>D_melanogaster_FBpp0086432 ---------------------------------------------------MTELGMELE SVRLATFGEWPLNAPVS-AEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRR SSPICSMVLAPNHCGNV-PRSQESDNEGNSVVDSP------------------------- ----------------------------ESCSCPDLLLEANRLVTFKD-------WPNP- --NITPQALAKAGFY---YLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKRFFPQCPRVQM GPLIEFATGKNLDELGIQPT---------------------------------------- -------------------------------------------TLPL---RPKYACVDAR LRTF-T---DWPI-SNIQPASALAQAGLYY-QKIGDQVRCFHCNIGLRSWQKEDEPWFEH AKWSP--KC---QFVLLAKGPAYVSEVLATTAA-NASSQPATAPAPTL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------QADVLMDEAPA---KEALALGIDGGVVRNAIQR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KLLSSGCAFSTLDEL----------------LHDIFDDAGAGAAL-- --EVREPPEPSAPFIEPCQATTSKAASVPIPV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ADSIPAKPQAAEAVANISKITDEIQKMSVATPN GN--LSL--EEENRQLKDARLCKVCLDEEVGVVFLP------------------------ -------------------------------CGHLATCNQCA------------------ ----------------------------------PSVANCPMCR---ADIKG---FVRTF L-S--------------------------------------------------------- - >A_aegypti_AAEL006633-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ELKREEHRLATYVN-------WPIS- --HISPSSLAKAGFY---YTYNADQVKCAWCEGVIGQWELGDDPFVEHQKFFPNCAKVIS NGISSNPILDPTIGIQPV------------------------------------------ -------------------------------------------KTPY---APQFSSLDSR IRSF-E---NWTT-GHIQDPERLAQAGFYY-LGRADEVHCFYCDGGLRFWLADDDPWFEH ARCFP--KC---QFVQLVKGQLFIENVQSQIKS-TSSNQQQQMQASGP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TMSLDEALATEPV---QLALSMGLNAGRIRAVTKR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------QLDSTGHPYADSQAL----------------IEAVLDGQIQDEEL-- --EPSTSSRMDRRIESEVSRLLW------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TAISSTAGPNLSS FSSTFSTPSPSFDSAPTSDGDVIVSSDPLSSPSTSSIAN--------------------- ---------------------------NASTSSAVKCNNVPESLAQMAAAARPTETAEVD KT--LRL--EEENKRLKDARECKICMADEVGVVFCP------------------------ -------------------------------CGHLVSCVQCA------------------ ----------------------------------PAVTNCPVCR---AVIKG---RVRTF L-S--------------------------------------------------------- - >X_tropicalis_ENSXETP00000048002 ---------------------------MANEILDR-RPDLAKRLKSNPSMCKITLEFSCE LYRLSTFSTFPSNTHVS-ERNLAKAGFYYTGQDDKVKCFTCGLMLDNWKKGDNAFEKHKK LYPSCSFIQNVPSV-NLGASLYSAFSPPASNS---------TP----MHA-ASAENDKVE AITLKYSS-IPQDPVTLRGIEDLSHVR-ISEY---MYTEEARLNSFQE-------WSNM- --FLTPAELAKAGFY---FVGPGDKVACFTCDGKLNNWEPNDNAMSEHRRHFPNCPFVKS STRVS----------------------------------------SR------------- -------------------------------------------FSVS---NVSMQASSAR LKTF-A---SWPP-RIPISPTRLAEAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EYLLHIRGQDYVQEVQERYPH-LLDQ--LLSSSENQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------NEAKNIP- -IIRLG-TENSQEDEIMMSTPMV---QTALEIGFNRRLVKRTIQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KMLTSGENYSQLDDL----------------ISDLLI--AQEEQT-- --EEERNRQAEENSL--DDISVIRKSRMALSQHIASRS--IPILDYLLSSNDITAAEYEA IKLKTQPILQAQEMIETIITKGKTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VQTLKNCLQKHDPNLFRQLFTEQSLKCISLDDY SD--LSM--EEQLRRLQEERTCKICMDQEVSIVFIP------------------------ -------------------------------CGHLVVCKDCA------------------ ----------------------------------PSLRKCPICR---GTIKG---TVRTF L-S--------------------------------------------------------- - >M_musculus_ENSMUSP00000013949 -----------------------------MNMVQD-SAFLAKLMKSAD-TFELKYDFSCE LYRLSTYSAFPRGVPVS-ERSLARAGFYYTGANDKVKCFCCGLMLDNWKQGDSPMEKHRK LYPSCNFVQTLNPANSLEASPRPSLPSTAMST---------------MPL-SFASSENTG YFSGSYSS-FPSDPVNFRANQDCPALS-TSPYHFAMNTEKARLLTYET-------WPLS- --FLSPAKLAKAGFY---YIGPGDRVACFACDGKLSNWERKDDAMSEHQRHFPSCPFLKD LGQSA----------------------------------------SR------------- -------------------------------------------YTVS---NLSMQTHAAR IRTF-S---NWPS-SALVHSQELASAGFYY-TGHSDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EYLLRIKGQEFVSQVQAGYPH-LLEQ--LLSTSDSP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EDENADAA- -IVHFGPGES-SEDVVMMSTPVV---KAALEMGFSRSLVRQTVQW--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------QILATGENYRTVSDL----------------VIGLLD--AEDEMR-- --EEQMEQAAEEEES--DDLALIRKNKMVLFQHLTC-V--TPMLYCLLSARAITEQECNA VKQKPHT-LQASTLIDTVLAKGNTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ATSFRNSLREIDPALYRDIFVQQDIRSLPTDDI AA--LPM--EEQLRKLQEERMCKVCMDREVSIVFIP------------------------ -------------------------------CGHLVVCKDCA------------------ ----------------------------------PSLRKCPICR---GTIKG---TVRTF L-S--------------------------------------------------------- - >T_guttata_ENSTGUP00000013125 -----------------------------LNTVED-SPFLTSIMRQSALCDELKYDLSCE LYRMSTFSTFPMNTPVS-ERSLARAGFYYTGVQDKVKCFSCGLTLDNWQPGDNAMEKHKQ LYPRCSFVQRMLSDNNVGLSSRSAFSPSIANS---------LPPSLHSIA-LSPSLEQVG YFSGSFSS-FPQDPVTTRAAEDLSFLS-PKLHNNSMRTEDARLCTFQS-------WPLT- --FLSPTDLAKAGFY---YLGTADKVACFTCGGQLYNWEPKDNAVSEHRRHYPNCPFVEN LIRDQ----------------------------------------QS------------- -------------------------------------------FNVS---NVSMQTHEAR VKTF-L---NWPT-RIPVQPEQLADAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWIEH AKWFP--RC---EYLLRVKGREFVDQIQARFPH-LLEQ--LLSTSDPP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------VNENLDPP- -IIHFEPGESHSEDAIMMNTPVV---KAALEMGFSRRLIKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILVTGENYKTVNDL----------------VSDLLM--AEDETI-- --QEEKEKQLEEVAS--DDLYLIQKNRMALFQRLTC-V--LPILGSLLSAKVITELEHDV IKQKTQIPLQARELIDTVLVKGNEA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ASIFRNCLRDCDPVLYKDLFVEKTIKYVPTEDV SG--LPM--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCKECA------------------ ----------------------------------PSLRKCPICR---GIIKG---TVRTF L-S--------------------------------------------------------- - >G_gallus_ENSGALP00000035646 -----------------------------MNIMDS-SPLLASVMKQNAHCGELKYDLSCE LYRMSTFSTFPVNVPVS-ERRLARAGFYYTGVQDKVKCFSCGLVLDNWQPGDNAMEKHKQ VYPSCSFVQNMLSLNNLGLSTHSAFSPLVASN---------LSPSLRSMT-LSPSFEQVG YFSGSFSS-FPQDPVTTRAAEDLSHLR-SKLHNPSMSTEEARLRTFHA-------WPLM- --FLSPAELAKAGLY---YLGTADKVACFTCGGQLSNWEPKDNAMSEHRRHFPNCPFVEN LMRDQ----------------------------------------PS------------- -------------------------------------------FNVS---NVTMQTHEAR VKTF-I---NWPT-RIPVQPEQLADAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWIEH AKWFP--RC---EYLLRVKGGEFVSQVQARFPH-LLEQ--LLSTSDTP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------VDENMD-P- -IIHFEPGESPSEDAIMMNTPVV---KAALEMGFSRRLIKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILATEENYKTVNDL----------------VSDLLT--AEDEKR-- --EEEKERQFEEVAS--DDLSLIRKNRMALFQRLTS-V--LPILGSLLSAKVITELEHDV IKQKTQTPLQARELIDTVLVKGNAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ASIFRNCLKDCDPVLYKDLFVEKSMKYVPTEDV SG--LPM--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCKECA------------------ ----------------------------------PSLRKCPICR---GTIKG---TVRTF L-S--------------------------------------------------------- - >R_norvegicus_ENSRNOP00000014560 -------------------------------IMEN-STVLSNWTKENK--EKMKYDFSCE LYRMSTYSAFPRGVPVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPTEKHRQ FYPSCSFVQTLLS-GGLQSAAKNT-SPAKSRF---------------AHS---LPLEQ-- --GGIHSS-LPSNPLNSRAVEDFS-LR-MNPCSYAMSTEEARFLSYSM-------WPLS- --FLSPAELAKAGFY---YTGPGDRVACFACGGKLSNWEPNDDPLSEHRRHFPHCPFLEN TS-ET----------------------------------------QR------------- -------------------------------------------FSVS---NLSMQTHSAR MRTF-L---YWPS-SVLVQPEQLASAGFYY-VDHNDDVKCFCCDGGLRCWEPGDDPWIEH AKWFP--RC---EFLIRMKGQEFVDEIQARYPH-LLEQ--LLSTSDTS------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EEENADPPE RVVHLGPGEN-WEDAVMMNTPVV---KAALDMGFSRSLVRQTVQR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------QILATGENYRTVSDI----------------VSALLN--AEDERR-- --EEEKERQSEETAS--GDLSLIRKNRMALFQQLTC-V--IPILDDLLEASVLTKEEHDI IRQKTQIPLQARELIDTILVKGNAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ASVFKNSLKEVDSTLYEHLFVEKTMKYIPTEDV SG--LSL--EEQLRRLQEERTCKVCMDREVSIVFIP------------------------ -------------------------------CGHLVVCRECA------------------ ----------------------------------PSLRKCPICR---GTIKG---TVRTF L-S--------------------------------------------------------- - >R_norvegicus_ENSRNOP00000007702 -----------------------------MNMVQG-SAFLAKLMKSAD-TFELKYDFSCE LYRLSTYSTFPAGVPVS-ERSLARAGFYYTGVNDKVKCFSCGLMLDNWKQGDSPIEKHRK LYPSCSFVQTLNPANSLEASPQPPLPSTATST---------------MPS-GFAASESTG YFSGSYSS-FPSDPVNFRANQDCPAFS-TSPYHFAMNTEKARLLTYQT-------WPLS- --FLSPAELAKAGFY---YTGPGDRVACFACGGKLSNWDRKDDPLSEHRRHFPSCPFLKD VGQFT----------------------------------------SQ------------- -------------------------------------------YTVS---NLSMQTHAAR VRTF-S---TWPS-SALVHPQELASAGFYY-TGHSDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EYLIRIKGQEFVGQVQAGYPH-LLEQ--LLSTSDSP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EDETGEAA- -IVHLGPGEN-WEDAVMMNTPVV---KAALDMGFSRSLVRQTVQR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------QILATGENYRTVSDL----------------VIGLLD--AEDEMR-- --EEQTEQEAEEEES--DDLTLIRKNKMVLLQHLTP-V--TPILDCLLSARVITEQEYDA VKQKPHT-LQARTLIDTVLAKGNTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ATSFRNSLQEIDPGLYRDIFVRQNIRSLPTDDI AA--LPM--EEQLRKLQEERTCKVCMDREVSLVFIP------------------------ -------------------------------CGHLVVCKECA------------------ ----------------------------------PSLRKCPICR---GTIKG---TVRTF L-S--------------------------------------------------------- - >A_carolinensis_ENSACAP00000012475 -----------------------------LIIMNTFDTFAAKLKNVPD-VGQLKYDLSCE LFRMSTFSTFPLHVPVS-ERSLARAGFYYTGVKDKVKCYSCGLMLDNWKKGDNPLDKHKQ LYPSCSVVQNLTSLNNLGSSFYSAFSPPSLSV---------GHSSSHSPQ-QTPNLDQVG YFSGSFSS-VPQEL--PKLTEGISHVR-PKVANSAMSSEEARLLTFKT-------WPLT- --FLSPSSLAKAGFY---YIGPADKVACFVCGGHLGNWEPKDNAMSEHRRHFPTCPFVE- QTQSQ----------------------------------------PG------------- -------------------------------------------FTVS---NLSMQTYRAR VGTF-E---NWPM-TVPVLPQRLADAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWEEH AKWFP--RC---EYLIHRKGQEFVRCVQARFPH-LLEQ--LLSTSDIP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------VDENTSPP- -IIRFEPGENGSEDEVIMKTPVV---EAALEMGFRRRLVKQIVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILRTGESYKSINDL----------------VSDLIA--ADDEKR-- --DDEKEPQMEESTS---DLSLIRKNRVALFQRLTC-V--LPILECLLASKAISSLEYQV IKQKTQTPLQARELIDTILVKGNKA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ANIFRNCIQESDPVLYQDLFVEKNMTYIPA-DV SG--LSM--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCKECA------------------ ----------------------------------PSLRKCPICR---GTIKG---TVRTF L-S--------------------------------------------------------- - >M_musculus_ENSMUSP00000091422 -----------MDKTVSQRLGQGTLHQKLKRIMEK-STILSNWTKESE--EKMKFDFSCE LYRMSTYSAFPRGVPVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPVEKHRQ FYPSCSFVQTLLS-ASLQSPSKNM-SPVKSRF---------------AHS---SPLER-- --GGIHSN-LCSSPLNSRAVEDFS-SR-MDPCSYAMSTEEARFLTYSM-------WPLS- --FLSPAELARAGFY---YIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPHCPFLEN TS-ET----------------------------------------QR------------- -------------------------------------------FSIS---NLSMQTHSAR LRTF-L---YWPP-SVPVQPEQLASAGFYY-VDRNDDVKCFCCDGGLRCWEPGDDPWIEH AKWFP--RC---EFLIRMKGQEFVDEIQARYPH-LLEQ--LLSTSDTP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GEENADPTE TVVHFGPGES-SEDVVMMSTPVV---KAALEMGFSRSLVRQTVQR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------QILATGENYRTVNDI----------------VSVLLN--AEDERR-- --EEEKERQTEEMAS--GDLSLIRKNRMALFQQLTH-V--LPILDNLLEASVITKQEHDI IRQKTQIPLQARELIDTVLVKGNAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ANIFKNSLKEIDSTLYENLFVEKNMKYIPTEDV SG--LSL--EEQLRRLQEERTCKVCMDREVSIVFIP------------------------ -------------------------------CGHLVVCQECA------------------ ----------------------------------PSLRKCPICR---GTIKG---TVRTF L-S--------------------------------------------------------- - >C_familiaris_ENSCAFP00000022277 -----------MHKTTSQRLVPG-SYQRIKRTMED-STILRNQTIGNK--QKIKYDFSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKPGDNPVEKHKQ LYPSCSFIHSLVSLTSRDSTSKNI-SAMRNSF---------------THS-ISPTLEH-G SFSGSHSN-LAANPVSSRAGEDFSPLS-TNPYSYAMSTEEARFLTYHM-------WPLT- --FLSPSDLARAGFY---YIGPGDKVACFACGGTLSNWEPKDDAMSEHRRHFPNCPFLEN SL-ET----------------------------------------LR------------- -------------------------------------------FSIS---NLSMQTHAAR LRTF-V---YWPS-SVPVRPEQLASAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EFLIRMKGQEFVDEIQARYPH-LLEQ--LLSTSDTP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GDENADPPN SFVHFGPGENHSEDTVMMNTPVV---KAALEMGFSRILVRQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILSTGENYRTVNEI----------------VLALLN--AEDETR-- --EEEKERQTEEMAS--DDLSLIRRNRMALFQQLTC-V--LPILDNLLKANVINKQEHDI IKQKTQIPLQARELIDTVLVKGNSA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ANIFKSCLKEIDSTLYKNLFVDKNMKYIPTEDV SG--LSL--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCQECA------------------ ----------------------------------PSLRKCPICR---GIIKG---TVRTF L-S--------------------------------------------------------- - >E_caballus_ENSECAP00000010270 -----------------------------MNIVEN-SVFLSNLMKSAN-MFELKYDFSCE LYRISTYSTFPPGVPVS-ERSLARAGFYYTGINDRVKCFCCGLMLDNWKQGDNPTEKHKK LYPSCSFVQNLNSVNISGATSQLAFSSSVTNS---------------THS-LLPSLENSG YFSGSYSS-FPSNPVNSGPNHDFSALR-TSPYHCAMNTEKARLLTFQM-------WPLT- --FLSPTDLAKAGFY---YIGPGDRVACFACGGKLSNWEPKDDAMSEHLRHFPNCPFVEN QFEDT----------------------------------------SR------------- -------------------------------------------YTVS---NLSMQTHAAR FRTF-C---NWPS-SVQVPPEQLASAGFYY-MGHSDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EYLIRIKGQEFISRVQANYPH-LLEQ--LLSTSDNP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EDENAESP- -IIHFGPGENHSEDAVMMNTPVV---KAALEMGFSRRLIKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTTGENYKTISDL----------------VLELLN--AEDEMR-- --EEEKERATEEKES--GDLSLIRKNRMALFRHLTC-V--LPILDSLLTARVINEQEYDV IKQKTQTSLQSRELIDTILVKGNFA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ATIFKNSLQEIEPTLYKHLFVQQDIKYIPTEDV SD--LPM--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCKDCA------------------ ----------------------------------PSLRKCPICR---GTIKG---TVRTF L-S--------------------------------------------------------- - >H_sapiens_ENSP00000227758 -----------MHKTASQRLFPGPSYQNIKSIMED-STILSDWTNSNK--QKMKYDFSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQ LYPSCSFIQNLVS-ASLGSTSKNT-SPMRNSF---------------AHS-LSPTLEHSS