>D_melanogaster_FBpp0087167 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MYLPERTEHQKIERLYDSNRV-NAEP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GQGLDLNEK--LKPPAVYILNHEQFP-QDS-----------QLNRKGS-SNDVNAL -RKTFESLKCR-VEVISNPALPDVKNKVKEWSA-KRFT--QDAGFVLFILSHGDRK---- ---E-KILACDHRE-------------YHLDDDV-LFPLFRNPTLSGKPKILIVQ--ACK ----GPLR-----------------------------------------------A-DAK KMNNEPYIKCYSCSE--GYLSYRNENHGSVFIQTLCEAMDQYG-------LTRDFQSIFK HVKAEVERR-----------S--TMTG------SKQVPSEESHNFDKPFYFGNYAKNT-- -------------------------------------------------- >D_melanogaster_FBpp0085364 ------------------------------------------------------------ ------MGWWSKKSETDRSQPSQELVAQDPRTRVQTTSAATETTNTAVQNSTITDNNKQT VTFLTTRQTVTHTQRALITETTTRRTPSQAELEALFAKI--------------------- -------------------------KMGGEGPIGSTTTTTTTTSSRSRPPSLNGVSFRST QPFKATASNAGKRSSTLVKTEQTTVTQKNGRTVTQHLETHRVDLKGSRPKATWASFASTA NSSTSSYVSPYRQKPSMAITCTSPNIKTPKTTSSTSSSSASSITSPPKPSSSVSSISSIF KSAP-------------KQVDKPLSSTATPKPFISLGSSGGTKPKVTAVAQSQDAQGTIS TSLGISKSSLTKNK-LKPARVYIFNHERFDNK-------------NEFRKGS-AQDVKVL -RATFEQLKCK-VEVITDATLVTIKKTVRMLQT-KDFE--DKSALVLVILSHGTRH---- ---D-QIAAKDDD--------------YSLDDDV-VFPILRNRTLKDKPKLIFVQ--ACK ----GDCQ-LGGF-MT--------------------------------------DA-AQP NGSPNEILKCYSTYE--GFVSFR-TEDGTPFIQTLCEALNRSG-------KTSDIDTIMM NVRQVVKMQ----------------SK------DRQIPSV-TSTLTSKYVFGDYI----- -------------------------------------------------- >A_aegypti_AAEL005963-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSNKSSKTVTTLSHKQSTRSVTTSMTVSKSQTTS SGFVNSYGSPAVADRAFVPGSSSKTYEPVYE-KTRQLSRNTNTGSHTPKYQVPTQSA--- -----------------------TQSKDSNTAGGMFYSFQLTVDKKRSTSLENDVPALTV PNLG-----------------LTIAAAAPKIVTQD--------AQPSNARSNTPVSPGPV TLS-LEKYDL-----RKPAYVLIFHNIFK--NDK-----------KFHRKGS-EHDLKLI -KEFVKGYNMKIADICEDFSVTKVKKKMNKVSL-KNFG--SYSSLMIVIMSHGGLN---- ---D-QIQASNGF--------------YHLDTTI-VEPTLMNETLKGKPKLFFVQ--ACK ----GDAV----M-EA--------------------------------------DA-TQT ATNKFDILKCFSTYE--GTLSFRDTTEGTTFIQTLFKLIEQNS--------DKEIIDIMR LMRNIFCIN-----------K------------IAQAPTE-TSTLTKKFYFNDLKK---- -------------------------------------------------- >A_aegypti_AAEL005956-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSNKSSKTVTTLSHKQSTRSVITTMTVSKLQTTS SGFVNSYGSPAVADRAFVPGSSSKTYEPVYE-KTRQLSTITNTRSNTPKYQEPTKSA--- -----------------------SPSMVSKTAGNLFNSFGTADDKKRYTSLEINIPPKYV PSSS-------------WKSVTTTPTRSPNIVARD--------AQSSNARSNTPASPGPA TVS-LEKYDL-----RKPAYVLIFHNIFK--NNK-----------QLHRKGS-ELDLKLI -KEFVKGYNMKIADICEDFSVTKVKKKMNEVTL-KNFG--SYSSLMIVIMSHGGLN---- ---D-HIQTSNGF--------------YHLDTTI-VEPTLMNETLKGKPKLFFVQ--ACK ----GDAV----M-EA--------------------------------------DA-TRT ATNKFDILKCFSTYE--GTLSFRYTTEGTTFIQTLFKLIEQNS--------DKEIIDIMR LMRNIFCVN-----------K------------IAQAPTE-TSTLTKKFYFNDLKK---- -------------------------------------------------- >G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MSDT--TGDGRGGRVASPNKAATD -RAA-------------CTENLTETDALI--RSSL------------------------- -DP-AEEYKMDN---KRRGLALIFNQERFF-WRL--------G--LNDRHGT-NADRYNL -ERRLSNLNFD-VRAYDNLKQEEVLNKINEAAE-ENHS--DSDCFLLVFLSHGE-N---- ---D-QVYTYDG-K-------------ISVQDITSLFKGDKCKSLVGKPKIFILQ--ACR ----GDKH-DDPV-TAC---DAVDSE---LK------------T-NEVVVD-A-SV-LHT LPAGADFIMCYSVAE--GYYSHRETINGSWYIQDLCELLQRYG-------DSHEFTEVLT LVNRKVSMR---SVGNSS-DR--SAIG------KKQVPCF-ASMLTKKLYFRPKQ----- -------------------------------------------------- >G_gallus_ENSGALP00000019870 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MSGAERRPAAGRVQLDSKPTPT TTAD-------------GNQNITEVDAFDK-RQTF------------------------- -DP-AVQYKMNH---QRRGVALIFNHEHFF-WHL--------R--LPDRRGT-LADRNNL -KRSLTDLGFE-VRIFDDLKAEDVLKKVFEASR-DDYS--NADCFVCVFLSHGE-N---- ---D-HVYAYDA-Q-------------IKIETITNMFRGDKCQSLVGKPKIFIIQ--ACR ----GDKH-DDPV-LVQ---DSVDSK-DETT------------V-NQTEVD-A-AG-VYT LPAGADFIMCYSVAQ--GYFSHRETVNGSWYIQDLCEALGKHG-------SSLEFTELLT VVNRKVSHR---KVDICR-DI--NAIG------KKQIPCF-ASMLTKKLYFHPKSK---- -------------------------------------------------- >A_gambiae_AGAP010829-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------NAYVLVFHHDQF--KNP-----------KNNREGS-ANDMKQI -KEFCQHYRCDRLDINENKTKAEVTRKMGEISR-KDFT--KNSCLIVFIMSHGSAN---- ---D-TIMAKDGQF-------------YSFQDDV-VEYCTSNRTLNDKPKLFVLQ--ACR ----GDAT----M-VA--------------------------------------DA-TFS MSYKGDIIIFQSSYQ--GAVSFRDTESGSFFMQAFLRLAHEHN--------SESIVKINP LLNQEFTNK-----------K------------IRQTPTL-MTTLRKDLILRHLL----- -------------------------------------------------- >A_gambiae_AGAP010828-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------NAYVLVFHHDQF--KNP-----------KNNREGS-ANDMKQI -KEFCQHYRCDRLDINENKTKAEVTRKMGEISR-KDFT--KNSCLIVFIMSHGSAN---- ---D-TIMAKDGQF-------------YSFQDDV-VEYCTSNRTLNDKPKLFVLQ--ACR ----GDAT----M-VA--------------------------------------DA-TPS MSYKGDIIIFQSSYQ--GAVSFRDTESGSFFMQAFLRLAHEHN--------SESIVKINP LLNQEFTNK-----------K------------IRQTPTL-MTTLRKDLILRHLL----- -------------------------------------------------- >D_rerio_ENSDARP00000050929 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MASHTKSDGSAAVEKDSASAGQ T----------------VEENLTETDSFNQSIFSM------------------------- -DP-NQEYDMNH---KRRGMALIFNHENFF-WKL--------G--LGYRSGT-NADKENL -IRRFRELNFE-VKAFDDYKRHEVLSKITEAAA-ADHV--DADCFVCVFLSHGE-N---- ---G-HVYANDG-Q-------------IEIPEITDLFKGDKCRSLVGKPKIFIWQ--ACR ----GDKH-DDPV-TPM---DVVDSQV----------------T-NDMVVD-A-GV-LYT LPAGADFIMCYSVAE--GYYSHRETVNGSWYIQDLCEILRRYG-------SELEFAEILT LVNRKVSLR---SVLNCK-DR--SAVG------KKQVPCF-ASMLTKKLFFRPKK----- -------------------------------------------------- >T_guttata_ENSTGUP00000004278 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MSGSERRPPAGHVQLDSRPTLP -TTD-------------GNENITEVDALNI-RQSL------------------------- -DP-AEEYKMNH---QRRGLALIFNHERFY-WHL--------R--LQDRRGT-WVDRNNL -KSILTELGFE-VRLFDDLKKEDVQQRIYEAST-ADHS--NADCFVCVFLSHGE-D---- ---G-HIFAYDD-K-------------IEIQTITDMFRGDKCQSLVGKPKIFIIQ--ACR ----GDKH-DDAV-IAH---DSADG--SESP------------G-NETDVD-A-AG-VYT LPAGADFIMCYSVAQ--GYYSHRDTINGSWYIQDLCETLRKHG-------SSLEFAELLT VVNRKVSCR---RVGMCK-DI--NAIG------KKQIPCF-ASMLTKKLYFHPKSK---- -------------------------------------------------- >O_latipes_ENSORLP00000010095 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MASNRPGEDSTDARKDNGELA---------------------------- ------------------------------------------------------------ ------------------AGASPAPDRMDVDGKPS------------------------- -SH-SFRYSLNF---PTIGLCIIINNKNFD-RGT--------G--MNQRNGT-DIDAASA -MKVFSKLGYR-VKIYNDQTVKQIKQLLTDVSR-MDHS--DSASFVCILLSHGD-E---- ---G-VFFGTDG-S-------------IELKTLTSLFRGDHCKSLVGKPKLFFIQ--ACR ----GTEL-DDGI-EAD-SKE-------------------------------D----TTK IPVEADFLYAFSTAP--GYYSWRNTMTGSWFINSLCEMLSKYG-------KELELLHIMT RVNHMVAVE---FESIST-LP--GFHA------KKQIPCI-VSMLTKEMYFYP------- -------------------------------------------------- >E_caballus_ENSECAP00000013268 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---G-------------EEQNMTEIDAFYK-REMF------------------------- -DP-AEKYKMDH---KRRGIALIFNHERFF-WHL--------T--LPDRRGT-SADRDNL -MRRFSDLGFE-VKCFNDLKAEELLLKIYEVST-SSHA--DADCFVCVFLSHGE-G---- ---N-HIYAYDA-K-------------IEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACR ----GDQH-DVPV-TPL---DVVDHGTDKLD------------A-NVTQVD-A-AS-VYT LPAGADFLMCYSVAE--GYYSHRETINGSWYIQDLCEMLARFG-------SSLEFTELLT LVNRKVSQR---RVDFCK-DP--SAIG------KKQVPCF-ASMLTKKLHFFPKSK---- -------------------------------------------------- >B_taurus_ENSBTAP00000016642 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MSSEPPPRRAR---------- -GPG-------------EEQNMTEIDAFPR-REIF------------------------- -DP-TEKYKMDH---KRRGIALIFNHERFF-WHL--------T--LPNRPGT-SADRDNL -RRRFSDLGFE-VKCFDDLRAEELLLKIHEAST-ASHV--DADCFLCVFLSHGE-G---- ---N-HIYAYDA-K-------------IEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACR ----GSQH-DVPV-IPL---DVVDHRTDTPD------------A-NLTQVD-A-AS-VYT LPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKFG-------SSLEFTELLT LVNRKVSQR---RVDFCR-DP--NAIG------KKQVPCF-ASMLTKKLHFSPKSK---- -------------------------------------------------- >O_latipes_ENSORLP00000010793 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MDMAETAEELSGKDQVDTKPVISKRSP--------------------------- ------------------------------------------------------------ ------------------ANQPNPRSTDVCVIKQD------------------------- -AD-PYRYSMDY---PKMGICLIINNKNFH-KDS--------G--MGPRNGT-DNDAAAA -WKSFMKLGYE-IQMYNDQTVDQMKKLFRQMSN-QDHS--KFASFACVILSHGE-E---- ---G-VIYGTDG-P-------------VSFNKLIECLKGRSCLSLVGKPKLFFIQ--ACR ----GTLF-DEGI-EHD-AKD---------------------------------DT-SEK IPLEADFLFAYSTVS--GYYSWRSTANGSWFIQSLCEMLEKFS-------KTLDLMQIMT RVNHKVATH---FESSSN-AP--GFSG------KKQIPCI-VSMLTKDFYFPYESN---- -------------------------------------------------- >D_rerio_ENSDARP00000093958 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MKH---AKRGLALIFNQKDFS-L-L--------G--LKTRKGT-DKDRDSL -VSRFEELDFE-VKAYNDYSRDKVLKEIKEVAA-ADHV--DADCFVCIFLSHGE-D---- ---G-HVYANDE-K-------------IKIPEITDLFKGDKCRGLVGKPKIFIWQNKACR ----GDKK-DDPV-APM---SAEDSD-------------------DEMAVD-A-GV-SNT LPAGADFIMCYSTTE--GFCSFRDPLNGTWYIQDLCEIMGRYR-------SQLEFTNILT LVNRKVSLR---SI--CD-DL--SATG------TKQMPCF-ASMLTKRLFFRPKK----- -------------------------------------------------- >M_domestica_ENSMODP00000007353 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KSFGLFFVF---------- -EGD-------------AEQNATEIDAFFK-SKPL------------------------- -DP-AEQYKMDH---KRRGVALIFNHERFF-WHL--------T--LPERRGT-RADRDNL -RQRLSDLGFE-VNCFDDLKAEDLLMTIHMVST-SSHI--DADCFLCVFLTHGE-G---- ---N-HIYAYDA-K-------------IDIQKLTAMFKGDKCQTLVGKPKIFVIQ--ACR ----GDQH-DIPV-IPL---DVVDHLSDKVD------------V-NETEVD-A-AS-VYT LPAGADFLMCYSVAE--GYYSHRETVHGSWYIQDLCEMLEKYG-------SSLEFTELLT LVNRKVSQR---RVDFCK-DP--NAIG------KKQVPCF-ASMLTKKLYLFPKPK---- -------------------------------------------------- >G_gallus_ENSGALP00000017288 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MMTDIKDGPRSGEDVSDARSFPGSK----------------------------- ------------------------------------------------------------ ---------------------GMNLPASKSVDSGI------------------------- -LP-DDSYRMDY---PEIGVCVIINNKNFH-RDT--------G--LSSRSGT-DADAASV -REVFMKLGYK-VKLNNDLSSRDIFKLLKNVSE-EDHS--KRSSFVCVLLSHGD-E---- ---G-LFYGTDG-P-------------LELKVLTSLFRGDKCRSLAGKPKLFFIQ--ACR ----GTEL-DSGI-EAD-SGP-----------------------------D-E-TV-CQK IPVEADFLYAYSTAP--GYYSWRNAAEGSWFIQSLCRMLKEHA-------RKLELMQILT RVNRRVA-E---YESCST-RQ--DFNA------KKQIPCI-VSMLTKEFYFPC------- -------------------------------------------------- >M_musculus_ENSMUSP00000029626 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------MTETDGFYKSREVF------------------------- -DP-AEQYKMDH---KRRGVALIFNHERFF-WHL--------T--LPERRGT-NADRDNL -TRRFSDLGFE-VKCFNDLRAEELLLKIHEVST-SSHI--DADCFICVFLSHGE-G---- ---N-HVYAYDA-K-------------IEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACR ----GSQH-DVPV-VPL---DMVDHQTDKLD--------------NVTQVD-A-AS-VYT LPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLARYG-------SSLEFTELLT LVNRKVSQR---RVDFCK-DP--DAIG------KKQVPCF-ASMLTKKLHFCPKPSK--- -------------------------------------------------- >P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MSSASGLRRGH---------- -PAG-------------GEENMTETDAFYK-REMF------------------------- -DP-AEKYKMDH---RRRGIALIFNHERFF-WHL--------T--LPERRGT-CADRDNL -TRRFSDLGFE-VKCFNDLKAEELLLKIHEAST-VSHA--DADCFVCVFLSHGE-G---- ---N-HIYAYDA-K-------------IEIQTLTGLFKGDKCHSLVGKPKIFIIQ--ACR ----GNQH-DVPV-IPL---DVVDNQTEKLD------------T-NITEVD-A-AS-VYT LPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFTELLT LVNRKVSQR---RVDFCK-DP--SAIG------KKQVPCF-ASMLTKKLHFFPKSN---- -------------------------------------------------- >P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MSSVSGLRRGH---------- -PAG-------------GEENMTETDAFYK-REMF------------------------- -DP-AEKYKMDH---RRRGIALIFNHERFF-WHL--------T--LPERRGT-CADRDNL -TRRFSDLGFE-VKCFNDLKAEELLLKIHEVST-VSHA--DADCFVCVFLSHGE-G---- ---N-HIYAYDA-K-------------IEIQTLTGLFKGDKCHSLVGKPKIFIIQ--ACR ----GNQH-DVPV-IPL---DVVDNQTDKLD------------T-NITEVD-A-AS-VYT LPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFTELLT LVNRKVSQR---RVDFCK-DP--SAIG------KKQVPCF-ASMLTKKLHFFPKSN---- -------------------------------------------------- >H_sapiens_ENSP00000265164 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MSSASGLRRGH---------- -PAG-------------GEENMTETDAFYK-REMF------------------------- -DP-AEKYKMDH---RRRGIALIFNHERFF-WHL--------T--LPERRGT-CADRDNL -TRRFSDLGFE-VKCFNDLKAEELLLKIHEVST-VSHA--DADCFVCVFLSHGE-G---- ---N-HIYAYDA-K-------------IEIQTLTGLFKGDKCHSLVGKPKIFIIQ--ACR ----GNQH-DVPV-IPL---DVVDNQTEKLD------------T-NITEVD-A-AS-VYT LPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFTELLT LVNRKVSQR---RVDFCK-DP--SAIG------KKQVPCF-ASMLTKKLHFFPKSN---- -------------------------------------------------- >C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SSATCGLRRAY---------- -RTA-------------DEQNVTETDAFYK-REMF------------------------- -DP-EEKYKMDH---KRRGIALIFNHERFF-WHL--------T--LPDRRGT-SADRDNL -VRRFSELGFE-VKCFNDLKAEELLLKIHEAST-SSHI--DADCFLCVFLSHGE-G---- ---N-HIYAYDA-K-------------IEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACR ----GDQH-DVPV-LPL---DVVDHRTDKLE------------D-NVTEVD-A-AS-VYT LPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKFG-------SSLEFTELLT LVNRKVSQR---RVDFCK-DP--NAIG------KKQVPCF-ASMLTKKLHFFPKSK---- -------------------------------------------------- >X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------MEESHNGVQYGEDTADAKTYFTNQQ---------------------------- ------------------------------------------------------------ ------------------ISLQNCDIKDMEKKTKF------------------------- -AH-LHKYRTDY---PEMGICLIINNKNFQ-SST--------N--MGVRNGT-DVDARKL -HETFTGLGYK-VKVCNDQKSNDIFTLLKKMSE-EDHS--KRSSFVCAILSHGE-D---- ---G-LVYGVDG-P-------------IQIKNLTDLFRGDRCKTLVGKPKLFFIQ--ACR ----GTDL-DSGI-ETD-SGS----------------------------EP-G-EE-IQR IPVEADFLYAYSTVP--GYYSWRNTMNGSWFIQSLCEMIKLYG-------PHLELIQILT CVNHMVALE---FESCST-QQ--AFHA------KKQIPCV-VSMLTKAFYFLK------- -------------------------------------------------- >M_musculus_ENSMUSP00000091238 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENNKTSVDSKSINNFE----------------------------- ------------------------------------------------------------ ---------------------VKTIHGSKSVDSGI------------------------- -YL-DSSYKMDY---PEMGICIIINNKNFH-KST--------G--MSSRSGT-DVDAANL -RETFMGLKYQ-VRNKNDLTREDILELMDSVSK-EDHS--KRSSFVCVILSHGD-E---- ---G-VIYGTNG-P-------------VELKKLTSFFRGDYCRSLTGKPKLFIIQ--ACR ----GTEL-DCGI-ETD-SGT----------------------------DE-E-MA-CQK IPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQSLCSMLKLYA-------HKLEFMHILT RVNRKVATE---FESFSL-DS--TFHA------KKQIPCI-VSMLTKELYFYH------- -------------------------------------------------- >O_anatinus_ENSOANP00000000517 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------AASGEVMVDSKSFHSSQ----------------------------- ------------------------------------------------------------ ------------------GYSSRKVPGKQFLGSSA------------------------- -SL-DDRYRMDY---PNMGICLIINNKNFH-PDT--------R--MGCRSGT-DVDAASL -RDTFKKLKYE-VRCKNDLKRREILELLTSVAH-EDHS--KRSSFVCVLLSHGE-E---- ---G-VIFGTDG-S-------------LELKSLASLFRGDNCRSLVGKPKLFIVQ--ACR ----GTEL-DSGV-EAD-SSS----------------------------AD-D-GS-EQK IPVEADFLYAYSTAP--GYYSWRNSMNGSWFIQALCAMLKQHA-------HTLELLHILT RVNRKVATE---FESYSL-DA--TFNA------KKQIPCI-VSMLTKELYFPY------- -------------------------------------------------- >D_rerio_ENSDARP00000072390 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AFEPYKKH---KNIGKCLIISNEHFP-VQF--------S--LNRKKGN-SVDERRL -SSTFKSLGFH-VKVENNLSANQMIDALRTVSE-EDHT--DNSCFVCVLMSHGE-E---- ---G-TILGSDERW-------------IPVKTLTSLLTSDLCPSLRDKPKIFFLQ--ACR ----GVEY-DPGV-EAD----------------------------SVEASE-DFFG-ISD VP-ELDFLCCYSTVE--GYFAWRNPETGSIFIRELCKTLMD---------CRLEIIQILT RVNHLVAYY---FQSYTL-EL--ETNR------KRQMPCF-ASRLTKDFYLHV------- -------------------------------------------------- >R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------MTETDGFYRSREVL------------------------- -DP-AEQYKMDH---KRRGTALIFNHERFF-WHL--------A--LPERRGT-NADRDNL -TRRFSELGFE-VKCFNDLRAEELLLKIHEVST-SSHV--DADCFLCVFLSHGE-G---- ---N-HIYAYDA-K-------------IEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACR ----GSQH-DVPV-VPL---DVVDHQTDKLD------------D-NVTQVD-A-AS-VYT LPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLARHG-------SSLEFTELLT LVNRKVSQR---RVDFCK-DP--GAIG------KKQVPCF-ASMLTKKLHFCPKPSK--- -------------------------------------------------- >T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MSANGPASGEDFTDASKG-GEQ----------------------------- ------------------------------------------------------------ ------------------PSGSSSSGKMTVDAKSA------------------------- -RY-SFRYSLDF---PNLGHCIIINNKNFD-RRT--------G--MNTRNGT-DVDAANA -MKVFSNLGYR-VRVHNDQTVAQISQLLTSAAK-EDHS--RCASFVCILLSHGD-E---- ---G-VLYGTDG-P-------------MEIKSLTSLFRGDRCRSLVGKPKLFFIQ--ACR ----GNDL-DGGI-ETD-SIE-------------------------------D-NS-TTK IPVEADFLYAFSTAP--GYYSWRNTMSGSWFMQSLCDTISKYG-------KELELQHILT RVNHKVAVE---FESDSS-LP--GFNA------KKQIPCI-VSMLTKEMYFS-------- -------------------------------------------------- >D_rerio_ENSDARP00000075318 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MADQLLENLRPDLIKGLS ERVINGLLDDLQQKKVFGEEEIEDIQHRMKT-RADQARHVIDDVKRKGVKASEIMLASLK TRDPHLYDTLGIERLLVPVP---------------------------------------- ------------------ETELTPSQLSETTGCST-----------------------DK TNT-MNEYEMKS---NPRGLCLIFNNENF--KDP-----------DMKRHGS-QMDTASL -KDLFEWLGFS-VEIKQDQTVSAMKRTLKEYSE--DRK--HGDCFVCCVLSHGN-E---- ---S-GVLGSDEKI-------------CPVDDITSPFNGANCSSLAGKPKVFFIQ--ACR ----GHEI-QSKV-MVA-DGSGG----------------------SRTQKP-G-RV-SVS IPKDSDFLIARSTVE--GYVSIRDRTSGTWFIQSLCENLKEGS------KRGHDILMILT KVNNDVSRK----EGSLKVKN--EIVD------AKVTPQP-IFTLRKLLIFRPLKKTGRF S------------------------------------------------- >M_domestica_ENSMODP00000005556 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MEDTGTTVDAKSTKNSG----------------------------- ------------------------------------------------------------ ---------------------VKLFHGSKSVESGL------------------------- -S--SDSYKMDY---PEMGLCIIINNKNFH-PNT--------G--MSFRSGT-DVDAASL -SDTFRSLKYE-VRIKNDLTCNEITELLNSVSK-EDHS--QRSSFICVILSHGE-E---- ---G-VIFGTDR-S-------------VELKRLTCFFRGDKCRSLTGKPKLFIIQ--ACR ----GTEL-DCGV-ETD-SGT----------------------------DE-D-IA-CQK IPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQALCAVLKQHA-------HKLEIMQILT RVNRKVATE---FESYSL-DI--SFHA------KKQVPCI-MSMLTKELYFSH------- -------------------------------------------------- >D_rerio_ENSDARP00000075645 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----MDKTSNPNNSNQINRASPNEQEKIKTD-EPKRKNTSQEDKE--------------- ------------------------------------------------------------ ---N-------------LHKGVQNNNSPKRQREPL--------QSTCNISDHYPKRKRAV TEQ-KEWYSMSN---RPLGYCLIINNYKF--ESA--------S--LADRRGT-DRDKDDL -TKVFEKMYFK-VEVRDDLQASDMRNVIKEFAE-KDHS--QMNAFVCCILTHGE-K---- ---G-TVLGTDGKQ-------------VPIRELSQPFA--ECRSLASKPKLFFIQ--ACQ ----GNMR-QQGL-WMA-H-ERENTTEE---------------E-AYEEDA-HAAG-NYS IPMDADFLFAIATVE--HFRSYRHITNGSIFIQVLCKQLERGC-----A-QKKDILSILT AVNGVVGSK--------------ILQG------YKQMPEV-RYTLTKALVLPMNGVS--- -------------------------------------------------- >T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GSDAELGKTATD -SSA-------------CTGDLMETDAISGSIGFL------------------------- -DP-AEEYKMDN---KRRGLALIFNQERFF-WRL--------G--LRDRHGT-NADSYNL -QRRLKELNFE-VKVFDNHTQAQVLEIITSAAK-DDHS--NVDCFLVVFLSHGE-N---- ---D-HIYTFDD-K-------------INVQDITSLFKGDKCKSLVGKPKIFILQ--ACR ----GDKH-DEPA-TAA-AFDDVDSE---LK------------K-NEVEVD-A-SA-VYT LPAGADFIMCYSVAE--GYYSHRETVNGSWYIQDLCDLLRKYG-------DSLEFTELLT LVNRKVSMR---SVGYCS-DP--NAIG------KKQVPCF-ASMLTKKLYFRPKK----- -------------------------------------------------- >G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --D-KYRYKMDY---PCMGTCVIINNKTFD-PKT--------G--LSPRNGT-DVDAAEL -EKTFSRLGYK-VTVANDQTADQMVDLLADVSK-QDHR--KSASFVCALLSHGD-E---- ---D-GIYGTDG---------------TSLDDLTKFFKGDRCRSLVGKPKLFFIQ--ACR ----GTDT-DRGV-NFD-ADS----------------------------TD-G-QM-LQS IPLEADFLYAYSTPS--GYYSWRNTQNGSCFMQSLCEILHSFS--------QLELMQIMT RVNYEVALH---FESSSD-KL--GYSG------KKQIPCI-MSMLTKDFYFPK------- -------------------------------------------------- >T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------RMETDAFYGRNSIV------------------------- -DP-AEEYKMDN---KRRGLAIIFNQESFF-WRL--------G--LKDRHGT-NADSYNL -QRRLRELNFD-VNVYNNYKQQEVLDIINAAAK-ADHS--DVDCFLLVFLSHGE-N---- ---D-HIYANDD-K-------------ISIQDITSLFKGDKCKSLVGKPKIFIWQ--ACR ----GDKH-DEPA-TAA-AFDDVDSE---SK------------K-NEVEVD-A-SA-VHT LPAGADFIMCYSVAE--GYYSHRETVNGSWYIQDLCDLLLRYG-------DSLEFTELLT LVNRKVSMR---SVGYCR-DP--NAIG------KKQVPCF-ASMLTKKLYFRPKKKSK-- -------------------------------------------------- >P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENTENSVDSKSIKNLE----------------------------- ------------------------------------------------------------ ---------------------PKIIHGSQSMDSGI------------------------- -SL-DNSYKMDY---PEMGLCIIINNKNFH-KST--------G--MTSRSGT-DVDAANL -RETFRNLKYE-VRNKNDLTREEIVELMRDVSK-EDHS--KRSSFVCVLLSHGE-E---- ---G-IIFGTNG-P-------------VDLKKITNFFRGDRCRSLTGKPKLFIIQ--ACR ----GTEL-DCGI-ETD-SGV----------------------------DD-D-MA-CHK IPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFMHILT RVNRKVATE---FESFSF-DA--TFHA------KKQIPCI-VSMLTKELYFYH------- -------------------------------------------------- >H_sapiens_ENSP00000311032 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENTENSVDSKSIKNLE----------------------------- ------------------------------------------------------------ ---------------------PKIIHGSESMDSGI------------------------- -SL-DNSYKMDY---PEMGLCIIINNKNFH-KST--------G--MTSRSGT-DVDAANL -RETFRNLKYE-VRNKNDLTREEIVELMRDVSK-EDHS--KRSSFVCVLLSHGE-E---- ---G-IIFGTNG-P-------------VDLKKITNFFRGDRCRSLTGKPKLFIIQ--ACR ----GTEL-DCGI-ETD-SGV----------------------------DD-D-MA-CHK IPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFMHILT RVNRKVATE---FESFSF-DA--TFHA------KKQIPCI-VSMLTKELYFYH------- -------------------------------------------------- >X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MASAKQQSSPSAGQIEKDSSSASQ -NKE-------------QKANVAETDGWTSRTLEL------------------------- -DP-SAEYKMTH---KRRGLALIFNHEDFY-WQL--------R--LGSRRGT-NTDSMNL -NRILTDLGFD-VQNYYNLRTLDILEKIQEAST-ADHS--NADCFLCVFLSHGE-D---- ---R-HIYSYDS-L-------------IDIQELTNSFKGDKCESLVGKPKIFIFQ--ACR ----GEKH-DNPV-LPT---DETDSVT---L------------T-NITEVD-A-AS-LYT LPAGADFIMCYSVAE--GYYSHRETVNGSWYIQDLCEVLKAHA-------ASLEFTEILT LVNRKVSQR---SVAFCN-DP--KAIG------KKQIPCF-SSMLTKKLFLKPKSN---- -------------------------------------------------- >T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------TNMSANGPSPGGDFTDAKKGAGQQ----------------------------- ------------------------------------------------------------ ------------------PRSGSSSGRVTVDAKPA------------------------- -AY-SFRYSLDF---PNMGHCIIINNKNFD-RRT--------G--MNTRNGT-DVDAANA -MKVFLSLGYK-VKVHNDQTVNQMKQLLVSAAE-EDHS--ACASFVCVLLSHGD-E---- ---G-VFFGTDG-S-------------VELKYLTSLFRGDRCKSLVGKPKLFFIQ--ACR ----GNDL-DGGI-ETD-SAA-------------------------------D-SS-TTK IPVEADFLYAFSTAP--GYYSWRNTTSGSWFMQSLCDAISKYG-------KELELQHILT RVNHKVAVD---FESVSN-LP--GFDA------KKQIPCI-VSMLTKEMYFS-------- -------------------------------------------------- >A_gambiae_AGAP011950-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------MDSLLELE------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----LQSYKTNH---PNRGIAVVIND-------------------SENRDGW-EKDLEAV -ETVLQRLKCD-VRTFCDKTKHEIRDALRNVSK-EDHT--KSDCLVIVAMAHGN-N---- ---D-KITLRRG-E-------------MHIDELWTDFVGNGCPSLIGKPKLVFIQ--SCR ----GNKH-DYLV-GGA-AV-----------------------D-AVPSPE-K-PI-CVE IPMYADLLVMYSSYD--QYVSYRDKEEGSWFIQSLCQVLGANI-------AGKDLLTLLT HVSYLVSVRSFLMESEVNMVK--RTGV------LKQIPSI-NSMLTKAFYFVDK------ -------------------------------------------------- >T_guttata_ENSTGUP00000006879 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------MTDIGDGAHLGKDLADTKSIPGFK----------------------------- ------------------------------------------------------------ ---------------------GKNLPASKSMDSGI------------------------- -LP-DYSYRMDY---PEMGECIIINNKNFH-RYT--------G--MSPRSGT-DADAASV -REVFMKLGYK-IKINNDLSCEGIFNLLKNVSE-EDHS--KRSSFVCVLLSHGD-E---- ---G-LIYGTDG-P-------------LELKALTSLFRGDRCRSLAGKPKFFFIQ--ACR ----GTEL-DSGI-ETD-SGS-----------------------------E-E-TM-CQK IPVEADFLYAYSTAP--GYYSWRNSAEGSWFIQSLCKMLKEHA-------RKLELMQILT RVNRRVA-E---YESCST-RQ--DFNA------KKQIPCI-VSMLTKEFYFPS------- -------------------------------------------------- >G_gallus_ENSGALP00000013571 ---------------------------------------------------------MSS DFRKLLFDISEALATEELAALKFLSLEHVPVRKQEDTEEPKAFFEVLKEKGMIEVEDLFF LKELLYRINRIDLLASHLGSSREEMERELQVPGKAK---VSAYR---------------- -------------------------QLLYGIAED--LTPDDVRSIKFLLQEKLPKNKLQD NASMLKVLVEMERNGIIKEDDLTMLKSILKA-FRADLKKKIDNYEEKTKGWPWKSSCFPN KTQALS------------------------------------------------------ ------------------ISENLAVSSLIDNKESQ--------ESQSEWYSAGIFPPHVQ ILL-VESYKMEN---NPHGYCVILNNYRF--KNP-----------NETRKGT-VEDGKAL -KRVFKWLQFD-TIEYMDLEAKQIFAKVNEYSK-KDHS--NMDCFVCFILSHGE-K---- ---G-KIKGVDNEL-------------VNIKDLLSCFSGSNCPSLAGKPKLFFIQ--ACQ ----GSVG-HPAV-TVK-EDCS-----------------------GHLETD-A-IP-ALS