPVFVAQTVLENG---TYIKDDTIFI---KVIVD-TSDLP-------------- -----DP----------------------- >O_latipes_ENSORLP00000001368 ------------------------------------------------------------ ----------LAGRLQTHGVVRNHFVMKLKEEFICPICKGVVLNPQQNS----------- --------------CGHIYCFHCLQGLL-------ESSLLSGPVCP---VEKA------- ---AIT-PSE--VFQDNCCKREISSLEVYCTN-SPLCTSVLALNQLQ------------- --------------------------------------EH--L-KSCQYE-QLLCSNP-- ---GCTELLQRRLLQE----HLNATCPHRRESCPHCLQPFQLSVI-Q--DHV-------- ---------------------------------------------QSSCPKVKGGCPD-- GCS---TLVPKN-------RLTEHGE-SCPEVH--------TDCSFKMFGCSVK---GKR RKVKLHEEAAV---CHHVLLVL--KSSAHLEQQVVFVQKEA-LLRQQEVQTDTLLLSD-- ---------------------------LQEQ---LGSVL-------QQSRSQEHIVATAQ ACLDEHRADILEMENEL-----------------LAAETLREHIGNQTGNSRSVKLRSA- TLCTGVFLFYIKCHLMSATLEEN--------------------------RKRH-----SG LLELHVAQLALNKQHLQE---------LELTSYDGRLIWKIKDFQ--KRREAEATGQH-- PCLSSVPFHTGRCGYKMAMKAYLNGDGEGR-GTHLSLYVVLMPGDFDALLPWPFKQT--- VSLSVLDQSGA------RNHQSFNFRPD--PTNTC---FHQP------------AAESAS NV-AVGFPCFISLDALEAPGNAVYVKDDTLFV---KVKVD-TTGLE-------------- ------------------------------ >H_sapiens_ENSP00000247668 -------------------MA--------AA----------------------------- -----SVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQ----------- --------------CGHRYCSFCLASIL-------S-S--GPQNCA---ACVHEG-IYEE GISILE-SSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------------- -------------------------------------SCH--E-GRCPLM-LTECP---- ---ACKGLVRLGEKER----HLEHECPERSLSCRHCRAPCCGADV-K--AHH-------- ---------------------------------------------E-VCPKFPLTCDG-- -CGK--KKIPRE-------KFQDHVK-TCGKCR--------VPCRFHAIGCLET---VEG EKQQEHEVQWL---REHLAMLL--SSVLEAKPLLGDQ----------------------- ----------------------------SHA---GSELL-------QRCESLEKKTATFE NIVCV-------LNREV-------------------------ERVAMTAEACSRQHRLD- -------------QDKIEALSSK--------------------------VQQL-----ER SIGLKDLAMADLEQKVLE---------MEASTYDGVFIWKISDFA--RKRQEAVAGRI-- PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VND--M NI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- ------------------------------ >T_nigroviridis_ENSTNIP00000013509 -------------------MA--------SQ----------------------------- -----EPSPPSSLEGNKPGFPRKILANNLESKHLCKSCQKVLRRPLQAQ----------- --------------CGHRFCCFCFRKIV-------S-A--GPQTCR---ACISED-LFEE PASILK-SGG--AFPDNAARREVEALAAVCPNEG--CTWTGTIKEFE------------- -------------------------------------ARH--E-DSCDFM-IILCP---- ---SCKELMRANEQER----HNERECPERTLNCKYCKEAFQLKSI-K--AHD-------- ---------------------------------------------E-ICPKYPMMCEG-- -CSR--RKIPRE-------KYVDHIK-YCSKFK--------SPCRFHVVGCNIK---VEK EKIHEHERQCS---YEHLNLLL--HFIMGIKSS--------------------------- ----RA---------------------KKTK---VAELS-------RRCQELEVKVSTLE NIACV-------LNREV-------------------------ERSCTTMDAYNRQHRLD- -------------QDKIEILNNK--------------------------VRQL-----ER TVSLRDLSIVEMDEKMRE---------LSAATYDGVFVWKIADFT--KKRQDAVAGRA-- PAMFSPAFYTSKYGYKMC-RIYLNGDGTGR-GSHLSLFFVVMRGHSDALLKWPFNQK--- VTLMLLDQNNR-------EHIIDAFRPD--VSSSS---FQRP------------VSD--M NI-ASGCPLFCPLSKLD-CKN-SYIRDDTIFI---KVIVD-LSGL--------------- ------------------------------ >M_musculus_ENSMUSP00000109872 -------------------MA--------AA----------------------------- -----SVTSPGSLELLQPGFSKTLLGTRLEAKYLCSACKNILRRPFQAQ----------- --------------CGHRYCSFCLTSILRCASILSS-S--GPQNCA---ACVYEG-LYEE GISILE-SSS--AFPDNAARREVESLPAVCPNDG--CTWKGTLKEYE------------- -------------------------------------SCH--E-GLCPFL-LTECP---- ---ACKGLVRLSEKEH----HTEQECPKRSLSCQHCRAPCSHVDL-E--VHY-------- ---------------------------------------------E-VCPKFPLTCDG-- -CGK--KKIPRE-------TFQDHVR-ACSKCR--------VLCRFHTVGCSEM---VET ENLQDHELQRL---REHLALLL--SSFLEAQASPGTL----------------------- ----------------------------NQV---GPELL-------QRCQILEQKIATFE NIVCV-------LNREV-------------------------ERVAVTAEACSRQHRLD- -------------QDKIEALSNK--------------------------VQQL-----ER SIGLKDLAMADLEQKVSE---------LEVSTYDGVFIWKISDFT--RKRQEAVAGRT-- PAIFSPAFYTSRYGYKMCLRVYLNGDGTGR-GTHLSLFFVVMKGPNDALLQWPFNQK--- VTLMLLDHNNR-------EHVIDAFRPD--VTSSS---FQRP------------VSD--M NI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- ------------------------------ >M_domestica_ENSMODP00000021625 -------------------MA--------TA----------------------------- -----NSTPPGSLDLLQPGFSKDILGTKLEDKYLCSACKNILRRPFQAQ----------- --------------CGHRYCSYCLTSII-------S-T--GPQNCA---ACIQEG-IYEE GISILE-SSS--AFPDNAARREVESLPAVCVNDG--CTWKGTIKEYE------------- -------------------------------------SCH--E-GHCSFM-LIECP---- ---ACKWMIKLGEKEH----HSERECPKRSLNCRYCKALFYYPDI-K--AHD-------- ---------------------------------------------E-ICPKFPLTCEG-- -CGK--KKILRE-------KFQDHVK-ACGKCK--------GPCKFHVVGCTEM---VEN EKQQDHENQKV---AEHLCMLL--NFVLEARHFHGDI----------------------- ---------------------------EMSK---STELL-------ERCETLERKTVTFE NIVCV-------LNREV-------------------------ERVSMTAEACSRQHRLD- -------------QEKIETLSSK--------------------------VQQL-----ER SIGLKDLAMADMEQKILE---------MEASTYDGIFIWKITDFA--RKRQEAMAGRS-- PAIFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VSD--M NI-ASGCPLFCPVSKME-SKN-SYVRDDAIFI---KAIVD-LTGL--------------- ------------------------------ >G_aculeatus_ENSGACP00000006974 -------------------MA--------AQ----------------------------- -----EQSPPSSLEGNKPGFPKKILANSLEDKHLCNSCQKVLRRPLQAQ----------- --------------CGHRFCSFCFNKIV-------S-S--GPQKCS---ACIKED-LFED PTSILK-QGG--AFPDNAARREVEALAAVCPNEE--CTWTGTIKEFE------------- -------------------------------------ASH--E-DNCDFM-IIMCP---- ---SCKELMRANEQER----HNERECPERTLNCRYCKEPFLLKNI-K--AHD-------- ---------------------------------------------E-ICPKYPMICEG-- -CAK--KKIPRE-------KYVDHIK-FCSKCK--------APCRFHVVGCDASVMEVEN EKLHDHERQCS---YEHLNLLL--HFIMGIK----------------------------- -LQLQS---------------------EKAK---VAELS-------RRCQELELKVGTFE NIACV-------LNREM-------------------------ERSCSTMEAYNRQHRLD- -------------QDKIEILNNK--------------------------VRQL-----ER TVSLRDLSIVEMEGKMRD---------MSAATYDGIFVWKISDFT--KKRQDAVAGRA-- PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMRGHSDALLKWPFNQK--- VTLMLLDQNSR-------EHIIDAFRPD--VSSSS---FQRP------------VSD--M NI-ASGCPLFCPLPKLD-SKN-SYIRDDTIFI---KAIVD-LTGL--------------- ------------------------------ >O_latipes_ENSORLP00000008989 -----------------------------MA----------------------------- -----RISWDSL--SSLPGIPLSVLSVPMEDKYKCQQCLQVLRKPVQAQ----------- --------------CGHRFCVHCFRQLT-------S-S--GPKPCQ---ACRKEE-IYEE PMSILN-SSE--AFPDNAAGREIASLPARCLNQG--CDWTGSIKEYE------------- -------------------------------------AKH--E-GRCEFE-QIQCE---- ---ACQALVLRKDKDR----HNDRECEERTLNCKYCKVTFNFKDI-K--AHD-------- ---------------------------------------------E-ICQKFPLQCKD-- -CGK--KKIPRE-------KFNDHAK-SCAKSK--------SACPFSEVGCKSV---VEN