LFSGSYSS-LSPNPLNSRAVEDISSSR-TNPYSYAMSTEEARFLTYHM-------WPLT- --FLSPSELARAGFY---YIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLEN SL-ET----------------------------------------LR------------- -------------------------------------------FSIS---NLSMQTHAAR MRTF-M---YWPS-SVPVQPEQLASAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EFLIRMKGQEFVDEIQGRYPH-LLEQ--LLSTSDTT------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GEENADPP- -IIHFGPGESSSEDAVMMNTPVV---KSALEMGFNRDLVKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTTGENYKTVNDI----------------VSALLN--AEDEKR-- --EEEKEKQAEEMAS--DDLSLIRKNRMALFQQLTC-V--LPILDNLLKANVINKQEHDI IKQKTQIPLQARELIDTILVKGNAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDV SG--LSL--EEQLRRLQEERTCKVCMDKEVSVVFIP------------------------ -------------------------------CGHLVVCQECA------------------ ----------------------------------PSLRKCPICR---GIIKG---TVRTF L-S--------------------------------------------------------- - >M_mulatta_ENSMMUP00000004536 -----------MHKTASQRLFPGPSYQNIKSIMED-STILSDWTNSNK--QKMKYDFSCE LYRMSTYSTFPTGVPVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIEKHKQ LYPSCSFIQNLVS-ATLGSTSKNT-SPMRNSF---------------AHS-LSPTLEHSS LFSGSYSS-LSPNPLNSRAVEDLSPSR-TNPYSYAMSTEEARFLTYHM-------WPLT- --FLSPSELARAGFY---YIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLEN SL-ET----------------------------------------LR------------- -------------------------------------------FSIS---NLSMQTHAAR MRTF-M---YWPS-SVPVQPEQLASAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EFLIRMKGQEFVDEIQGRYPH-LLEQ--LLSTSDTT------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GDENADPP- -IIHFGPGESSSEDAVMMNTPVV---KSALEMGFSRDLVKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTTGENYKTVNDI----------------VSALLN--AEDEKR-- --EEEKERQAEEMAS--DDLSLIRKNRMALFQQLTC-V--LPILDNLLKANVINKQEHDI IKQKTQIPLQARELIDTVLVKGNAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDV SG--LSL--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCQECA------------------ ----------------------------------PSLRKCPICR---GIIKG---TVRTF L-S--------------------------------------------------------- - >P_pygmaeus_ENSPPYP00000004357 -----------MHKTASQRLFPGPSYQN-KSIMED-STILSDWTNSNK--QKMKYDFSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQ LYPSCSFIQNLVS-ASLGSTSKNT-SPMRNSF---------------AHS-LSPTLEHSS LFSGSYSS-LSPNPLNSRAVEDFSSSR-TNPYSYAMSTEEARFLTYHM-------WPLT- --FLSPSELARAGFY---YIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLEN SL-ET----------------------------------------LR------------- -------------------------------------------FSIS---NLSMQTHAAR MRTF-M---YWPS-SVPVQPEQLASAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EFLIRMKGQEFVDEIQGRYPH-LLEQ--LLSTSDTT------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GEENADPP- -IIHFGPGESSSEDAVMMNTPVV---KSALEMGFNRDLVKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTTGENYKTVNDI----------------VSALLN--AEDEKR-- --EEEKEKQAEEMAS--DDLSLIRKNRMALFQQLTC-V--LPILDNLLKANVINKQEHDI IKQKTQIPLQARELIDTILVKGNAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDV SG--LSL--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCQECA------------------ ----------------------------------PSLRKCPICR---GIIKG---TVRTF L-S--------------------------------------------------------- - >P_troglodytes_ENSPTRP00000007251 -----------MHKTASQRLFPGPSYQNIKSIMED-STILSDWTNSNK--QKMKYDFSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQ LYPSCSFIQNLVS-ASLGSTSKNT-SPMRNSF---------------AHS-LSPTLEHSS LFSGSYSS-LSPNPLNSRAVEDISSSR-TNPYSYAMSTEEARFLTYHM-------WPLT- --FLSPSELARAGFY---YIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLEN SL-ET----------------------------------------LR------------- -------------------------------------------FSIS---NLSMQTHAAR MRTF-M---YWPS-SVPVQPEQLASAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EFLIRMKGQEFVDEIQGRYPH-LLEQ--LLSTSDTT------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GEENADPP- -IIHFGPGESSSEDAVMMNTPVV---KSALEMGFNRDLVKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTTGENYKTVNDI----------------VSALLN--AEDEKR-- --EEEKEKQAEEMAS--DDLSLIRKNRMALFQQLTC-V--LPILDNLLKANVINKQEHDI IKQKTQIPLQARELIDTILVKGNSA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDV SG--LSL--EEQLRRLQEERTCKVCMDKEVSVVFIP------------------------ -------------------------------CGHLVVCQECA------------------ ----------------------------------PSLRKCPICR---GIIKG---TVRTF L-S--------------------------------------------------------- - >D_rerio_ENSDARP00000065554 -IYMRTHTQGMTIKPFSLLAIPFPISLSQMEILQN-SAFLRGLCRTSG-PADLQYDNSSE LFRISTYAKFPTTAAVT-ERSLARAGFYYTGLGDRVQCFRCNVTADNWQSGDCPAERHKQ LSPNCSFIQSLPATANLLSSSHSAFSPLRNVAVLQLSAPATAAPSTTAPSTSGQTEEQVG YLNMGFTNLAPSSPISSRGVEDMSHQRPPACHNPGMRREQERLDTFQN-------WTLA- --TVTPAELAKAGLY---YLGQGDRVACFSCGGQLGSWEPGDRAVSEHQRHYPNCRFVRG DRADNIPLSGG----------------------------------GL------------- -------------------------------------------SNVS---NSAMQQCEER LLTF-V---NWPS-RIPVRPDQLAKAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP-SRC---EYLLQEKGQEFVHQIQARFPR-LFEQ--LLTNGDSN------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SREFVDPP- -VVHLGPGEDRSEDAVMMNNPVV---KSALEMGFERGLVKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTSGENYKTVQEL----------------VSDLLS--AEDEKR-- --EEERELLAEEMAS--DGFTFLKKHHAALSQRLKS-V--QSLMDHLLEENVISQKEYDS IRNCTSVKQQTGQLIDLVLSKGNAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AEVFRNWIKKNDVYLLRELMAQTNEAASPSQDL SD--LPM--EEQLRRLQEERTCKVCMDKEVNIVFIP------------------------ -------------------------------CGHLVVCKECA------------------ ----------------------------------PSLRKCPICR---GMVKG---TVRTF L-S--------------------------------------------------------- - >M_mulatta_ENSMMUP00000004533 -----------------------------MNIVEN-SIFLSNLMKSAN-TFELKYDLSCE LYRMSTYSAFPAGVPVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPVEKHKK LYPSCRFVQSLNSVNNSEATSQPAFPSSVTNS---------------THS-LLPGTENSG YFSGSYSS-FPSNPVNSRANQDFSALM-RSSYHCAMNNEKARLLTFQT-------WPLT- --FLSPTDLAKAGFY---YVGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIEN QLQDT----------------------------------------SR------------- -------------------------------------------YTVS---NLSMQTHAAR FKTF-F---NWPS-SVLVNPEQLASAGFYY-VGNSDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EYLIRIKGQEFIRQVQASYPH-LLEQ--LLSTSDSP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EDENAESS- -IIRFEPGEDHSEDAIMMNTPVV---NAAVEMGFSRSLVKYTVQR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILATGENYRLISDL----------------VLDLLN--AEDEMR-- --EEERERATEEKES--NDLLLIRKNRMALFQHLTC-V--IPILDSLLTARIINEQEHDV IKQKTQTSLQARELIDTILVKGNIA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ATVFRNSLQEADAVLYERLFVQQDIKYIPTEDV SD--LPV--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCKDCA------------------ ----------------------------------PSLRKCPICR---STIKG---TVRTF L-S--------------------------------------------------------- - >E_caballus_ENSECAP00000000598 --------------------------------MED-STILSSWTVGNK--QKMKYDFSCE LYRMSTYSTFPTGVPVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDNPIEKHKQ LYPSCSFIQNLVSVTSLESTSKNTSSPMRNSF---------------THS-LSPTLEHSG SFSGSYSN-LSPNLVNSRAVEDFSPLR-TNPYSYAMSTEEARFLTYHM-------WPLT- --FLSPSELARAGFY---YIGPGDRVACFACGGTLSNWEPKDDAMSEHRRHFPNCPFLEN SL-ET----------------------------------------LR------------- -------------------------------------------FSIS---NLSMQTHAAR LRTF-M---YWPP-RVPVQPEQLASAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EFLISMKGQEFVDEIQARYPH-LLEQ--LLSTSDTP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GDENADPP- -IVHFGPGESSSEDAVMMNTPVI---KAALEMGFSRSLVKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTTGENYKTVNDI----------------VSALLN--AEDEKR-- --EEEKERQTEEMAS--DDLSLIRRNRMALFQQLTC-V--LPILDNLLKANVINKQEHDI IKQKTQIPLQARELIDTVLVKGNAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ANIFKNCLKEIDSTLYENLFVEKNMKYIPTEDV SG--LSL--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCQECA------------------ ----------------------------------PALRKCPICR---GIIKG---TVRTF L-S--------------------------------------------------------- - >H_sapiens_ENSP00000376897 -----------------------------MNIVEN-SIFLSNLMKSAN-TFELKYDLSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKK LYPSCRFVQSLNSVNNLEATSQPTFPSSVTNS---------------THS-LLPGTENSG YFRGSYSN-SPSNPVNSRANQDFSALM-RSSYHCAMNNENARLLTFQT-------WPLT- --FLSPTDLAKAGFY---YIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIEN QLQDT----------------------------------------SR------------- -------------------------------------------YTVS---NLSMQTHAAR FKTF-F---NWPS-SVLVNPEQLASAGFYY-VGNSDDVKCFCCDGGLRCWESGDDPWVQH AKWFP--RC---EYLIRIKGQEFIRQVQASYPH-LLEQ--LLSTSDSP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GDENAESS- -IIHFEPGEDHSEDAIMMNTPVI---NAAVEMGFSRSLVKQTVQR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILATGENYRLVNDL----------------VLDLLN--AEDEIR-- --EEERERATEEKES--NDLLLIRKNRMALFQHLTC-V--IPILDSLLTAGIINEQEHDV IKQKTQTSLQARELIDTILVKGNIA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDV SD--LPV--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCKDCA------------------ ----------------------------------PSLRKCPICR---STIKG---TVRTF L-S--------------------------------------------------------- - >P_troglodytes_ENSPTRP00000007250 -----------------------------MNIVEN-SIFLSNLMKSAN-TFELKYDLSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPIEKHKK LYPSCRFVQSLNSVNNLEATSQPTFPSSVTNS---------------THS-LLPGTENSG YFGGSYSN-SPSNPVNSRANQDFSALM-RSSYHCAMNNENARLLTFQT-------WPLT- --FLSPTDLAKAGFY---YIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIEN QLQDT----------------------------------------SR------------- -------------------------------------------YTVS---NLSMQTHAAR FKTF-F---NWPS-SVLVNPEQLASAGFYY-VGNSDDVKCFCCDGGLRCWESGDDPWVQH AKWFP--RC---EYLIRIKGQEFIRQVQASYPH-LLEQ--LLSTSDSP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RDENTESS- -IIHFEPGEDHSEDAIMMNTPVV---NAAVEMGFSRSLVKQTVQR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILATGENYRLVNDL----------------VLDLLN--AEDEIR-- --EEERERATEEKES--NDLLLIRKNRMALFQHLTC-V--IPILDSLLTAGIINEQEHDV IKQKTQTSLQARELIDTILVKGNIA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ATVFRNSLQEADAVLYEHLFVQQDIKYIPTEDV SD--LPV--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCKDCA------------------ ----------------------------------PSLRKCPICR---STIKG---TVRTF L-S--------------------------------------------------------- - >O_anatinus_ENSOANP00000016616 ------VHKTTSRGETRPVSPATPTEYFVMNVVAN-SMFLSNLMNGNS-GYELKYDFSCE LFRMSTYSTFPTNVPVS-ERSLARAGFYYTGASDKVKCFSCGLMLDNWKPGDSAIEKHKQ LYPSCSFIQNLLQTHNPGASSYSAFCPPPLGS------------LSPTAT-ISPSLEPSG YFSGSFSS-FPLDPVTSRAIEDLSQPR-PHVDNSAMSSEEARICTFQS-------WPLT- --FLSPSALAKAGFY---YTGPGDRVACFTCGGKLSNWEPKDDAMSEHRRHFPGCPFLER QTRDA----------------------------------------SR------------- -------------------------------------------FNVS---NASMQTHAAR VKTF-L---NWPA-RIPVQPEQLASAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWIEH AKWFP--RC---EYMIRMKGQEFVNQIQARYPH-LLEQ--LLSTSDTP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------VDESADPP- -IIHFGPGENPAEDAIMMSNPVV---KAALEMGFSRRLVKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTTGENYKTVNDL----------------VSDLLN--AEDETR-- --EEEKERQNEEMAS--DDLSLIRKNRMALFQHLTC-V--LPILDSLLSAGVISEQERDV IKQKTQTSLQARELIDTVLVKGNAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ANIFKNCLKEDDCILYKNLFVEKNMKYIPTEDV SG--LPM--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCKECA------------------ ----------------------------------PSLRKCPICR---GTIKG---TVRTF L-S--------------------------------------------------------- - >G_aculeatus_ENSGACP00000027283 ---------------------------------KN-NPFLMGLCRNGP-PPDLQYDNSSE LFRISTFARFP-ASGVT-ERSLARAGWFYIGVGDRVQCFRCNVTAEGWQAGDCPTEKHRQ LSPTCSFIQSLPSTTNLLSSSHSAFSPLRIAPAV--------------PA-VSQGEEPVG YLNMGFSAPPPSSPLSSRGVEDMSHQR-PTCHNPSKRKEQDRLDSFHP-------WTLS- --IITPSELAKAGFY---YLGQGDRVACFSCGGQLSNWEPGDRAVSEHQRHYPNCRFLSS ------------------------------------------GAAAL------------- -------------------------------------------NNVS---NPAMQQSDER LLTF-V---NWPA-RIPVRPDQLAKAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EYLIQEKGQEFVHQIQARFPR-LFEQ--LLANGDNN------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SREFIDPP- -VVHLGPGEERSEDAVMMNTPVI---KSALEMGFERGLVKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTSGENYRTVQEL----------------VLDLLS--AEDQKR-- --EEEREMVAEAMAS--DGFTFVKRHQATLIQRLKS-V--EPVLEHLREQNVLSPDEYGG LKAQTSAQLQNGKLIELVLTKGNAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AEVFRNWIQKNDVHLLRDLMAQSNEAASPSQDL SD--LPM--EEQLRRLQEERTCKVCMDKEVNIVFIP------------------------ -------------------------------CGHLVVCKECA------------------ ----------------------------------PSLRKCPICR---GLVKG---TVRTF L-S--------------------------------------------------------- - >P_pygmaeus_ENSPPYP00000004355 -----------------------------MNIVEN-SIFLSNLMKSAN-TFELKYDLSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPIEKHKK LYPSCRFVQSLNSVNNLEATSQPTFPSSVTNS---------------THS-LLPGTENSG YFSGSYSS-FPSNPVNSRVNQDFSALM-RSSYHCAMNNENARLLTFQT-------WPLT- --FLSPTDLAKAGFY---YIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIEN QLQDT----------------------------------------SR------------- -------------------------------------------YTVS---NLSMQTHAAR FKTF-F---NWPS-SVLVNPEQLASAGFYY-VGNSDDVKCFCCDGGLRCWESGDDPWVQH AKWFP--RC---EYLIRIKGQEFIRQVQASYPH-LLEQ--LLSTSDSP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GDENAESS- -IIRFEPGEDHSEDAIMMNTPVV---NAAVEMGFSRSLVKQTVQR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILATGENYRLVNDL----------------VLDLLN--AEDEIR-- --EEERERATEEKES--NDLLLIRKNRMALFQHLTC-V--IPILDSLLTARIINEQEHDV IKQKTQTSLQARELIDTILVKGNIA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ATVFRNSLQEADAVLYEHLFVQQDIKYIPTEDV SD--LPV--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCKDCA------------------ ----------------------------------PSLRKCPICR---STIKG---TVRTF L-S--------------------------------------------------------- - >B_taurus_ENSBTAP00000053449 ----------------------------------MTFNSFEGSKTCVPADIDKDEEFVEE FNRLKTFANFPSSSPVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAIGRHRR VSPNCRFINGFYFENNA-AQPTYSGVQNGQY-KAE--------------N-YLGNRNHF- VLERPSET-HAHYLLRTGQVVDLSDT--VYPRNPVMCSEEARLKSFHN-------WPDYA --HLTPRELARAGLY---YTGIDDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLG RNI-N-----------------------------------------MQSESSVVS----- --SDRNFPNST--------------------------------NAPI---NPAMADYEAR IITF-G---TW---MYSVNKEQLARAGFYA-LGEGDKVQCFHCGGGLNDWKPSEDPWEQH