IPDQADVLVGMATVE--DFECYRSIETGSVYIQCLCDKMELLC-----P-LRKDLITILT EVNKEVGRR--------------VLNG------WKQMPKI-TSTLRKQFIFQIPQCQ--- -------------------------------------------------- >P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENTENSVDSKSIKNLE----------------------------- ------------------------------------------------------------ ---------------------PKVIHGSKSMDSGI------------------------- -SL-DNSYKMDY---PEMGLCIIINNKNFH-KST--------G--MASRSGT-DVDAANL -RETFRNLKYE-VRNKNDLTREEIVELMRDVAK-EDHS--KRSSFVCVLLSHGE-E---- ---G-IIFGTNG-P-------------VDLRKITNFFRGDRCRSLTGKPKLFIIQ--ACR ----GTEL-DCGI-ETD-SGV----------------------------DD-D-MA-CHK IPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFMHILT RVNRKVATE---FESFSL-DA--TFHA------KKQIPCI-VSMLTKELYFYH------- -------------------------------------------------- >R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MDNNETSVDSKSINNFE----------------------------- ------------------------------------------------------------ ---------------------TKTIHGSKSMDSGI------------------------- -YL-DSSYKMDY---PEMGLCIIINNKNFH-KST--------G--MSARNGT-DVDAANL -RETFMALKYE-VRNKNDLTREEIMELMDSVSK-EDHS--KRSSFVCVILSHGD-E---- ---G-VIFGTNG-P-------------VDLKKLTSFFRGDYCRSLTGKPKLFIIQ--ACR ----GTEL-DCGI-ETD-SGT----------------------------DD-D-MA-CQK IPVEADFLYAYSTAP--GYYSWRNSRDGSWFIQSLCAMLKLYA-------HKLEFMHILT RVNRKVATE---FESFSL-DA--TFHA------KKQIPCI-VSMLTKELYFYH------- -------------------------------------------------- >M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENTENSVDSKSIKSLE----------------------------- ------------------------------------------------------------ ---------------------PKIIHGSKSVDSGI------------------------- -SL-ENSYKMDY---PEMGLCIIINNKNFH-KST--------G--MASRSGT-DVDAANL -RETFINLKYE-VRNKNDLTREEIVELMRNVSK-EDHS--KRSSFVCVLLSHGE-E---- ---G-IIFGTNG-P-------------LDLKKITSFFRGDCCRSLTGKPKLFIIQ--ACR ----GTEL-DCGI-ETD-SGV----------------------------ED-D-MA-CHK IPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFMHILT RVNRKVATE---FESFSL-DA--TFHA------KKQIPCI-VSMLTKELYFYH------- -------------------------------------------------- >O_anatinus_ENSOANP00000001054 ------------------------------------------------------------ ---XLLFSIGEELAADDLEALKFLCLDLIPLKKQETIQDALGLFRLLQEKGMLEEGKLSF LKELLFRIHRIDLLKAHLGTSHGDVERELEEPGRAQ---VSAYR---------------- -------------------------ITTETITGG--SNKGIIKXFFFFSSQREKKMRSDA VSTALGIFIHMEKHGKMNEGDLGMLKKILKD-VQPSLLIPIEEYEEKSRGFCVSQSRSSW KLKHCLGTTLPHHSYRNY------------------------------------------ ------------------NQQVSSPKAAEEMERIS------------------------- -QI-MAPYKMNH---LPHGFCVIINNSEF--QNP-----------QNTRRGA-DKDAAAL -DKVFSWLQFK-VEHHNNLKGEAISRVLRAYSE-RDHT--DQDCFICCLLSHGQ-K---- ---G-EILGTDWEP-------------VPLRALLGLFTSSACRTLATKPKIFFVQ--ACQ ----GGQG-QGGL-SLR-GREG-----------------------ALLEAD-A-VV-IPS VPDWADLLVGMATVE--DFICFRRPRHGSEYIQALCRALETFC-----PRRGKDLLTILT HVNKEVGQK--------------VFGS------NKQMPEV-KFTLQCPLIFPVP------ -------------------------------------------------- >R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MTDDQDCAAELEMADSSTEDGVDAKPDRSTIISSLLW----------------------- ------------------------------------------------------------ ------------------KKKKNASMCPVSTTRDR------------------------- -VP-TYLYRMDF---EKMGKCIIINNKNFD-KAT--------G--MDVRNGT-DKDAEAL -FKCFRSLGFE-VTVYNDCSCAKMQDLLRRASE-EDHS--NSACFACVLLSHGE-E---- ---N-LIYGKDG-V-------------TPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR ----GTEL-DDGI-QAD-SGPI---------------------N-D---TD-A-NP-RYK IPVEADFLFAYSTVP--GYYSWRNPGKGSWFVQALCSILNEHG-------KDLEIMQILT RVNDRVARH---FESQSD-DP--RFNE------KKQIPCM-VSMLTKELYFGR------- -------------------------------------------------- >E_caballus_ENSECAP00000013731 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MADDQDCVVEQGAGDSTSTDAVDAKPDRSSFVPSLFS----------------------- ------------------------------------------------------------ ------------------KKKKNGPERSITTNRNR------------------------- -EP-TYQYNMNF---EKVGKCVIINNKNFD-RGT--------G--MGVRNGT-DKDAEAL -FKCFRNLGFD-VVVYNDCSCAKMKSLLKQASE-EDHR--NSACFACILLSHGE-E---- ---N-LIYGTDG-M-------------TPIKDLTGHFRGDRCKTLLEKPKLFFIQ--ACR ----GTEL-DDGI-QAD-SGPI---------------------NDD---TD-A-NP-RYK VPVEADFLFAYSTVP--GYYSWRNPGSGSWFVQALCSILNEHG-------KSLEIIQILT RVNHRVARH---FESHSD-DP--RFHQ------KKQIPCV-VSMLTKELYF--------- -------------------------------------------------- >O_anatinus_ENSOANP00000005811 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PRGATRLARGHP---------- -AAG-------------GAPNVTEVDGFYD-RETF------------------------- -DP-AAKYKMEY---KRRGVALIFNHERFY-WQL--------K--LPDRHGT-RADRENL -IRRLSALGFE-VKCFDDLKAEEVMLKIHQASS-SNHA--DADCFLCVFLSHGQ-G---- ---N-HVYAYNG-K-------------IDIPEMTSMFKGDQCRSLVGKPKIFIFQ--ACR ----GEQH-DVGV-VPL---DVVDSKISEQD------------V-NETEVD-A-AS-VYT LPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGRYG-------SSLEFTELLT LVNRKVSYR---RVDFCK-DP--SLIG------KKQVPCF-ASMLTKKLHFLPKAQ---- -------------------------------------------------- >A_gambiae_AGAP012544-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MDATIINNNHSSLEAMDSTLQLT------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----LHSYNMAH---PKRGIAVVINN-------------------NRDRKGS-EKDVKAL -QAVLSHLQFD-VRLLSDKTTVEIRHALKEVSK-EDHT--NNDCLAIIAMAHGY-N---- ---D-RIKFDDD-Y-------------LHIDELWTNFVGNKCPSLIGKPKLVFIQ--SCR ----GGKL-DYGA-SIA-TA-----------------------D-ARPGLE-E-PV-DVK IPMYADLLVMYSSFE--HHSSIRCRNEGSWFIQSFCQVLGANI-------AKTELQALLC HVSYLVSIR-----SDQTIDP--EGKV------VKQIPMV-TSMLTKAFYFVPK------ -------------------------------------------------- >D_rerio_ENSDARP00000006831 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MNGDCVDAKRVDTTDAS--------------------------- ------------------------------------------------------------ ------------------KDGASASQPMQVDAKPQ------------------------- -SH-AFRYSLNY---PNIGHCIIINNKNFD-RRT--------G--MNPRNGT-DVDAGNV -MNVFRKLGYI-VKVYNDQTVAQIMQVLTTVAH-DDHS--RCASLVCVLLSHGD-E---- ---G-VFFGTDT-S-------------VDLKSLTSLFRGDRCPSLVGKPKLFFIQ--ACR ----GTEL-DPGV-ETD-HPD---------------------------HPDIP-DG-RVR IPVEADFLYAYSTVP--GYYSWRNTMTGSWFIQSLCEMMTKYG-------SELELLQIMT RVNHKVALD---FESTSN-MP--GFDA------KKQIPCI-VSMLTKEMYFTP------- -------------------------------------------------- >M_domestica_ENSMODP00000005560 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MEDTGTTVDAKSIKNSG----------------------------- ------------------------------------------------------------ ---------------------VKSLHSSKSVESGL------------------------- -S--SDSYKMDY---PEMGLCVIINNTHFH-NDT--------E--LSPRTGS-DKDAANL -IDIFRSLKYE-VRNKNNLTRDKMIELLRQVSE-EDHS--QRSSFVCVILSHGE-E---- ---G-VIFGTDD-S-------------VELKELTYFFKGYKCKSLTGKPKLFIIQ--ACQ ----GREF-DCGV-ETD-SGT----------------------------DE-D-VA-CHK IPVEADFLYAYSTVP--GYYSLRDPKDGSWFIQALCAVLKQHA-------HKLEIMQILT RVNRKVATE---FESYSS-KA--SLHA------KKQMPCI-MSMLTKELYFSH------- -------------------------------------------------- >A_gambiae_AGAP010826-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MTWDDVMRMENEMEQ----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ AKRREHFYDL-----SKDAYVIVFHNDEF--DNS-----------ACNRPGS-AKDMERI -QQVLQHYRCDKLDINENKPEEYVQQKMTEISQ-KDFT--PYSCLIVFIMSHGSVN---- ---D-TILASDGKW-------------FYFQEDI-VDKCTSNRTLDGKPKLFVLQ--ACR ----GNDR----I-VA--------------------------------------DA-RPP RSDKVDVIIFQSTYQ--GMIT--------------------------------------- ------------------------------------------------------------ -------------------------------------------------- >C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MGEQRNTSSKELAA AEATGQSGKELEVSMENTENSVDAKSFKNAE----------------------------- ------------------------------------------------------------ ---------------------TVIV---KILKDKY------------------------- -LT-KLHYKMDY---PEMGLCIIINNKNFH-KST--------G--MAPRSGT-DVDAANL -RETFTNLKYE-VRNKNDLTCEEILELMNSVSK-EDHS--KRSSFVCVLLSHGD-E---- ---G-IIFGTNG-P-------------VDLRKVTGFFRGDYCRSLTGKPKLFIIQ--ACR ----GTEL-DCGI-ETD-SGI----------------------------ED-D-MA-CQK IPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKLYA-------HKLEFMHILT RVNRKVATE---FESFSL-DS--AFHG------KKQIPCI-VSMLTKELYLYH------- -------------------------------------------------- >O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MADDQAHAGELGAGDSESADAVDAKPDRSSFVPALFS----------------------- ------------------------------------------------------------ ------------------KKKKNGPKQSAKATRDQ------------------------- -VP-SYQYNMNF---DKMGKCIIINNKNFD-KVT--------G--MGVRNGT-DKDAEAL -FKCFRSLGFD-VMVYNDCSCARMQDLLKRASE-EDHT--NSACFACILLSHGE-E---- ---N-LIYGKDG-V-------------IPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR ----GTEL-DDGI-QAD-SGPI---------------------N-D---TD-A-NP-RHK IPVEADFLFAYSTVP--GYYSWKNPGRGSWFVQALCSILDEHG-------KELEVMQILT RVNDRVARH---FESQSD-DP--RFNE------KKQIPCV-VSMLTKELYFCR------- -------------------------------------------------- >B_taurus_ENSBTAP00000021099 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENTENSVDSKSIKTSE----------------------------- ------------------------------------------------------------ ---------------------TKILHGSKSMDSGI------------------------- -SL-EESYKMDY---PEMGLCIIINNKNFH-ENT--------G--MCRRSPT-DDSVAQX -RETFMNLKYE-VRIKNDLTCKEMLELMSNVSK-EDHS--KRSSFICVLLSHGE-E---- ---G-IIFGTNG-P-------------VNLKKLASFFRGDYCRSLTGKPKLFIIQ--ACR ----GTEL-DCGI-ETD-SGA----------------------------ED-D-MA-CQK IPVEADFLYAYSTAP--GYFSWRNAKNGSWFIQALCEMLKKHA-------HRLELMHILT RVNRKVAIE---YESFST-DS--AFHA------KKQIPCI-MSMLTKELYF--------- -------------------------------------------------- >G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MSVNGPGEDRTDAKTEQS------------------------------- ------------------------------------------------------------ ------------------EVSSSASAPEEVDAKPN------------------------- -VH-SFRYSLSF---PSIGQCIIINNKNFD-RGT--------G--MNQRNGT-DVDAANA -MKVFGNLGYK-VKVYNDQSVAQIQHVLTSVSK-QDHS--CSASFVCVLLSHGD-G---- ---D-LFFGTDG-P-------------VPLKSLTSLYRGDRCKSLVGKPKLFFIQ--ACR ----GTEL-DPGI-EAD-SVK---------------------------------DE-TTR IPVEADFLYAFSTAP--GYYSWRNTTTGSWFMQSLCDMISKYG-------KELELQHIMV RVNHKVAVA---FESVSN-SP--DFNA------RKQIPCV-VSMLTKEMYFSP------- -------------------------------------------------- >B_taurus_ENSBTAP00000008706 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------S----------------------- ------------------------------------------------------------ ------------------KKKKNDSGKSVNIPRDR------------------------- -VP-TYQYNMNF---EKVGKCIIINNKNFD-RIT--------G--MGVRNGT-DKDAEAL -FKCFRSLGFD-VSVYNDCSCAKMQDLLKKASE-EDHR--NSACFACILLSHGE-E---- ---N-LIYGTDG-K-------------TAIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR ----GTEL-DDGI-QAD-SGPI---------------------N-D---TD-A-NP-RYK IPVEADFLFAYSTVP--GYYSWRNPGSGSWFVQALCSILNEHG-------KSLEILQILT RVNDRVARH---FESQSD-DP--RFHE------KKQIPCV-VSMLTKELYF--------- -------------------------------------------------- >D_melanogaster_FBpp0071971 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MTDECVTRNY GVGIRSPNGSENRGSFIMADNTDAKGCTPESLVVGGAT---------------------- ------------------------------------------------------------ ------------------AASPLPANKF-VARMPV------------------------- -ERYASEYNMSH---KHRGVALIFNHEFFD-IPS-----------LKSRTGT-NVDAQEL -KKAFENLGFA-VSVHKDCKLRDILKHVGKAAE-LDHT--DNDCLAVAILSHGE-H---- ---G-YLYAKDT-Q-------------YKLDNIWHYFTATFCPSLAGKPKLFFIQ--ACQ ----GDRL-DGGI-TLE-KGV------------------------TETDGE-S-ST-SYK IPIHADFLFSYSTIP--GYFSWRNINNGSWYMQSLIRELNANG-------KKYDLLTLLT FVNQRVALD---FESNVPATP--MMDR------QKQIPCL-TSMLTRILRFGDKPNGNKA G------------------------------------------------- >E_caballus_ENSECAP00000019797 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MENSKISVDSKSIKNSE----------------------------- ------------------------------------------------------------ ---------------------TKILHGSKSMDSGI------------------------- -SL-DSSYKMDY---PEMGLCIIINNKNFH-KST--------G--MASRSGT-DVDAANL -RETFTNLKYE-VRNKNDLTGEEIVALMRSVSK-EDHS--KRSSFICVLLSHGE-E---- ---G-IIFGTNG-P-------------IDLKKLTCFFKGDCCRSLAGKPKLFIIQ--ACR ----GTEL-DSGI-ETD-SGI----------------------------ED-D-MA-CQK IPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKLYA-------HKLELMHILT RVNRKVAME---FESYCL-DP--TFHG------KKQIPCI-VSMLTKELYFYH------- -------------------------------------------------- >A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------FRR-NHLF------------------------- -DP-AAEYKMSH---KRRGLALIFNHEHFF-WHL--------M--LPERRGT-QADKENL -KRGLTDLGFE-VKCFDDLKAEEVLQNIYNVST-DEHD--DADCFLCVFLSHGE-D---- ---D-HVYAYDA-K-------------IEIKSLTNMFKGDKCPSLVGKPKIFVIQ--ACR ----GDKH-DDPV-IAR---DTVDSK-KELD------------I-NETEVD-T-AA-VYT LPAGADFLMCYSVAE--GYYSHRETINGSWYIQDLCEMLKRHG-------SSLEFTDLLT