GKISEHEHSST---MEHLRLLL--PMVLSMTRTRLDTSPSG-EWQEDSGLGLYRAPDD-- -----------------------------GC---GAAAS-------VPSVDLDKKVSALE NIVCV-------LNREV-------------------------ERSSLTLEAFSHQHRLD- -------------QEKIENLSNK--------------------------IRQL-----ER SLTVKDLQLSEAEQMVRE---------LQYCTYDGIFVWKITDFS--HRRQEAVSGRA-- PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFFVVMRSKYDALLKWPFSQK--- RTIWAASKPNR------EEHIIDAFRPD--ITSTS---FQRP------------VSE--M NI-ASGCPLFCPLAKLA-GKS-PYLRDDTIFI---KAIVD-LSGL--------------- ------------------------------ >G_gallus_ENSGALP00000014649 -------------------MA--------AA----------------------------- -----NSTPPGSLDLSQPGFAKEILGTKLEVKYLCSDCRNILRRPFQAQ----------- --------------CGHRYCSYCLKKII-------S-S--GPQKCA---SCIQEG-IYEE GISILE-TSS--AFPDNAARREVESLPAVCINEG--CTWKGTIKEYE------------- -------------------------------------SCH--E-GNCPFL-LIECQ---- ---ACRGVIPLNEKER----HSERECPERTLNCKYCKSLFYFPDI-K--AHD-------- ---------------------------------------------E-VCPKFPLTCDG-- -CGK--KKIPRE-------KFQDHVK-NCGKCK--------VPCRFKVVGCAEM---VEN EKLPEHESKCL---AEHLYMLL--SFVLSLKSGSGDLKHLPAIPSSQSSSPLLAANSLCP E-------------------------SELFK---SLELL-------GRCDALEKKTVTFE NIVCV-------LNREV-------------------------ERVSLTAEAYSRQHRLD- -------------QEQIETLSNK--------------------------VRQL-----ER SIGLKDLAMAEMEEKIRN---------MEASTYDGVFIWKITEFA--RKRQEAITGRS-- PAIFSPAFYTSKYGYKMCLRVYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- VTLMLLDQNNR-------EHIIDAFRPD--VTSSS---FQRP------------VTE--M NI-ASGCPLFCPVSVME-AKN-SYVRDDAIFI---KAIVD-LSGL--------------- ------------------------------ >O_latipes_ENSORLP00000020860 -----------------------------QQ----------------------------- -----EPSPPSSLEGSKPGFPRKILANCLEDKHLCNSCEKILRRPLQAQ----------- --------------CGHRFCCFCFNRTV-------S-S--GPQKCS---ACIKED-LFEE PTSILK-QGG--AFHDNAARREVEALAAVCPNEG--CTWTGTVKEYE------------- -------------------------------------ASH--E-GSCDFT-IIMCP---- ---SCKELMRANEQER----HNERECPERTLNCKYCKEPFLLKNI-K--AHD-------- ---------------------------------------------E-ICPKYPMMCEG-- -CAK--KKIPRE-------KYVDHIK-FCSKFK--------APCRFHVVGCDTS---VEK EKIHDHERQCS---YEHLNLLL--HFIMGIKGVCAATLATS-------FTPLHSAMGAAL ELQLQS---------------------EKTK---VAELS-------RRCQELELKVSTFE NIVCI-------LNREL-------------------------ERSCATMEAYNRQHRLD- -------------QDKIEILSNK--------------------------VRQL-----ER TVSLRDLSIVEMEGKMKD---------MSAATYDGIFIWKISDFT--KKRQDAMAGRA-- PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMRGHSDALLKWPFNQK--- VTLMLLDQNNR-------EHIIDAFRPD--ISSSS---FQRP------------VSD--M NI-ASGCPLFCPLSKLD-SKN-SYIRDETIFI---KAIVD-LSGL--------------- ------------------------------ >E_caballus_ENSECAP00000011150 -------------------MA--------AA----------------------------- -----SVTPPGSLDLLQPGFSKTLLGTKLEDKYLCSACKNVLRRPFQAQ----------- --------------CGHRYCSYCLTSIL-------S-S--GPQNCA---ACVHEG-IYEE GISILE-SSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE------------- -------------------------------------SCH--E-GHCPFM-LTECP---- ---ACKGLVRLGEKEH----HLEHECPERSLSCRHCRAPCCWADM-K--AHH-------- ---------------------------------------------D-VCPKFPLTCDG-- -CGK--KKISRE-------KFQDHVR-TCGKCR--------VPCRFHAVGCPEM---VES EKQQEHEAKWL---QEHLAMLLDSSSFLGQSQVGNPG----------------------- --------------------------AEVSK---AAELL-------QRCEALERKTATFE NIVCV-------LNREV-------------------------ERVAMTAEACGRQHRLD- -------------QDRIEALSNK--------------------------VQQL-----ER SIGLKDLAMADLEQKVHE---------MEASTFDGVFIWKISDFT--RKRQEAVAGRT-- PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHVSLFFVVMKGPNDALLRWPFNQK--- VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VSD--M NI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- ------------------------------ >T_rubripes_ENSTRUP00000011363 -----------------------------SQ----------------------------- -----EPSPPSSLEGNKPGFPKKILANNLENKHLCKSCQKVLRRPLQAQ----------- --------------CGHRFCSFCFHKIV-------S-A--GPQTCS---ACISED-LFEE PASILK-LGG--AFPDNAARREVEALAAVCPNEG--CIWTGTIKEFE------------- -------------------------------------ARH--E-DSCDFM-IILCP---- ---SCKELMRVNEQER----HNERECPERTLNCKYCKDPFQLKNI-K--AHD-------- ---------------------------------------------E-ICPKYPMICEG-- -CSK--KKIPRE-------KYVDHIK-YCSKFK--------SPCRFHVVGCNTS---VEK EKIHDHERQCS---YEHLNLLL--HFIMGIKISLESLPPQSLDVASHKLLELHQSL-RDL ELKLQS---------------------EKTK---VAELS-------RRCQDLELKVRTFE NIVCV-------LNREV-------------------------ERSCTTMEAYNRQHRLD- -------------QDKIEILNNK--------------------------VRQL-----ER TVSLRDLSIVEIDEKMRE---------LSAATYDGVFVWKISDFT--KKRQDAVAGRA-- PAMFSSAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMRGHSDALLKWPFNQK--- VTLMLLDQNNR-------EHIIDAFRPD--ISSSS---FQRP------------VSD--M NI-ASGCPLFCPLPKLD-CKN-SYIRDDTIFI---KVIVD-LTGL--------------- ------------------------------ >B_taurus_ENSBTAP00000013869 -------------------MA--------AA----------------------------- -----SVTPPGSLDLLQPGFSKTLLGTKLEDKYLCSACKNVLRRPFQAQ----------- --------------CGHRYCSFCLSSIL-------S-S--GPQSCA---ACVHEG-IYEE GVSILE-SSS--AFPDNAARREVESLPAVCPSEG--CSWKGTLKDYE------------- -------------------------------------SCH--E-GQCPFM-LTECP---- ---ACKGLVRLGEKEH----HLEHQCPERSLSCRHCRAPCSPADM-K--AHH-------- ---------------------------------------------Q-ICPKFPLTCDG-- -CGK--KKIARE-------KFQDHVR-ACGRCR--------VPCRFHAVGCPEM---VES EQQPEHEAQRL---QEHLALLL--GVLLEAGRPPGDS----------------------- --------------------------RLLLR---VAELL-------QRCEALERKTATFE NIVCV-------LNREV-------------------------ERVAVTAEACGRQHRLD- -------------QDRIEALSNK--------------------------VQQL-----ER SIGLKDLAMADLEQKVLE---------MEASTFDGVFIWKISDFS--RKRQEAVAGRT-- PAIFSPAFYTSRYGYKMCLRAYLNGDGTGR-GTHLSLFFVLMRGPHDALLRWPFNQK--- VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VGD--M NI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- ------------------------------ >M_mulatta_ENSMMUP00000015132 -------------------MA--------AA----------------------------- -----SVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACGNVLRRPFQAQ----------- --------------CGHRYCSFCLASIL-------S-S--GPQNCA---ACVHEG-IYEE GISILE-SSS--AFPDNAARREVESLPAVCPIDG--CTWKGTLKEYEVKMPVCGTVTEPA VGSRPRSPSGRDLVLHVLTGAEACLMSVEEETELLLRSCH--E-GRCPLM-LTECP---- ---ACKGLVRLGEKER----HLEHECPERSLSCRHCRAPCCGADG-K--AHH-------- ---------------------------------------------E-VCPKFPLTCDG-- -CGK--KKIPRE-------KFQDHVK-TCGKCR--------IPCRFHAIGCLET---VEG EKQQEHEAQWL---REHLAMLL--SSVLEAKPLLGDQ----------------------- ----------------------------SHA---GSELL-------QRCENLEKKTATFE NIVCV-------LNREV-------------------------ERVAMTAEACSRQHRLD- -------------QDKIEALSNK--------------------------VQQL-----ER SIGLKDLAMADLEQKVLE---------MEASTYDGVFIWKISDFA--RKRQEAVAGRT-- PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VND--M