AKWFP--GC---KYLLEEKGEEYVNNIHLTHSI-EESLVSHILNTPSP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------IFISDDTIFQNPMV---QEAIRMGFSFKDIKKTMEG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KIQTSGSNYKSLEVL----------------VADLVN--AQKDNT-- --QD-ESSQTSL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q KD--IST--EEQLRLLQEEKLCKICMDRNIAVVFIP------------------------ -------------------------------CGHLVTCKQCA------------------ ----------------------------------EAVDKCPMCY---TAITL---RQKIF M-S--------------------------------------------------------- - >T_rubripes_ENSTRUP00000043752 ---LLSPDPPLGGPTFTLILLCFHTKMETLVQLKN-NPFLMGLCRNCP-PPDLQYDNSSE LYRISTFARFP-TSGVT-ERSLARAGWFYTGVGDRVQCFKCNVTAEGWQAGDCPTEKHRQ LSPSCSFIQSLPSTSNLLSSSHSAFSPLRIAPAIPLSG---AGPAVPNPS-ANQGEEPVG YLNMGFSAPPPSSPLISRGVEDMSHQR-PTCHNPNMRREQDRLESFHS-------WTLT- --IITPAELAKAGFY---YLSQGDRVACFSCGGQLSNWEPGDRAMSEHQRHYPNCRFVRG DRADNISLAGAAPG-------------------------------GL------------- -------------------------------------------TNVS---NPAMQQSEER LLTF-V---NWPS-RIPVRPDQLAKAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EYLLQERGQDFVHQIQARFPR-LFEQ--LLTNGDTT------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SREFVDPP- -VVHLGPGEERSEDAVMMNTPVI---KSALEMGFERSLVKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTSGENYRTVQEL----------------VSDLLS--AEDQKR-- --EEEKEMLAEAMASALDGFTFVKRHQAALIQRLKS-V--EPVLEHLREQNVLSHEEYSG LKAQTSAQQQTARLIELVLTKGNAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AEVFRNWIQKNDVHLLRDLMAQSSEASSPSQDL SD--LPM--EEQLRRLQEERTCKVCMDKEVNIVFIP------------------------ -------------------------------CGHLVVCKECA------------------ ----------------------------------PSLRKCPICR---GLVKG---TVRTF L-S--------------------------------------------------------- - >C_familiaris_ENSCAFP00000022282 -----------------------------MNIVQN-SIFLSNLLRSSP-VFELKYDHSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTGAKDRVRCFCCGLMLDNWKAGDSPTGKHRN LYPSCSFIQNLSAVSTVGAASQPPAPLSEARS---------------THA-QSPGLERSS YFSASYSS-FPVDPVDFRPSPAMSPWR-AGPSCVTMKSEEDRLCTFQG-------WPLA- --FPLPSALARAGFY---YVGPGDRVACFACGGKLSNWEPDDDALSEHLRHFPDCPFVEG QLQAT----------------------------------------VR------------- -------------------------------------------YTAS---NLSMQTLAAR SRTF-C---NWPP-RAPVHPEQLASAGFYY-MGHSDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EYLIRIKGQEFISQIQASYPH-LLEQ--LLSTSDNT------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EDENTESP- -IVHFGPGEYHSEDAVMMNTPVV---MAALEMGFSRSLVRQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILSTGENYRTVNEI----------------VSDLLH--VEDEIR-- --EEEKERAAENRES--DDVSLIRKNKMVLFQHLTY-V--LPILDSLLMAGVLNEQEHSS IKQKARTSLQARELIDTVLVKGSSA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VTIFKNSLQEIDPMLYKRFFVQQDRKYIPTEDI SD--LPV--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCRDCA------------------ ----------------------------------PSLRKCPICR---GTVRG---TVRTF L-S--------------------------------------------------------- - >P_troglodytes_ENSPTRP00000038304 ----------------------------------MTFNSFEGSKTCVPADINKEEEFVEE FNRLKTFANFPSGSPVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK VSPNCRFINGFYLENSA-TQSTNSGIQNGQY-KVE--------------N-YLGSRNHF- ALDRPSET-HADYLLRTGQVVDISDT--IYPRNPAMYSEEARLKSFQN-------WPDYA --HLTPRELASAGLY---YTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLG RNL-N-----------------------------------------IRSESDAVS----- --SDRNFPNST--------------------------------NLPR---NPSMADYEAR IFTF-G---TW---IYSVNKEQLARAGFYA-LGEGDKVKCFHCGGGLTDWKPSEDPWEQH AKWYP--GC---KYLLEQKGQEYISNIHLTHSL-EECLVRTTEKTPSL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TRRIDDTIFQNPMV---QEAIRMGFSFKDIKKIMEE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KIQISGSNYKRLEVL----------------VADLVN--AQIKGM-- --QD-ESSQTS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----IST--EEQLRRLQEEKLCKICMDRNIAIVFVP------------------------ -------------------------------CGHLVTCKQCA------------------ ----------------------------------EAVDKCPMCY---TVITF---KQKIF M-S--------------------------------------------------------- - >C_familiaris_ENSCAFP00000034255 ----------------------------------MTFNSFEGAKTCVPAGINKDEEFVEE FNRLKTFANFPSSSPVS-ASTLARAGFLYTGEGDTVRCFSCHASIDRWQYGDSAVGRHRK VSPNCRFINGFYFENTA-AQPTNPGIQNGQY-NAE--------------N-YLRNRDHF- VLDRPSET-HADYLLRTGQVVDISDT--TYPENPAMYSEEARLNSFQN-------WPDYV --HLTPRELASAGFY---YTGIDDQVQCFCCGGKLKNWEPCDNAWSEHRRHFPNCFFVLG RNV-N-----------------------------------------IRSESDVAS----- --TDRNVPNST--------------------------------SIPE---NPAMADYEAR IVTF-R---MW---MCSINKEQLARAGFYS-LGDGDKVKCFHCGGGLTDWKPSEDPWEQH AKWFP--GC---KYLLEEKGQEYINNIHLTHSVVSHILLRTAERTRSL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TERIEDAIFQNPML---QEAIRMGFSFKDIKKIMEE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KIQTSGSNYVSLEAL----------------VSDLVS--AQKDHT-- --QD-ESSQTSL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q KE--ISA--EEQLRLLQEEKLCKICMDRNIAVVFIP------------------------ -------------------------------CGHLVTCKQCA------------------ ----------------------------------EAVDKCPMCY---TVITF---KQKIF M-S--------------------------------------------------------- - >M_domestica_ENSMODP00000000728 ------THKTTSQRKT---CPLLFPKYSIMSVVED-GVLLSHLMSSDT--HEMKYDLSCE LYRMSTYSAFPVNVPIS-ERSLARAGFYYTGVNDRVKCFCCGLMLDNWKQGDNAIDKHKQ LYPSCAFIQNLISVN--LGSSQSTFSSSVNNA---------------TRS-LSLSSEQSG YFSGSYSS-FPLEPVTSRGVEDLSPLN-TSPYSYSMSTEEARILTYQA-------WPLT- --FLSPLDLARAGFY---YIGPGDMVACFACGGKLSNWEPKDDAMSEHRRHFPHCPFLES QIQET----------------------------------------SR------------- -------------------------------------------FNVS---NLSMQTHAAR VKTF-V---TWPP-QIPVHPEQLANAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--R----QYLIRMKGQEFVDQVQARYPH-LLEQ--LLSTSDIP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GDENAELP- -IIHFGPGENNSEDTVMMNTPVI---KAALEMGFSRSLVKQIVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTTGENYKTVNEV----------------VSDLLN--AEDEKR-- --KEEKERQTEEMAS--DDLTLIRKNRMALFQHLTC-V--LPILDSLLTSGVINEQEHDV IKQKTQTSLQARELIDTILVKGNAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ASVFKNCLREIGSVLYNNLFVEKNMKYIPTEDV SG--LPM--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCKECA------------------ ----------------------------------PSLRKCPICR---GIIKG---TVRTF L-S--------------------------------------------------------- - >H_sapiens_ENSP00000360242 ----------------------------------MTFNSFEGSKTCVPADINKEEEFVEE FNRLKTFANFPSGSPVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK VSPNCRFINGFYLENSA-TQSTNSGIQNGQY-KVE--------------N-YLGSRDHF- ALDRPSET-HADYLLRTGQVVDISDT--IYPRNPAMYSEEARLKSFQN-------WPDYA --HLTPRELASAGLY---YTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLG RNL-N-----------------------------------------IRSESDAVS----- --SDRNFPNST--------------------------------NLPR---NPSMADYEAR IFTF-G---TW---IYSVNKEQLARAGFYA-LGEGDKVKCFHCGGGLTDWKPSEDPWEQH AKWYP--GC---KYLLEQKGQEYINNIHLTHSL-EECLVRTTEKTPSL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TRRIDDTIFQNPMV---QEAIRMGFSFKDIKKIMEE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KIQISGSNYKSLEVL----------------VADLVN--AQKDSM-- --QD-ESSQTSL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q KE--IST--EEQLRRLQEEKLCKICMDRNIAIVFVP------------------------ -------------------------------CGHLVTCKQCA------------------ ----------------------------------EAVDKCPMCY---TVITF---KQKIF M-S--------------------------------------------------------- - >P_pygmaeus_ENSPPYP00000023167 ----------------------------------MTFNSFEGSKTCVPADINKEEEFVEE FNRLKTFANFPSGSPVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK VSPNCRFINGFYLENSA-TQSTNSGIQNGQY-KVE--------------N-YLGSRNHF- ALDRPSET-HADYLLRTGQVVDISDT--IYPRNPAMYSEEARLKSFQN-------WPDYA --HLTPRELASAGLY---YTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLG RNL-N-----------------------------------------IRSESDAVS----- --SDRNFPNST--------------------------------NLPR---NPSMADYEAR IFTF-G---TW---IYSVNKEQLARAGFYA-LGEGDKVKCFHCGGGLTDWKPTEDPWEQH AKWYP--GC---KYLLEQKGQEYINNIHLTHSL-EECLVRTTEKTPSL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TRRIDDTIFQNPMV---QEAIRMGFSFKDIKKIMEE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KIQISGSNYKSLEVL----------------IADLVN--AQKDST-- --QD-ESSQTSL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q KE--IST--EEQLRRLQEEKLCKICMDRNIAIVFVP------------------------ -------------------------------CGHLVTCKQCA------------------ ----------------------------------EAVDKCPMCY---TVITF---KQKIF M-S--------------------------------------------------------- - >M_musculus_ENSMUSP00000110746 ----------------------------------MTFNSFEGTRTFVLADTNKDEEFVEE FNRLKTFANFPSSSPVS-ASTLARAGFLYTGEGDTVQCFSCHAAIDRWQYGDSAVGRHRR ISPNCRFINGFYFENGA-AQSTNPGIQNGQY-KSE--------------N-CVGNRNPF- APDRPPET-HADYLLRTGQVVDISDT--IYPRNPAMCSEEARLKSFQN-------WPDYA --HLTPRELASAGLY---YTGADDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLG RNV-N-----------------------------------------VRSESG-VS----- --SDRNFPNST--------------------------------NSPR---NPAMAEYEAR IVTF-G---TW---TSSVNKEQLARAGFYA-LGEGDKVKCFHCGGGLTDWKPSEDPWEQH AKWYP--GC---KYLLDEKGQEYINNIHLTHSL-EESLGRTAEKTPSL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TKKIDDTIFQNPMV---QEAIRMGFSFKDIKKTMEE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KIQTSGSSYLSLEVL----------------IADLVS--AQKDNT-- --ED-ESSQTSL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q KD--IST--EEQLRRLQEEKLCKICMDRNIAIVFVP------------------------ -------------------------------CGHLVTCKQCA------------------ ----------------------------------EAVDKCPMCY---TVITF---KQKIF M-S--------------------------------------------------------- - >E_caballus_ENSECAP00000017630 ----------------------------------MTFNSFEGSKTCVPADIDKDEEFVEE FNRLKTFANFPSSSPVS-ASTLARAGFLYTGEGDTVQCFSCHAAVDRWQYGDSAVGRHRK VSPNCRFINGFYFENNA-AQPTNPGVQNGQY-KVE--------------N-YLGNRNHF- VLGRPSET-HAEYLLRTGQVVDISDT--IYPRNPAMCSEEARLKSFQN-------WPDYA --HLTPGELASAGLY---YTGIDDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLG RNV-N-----------------------------------------IRSESDVVS----- --SDRNFSNST--------------------------------NLPR---NPAMADYEAR IITF-G---TW---IYSVNKEQLARAGFYA-LGEGDKVQCFHCGGGLTDWKPSEDPWEQH AKWYP--GC---KYLLEEKGQEYISNIHLTCSL-EESLVRTAEKT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TERIDDTIFRNPMV---QEAIRMGFSFRDIKKIMEE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KIHTSGSNYRSLEIL----------------VADLVN--AQKDNT-- --QD-ESSQTSL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q QE--ISA--EEQLRLLQEEKLCKICMDRNIAVVFIP------------------------ -------------------------------CGHLVTCKQCA------------------ ----------------------------------EAVDKCPMCN---TVITF---KQKIF M-S--------------------------------------------------------- - >O_latipes_ENSORLP00000006992 -----------------------------LVQLKN-SKFLMGLCRNGP-PSDLQYDNSSE LFRFSTFARFP-TSVVT-ERSLARAGWFYTGVGDRVQCFRCNVTAEGWLAGDCPTEKHRQ LSPTCPFIQSLPSTTNLLSSSHSAFSPLRIAQAMPVSSERRQGPAASNPS-GGQSEEAVG YLNMAFSAPPPSSPLASRGVEDLSHQR-PTCHNPSMRREQDRLDSFQP-------WAIS- --IITPAELAKAGFY---YLGQNDRVACFSCGGQLSNWEPGDRAVSEHQRHYPNCRFVRG DRADNVPLVAGA-TALSAAAS--------------------SGALAL------------- -------------------------------------------TSVS---NPSMQQSEDR RLTF-V---NWPS-RIPVRPEQLAKAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EYLLQEKGQDFVHQIQARFPR-LFEQ--LLTNGENS------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SREFVDPP- -VVHLGPGEDRSEDAVMMNTPVI---KSALEMGFERSLVKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTSGENYRTVQEL----------------VSDLLS--AEDQKR-- --EEEREMLAEAMAS--DGFTFVKRHQAALIQRLKS-V--EPVLEHLREQNVLSAEEYGS LLAQTSAQQQTARLIELVLNKGNAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AEVFRNWIQKNDVHLLRDLMAQSNEASSPSQDL SD--LPM--EEQLRRLQEERTCKVCMDKEVNIVFIP------------------------ -------------------------------CGHLVVCKECA------------------ ----------------------------------PSLRKCPICR---GLVKG---TVRTF L-S--------------------------------------------------------- - >T_nigroviridis_ENSTNIP00000012883 ---L----PALFEGLLPFILLCFDTKMETLVQLKN-NPFLMGLCRNCP-PPDLQYDNSSE LYRISTFARFP-SSGVT-ERSLARAGWFYTGVGDRVQCFKCNVTAEGWQAGDCPTEKHRQ LSPSCTFIQSLPSTSNLLSSSHSAFSPLRIAPAIPLSG---AGPAVPNPS-ANPGEEPVG YLNMGFSAPPPSSPLGSRGVEDMSHQR-PTCHNPNMRREQDRLDSFHS-------WTLT- --IITPAELAKAGFY---YLSQGDRVACFSCGGQLNNWEPGDRAMSEHQRHYPNCRFVRG DRADNISLAGAVPGGLTSQLS--------------------GGVPTL------------- -------------------------------------------SNVS---NPAMQQSEER LLTF-V---NWPS-RIPVRPDQLARAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EYLLQEKGQDFVHQIQARFPR-LFEQQKLLTNGDTS------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SREFVDPP- -VVHLGPGEERSEDAVMMNTPVI---KSALEMGFERSLVKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTSGENYRTVQEL----------------VSDLLS--AEDQKR-- --EEEREMLAEAMAS--DGFTFVKRHQAALIQRLKS-V--EPVLEHLREQNVLSHEEYSG LKAQTSAQQQTARLIELILTKGNAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AEVFRNWIQKNDVHLLRDLMAQSSEASSPSQDL SD--LPM--EEQLRRLQEERTCKVCMDKEVNIVFIP------------------------ -------------------------------CGHLVVCKECA------------------ ----------------------------------PSLRKCPICR---GLVKG---TVRTF L-S--------------------------------------------------------- - >R_norvegicus_ENSRNOP00000009358 ----------------------------------MTFNSFEGSRTVVPADTNKDEEFVEE FNRLKTFANFPSSSPVS-ASTLARAGFLYTGEGDTVQCFSCHAAVDRWQYGDSAVGRHRR ISPNCRFINGFYFENGA-TQSTSPGIQNGQY-KSE--------------N-CVGNRNHF- ALDRPSET-HADYLLRTGQVVDISDT--IYPRNPAMCSEEARLKTFQN-------WPDYA --HLSPRELASAGLY---YTGIDDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLG RNV-N-----------------------------------------VRSESG-VS----- --SDRNFPNST--------------------------------NSPR---NPAMAEYDAR IVTF-G---TW---LYSVNKEQLARAGFYA-LGEGDKVKCFHCGGGLTDWKPSEDPWEQH AKWYP--GC---KYLLDEKGQEYINNIHLTHSL-GESVVRTAEKTPSV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TKKIDDTIFQNPMV---QEAIRMGFNFKDIKKTMEE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KLQTSGSNYLSLEVL----------------IADLVS--AQKDNS-- --QD-ESSQTSL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q KD--IST--EEQLRRLQEEKLCKICMDRNIAIVFVP------------------------ -------------------------------CGHLVTCKQCA------------------ ----------------------------------EAVDKCPMCC---TVITF---KQFLC L-NPAPQ----------------------------------------------------- - >M_domestica_ENSMODP00000018715 ----------------------------------MTFKSFEDSKTCVPPDINKDEDFVEE FNRLKTFANFPSSSPIS-ASTLARAGFLYTGEGDTVKCFSCHAAVDRWQYGDSAVGRHRK VSPNCRFINGFYFEKNA-TRFPNPIIQNCQY-RVE--------------N-CSRNRNHF- ALERPSET-HGEYLLRTGQVIDMSDT--IYPRNPSMCSEEARLRSFQN-------WPDYA --HLTPQELASAGLY---YMGFEDQVQCFCCGGKLKNWEPCDRAMSEHKRHFPKCFFVLG