LVNRKVSHR---EVDVCK-DR--KALG------KKQIPCF-ASMLTKKLYFRPKFK---- -------------------------------------------------- >M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------S----------------------- ------------------------------------------------------------ ------------------KKKKNVSGQSIKTTRDR------------------------- -VP-TYQYNMNF---EKMGKCIIINNKNFD-KVT--------G--MGVRNGT-DKDAEAL -FKCFQSLGFD-VIVHNDCSCAKMKDLLKKASE-EDHT--NAACFACILLSHGE-E---- ---N-LIYGKDG-V-------------TPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR ----GTEL-DDGI-QAD-SGPI---------------------N-D---TD-A-NP-RYK IPVEADFLFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIMQILT RVNDRVARH---FESQSD-DP--CFHE------KKQIPCV-VSMLTKELYFSH------- -------------------------------------------------- >D_rerio_ENSDARP00000041413 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MALIFNQKQFD-WKL--------G--LKTRNGT-DKDRDDL VSRRFQELNFE-VKAYNDYSRDDVLLKIQEASA-ADHV--DADCFVCIFLSHGE-D---- ---G-HVYANDK-K-------------IEIPEITDLFKGDKCRSLVGKPKIFIWQKQACR ----GDKL-DDAV-TEM---SVEDV---------------------EMAVD-A-GV-LYT LPAGADFIMCYSTAE--GFCSFREPLNGSWYIQDLCEILGRYH-------SELQFTDILT LVNMKVSLR---SVPNCR-NR--AAIG------KKQMPCF-ASMLTKRLFFRDNTQIQ-- -------------------------------------------------- >C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MSLKSAAD VLMSGVPTPHTNENNNVGQSEVDALGS--------------------------------- ------------------------------------------------------------ ------------------GETPRIYSLPDVTKMAS------------------------- -SE-VECYQMDR---ESRGLALIINNENFH-HAT--------R--MNKRSGT-DVDARNL -SRIFKKLGFD-VQVYKDLSCISMLEVINEVST-MDHT--GNDCCFVAFLSHGD-D---- ---G-CVYGTDG-I-------------VQIKKIVDQFRGDVCPSLAGKPKIFLFQ--ACR ----GTLH-ETSV-QLS-V-DVVDGED----------------Q-PCVEVD-A-AP-VPT LPSGSDYLFCYSVAE--GYYSHRDTLYGSWFIQDFTDVMEQLVLNKGKQQDKVDFIDVLT VVNRKVSAR---RVERSY-SQ--QALG------KKQMPCY-LSMLTKKLYLTPKK----- -------------------------------------------------- >M_musculus_ENSMUSP00000026062 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MTDDQDCAAELEKVDSSSEDGVDAKPDRSSIISSILL----------------------- ------------------------------------------------------------ ------------------KKKRNASAGPVRTGRDR------------------------- -VP-TYLYRMDF---QKMGKCIIINNKNFD-KAT--------G--MDVRNGT-DKDAGAL -FKCFQNLGFE-VTVHNDCSCAKMQDLLRKASE-EDHS--NSACFACVLLSHGE-E---- ---D-LIYGKDG-V-------------TPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR ----GTEL-DDGI-QAD-SGPI---------------------N-D---ID-A-NP-RNK IPVEADFLFAYSTVP--GYYSWRNPGKGSWFVQALCSILNEHG-------KDLEIMQILT RVNDRVARH---FESQSD-DP--RFNE------KKQIPCM-VSMLTKELYFSR------- -------------------------------------------------- >P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MDCVGWPPGRRWHLEKNTSCSGSSGICASYVTQ MADDQGCVEEQGLGDSANEDSVDAKPDRSSFVPFLFS----------------------- ------------------------------------------------------------ ------------------MKKKNVSMQSIKTTRDR------------------------- -VP-TYQYNMNF---EKLGKCIIINNKNFD-KVT--------G--MGVRNGT-DKDAEAL -FKCFRSLGFD-VIVYNDCSCAKMQDLLKKASE-EDHT--NAACFACILLSHGE-E---- ---N-LIYGKDG-V-------------TPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR ----GTEL-DDGI-QAD-SGPI---------------------N-D---TD-A-NP-RYK IPVEADFLFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIMQILT RVNDRVARH---FESQSD-DP--RFHE------KKQIPCV-VSMLTKELYFSQ------- -------------------------------------------------- >A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------IPVSKSVDSVI------------------------- -EA-DESYRMDH---PEMGLCILVNNKNFH-PAT--------G--MSYRSGT-DRDAAHV -VDTFRTLGYM-VKPYNDLTCKQIVDVLHNVSK-DDHH--KRNSFVCVLLSHGE-D---- ---G-LIYGTDG-H-------------VELKMLTSFFRGDKCKSLAGKPKLFFIQ--ACR ----GTEL-DSGI-ETD-SAS-----------------------------D-E-SM-CQK IPVEADYLYAYSTAP--GYYSWRNSSDGSWFIQSLCSMLKQYS-------HKLELMQILT RVNRKVT-E---FTSCSN-HP--DFHG------KKQIPCI-MSMLTKDFYFPH------- -------------------------------------------------- >D_rerio_ENSDARP00000095527 ------------------------------------------------------------ MDPQIFHEIDENLTSGDVDQLKFLCLDFIPKRRLESVTDAKDLILRLDEQGLLEDEL--L FPELLITIGRIDLLEILKKSKEEVKRNLLRCDNSRKG--VSAYR---------------- -------------------------KMLLKISED--MTEENFRAAKFLL--DLPRAKLGR STSFLDTLIEMEKQQRLGPDNLDELYRILEK-CDKQLAVMIERFRNQSHRDQEQGGRLPL EEVFL------------------------------------------------------- ------------------NNPVSETMERERRRNSS--------------AGTITTDAETP LNK-KKFYISST---APLGICFLRKMLTFLQEFV-----------MLKFLSL-SLSADRL -AKLFSRMHFQ-IEVRSDLEAWAIKDEIKQFAN-KNHA--SMGAFVCCILSHGE-K---- ---G-TVLGTDGKP-------------VEIREVTLPFAG--CRTLASKPKLFFIQ--ACQ ----GDEN-QAGV-WTS-DGREDAPEE----------------DEKYEEDA-GIIV-LRK IPIEADFLIGMATVE--HYLSYRHTKEGSIFIQELCKKMEELC-----P-KKEDMLSILT KVNFEVSKR--------------ILKG------YKQMPEP-RYTLTKKLVLPID------ -------------------------------------------------- >H_sapiens_ENSP00000358327 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQ MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFS----------------------- ------------------------------------------------------------ ------------------KKKKNVTMRSIKTTRDR------------------------- -VP-TYQYNMNF---EKLGKCIIINNKNFD-KVT--------G--MGVRNGT-DKDAEAL -FKCFRSLGFD-VIVYNDCSCAKMQDLLKKASE-EDHT--NAACFACILLSHGE-E---- ---N-VIYGKDG-V-------------TPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR ----GTEL-DDGI-QAD-SGPI---------------------N-D---TD-A-NP-RYK IPVEADFLFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIMQILT RVNDRVARH---FESQSD-DP--HFHE------KKQIPCV-VSMLTKELYFSQ------- -------------------------------------------------- >P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQ MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFS----------------------- ------------------------------------------------------------ ------------------KKKKNVTMRSIKTTRDR------------------------- -VP-TYQYNMNF---EKLGKCIIINNKNFD-KVT--------G--MGVRNGT-DKDAEAL -FKCFRSLGFD-VIVYNDCSCAKMQDLLKKASE-EDHT--NAACFACILLSHGE-E---- ---N-VIYGKDG-V-------------TPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR ----GTEL-DDGI-QAD-SGPI---------------------N-D---TD-A-NP-RYK IPVEADFLFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIMQILT RVNDRVARH---FESQSD-DP--RFHE------KKQIPCV-VSMLTKELYFSQ------- -------------------------------------------------- >A_aegypti_AAEL003444-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MDTTDELDVLGFGSRT----------------------------- ------------------------------------------------------------ ------------------NESSKSIKEALVSRAAL------------------------- ----DEYYDTTN---KRRGIALVFCHMNFS------------V--MAKRNGA-DKDRDDI -CNTLYGLDFD-VRVFDDLSRKEVLDRLKDVSR-EDHS--DNDCLVVVMMSHGE-Q---- ---G-VLYARDN-K-------------YNVDSLWKNFVGNACPSLIGKPKMFFIQ--ACR ----GEQF-DEGV-AYA-AKSPK--------------------DMVDS-RQ-E-QV-LYS IPAMADLLVMYSTYD--GYYSWRNPRQGSWFIQSLCTELDENG-------RVRDLLTLLT GVSRRTAYE---FQSFVPHNA--KMDA------MKQIPCI-VSMLTKTFYFTKKTRSRVV TDID---------------------------------------------- >A_gambiae_AGAP009832-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QPLTKAFSAMFSRKQEDSSDTRGMPHGSPI--------------------------- ------------------------------------------------------------ ------------------ASGSQTANGIIRPAYVI------------------------- -ERYAAYYPMNH---KRRGMALIFSHNKYNVRNV--------S--LPVREGS-AIDCKRL -KETLELFRFD-VKVYPDFKLEEIKSVIGKVSS-MDHS--DSDCFLVAILTHGE-D---- ---GGIVYAYDQ-P-------------YELSLIWSFFTADNCPSLAGRPKIFVVQ--ACR ----GNQL-DHGV-KVQ--------------------------------KD-G-VA-RYS IPTHADFLFAYATIP--GFMAFRNTTEGSWFINELCKELQENG-------HRYDINTLLT FVTQKVAYD---HESVSN-MP--EYNM------RKQTPCV-VSMLTRLLLFNVV------ -------------------------------------------------- >G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MADDQGCVXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----------------------- ------------------------------------------------------------ ------------------XXXXXXXXXXXXXXXXX------------------------- -XX-XXXXXXXX---XXXXXXXXXXXXXFD-KVT--------G--MGVRNGT-DKDAEAL -FKCFRSLGFD-VIVYNDCSCAKMQDLLKKASE-EDHT--NAACFACILLSHGE-E---- ---N-VIYGKDG-V-------------TPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR ----GTEL-DDGI-QAD-SGPI---------------------N-D---TD-A-NP-RYK IPVEADFLFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIMQILT RVNDRVARH---FESQSD-DP--RFHE------KKQIPCV-VSMLTKELYFSQ------- -------------------------------------------------- >G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------MSPRNGT-DVDAADA -FRTFSKLGYK-VTVANDQTVDQMIQLLVKVSK-QDHS--NSASFVCVLLSHGD-E---- ---G-VIYGTDG-F-------------EKLDDLTKFFKGDRCRSLVGKPKLFFIQ--ACR ----GTEL-DEGS-QIE-ADS----------------------------VG-G-QT-SDR IPVEADFLYAYSTAP--GYYAWRNTQNGSWFMQSLCEMLRRFS-------GQLELMQIMT RLNHRVALH---FESSSD-TP--GYSG------KKQIPCI-VSMLTKDFYFPK------- -------------------------------------------------- >A_gambiae_AGAP000830-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MSMPDVVDIRNEIN KEHVRESLDRNGDEQQLVQDVNDALGT--------------------------------- ------------------------------------------------------------ ------------------RKGHDPTNHLVRARMPV------------------------- -ERYACDYNMNH---KRRGLALIFNHENFD-VPQ-----------LRSRAGT-NVDCENL -TASLKGLDFE-VHVFKDLKLRDLQKEVERVSQ-MDHS--DADCLLVTILSHGE-L---- ---G-YLYAKDC-Q-------------YKLDTIWTYFTANHCPSLAGKPKLFFIQ--ACQ ----GDQL-DGGV-VLEAKDR------------------------TETDSS-S-SMLTFK IPMYADFMIAYSTIP--GFYSWRNTQKGSWFIQSLCHELNQNG-------RKYDLMVLLT FVTQRVAYD---FESNTPDIP--MMHQ------QKQIPCT-TSMLTRLVYFNQKK----- -------------------------------------------------- >G_gallus_ENSGALP00000014503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKKN----------------- ------------------------------------------------------------ ------------------GEEEQPKSSLSNQYRIV------------------------- -TP-TFQYNMNY---KKVGKCIIINNKNFE-DKT--------G--MGTRNGT-DKDAGDL -SKSFRSLGFD-VYTYNDRSCEDMQTLLKQAAE-ENHS--DAACFACILLSHGE-E---- ---G-LIYGTDG-P-------------MAIKHLTTLFRGDKCKTLIGKPKLFFIQ--ACR ----GSEF-DEGI-QTD-SGPA---------------------N-DTLETD-A-NP-RYK IPVEADFLFAYSTVP--GYYSWRNPGRGSWFVQSLCSVLNEHG-------KQLEIMQILT RVNYVVATN---FESQSD-DP--RFSE------KKQIPCV-VSMLTKELYF--------- -------------------------------------------------- >G_aculeatus_ENSGACP00000007379 ------------------------------------------------------------ --------------------------------------------MEEIHKRILQRNRINL VRDLDPS----------------------------------------------------- -------------------------SLYDGLLEKGVFTQDMIDEIKSAGTRRDQARKLVQ DLETRGSRAFAMLLLCLEETDQHGLAELLQR-AAPAVQIWPAAPN--------------- -----------------------------QPFVLMLNSREKTTSPSIQYRNPVPVHLT-- ---H-------------CDAHVTAPERENTLTRPP--------GRTRR------------ -DS-IQSYKMDA---SPCGHCLIINNVEFE-PDS--------E--LSNRKGS-NIDCDKL -EKRFKALNFI-VEVRTNLKQRQIKHALSALSK-KDHS--QCDCCVVIMLSHGT-EVSHN RFPG-AVYGVDGQH-------------VPVQLITNYLNGQHCPSLQGKPKLFFIQ--ACG ----GGER-DTGF-EVS-P-DEVEPSIGGADDQTDAIPMSSSSD-SLSLSD-EVDA-RAT LPTPSDILVSYSTFP--GYVSWRDTQSGSWYVETLDQVLEQNA-------ATDDLVTMLM MVNHEVSQN-----------S--AKGL------YKQMPGS-FNFLRKLLHFQTHA----- -------------------------------------------------- >D_rerio_ENSDARP00000024255 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EQYEMKG---ERRGVCLIINNYDF--SAC--------G--WLNREGT-DIDHDSL -RDVFEWLGFE-ILTRRDCTGDQILQALMDLST-QDHT--QADCVVCCILSHGR-L---- ---N-DIIGVDGKA-------------VPFKELMETLSPFRCSSLYQKPKLFFIQ--ACR ----GTQN-QRAV-FPQ-TFTEDE---------------------DVLASD-AGVP-RDS IPEMADYLMAMSTVP--WYASYRDKSKGTWFIQSLCDNLRLLV-----P-RGNDLLSILT KVNADVSKK----------SD--KSGL------KKQMPQP-EFSLTRTVVFPPPGLP--- -------------------------------------------------- >G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------QVNGA- RLTSAQDVA--AEEGGPTGDQTDAKPDRRGRFLLFGNIKKNKD----------------- ------------------------------------------------------------ ------------------GQTREQDYSSESHYRVV------------------------- -SP-TFQYKMSH---QRVGKCIIINNKNFD-EKT--------G--MNVRNGT-DRDAGEL -FKCFKSLGFD-VFIYNDQTCGKMESLLREASE-EDHS--DSSCFACILLSHGE-E---- ---G-MIYGTDA-A-------------MPIKSMTSLFRGDMCKSLVGKPKLFFIQ--ACR ----GSEF-DDGI-QTD-SGPP---------------------N-DTLETD-A-NP-RHK IPVEADFLFAYSTVP--GYYSWRNPGRGSWFVQALCNVLNEFG-------KQLEIMQILT RVNYMVATS---FESWSE-DP--RFSE------KKQIPCV-VSMLTKELYFN-------- -------------------------------------------------- >T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAG EAAGIPELGGEAEGEHRCEDDVDAKPDRRGRFLLFKS-KKKND----------------- ------------------------------------------------------------ ------------------GQMREQDYCSESHYRIV------------------------- -SP-TFQYRMSH---QRVGKCIIINNKNFD-EKT--------G--MNVRNGT-DRDAGEL -YKCFKSLGFD-VFIYNDQTCEKMEHLLREASE-EDHS--DSSCFACILLSHGE-E---- ---G-MIYGTDG-A-------------MPIKTMTSMFRGDMCKSLVGKPKLFFIQ--ACR ----GSEF-DDGI-QTD-SGPP---------------------N-DTMETD-A-NP-RHK IPVEADFLFAYSTVP--GYYSWRNPGRGSWFVQALCNVLNEFG-------KQLEIMQILT RVNYMVATS---FESWSE-DP--RFSE------KKQIPCV-VSMLTKELYFKPC------ -------------------------------------------------- >P_pygmaeus_ENSPPYP00000004377 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MA-DKVLKEKRKLFIRSMG EGTINGLLDELLQTRVLNKEETEKVKRENAT-VMDKTRALLDSLIPKGARACEICITYIC EEDSYLAE--------------------TLGLSADQTSGN-----YLNMQDSQGVLSSFP APQA-------------VQDNPAMPTSSGS---KG----------NVKLCSLKEAQKIWK EKP-AEIYPIMDKS-SRTRLALIICNEEFDS--------------IPRRTGA-EVDITGM -TMLLQNLGYS-VDVKKNLTASDMTTELKAFAHRPEHK--TSDSTFLVFMSHGI-R---- ---E-GICGKKHSE--------QVPDVLQLNEIFKMLNTKNCPSLKDKPKVIIIQ--ACR ----GDSH-GVVW-LKD-SVGVS-RNISL--------------P-TTEEFE-D-DA-IKK AHIEKDFIAFCSSTP--DNVSWRHPTMGSVFIMRLIQHMQEYA-------CSCDVEEIFR KVRFSFEQP----------------DG------RAQMPTTERVTLTRCFYLFPGH----- -------------------------------------------------- >C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MADDQDCGMEQAAGDSESPDAVDARPDRSSFVPSLFS----------------------- ------------------------------------------------------------ ------------------RKKKNDSGRSIKTAQDQ------------------------- -VP-TYQYNMNF---EKVGKCIIINNKNFD-KTT--------G--MGVRNGT-DKDAEAL -FKCFRNLGFD-VVIYNDCSCAKMQDLLKKASE-EDHR--NSACFACILLSHGE-E---- ---N-LIYGTDG-M-------------TAIKDLTAHFRGDRCRTLLEKPKLFFIQ--ACR ----GTEL-DDGV-QAD-SGPI---------------------N-D---TD-A-NP-RYK IPVEADFLFAYSTVP--GYYSWRSPGSGSWFVQALCSTLNEHG-------KSLEILHILT RVNNRVARH---FESQSD-DP--HFHE------KKQIPCV-VSMLTKELYF--------- -------------------------------------------------- >H_sapiens_ENSP00000260309 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MA-DKVLKEKRKLFIRSMG EGTINGLLDELLQTRVLNKEEMEKVKRENAT-VMDKTRALIDSVIPKGAQACQICITYIC EEDSYLAG--------------------TLGLSADQTSGN-----YLNMQDSQGVLSSFP APQA-------------VQDNPAMPTSSGS---EG----------NVKLCSLEEAQRIWK QKS-AEIYPIMDKS-SRTRLALIICNEEFDS--------------IPRRTGA-EVDITGM -TMLLQNLGYS-VDVKKNLTASDMTTELEAFAHRPEHK--TSDSTFLVFMSHGI-R---- ---E-GICGKKHSE--------QVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQ--ACR ----GDSP-GVVW-FKD-SVGVS-GNLSL--------------P-TTEEFE-D-DA-IKK AHIEKDFIAFCSSTP--DNVSWRHPTMGSVFIGRLIEHMQEYA-------CSCDVEEIFR KVRFSFEQP----------------DG------RAQMPTTERVTLTRCFYLFPGH----- -------------------------------------------------- >A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --P-TFRYRMDY---KKLGKCVIINNKNFA-KDT--------G--MRIRNGT-DKDAGDL -QKCFRGIGFD-VSIYNDLTCDNMEKILGEAAL-ENHD--DAACFACILLSHGE-E---- ---G-LIYGTDG-C-------------MAIKNLTGLFRGDKCQSLIGKPKLFFIQ--ACR ----GSEF-DAGI-QTD-SGSS---------------------N-DNLEMD-A-NP-RYK IPVEADFLYAYSTVP--GYFSWRNPGKGSWFVQSLCSVLNDHG-------KELEVLQILT MVNYKVARN---YESQSD-DP--RFSQ------KKQVPCV-VSMLTKELYF--------- -------------------------------------------------- >D_rerio_ENSDARP00000071815 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MSDVKPKGVDTVDARQSDAKESSS-------------------------- ------------------------------------------------------------ ------------------VTDPGLVQMDAKSHSDD------------------------- -NV-DYQYKTNY---PNLGQCLIINNKNFH-KRT--------G--MGVRNGT-DEDAKKV -FETFSQLGFK-VGHYNDLTVSQMMALLNKASQ-EDHS--KSAMFACVLLSHGD-D---- ---G-LIYGTDN-S-------------IELKRLFAHFRGDRCTSLVGKPKLFFIQ--ACR ----GTDL-DSGI-ECD-GVG-------------------------------D-EE-TQR IPVEADFLYAYSTAP--GYYAWRNVANGSWFISSLCDMLLKYG-------KQLEIMQVMT RVNHKVALE---FESSSN-LP--GFDG------KKQIPCI-VSMLTKELYFPK------- -------------------------------------------------- >E_caballus_ENSECAP00000021890 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------T-GNVLKEKRRLFIRSVG TGTVNSLLDELLEKRVLNQEEMEKVRDENAT-VMDKARALIDAVIRKGPQACQIFIGHIC EDDPHLAE--------------------TLRLSSGPQSGN-----FLKTQDSQAVVHSSP ALQA-------------MPDDLAKLALSGP---KV----------SLKLCSPEVVERIWK EKS-AEMYPIMGKSMTRTRLALIICNTEFDN--------------LSRRAGA-EVDIASM -KVLLEGLGYS-VEVKENLTALDMTTELKAFAARPEHR--SSDSTFLVFMSHGI-R---- ---E-GICGKKFSE--------KVPDVLEVNTIFQIFNTRNCPNLRDKPKVIIIQ--ACR ----GENQ-GVVW-LKD-STGTS-GSSSS--------------L-APDDFE-D-DA-IKK AHVEKDFIAFCSSTP--DTVSWRSPTTGSVFIEKLIENLQEYA-------WSCDLEEIFR KVRLSFELP----------------DA------RAQMPTAERVTLTRRFYLFPGY----- -------------------------------------------------- >T_guttata_ENSTGUP00000011206 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKKN----------------- ------------------------------------------------------------ ------------------GEEEQPKPSLSNQYRIV------------------------- -TP-TFQYNMDY---KKVGKCIIINNKNFE-DKT--------G--MGTRNGT-DKDAGDL -AKSFKNLGFE-VDIHHDRSRDDMEKLLKKAAE-ENHS--DAACFACILLSHGE-E---- ---G-LIYGTDG-P-------------MAIKSLTALFRGDKCKSLIGKPKLFFIQ--ACR ----GSEF-DEGI-QTD-SGPA---------------------N-DTLETD-A-NP-RYK IPVEADFLFAYSTVP--GYYSWRNPGRGSWFVQSLCSVLNEHG-------KQLEIMQILT RVNYVVATN---FESQSD-DP--RFSE------KKQIPCV-VSMLTKELYF--------- -------------------------------------------------- >G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MDKLYRDVQSG------------------------- -ED-KYRYKMDY---PCMGTCVIINIKNFD-LKT--------G--LETRNGT-DVDAAEL -EKTFSKLGYK-VTLVHDQTADQIVDLLRDVST-QDHS--NSGSFVCVLLSRGD-E---- ---G-GIYGTDGSF-------------VNLDELTKFVDGNGCRSLVGKPKLLFIQ--AAR ----GNKL-DDGT-LSE-GDS----------------------------MD-G-QT-PSR IPVEADFLYAYSTTP--GFNAWRDTQNGSWFMQSLCEMLRRFS-------GQLELMQIMT RVNNKVALE---YKT----TP--GRSG------KRQMPCI-VSLLTKEFYFP-------- -------------------------------------------------- >A_aegypti_AAEL014348-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------MKKIMFGRKE----------------------------- ------------------------------------------------------------ ------------------VNSPQQMIPTVAPAYTI------------------------- -ERYSAYYPMNH---KHRGKAIIFAHSVFAVKNV--------N--LPNRDGS-DVDCEML -VESLKRLHFD-VTLYKDYRLKDILLVIEKVSL-MDHS--NSDCLLVAVLSHGD-E---- ---GEVIYAHDC-P-------------YQISSIWTQFTGDRCRTLVGKPKIFIIQ--ACR ----GNDL-DSGV-KVE--------------------------------KD-G-VA-RYS IPTNADFLFAFATIP--GYMSFRNTKNGSWFIRELCNELNENG-------QRYDMLTLLT FVVQKVAYG---YESYAPVHP--DHHM------KKQTPCV-VSMLTRLLLFNNV------ -------------------------------------------------- >X_tropicalis_ENSXETP00000017024 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LA--AQLKKVRKLFIDGCN AAIINNLLDDLLDKSVLTDSEVEYINECNAI-TKDRCRRMIDNIKNKGDYSSNILLQCLV ENHKTLAK--------------------NMGLDVSEPA---------------------I APQP-------------IQEQNKKTNENTE---IS----------SVIHCSDKDFKEIHD TQG-DKIYEMRKRE-GRKRFALIICNEKFET--------------LTERQGA-KVDLDGM -TKLLNELGYQ-VLQETNLAKEEMLKVLKEFAAREEHV--DSDSTFIVLMSHGD-K---- ---P-GVCGTDSKKIEHEKGQCQVTNLLQTDEIFSIFNNIHCPKLRDKPKVIIIQ--ACR ----GEER-GQKL-VCD-AV-------AL--------------P-PEEQLE-D-DA-LHR VQRETDFICFCSSTP--DTVSWRHPTMGSLFITGLIKKMNELA-------HCQPLMDIFL EVQSSFKG-------------------------QRQMPTQERSTLTKKFYLFPGH----- -------------------------------------------------- >O_latipes_ENSORLP00000014046 -----------------------------------------------------------M D-RRTLSRIDDELNSEEVAELCFLCTDFIPRKRLEGISSAKDLFLKLEDATLL-DSS--Y LTQLFRTIHREDLVRQVQNGSRQAEEADAVPS-------LSDY----------------- ---------------R---------VMLYSIHDD--MTEENLDKLKFLLNPKLNRRPLEK SKTALDVFVEMEKSQLISKDDVSGLYKLLLE-FDKKLAAVVEKYM--------------- -----------------------QDHRGALTDTSHYQKRPSIPSLE-SLSVSQPETWS-- ---E--------------TEDPNNGVRSDATPCPD--------PPTSP------------ -DE-EEYYSFTH---EPRGLCVIFNNKLFF-PES--------N--LGERGGT-EKDEKSL -NNLFHRFGFE-VVVHNNLTADLIESEITKLGQ-RNFS--HDDALVVCVLSHGD-N---- ---G-CVYGIDGKK-------------VQLRALTLPFTSYRAPSLIGKPKLFFIQ--ACQ ----GTLD-QSGY-LPG-S-EVKG------D------------A-ELEADA-SSST-SNS VPNDADFLLGMATVA--ECKSFRNKYTGSIYIQELCRQLERAA---ESS-KMEDILGVLV HVNREVSKG----------VF---LN-------KKQMPEP-KYTLTKKVVLKYMN----- -------------------------------------------------- >D_rerio_ENSDARP00000019984 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MDKEALTSENEVSGDDQENYGKGDVTDAKPDPKAMCRVDKE- ALTSEIEVLEEDQDSYGEEDVTDAKPDRKGRFRLFGN-FKKND----------------- ------------------------------------------------------------ ------------------GKLQEKG-ESESHYRIV------------------------- -SP-TFQYKMSH---QRVGKCIIINNKNFD-EKT--------G--MNVRNGT-DRDAGEL -FKCFKSLGFD-VAVYNDQTCRNMERLLKAVSE-EDHS--DSSCFACILLSHGE-E---- ---G-MIYGTDG-A-------------MPIKTMTSLFKGDVCKSLVGKPKLFFIQ--ACR ----GSEF-DDGV-QTD-SGPP---------------------N-DTIETD-A-NP-RHK IPVEADFLFAYSTVP--GYYSWRNPGRGSWFVQALCNVLSEFG-------KQLEIMQILT RVNYMVATS---FESWSE-DP--RFSE------KKQIPCV-VSMLTKELYFN-------- -------------------------------------------------- >T_nigroviridis_ENSTNIP00000010722 -----------------------------------------------------------M D-LQLLSRICEQLDSQEVASLCFLCREAVSKKSLEGINDARGLFKKLADQCLLENNS--F LRQLLQTIRREDLLRLLGADNRQLMETDASPL-------LSGYS---------------- -------------------------VMLYNIYED--LCKEDLGKIKFFLGDKLGRRPTEM CKTVLDVFAEMEKKGFLSEIYLDELHSVLQN-VNPLLASKVQQHM--------------- -----------------------QHLRDNHRPVAALPSDPA------QVRLPVRETQ--- ------------------LRDVEQNLFSDAEPAVR--------PSRTA------------ -ND-TEYYSLTH---KPHGLCVVFNNEFF--PRT--------G--LRERAGTIEDDADSL -RAVFTKLGFT-VVVHKDLTATDIERELQRLAN-RNFV--NEDALVVCVLSHGQ-K---- ---G-CFYGTDGAT-------------VKIQDVTQPFTSTRVPTLAGKPKLFFIQ--ACQ ----GDDL-QMGC-VPC-P-PRPAQNVDMEQ------------S-RLEEDA-GFVR-GET VPDGADFLLGMATVQ--DYKAFRNTTTGSIYIQELCSPVTKSA---ESS-EQDDILSILT RVNREVSKG----------VF--QWR-------KKQMPEP-KYTLTKKLVLKLD------ -------------------------------------------------- >T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------SMQMAG EPTEISDLGGEVEEGGQSEDDVDAKPDRKGRFLLFKS-KKNKD----------------- ------------------------------------------------------------ ------------------GQMREQDYCSESHYRIV------------------------- -SP-TFQYKMSH---QRVGKCIIINNKNFD-EKT--------G--MNVRNGT-DRDAGEL -FKCFKTLGFD-VFIYNDQTCEKMERLLREASE-EDHS--DSSCFACILLSHGE-E---- ---G-MIYGTDG-A-------------MPIKTMTSMFRGDMCKSLVGKPKLFFIQ--ACR ----GSEF-DDGI-QTD-SGPP---------------------N-DTMETD-A-NP-RHK IPVEADFLFAYSTVP--GYYSWRNPGRGSWFVQALCNVLSEFG-------KQLEIMQILT RVNYMVATS---FESWSE-DP--RFSE------KKQIPCV-VSMLTKELYFKQC------ -------------------------------------------------- >M_domestica_ENSMODP00000036247 -----------------------------------------------------------M DFHTFLYGIAEEIDSADLASLKFLCLDQIPLKKQQHIKDALVLFQTLEERGLLEEDNLFF LKELLFRINRIDLLNEPLNTKGPEMERELQVPNKAR---ISPYRLHLHTTIWPFRDNWTC RITLSVSFTS-----RTKQLLSVMVILLFNLSEG--VGPSELKSIKFMLSSKIPKCKIED DMTLMDLFIEMEKRGILGEGNLDALKIVCDQ-IDKSLLKKIQEYEISK------------ ------------------------------------------------------------ ------------------GRNNLFLIYQNTQPQEV---------------------YDSA GEK-GNVYKMSS---RPRGYCLIINNFDF--KISRKERPENHY--LTDRRGT-NKDEEAL -KNIFKELHFD-IQSFQDLTAEGIQQVLKTFKD-NNHE--SKDCFVCCLLSHGN-K---- ---G-TIYGIDGKE-------------VPIRDLTSYFSGSNCPSLAGKPKVFFIQ--ACQ ----GKAT-QYGI-SLD-TDSEQQ-------------------R-ESLEAD-KSFQ-SEC IPNEADFLLGMATVE--NYVSYRDSARGTWYIQSLCKNLKEGC-----L-RGNDILTILT EVNSEVSQK----------TD--PKNN------GKQMPQP-KITLRKKLVFPIS------ -------------------------------------------------- >A_carolinensis_ENSACAP00000013788 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----DHYGMKK---KRVAFMMCV---------------------TEGRAGA-EEDIKKM -KKWFRTFKFTLLGDCRNPGQETLMQQLRQFRDIINLSNEEISCCLITLMSHGKAN---- ---G-YILDKDNRE-------------ISLDGIFSLFNNKTCPKLQGKPKIFIIQ--ACR ----GEQR-DYGT-LVA-G------------------------G-KPVEPD-T-WS-RPK LPTVSDYFIVYSSQR--DHIAVRDENTGSEMISAMDEVFSEHG-------TQWHIGDLFT KVNSKMIQR--------------DFHLEGEEESVKVTIVM-ESTLTKALYL--------- -------------------------------------------------- >M_mulatta_ENSMMUP00000012901 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------T-DKVLKEKRKLFIHSMG EASL-------------------------------------------------------- ------------------------------------------------------------ ---A-------------MQDNPAMPTSSGS---KG----------NVKLCSQEEAQRIWK EKP-AEIYPIMVKS-GRTRLALIICNEEFDT--------------LPRRTGA-EVDITGM -TMLLQNLGYS-VDVRKNLMASEMTTELEAFAHRPEHK--TSDSAFLVFMSHGI-R---- ---E-GICGKKYSE--------QVPDVLQLNVIFEMLNTRNCPSLKDKPKVIIIQ--ACR ----G------------------------------------------------------- -----------------DNVSWRHPTKGSVFIIRLIEHIQEYA-------CSCDVEEIFR KVRLSFEQP----------------SG------RVQMPTTERVTLTRCFYLFPGH----- -------------------------------------------------- >E_caballus_ENSECAP00000010831 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MA-EDRQERNLLKTLESVG KELITGLSVGLVEKDVLKLKEEERKKFYEAK-PGDKPWVLVDSVRDRRHEAGQILWQALF NIDRSVIS--------------------------------------------RKALEEIA AGPA---------------------ESAEP---TD----------TLKLCPHEEYLRLCK ERA-EEIYPIKDKK-DRTRRALIICNTEFDH--------------LPFRTGA-DFDLSGM -KRLLEDLGYS-VDVKEQLTATDMESVLREFAAHQDHR--SSDSTFLVFMSHGI-L---- ---D-GICGTTHSD--------EKPDVLPYDTIFRLFNNRNCPSLKDKPKVIIVQ--ACR ----GANR-GELW-IRD-CLAAL----------------------APENLE-E-DA-VYK THVEKDFIAFCSSTP--HNVSWRDITKGSLFITQLITCFQRHS-------WCCHVEEVFR KVQQSFEKP----------------SI------KTQMPTTERQSMTRYFYLFPGN----- -------------------------------------------------- >P_troglodytes_ENSPTRP00000059619 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MA-DKFLKEKRKLFIRSMG EGTINGLLDELLQTRVLNQEEMEKVKRENAT-AMDKTRALIDSVIPKGAQACQICITYIC