NI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- ------------------------------ >O_anatinus_ENSOANP00000001757 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AFSDAAINKEISELNVHCVTPG--CSWTGLMKNFE------------- ------------------------------------PQDH--Q-AECDCA-LIPCHA--- ---GCGLMIMRKKLPD----HLENGCAKSPTTCLKCKQTFCSMEY--------------- ------------------------------------------------------------ -------------------QFNSPGS-TASRIQ--------DGCPFSVIGCSFM--HGSR EKVKEHETSSM---DMHLGLLL--QAVSQTKANQGDCEEEL------------------- ----------------------------------ALQRFMRE----KLISDLEEKLHVFE NIVAV-------LNKEV-------------------------ESSNMAIAASIHQSNLD- -------------RDMILRLEQR--------------------------VLDL-----HQ TLAQKDLALARLKQSLQF---------SELASYDGIYLWKITDFS--RKCHESLCGRT-- TSLFSPVFYTARYGYKVCLRVYLNGDGTGK-GTHISLFFVIMKGEYDSLLQWPFRNK--- VTFMLLDQNNR-------EHVIDAFRPD--LNSAS---FQKP------------QGE--M NV-ASGCPMFFPLNKLQSPKH-AYVKDDTLFL---KCIIE-TNS---------------- ------------------------------ >X_tropicalis_ENSXETP00000008559 -------------------AA--------AV----------------------------- -----SGSPQGSLDLNQPGFKKEILGTKLEVKYLCSDCKNLLRRPLQAQ----------- --------------CGHRYCSHCLNKII-------S-T--GPQKCS---ACIQEG-IWHQ TVCIVS-DWG--GQPGNV--RGVGGGSSVILGGGMYCVLNPTHQSGR------------- -------------------------------------YCY--S-LGTCTA-LTHCV---- ---LCPGYPWNYSGDL----HSERECPERKLNCRYCKLSFYFPDI-K--AHD-------- ---------------------------------------------E-ICPKFPMTCEG-- -CGR--KKIPRE-------KFPDHVK-ICGRCK--------VPCRYAAVGCTEM---VEN DKCLEHENKSL---AEHLAKGS--PAPPANAPPNNSAK---------------------- ----------------------------------VAEML-------LKFDTLDKKNTTFE NIVSV-------LNREV-------------------------ERSSHAAEELARQLRAA- -------------QEKVEALTTK--------------------------VRQL-----ER TLGQKELIVAELETRMQE---------SELSTYDGVFIWKISEFG--KKRQDAINGRC-- PAMFSPPFYTNKYGYKMCLRIYLNGDGTGR-NTHLSLFFVVMKGNNDALLRWPFNQK--- VTLMLLDQNNR-------EHVIDAFRPD--VSSSS---FQRP------------ISE--M NI-ASGCPLFCQVSKLE-GKN-SYVRDDTIFV---KVIVD-LTGL--------------- ------------------------------ >C_familiaris_ENSCAFP00000028895 -------------------MA--------AA----------------------------- -----SVTPPGSLDLLQPGFSKTLLGTKPEDKYLCSACRNVLRRPFQAQ----------- --------------CGHRYCSYCLSSIL-------S-S--GPQNCA---ACVHEG-IYEE GISILE-SSS--AFPDNAARREVESLPAVCPNNG--CTWKGTLKEYE------------- -------------------------------------SCH--E-GHCPFM-LTECP---- ---ACKGLVRLGEKEH----HSEHECPERSLSCRHCRAPCCWADL-K--AHH-------- ---------------------------------------------E-VCPKFPLTCDG-- -CGK--KKISRE-------KFQDHVR-ACGKCR--------VPCRFHVVGCPEM---VES EKQQQHEAHWL---REHLAMLL--GSLLEAKHLSGAG----------------------- ---------------------------GPFL---GLKLQ-------QRCEALERKTATFE NIVCV-------LNREV-------------------------ERVAMTAEACGRQHQLD- -------------QDRIEALSNK--------------------------VQQL-----ER TIGLKDLAMAELEQKVHE---------MEASTFDGVFIWKISDFA--RKRQEAVAGRT-- PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- VTLMLLDQNNR-------EHVIDAFRPD--VTSSS---FQRP------------VSD--M NI-ASGCPLFCPVSKME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- ------------------------------ >O_latipes_ENSORLP00000003220 -------------------MA--------AL----------------------------- -----EPSPPSSMESNKPGFPKKILGNKLEDKHLCNCCHNILRRPIQAQ----------- --------------CGHRFCSYCFNRTV-------S-N--GPQKCN---ACIKEE-IFEE PTSILK-QGC--AFPDNAVRREVEGLSADCINEN--CPWKGTIKEYE------------- -------------------------------------LDH--E-GKCEFM-IIPCP---- ---SCKERIRFSEQER----HSERECPERTLNCKYCKEPFHFKNI-K--AHD-------- ---------------------------------------------E-ICPKYPMICEG-- -CAK--KKIPRE-------KYVDHIK-FCSKFR--------TPCRFHVVGCDMS---VEK EKIHDHERAFA---YEHLNLLL--HYIMGMKVSMEGLQPQGLETAGHKLVELQKSL-RDL EARVSQLSTTSSG--------------PPVQ---GAAAS-------SSSSRLEVKSGTFE NVVCV-------LNREV-------------------------ERFTTTMEASNRQHKLD- -------------QDKIEALSNK--------------------------VRQL-----ER TVGLKDLTVAEMEGRLRE---------MAATTFDGVFIWRISDFA--KKRQDAVAGRA-- PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMRGLSDALLKWPFNQK--- VTLMLLDQSNR-------EHIIDAFRPD--VTSSS---FQRP------------VSE--M NI-ASGCPLFCPLSKLD-AKN-SYIRDDTIFI---KAIVD-LTGL--------------- ------------------------------ >D_rerio_ENSDARP00000043465 -----------------------------AQ----------------------------- -----EPSPPSSLEGNKPGFPKKILANKLEDKHLCNICLKILRRPFQAQ----------- --------------CGHRFCSYCFNKAV-------S-K--DKKVCT---TVV-------- --IMKK-KKK--AFPDNAAKREVEALEAVCINEE--CSWTGTIKEYE------------- -------------------------------------ANH--E-GKCDFR-ILPCP---- ---SCKELLRANELER----HNERECPERTLNCKYCKEPFHFKNI-K--AHD-------- ---------------------------------------------E-ICPKYPMICEG-- -CAK--KKIPRE-------KYVDHIK-LCTKFR--------TPCRFHVVGCDMT---VEK EKIHDHEQACS---YEHLNLLL--HFIMGIKVNLESLQPQSLELASHKIHELHQSL-REL EL--------------------------------------------KMGQELELKVNTFE NIVCV-------LNREM-------------------------ERSATTMEAYNRQHRLD- -------------QDKIEILNNKIESNQGIKCEADNSCFSPRNYWMFVQVRQL-----ER TVGLRDLSIVEMEAKMRE---------MSAATYDGVFVWKISDFS--KKRQDAVAGRA-- PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMRGHSDALLKWPFNQK--- VTLMLLDQNNR-------EHIIDAFRPD--ISSSS---FQRP------------VSD--M NI-ASGCPLFCPLSKLD-SKN-SYIRDDTIFI---KAIVD-LTGL--------------- ------------------------------ >G_aculeatus_ENSGACP00000022084 -----------------------------MA----------------------------- -----RISLDCP--VSLPGIPLSVLSVPMENKYKCQQCLLVLRKPVQAQ----------- --------------CGHRFCVHCFRQLT-------S-Y--GPKPCD---ACRQEE-IYEE PISILN-SNE--AFPDNAAGREIASLPAKCLNQG--CDWTGSIKEYE------------- -------------------------------------AQH--E-GRCELE-RMQCE---- ---ACKMSVLCTDKDR----HNERECEERTLNCKYCKMTFNFKEI-K--AHD-------- ---------------------------------------------E-ICLKFPLQCKD-- -CGK--KKIPRE-------KFNDHSK-SCAKSK--------SSCPFNDVGCKYM---MEN GKLGDHEHSSA---VEHLRLLL--PLVLS-SVSLAGGDAAG-ELQEDSGLGLYRAPEEGV ---------------------------ATGA---GAAAS-------ALSLDMEKKVNALE NIVCV-------LNREV-------------------------GRNSVTLEAFSHQHRLD- -------------QEKIENLSNK--------------------------LLQL-----ER TVSMKDLQLSATDQLLKE---------LQFCTYDGIFVWKISDFS--RRRQDAVAGRT-- PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFFVVMRGKCDALLKWPFSQK--- VTLMLLDQNNR-------EHIIDAFRPD--VTSTS---FQRP------------ISE--M NI-ASGCPLFCPLAKLA-GKS-PYLRDDTIFI---KAIVD-LTGL--------------- ------------------------------ >T_rubripes_ENSTRUP00000015632 ----------------TDAMA--------TQ----------------------------- -----EPSPPSSMESNKPGFPKKILGNKLEDKHLCNCCHNILRRPFQAQ----------- --------------CGHRFCSYCFNRTV-------S-N--GPQKCS---ACIKRI-LWFQ ------------AFPDNAVRREVEHLPAACINEN--CTWKGTIKEYE------------- -------------------------------------LNH--E-GKCEFM-IISCP---- ---SCKEHIRFNEQER----HNERECPERTLNCKYCKEPFHFKNI-K--AHD-------- ---------------------------------------------E-ICPKYPMICEG-- -CAK--KKIPRE-------KYVDHIK-FCSKFR--------TPCRFHVVGCDMS---VEK EKIHDHERAYA---YEHLNLLL--HYIMGMKVSMEGLQPQGLEVAGQKLVELQQSL-REL