RDVGN-----------------------------------------TRIETD-VS----- --CDRSCPNPT--------------------------------HLPR---NPAMADYEAR LITF-A---TW---IYSVNKEQLAKAGFYA-LGDHDKVLCFHCGGGLTDWKPNEDPWEQH AKWYP--GC---KYLLEEKGQEYVSSIHLVHPF-NSSMVKSRKMASSV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TQEIDDSVLQNPLV---QDAIRMGFNFLEIKKIMRE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KIQSSGNNYTSLELL----------------VADLVS--AQKESS-- --QDGESSPTLS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E KE--IST--EEQLRRLQEEKLCKICMDENIAVVFIP------------------------ -------------------------------CGHLVSCQLCA------------------ ----------------------------------EAIDKCPMCY---TVITF---KQKIF IRKPSPN----------------------------------------------------- - >B_taurus_ENSBTAP00000034604 -----------------------------MNIVEN-SVFLSNLMKSAN-MFELKYDFSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTGVKDKVKCFCCGLMLDNWKQGDNPIEKHKK LYPSCSFVQNLNSINVSGASSQPTFHYSLTNS---------------THS-LLPSLENSG YFSGSYSS-FPSNLLNSGPNQDFSALR-ISSYPCAMNTEKARLLTFQM-------WPLT- --FLSPTDLAKAGFY---YIGPGDRVACFACGGTLSNWEPKDDAMSEHLRHFPNCPFLGN QLQGT----------------------------------------SR------------- -------------------------------------------YTAS---NLSMQTYAAR IKTF-C---SWPS-SVPVHPEQLASAGFYY-VGHSDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EYLIQIKGQEFISRVQASYPH-LLEQ--LLSTSDNP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EDENTESP- -RIERNANQNHYEDMVQLSHPYM---TTGKTIGLTRRTFVGTVIC--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------HILTTGLNYLTICQL----------------LFKLPN--PDRSFV-- --QQEVNKDTSENEK--DDLSLIRKNRMALFQHLTC-V--LPILDSLLTARVISEQEHDV IKQKTQTSLQARELIDTILVKGNFA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ATIFKNSLQEIDPMLYKRLFVQQDIKYIPTENV SD--LPM--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCKDCA------------------ ----------------------------------PSLRKCPICR---GTIKG---TVRTF L-S--------------------------------------------------------- - >O_cuniculus_ENSOCUP00000008505 ----------------------------------MTFNSFEGSKTCVPADINKDEEFVEE FNRLKTFANFPSSSPVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK VSPNCRFINGFYFENSA-AQSTNPGVQNGQY-KGE--------------N-YLGNRNHF- ALDRPSET-HADYLLRTGQVVDISDT--IYPRNPAMCSEEARLKSFQN-------WPDYA --HLTPRELASAGLY---YTGIDDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLG RNV-N-----------------------------------------IRSESDVVS----- --SDRNFPNST--------------------------------NPPR---NPAMADYEAR IISF-G---TW---IYSVNKEQLARAGFYA-LGEGDKVKCFHCGGGLTDWKPNEDPWEQH AKWYP--GC---KYLLEEKGQEYINNIHLTHSL-EESLARTAENTPSQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TKRIDDTIFQSPMV---QEAIRMGFSFREIKKIMEE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KVQMCGSNYKSLEVL----------------VADLVN--AQKSST-- --QD-ESSQTSL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q KE--VST--EEQLRRLQEEKLCKICMDRNIAVVFIP------------------------ -------------------------------CGHLVTCKQCA------------------ ----------------------------------EAVDKCPMCY---TVITF---KQKIF M-S--------------------------------------------------------- - >G_gallus_ENSGALP00000038337 ----------------------------------MTCNGPDSSESGATPATDGDQEWTQE HYRLGTFVEFPHDCPVS-ASALARAGFVYTGEGDKVKCFSCHVTVEGWEPGDSAIDRHKN LSPDCRFITGSAFLENN-VHPLVQSHQHRTE------------------N-GSSNLALPS ALEDLSDV-EADYLLRTRQVVDMSDT--LYPKNPAMCSEEARLKSFHN-------WPPYG --LLTPKELASAGLY---YTGVGDQVACFCCGGKLKNWEPGDRAWSEHKRHFPKCFFVLG RDVGN-----------------------------------------VSTDSICAE----- --LGRSCLNNE--------------------------------QHPR---NPSMAEYERR IQTF-L---AW---IYPVNKEHLAEAGFYS-TGNGDHVVCFHCGGGLQEWKENEDPWDQH AKWFP--GC---KFLRDEKGLEFINNVHLRDGC-RDSTIEAAEVTILP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KDDLLQNQLV---QNAIHMGFSLSEIRSIMEK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KLHLSGESYTSVEDL----------------VADLIS--AQKENI-- --KGEPPKESPL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E QD--LSI--EEKLRRLQEEKLCKICMAKDISVVLIP------------------------ -------------------------------CGHLVACKECA------------------ ----------------------------------EAVNKCPLCC---TNIIK---RQKIF M-Y--------------------------------------------------------- - >T_guttata_ENSTGUP00000003825 ------------------------------------------------ADTDGAREWAQE RERQGTFVGFPQGCPVS-VLALAQAGFVYTGEGDKVKCFSCNTTIEGWVPGDSALERHKK LAPTCKFITESAFLKSD-MDPVAQNYQNRTE------------------N-GTSNSALP- CALDDPDV-EADYLLRTRQVVDMSDS--LYPKNPAMCSEETRLKSFHN-------WPLND --RLTPQELANAGFY---YTGVGDQVACFCCGGKLKNWEPSDRAWSEHKRHFPKCLFVQG RDIGN-----------------------------------------VSSESIPSE----- --LGISGLNNA--------------------------------QHPR---NPSMTKYGKR LQTF-L---SW---IYPVAKERLAEAGFYS-VGNGDHVVCFHCGGGLQEWKENEDPWDQH AKWFP--GC---RFVSNEKGIEFINNVHLKDGC-RDSTVSVLLINHFV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------EIAKINIVLYENPWV---QSAIAMGFSLSEIRNTMEK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RLQMTGESHTSVEDL----------------VADLS---AHTENT-- --REEEPNEIPVE----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------QD EL--IHT--EEKLRRLQEEKLCKICMAKDVSVVFIP------------------------ -------------------------------CGHLVACKECA------------------ ----------------------------------QLLNECPLCR---SDIMK---IQEIF M-Y--------------------------------------------------------- - >X_tropicalis_ENSXETP00000029187 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------VPPNMRSEAERQRSFRA-------WPHTC -RTVSPAELARSGFY---YLGPGDRVQCFSCGGVLRSWEPGDRPDTEHRKFFPSCPFLQV RRGPP--------GGTDSVDG--------------------QILGQLSGEEPDRT----- -------------------------------------------WEPV---CPQMAGEGDR LGSF-S---TWPR-YANGDPQQLAGAGFFY-TGHRDHVKCFHCDGGLRNWEQGDDPWTEH AKWFP--MC---DFLLQVKGEAFIRSVQESFFS-SPETSPESVGSYEG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---SPVSSPGSPPVCPFLSTSVA---QGALQVGFKRNRVSSLMIN--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RFILTGSCYGSVSEL----------------VTDLIR--AEEIHG-- --TESVSVPRAPTQR--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ERPEPPKEPA PP--LST--EEQLRQLKEERMCKVCMDNDVSMVFVP------------------------ -------------------------------CGHLVVCTECA------------------ ----------------------------------PNLRHCPICR---AAIRG---SVRAF M-S--------------------------------------------------------- - >C_intestinalis_ENSCINP00000005161 -------------------------------------------------------DSAME SYRLSTFMKYPQDTPVN-PRHLATAGLYFTGYKDRVKCFCCGLATEQWQFGDD-EKSPRW HRSNCEFIQGHDCGNIP-IGLHCVVKYKLLMELTI--PIFLGSWGWIRPD-NTARENFM- NVTYLNLG-EKNFFQRIELATISSVYHEQVLRSLDLKKEGERMKSFEN-------WPTQN -RTVNPSDLARSGFF---YLGNLDRVQCFSCGGVLRNWNYGDNITAEHRRHFPHCRMTQG TESNN------------------------------------------------------- --RELEMMFPC--------------------------------QHPV---NSHMRHLDSR IVTFDS---RWPKNKTQATIQQIAKAGFFY-LGERDRVKCWYCNGGLQNWDPDDEPWTEH AKWFP--TC---EFLIRSKGPDFVHHMVSLYPN-LPRP--ILQTAQGA------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------NGSQSSGTSSAPIIIDPQKR KLREKLN--------LEMDRDIV---KCVNDMGFELKHIRLCVKR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KLEKENIGFSSAQQL----------------IDEILKLNLDEEEE-- --EELDLETDPKEPAAMETEGGK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LYHEVKP SNFKRYLDQRCTINIRLKLDLTTIVMHRFINQRFIPYVN--------------------- ---------------------------TVRLETTNRSKNDLYYFKYLKQNWLTNGACMVD LT--MSM--QDRLLELQNERKCKICVDKLSDIVFVP------------------------ -------------------------------CGHLCVCQACK------------------ ----------------------------------SKVARCPICK---SKVEK---SIRTY M-S--------------------------------------------------------- - >O_cuniculus_ENSOCUP00000011948 ------------HKTTSPRVVPG-TVYRTQNMMED-STILXXXXXXXX--XXXXXXXXXX XXXXXXXXXSPNGVPVS-ERSLARAGFYYTRVNDKVKCFCCGLMLDNWKQGDNPIEKHKQ LYPSCSFIQNLVS-ASLDSTIKNT-SPVRSSF---------------AHS-LSPTVEPGG SFSGSYSS-LSANPLNSRTVEDFSPLR-TNPYSYSMSSEEARFLTYHM-------WPLS- --FLSPSELARAGFY---YIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPKCPFLEN SL-ET----------------------------------------LR------------- -------------------------------------------FSIS---NLSMQTHASR MRTF-M---YWPS-SAPVGPEQLASAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--XX---XXXXXXXXXXXXXXXXXXXXX-XXXX--LLSTSDPP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GEENADPP- -IVHFGPGESSSEDAVMMNTPVV---KAALEMGFSKSLVKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTTGENYKTVNDI----------------VSALLN--AEDEKR-- --EEEKERQAEEVAS--DDLSLIRKNRMALFQQLTC-V--LPILDHLLKANVINKQEHDI IKQKTQIPLQARELIDTVLVKGNVA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ANIFKNCLKEIDSTLYENLFVEKNMKYIPTEDA SG--LSL--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCQGCA------------------ ----------------------------------PSLRKCPICR---GIIKG---TVRTF L-S--------------------------------------------------------- - >X_tropicalis_ENSXETP00000035327 ---------------------------LAEFVLKEEMTCQCPKMSDGAYDMDVDQNYFEE EVRLASFANFPSSYPVS-APALARAGFYYTGDGDRVKCFSCLAMVEGWQHGDTAIGKHRK ISPNCKFINGFNNLRSDCILTQVPVMQNGFQNSAEDL----------------------- AERSSSEI-MADYLLRTGRVVDMSTP--KYPRHMEMCSEEARLQTFQN-------WPAYS --PLTPKELANAGLF---YTGINDQVKCFCCGGKLMNWEPSDKAWTEHKKHFPECYFVLG RDVGN-----------------------------------------VATEANTHG----- --GRRRG------------------------------------SELA---CPAMNDYNAR LETF-S---SW---SFPIDKETLAKAGFYS-IGDGDATKCFHCGGVLNCWSATDDPWEEH AKAYP--GC---KFLIDEKGQHFINHAQLKRPI-LHKANSADASPALP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KDSNLLKSPLV---TNAQQMGFPLEEIKKVMGQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KLKTTGKNYTCVEEF----------------VSDLC---AQKETV-- --LEKP------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------KE IE--ISL--EEKLRQLEEEKICKVCMDRRISIVFIP------------------------ -------------------------------CGHLVACAVCA------------------ ----------------------------------DVLDKCPICC---TIVER---RQKIF M-S--------------------------------------------------------- - >C_intestinalis_ENSCINP00000000045 ----------------------------------------------------------ME SYRLSTFMKYPQDTPVN-PRHLAAAGFHYTGYKDRVKCFCCGLCVESWCVGDD-VKSPRW HRSNCEFILGQDCGNQP-IGSQNISVQQTARPVPA---------GMIMKS-GPSEFRFT- FVILTFLT-LYSTRPKVELATIASPYHEQLVRSLDLRKESDRFKTYEN-------WPAQN -RTVYASDLARSGFF---YLGNLDRVQCFSCGGVLRNWNYGDNITAEHRRHFPHCRFVRK KTVYQTANVLRG------------------------------------------------ -------------------------------------------GFFTNQFIPYMRNEESR FETFDH---RWPASNVRASPRQIAKAGFFF-LGDRDRVKCWYCNGGLQNWDPDDEPWTEH AKWFP--TH--REVVGKYKGPDFVHRMVSLYPN-LPRP--ILRGPFDV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------PPRVPGANQRAPSPPPPIIDHKVA KQQEQVN--------KFMLGDLV---KSATEMGFETSVIRRVVTR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RLTSGGNLYTSVADL----------------VDDITA--NENEPN-- --SDDDDETNASQPSQTTTVKTPG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DYDVINV TIVLRYILDRPIIHCKQEQTKWRPVKQKQQLE---------------------------- ---------------------------ELFDRHFIKFFRNKVGIKSLKIITNIVWWWLRY VT--PSM--EARIRELQEERKCKICLDKVADIVFVP------------------------ -------------------------------CGHLCTCTECA------------------ ----------------------------------EALRKCPICR---SKIRERDQNLHIY VGW--------------------------------------------------------- - >C_intestinalis_ENSCINP00000009820 -------------------------------------------------------DAAME SYRLSTFMKYPQDTPVN-PRHLAAAGFHYTGYKDRVKCFCCGLCVENWVSGDE-IKSKKW HRNNCELVNGNGSGNQP-IAGDDFKSTISPLCECK------------ALS-MVLKTPKI- QGCRKFSM-PLSFFVRIELATIASPYHEQLVRSLDLRKESDRSKTYEN-------WPAQN -RTVYASDLARSGFF---YLGNLDRVQCFSCGGVLRNWNYGDNITAEHTRHFPHCSLFYA Q----------------------------------------------------------- --LELSEMFPC--------------------------------QYPV---NPHMRNQDMR LATFDQ---RWQQRALQAKPAQISKAGFFF-LGDRDRVKCWYCNGGLQNWDPNDEPWTEH AKWFP--TC---EFLIRSKGPDFVHAMVSKYPN-LPRP--ILRGPFDV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------PPSI--RRNSESTAPPPIMDHKMA EMKTKVK--------KHMESEEA---KSVLEMGFGRKELEKVIKK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KLKKDGKMFKSVVSI----------------IDAM------NDGT-- --DSSDDEMEADEPQTQTPMSIS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------DLGRKGLFPCIGCILKIVIRFKNHIN--------------------- ---------------------------TKYKTNYHKVHTPQIKIKYYP----------TD LS--PSM--LARVAELEEERKCKVCLDKMADIVFIP------------------------ -------------------------------CGHLCTCIECA------------------ ----------------------------------SALNKCPICR---KRIEK---SIRTY L-N--------------------------------------------------------- - >T_rubripes_ENSTRUP00000011958 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------MLEEPRMRREGDRIRTFQE-------WPADA --AVAPADLARAGFF---FLGPGDAVQCFCCGGILRCWMQGDTPGDEHRRHFPTCCFVLG KAVGNIPLQ---AGFSDSVDG--------------------QLLSQLQRMTMDDQGTV-- -------------------------------------------GQAV---YPEMEAEDSR LTTF-H---NWPT-EASVQPDVLARAGFFY-TGHGDNVKCYYCDGGLRNWEPGDDPWQEH AKWFP--RC---EFLIQTRGQEYISNIQDTHFH-LGDTVGGSQSSSSR------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------DIGPRN ASHLPDMV-------RAMLSPVV---QTVLQMGFEAGLVESLVQT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KYLLTGRQYTSVSDL----------------VSDVLQ--AEQEDR-- --ARAPQSTVPSRSR--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ASAHFSPPPTV NE--PSP--EELLRQLQEERTCKVCMDKLVSIVFIP------------------------ -------------------------------CGHLVVCSDCA------------------ ----------------------------------ASLRHCPICR---AVIRG---SVRAF M-S--------------------------------------------------------- - >G_aculeatus_ENSGACP00000003419 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MTDDRGTAPRAPEAPRMRGEGERLRTFGR-------WPADA --PVTSGELAGAGFF---YLGPGDEVQCFCCGGVLKCWARGDRPAAEHRRHFPDCGFALG RPAGNVPLP---AGSSDSVDG--------------------QLLSQLQRMTMDEQGTP-- -------------------------------------------GQAV---HPQLEAEDTR VTTF-H---NWPA-EASVQPDVLARAGFFY-TGHGDNVKCFHCDGGLRNWEPGDDPWQEH AKWFP--RC---EFLIQERGQDYISNVQDSHFH-LDDTVSGSQSSAGR------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------D AGSRNDVVGGLAASSA-MLSPVV---QTVLQMGFEAALVESLVRT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RFLLTGQHYTSVSNL----------------VSDVLQ--AEQEDQ-- --RGSRSAGNTERSE--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FPRTA TD--PSP--EELLRQLQEERTCKVCMDKLVSIVFIP------------------------ -------------------------------CGHLVVCADCA------------------ ----------------------------------ASLRHCPICR---AVIRG---SVRAF M-S--------------------------------------------------------- - >T_nigroviridis_ENSTNIP00000006583 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MRREKDRIRTFRE-------WPADA --AVAPADLAKAGFF---FLGPRDAVQCFCCGGILRCWVQGDSPGDEHRRHFPTCCFILG RAVGNIPLQ---AGSSDSVD---------------------------------------- ----------------------------------------------------EMEAEDSR LTTF-H---NWPT-EASVQPDVLARAGFFY-TGHGDNVKCYYCDGGLRNWEPGDDPWQEH