EEDNYLAG--------------------TLGLSADQTSGN-----YLNMQDSQGVLSSFP APQA-------------VQDNPAMPTSSGS---EG----------NVKLCSLEEAQRIWK EKS-AEIYPIMDKS-SRTRLALIICNEEFDT--------------IPRRTGA-EVDITGM -TMLLQNLGYS-VDVKKNLTASDMTTELKAFAHRPEHK--TSDSTFLVFMSHGI-R---- ---E-GICGKKYSE--------QVPDVLQLNAIFNMLNTKNCPSLKDKPKVIIIQ--ACR ----GDSP-GVVW-FKD-SVGVS-GNLSL--------------P-TTEEFE-D-DA-IKK AHIEKDFIAFCSSTP--DNVSWRHPTMGSVFIGRLIEHMQEYA-------CSCDVEEIFR KVRFSFEQP----------------DG------RAQMPTTERVTLTRCFYLFPGH----- -------------------------------------------------- >D_melanogaster_FBpp0084848 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MDATNNGESAD QVGIRVGNPEQPNDHTDALGSVGSGGAGSSGLVAGSSHPYGSGAIGQLANG--------- ------------------------------------------------------------ ------------------YSSPSSSYRKNVAKMVT------------------------- -DRHAAEYNMRH---KNRGMALIFNHEHFE-VPT-----------LKSRAGT-NVDCENL -TRVLKQLDFE-VTVYKDCRYKDILRTIEYAAS-QNHS--DSDCILVAILSHGE-M---- ---G-YIYAKDT-Q-------------YKLDNIWSFFTANHCPSLAGKPKLFFIQ--ACQ ----GDRL-DGGV-TMQ-RSQ------------------------TETDGD-S-SM-SYK IPVHADFLIAYSTVP--GFYSWRNTTRGSWFMQSLCAELAANG-------KRLDILTLLT FVCQRVAVD---FESCTPDTP--EMHQ------QKQIPCI-TTMLTRILRFSDKQLAPAG RV------------------------------------------------ >O_anatinus_ENSOANP00000002508 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MADDQAPTMHQKECDFEDEVDAKPERLKVAQLF---SKKKN----------------- ------------------------------------------------------------ ------------------EAESQSGGPLPVRNRVV------------------------- -SS-SFIYNMKY---ENLGKCIIINNKNFA-SKT--------G--MSTRNGT-DKDAGNL -QKCFRSLGFD-VSVFNDFSCNQMKEILQKASE-ENHE--NSACFACILLSHGE-G---- ---D-CIYGTDD-F-------------IPIKELTILFRGDKCKSLLGKPKLFFIQ--SCR ----GTEF-DDGI-QTD-STPV---------------------T-D---SD-A-NP-GCR IPVEADFLFAYSTVPVKGYYSWRNVDRGSWFVQALCSVLHEHG-------KELEIMQLLT RVNHQVAIN---FESQAS-DP--RYCQ------KKQIPCL-VSMLTKELYF--------- -------------------------------------------------- >X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------STKKKK----------------- ------------------------------------------------------------ ------------------TEDPEKPPQASDNVRIV------------------------- -TP-AFQYKMNY---GKVGRCIIINNKNFD-DIT--------G--MSPRNGT-DIDARDL -LRCFKGLGFD-VTVFNNKSCTEMETLLRSVAE-QDHK--DSACFACIFLSHGE-E---- ---G-LIYGTDG-A-------------MPIKVLTTLFRGDKCRSLVGKPKLFFIQ--ACR ----GCEF-DDGL-ETD-AGPS---------------------N-DSLETD-A-NP-RHK IPVEADFLYAYSTVP--GYYSWRNPGRGSWFVQALCNVLNEHG-------KELEVMQILT RVNYLVATQ---FESYCD-DP--QFNK------KKQIPCV-VSMLTKELYFKPC------ -------------------------------------------------- >D_melanogaster_FBpp0113052 ------------------------------------------------------------ ------------------MAGSNLLIHLDTIDQNDLIYVERDMNFAQKVGLCFLLYGDDH SDATYILQKLLAMTRSDFPQSDLLIKFAKSRPETWRRHLVEALCIIGARKVLRRLGFCWQ ELRMHYLPHIAGITLHVHPLLKSLYRMCEELSLVQSGRLLLDVREKVESQQAGDPLRFYD PAYLEIFLLDWLTRRSIKLGDINAAGSDVQL-LVGHLK---------------------- -------------------------------------------------SNGLQAQAN-- ---L-------------LKDTIISNAPEPDAAGTA--------AMAVKQEIESDNQQSYC STQ-IDALKLTR---ENAGIALIINQQKFHRNVSRDNMKFLSPDPLRRRDGT-DVDKERL -IEVFSSMGYN-VEAYDNVDHMGIIERIRSACD-RSLV---RDSLVVFILSHGF-E---- ---E-AVYASNSIA-------------MKITDIEDLLCSY--DTLYYKPKLLIIQ--ACQ ----EKLV-HKKK------------------------------P-NELFRI-D-VT-TVS PDQHIDMLRAMSTVN--GYAALRHTQTGSWFIGSLCDAIDRRS-------ASEHIADILT IVTNEVSKK-----------R--GSND------ESMVPNV-KSTFRQHVYFPPRL----- -------------------------------------------------- >O_cuniculus_ENSOCUP00000011835 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MSSAPGLRGAR---------- -LAG-------------GKQNMTETDAFYK-REVF------------------------- -DP-AEEYKMDH---RRRGIALIFNHERFF-WHL--------M--LPERRGT-NADRDSL -ARRFSDLGFE-VKCFNDLKAEELLLKIHEVST-SSHL--DADCFLCVFLSHGE-G---- ---N-HIYAYDA-K-------------IEIQTLTGLFKGDKCQSRVGKPKIFIIQ--XXX ----XXXX-XXXX-XXX---XXXXXXXXXXX------------X-XXXXXX-X-XX-XXX LPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFTELLT LVNRKVSQR---RVDFCK-DP--SAIG------KKQVPCF-ASMLTKKLHFFPK------ -------------------------------------------------- >A_gambiae_AGAP011952-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ENYDTSH---RNRGTALIFNHVNFE------------S--NAKREGS-NKDRDEI -KKELLQLGFD-ARVFNDLKKQELLAKLDEVAK-EDHT--ESDCFVLVMMTHGQ-D---- ---G-SLYAADK-Q-------------YQIAELWEPFVGDACKTLIGKPKLFFVQ--ACR ----GTKF-DKGV-KLT-KIATD--------------------T-VDALSS-SSQR-TCV IPTMADVLVMYSAFD--GHYSWRNPTHGSWFIQSLSIELNQHA-------HRKELLQLLT SVSRRVAYL---YESNVPGNE--QMDG------KKQMPCV-VSMLTKALYFPRK------ -------------------------------------------------- >G_aculeatus_ENSGACP00000016969 -----------------------------------------------------------M D-RLKLSRIDEDLESSEVASLCFLCRDVLARKRLEGINNARDLFLRLEENGLLENNS--F LFELLQTIRRTDLLNLLESDSSPPEEADANPI-------LSDYR---------------- -------------------------VMLYRVDQD--ITRENLSMMKFLLSSQLGKRQMEM CNTALDVFAEMEKTGSLSPTSLHEVHAAVKQ-FDQQLALTIQRYI--------------- ------------------------------DNRGTATPRPHRPIHPQPVDVSISETQSNC ------------------SSDEGMNICSDAEPNTK--------PSSPD------------ -DH-TEYYALIH---KPRGLCVVINNEDFL-GTQ-----------MKNRKGTQEDDTEAL -CSLFSRLGFT-MLVHNNLTAGAMKQELQKLGA-RNFV--NDDALVVCVLSHGE-M---- ---E-CVFGTDEQR-------------VNITDLTRPFTSEGAPTLAGKPKLFFIQ--ACQ ----GTRY-QGGS-LPH-P-SLPGQEEGVPQ------------S-PLEEDA-GPIK-GET VPWEADFLLGMATVP--QCKSFRSTTTGSIYIQEVCTQLKKSA---ESS-ANDDILTVLT RVNREVSKG--------------KYLN------SKQMPQP-KYTLTKKLVLKYV------ -------------------------------------------------- >D_rerio_ENSDARP00000075650 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MDKKESVDKICENKIFLLETL SVDANFILQHVQQAKLITLRDYNNLSDFPQR--ETKIINLLDKLMGKGEETCHQFIALLR QDCV-------------------------------------------------------- ------------------LENFPMLKDHDIFDSSV------------------------- -QE-ISPYRIIK---NPRGICVIINNEIF--SSG-----------MMSRRGS-DKDREYL -AKVFHWLGFE-VVEHNNKDTAEIRNILKDLGR---TV--DGDCFVCCILSHGR-R---- ---E-GVCGTDGNY-------------LSIDEIRDPFTGVKCQKLVGKPKLFFIQ--GCR ----GANSLQACV-KVE-ADA---G------------------N-SKAKVE-GDNL-DIT IPSDTDFLIARSTTN--GHVSYRHVREGSWFIQSLCRNLEKHC-----P-RGADILTILL YVNNEVSSQ---------------KSI------RKQMPIY-EVALTRKLFLRPVNP---- -------------------------------------------------- >D_rerio_ENSDARP00000063081 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MSKKESTQRILQHKVFLIDTL SVEASFILQNVQQAKLITQRDYNNLSDVSER--ETKIIKLLDKLIGRGEETCQEFIDLLR QDCV-------------------------------------------------------- ------------------LENFPVLEGHAIFASSV------------------------- -QK-VSQYKITQ---NPRGICVIINNVDF--TS------------MGERRGS-DEDQNYL -AKVFRWLGFE-VVAHRNKTAAEMKNILQALGR---TV--DGDCFVCCVLSHGV-E---- ---E-GVCGTDGSL-------------VSVDEIRNPFTGVNCQKLVGKPKLFFIQ--ACR ----GQRK-QLRV-NAQ-ADGPGDG------------------E-SEMEVD-GDDF-DIT IPSDTDFLIARSTTD--GHVSYRKPDEGSWFIQSLCRNLEKHC-----P-LGADILTILL SVNNEVSIQ---------------GLH------SKQMPVH-EVAMRMKLILPPVNN---- -------------------------------------------------- >C_intestinalis_ENSCINP00000011503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------MERMSDETPRKPAAG DVLKIYKSEVKRNATSESDENIDAISDSSDD-F--------------------------- ------------------------------------------------------------ ------------------YKDDDDDGKGLVPTVLR------------------------- -QH-MLEYYMKN---ERRGTFVVFNQENF--DRM-----------RHPRKGS-GVDVEML -VKSANKLGFEDVRVLKNQTTDEIRDHLQELSY-QDHS--NCDCFVCVVLSHGE-S---- ---DGVLYTKDG-D-------------IHLKEILDSFKASRCPSLAGKPKLFFIQ--ACR ----GEKR-STPV-EIE-YKFDVTD------------------S-TPPEEQ-T-TT-VFT IPAEADFLIAHATPE--EFCAWRNRREGSRFIKALCGCLDRYA------GDDIELLQILT VVNHHVSHG---WDGEVY-----KYEK------SKQIPSI-TTQLTAQLFFTKKSKNKIC QEKPQGTIKENENANAQANDDFIAHEGQETEKEISRPIPSPRHKKTETQV >P_troglodytes_ENSPTRP00000047678 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MADEKPSNGVLVHMVKLLI KTFLDGIFDDLMENNVLNTDEIHLIGKCLKF-VVSNAENLVDDITETAQIAGKIFREHLW NSKKQLS----------------------------------------------------- ------------------------------------------------------------ ----SDISSDGER--GANMPGLNICNKEFNY--------------LHNRNGS-ELDLLGM -RDLLENLGYS-VVIKENLTAQEMETALRQFAAHPEHQ--SSDSTFLVFMSHGI-L---- ---N-GICGTKHWD--------QEPDVLHDDTIFEIFNNRNCQSLKDKPKVVIMQ--ACR ----GNGA-GIVW-FTTDSGKASADTHGR--------------L-LQGNIC-N-DA-VTK AHVEKDFIAFKSSTP--HNVSWRHETNGSVFISQIIYYFKEYS-------WSHHLEEIFR KVQHSFETL----------------NI------LTQLPTIERLSMTRYFYLFPGN----- -------------------------------------------------- >P_pygmaeus_ENSPPYP00000004372 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------FTDEKPSNGVPVHMVKLLI RTFLDGIFDDLMENNVLNTDEIHLIGTCLKF-VVSNAENLVDDITQTAQIAGKIFREHLW NSKKQLS----------------------------------------------------- ------------------------------------------------------------ ----SDISSDGER--GPNTPGLIICNKEFNY--------------LHNRNGS-ELDLLGM -QDLLENLGYS-VVIKENLTAQEMETALRQFAARPEHQ--TSDSTFLVFMSHGI-L---- ---N-GICGTKHWD--------QEPDVLHDDTIFEIFNNRNCRSLKDKPKVIIMQ--ACR ----GNGA-GIVW-FTIDSGKASADTHGR--------------L-LQGNIC-N-DA-VTK AHVEKDFIAFKSSTP--HNVSWRHEINGSVFISQIIYYFKEYS-------WSHHLEEIFR KVQHSFENP----------------SI------LTQLPTIERLSMTRYFYLFPGN----- -------------------------------------------------- >A_carolinensis_ENSACAP00000001629 ------------------------------------------------------------ -FRQILLAIDENLGKEDVDAMKFLCSDFISTKHLEGVETAQDIFQLLINRNLLSKEDTFI VAELLYRIKCHFLLQK-IGYTQQKVEHNLFHIRN-----VSEYR---------------- -------------------------QMLYEISEG--FTEENVKTAMFLLREHLPKKQ--- -SIAVKLLTSLEKQDLLAEDKLAILEKICNK-VSPELRNKVDKFKERSVFKAFVFSLC-- ------------------------------------------------------------ ------------------YENLYPSNFLAVFLLIL------------------------- -QA-STCYKMDG---LNRGSCLIFNNVHF--EGG-----------LSQRRGS-QKDAEEL -ESVFRWLGLD-VIKYNDTTSIEMENHLKQWQSFENWK--DMDCLVCCILSHGE-S---- ---G-KIYGTDGNL-------------IPIRTIMSYFTAKQCPQLAKKPKLFFIQ--ACQ ----GEKT-QQPV-YLE-TD-----------------------D-EYGSFP-LQQM-ISS IPEEADFLLGMATVD--GYLSFRHVHQGTWYIQALCDKLRTLV-----P-RGEDILSILT EVNADVSRR----------AD--AQGQ------KKQMPQP-AYTLRKKLIFPIP------ -------------------------------------------------- >E_caballus_ENSECAP00000004055 -----------------------------------------------------------M NFNSCLYNIGEQLDSDELASLKFLSLDHIPQRKQEPIQDALMLFQRLQEKRLLEESNLSF LKELLFRINRLDLLTTELDTSKEEMERELQSPGRAQ---ISAYR---------------- -------------------------VMLFQISED--VNKLELKSFKFLLSRELPKCRLDD DMILLDIFIEMEKRVMLGERNLDTLKKICEQ-VNKSLLKKINDYEELSREGRISLERSPD EFSNASLKCLQ------------------------------------------------- ------------------REGSLAGQAMSDSPGQQ---------------------NSES QTS-DKVYRMES---KPRGYCLIFNNHDF--SAARRDVPKLQN--IKDRNGT-DLDAEAL -SMTFTELHFE-VVPYKNSTAKDICDALREYQE-MDHK--KKDCFICCILSHGD-K---- ---G-IIYGCDGQE-------------ASIYELTSYFTGSNCPSLAGKPKIFFIQ--ACQ ----GDNY-QKGI-AVE-TDSELT-------------------D-AYLEMD-SSFQ-KRC IPDEADFLLGMATVN--NCVSYRNPLEGTWYIQSLCQSLRERC-----P-RGEDILTILT NVNFEVSSK----------DD--KKNM------GKQMPQP-TFTLRKRLVFPLN------ -------------------------------------------------- >A_gambiae_AGAP011949-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------MDSILEFE------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----LKSYDTTH---PNRGIAVVIND-------------------SERREGS-EKDVQDV -VATLEGLKFN-VRTFQDNTKKEIKKALYKVAR-EDHN--ENDCLVIVAMAHGK-K---- ---D-HITLKKE-K-------------LRIDKLWASFVGNKCPSLIGKPKLVFIQ--TCR ----GDNV-DFGV-ASH-ET-----------------------D-STPCSV-D-PA-PGI IPMYADLLVMYSSYD--RHISVRCKDKGSWFIQSLCQVLRANI-------AGKELISLLT QVSYIVSCQ-------TSITS--DGET------VKQIPSI-NSMLTKAFYFVPKQTQQIS -------------------------------------------------- >C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------KYKMNH---KERGCFMIFNQEVYD-AKT--------SLNLGERIGS-STDARNL -ASAAAYLGFEYIQVFNNLTRSKILKWLKDVAA-ASHE--SYDCFGCAILTHGD-K---- ---NNELYARDA-S-------------MNITDFTNPFTADKCPTLAGKPKLFFVQ--ACR ----GHKR-DTAV-PF-------------TL------------N-VASTIE-K-TE-LKL IPCQADFLIASSTPE--GYSSWRNKANGSWFIQALYLCIQRYP--------SLEIMQIMT RVNRMVALH---FENTN--TE--SPDI------YKQIPSI-CTRLTGELYFHKPGST--- -------------------------------------------------- >C_familiaris_ENSCAFP00000021904 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VLTGKRQSQDPVNAIKVVA STMLNSFLEDLKEKNVLNKQELQTMGQTVNV-ITKKTENLVGDLTEKTQVVGKIFKDHFL NSGSLLSL-------------------SWSSTSATKPSGS-----CRPSYLTQARSRKKE EVPKILVFVIFLYKMVFLLQVLQEIQASQ----VK----------VRKLCPCDHSHEPKI TNV-HEIYPVMEKE-GRTRLALIICNSEFDY--------------LSKRQGS-EIDILGM -QDLLENLGYS-VVVKENLSALEMKTELKNFAARQEHK--FSDSTFLVFMSHGT-L---- ---D-GICGTKHRN--------EEPDILHDDTIFQIFNNRNCRSLKDKPKVIIMQ--ACR ----GRGD-GAVW-VTD-VGEASAWTCDQ--------------P-LQCYIF-N-DA-IEK THVEKDFIAFKSSTP--HNVSWRLNTDGSLFISHLIHYFREFS-------CCHHLEEIFR KVQNSFETP----------------NT------MIQMPTIERVSMTRYFYLFPGN----- -------------------------------------------------- >G_aculeatus_ENSGACP00000016983 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MSARGKVRSQKTAIHEAL CADYSLILNKVFEKGLITPREYRNLKSINKESVEGHVIELVDKLLDKGEDTCEAFLSLLQ TD---------------------------------------------------------- ------------------DDIVKTYPALRTLQLDDRGTLHAPVQDTSVGHSDVRPPPSKK LKK-DERYELNS---QPSGLCVIINNKNF----------------SKPRRGS-DKDAESL -GEVFTWLGFR-ALMCKDQTKDQMERALNKFTA-LQEAPRHGDALICCILSHGR-K---- ---G-VVLGIDDQP-------------LSIKQIIGTFLPPANTTLTGKPKVFLIQ--ACQ ----GGQA-QHGV-FEE------------------------------LQAD-D-SP-SPT IPKEADVLVAVATVE--DYLAFRHITDGSWFIQSVCEQLKDGC-----P-RGEDITTILQ RVNWEVGKK----------EGCSAPGA------GKQMPEV-RFTLRKKLVLSPHPNCFVA K------------------------------------------------- >C_intestinalis_ENSCINP00000025905 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------TDAGGFD--------------- -----------------------------------------------PGSEGTITE---- ------------------IGDTDQNETIKRGFISL--------DELGE------------ -NF-DFCYNMQH---KKRGLFVVFNQMKFD-KHL--------K--LSERTGS-DKDAAAL -LKTAELLGFE-TEEYLDLERKQIRRKLYELSE-MDHG--DHDCFACAILTHGG-K---- ---DNILYSHDD-E-------------MKLKDFTTPFEADKCRSLASKPKLFFVQ----- ------------------------------------------------------VA-SFT LTFVNAFLVCFELRHTYYYYAWRSSDKGSIFIQTLCSVFERYS-------DEMDIMKILT RVNRVVAFN---FESWTQ-RP--DMNH------MKQIPSI-TSQLTAELFIK-------- -------------------------------------------------- >C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------ EFRLLLHQICEGLTGENVSMMKFLCKDAIPRSR--ELETALDFMEYFEAKGWIQEGDLGF LAEVLYRINRHDLLKLLPGVKNRRDYEENFQAQQNNFTTYR------------------- -------------------------VVCFMLADE--LTEGDLKILKRLCAGKMSKANVRR SVDVLSWLTCMEEEDLLSEGDLDFIMSILQH-LDNQKPYKLFQRV--------------- -----------------RMNDNTVTLPKNQQKSNAFQPNSHLPVASGFNSLSKQEYNH-- ---T-------------SKLEPQYVSMENHRAFNG--------GYNQYNNYQSEIKDTST MGI-LDKYPM-----ERRGYCLIINNENFE---------------RQDRTGS-GNDTERL -ENLFKEFGFI-LDVRKDLDQREMEKVIQEYTK-KDHS--DKDCFVCVVMSHGL-S---- ---G-CVYGVDGLS-------------LSTSKISKSFRPGMCSSLTGKPKIFFFQ--ACQ ----GDRT-MDGH-SAP-V-D----------------------D-VESDGA-ASHG-RQV LPSESDFLIGHSTVP--GYLSYRSRTDGSWFISTLVDSLEKYH-------EKEDLLSIMI NVNQEMASK-----------P------------YKQMPMP-IATLRKKVFFSKQNSNSSS NQNCNTP------------------------------------------- >T_guttata_ENSTGUP00000010625 ------------------------------------------------------------ DFRKLLFEVSEALVTEELSALKFLSLDHVPRRKLEAIHEPKAFFEVLQEKDMIGAGNLFF LKELLYRIHRIDLLSTPLGCSREEMERELQLPGRAQ---VSAYR---------------- -------------------------QLLYGIAED--LTSEDVRSVKFLLQKQLPKNKLQE NASMLQVFLEMEIKGIIKEDNMTTLKDILQR-FRADIKKKIDAYEEKKKGLTGSAEVSLE LPVSWI------------------------------------------------------ ------------------DSVDHIKQSTLGLPGED---------------------RSLS FQL-LEAYKMTS---RPCGVCLILNNHNF--AKAREGVLEHKH--MKDRNGT-DVDAAAL -RNVFSKLHFR-VEEYRDLTAEEIRETVNIFQS-ADHE--DKDCFVCCILSHGK-K---- ---G-IIYGVDGQE-------------VPIRELTTSFTAQNCSSLAGKPKVFFIQ--ACQ ----GDAF-HKGV-AIE-TDSVEE-------------------D-SSLERD-ARFQ-LDC IPAEADFLLGMATLQ--DYVSYRSPKEGTWYIQALCQHLEYSC-----P-RGEDVLTILT AVNQEVSKK----------TC--ERDA------KKQMPQP-SFTLRKRLIFPVN------ -------------------------------------------------- >A_gambiae_AGAP011951-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ECYDTSN---ARRGIALIINQVIFS------------S--MAVRVGS-SKDRTDI -STVLQRIGFE-VRVMDDPNRKQLLSALKQLAG-EDHS--HSDCLVVVVMTHGK-E---- ---NNLLYASDK-S-------------YEANQLWEPFIGDACPSLIGKPKLFFVQ--ACR ----GKKL-DEGV-IQA-TISID--------------------S-VDTQSS-PGSM-RYV IPAMADLLVMYSTYD--GHYSWRNPSKGSWFIQSLCAELGASA-------HCKELLHILT AVSRRVAYH---YQSNVPDNA--KIDA------KKQMPCM-VSMLTKLLYLRPKK----- -------------------------------------------------- >R_norvegicus_ENSRNOP00000009993 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MA-DKILRAKRKQFINSVS VGTINGLLDELLEKRVLNQEEMDTIKLANIT-VMEKARDLCDHVTKKGPRASQMFITYIC NEDCYLAE--------------------ILELQSGPSAET-----VFVTEDSKGG-HPFS SETK-------------EKLNKEGGAFPGP---SG----------SLKFCPLEIAQKLWK ENH-SEIYPIM-KTPTRTRLALIICNTDFQH--------------LSRRVGA-DVDLREM -KLLLQDLGYT-VKVKENLTALEMTKELKEFAACPEHK--TSDSTFLVFMSHGL-Q---- ---E-GICGITYSN--------EVADILKVDTIFQMMNTLKCPSLKDKPKVIIIQ--ACR ----GEKQ-GVVL-LKD-SVGNS--EEGF--------------L-TDAIFE-D-DG-IKK AHIEKDFIAFCSSTP--DNVSWRHPVQGSLFIESLIKHMKEYA-------WSCDLEDIFR KVRFSFEQP----------------DS------RLQMPTTERVTLTKRFYLFPGH----- -------------------------------------------------- >T_rubripes_ENSTRUP00000024467 ------------------------------------------------------------ MDLRLLSQIDAQLDSLEVAALCFLCRDAVSPKSREGITDARGLFKKLHEKRLLENSS--F LSQLLHTIHRKDLLCLLEADSSQPEETDARPL-------LSEYR---------------- -------------------------VMLYKLYEN--LDREDLKKLKFLLSDQLGRRQIEL CKTVLDVFTEMEKKGLLSNTKLDKLHSVLKE-VDQRLAATVHDFM--------------- -----------------------QPLRGILVPRGPGTPPPAVMSMVIPVRLAVPETQ--- ------------------SRGTEQNVSPDAESIFQ--------SSPPA------------ -DD-NEYYALIH---NPRGLCVVFNNETFL-PGA--------N--LPRRGGT-MEDQKRL -RSVFTKFGFT-VQVHNDFTAEAILRELKRLGK-RDFM--NEDALVVCVLSHGL-K---- ---G-CIFGTDGEE-------------VSLQDFTQPFVSSQAPTLAGKPKLFFIQ--ACQ ----GEKL-QKGY-AAW-P-PRPEQEMAKAE------------S-QLEEDA-GPVK-AKV VADSADFLIGMATVE--DYKSFRNTKNGSIYIQELCNQLQKSA---ESP-GHDHILDILT RVNREVSEG--------------EFLN------HKQMPEP-KYTLTKKLVLKYL------ -------------------------------------------------- >M_domestica_ENSMODP00000020556 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LLLWLPQLSPIP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----QGVYDTSG---AKVALVLCV---------------------TRDRPGA-KQDLKAL -KRLFQTLGFK-SILKMNPTAQDFRKELTRFRELLDARRTNVSCALVALMAHGEPQ---- ---G-RLLGADGQM-------------VEVEEMVSELS--ACQVLQGKAKVVLLQ--GCR ----GGNR-DPGM-RPR-ALPWL--------------------G-SWLQHW-L-QR-PST IPSHADILQVYANLQ--GYVAYRN-ENGSDFIQTLVQVIIANP--------DQDLLELLT EVNKRLCEM--------------EVRGPDCDEIRKMSVEI-QSSLRKQLYLK-------- -------------------------------------------------- >G_gallus_ENSGALP00000013591 -----------------------------------------------------------M EFSQLLFVISEALDRTELASLKFLSLEHVTVRKREDIEEPKAFFQALQEKGMIEVGDLFF LKELLYRINRIDLLASYLGSSREEMERELQVPGRAR---VSPFR---------------- -------------------------YLLFQLSEN--ITKDDMKCFKFLLGKELPKCKLSP ETTMPDVFIEMEKKGILKEDNLTVLKTICGK-VDKSLLKKIEDYELNLLGEGEMLVTEGQ RSSTGAPED--------------------------------------------------- ------------------SAIWLASSVAPDSLGNC-----------------------DQ SSQ-LEVYKMTS---RPRGVCLILNNHNF--AKAREAVPELRR--MKDRNGT-HVDADAL -RKVFSNLHFT-VAEYKDCTAEEIRNIVNNYRC-MDHN--NKDCFVCCILSHGK-K---- ---G-IIYGVDGQE-------------VPIQELTTSFTGQNCQSLAGKPKVFFVQ--ACQ ----GDAY-QKGV-TIE-TDSGEQ-------------------D-YSLETD-ARFQ-LDC IPSEADFLLGMATLQ--DYVSYRSPSQGTWYIQSLCQHLESSC-----P-RGEDILTILT AVNQEVSSK----------ID--KQNA------GKQMPQP-SFTLRKKLIFPVN------ -------------------------------------------------- >M_domestica_ENSMODP00000034033 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LT-DKVLKEKRRLFVESVD RGVINGLLDDLLELQVLNLEEMEILKEESRT-IRDKARVLIDAIISKGPKASQCFTKSIW ERDGHLAE--------------------KLGLSSGKRKYL-----LGKADHSIHG-EKLK TKQR-------------HTIGKWKVIHDDA---ID----------TLKLCSYADFQRIKK EKE-GQIYPVMEKG-FRTRLALIICNKEFDE--------------LPRRNGA-ENDVTGM -QNLLEGLGYR-VHVKENLTALEMESALKQFASYPEHR--TSDSTFLVLMSHGV-P---- ---G-GICGKDYRE--------KDPQILDVNKIFQIFNTSNCPNLKDKPKILILQ--ACR ----GEND-GAVL-VND-SSDSS-EHRCI--------------Q-NLPIFE-D-DA-VRR AHVEKDFIAFCSSTP--DNVSWRNIYKGSLFIIQLILYIKKFA-------WCYHLYEIFC KVQHSFENR----------------EE------KLQMPTIERATLTKYFYLFPGN----- -------------------------------------------------- >M_mulatta_ENSMMUP00000012893 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MADSIQEKQRMAGQMLLQTFF NIDQISPS--------------------------------------------KKAHLNME ARPP---------------------ESGES---AD----------ALKLCPHEEFLRLCK ERA-EEIYPIKERN-DRTRLALIICNTEFDH--------------LPPRNGA-DFDITGM -KELLEGLDYS-VDVEENLTAKDMESALRAFAARPEHK--SSDSTFLVLMSHGI-L---- ---E-GICGTAHDE--------KNPDVLLYDTVFQIFNNRNCLSLKDKPKVIIVQ--ACR ----GANR-GELW-VRD-SPASL-EVASS--------------Q-SPENLE-E-DA-VYK THVEKDFIAFCSSTP--HNVSWRDSTMGSVFITQLITCFQKYS-------WCCHLEEVFR KVQQSFETP----------------RA------KAQMPTIERLSMTRYFYLFPGN----- -------------------------------------------------- >H_sapiens_ENSP00000364878 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MADEKPSNGVLVHMVKLLI KTFLDGIFDDLMENNVLNTDEIHLIGKCLKF-VVSNAENLVDDITETAQTAGKIFREHLW NSKKQLS----------------------------------------------------- ------------------------------------------------------------ ----SDISSDGER--EANMPGLNIRNKEFNY--------------LHNRNGS-ELDLLGM -RDLLENLGYS-VVIKENLTAQEMETALRQFAAHPEHQ--SSDSTFLVFMSHSI-L---- ---N-GICGTKHWD--------QEPDVLHDDTIFEIFNNRNCQSLKDKPKVIIMQ--ACR ----GNGA-GIVW-FTTDSGKAGADTHGR--------------L-LQGNIC-N-DA-VTK AHVEKDFIAFKSSTP--HNVSWRHETNGSVFISQIIYYFREYS-------WSHHLEEIFQ KVQHSFETP----------------NI------LTQLPTIERLSMTRYFYLFPGN----- -------------------------------------------------- >M_mulatta_ENSMMUP00000037892 VEGGRRARVVTESKRNFFLGACPTPFPTEHVELGRLGGSETAMVPGKGGADYILLPFEEM DFNRNLYDIGEQLDSEELASLKFLSLDCIPQRKQEPIKDALMLFQRLQEKRMLEENNLSF LKELLFRINRLDLLTTYLNTRKEEMERELQAPGRAQ---ISAYR---------------- -------------------------VMLYQISEE--VGRSELRSFKFLLQEEISKCKLDD DMNLLDIFVEMEKRVILGEGKLDILKRVCAQ-VNKSLLKIINDYEEFSRERTRSLEGSPE EGSN-------------------------------------------------------- ------------------GEELCGLMTISDSPREQ---------------------DSES QTL-DKVYQMKS---KPRGYCLIINNYDF--TKAREKVPKLHS--IRDRNGT-HLDAEAL -TATFEELHFE-IQHHNDCTVEKIYKILKTYQL-MDHS--NKDCFICCILSHGD-K---- ---G-IIYGTDGQE-------------APIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQ ----GDNY-QKGI-PVE-TDSEEQ---------------------PYLEMDLSSPQ-TRY IPDEADFLLGMATVN--NCVSYRNPAEGTWYIQSLCQSLRERC-----P-RGDDILTILT EVNYEVSNK----------DD--KKNM------GKQMPQP-TFTLRKKLVFPSD------ -------------------------------------------------- >P_pygmaeus_ENSPPYP00000014606 -----------------------------------------------------------M DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQ---ISAYRFHFCRMSWAEANSQCQ TQSVPFWWRVDHILIR---------VMLYQISEE--VSRSELRCFKFLLQEEISKCKLDD DMNLLDIFIEMEKRVILGKGKLDILKRVCAQ-INKSLLKIINDYEEFSR----------- ------------------------------------------------------------ ------------------GEELCGVMTISDSPREQ---------------------DSES QTL-DKVYQMKS---KPRGYCLIINNHNF--AKAREKVPKLHS--IRDRNGT-HLDAGAL -TTTFEELHFE-IKPHNDCTVEQIYEILKIYQL-MDHS--NMDCFICCILSHGD-K---- ---G-IIYGTDGQE-------------APIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQ ----GDNY-QKGI-PVE-TDSEGQ---------------------PYLEMDLSSPQ-TRY IPDEADFLLGMATVN--NCVSYRNPAEGTWYIQSLCQSLKERC-----P-RGDDILTILT EVNYEVSNK----------DD--KKNM------GKQMPQP-TFTLRKKLVFPSD------ -------------------------------------------------- >M_musculus_ENSMUSP00000027015 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MA-DKILRAKRKQFINSVS IGTINGLLDELLEKRVLNQEEMDKIKLANIT-AMDKARDLCDHVSKKGPQASQIFITYIC NEDCYLAG--------------------ILELQSAPSAET-----FVATEDSKGG-HPSS SETK-------------EEQNKEDGTFPGL---TG----------TLKFCPLEKAQKLWK ENP-SEIYPIMNTT-TRTRLALIICNTEFQH--------------LSPRVGA-QVDLREM -KLLLEDLGYT-VKVKENLTALEMVKEVKEFAACPEHK--TSDSTFLVFMSHGI-Q---- ---E-GICGTTYSN--------EVSDILKVDTIFQMMNTLKCPSLKDKPKVIIIQ--ACR ----GEKQ-GVVL-LKD-SVRDS--EEDF--------------L-TDAIFE-D-DG-IKK AHIEKDFIAFCSSTP--DNVSWRHPVRGSLFIESLIKHMKEYA-------WSCDLEDIFR KVRFSFEQP----------------EF------RLQMPTADRVTLTKRFYLFPGH----- -------------------------------------------------- >D_rerio_ENSDARP00000034228 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MAKSIKDHLQDALSNIGADN LRRFQSRLGDRKQEPRVRKSTIEKLKDEIDL-----VDLLVNTFTSDAVSVTVDILRGIK CNAVAEEL--------------------LENTGQVYSIFKLCKKNSHYTKPPIIITDVFM FCFLGGVSQPEPPVPEPIPKDPAQLKEL-----------------KVTPCSQQFKNKILR EKG-QETYEIKDKS-VRKRLALLINNVDFDDK-------------AMKRSGS-EKDEENM -EKLLKELDYQ-VVKRPNLSAKEMDEAIRDFAQREEHK--YSDSAFVVIMSHGK-R---- ---D-AIMGVHYHR------TNNPSDSFPVDNVYRRLNSENCPALRDKPKVILIQ--ACR ----GGEH-GRVW-ASD-GEPD-----------------------EPIEIE-D----DDF VHKEKDFISLMSCTP--DTKSYRHVQNGTFYVQTLVDVFIKCA-------HEDHIEELFR KVLRRFEHP-------------NMIGN------FKQMACKDRATLPKLFYLFPGL----- -------------------------------------------------- >H_sapiens_ENSP00000351273 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQ---ISAYR---------------- -------------------------VMLYQISEE--VSRSELRSFKFLLQEEISKCKLDD DMNLLDIFIEMEKRVILGEGKLDILKRVCAQ-INKSLLKIINDYEEFSKERSSSLEGSPD EFSN-------------------------------------------------------- ------------------GEELCGVMTISDSPREQ---------------------DSES QTL-DKVYQMKS---KPRGYCLIINNHNF--AKAREKVPKLHS--IRDRNGT-HLDAGAL -TTTFEELHFE-IKPHDDCTVEQIYEILKIYQL-MDHS--NMDCFICCILSHGD-K---- ---G-IIYGTDGQE-------------APIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQ ----GDNY-QKGI-PVE-TDSEEQ---------------------PYLEMDLSSPQ-TRY IPDEADFLLGMATVN--NCVSYRNPAEGTWYIQSLCQSLRERC-----P-RGDDILTILT EVNYEVSNK----------DD--KKNM------GKQMPQP-TFTLRKKLVFPSD------ -------------------------------------------------- >P_troglodytes_ENSPTRP00000021879 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQ---ISAYR---------------- -------------------------VMLYQISEE--VSRSELRSFKFLLQEEISKCKLDD