ELSVSTSFTPLPSSVGAALELQLHS--EKTK---VAELG-------RRCTELEVKANTFE NVVCV-------LNREV-------------------------ERFATTMEASNRQHKLD- -------------QDKIEALSNK--------------------------VRQL-----ER TVGLKDLTVAEMEGRLRE---------MSATTFDGVFVWRISDFA--KKRQDAIAGRA-- PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFFVVMRGQSDALLKWPFNQK--- VTLMLLDQSNR-------EHIIDAFRPD--VTSSS---FQRP------------VSE--M NI-ASGCPLFCPLSKLD-GKN-SYIRDDTIFI---KAIVD-LTGL--------------- ------------------------------ >C_elegans_F45G2.6 ------------------------------------------------------------ ----------------MTSQS-VMFKGGLPADCTCPICEQALRDPIKLN----------- --------------CDHHYCRQCFENEN------------RTPGCA---ACQT------- ---IIQ-PEL--CQHDRAKQKQILALPVVCTFESSGCPWDGQLGTLH------------- --------------------------------------DH--L-SECTFKSSLKCE---- ---KCGRQFAKNDLEK----H-RAKCELNRAVCSFCNKTIRDSDR-E--RHP-------- ----------------------------------------------KTCPQVIISCPF-- QCGL--TDRPRL-------EIEAHCP-SCPNVD--------NVCPFVPYGCTFA---GGK ESIQQHLSDEP---VRHLMYLC--DEITDLKGTYELMERD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MG SFNDRQTRILSAAETCTE-------------MFGPQLIWKIDKLQ--QRTNEAKSGAD-- TTIFSVPFMSHRFGYKMMACACLFGDGSSA-GKSISLYVLLLKGEFDPTLEWPFHRA--- IKISLLDQNPRPEDRVNITYVIDPRKLK--ANEKF---LARP------------RGE--R NA-AFGSQSFCSLAILQ-----NYVKDDKIYV---QIDVDRCETLPVQLKSRDAKERKQM LDAMRAKTPDVRLHQVRPVTSQSSSAELRV >D_rerio_ENSDARP00000091948 --------------------SGS------------------------------------- -----ASDPSLNGVSSTPGFPQSICDEVPKDKYLCSNCNNVLNKARQTV----------- --------------CGHRYCLACVNWLV-------RNN--KDLVCT---KCKGEDSNVES DTSVLT-PNQ--FFNDVAINKEILDLKVHCANQG--CPWRSTLKNFE------------- -------------------------------------QDH--Q-SQCEYA-LIPCNI--- ---GCGIMVQRKTLAT----HLESGCPNNKTACPSCTSVLTPREL-Q--V---------- -----------------------------------------------LLKKEKHVCPS-- -SGDKKTAKTDK-------KQKNNQP-ANSKKK--------EPCIFSDVGCPFK---GNP DKVKEHESCSH---AGHLQLLL--DVTRALQRTL-----NSATERVYQDSPVFLEPGPNG SSL----APQADGDIETD-----GGDPGVEL---A-----AG----QQLDALQQKVQVIE NIISA-------LNREV-------------------------EKTQISVVAMNRDHCNS- -------------QQIIQHLEAT--------------------------VAEL-----QQ RLVRKDILISSLQQSISA---------QQDVSYDGTFYWRVCDVS--QKQREAANSQK-- ISQYSPAFYTARYGFKVCLRLYLNGDGAGK-GSHISLFFVIMKGEYDPILSWPFKHK--- VTFFLLDQNQR-------EHVIDAFRPD--LSSMS---FHQP------------VSD--M NV-ASGCPLFFPLKKLRSPKH-AYCKDDTIYI---KCVVD-TSS---------------- ------------------------------ >A_carolinensis_ENSACAP00000005007 ----------------MSLLHSNTSFETNSQESGCCAAM-ASACSAAAKEE--SINASVS NE--TGGTLSNSFMEETQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKACIVKSI----------RDAGHKCP---IDNE------- ---ILL-ETQ--LFPDNFAKREILSLTVKCPNKG--CDQKMELRHLE------------- --------------------------------------DH--Q-QHCGFA-SEKCP---- ---QCQGIFQKNRLQE----HIKLECPRRQVSCPNCALLMPYEDK-E--VHD-------- ----------------------------------------------GVCLLANVCCEY-- -CN---TVLIRE-------QLPNHYDNDCPTAP--------VPCTYSDFGCPEK---MQR NELARHWQEFT---QVHMRMMA--QTLRNVHVTNPAS---GN---F-------------- -----------HAMPPS------CE------------CS-------PEVRNFKETIQQLE GRLVRQDHQ--------------------------------------------------- ----------------IRELIAK--------------------------METQ-----NS QVGDLKGTIKNLEEKITE---------LEAQQCNGIFIWKIEHFS--VYLKALEEERP-- VVIHSPGFYTGKPGYKLCMRLHIQLPNVQRCANYISLFVHIMQGEYDNYLPWPFQGT--- IRLSVLDQSEGSP----RQNHEEVMDTK--PELLA---FQRP------------KTR--R NPKGFGYVTFMQLQTLRQR---TYIKEDTVLV---RCEVLTRLDVM-------------- -----SPRREG--FQPRSTDGTV------- >E_caballus_ENSECAP00000009372 ----------------MASGSAS------------------------------------- -----SPRPAPDENEFPFGCPPTVCEDPSEPRALC------------------------- -------------------CAACLSENS-------RNG--EDRVCL---KCRGDDSQSVG PGSLVS-QEK--VHSD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AVAEAG--------VGCPFAGVGCSFK---GSP KFMQEHEVASQ---ATHLNLVL--GFMKQWKAQLGSGLGSG-----------PMALEQNL SDLQLQAAVEVAGDLEVDCYRAPCSESQEEL---ALQHFMKE----KLLAELEGKLRVFE NIVAV-------LNKEV-------------------------EASHLALAASIHQSQLD- -------------REHILSLEQR--------------------------VLEL-----QQ TLAQKDQALGKLEQSLRL---------MEEASFDGTFLWKITNVT--RRCHESACGRT-- VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFIVIMRGEYDALLPWPFRNK--- VTFMLIDQNNR-------EHAIDAFRPD--LNSAS---FQRP------------QSE--T NV-ASGCPLFFPLSRLQSPKH-AYVKDDTMFL---KCIVE-TSA---------------- ------------------------------ >G_aculeatus_ENSGACP00000020860 -------------------MA--------TQ----------------------------- -----EPSPPSSMESNKPGFPKKILGNQLEDKHLCNCCHNILRRPFQAQ----------- --------------CGHRFCSYCFNRTV-------S-N--GPQKCS---ACIKED-LFED PTSILK-PGC--AFPDNAVRREVENLSAVCIHEH--CSWKGSIKDYE------------- -------------------------------------LTH--E-GKCEFM-IIPCP---- ---SCKERIRFNEQER----HNERECPERTLNCKYCKEPFHFKNI-K--AHD-------- ---------------------------------------------E-ICPKYPMICEG-- -CAK--KKIPRE-------KYVDHIK-FCSKFR--------TPCRFHVVGCDMS---VEK EKIHDHERAFA---YEHLNLLL--HYIMGMKVSMEGLQPQGLELAGHKLLELQQAL-REL EARVSQLSTTSSG--------------PPVQ-----------------CTELEVKAGTFE NVVCV-------LNREV-------------------------ERFATAMEASNRQHKLD- -------------QDKIEALSNK--------------------------VRQL-----ER TVGLKDLTVAEMEGRLRE---------MSATTFDGVFVWRISDFA--KKRQDAIAGRA-- PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFFVVMRGLSDALLKWPFNQK--- VTLMLLDQSNR-------EHIIDAFRPD--VTSSS---FQRP------------LER--- -------P--CSLC------------------------------F--------------- ------------------------------ >D_rerio_ENSDARP00000036715 -------MACND-VDKSSFDDVCCD----SGHSSCA-AA-MEKERESFLSP--T---ENP STI----SVSSSMPPDQQGYD-VEFDPPLESKYECPICLMGLRSAVQTP----------- --------------CGHRFCDSCIRKSI----------RDTGQKCP---VDNE------- ---VLL-EEQ--LFPDNFAKREILSLTVKCSNFG--CSEKMELRQLE------------- --------------------------------------KH--L-SQCRFA-TAPCP---- ---QCQESVPISHLDE----HKSQHCLQRIMTCPDCAGSFVYAVK-Q--NHE-------- ----------------------------------------------QFCPFANTVCEY-- -CE---MELIRD-------QLALHCDTDCLKAP--------VACTFSTFGCREK---MTR NELAQHMQEFT---QMHMRYMA--EFLRSQTLNNCTMPSA------------AAHLS--- ------SDDRGASARSP------DSCQ----------CK-------QELLNLRETVLELE GRLVRQDQQ--------------------------------------------------- ----------------IRELCIH--------------------------NDTQ-----KN QVTELRRKLVSLEESTRE---------LEAQQYQGIYVWRVENFS--HHLRNQEAGQP-- IVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVHTMQGEFDSQLSWPLQGT--- IRLAVLDQ---VE----GQHHIEVMETK--PDLQA---FQRP------------TVM--R NPKGFGYVTFLHLQALRQR---GFVKEDVLLV---RCEVTPRFD-A-------------- -----SLRREG--VQPRGPEPSI------- >T_guttata_ENSTGUP00000002510 -------------------MA--------AA----------------------------- -----NSSPPGSLDLNQPGFAKEILGTKLEVKYLCSDCKNILRRPFQAQ----------- --------------CGHRYCSYCLKKII-------S-A--GPQKCA---SCIQEG-IYEE