AKWFP--RC---EFLIQTRGQEYISNIQDAHFH-LGDTL----SSSSR------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------DIGPRN ASPLPDMIGGLAASSA-LLSPVV---QTVLQMGFDSSLVESLVQT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KYLLTGRQYTSVSNL----------------VSDVLQ--AEQEDR-- --ETAPQSRVSKSGGCLRWCSYCVCSCCDYLVCAFQSQRRGR------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------APVLLASEHIWPLEKKLSHLSFLREPALIPLTV NE--PSP--EELLRQLQEERTCKVCMDKLVSIVFIP------------------------ -------------------------------CGHLVVCSDCA------------------ ----------------------------------TSLRHCPICR---AVIRG---SVRAF M-S--------------------------------------------------------- - >M_domestica_ENSMODP00000000705 -----------------------------MNLVEN-IMFLSNMNISNL--YELKYDFSCE LYRISTYSAFPVNVPVS-ERSLARAGFYYTGVNDRVKCFCCGLMLDNWKQGDNAIDKHKQ LFPSCAFIQNLTSVNNLESNSQSALSSSLNSA---------------SCS-LSPSSEQSG YFSGSYSS-FPLEPVTSRGVEDLSPLN-TSPYSYSMSTEEARILTYQA-------WPLT- --FLSPLDLARAGFY---YIGPGDMVACFACGGKLSNWEPKDDAMSEHRRHFPHCPFLES QIQET----------------------------------------SR------------- -------------------------------------------FNVS---NLSMQTHAAR VKTF-V---TWPP-QIPVHPEQLANAGFYY-VGCNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EYLIEMKGQQFINQIQASYPH-LLEQ--LLSTSDVP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------VDENAGLP- -IIHFGLGENHAEDAVMMNTSAV---RSALEMGFQRRLIKQTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTTGENYKTVSDL----------------VSDLLK--AEDETR-- --EEDE--QAEEIES--DDLSLIQKNRMALFQHLTC-V--LPVLNCLLTASVINEQEYDV IKQKTQISLQVRELIDTIIVKGNIA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ANIFKKCLRDFDPVLYENLFVEKNMKYIPTEDV SG--------------------KIL----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ - >D_rerio_ENSDARP00000075338 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------GMRSEEERLQTFHN-------WPSDA --AVSPEELARAGFH---YLGYGDTVQCFCCEGILRHWVDGDTPRGEHERHFPTCGLMRG RDVGNVP-----RGSSDSVD---------------------------------------- --------------------------------------------------DSEMETEDNR RSTF-H---NWPT-GAAVQPDTLARAGFFY-TGHGDNVKCFFCDGGLRNWEPGDDPWQEH AKWFP--QC---EYLLQSRGQEYVRNVQQSFFN-MNGRGVRKNDAPQQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------QFMLSQPT FHPGTEVLGGQRSVAAPMLSPVV---QAVLQMGFQHSLVESLVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RFLLTGAHYTSVSDL----------------VTDVLQ--AEEEEE-- --RQTGDTRSGVAHPLFANTLLYQNKIKLYYVCLKKKINMLKHFKSNLLNNYINKINNNN YSHNNFFYFTKKSLKMIFIIIKMQLT---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RIIYFHWFNINDVCLLRDCGDAENTKNDKNKNA VRSDLSP--EEQLRQLQEERTCKVCMDKLVSMVFIP------------------------ -------------------------------CGHLVVCSDCA------------------ ----------------------------------ASLRHCPICR---AVIRG---SVRAF M-S--------------------------------------------------------- - >O_anatinus_ENSOANP00000006435 ----------------------------------MTCNSPEELRTSNPSEVNKDEEFAEE HNRLRTFANFPSTSPVS-SSTLARAGFLYTGEEDVVRCFSCHVAVDRWQYGDSAIGRHRK ISPNCRFVNGCHFKNCA-LPLANASLQNGELGQVE--------------E-CPGNPSHH- ALERSSET-HSDYLLRTRQVVDLSDT--VFPKNPAMCSEEARLETFQN-------WPEYT --LLSPGQLARAGLY---YSGIDDQVECFCCGGKLKNWEPCDRPWSEHKRHFPKCLFVLG RDVGN-----------------------------------------IEIESDSIA----- --SQRSYSNST--------------------------------HFPR---NPAMAEFEAR IHTF-E---TW---TYSIDKELLARAGFYT-LGEQDKVICFHCGGGLTDWKPNEDPWEQH AKWFP--GC---KYLVEQKGQEFINNVHLTQSL-EDSVLEADETPPSL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TKAITIIVFQNLVVGQLAEARAMLYKFYHAHTSICK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------VVTIRKLVYSPLEML----------------TKSVSK--GREANS-- --NP-KSTHYFLFF---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PS VE--ISP--EEELRRLQEEKLCKICMDKNIAVVFLP------------------------ -------------------------------CGHLVACKECG------------------ ----------------------------------EAMGKCPVCC---TLINY---RQKIF M-S--------------------------------------------------------- - >T_rubripes_ENSTRUP00000010298 -----------------------MNPFDNMQLKKEITMEDQQHDSGTLETDS-AEDFSLI TSRLESFRGSNLVQLVP-AERLARAGFHFIGPSDRVRCFSCHKTVENWCTGDRPVERHKE VSPFCKFLSCIYRTSSN-------------------------------PI-PGTSLTNG- SAYNEEAE-DMEYRLRTGQVVDES----IYPVVPHMRSEESRLHTFST-------WPLTA --PVSPCDLAQAGLY---YLGQCDQVQCFCCGGTLADWEIGDSAWAEHSKHFPFCFFILG HDVGN-----------------------------------------IPF-QGSIE----- --EEGSGRL----------------------------------HTSA---AVHMGTFEER LRSF-A---GV---NHPLNIERLARAGFYS-NGTEDMVLCFCCNGGLKGWQPEEDPWEQH ARHYP--GC---RFLLAEKGQEFVNHIQLQMPR-QKKANGFSAATNGT------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DTQTIIHFLRNAIGQALESS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------IRTVLIARHTVNLL-- --LVQKSSPRVTAAMNRQY----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----DDP--LEKLQKLQREKLCKICMDKDIDIVFIP------------------------ -------------------------------CGHLVTCNECS------------------ ----------------------------------VSLIKCPICC---GDIRQ---KVKTY I-T--------------------------------------------------------- - >O_cuniculus_ENSOCUP00000008710 -----------------------------MNIVEN-SIFLANLMKSAN-TFELKYDFSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDKPIEKHRK LYPSCSFVQSLNSVNNWEANSRSTFPSSVTNS---------------THS-FLPSWEHSG YYSGSYSS-LPSNPVNSRANQDFSAFR-VSPYHSAMSTEKARLLTFQS-------WPLT- --FLSPMDLAKAGFY---YVGPGDRVACFACGGKLSNWEPKDDAMSEHLRHFPNCPFVEN QLQDA----------------------------------------SR------------- -------------------------------------------YTIS---NLSMQTHAAR FKTF-F---NWPS-SLLVHPEQLASAGFYY-VGHSDDVKCFCCDGGLRCWELGDDPWVEH AKWFP--RC---EYLIRIKGQEFISXXXXXXXX-XXXX--LLSTSDTP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EDENAEPP- -XXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXX--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------XXXXXXXXXXXXXXX----------------XXXXXX--XXXXXX-- --XXXXXXXXXXXXX--XDLSLIRRNRMALFQHLTC-V--IPILDSLLTSGVINEQEHAV IKQKTQTSLQARELIDIILVKGNYP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ATVFQDCLPGFDPVFSMYLF------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ - >G_gorilla_ENSGGOP00000008442 ----------------------------------MTFNSFEGSKTCVPADINKEEEFVEE FNRLKTFANFPSGSPVS-ASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK VSPNCRFINGFYLENSA-TQSTNSGIQNGQY-KVE--------------N-YLGSRNHF- ALDRPSET-HADYLLRTGQVVDISDT--IYPRNPAMYSEEARLKSFQN-------WPDYA --HLTPRELASAGLY---YTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLG RNL-N-----------------------------------------IRSESDAVS----- --SDRNFPNST--------------------------------NLPR---NPSMADYEAR IFTF-G---TW---IYSVNKEQLARAGFYA-LGEGXKVKCFHCGGGLTDWKPXEDPWEQH AKWYP--GC---KYLLEQKGQEYINNIHLTHSL-EECL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ - >T_nigroviridis_ENSTNIP00000018867 -------------------------------------MEDQRHDNSNLETDS-AEDFSLI KSRLESFRGSSLVQRVP-AERLARAGFYLVGPSDRVRCFSCQKTVENWSREDRPVERHKE VSPVCQFLSCIYGTRPH-------------------------------QL-IDASLANN- SAYNEE------------AVVDES----IYPVAPHMKSEKSRLQTFSS-------WPSAV --PVRPQDLAQAGLY---YLGQNDQVQCFCCGGILANWDAGDSAWGEHNKHFPSCFFILG HDVGN-----------------------------------------IPLQGSGEE----- --EKRVVPPA---------------------------------GAGA---GVHMGTFEER LRSF-A---NV---QHPVNTERLARAGFYS-KG-TDAVLCFSCNGGLKGWRPEEDPWEEH ARHYP--GC---RFLLTEKGQEFVNSIQLRVSG-RNTAVSQAVQDIQVF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------KKIATVHFRVQVIRMDFQQQQW------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------VHTHTKVHTDSSRQ-- --FFFKCETAAGQQNNRIF----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------DIGVCPSCP PE--DDP--KKLLQKLQCEKMCKICLAKDICIVFIP------------------------ -------------------------------CGHLIACEECS------------------ ----------------------------------ESLVSCPVCC---GGITQ---KVKTF L-TYPAKQ---------------------------------------------------- - >G_aculeatus_ENSGACP00000024474 ---------------------------VPPSSILSSSIMCALRQDNQLESDH-MADFSEI NNRLDSFRGSSLAQQVP-AERLARAGFYYTGNADRVCCFSCEKTVENWCRGDTPLERHKE VSPSCIFLSCTQRTNFN-------------------------------LS-CENRLTNG- FSYNEEEE-DLEYRLRRGEVVDES----TYPMAPHMKSEEARLQTLST-------WPSSS --PVRPRDLAQAGLY---YLGQSDRVQCFCCGGMLAGWEVGDTAWEEHNKHFPNCFFMLG HDVGN-----------------------------------------IPLHRGGVE----- --EENSGRQ----------------------------------HASA---CVPMGSFEKR LGSF-A---GV---LHPIDHERLARAGFYS-AGTGDRVLCFRCGGGLKGWQPEEDPWEEH AKHYP--GC---SFLLTEKGQEYVNSIQLQDPR-RNRTNGFSGHGNGK------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------KGAAVGHGSEGRWDD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----VDP--LEKLRELQREKLCKICMDRDIGIVFIP------------------------ -------------------------------CGHLVTCTKCS------------------ ----------------------------------ESLIKCPICC---GAITQ---KIQTY I-A--------------------------------------------------------- - >M_domestica_ENSMODP00000021022 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------VGPQDRVQCFCCGGMLDNWMAGDSPILEHQRFFPKCQFALS KHTGNIPAQ----DTSDSVDG--------------------QILSQLQRISEEGEGEGNE DTVT---------------------------------------TRPV---YPDMGVEQIR LASF-H---NWPS-AAVVCPQQLARAGFFY-TGQHDHVKCYYCDGGLRNWDRGDDPWREH AKWFP--RC---EFLLQSRGRAYVNSIQDSSS--LLDS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------WGHGEDPQEVAPTSTPASVPM------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------ASESTP--PRRESQ-- --PEQITETDPLSVF--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LYLCSLTLST GP--LST--EQQLQQLKEERTCKVCMYQVVSIVFVP------------------------ -------------------------------CGHL-VCSECA------------------ ----------------------------------PNLQQCPICR---AAIHG---SIRTF L-S--------------------------------------------------------- - >A_carolinensis_ENSACAP00000011315 -----------------------------------------------------------E LSRQQTFASFPSDCPVS-SAALAQAGFFYTGERDQVKCFSCHTMVEGWQEGDSAIERHRT IFPECRFINDIDIGRNN-TYSLLNCQHASEN-----------------GS-ASTSQQQP- SLDESSDL-DADYLLRTGQVVDLSGS--LYPRNPAMCSEEARLRTFHN-------WPPYA --PVTPQDLAHAGLY---YTGIGDQVECFCCGGKLKNWEPSDQAWSEHRRHFPRCFFVLG HDLNR------------------------------------------------------- -------SNNV--------------------------------VLPQ---NPCMADYETR LKTF-V---AW---HYLVSKEQLARAGFYS-IGNGDSVACFHCGGGLQEWKAYEDAWEQH AKWFP--GC---KYVLEEKGQDFVNRV--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ - >G_gallus_ENSGALP00000009239 ------------------------------------------------------------ -------------------------------------------------MADTAPVEGTH LRATC------------------------------------------------------- ----------------------------CHLFNYSMRDEARRLRTFSQ-------WPRSS --PVSAWDLAKAGFF---FVGPGDQVQCFSCGGILKDWEPGDCPIVEHLKFFPFCKFIYH GAVWNQQV--PLQGVFDSVDG--------------------QILSLLQRIDSEETALP-- -------------------------------------------NQPE---YPEMVTEEMR LSTF-Q---NWPQ-YTEMRPEQLARAGFFY-TGQGDVVRCFYCDGGMRNWAFGDDPWREH AKWYP--RC---EFLLRSMGREFVSSIFTDECL--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------SKEESP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----LST--EEQLRRLQEERMCKVCMDRDVSVVFVP------------------------ -------------------------------CGHLVACGECA------------------ ----------------------------------LNLRLCPICR---AVIQG---SVRTF M-S--------------------------------------------------------- - >D_rerio_ENSDARP00000013586 ---------------------------FPPQRNLVTTNMAHSTHNGELESDNVAADWSVM KNRVNSFQRFPYSEDIS-AQRLARAGFYFTGEGDRVQCFSCSATVQNWNRGDTPLERHQL ASPDCRFLSCAHGMRNS-------------------------------NS-IQS------ PDYDEEAE-NREFLLRTGEVVDES----MYPVVPHMKSEEARLSTFNN-------WPADS --PVRPEDLAEAGMY---YIGIDDNVQCFCCGGGLSGWEQGDDPWSEHAKYYSNCFFFLG HNVGN-----------------------------------------VPLTTPR------- -------------------------------------------PRAN---VHPTDTFEGR LDSF-K---GR---QHPIDPERLARAGFYS-TGEQDRVMCFRCGGGVKAWMPDEDPWEEH ARHYP--GC---SFLLAEKGEEYVSSVQLRYPK-RPTQNGFSSHESGS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SAQALIHG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SSDMFE---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ KA--DDP--MTELEKLQREKLCKVCMDSDISIVFIP------------------------ -------------------------------CGHLVTCQKCS------------------ ----------------------------------ASLDKCPICC---ATITQ---KIKTY N-A--------------------------------------------------------- - >C_intestinalis_ENSCINP00000002256 ----------------------------------------------------------ME SYRLSTFMKYPQDTPVN-PRHLAAAGFHYTGYKDRVKCFCCGLCVESWCVGDD-VKSPRW HRSNCEFILGQDCGNQP-I-DHMVWLQVVCSATLC---------DHLVQL-GQG------ ------------------------------------------------------------ --GIYSETLA-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------GYVT---CPYMRNEESR FETFDH---RWPASNVRASPRQIAKAGFFF-LGDRDRVKCWYCNGGLQNWDPDDEPWTEH AKWFP--TC---EFLLQRKGPDFVHRMVSLYPN-LPRP--ILRGPFDV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------PPRA-----------------EVA KQQEQVN--------KFMLGDLV---KSATEMGFETSVIRRVVTR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RLTSGGNLYTSVADL----------------VDDITA--NENEPN-- --SDDDDETNASQPSQTTTVKTPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ VT--PSM--EARIRELQEERKCKICLDKVADIVFVP------------------------ -------------------------------CGHLCTCTECA------------------ ----------------------------------EALRKCPICR---SKIER---GIKTY M-S--------------------------------------------------------- - >G_gorilla_ENSGGOP00000008137 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------RNSF---------------AHS-LSPTLEHSS LFSGSYSS-LSPNPLNSRAIEDISSSR-TNPYSYAMSTEEARFLTYHM-------WPLT- --FLSPSELARAGFY---YIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLEN SL-ET----------------------------------------LR------------- -------------------------------------------FSIS---NLSMQTHAAR MRTF-M---YWPS-SVPVQPEQLASAGFYY-VGRNDDVKCFCCDGGLRCWESGDDPWVEH AKWFP--RC---EFLIRMKGQEFVDEIQGRYPH-LLEQ--LLSTSDTT------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GEENADPP- -XXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXX--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------XXXXXXXXXXXXXXX----------------XXXXXX--XXXXXX-- --XXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXX-X--XXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXX----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------XXXXXXXXXXXXXXXXXXXXXDKNMKYIPTEDV SG--LSL--EEQLRRLQEERTCKVCMDKEVSVVFIP------------------------ -------------------------------CGHLVVCQECA------------------ ----------------------------------PSLRKCPICR---GIIKG---TVRTF L-S--------------------------------------------------------- - >T_guttata_ENSTGUP00000007779 ------------------------------------------------------------ -------------------------------------------------MGDAAPAQQPE PRAAR------------------------------------------------------- ----------------------------RRLFEASMRSVARRLRTFQQ-------WPRTA --PVSARDLVEAGFF---YLGPGDEVQCFCCGGILKDWRPGDCPMIEHLHFFPSCKYLSG