DMNLLDIFIEMEKRVILGEGKLDILKRVCAQ-INRSLLKIINDYEEFSKERSSSLEGSPD EFSN-------------------------------------------------------- ------------------GEELCGVMTISDSPREQ---------------------DSES QTL-DKVYQMKS---KPRGYCLIINNHNF--AKAREKVPKLHS--IRDRNGT-HLDAGAL -TTTFEELHFE-IKPHDDCTVQQIYEILKIYQL-MDHS--NMDCFICCILSHGD-K---- ---G-IIYGTDGQE-------------APIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQ ----GDNY-QKGI-PVE-TDSEEQ---------------------PYLEMDLSSPQ-TRY IPDEADFLLGMATVN--NCVSYRNPAEGTWYIQSLCQSLRERC-----P-RGDDILTILT EVNYEVSNK----------DD--KKNM------GKQMPQP-TFTLRKKLVFPSD------ -------------------------------------------------- >T_nigroviridis_ENSTNIP00000001216 ------------------------------------------------------------ --------------------------------------SAYQLFLSLCDQDHLSEERPHL LSELLSIIQRTRLL------------RDLDLRSSATSNLISAYR---------------- -------------------------KLLYSLSED--LTDDNLKEIKFLLTETLPRRKLED NVTTLEVFLELECMDLLSKTNLGLLKSILQP-VCPVLAERIRQFEAQNSCQPAADWGFAV KKITDPLQVQGGSDALPSLP---------------------------------------- ------------------EENQSSSRTEASVMSSANAVGIKPGTLMLGLSPPPVGSPNFP VQD-LGTYPMTT---LPRGCCLIISNYDF--QGS--------G--LGMRNGT-RTDEECL -KKVFEWLGFK-VEIHRDCTGKEILSLMQELAD-KSQQ--RWDCLVCCILSHGL-E---- ---G-CVHGVDGDQ-------------VSIKKLIEPFLGTNCPAMAGKPKLFFIQ--ACQ ----GKKQ-QGVV-HLE-SDGAE--------------------H-SDVDTD-AVRL-SNC IPSHADFLLGMATVP--DYVSYRDRERGTWYIQSLCEYLVKMV-----P-RGFDLMSILT KVNEDVSKK----------ND--NTGD------RKQMPQP-VFTITKRIVFPVPSGPAPV LPHFPFVEDSP--------------------------------------- >O_cuniculus_ENSOCUP00000002346 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ERYDMSG---ARLALTLCV---------------------TKAREGS-EADLDAL -ERMFQQLGFE-STVKRDPTAQQFQEELEKFQQTIDAWKDPVSCAFVVLMAHGD-E---- ---G-VLKGEDEEM-------------VKLEDLFEVLNNKNCKALRAKPKVYIVQ--ACR ----GEHR-DLGE-TVG-E------------------------D-QVMMIT-R-DS-PQT IPTYTDTLHVYSTVE--GYIAYRHDQEGSCFIQTLTDVFMNRT---------GPILELLT EXXXXXXXX----------XXXQEGKA------RKVNPEI-QSTLRKRLYLQ-------- -------------------------------------------------- >D_melanogaster_FBpp0082755 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MDDTDFSLFGQKNKHKKDKADATK---------------------------------- ------------------------------------------------------------ ------------------IAHTPTSELDLKRIIIS------------------------R PTN-EDTYE-NC---ARAGIALILNHKDVK------------G--QKQRVGT-ERDRDDM -EATLQGFGFD-VRTFDDLTFSEINDTLKEVAR-EDHS--QNDCFVLAVMSHGT-E---- ---G-KVYAKDM-S-------------YPVERLWNPFLGDNCKTLKNKPKLFFIQ--ACR ----GANL-EKAV-EFS-SFAVMTREL----------------V-PEPAAA-VQPI-TYA IPSTADILVFYSTFD--KFFSFRNVDDGSWFIQSLCRVLDQAAANEAATPEGVELLRLLT AVNRKVAYE---YQSNTK-NE--ALNQ------MKEMPNF-MSTLTKTFQLRVKPKT--- -------------------------------------------------- >X_tropicalis_ENSXETP00000008971 -----------------------------------------------------------M DFNSMLLSIDDGLGREDIEALKFLCRDVLRKNKLLSVRSGQELFQQLMTEDLINEDNFFL LKELLYIINHHSLLRN-LGTNKEKVQKALPRQGR-----ISPYR---------------- -------------------------QMLYQLSEN--IAGDDEKRVYFLLPLQ---KKHKE NKTFLEVLCQLERENSITEDDVELLEDIFKK-VAPDLLKIIEKYKERGDKLHQTENHLID PSAPPEDEHELINPPLSIQVSSKDSELWDKGTESLIEHTGMIHEEAEKEDDKSGNI---- ------------------NHQLSDLRLNSEMTPQA------------------------- -NK-EEFYDMNH---KHRGYCLIIDNSVF--MK------------GNRREGS-DKDAGAL -SDVFSWLGLE-VDIFENLMSEQIRDCLKRFKS-RDHS--ERDCFVCCILTHGE-S---- ---G-TVMGSDDKE-------------VSIREIMSYFTAISCTSLVLKPKLFFIQ--ACQ ----GKFT-HPSS-KVE-A------------------------D-AIVPEE-NKKY-VVN VPKDADFLLGMSTVD--GYAAYRHTREGSWYIQALCKNLVELV-----P-RGEDILAILT KVNKDVSLK----------EG--QQGI------LKQMPQP-SYTLLKKLRFPVPDVPFRP KTCQENSP------------------------------------------ >A_aegypti_AAEL012143-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------M-MDHS--EHDCVSITILSHGE-L---- ---G-YLYAKDC-Q-------------YKLDIIWSYFTANRCPTLAGKPKVFFIQ--ACQ ----GDQL-DAGV-TL--AER------------------------TETDSA-G-SM-SYK IPAHADFLIAYSTIP--GFYSWRNTQKGSWFMQSLCQELTQHG-------KKYDLLTLLT FVAQRVAYD---FESNTPDIP--MMHQ------QKQIPCV-TTMLTRLLRFTEK------ -------------------------------------------------- >R_norvegicus_ENSRNOP00000016613 -----------------------------------------------------------M DFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQESINDVLVLFQRLQEEGMLEEDNLSF LKELLFHISRRDLLSRVLKSSPEEMVRELQVLGKAQ---VSAYR---------------- -------------------------VMLFKLSED--MDKEDLKSFKFLLITEIPKCKLQD NSSLLDIFVEMEKRTILAENNLVTLKSICFR-VNRSLLGRIDDYERSSTERRMSTEGGEE LPVSVL------------------------------------------------------ ------------------DEVTIKMQDMWDSPGEQ---------------------ESES LNS-DNVYQMKS---KPRGYCLIFNNNNF--SKAREDIPKLSN--MRDRKGT-NYDEEAL -SKTFKELHFE-IVSFSDCTASQIHEVLVSYQS-KDHK--GKDCFICCILSHGD-K---- ---G-IVYGTDGKE-------------ASIYELTSYFTGSKCPSLAGKPKIFFIQ--ACQ ----GNNF-QKAV-PVP-DETGLE-------------------QEHVLEED-SSSY-KNY IPDEADFLLGMATVK--NCVSYRDPTRGTWYIQSLCQSLRERC-----P-RGEDILSILT GVNYDVSNK----------DN--PRNM------GKQMPQP-IFTLRKKLFFPPN------ -------------------------------------------------- >O_cuniculus_ENSOCUP00000000956 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MA-DRILKDRRKRFINSVG TGTINGLLDELLEKRVLNQEEMEKVRVENAT-VMDKARALLDCVIRKGPQACQICINHIC EDDCHLAG--------------------LLGLSSGPQSEN-----HFNAQDSLEAFSSFS APQT-------------TQDNQVVFTFSGP---------------SLKLCPLETAQRIWK EKS-EEIYPIKMQSSGRTRLALIICNTEFDS--------------LPRRTGA-DVDIRDM -KMLLIGLGYS-VDVKENLNALDMATELKAFADRPEHW--TSDSTFLVFMSHGT-R---- ---D-GICGKNYSE--------QYSDILNVNTIFEMLNTKNCQSLKDKPKVIIIQ--ACR ----GENQ-GIVW-LKD-SIGDS-GNTSL--------------L-NPDDFE-Y-DA-SRI AHIEKDFIAFCSSTP--DNVSWRHPKQGSLFIMRLIKTMQEYA-------WSCDVEEIFR KVRFSFELP----------------EG------RTQMPTTERV--MRRFYLFP-H----- -------------------------------------------------- >M_mulatta_ENSMMUP00000021744 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------LSAPLEIQGAQP---SG----------RLKLCPHAHFRELKT KRA-DEIYPVMEKE-GRTRLALIICNKEFHY--------------LLNRNGS-ELDLLGM -QDLLENLGYS-VVIEENLTAQEMETALRQFAARPEHQ--SSDSTFLVFMSHGI-L---- ---N-GICGTEHWD--------QEPDVLHDDTIFEIFNNRNCRSLRDKPKVIIMQ--ACR ----GSGA-GIVW-FTTDSGKASAETHGQ--------------L-LQSSIC-N-DA-VTK AHVEKDFIAFKSSTP--HNVSWRHEISGSVFISQIIYYFKEYS-------WSHHLEEIFR KFERSFETP----------------NV------VTQLPTIMLISIFIYFILF-------- -------------------------------------------------- >C_intestinalis_ENSCINP00000028692 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MSE NKEKDIRESWSQENLPEAGHEIKTELDLNLD-FSRSDATDAGGFD--------------- -----------------------------------------------PGSEGTITE---- ------------------IGDTDQNETIKRGFISL--------DELGE------------ -NF-DFCYNMQH---KKRGLFVVFNQMKFD-KHL--------K--LSERTGS-DKDAAAL -LKTAELLGFE-TEEYLDLERKQIRRKLYELSE-MDHG--DHDCFACAILTHGG-K---- ---DNILYSHDD-E-------------MKLKDFTTPFEADKCRSLASKPKLFFVQ--ACR ----GDLL-DRGA-KVI-H-LKQSTG-----------------D-VLDRNP-SKVE-SYT IPVQADFLISQATAP--DYYAWRSSDKGSIFIQTLCSVFERYS----------------- --------------------D--------------------------------------- -------------------------------------------------- >E_caballus_ENSECAP00000006810 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LAGRGPEKEDPVNLMKSIA RNMFEGFLDDL-ENNVLSRDDLRKLGKRVNR-IVNGTENLVEDLSEKTEVAGKIFLKHLL KPKKQMNLKSLADYEDDESEDT------ESPFSSTESACE-----GEDEETEENAGLSQA SVPP--------------MTDPQETQVSQP---KD----------KLKPCSHDHFRKLKT TKA-EEMYPVMEKK-GRTRLALIICNKKFDY--------------LSDRNGS-EVDLVGM -QDLLGNLGYS-VVVEENLTALEMETALRHFAARQEHR--SSDSTFLVFMSHGD-L---- ---D-GICGTKHNE--------EEPDILHDDTIFQIFNNRNCRSLRDKPKIIIIQ--ACR ----GRGD-GSVW-VTD-TGVASAYSSDQ--------------P-FQGYIW-N-DA-VTK THVEKDFIAFKSSTP--HNISWRTDKTGSIFISKLIYNFRKYS-------CCHHLEEIFR KVQRSFEIP----------------SV------VIQMPTIERVSMTRYFYLFPGN----- -------------------------------------------------- >M_musculus_ENSMUSP00000027012 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MA-ENKHPDKPLKVLEQLG KEVLTEYLEKLVQSNVLKLKEEDKQKFNNAE-RSDKRWVFVDAMKKKHSKVGEMLLQTFF SVDPGSHH---------------------------------------------------- -----------------GEANLEMEEPEES---LN----------TLKLCSPEEFTRLCR EKT-QEIYPIKEAN-GRTRKALIICNTEFKH--------------LSLRYGA-NFDIIGM -KGLLEDLGYD-VVVKEELTAEGMESEMKDFAALSEHQ--TSDSTFLVLMSHGT-L---- ---H-GICGTMHSE--------KTPDVLQYDTIYQIFNNCHCPGLRDKPKVIIVQ--ACR ----GGNS-GEMW-IRE-SSKPQ-LCRGV--------------D-LPRNME-A-DA-VKL SHVEKDFIAFYSTTP--HHLSYRDKTGGSYFITRLISCFRKHA-------CSCHLFDIFL KVQQSFEKA----------------SI------HSQMPTIDRATLTRYFYLFPGN----- -------------------------------------------------- >R_norvegicus_ENSRNOP00000029448 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------FTAKRTHERDPIYKIKGLA KDMLDGVFDDLMDKNVLNGDELLKIGEGASL-ILSKAENLVESFFEKTEMAGKIFAGHIA NSDKQLSL-----LQADRNQITGPSFQILVFNSLSESRGK-----VEDEEMEVNVGVAHA SHLM--------------LTVPQGIQSTEV---QD----------SLKLCSRDWFCTMKT ERA-EEIYPVMEKE-GRTRLALIICNKKFDY--------------LFDRDDA-ETDILNM -KELLQNLGYS-VVIKENLTAQEMETELMKFAGRPEHQ--SSDSTFLVFMSHGI-L---- ---E-GICGVKHRN--------KKPDVLHDDTIFTIFNNSNCPSLRNKPKILIMQ--ACR ----GRHT-GTIW-VSTSKGIATADTDEE--------------C-VLSHRW-N-NS-ITK AHVETDFIAFKSSTP--HNISWKVGKSGSLFISKLIDCFKKYC-------WCYHLEEIFR KVQYSFEVP----------------GE------LTQMPTIERVSMTRYFYLFPGN----- -------------------------------------------------- >O_anatinus_ENSOANP00000016591 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------PPAQLLKDRWCLIIESLT HGMISGLLDDLLQMQVINQEEMDTVREEHHR-PAEKTRALLNSVIPKGDLASQIFIDSLC KKNPFVAA--------------------KLGLSAGGQGQSGNTQFVGQSQMIPAVATSCS VPQA--------------LQAPKTLTESHPDGSGE----------ILKLCPSEEREKLQK ENE-GEIYPVLVKA-GRQRQALIICNIKFEE--------------LCERVGA-ELDIKGM -KKLLEDLDYT-VQVERNLSATEMESKLKMFAGRPEHK--FSDSTFLVFMSHGI-L---- ---E-GICGTKYKK--------QEPDVLSYSTIFRVFNNINCPGLKDKPKIIIVQ--ACR ----GENE-GMAW-VSD-SLGPSATSS----------------Q-EPEDLE-N-DA-IHR THVEKDLIAFCSSTP--DHVSWRDPKTGSLFIVQLIKCFQNHA-------WNCDLESLFL KVQRHFETP----------------KQ------KLQMPTRERATLTKRFFLFPGH----- -------------------------------------------------- >G_gorilla_ENSGGOP00000000205 ---------------------------------------------------YILLPFEKM DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQ---ISAYR---------------- -------------------------VMLYQISEE--VSRSELRSFKFLLQEEISKCKLDD DMXLLDIFIEMEKRVILGEGKLDILKRVCAQ-INKSLLKIINDYEEFSKERSSSLEGSPD EFSN-------------------------------------------------------- ------------------GEELCGVMTISDSPREQ---------------------DSES QTL-DKVYQMKS---KPRGYCLIINNHNF--AKAREKVPKLHS--IRDRNGT-HLDAGAL -TTTFEELHFE-IKPHDDCTVEQIYEILKIYQL-MDHS--NMDCFICCILSHGD-K---- ---G-IIYGTDGQE-------------APIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQ ----GDNY-QKGI-PVE-TDSEEQ---------------------PYLEMDLSSPQ-TRY IPDEADFLLGMATVN--NCVSYRNPAEGTWYIQSLCQSLRERC-----P-RGDDILTILT EVNYEVSNK----------DD--KKNM------G-------------------------- -------------------------------------------------- >T_rubripes_ENSTRUP00000035020 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MEDKLTSIRLMFVEKVS TQMINQLLDDIFMDGIVSEMEKESITEESNI-RSDKARRLIDSVRKKGERACKKMISHIQ SRDPELSA--------------------VLGLSCGHPAPPVFNRRAPDGRSRVIFNSPIN RC---------------VLEGETERQRRERALKIS------------------PGNHSLL LQS-FQVYPGTREA-INNRVALVITNITFFHQ-------------CLNRKGA-EKDEENM -ETLLKGLGYE-VVKYRNLTGRAIEDAVIDFSKRPKLK--DTDSVVVVIMSHGR-L---- ---G-VVAGVSTQS------PTFEDDLFSLDKIYRHLGPEHCPALLNKPKIIIIQ--ACR ----GDER-GEII-FND-QHPPENPPV----------------S-DDANIQ-E-DA-IRI EHKEKDFIWLLSCTP--DTVSYRALAKGSFLVQVLVDVFNASA-------ERDDLEELFR KVQHRFEDF--------------PIGN------RRQMPTRDRCTLTKRFYFYPGL----- -------------------------------------------------- >A_aegypti_AAEL003439-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MDTADELDVLGFGNKT----------------------------- ------------------------------------------------------------ ------------------NESSTSNENRPLSRPTC------------------------- ----DEYYDMSN---KRRGIALVFCHMNFA------------V--MAKRNGT-DKDRDDI -CSTLSGLDFD-VRVFNDLRRKELLRTLKNVSR-EDHS--ENDCLVVVVMSHGD-Q---- ---G-VLYASDK-K-------------YYVDSLWEKFTGNACPSLIGKPKLFFVQ--ASR ERQPGKKG-EGGR-EEE-SQASV--------------------DVVDSPND-S-SA-LYF IPTMADFLVMYSTYD--GYYSGKDPLQRSCLIQSLCMELDENG-------RERDLLALLT GVSRRALYT---CESSVPHNE--KDNA------LKPIPCV-VSMLTKTFFFTKKT----- -------------------------------------------------- >A_aegypti_AAEL011562-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MDQRDRHQIQHNMDQLIQ HTNYGVLMAECVGRQMMSEVMKAIIEDRYPD-EASRHKKLFEKITKRGPHAFDILVSICQ RNFPTAYKLLKNGNVSTVGSSSRNSSQFEFNSTYHPNRVRSISAGDYSGSELLRQRLANL SIGSPSYSEEDDAKNNNDTVEETTDKGGKRRLQEF--------GEKVRSLYKVELSARPQ SHRILEAYEMRR---RNRGVVFIVNVITYI-NET-----------HPTRNGA-EADKYNL -VSLFQQLGFT-VFYYEDLTSDEFNNLIKELKQ-SSYL--STECFVFYILAHGNHT---- KGRD-KIYLNDNSV-------------LYVEDVLALFNNANCPKLIRRPKLFFFS--ICR ----GDNP-DYGTLRLA-EHTER--------------------D-GMINLK-K-DP-PTN MPTYADMLICFSTVP--GYAAHRDKQYGSWFVESMCKVWAQHA-------HDTDVEQLMK LVGKDSSTY----------RT--EHHN------ALQTLGSEQRGFFNVLYLNPGYYED-- --------------------------------------------------