GISILE-TSS--AFPDNAARREVESLPAVCINSG--CNWKGTIKEYE------------- -------------------------------------VQA--K-ARLGTS-ASFFP---- ---LC-----LGKAQRVVCAHVGESCQIPGLYCQLEKFP-NVVHM-V--LHC-------- ---------------------------------------------E-ETPHCECSWRN-- -CEGIWKKHPGA-------AFRDHVK-TCGRSK--------VPCRFEAVGCAEV---VEN EKLPEHERKCL---AEHLYMLM--SSVLSLKTGAGDL----------------------- ------------------------------K---PLPLL-------GRCEALERKTVTFE NIVCV-------LNREV-------------------------ERVSLTAEAYSRQHRLD- -------------QEKIETLSNK--------------------------VRQL-----ER SIGLKDLAMAEMEEKIRN---------MEASTYDGVFIWKITEFA--RKRQEAITGRS-- PAIFSPAFYTSKYGYKMCLRVYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQK--- VTLMLLDQNNR-------EHIIDAFRPD--VTSSS---FQRP------------VTE--M NI-ASGCPLFCPVSVME-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- ------------------------------ >M_domestica_ENSMODP00000024498 ----------------LTDTAPV------------------------------------- -----GPHLIPDENEFPFGYPASICQGTPEPKYLCCGCHNVLKKAQQTL----------- --------------CGHRYCAACLSWIL----------------------------SSPN DGTLFF-WGF--FQNS-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------L-VPAEDQ--------DRCPFADIGCSFK---GGQ ERVKEHEASSL---SDHLRRLL--ELVIRTKVQAGPSRGRGASGRRQAAEPEPKAPERNL SDLQLQGAVEVNGDLEADYFHAASSDSEEEL---ALQRFMKE----KLLSELEEKLRVFE NIVTV-------LNKEV-------------------------EASHLAIAASVHQSGLT- -------------QDLILSLEQR--------------------------VVDL-----QQ TLTQKDLALTKLEQTLHL---------LEEASYDGVYLWKITNFT--RRCHESACGRT-- VSLFSPAFYTARYGYKLCLRIYLNGDGMGK-GTHLSLFIVVMKGKYDALLEWPFRNKAIP VTFMLLDQNNR-------EHVTDSFHPD--LTSGS---FQKP------------QGE--S NI-ASGRPMFFPLNKLQSSKH-AYVKDDTLFL---KCVIE-TNS---------------- ------------------------------ >T_guttata_ENSTGUP00000010462 ----------------MSLLHSDSSCGGRDAESGCCAAM-ASACSAAAKEE--S---SSV GS--AVGTAPGSFGEETQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKGCIVKSI----------RDAGHKCP---VDNE------- ---ILL-ENQ--LFPDNFAKREILSLMVKCPNKG--CSMKMELRHLE------------- --------------------------------------DH--Q-LQCDFS-TVECL---- ---QCQGTFPKNHLKE----HMTQECPRRQVCCPNCATSMAYEDK-E--LHD-------- ----------------------------------------------QTCPLANIYCEY-- -CN---TVLIRE-------QMPNHYDNDCPTAP--------VPCFYSAFGCPEK---MQR NELARHMQEFT---QVHMRMMA--QSFQNISVTAANP---VP---FINGLPFEPALF--- ------S----HVSHAA------YN------------CN-------PEVENFKETIQQLE GRLVRQDHQ--------------------------------------------------- ----------------IRELIAK--------------------------METQ-----NT HMAELKRTIRNLEGKITE---------MEAQQCNGIYIWKIENFS--GLQRAQEEERP-- VVLHSPGFYTGKPGYKLCLRLHIQLPNAQRCANFISLFVHTMQGEYDSHLPWPFQGT--- IRLSILDQSEGPE----RQNHEEVMEAK--PELLA---FQRP------------TIH--R NPKGFGYVTFMHLETLKQR---TFIKDDTLLV---RCEVLTRLDLS-------------- -----SVRREG--FQPRSTDGAM------- >O_anatinus_ENSOANP00000018657 ----------------MSLLNCENSCGASQSEGDCCAAM-ASACSAGAKDD--S---VSS SV--NTGNLHNSFMAETQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKACIVKSI----------RDAGHKCP---VDNE------- ---ILL-ENQ--LFPDNFAKREILSLMVRCPNEG--CLMKMELRQLE------------- --------------------------------------EH--Q-SLCDYA-LVECP---- ---QCHISFQKNILHD----HVVSECPRRQVSCVNCALSMAFEDK-E--YHD-------- ----------------------------------------------QNCPLASVFCEY-- -CS---TVLIRE-------QMPTHYDMDCPTAP--------IPCTFSSFGCREK---MQR NQLARHLQDDT---QAHMRMMA--QALHSISITALTP---VP---QLDVLPFDPA----- -----------SLPRSS------SGYD----------CH-------PEVQNFQETIQQLE GRLVRQDHQ--------------------------------------------------- ----------------IRELIAK--------------------------METQ-----SS HVVDLKRTIRTLEDKIAE---------MEAQQCNGIYIWKIGNFG--MHLKSQEEEKP-- VVIHSPGFYTGKPGYKLCMRLHLQLPNAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- IRLTILDQSEAPV----RQNHEEIMDTK--PELLA---FQRP------------TIH--R NPKGFGYVTFMHLQALRQR---AFIKDDTLLV---RCEVSTRFDMS-------------- -----SPRREG--FQPRSTDPGV------- >X_tropicalis_ENSXETP00000031605 -------------------IMACEDLC-PLPVTLG------------------------- -----RQNSSAAVSLDFVPKQEYLFVEQLQDRYKCASCHLVLHNPHQTG----------- --------------CGHRFCEKCISNLI-------ELS--ETPQCP---IDME------- ---NIK-SHE--IFKDNCCKREVLNLLVYCKN-SPACDVKVMLGRYQ------------- --------------------------------------EH--L-GQCLYE-MTLCSND-- ---GCHDQMIRKELKG----HLESECKLRQEACIYCKQTMASINL-T--IHV-------- ---------------------------------------------GLYCQLYPVPCPN-- ACP---VTCPRA-------ELDKHLC-ECPEAE--------LQCTFSNYGCNVM---VKR GKVKEHEDTFL---RDHMLYVL--NRNMKLEEQVLGLQQNL-DLKEHQIQQLSDTVKW-- ---------------------------CEKE---CHQFG-------QFTGSNGNSLSSTK -TLASYIDKSMWLEEQV--------------IQLVSKEHSRLDLRPILDTLESTKQRLS- TLEAY--------KDRIDNLDGQ--------------------------FKKH-----DV LLSNHKMQMTSNEERFRL---------VEGTSYNGKLIWKITDYE--RKKREAMEGRA-- VSIFSQHFYTSWCGYRLCARAYLNGDGSGK-GSFLSLYFVVMKGEFDSILLWPFKQK--- VTLMLLDQSGK------KNHITDVFRAD--PNSSS---FKRP------------DSE--M NI-ASGCPRFASHAQLENPKNGCYIK---------------------------------- ------------------------------ >H_sapiens_ENSP00000316840 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAVTKDD--S---VGG TA--STGNLSSSFMEEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE------- ---ILL-ENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------------- --------------------------------------DH--Q-AHCEFA-LMDCP---- ---QCQRPFQKFHINI----HILKDCPRRQVSCDNCAASMAFEDK-E--IHD-------- ----------------------------------------------QNCPLANVICEY-- -CN---TILIRE-------QMPNHYDLDCPTAP--------IPCTFSTFGCHEK---MQR NHLARHLQENT---QSHMRMLA--QAVHSLSV--------IP------------------ ----------------D------SG------------YI-------SEVRNFQETIHQLE GRLVRQDHQ--------------------------------------------------- ----------------IRELTAK--------------------------METQ-----SM YVSELKRTIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKCQEEEKP-- VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- IRLTILDQSEAPV----RQNHEEIMDAK--PELLA---FQRP------------TIP--R NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- -----SLRREG--FQPRSTDAGV------- >P_pygmaeus_ENSPPYP00000003845 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGG TA--STGNLSSSFMEEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE------- ---ILL-ENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------------- --------------------------------------DH--Q-AHCEFA-LMDCP---- ---QCQRPFQKFHINI----HILKDCPRRQVSCDNCAASMAFEDK-E--IHD-------- ----------------------------------------------QNCPLANVICEY-- -CN---TILIRE-------QMPNHYDLDCPTAP--------IPCTFSTFGCHEK---MQR NHLARHLQENT---QSHMRMLA--QAVHSLSL--------IP------------------ ----------------D------SG------------YI-------SEVRNFQETIHQLE GRLVRQDHQ--------------------------------------------------- ----------------IRELTAK--------------------------METQ-----SM YVSELKRTIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKCQEEEKP-- VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- IRLTILDQSEAPV----RQNHEEIMDAK--PELLA---FQRP------------TIP--R NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- -----SLRREG--FQPRSTDAGV------- >P_troglodytes_ENSPTRP00000006096 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGG TA--STGNLSSSFMEEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE------- ---ILL-ENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------------- --------------------------------------DH--Q-AHCEFA-LMDCP---- ---QCQRPFQKFHINI----HILKDCPRRQVSCDNCAASMAFEDK-E--IHD-------- ----------------------------------------------QNCPLANVICEY-- -CN---TILIRE-------QMPNHYDLDCPTAP--------IPCTFSTFGCHEK---MQR NHLARHLQENT---QSHMRMLA--QAVHSLSL--------IP------------------ ----------------D------SG------------YI-------SEVRNFQETIHQLE GRLVRQDHQ--------------------------------------------------- ----------------IRELTAK--------------------------METQ-----SM YVSELKRTIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKCQEEEKP-- VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- IRLTILDQSEAPV----RQNHEEIMDAK--PELLA---FQRP------------TIP--R NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- -----SLRREG--FQPRSTDAGV------- >T_nigroviridis_ENSTNIP00000012472 -------MACFDSSSKGSLEEDSCDGAIGGELSGCALVM-MEKEQESLLSP--S---ESP GTYMSGASSSFHDGTHQQGYD-VEFDPPLESKYECPICLMALRNAIQTP----------- --------------CGHRFCKNCIEKSI----------RDAGQRCP---VDNE------- ---MLS-KEQ--LFPDNFAKREILSLIVRCSNPG--CTSKMELRHLE------------- --------------------------------------NH--L-ASCEFA-TVPCP---- ---HCQQSVKKTLLEE----HTSVQCRRRPVSCPDCVEIFVYEEK-E--RHE-------- ----------------------------------------------QQCPFASVMCPH-- -CD---MDLTRD-------QMESHCDTDCPKAP--------IACNFSLFGCKER---MQR HDLARHMQDFT---QMHMHYMA--DFLRSLNLNGTIPKDQGA----------AASAS--- ------SCSKGALSSNC------TPCQ----------PT-------EEMQRLR----EMD RRLVKQDHQ--------------------------------------------------- ----------------LRELIIL--------------------------KENQ-----TG QIAELRKRVSVLEESMRE---------LESQHCTGIYIWRLKDFS--VLLRNQEAGLP-- VVEHSPGFYTGRPGYKLCLRLHLQSPVAQRCSNFISLFVHTMQGAYDGLLTWPFQGT--- IRLAILDQ--GPE----GQHHIEVMETK--PDLQA---FQRP------------TII--R NPKGFGYVTFLHLHHLKER---AYVKDDALLI---RCEVTPRFD-N-------------- -----MLHRDGVTVQPRGSEASI------- >M_mulatta_ENSMMUP00000021907 MYILKERIRASDNQVTMSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGG TA--STGNLSSSFMEDIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE------- ---ILL-ENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------------- --------------------------------------DH--Q-AHCEFA-LVDCP---- ---QCQRPFQKFHINI----HILKDCPRRQVSCDNCAALVAFEDK-E--IHD-------- ----------------------------------------------QNCPLANVICEY-- -CN---TILIRE-------QMPNHYDLDCPTAP--------IPCTFSTFGCHEK---MQR NHLARHLQENT---QSHMRMLA--QAVHSLSL--------IP------------------ ----------------D------SG------------YV-------SEVRNFQETIHQLE GRLVRQDHQ--------------------------------------------------- ----------------IRELTAK--------------------------METQ-----ST YVSELKRTIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKCQEEEKP-- VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- IRLTILDQSEAPV----RQNHEEIMDAK--PDLLA---FQRP------------TIP--R NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- -----SLRREG--FQPRSTDSGV------- >B_taurus_ENSBTAP00000021630 ----------------MSLLHCENSCGSSQSESDCCAAMAASSCGTAAKDD--S---VSG TA--STVTLSSSFMEEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE------- ---ILL-ENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------------- --------------------------------------EH--Q-AHCEFA-LMSCP---- ---QCQRPFQKCHLNI----HILKECPRRQVPCENCAVSMAFEDK-E--IHE-------- ----------------------------------------------QNCPLANVICEY-- -CN---TMLIRE-------QMPNHYDLDCPTAP--------VPCTFSAFGCHEK---MQR NHLARHLQENT---QSHMRMMA--QAVQTLSL-AVAP---VP---QCTMPLYDSV----- -----------PPTRPS------SG------------RH-------SEVHNFQETIQQLE GRLVRQDHQ--------------------------------------------------- ----------------IRELTAK--------------------------METQ-----SM YVNELKRTIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKSQEEEKP-- VVIHSPGFYTGKPGYKLCMRLHLQLPSAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- IRLTILDQSEAAV----RQNHEEIMDAK--PELLA---FQRP------------TIP--R NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- -----SLRREG--FQPRSTDSGI------- >C_familiaris_ENSCAFP00000010159 ----------------MSLLNCENSCGSSQSESDCCPAM-ASSCSAAVKDD--S---VSG TT--STGNLSSSFMEEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE------- ---ILL-ENQ--LFPDNFAKREILSLMVKCPNEG--CLHKMELRHLE------------- --------------------------------------DH--Q-LHCEFA-LMNCL---- ---QCQRTFQKCQLNI----HILKECPRRQVSCMNCAALMAFEDK-E--IHD-------- ----------------------------------------------QNCPLANVICEY-- -CN---TMLIRE-------QMPNHYDLDCPTAP--------IPCTFSTFGCHVK---MQR NHLARHLQENT---QSHMRMLG--QAVQSLSL-ALAP---VP---QRDVPPYDSS----- -----------SVSRVS------ST------------CH-------PEVQNFQETIQQLE GRLVRQDHQ--------------------------------------------------- ----------------IRELTAK--------------------------METQ-----SM HVSELKRNIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKSQEEEKP-- VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- IRLAILDQSEAPV----RQNHEEIMDAK--PELLA---FQRP------------TIP--R NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- -----SPRREG--FQPRSTDSGI------- >M_domestica_ENSMODP00000024756 ----------------MSLLNCEDSCGTSHPESDCCAGV-ASACSTGTKDD--S---VNG ST--IPGNLPSSLREEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKACIVKSI----------RDAGHKCP---VDNA------- ---ILL-ETQ--LFPDNFAKREILSLTVKCPNEG--CLLKMELRHLE------------- --------------------------------------DH--Q-THCEFA-LAECP---- ---QCHLPFRKYLLHN----HMVVECPRRQVSCVNCAAPMPFEEK-EAKFHD-------- ----------------------------------------------QNCPLATVFCEY-- -CS---TMLIRE-------QMPNHYDIDCPVAP--------IPCTFSTFGCREK---MPR NHLARHLQEDT---LAHMRMMA--QAIENISIAAFNPK--LH---QREASSYDTS----- -----------PLPRTP---------------------Y-------PGPQNFQETIQQLE SRLVIQDHQ--------------------------------------------------- ----------------IRELTAK--------------------------METQ-----SA CVGDLKRTIRTLEDRIAE---------MEAQQCNGIYIWKINNFG--MHLKSQEEEKP-- VVIHSPGFYTGKPGYKLCMRLHLQLPSAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- IRLTILDQSEAPV----RQNHEEIMDAK--PELLA---FQRP------------TIP--R NPKGFGYVTFMHLQALKQR---TFIKDDTLLV---RCEVLTRLDMN-------------- -----SLRREG--FQPRSTDAGV------- >R_norvegicus_ENSRNOP00000006148 ----------------MSLLNCENSCASSQSSSDCCAAM-ANSCSAAMKDD--S---VSG CV--STGNLSSSFMEEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKACITKSI----------RDAGHKCP---VDNE------- ---ILL-ENQ--LFPDNFAKREILSLTVKCPNKG--CVQKMELRHLE------------- --------------------------------------DH--Q-VHCEFA-LVICP---- ---QCQRFFQKCQINK----HIIEDCPRRQVSCVNCAVPMPYEEK-E--IHD-------- ----------------------------------------------QSCPLANIICEY-- -CG---TILIRE-------QMPNHYDLDCPTAP--------VPCTFSVFGCHEK---MQR NHLARHLQENT---QLHMRLLA--QAVHNVNL-SLRP---CD------------------ ------------ASSPS------RG------------CR-------PEDPNYEETVKQLE GRLVRQDHQ--------------------------------------------------- ----------------IRELTAK--------------------------METQ-----SM HVSELKRTIRSLEDKVAE---------MEAQQCNGIYIWKIGNFG--MHLKSQEEERP-- VVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- IRLTILDQSEAVI----RQNHEEVMDAK--PELLA---FQRP------------TIP--R NPKGFGYVTFMHLEALRQG---TFIKDDTLLV---RCEVSTRFDMG-------------- -----GLRKEG--FQPRSTDAGV------- >G_aculeatus_ENSGACP00000022648 -------MASAE-SGKGSLQEDSYEGPVGGELSGCALAM-MEKERESLLSP--S---ESP GTFISGSSASLQAPAPLQGYD-VEFDPPLESKYECPICLMALRNAIQTP----------- --------------CGHRFCKNCIEKSI----------RDTGQRCP---VDNE------- ---RLL-EDQ--LFPDNFAKREILSLTVRCPNSD--CADKMELRHLE------------- --------------------------------------NH--L-GRCQFA-TVPCS---- ---QCQQAVRKSRLEE----HQTAECQKRPVSCPDCVASFFYEER-K--LHQ-------- ----------------------------------------------QRCPFAIVKCLF-- -CD---LELIRD-------QIESHCDTDCPKAP--------IACNFSAFGCKES---MQR HNLAQHMQEFT---QMHMRYMA--EFLRGLSLNGTTPKSLWAPAPSAYPEDQGATAALAA VCSGPRGAPSSMSSNSC------APSQ----------PA-------EGMQRLR----EMD GRLVKQDHQ--------------------------------------------------- ----------------LRELIIL--------------------------KETQ-----AG QLAELRRRVSLLEDTVKE---------LESQQCHGIFIWRLRGFS--AHLRNQEAGQP-- VVEHSPGFYTGRPGYKLCLRLHLQTPNAPRCSNFISLFVHTMQGAFDGQLSWPFQGT--- IRLAILDQ--GPE----AQHHVEVMETK--PDLQA---FQKP------------LIQ--R NPKGFGYVTFLHLHQLTQR---AFVKDDTLLI---RCEVTPRFD-N-------------- -----VLHRDGPTVQPRGPEASVSRD---- >T_rubripes_ENSTRUP00000041697 -------MACFD-SSKESL-EDSFDGAAGGKLSGCALAM-SEKERESLLNP--S---ESP STYMSGASSSFQDATHQQGYD-VEFDPPLESKYECPICLMALRNAIQTP----------- --------------CGHRFCKICIEKSI----------RDAGQRCP---VDNE------- ---MLS-KEQ--LFPDNFAKREILSLTVRCSNPG--CTGKMELRHLE------------- --------------------------------------DH--L-AHCQFA-TVPCP---- ---HCQQSVRKTILEE----HMTAECRRRPVSCPDCIETFVYEER-E--RHE-------- ----------------------------------------------QQCPFASVMCPY-- -CD---MDLVRD-------QMESHCDTDCPIAP--------IACTFSLFGCKER---MQR HDLARHMQDFT---QMHMHYMA--DFLRGLNLNGTTPKPLGAIGHSISFEDHGASAS--- ------SCDKGVSSSNC------APCQ----------PN-------EETQRLR----EMD RRLVKQDHQ--------------------------------------------------- ----------------LRELIIL--------------------------KETQ-----AG QLAELGRRVSMLEETVRE---------LESQHCTGIFIWRLKDFS--VLLRNQEAGLP-- VVEHSPAFYTGRPGYKLCLRLHLQSPNAQRCSNFISLFVHTMQGAFDGRLTWPFQGT--- IRLAILDQ--GPE----GQHHVEVMETK--PDLQA---FQKP------------TII--R NPKGFGYVTFLHLQQLNQR---AYVKDDILLI---RCEVTPRFD-N-------------- -----MFHRDGITVQPRGPEASM------- >M_musculus_ENSMUSP00000004949 ----------------MSLLNCENSCGSSQSSSDCCAAM-AASCSAAVKDD--S---VSG SA--STGNLSSSFMEEIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE------- ---ILL-ENQ--LFPDNFAKREILSLTVKCPNKG--CLQKMELRHLE------------- --------------------------------------DH--Q-VHCEFA-LVNCP---- ---QCQRPFQKCQVNT----HIIEDCPRRQVSCVNCAVSMAYEEK-E--IHD-------- ----------------------------------------------QSCPLANIICEY-- -CG---TILIRE-------QMPNHYDLDCPTAP--------IPCTFSVFGCHEK---MQR NHLARHLQENT---QLHMRLLA--QAVHNVNL-ALRP---CD------------------ ------------AASPS------RG------------CR-------PEDPNYEETIKQLE SRLVRQDHQ--------------------------------------------------- ----------------IRELTAK--------------------------METQ-----SM YVGELKRTIRTLEDKVAE---------MEAQQCNGIYIWKIGNFG--MHLKSQEEERP-- VVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- IRLTILDQSEALI----RQNHEEVMDAK--PELLA---FQRP------------TIP--R NPKGFGYVTFMHLEALRQG---TFIKDDTLLV---RCEVSTRFDMG-------------- -----GLRKEG--FQPRSTDAGV------- >G_gallus_ENSGALP00000012873 ----------------MSLLHSDSSCGGRDLDSGCCTAM-ASACSGGAKED--S---VSV GS--GTGNPPSSFTEETQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKGCIVKSI-------RRCRDAGHKCP---VDNE------- ---ILL-ENQ--LFPDNFAKREILSLTVKCPNKG--CCLKMELRHLE------------- --------------------------------------EH--Q-LHCDFT-TVECP---- ---QCQGAFQKNHLKE----HMTQECPRRQVCCPNCATSMAYEDK-E--LHD-------- ----------------------------------------------QTCPLANVFCEY-- -CN---TMLIRQ-------QMPNHYDNDCPTAP--------VPCFYSAFGCPEK---MQR NELARHMQEFT---QVHMRMMA--QSIQNISVTATNP---VP---FINGLPFEPALF--- ------S----HVSRAP------YN------------CN-------PEVENFKETIQQLE GRLVRQDHQ--------------------------------------------------- ----------------IRELIAK--------------------------METQ-----NT HMAELKRTIRDLEGKITE---------MEAQQCNGIYIWKIENFS--GLQKAQEEERP-- VVMHSPGFYTGKPGYKLCLRLHIQLPSAQRCANFISLFVHTMQGEYDSHLPWPFQGT--- IRLSILDQSEGPE----RQNHEEVMEAK--PELLA---FQRP------------TIH--R NPKGFGYVTFMHLQTLKQR---TFVKDDTLLV---RCEVLTRLDLN-------------- -----SLRREG--FQARSTDGAA------- >A_carolinensis_ENSACAP00000006987 --------------------A--------SA----------------------------- -----NVTPPGSLDEDQVGFPKEILGTELEGKYLCSECGNILRRPFQAQ----------- --------------CGHRYCASCLQRLI-------S-S--GPQKCG---ACIQEG-IYED GVSILE-TGS--AFPDNAARREVESLPAICANEG--CAWKGTIKEYE------------- -------------------------------------SGH--G-GSCPWA-LATCP---- ---SCRGPVRRRDQER----HAARECPQRSLSCKFCKALCHFPQI-K--AHD-------- ---------------------------------------------E-VCPKFPLTCEG-- -CGK--RKIPRE-------KFPEHVK-SCSKCK--------APCRFQPIGCNVV---VSP SRWDE-AGPII---YKYC------------------------------------------ ------------------------------------------------------------ -IIHY-------SNWIW-------------------------GRVRVTLPSF-------- ----------------LPSLW-Q--------------------------VRQL-----ER SLASKDLALAEMEHSLQE---------MEAASFDGIFIWKISDFT--KKRQ-AVAGRS-- PAIFSPAFYTGKYGYKMCLRIYLNGDGTGR-GTHLSLFFVVMRGPCDALLRWPFNQK--- V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------ >X_tropicalis_ENSXETP00000016445 ----------------MSILNCRPSFDGVDTDDACCGAM-ASACCVNTKEDGES---PSA GS--PSGTPQSLVLEDVQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKACILKSI----------RDAGHKCP---VDNE------- ---SLM-ENQ--LFPDNFAKREILSLRVKCPSQG--CTETMELRHLE------------- --------------------------------------RH--L-VRCDFA-GVECS---- ---QCQSSFPKYSLQK----HMFEECPRRQIFCENCALAMALEDK-L--NHD-------- ----------------------------------------------QTCPLAYVTCEY-- -CQ---TNLIRE-------QMPAHYSMDCTMAP--------IPCMYYEFGCTEK---MQR NDLARHLQEFT---QAHMRMMA--QTLRSFSS-SVTPTSHMPDISFCDPSQFEPAPP--- ------SVATVHSSHTP------SQND----------CT-------QETRNLRETIEQLE GRLVRQDHQ--------------------------------------------------- ----------------IRELIAK--------------------------METQ-----CT YVNELKHTIRSLDNRLGE---------MESQQCSGIFIWRINNFN--SLLKNQEEERP-- VVIHSQGFYTGKPGYKLCLRLHLQLPSAQRCANYISLFVHTMQGEYDSLLPWPLQGT--- IRLSILDQSEGVA----MQDQEEVMDTK--PELLA---FQRP------------TVA--R NPKGFGYVTFMHLQALKQR---QYVKNDTLLV---RCSVTTHLDLI-------------- -----SPRREG--FQPRSGDGAL------- >E_caballus_ENSECAP00000018618 ----------------MSLLNCENSCGSSQTESDCCAAM-ASSCSAAAKDD--S---VSG TA--STGNLSSSFMEDIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKACIIKSI----------RDAGHKCP---PD-E------- ---ILY-HP-----ASSLTRRESL-LCPMCPHCM--CYPPSKLYHRS------------- --------------------------------------DH--Q-AHCEFA-LMNCP---- ---QCQHPFQKCQLNI----HMLKECPRRQVSCVNCAVSMAFEDK-EASIHD-------- ----------------------------------------------QNCPLANVICEY-- -CN---TMLIRE-------QMPNHYDLDCPTAP--------IPCTFNTFGCHEK---MQR NHLARHLQENT---QSHMRMLA--QAVQSLSL-ALAP---VP---QRDMLPYDSA----- -----------PLSRVS------SG------------CY-------PEVRNFQETIQQLE GRLVRQDHQ--------------------------------------------------- ----------------IRELTAK--------------------------METQ-----SI YVSELKRTIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKSQEEEKP-- VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- IRLTILDQSEAPI----RQNHEEIMDAK--PELLA---FQRP------------TIP--R NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- -----SLRREG--FQPRSTDTGV------- >O_cuniculus_ENSOCUP00000010330 ----------------MSLLNCENSCGSGQSESDCCAAM-ASSCSAAAKDD--S---VSG TA--STGNLSGSFVEDIQGYD-VEFDPPLESKYECPICLMALREAVQTP----------- --------------CGHRFCKACIIKSI----------RDAGHKCP---VDNE------- ---ILL-ENQ--LFPDNFAKREILSLTVKCPNEG--CLHKMELRHLE------------- ------------------------------------XXXX--X-XXXXXX-XXXXX---- ---XXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X--IHD-------- ----------------------------------------------QNCPLANVICEY-- -CN---TMLIRE-------QMPNHYDLDCPTAP--------IPCTFSTFGCHEK---MQR NHLARHLQEKT---QLHMRMLA--QAVHSLNL-ALTP---IP------------------ ----------------D------SG-------------Y-------PEGHNFQETIQQLE GRLVRQDHQ--------------------------------------------------- ----------------IRELTAK--------------------------METQ-----SM YVSELKRTIRTLEDKVAE---------IEAQQCNGIYIWKIGNFG--MHLKSQEEEKP-- VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGT--- IRLTILDQSEAPI----RQNHEEIMDAK--PELLA---FQRP------------TIP--R NPKGFGYVTFMHLEALRQR---TFIKDDTLLV---RCEVSTRFDMG-------------- -----SLRREG--FQPRSTDAGV------- >R_norvegicus_ENSRNOP00000058607 -------------------MA--------AA----------------------------- -----SVTSPGSLELLQPGFSKTLLGTRLEAKYLCSACRNILRRPFQAQ----------- --------------CGHRYCSFCLTSILRSQSAHSS-S--GPQNCA---ACVHEG-LYEE GISILE-SSS--AFPDNAARREVESLPAVCPNDG--CTWKGTLKEYE------------- -------------------------------------SCH--E-GLCPFL-LTECP---- ---ACKGLVRLSEKKH----HTEQECPKRSLSCQHCRAPCSHADL-E--LHY-------- ---------------------------------------------E-VCPKFPLTCDG-- -CG---KKISQE-------KLQDHVR-TCSKCR--------VLCRFHAIGCSEL---VET EDLQDHELQRL---REHLALLL--SSFLESQASQNQV----------------------- ----------------------------------GPELL-------QRCQILEQKIATFE NIVCV-------LNREV-------------------------ERVAVTAEACSRQHRLD- -------------QDKIEALSNK--------------------------VQQL-----ER SIGLKDLAMADLEQKVSE---------LEVSTYDGVFIWKISDFA--RKRQEAIAGRT-- PAIFSPGAVCVLRMLLMLLNVYLQGRGTGR-QTHLSQLSVCARAYWAVVLQWLLTEQ--- VTLMLLDHNNR-------EHVIDAFRPD--VTSSS---FQRP------------VSD--M NI-ASGCPLFCPVSKIE-AKN-SYVRDDAIFI---KAIVD-LTGL--------------- ------------------------------ >M_mulatta_ENSMMUP00000021905 -------------------LNCENGCGSSQSESDYCVAM-ASSCSAATKDD--S---VGG TA--SMGNLSSSFMEEIQGYD-VEFDPPLESRYECPICLTALREAVQTP----------- --------------CGHRFRKGCIIKSI----------RDAGHKCP---VDDE------- ---ILL-ENK--LFPDSFAKREILSLMVNCPNEG--CLHKMELRHLG------------- --------------------------------------DH--Q-AHCEFA-LMDCP---- ---QCQHPFQKFHINI----HILKDCPRRQVSCDNCAASMAFIKR-S--V-D-------- ----------------------------------------------QNCPLANVICEY-- -CN---TILIRE-------Q-ASYYDVDCPTAP--------IPCTFRTFDCHEK---MQR NHLSHHLQE-T---PCHTRMLT--QAVHSLSL--------IP------------------ ----------------D------SG------------YI-------SEARNFQETSHQLE DRLVGQDNQ--------------------------------------------------- ----------------IQELTDE--------------------------IETQ-----SI YVSE----IRTLEDKVAD---------IEAQQCNGIYIWKIGS-----HLKCQEEEKP-- VVIHSPGFYTGKPGYKLCMRLHLQLLTAQRCANYISLFVHTMQGEYDSHLPWPF-GT--- ICLTILDQSQAPV----RQNHEEIMDAK--PELLA---FQQP------------TYP--- NPKGFGYVTFIHLEALRQR---TFIKYDTLLV---RCEVSTCFDMG-------------- -----SLRREG--FQPQSTDAGI------- >O_latipes_ENSORLP00000001290 --------------------------ASGGGLSECASAM-LEKERESLPSP--S---DNP TA--SMGSSSLQAAAPLQGYD-VEFDPPLESKYECPICLMALRNAIQTR----------- --------------CGHRFCKSCIEKSI----------RDTGQRCP---VDNE------- ---MLS-EDQ--LFPDNFAKREILSLTVRCPNSD--CGEKMELRHLE------------- --------------------------------------KH--L-AQCQFA-TVPCS---- ---QCQQPVRKSYLEE----HATVECPRRPMSCPDCVAVFVYEER-E--MHE-------- ----------------------------------------------QQCPFASVMCQY-- -CE---MDLIRD-------QMESHCDTDCPKAP--------IACTFSIFGCKER---MQR HNLAQHMQEFT---QMHMRYMD--IRMTTLTKKTKTTKNALIVIYFFFPKICVFLVQLQ- ------HRLRGSSTRSAASQLILQSCEFTLYSHSKRLVK-------NCFYHLR-NVAKLK PMLTRSDLELIIDSVKC-----------------------------------FKAQGFPS LVKCQNILKTPKTQFSLEWVLRH--------------------------KDRKSNHKLAG QLAELRRRVSVLEETVKE---------LEAQQYHGIFIWRLKAFS--THLRSQEAGIP-- VVEHSPGFYTGRPGYKLCLRLHLQTPTAPRCSNFISLFVHTMQGVFDSQLTWPFQGT--- IRLAILDQ--GPE----GQHHMEVMETK--PDLQA---FQKP------------INQ--R NPKGFGYVTFMHRSLLSQR---AYVKDDTLLI---RCEV--------------------- ------------------------------ >C_elegans_Y110A7A.2 ------------------------------------------------------------ -----------------------------------------METPIMQ------------ ------------------------------------------------------------ ----------------EGVEKEITPRPIMVQPMG-------GMKPIK------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------SASNPPTPLDSPF-- MAGA--INRPRTSTRSVGVSIPIHVEGEEPTAPKSIVPDNWIDCPFKEHGCHKK---GEN SEVKRHVRDDR---NLHLVLLC--QSLNPIRTKINIQQ---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SA YVDKYVGMLQYM--SIAE---------SAFEKYGSQHTFRIPKIG--LTVVKATKNKS-H RSIYSQPFYSHGYGYKMMAVAAPYGDGLAF-REYFSVFVCLMKGEWDDILEWPFRCD--- VTFSILSDDKK-------ELLTKTIYVNEMPEIQE--FLERP------------EGL--R NG-TFGFQNFLPLAKVT-----EFAADGDIFI---QIKVLLSKEKQ-------------- -----KTQAKEVDSSECQSEMVGSSKAKSE >A_gambiae_AGAP003004-PA ------------------------------------------------------------ ---------------FLQSAA-KADDGVLEARYECPICYCWLNEPILTK----------- --------------CGHRFCRKCITDWL----------NEKNSNCP---LDNE------- ---PLDIKCD--IFPDNCTRREISQIKKPCPNSMRGCGEQLSPTDID------------- --------------------------------------TH--L-RQCPFA-MS------- --------------------RQSQPCPFARVKCKFVAPDEAAMS-----AHI-------- ---------------------------------------------ASDCQQHLQVARS-- PCVSA-LTVTKF-------EFSPFTI-----------------CSY----CSRR---GSN DRYKFWDPPA----KNSVPEMS-------------------------------------- ---------------------------------------------------TNELVRSM- ------------------------------------------------------------ -------------YERIVILEQE--------------------------VHIL-----GI KLSKQEIQLTKLNQ---E---------VDPRYSGGVLLWKLDDFS--NKIESMVANSN-- CMFYSSEAYTSPHGYKFCARINVS----PRTKDSIGLHVHLMQSENDYHLEWPFKGR--- IKITLLNVRSP------ELSQHDTIMSK--PEILA---FHRP------------NQD--I SPRGFGFLEFAKIKDILA----KFADNNTVVI---KIQMNIV------------------ ------------------------------