EDVGNQEML-SLQEIFDTVDG--------------------QFLSVLQGIVSEETAQP-- -------------------------------------------NEPE---YPEMVTEEMR LSTF-E---NWPQ-NSSMHPEQLARAGFFY-TGRGDVVRCFYCDGGVRSWSFGDDPWREH AKWYP--EC---EFLLHSRGREFVNSVQATFSI--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GKDESQ-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----LST--EEQLRRLREERTCKVCMDKDVSVVFVP------------------------ -------------------------------CGHLVACEECA------------------ ----------------------------------LNLRLCPICR---AGIQG---RVRAF M-S--------------------------------------------------------- - >D_melanogaster_FBpp0075254 ------------------------------------------------------------ --MASVVADLPSYGPIA------------------------------------------- ------------------------------------------------------------ ----------FDQVDNNTNATQLFKNNINKTRMNDLNREETRLKTFTD-------WPLD- --WLDKRQLAQTGMY---FTHAGDKVKCFFCGVEIGCWEQEDQPVPEHQRWSPNCPLLRR RTTNNVPINAEALDRILPPISYDICGANDSTLEMREHAYAEGVIPMSQLIQSIGMNAVNA AGSVTGTAAPQPRVTVATHASTATQATGDVQPETCRPSAASGNYFPQ---YPEYAIETAR LRTF-E---AWPR-NLKQKPHQLAEAGFFY-TGVGDRVRCFSCGGGLMDWNDNDEPWEQH ALWLS--QC---RFVKLMKGQLYIDTVAAKPVL-AEEKEESSSIGGVA------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VASTQASEEEQ-- --QTSLSSEEAVSGDVAPSVAPT------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AATRIFNKIVEATAVA TP--STN--SSGSTSIPEEKLCKICYGAEYNTAFLP------------------------ -------------------------------CGHVVACAKCA------------------ ----------------------------------SSVTKCPLCR---KPFTD---VMRVY F-S--------------------------------------------------------- - >O_latipes_ENSORLP00000010149 ------------------------------------------------------------ ---------------VS-PLQLAEAGFLFTGVSDRVRCFSCQKTVENWSQEDQPVDRHIQ VSPSCTFLRCTHFNRFK--------------------------------SNPHMPLSNG- GLHDGTEG-YIDYQLRTRAIVDET----PYPRNRNMKSEEARLETFSS-------WPRSA --PVRPRDLAQAGLF---YLGKEDKVECFSCGGKLSGWKPGDTPWNEHEKHFSHCFYILG HDVGN-----------------------------------------VPLERDGGE----- --NEETGSRN---------------------------------QHRT---PVNLENLDER LGTF-A---RV---QHPIDHELLAKAGFYSKVGEGDEVICFRCGGGLKDWDPEDNPWEEH AKYYP--GC---SFLLSEKGQEFVNTIQLQEPK-YSQQVRHIISPHLR------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------NLFLKLLHFPSFCRNTKKVYFVLCLAYSLLKSWWGSTF------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LMSSDKRIYKKLQNI----------------KMDFLKRRKLAEPF-- --EKENLSQGSATFSTCRANQLWIFHRNKTVIKINLFEIVRTFNRGLHDFLSSLYLSARN LMKNILVFFNMRATKSFVGVKLKVK----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------KHYLLQFYINYIRTGL TI--ENP--LEELEKLRQEKRCKICLDENACIVFIP------------------------ -------------------------------CGHLASCKACS------------------ ----------------------------------NKLNQCPICC---AAIAQ---KIRTF I-A--------------------------------------------------------- - >P_troglodytes_ENSPTRP00000019640 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MTGYEAR LITF-G---TW---MYFVNKEQLARAGFYA-IGQEDKVQCFHCGGGLANWKPKEDPWEQH AKWYP--GC---KYLLEEKGHEYINNIHLTRSL-EGALVQTTKKTPSL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TKRINDTIFPNPML---QEAIRMGFDFKDVKKIMEE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RIQTSGSNYKTLEVL----------------VADLVS--AQKDTT-- --EN-ESNQTSL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q RE--ISP--EEPLRRLQDEKLCKICMDRHIAVVFIP------------------------ -------------------------------CGHLVTCKQCA------------------ ----------------------------------EAVDRCPMCS---AVIDF---KQRVF M-S--------------------------------------------------------- - >H_sapiens_ENSP00000321377 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MTGYEAR LITF-G---TW---MYSVNKEQLARAGFYA-IGQEDKVQCFHCGGGLANWKPKEDPWEQH AKWYP--GC---KYLLEEKGHEYINNIHLTRSL-EGALVQTTKKTPSL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TKRISDTIFPNPML---QEAIRMGFDFKDVKKIMEE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RIQTSGSNYKTLEVL----------------VADLVS--AQKDTT-- --EN-ELNQTSL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q RE--ISP--EEPLRRLQEEKLCKICMDRHIAVVFIP------------------------ -------------------------------CGHLVTCKQCA------------------ ----------------------------------EAVDRCPMCS---AVIDF---KQRVF M-S--------------------------------------------------------- - >O_latipes_ENSORLP00000012199 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MRRERER LQTF-Q---NWPD-EAPVTSEDLAKAGFYF-LGSEDKVKCFFCDGGLRNWEPGDDPWQEH AKWFP--RC---EFLIHSRGQDYINNIQDAHFH-LGNSGEKLLYLHFK------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LADMVGGLGASSA-MLSPVV---QTVLQMGFEDSLVQSLVQT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KYLLTGQHYTSVSDL----------------VTDVLQ--AEEEER-- --QRGANSRGS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AV KE--ASP--EELLRQLQEERTCKVCMDKLVSIVFIP------------------------ -------------------------------CGHLVVCGDCA------------------ ----------------------------------ASLRHCPICR---AVIRG---SVRAF M-S--------------------------------------------------------- - >C_intestinalis_ENSCINP00000010449 ------------------------------------------------------------ ----------------------------MQARMMDIRCDGLRVVHNDGRLVPSATNSERE ------------------------------------------------------------ ----------------------------LYTRPGDPYYESYRLATFTN-------YPNQ- --NINVRQVARAGFY---FISYQDQVKCFSCGQICEDLQQYDD-MSLPQWHLPDCEHLHS LQPNRNNHANTPVQSGLSRPN--------------------ENATFRSLPTRRPA----- --HSNVHSSSSLPRQPTTITINQPRIRSTFTIHEHSNIDLFPCNRPE---SPHMRSVEQR LQTFTRS--NWPAHRVRASILDISRAGLFY-LGNSDRTKCWYCNGGLQNWEPNDDPWYEH AKWFP--EC---EFLLQQKGIEYVYRVSSQFPN-LQRPVIVRSQPQPS------------ ------------------------------------------------------------ ------------------------------------------------------------ --VTIHINRPGRTTMPTASTTHTTSSTTRISAPRSTVVSGPQFLPPMIPGPSINIIDPRE QPRSREEE----LNRYITTSPYI---AVARGMGFDDEAIRSTLRR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------QHEQSQRFFSSAEEL----------------VDALLN----QSNI-- --TSAPQIPSSSTAGA-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TG GP--ITP--LEELRQLEQSRMCKVCHRNQANMVLLP------------------------ -------------------------------CGHVACCTTCG------------------ ----------------------------------NDVTNCPVCL---ADITD---RVRSY I-G--------------------------------------------------------- - >C_intestinalis_ENSCINP00000000487 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------MSIELFKEENRRETFKT-------WSAAF -NDEFVKELARSGFF---YLGNLDRTQCFSCSGVLRNWRASDDVNVEHFRHFPHCKMGSN SESKNVPLPLDHPIDV-------------------------DDIPEPPDPSPKEQENLVK MFTL---------------------------------------GAPM---NPHMRSLDAR VATFDR---RWPARKVKASATHIAKAGFYF-LGDRDRAKCWYCNGGLQNWDANDEPWVEH AKWFP--GC---EFVLRNKGIAFVHEIYTNNPN-LNRPEIQNARSEYL------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TSPKKNGGVMISQTATITAGDVLANYLPPPPPD GVERSPETGSATDVDAMMKNEVV---SVVTSMGFGHDLIRKAVEK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------HISNNGSNPPTTEGL----------------LELILQ--LDENDD-- --VIADDVINGDVMQDDIGAI--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGIVISQGEGVETKSSLKRNNDKAEQDSDQKPM KQQKFDTNAFEELESLEMERRCRACRNHVADTVVMP------------------------ -------------------------------CGHLCFCSSCS------------------ ----------------------------------SSSKRCGLCR---EKIQS---VMKVY L-S--------------------------------------------------------- - >A_aegypti_AAEL009074-PA ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MAG VMMAQVLS-TPRDFTDNKVKEDNAYGHTATSVPISYHTEVARLESFRG-------WMVS- --FISKTELARYGFY---YVGPNDMVKCYFCRVEIGLWEPNDNVLSEHLRWSPYCPLLRK RQTNNVPIDASFLDQLPEPSY--------------------DTCGIRIRENSVAENAYSS SDRSSSGSLTSPPSSLTSESSMASNGPVVQQLSAPVLPQQ---KLPE---YPNYAIEAKR LESY-E---DWPK-FMKQKPKELSDAGFFY-TGKSDRVKCFSCGGGLKDWEAEDEPWEQH AMWYS--NC---EYLKLMKGEAYIAHCLAKKES-SSEENGSDVGPSNS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PQPSTSGVV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SAATSSLQSSQSSS-- --LSVSAEEDNTAM---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------VG CS--SDE--DEPNRKLDTSRTCKICYVNEYNTAFSP------------------------ -------------------------------CGHVVACAKCA------------------ ----------------------------------SSVTKCPLCR---KPFTN---VMRIY L-M--------------------------------------------------------- - >A_gambiae_AGAP007294-PA ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------M- AHALSLPA-PPIDLPDNKHKDDDL----ACMSPEYFHIEENRLRSFTSR------WPVT- --FISPNVLARYGFY---YVGTDDTVKCYFCRVEIGLWEPQDDVIQEHLRWSPYCPLLKK RPTNNVPLNANYLDAVPEPSF--------------------DTCGISVRHNSLM------ -------------------------------------------RRPE---YPNYAIEADR LKSY-E---DWPT-SLKQKPQQLSDAGFFY-TGMSDRVKCFSCGGGLKDWEQEDDPWQQH AIWYS--NC---HYLQLMKGREFIQKCNELKEA-ASASS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AASTSSAMSSASSQ-- --PSTDEGEDDA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GGDRRVPSDGKICKICFVNEYNTAFMP------------------------ -------------------------------CGHVVACAKCA------------------ ----------------------------------SSVSKCPLCQ---QPFIN---VLRLY L-S--------------------------------------------------------- - >G_gorilla_ENSGGOP00000007398 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MTGYEAW LITF-G---TW---MYSVNKEQLARAGFYA-IGQEDKIQCFHCGGGLANWKPKEDPWXQX AKWYP--GC---KXLLEEKGHEYINNIHLTRSL-EGALVQTTKKTPSL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TKRISDTIFPNPML---QEAIRMGFDFKDIKKIMEE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KIQTSGSNYKTLEVL----------------XADLVS--XQKDTT-- --EN-ESNQTSL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q RE--ISP--XEPLRRLQEEKLCKICMDRHIAVVFIP------------------------ -------------------------------CGHLVTCKQCA------------------ ----------------------------------EAVDRCPMCN---AVIDF---KQRVF M-S--------------------------------------------------------- - >M_mulatta_ENSMMUP00000012096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MGPEDSAKCPRHGPQLCRWAAGDGPARERCGPRSLGSPALG LDSCR---------AWDHVDG--------------------QILGQLRPLAEEEEEEGAG AMSP---------------------------------------RGPA---FPGMGSEELR LASF-Y---DWPL-TAGVPPELLAAAGFFH-TGQQDKVRCFFCYGGLQSWKRGDDPWTEH AKWFP--SC---QFLLRSKGRDFVHSVQETHSQ-LLGS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------WDPWEEPEDAAPVAPSVPAPG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------DPELPT--PRREVQ-- --SESAQEPGGASPA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------QAQSGWWVLEPP GA--RDV--EEQLRRLQEERTCKVCLDRAVSIVFVP------------------------ -------------------------------CGHL-VCAECA------------------ ----------------------------------PSLQLCPICR---APVRS---RVRTF L-S--------------------------------------------------------- - >G_gorilla_ENSGGOP00000008152 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MGPKDSAKCLHRGPQPSHWAAGDGPTQERGGPRSLGSPVLG LDTCR---------AWDHVDG--------------------QILGQLRPLTEEEEEEGAG ATLS---------------------------------------RGPA---FPGMGSEELR LASF-Y---DWPL-TAEVPPELLAAAGFFH-TGHQDKVRCFFCYGGLQSWKRGDDPWTEH AKWFP--SC---QFLLRSKGRDFVHSVQETHSQ-LLGS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------WDPWEEPEDAAPVAPSVPASG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------YPELPT--PRREVQ-- --SESAQEPGGVSPA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------QAQRAWWVLEPP GA--RDV--EEQLRRLQEERTCKVCLDRAVSIVFVP------------------------ -------------------------------CGHL-VCAECA------------------ ----------------------------------PSLQLCPICR---APVRS---RVRTF L-S--------------------------------------------------------- - >P_troglodytes_ENSPTRP00000023641 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LG LDTCR---------AWDHVDG--------------------QILGQLRPLTEEEEEEGAG ATLS---------------------------------------RGPA---FPGMGSEELR LASF-Y---DWPL-TAEVPPELLAAAGFFH-TGHQDKVRCFFCHGGLQSWKRGDDPWTEH AKWFP--SC---QFLLRSKGRDFVHSVQETHSQ-LLGS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------WDPWEEPEDAAPVAPSVPASG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------YPELPT--PRREVQ-- --SESAQEPGGVSPA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------QAQRAWWVLEPP GA--GDV--EAQLRRLQEERTCKVCLDHAVSIVFVP------------------------ -------------------------------CGHL-VCAECA------------------ ----------------------------------PGLQLCPICR---APVRS---HVRTF L-S--------------------------------------------------------- - >C_intestinalis_ENSCINP00000000510 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------MSIELFKEENRRETFKT-------WSAAF -NDEFVKELARSGFF---YLGNLDRTQCFSCSGVLRNWRASDDVNVEHFRHFPHCKMGSN SESKNVPLPLDHPIDV-------------------------DDIPVPPDPSPKEQEDLVK MFTL---------------------------------------GAPM---NPHMRSLDAR VATFDR---RWPARKVKASATHIAKAGFYF-LGDRDRAKCWYCNGGLQNWDANDEPWVEH AKWFP--GC---EFVLRNKGISFVHEIYTNNPN-LNRPEIQNARSEYL------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TSPKKNGGVMISQTATITAGEVLANYLPPPPPD GVERSPETGSATDVDAMMKNEVV---SVVTSMGFGHDLIRKAVEK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------HISNNGSNPPTTEGL----------------LELILQ--LDENHD-- --VIADDVINGDVMQDDIGAI--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGIVISQGEGVETKSSLKRNNDKAEQDSDQKPM ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ - >H_sapiens_ENSP00000217169 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MGPKDSAKCLHRGPQPSHWAAGDGPTQERCGPRSLGSPVLG LDTCR---------AWDHVDG--------------------QILGQLRPLTEEEEEEGAG ATLS---------------------------------------RGPA---FPGMGSEELR LASF-Y---DWPL-TAEVPPELLAAAGFFH-TGHQDKVRCFFCYGGLQSWKRGDDPWTEH AKWFP--SC---QFLLRSKGRDFVHSVQETHSQ-LLGS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------WDPWEEPEDAAPVAPSVPASG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------YPELPT--PRREVQ-- --SESAQEPGGVSPA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------EAQRAWWVLEPP GA--RDV--EAQLRRLQEERTCKVCLDRAVSIVFVP------------------------ -------------------------------CGHL-VCAECA------------------ ----------------------------------PGLQLCPICR---APVRS---RVRTF L-S--------------------------------------------------------- - >C_intestinalis_ENSCINP00000020067 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MAEIDRQDITGLA------SP--- --SLTQHKEAKTQILPGRNCCASNSVTAFDC----------------------------- ------------------------------------------------------------ -------------------------------------------KHPY---TKNMENFRER IRTF-I---SWPRGVTKATPVEIAKAGFFY-LKERDRAKCFYCNGGLQNWEPNDEPWFEH AKWFP--NC---DFLLREKGIEFVQNVAGRFPN-LNRP--LLNDQATP------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KPSTSNLQLPAPATSKQTEVP QNSASHIEITRPTLEEAMESELV---LAVSGFGFERELVQLVVER--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LLQETGNVNCTIMEL----------------VTATQQ--LEQKQM-- --EENAMEVVESFNVNQEK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------PEMACAQINLSTSPTDSFPMQTP--------------------- ---------------------------GNFTEQQVPGSKKMMYVKQKEVSVPELS---EQ SL--AQQ--RSQLQNLKDEMRCKICLDNPMDCILLE------------------------ -------------------------------CGHVCTCLECS------------------ ----------------------------------QGIRTCPICR---QKITK---IMKIY R-NY-------------------------------------------------------- - >P_troglodytes_ENSPTRP00000048273 MATQQKASDERISQFDHNLLPELSALLGLDAGQLAKELEEKEQKERAKMQKGYNSQMRSE AKRLKTFVTYEPYSSWI-PQEMAASGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKR FHPDCGFLLNKDVGNIA-KYDIRVKNLKSRL----------------------------- -----------------------------RGGKMRYQEEEARLASFRN-------WPFYV -QGISPCVLSEAGFV---FTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRS KKSSEEITQYIQSYKGFVDIT--------------------GEHFVNSWVHRELP----- --MAS--------------------------------------AYCN---DSIFAYEELR LDSF-K---DWPR-ESAVGVAALAKAGLFY-TGIKDIVQCFSCGGCLEKWQEGDDPLDDH TRWFP--NC---PFLQNMKSSVEVTPDLQSRGE-PCELLETTSESNLEDSIAVDHIVP-- ------------------------------------------EMAQGEARWFQEAKNLNE QLRAAYTSASFRHMSLLDISSDLATD-HLLGCDLSIASKHISKPVQEPLVLPEVFANLNS VMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLL EKEGSVTEMCMRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTD RARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLF VAAICAHWFQYPFDP-SFDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFSC CFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDSD RQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL-- --ENISENDDYLKHQPEISLQMQ-LLRGLWQICPQAYF--SMVSEHLLVLALKIAYQSNT VAACSPFVLQFLQGRTLTLGVLNLQ------YFFDHPESLSLLRSIHFSIRGNKTSPRAH FSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYW KLSPKQYKIPCLEVNVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALEL SKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVD LEGNINVFSVIPEEFPNFHHMEKLLI-QISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSD FE--SLMTMLVSCKKLTEIKFLDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKF AYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAI S-GGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLKELDISRHFTECIKAQATTVKSL S-QCVLRLPRLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-- - >E_caballus_ENSECAP00000017749 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SMGPEDKAKCWCRGLELSHQAAGGSPMQGHHRPHCLALSWGG R---------------DHVDG--------------------QILGQLHPLAEEEEEGAGA VAAPS--------------------------------------TRPA---FPRMGSEELR LASF-C---HWPL-TAVVRPELLAAAGFFH-TGWQDKVRCFFCHGGLQSWERGDDPWTEH AKWFP--RC---EFLLQTKGRDFVCRVQESCCH-QLSS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------WDQLEEPEDAAPSVPSTPVHR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GPDPPM--PRREAQ-- --S-GAREP--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ GA--QNV--EEQLQRLREERTCKVCLDRAVSVVFVP------------------------ -------------------------------CGHL-VCAECA------------------ ----------------------------------PNLQLCPICR---APIDS---CVRTF L-S--------------------------------------------------------- - >M_musculus_ENSMUSP00000113890 MAAQGEAVEEIICEFDDDLVSELSTLLRVDALSVLKRQQEEDHKTRMKMKKGFNSQMRSE AKRLKTFETYDKFRSWT-PQEMAAAGFYHTGVKLGVQCFCCSLILFSTRLRKLPIENHKK LRPECEFLLGKDVGNIG-KYDIRVKSPEKML----------------------------- -----------------------------RGDKARYHEEEARLESFED-------WPFYA -HGTSPRVLSAAGFV---FTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQS KKSPEEITQYVQSYEGFLHVT--------------------GEHFVNSWVRRELP----- --MVS--------------------------------------AYCN---DSVFANEELR MDTF-K---DWPH-ESPGAVEALVKAGLFY-TGKRDIVQCFSCGGCMEKWAEGDNPIEDH TKFFP--NC---VFLQTLKSSAEVIPALQSHCA-LPEAMETTSESNHDDAAAVHSTVVDV SPSEAQELEPASSLVSVLCRDQDHSEAQGRGCASSGTYLPSTDLGQSEAQWLQEARSLSE QLRDTYTKATFRHMNLPEVYSSLGTD-HLLSCDVSIISKHISQPVQGSLTIPEVFSNLNS VMCVEGEAGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSITPGQELAKIICAQLL GAGGCISEVCLSSIIQQLQHQVLFLLDDYSGLASLPQALHTLITKNYLSRTCLLIAVHTN KVRGIRPYLDTSLEIKEFPFYNTVSVLRKLFSHDIMRVRKFINYFGFHEELQGIHKTPLF VAAVCTDWFKNPSDQ-PFQDVALFKAYMQYLSLKHKGAAKPLQATVSSCGQLALTGLFSS CFEFNSDNLAEAGVDEDEELTTCLMSKFTAQRLRPVYRFLGPLFQEFLAAVRLTELLSSD RQEDQDLGLYYLRQINSPLKAMSIYHTFLKYVSSHPSSKAAPTVVSHLLQLVDEKESL-- --ENMSENEDYMKLHPEALLWIE-CLRGLWQLSPESFS--LFISENLLRICLNFAHESNT VAACSPVILQFLRGRTLDLKVLSLQ------YFWDHPETLLLLKSIKISLNGNNWVQRID FSLIEKSFEKVQPPTIDQDYAIAFQPINEVQKNLSEKKHIIKKYEDMKHQIPLNISTGYW KLSPKPYKIPKLEVQVTNTGPADQALLQVLMEVFSASQSIEFRLSDSSGFLESIRPALEL SKASVTKCSMSRLELSREDQKLLLTLPTLQSLEVSETNQLPDQLFHNLHKFLGLKELCVR LDSKPDVLSVLPGEFPNLHHMEKLSI-RTSTESDLSKLVKLIQNSPNLHVFHLKCNFLSN CE--PLMTVLASCKKLREIEFSGRCFEAMTFVNILPNFVFLKILNLRDQQFPDKETSEKF AQALGSLRNLEKLFVPTGDGIHQVAKLIVRQCLQLPCLRVLVFAETLDDDSVLEIAKGAT R-GGFQKLENLDLTLNHKITEEGYRNFFQVLDNLPNLKNLDISRHIPECIQIQAITVKAL G-QCVSRLPSLTRLGMLSWLLDEEDIKVINDVKERHPQSKRLTVHWRWVVPFSPVIQK-- - >X_tropicalis_ENSXETP00000030727 -----------------------------NEILDR-RPDLAKRLKSNPSMCKITLEFSCE LYRLSTFSSFPSNTHVS-ERNLAKAGFYYTGQDDKVKCFTCGLMLDNWKKGDNAFEKHKK LYPSCSFIQNVPSV-NLGASLYSAFSPPASNS---------TP----MHA-ASAENDKVE AITLKYSS-IPQDPVTLRGIEDLSHVR-ISEY---MYTEEARLNSFQE-------WSNM- --FLTPAELAKAGFY---FVGPGDKVACFTCDGKLNNWEPNDNAMSEHRRHFPNCPFVKS STRVS----------------------------------------SR------------- -------------------------------------------FSVS---NVSMQASSAR LKTF-A---SWPP-RIPISPTRLAEAGFYY-VGRNDDV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ - >M_musculus_ENSMUSP00000112867 MAEHGESSEDRISEIDYEFLAELSARFGMNLVQLAKSQEEEDHKERMKMKKGFNSQMRSE AKRLKTFESYDTFRSWT-PQEMAAAGFYHTGVKLGVQCFCCSLILFGNSLRKLPIERHKK LRPECEFLQGKDVGNIG-KYDIRVKSPEKML----------------------------- -----------------------------RGGKARYHEEEARLESFED-------WPFYA -HGTSPRALSAAGFV---FTGKRDTVQCFSCGGSLGNWEEGDDPWKEHAKWFPKCEFLQS KKSSEEIAQYIQDYEGFVHVT--------------------GEHFVKSWVRRELP----- --MVS--------------------------------------AYCN---DSVFTNEELR MDMF-K---DWPQ-ESPVGFEALVRAGFFY-TGKKDIVRCFSCGGCLEKWAEGDDPMEDH IKFFP--EC---VFLQTLKSSAEVIPTLQSQYA-LPEATETTRESNHDDAAAVHSTVV-- ------------------------------------------DLGRSEAQWFQEARSLSE QLRDTYTKTSFCHMNLPEVCSSLGTD-HLLGCDVSIISKHVSQPVQGALTIPEVFSNLSS VMCVEGEAGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSITPDQGLANIICTQLL GAGGCISEVCLSSSIQQLQHQVLFLLDDYSGLASLPQALHTLITKNYLFRTCLLIAVHTN RVRDIRPYLGTSLEIQEFPFYNTVFVLRKFFSHDIICVEKLIIYFSENKDLQGVYKTPLF VAAVCNDWNQNASAQDDFQDVTLFHSYMQYLSLKYKATAESLQATVSSCGQLALTGLFSS CFEFNSDDLAEAGVDEDVKLTTFLMSKFTAQRLRPVYRFLGPLFQEFLAAVRLTELLSSD RQEDQDLGLYYLRQIDSPLKAINSFNIFLYYVSSHSSSKAAPTVVSHLLQLVDEKESL-- --ENMSENEDYMKLHPQTFLWFQ-FVRGLWLVSPESFS--SFVSEHLLRLALIFAYESNT VAECSPFILQFLRGRTLALRVLNLE------YFWDHPESLLLLRSLKVSINGNKMSSYVD YS-FKTYFENLQPPAINEEYTSAFEHVSEWRRNFAQDEEIIKNYENIWPRALPDISEGYW NLSPKPCKIPKLEVQVNNMGPADQALLQVLMEVFSASQSIEFHLFNSSGFLESIRPALEL SKASVTKCSMSRLELSRAEQELLLTLPALQSLEVSETNQLPDQLFHNLHKFLGLKELCVR LDGKPDVLSVLPEEFLNLHHMEKLSI-RTSTESDLSKLVKFIQNFPNLHVFHLKCDFLSN CE--SLMTALASCKKLREIEFSGQCFEAMTFVNILPNFVSLKILSLKGQQFADKETSEKF AQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLPCLRVLAFHDILDDESVIEIARAAT S-GSFQKLENLDISMNHKITEEGYRNFFQALDNLPNLQMLNICRNIPGRIQVQATTVKAL G-HCVSRLPSLTRLGMLSWLLDEEDMKVINDVKERHPQSKRLTIFWKWIVPFSPVVLE-- - >A_gambiae_AGAP011326-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MS--- --SASGSEVQPA------------------------------------------------ ------------------------------------------------------------ -------------------------------------------EMPY---MPEFAVLDAR IRSF-E---SWRF-GHMQNPTRLAVAGFYY-TGTDDEVRCFQCDAGLRDWLVTDDPWQEH ARCFA--EC---TFLRLVFGADTVDEVLRNGIA-GFKNGANTATTPSA------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TVSGPIDETS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SE LA--QRL--REENKRMKQERECKICLTQEAEVVFMP------------------------ -------------------------------CAHLLSCVQCS------------------ ----------------------------------TGVDNCPVCR---AVITH---RFRAF I-C--------------------------------------------------------- - >M_musculus_ENSMUSP00000104503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MFSPADLFRAAVF---SMGPESRARDSVRGPELSHREDGSGRTQEQDKPHCPCNHVLG Q---------------DCLDG--------------------QILGQLRPLSEEEESSGAA FL-----------------------------------------GEPA---FPEMDSEDLR LASF-Y---DWPS-TAGIQPEPLAAAGFFH-TGQQDKVRCFFCYGGLQSWERGDDPWTEH ARWFP--RC---QFLLRSKGRDFVERIQTYTP--LLGS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------WDQREEPEDAVSATPSAPAHG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SPELLR--SRRETQ-- --PEDVSEP--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ GA--KDV--QEQLRQLQEERRCKVCLDRAVSIVFVP------------------------ -------------------------------CGHF-VCTECA------------------ ----------------------------------PNLQLCPICR---VPICS---CVRTF L-S--------------------------------------------------------- - >H_sapiens_ENSP00000194097 MATQQKASDERISQFDHNLLPELSALLGLDAVQLAKELEEEEQKERAKMQKGYNSQMRSE AKRLKTFVTYEPYSSWI-PQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKR FHPDCGFLLNKDVGNIA-KYDIRVKNLKSRL----------------------------- -----------------------------RGGKMRYQEEEARLASFRN-------WPFYV -QGISPCVLSEAGFV---FTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRS KKSSEEITQYIQSYKGFVDIT--------------------GEHFVNSWVQRELP----- --MAS--------------------------------------AYCN---DSIFAYEELR LDSF-K---DWPR-ESAVGVAALAKAGLFY-TGIKDIVQCFSCGGCLEKWQEGDDPLDDH TRCFP--NC---PFLQNMKSSAEVTPDLQSRGE-LCELLETTSESNLEDSIAVGPIVP-- ------------------------------------------EMAQGEAQWFQEAKNLNE QLRAAYTSASFRHMSLLDISSDLATD-HLLGCDLSIASKHISKPVQEPLVLPEVFGNLNS VMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLL EKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTN RARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLF VAAICAHWFQYPFDP-SFDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFSC CFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDSD RQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL-- --ENISENDDYLKHQPEISLQMQ-LLRGLWQICPQAYF--SMVSEHLLVLALKTAYQSNT VAACSPFVLQFLQGRTLTLGALNLQ------YFFDHPESLSLLRSIHFPIRGNKTSPRAH FSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYW KLSPKQYKIPCLEVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALEL SKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVD LEGNINVFSVIPEEFPNFHHMEKLLI-QISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSD FG--SLMTMLVSCKKLTEIKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKF AYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAI S-GGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQATTVKSL S-QCVLRLPRLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-- - >A_gambiae_AGAP007293-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MASAVVSCICREIAEYRVTHDTPEECLNYEVNRLRTFPL-------WTVP- --YIYPEELARWGFF---YTGYRDCVRCYFCRIELGGWDEHDVVIEEHLKWSPHCRLMTK RPTNNVPIDPDFLDQLGEIVP--------------------DTTGTGSTSAWSAA----- --ATAAVAVAMESNRLNRQNELERQSQRTQNDTIPF-------YRQK---YPEYRIGGDR LATF-K---EWPK-SIPQTPTQMADAGFFY-TGKSDVVACYYCGGNLRDWLAEDDPWVEH VRNFS--EC---PYVKLVKTPEFIAECRGEKVT-NSALIASSERSGHG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -N--VSK--DKEQDEVSDEKCCKICYIRPFDTVFIP------------------------ -------------------------------CGHVVACGKCA------------------ ----------------------------------ASTTKCPMCN---ESYTS---VQRIF L-S--------------------------------------------------------- - >M_musculus_ENSMUSP00000058611 MAEHGESSEDRISEIDYEFLPELSALLGVDAFQVAKSQEEEEHKERMKMKKGFNSQMRSE AKRLKTFETYDTFRSWT-PQEMAAAGFYHTGVRLGVQCFCCSLILFGNSLRKLPIERHKK LRPECEFLQGKDVGNIG-KYDIRVKRPEKML----------------------------- -----------------------------RGGKARYHEEEARLESFED-------WPFYA -HGTSPRVLSAAGFV---FTGKRDTVQCFSCGGSLGNWEEGDDPWKEHAKWFPKCEFLQS KKSSEEIAQYIQSYEGFVHVT--------------------GEHFVKSWVRRELP----- --MVS--------------------------------------AYCN---DSVFANEELR MDMF-K---DWPQ-ESPVGVEALVRAGFFY-TGKKDIVRCFSCGGCLEKWAEGDDPMEDH IKFFP--EC---VFLQTLKSSAEVIPTLQSQYA-LPEATETTRESNHGDAAAVHSTVV-- ------------------------------------------DLGRSEAQWFQEARSLSE QLRDNYTKATFRHMNLPEVCSSLGTD-HLLSCDVSIISKHISQPVQEALTIPEVFSNLNS VMCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSITPDQGLANIICAQLL GAGGCISEVCLSSSIQQLQHQVLFLLDDYSGLASLPQALHTLITKNYLSRTCLLIAVHTN RVRDIRLYLGTSLEIQEFPFYNTVSVLRKFFSHDIICVEKLIIYFIDNKDLQGVYKTPLF VAAVCTDWIQNASAQDKFQDVTLFQSYMQYLSLKYKATAEPLQATVSSCGQLALTGLFSS CFEFNSDDLAEAGVDEDEKLTTLLMSKFTAQRLRPVYRFLGPLFQEFLAAVRLTELLSSD RQEDQDLGLYYLRQIDSPLKAINSFNIFLYYVSSHSSSKAAPTVVSHLLQLVDEKESL-- --ENMSENEDYMKLHPQTFLWFQ-FVRGLWLVSPESSS--SFVSEHLLRLALIFAYESNT VAECSPFILQFLRGKTLALRVLNLQ------YFRDHPESLLLLRSLKVSINGNKMSSYVD YS-FKTYFENLQPPAIDEEYTSAFEHISEWRRNFAQDEEIIKNYENIRPRALPDISEGYW KLSPKPCKIPKLEVQVNNTDAADQALLQVLMEVFSASQSIEFRLFNSSGFLESICPALEL SKASVTKCSMSRLELSRAEQELLLTLPALQSLEVSETNQLPEQLFHNLHKFLGLKELCVR LDGKPNVLSVLPREFPNLLHMEKLSI-QTSTESDLSKLVKFIQNFPNLHVFHLKCDFLSN CE--SLMAVLASCKKLREIEFSGRCFEAMTFVNILPNFVSLKILNLKDQQFPDKETSEKF AQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLPCLRVLTFHDILDDDSVIEIARAAT S-GGFQKLENLDISMNHKITEEGYRNFFQALDNLPNLQELNICRNIPGRIQVQATTVKAL G-QCVSRLPSLIRLHMLSWLLDEEDMKVINDVKERHPQSKRLIIFWKLIVPFSPVILE-- - >P_pygmaeus_ENSPPYP00000012543 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MGPKDSAKCLHCGPQPSHWAAGDGPAQEHCGPRSLGSPVLG LDTCR---------AWDHVDG--------------------QILGQLRPLAEEEEEEGAG ATLS---------------------------------------RGPA---FPGMGSEELR LASF-Y---DWPL-TAEVPPELLAAAGFFH-TGQQDKVRCFFCYGGLQSWKRGDDPWTEH AKWFP--SC---QFLLRSKGRDFVHSVQETHSL-LLGS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------WDPWEEPEDAAPAAPSVPASG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------DPELPT--HRREVQ-- --SESAQE---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------P GA--RDV--EEQLRRLQEERRCKVCLDRAVSIVFVP------------------------ -------------------------------CGHL-VCAECA------------------ ----------------------------------PSLQLCPICR---APVRS---RVRTF L-S--------------------------------------------------------- - >P_pygmaeus_ENSPPYP00000017359 MATQQKASDERISQFDHDLLPELSALLGLDAVQFVKEIEEEEQKERAKMQKGYNSQMRSE AKRLKTFVTYEPYSSWI-PQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKR FHPDCGFLLNKDVGNIA-KYDIRVKNLKSRL----------------------------- -----------------------------RGGKMRYQEEEARLASFKN-------WPFYV -QGIPPCVLSEAGFV---FTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQS KKSSEEITQYIQSYQGFVDIT--------------------GEHFVNSWVQRELP----- --MAS--------------------------------------AYCN---DSIFAYEELR LDSF-K---DWPR-ESAVGVAALAKAGLFY-TGIKDIFQCFSCGGCLEKWQEGDDPLDNH TRCFP--NC---PFLQNMKSSAEVIPDLQSHGE-LCELLETTSESNPEDSIAVDPIVP-- ------------------------------------------EMAQGEAQWFQEAKNLNE QLRAAYTSASFRHMSLLDISSDLATD-HLLGCDLSIASKHISKPVQEPLVLPEVFANLNS VMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSFSSTRPDQGLASIICDQLL EKEGSVTEMCMRNILQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRACLLIAVRTD KARDIRRYLETILEIKAFPFYNTVFILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLF VAAICAHWFQYPFDP-SFDDVAVFKSYMERLFLRNKATAELLKATVSSCGELALKGFFSC CFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLESD RQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL-- --ENISENDDYLKHQPEISLKMQ-LLRGLWQICPQAYF--SMVSEHLLVLALKIAYQSNT VAVCSPFVLQFLQGRTLTLGALNLQ------YFFDHPESLSLLRSIHFSIQGNKTSPRAH FSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKEDDVKSYMDMQRRASPDLSTGYW KLSPKQYKIPCLKVNVNDIDAVDHEMLEILMTVFSASQRIELHLNHSRGFIESIRPALEL SKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVD LEGKINVFSVIPEEFPNFHHMEKLLI-QISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSD FE--SLMTILASCKKLTEIKFLDSFFQPVPFVAILPNFISLKILNLEGQQFPDDETSEKF AYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAI N-GGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLQELDISRHFTEVIKTHATTVKSL S-QCVLRLPRLIRLNMLSWLLDADDIALLNVMKERHPQSKYLNILQKWILPFSPIIQK-- - >R_norvegicus_ENSRNOP00000024483 MAEHGEASEDQVSEFDGECLPELSALLGVDAVQLVKSQEEEENKERMKMKKGFNAQMRSE AKRLKTFVTYDAFKSWT-PQEMAAAGFYYTGVRHGVQCFCCSLILFGTSLRKVPIESHRK LRPQCEFLSGKDVGNIG-KYDIRVKNPETLP----------------------------- -----------------------------RGGRARYHEEEARLESFED-------WPFYA -HGTSPRVLSAAGFV---FTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQS KKSTEEINQYIQSYTGFLHVA--------------------GEHFVNSWVRRELP----- --VVS--------------------------------------AYSN---DSVFANEGLR MDTF-K---DWPH-ESSVAVEALVKAGLFY-TGKKDIVQCFSCGGCMENWKEGDDPIEDH TKFFP--NC---VFLQTLKSSAEVIPALQSHCA-CPEAMETTSESNHEDPVAVHSSVA-- ------------------------------------------GLGQSEAQWCQEARSLSE QLRGTYTKASFRHMNLPEAYSSLGTD-HLLGCEVFLISKHVSRPVQVALTIPEVFANLSS VMCVEGEAGSGKTTFLKRIAFLWASGCCPLLNRFQLVFYLSLRSIRADQGLADIICAQLL EAGGCISEVSLSSGIQHLQHQVLFLLDDYSGMDSLPQALDTLITKNYLSRTCLLMAVHTN RVRDIRPYLETVLQIKEFPFYNTISVLRKFFSHNTTRLLEFMVYFGRNEDLQGVHKTPLF VAAVCTDWFQNPSDQ-PFQDVTIFKSYMQYLFLKHKATAGPLQATVSSCGHLALTGLFSS SFEFSSDDLIEAGVDEDEELSTCLMSKFTAQRLRPVYRFLSPLFQEFLAAMRLSELLGSD SQEDQDLGLYYLRQINSPLKAINSYGIFLKYVSDHCSSKAGPKVVSHLLQLVDEKESL-- --ENMSENEDYMKLHPETFLWLH-FLRGLWLNSPESFS--SLLSERLLNIALNFAYQSST VAACSPVILQFLRGRTLALGVLNSQ------YFWDHPESLLLLGSLKVSINGNEISSHVD YS-FKTYFENLQPPAIDKEYTSAFEHISEWKRNFAEDEKIIKHYQNIWPRVLPDISEGYW KLSPKPYKIPRLEVGVNNMGPADQALLHVLMEVFSASQSIEFQLFNSSGFLESIRPALEL NKTSVTKCSMSRLELSRAEQELLLTLPALQSLEVSETNQIPDQLFHNLDKFLGLKELSVR LDGTQDVLSVLPGEFPNLHHMEKLSI-HTFTESDLSKLVKLIQNSPNLHDIHLKCDFLSN CE--SLMAALASCEKLREIEFSGRCFEAMPFVTLLPNFVFLKILNLKGQQFPDKETSEMF AQALGSLRKLEELHLPKGDGIHQVAKLIVQQCLQLPCLRVLAFHHVLDDDSVTEVARVAT S-RGFQKLENLDLSMNHKITEEGYRNFFQALDNLPNLQELNICRHIRECIQVQASTVKAL G-QCVSRLPSLTRLRMLSWLLDEEDMKVINDVKERHPQSKRLTVFWKWIVPFSPVVQE-- - >B_taurus_ENSBTAP00000004317 MATQEKAPEERISQFDYALLPEMSAFLGVNALQFVKEIEEKEHRDREKMQKGFNSQMRSE AKRLKTFVTYNTFRSWT-SQEMAEAGFYLTGTKSGIQCFCCSLILFGTSLQNTPMEHHKK FHPDCEFLLGKDVGNIA-KYDVRVQKPENTL----------------------------- ----------------------------RRDDKARYQEEKARLESFKN-------WPFYA -QGTSPRELSAAGFV---FTGKHDTVQCFSCGGCLGNWEDDDDPWKEHAKWFPKCEFLQS KKSLEEITQYIQSYKGFVDVT--------------------GEHFLNSWVKRDLS----- --VAS--------------------------------------VCCNGSNSSSFVNEELL LQSF-K---SWHP-SYPVGAAALAKAGFFY-TGKSDIVQCYSCGGYLHDWKEGDDPLEEH AKFFP--NC---QFLQSVKSSAEAIPDLQSHDE-LSELTETTNEGNLEESTAVSSIVP-- ------------------------------------------EVAQGEAQWFQEAESLSE HLRKVYTSAPFCHMSLLEISSCLATD-QWLDCDLSFALKHITNPVQEPVVLPEVFANLNS VMCVEGEAGSGKTILLKKIAHLWASGRCPLLNRFRLVFCLSLGSTRPEQGLASVIRDQLL ETKLSVTEMGLRNIIQQLKNQVLFLLDDYKEMCSVPQVIARMIQKKHLSRTCLVITVRTN RAKNIRRYLDTIIEIKAFPFYNTISILRKLFPGDLTRLRKLMVDFGMNQTWQGIQKTPLF VAAVRASWLQNRFHR-SFDSVAVFESYMECLFLKHKTEADLLKATVSSCGDLALKGFFSS CFEFSDEDLIEAGIGEEEDLAMYLMSKFTAQRLRPVYQFLNPAFQEFLAGMRLTELLDSD RQEDQDLGLHYLKRINSTLMVIYPYANFLNCVSRHPSTKAGPKIVSHLLLLVDNKETL-- --ENISENDDYLKHHPEISEVMQ-FFRLIWQLSPQNYL--SLASKHLLALAIRIAYQSNT VAACSPFILQFLRGRTLCLDVLKLQ------YFFDHPESLLLLRSIQVSINGNRLF-KTD -TPLERIFDKSQAPTIEQDYASAFELESEWKQSLDEKHEIIQNFQNMRLNAPPAINTGYW NLPSKQYKIPLLEVHVTNTHAVDQEMLRFLTEVFSAAQHIELHLNHSRGFIENIRPALEQ FRASFTKCCISQCELSAIEQELLLTLTSLESLEVSETTHPQDQLFLSLDKFLCLKELSVN LQ--QDVFSAISEEFLNLHHMEKLLI-QISSKCSPSKLVRLVQNSPNLQVFHLECNSFSD FE--SLVTALASRKKLEEIKFSGQFFQANPFVIVLPNFTSLKILKLGIQYIPDKETAEKF AYALGSLNNLEELILPTGDGIHQMAKLIIQQCQHLQCLQVLQFFKTLDDDSVVEIAKVAI N-GGFQKLKHLDFSMNHKITEEGYRNFFQTLDNLPSLQELTISRHFKECIKVQAATVKSL S-QCVLRLPSLLRLNMLSWLLDAEDITLLTATIKKHPQSKHFILSWKWILPFSPIIQEPI S >C_familiaris_ENSCAFP00000018803 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MGPEDRAKCWCRGPELGRGRLSPCGHTEGRDGRC-ARCWGG R---------------DRVDG--------------------QILGQLRPLAEEEEAGEPR AGP----------------------------------------PRPA---FPGMGSEQLR LASF-S---AWPL-TAVVQPELLAAAGFFH-TGQQDKVRCFFCYGGLQSWEQGDDPWTEH AKWFP--RC---EFLLQTKGRDFVCSVQEACCH-LLGS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------WDPSEEPEDTAPATPSAPVHM------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SPELPT--PRREVQ-- --SEGAREPGKGVEP--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------RPRGCCWVLEPP GA--RDA--EEQLQRLREERVCKVCLDRTVCTVFVP------------------------ -------------------------------CGHL-VCAECA------------------ ----------------------------------PALQLCPVCR---APIRS---CVRTF L-P--------------------------------------------------------- - >A_gambiae_AGAP007291-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MASTVVSCICREIAEYRVTHIVPEECLNYEINRLRTYDLL------WTVP- --YIYPEELARWGFF---YTGHRDCVRCYFCRIELGGWDEHDVVIEEHLKWSPHCRLMTK RPTNNVPIDPDFLDQLGEIVP--------------------DTTGTGSTSAWSAA----- --ATAAAA---ESNRLNRQNELE----RTQNDTIPF-------YRQK---YPQYRIEGDR LATF-K---EWPK-SMPQTPERMADAGFFY-TGKSDVVACFYCGGNLRDWLAEDDPWVEH VRNFS--EC---PYVKLVKTPEFIAECRGEKVT-NSALTAGPEHSGHG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -N--VSK--DKEQDEVSDEKCCKICFTRPFDTVFMP------------------------ -------------------------------CGHVVACGRCA------------------ ----------------------------------ATTTKCPMCN---EPYTS---VQRIY F-S--------------------------------------------------------- - >M_musculus_ENSMUSP00000022142 MAEHGESSEDRISEIDYEFLPELSALLGVDAVQLAKSQEEEEHKERMKMKKGFNSQMRSE AKRLKTFETYDTFRSWT-PQEMAAAGFYHTGVKLGVQCFCCSLILFGNSLRKLPIERHKK LRPECEFLQGKDVGNIG-KYDIRVKSPEKML----------------------------- -----------------------------RGGKARYHEEEARLESFED-------WPFYA -HGTSPRVLSAAGFV---FTGKRDTVQCFSCGGSLGNWEEGDDPWKEHAKWFPKCEFLQS KKSSEEIAQYIQGYEGFVHVT--------------------GEHFVNSWVRRELP----- --MVS--------------------------------------AYCN---DSVFANEELR MDTF-K---DWPH-ESPVAVDALVRAGLFY-TGKKGIVQCFSCGGCMEKCTEGDDPIQEH NKFFP--NC---VFLQTPKSSAEVIPALQSHCA-LPEAMETTSESNHDDPAAVHSTVV-- ------------------------------------------GLGRSEAQWFQEARSLSE QLRDNYTKATFRHMNLPEVCSSLGTD-HLIGCDVSIISKHISQPVQGALTIPEVFSNLSS VMCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSITPDQGLANIICAQLL GAGGCISEVCLSSIIQQLQHQVLFLLDDYSGLASLPQALHTLITKNYLSRTCLLIAVHTN RVRGIRSYLDTSLEIKEFPLSNTVYILKKFFSHNIKRLLEFMVYFGQNEDLQGIHKTPLF VAAVCTDWFENPSDQ-PFQDMALFKSYMQYLSLKHKGAAKPLQATVSSCGQLALTGLFSS CFEFNSDDLAEAGVDEDEELTTCLMSKFTAQRLRPVYRFLGPLFQEFLAAMRLTELLSSD RQEDQDLGLYYLRQINSPLKALTTYNNFLKYVFSHPSSKAGPTVVSHLLHLVDETELL-- --ENTYKNEDYVNHPPGTSRIMK-GLKELWLLSPEYYS--SFVSEHLLRIALNFAYESNT VAECSPFILQFLRGRTLALKVLNLQ------YFRDHPESLLLVKSLEVSINGNKVPKVVD YSVMEKSFETLQPPTIDQDYASAFEQMKEHEKNLSENEETIKSIKNIFPLQPPKISSGYW KLSPKPCKIPRLEVGVTNMGPADQALLQVLMEVFSASQSIEFRLSDSSGFLESIRPALEL SKASVTKCSMSRLELSRAEQELLLTLPALQSLEVSETNQLPDQLFHNLHKFLGLKELCVR LDGKPDVLSVLPGEFPNLLHMEKLSI-RTSMESDLSKLVKLIQNSPNLHVFHLKCDFLSN CD--SLMAVLASCKKLREIEFSGRCFEAMPFVNILPNFISLKILNLISQQFPDKETSEKF AQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLPCLRVLAFHYILDNDSVIEIARVAT S-GGFQKLEKLDLSMNHKITEEGYRNFFQALDNLPNLQNLNICRHIPECIQVQATTVKAL G-QCVSRLPSLTRLHMLSWLLDEEDMKVINDVKERHPQSKRLIIFWKWIVPFSPVVLE-- - >E_caballus_ENSECAP00000002314 MATEEKAPAGRDSRFDHALLQELSALLGIDAVQYAKEMEEEEQREREKMQQGFNSRMRSE AKRLKTFATYEAYSSWT-PQEMAAAGFHFTGVRAGVQCFCCGLILFGASLHKRPLDDHKR LRPDCGFLLGEDVGNVA-KYEVRVRKPPGTL----------------------------- -----------------------------RGDAARYREEEARLKSFKD-------WPFYA -QATAPRELSAAGFV---FTGSRDAAQCFSCGGCLGNWEDGDDPWKEHAKWFPKCEFLQS KKSSEEIAQYIQSYEGFVGVT--------------------GEHFLNSWVKRVVP----- --MVS--------------------------------------AYSS---DSIFANGELR LDSF-K---NWPP-ASPVGAAALAKAGLFY-TGVKDVVQCFSCGVCLENWKEGDDPVEDH TKYSP--NC---QFLQNMKSSAGATPDLQSRDV-IPSPTKSTCESNLADSAAVSSPAP-- ------------------------------------------EMAQGEAQWFQEAKGLSE RLRKAYTSARFCNTSLLEVAPCLATD-QLLGCDLSLASKRIGSHVQEPVVLPEVFATLNS VMCVEGEAGSGKTVLLKRIALLWASGGCPLLNRFQLVFYVSLSSARPDQGLASILCDQLL ETEDSVTEMSLRPIIQQLKNQVLFLLDDFREMCSVPRVIEKLIQRNHSSRTCLLIGVRRS RARAIHRHLHTILEIKAFPFYNSIYILRKLFSHNMIRLRNFMIHFGKNKNLQGIQKTPLF VVAVCAHWFRHPLDQ-SFDDVAVFKSYMECLFLKYKTTADLLRATVSSCGELALKGFFSS CFEFRDDDLVEAGVDQDEDLAMCLMSKSTAQRLRPVYQFLSPAFQEFLAGMRLTELLDSD RQEDRELGLHYLREVNSSLMAVIPYSNFFNYVSCHASTKAGPKVVSHLLRLVDKKESL-- --ENILESDDYLKHRPEISVHME-YFRVLWQLSPKYYF--SQVSEHLLALAIKIAYQSNA LAACSPFILRFLQGRTLTFNMLKSQ------YFFDHPESLLLLRSIQFSIKGRKSS-RLD LSVLETCLDKSQAPTIDQDYASAFEPAKEWEQNLAEKEENVKSFLDMQLNAPPDISTGYW KLSPKPYKIPLLEVHVTDIDAVDQEMLRVLTAVFSASQHIELHLNDSRGFLESVRPALEQ YKASFTKCSISRFELSAADQELLLTLTSLESLEVSGTTWLRDQLFPNLDKFLCLKELSVD LDDKQNVFSVIPEDFVNLHHMEKLLI-RIAAEHGPSKLVRLIQNSPDLQVFHLQCNFFSD FE--SLMTVLASCKKLKEIKFSGRFFKAIPFVIVLPNFTSLKMLNLGHQEFPDRETAEKF AYTLGSLDNLEELILPTGDAVHQVAKLIVQQCEHLRGLRVLSFYQTLNDDSLMEIVRALT SGGGFQKLENLNLSINHKITEEGYRNFFQALDSLPRLQELTISRHFTECIKAQAATVKSL S-QCVSRLPSLIRLNMLSWLLDAEDVTLLTAMKERHPQSKHLTFHWKWILPFSPIIQK-- - >C_intestinalis_ENSCINP00000000466 --------------------MELANNLFSDIETDGMKVNTTSEPSDKRCVYITPGQKERE DYRITTFNKFPSNKPVD-KMKLSSNGFLYTGFKDRVKCFRCGQCVEGLNGTEN-MGLPGW HKPDCEFANGTDTTNVP-LLRHKIQQNLPSLQNAS------------------------- ------------FVQSIPNQDQTTLSAGELLKFGNIDQTTNQVVTPRN-------LP--- ---VQQSSNQFGQMYQTATIHKPHLQVPFSVLQSTRATEPA--PRCAENSQFPC------ ------------------------------------------------------------ -------------------------------------------SNPR---NPHMKSERVR LQTFMNNLGKWSSHGIVTTPEQMADAGLFY-LSDRDRTKCWYCNGGLQNWEPNDDPWYEH AKWFP--EC---EFVLQQKGELYVHRIARQFPN-LNRP--RISNPYQL------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------FGRSNNDVPPPQPQPQSPGPVIIDPQE EQRKLKSK----IDEEMESSAVV---DGAKQMGFEEKEIKRAITK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------NMKENGKSFSTLLSL----------------VDAILA--DSDDDN-- --TSSEEQSEAPTAPETTLTF--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------NT DQ--QST--ASELQRLEMARFCKICRQKEAVVVLLP------------------------ -------------------------------CGHLSCCDTCG------------------ ----------------------------------KKITKCPTCK---LAVTD---KVHSF I-A--------------------------------------------------------- - >C_intestinalis_ENSCINP00000021651 --------------------------MLVDSFCSNLKYQTMFHNIDRVSQHAAAMDYSSK SNRIQSLENFP-SAPVN-PIQLAIHGFYFTGVEDCVVCFSCENSVRNWKLGDKEGDK-KW HKPDCVFFNSLSQTVND-TNISTPNHQ--------------------------------- ---------DMNHFVNTNPTEVVFET--MLLKRLTHKSIKLNIRTFDY-------WPHQL -REVNTAALAKYGFY---YLGISDMVECFCCSNVLGNWNVDDNPKNRHLERFPNCRWVAD VEVHQHPHL--------------------------------------------------- -------------------------------------------LHPH---NAHMRSLEQR RSSFRG---FSPRHHLRATIDEIAEAGFYF-LGPGDLVKCWYCGNKLKNFDVEDEPWMEH AKWFP--QLSIPEFLLQNKGHAFVANIQTSYPR-NVHVVNLPSVESGP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------TFLPSPIQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------NHETLS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------HE KV--DNI--SSGQSNSNSQLCCKVCLNRDATIAFNP------------------------ -------------------------------CGHLCVCQSCS------------------ ----------------------------------PRLNACPICR---RSIQQ---KIRIY F-P--------------------------------------------------------- - >C_intestinalis_ENSCINP00000011648 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MAAAGLFY-IGQTDRVKCWYCNGGLQNWLPNDDPWFEH AKWFP--TC---EYVLQQRGPEYVHNVCMQFPN-LRRPDLPLRNLPSV------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VSGPSHQTPGGGLLYHQSPQIIDPRE ETRRRKAK----IDREMIASPLV---NQARQLGFSNNQIRSAFTK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SFEVSDKTCENMDEL----------------IDIISN--LPNDDH-- --DQARGSNEQTTSYQYS------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ST AT--LSR--AEEIRAIEESKICKVCRNANACIVLLP------------------------ -------------------------------CGHLSVCQGCS------------------ ----------------------------------VNIERCPICR---TFTRE---KLLTY L-V--------------------------------------------------------- - >A_carolinensis_ENSACAP00000005440 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QPE---YPDLAMERDR LRTY-D---SWPS-DAQVSPEELAGAGFFY-TGDRDYVLCFYCDGALRNWERGDDPWMEH ARWFP--RC---EFLLQSRGRDFINSIQDSYFS-TLVS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------KVVLKDPFPKTGMTEKQNPCG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------NVEIIP--CSREVE-- --TEQPNQPDST------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----LST--EEKLRQLQEERMCKVCMDKDVSIVLVP------------------------ -------------------------------CGHLVVCSECA------------------ ----------------------------------PNL----------------------- ------------------------------------------------------------ - >A_carolinensis_ENSACAP00000009897 ------------------------------------------------------------ -------------STWA-PLEMAAAGFYHTGTKTAIQCFCCGLVLLARSIKRSPYVEHKK YWSQCAFILGKEVGNIP-KYEIRVLYPR-------------------------------- ----------------------------RRYSGVTYKHLESRLQSFAD-------WPSYA -REAQPDLLAKAGFF---FTGIKDTVQCFACSGCLGNWEDGDDPWKEHAKWFPECEFLQK EKTRDEIKEYIQNYCAFVGLT--------------------VSFFAFTLLIYLVP----- --KGD--------------------------------------LELA---INIYEDEGCR LDSF-Q---TWPA-EARVDATSLAKAGFFY-TGKMDIVQCFSCAGCLAEWKGDDDPWEGH AKAFPQEEC---DFMQNLAK---ITSMPFQDMK-LCQHSSSFHHISHIFLLSLLTDVA-- ---------------------------------------------------FEEHKLLQE QLRRAYDDIHFRKMFPFGDSAHFAIDLKTLFGDLAIVSKNISNLPLQQLTLPEVLENFQF ITVVEGEAGSGKTALLRKIAILWASGCCPILSRYKLVFYLSLNSQNRDLSLVDIICNEVV GLRGVLTQEFLETLCKHLKNEILFLLDDYDEMNAVPYDIEDLIQKNYLNKHCLVIAVRTN RIGKIRQYAKTILGITDFPMTSTFYLLRKLFSHNTALVEDFFIQLRVEEAMHSMFKTPLF VVALGTYWTQNPNGS-KFLDLVILKAYMLYTSLKYPQACDRMKATVSACGELALRGLFTS LFEFSEEDLSEVGVSGDDALWFGLLSKFTAQRLWPIYKFFHLSFQEYFAGLRMNELLSSD VQEDVDRGLQYLQQINTFVKISGRYQYILRYACVE-ASKAVPQIVTHLLSLPSCEKSF-- --ESQIKNDLYLQQTPELKLRQQELLSVTLTLFPEVYL--STFSDFVLELVTELAYQSNM TPACAPIISQFLAGKEFSLDHFSSKGGFIRRFFLDYPDTLFLPSRFVMKTIGKEEN--LD MSVEETVYSNLGVPVVDQEYASGFRLFSDVSKQIKEDEDNINKFRTYFPRRFPNSRIVPF LCKRGQEKIPHLQFSAKCINAFQTHDLENLAVLFSVFSHIDLKLQNCKGLLENIKPAIEQ NLEYFKVCSIHNTALNLVEENLLLSMSSLESLEITGKASIPESLFLNLDKYTFLKELSVD LPNCQNLFDIIPEGFKNLHDMEKFIICNIQFGSSSPRLAEFIRNFKKLSVFHLKHCSFSD LG--SLMDAMSSCKMLTELEIIELPFTDEDHSAALPNFAALKILNLNGLNFTSKEIGIAL GEALAPLENLEELSLPVGNGMSHAAKLIIQQCSHFPNLRKLEFNQYLSGEGLLEIAKVAT D-GGFQKLEVLTLLVNHSITEEFWRRFFESLPQLPKLHDANFGRIFTHPIKCQAATVKSF V-QCVSRQQNLKVINMTGWLFDEKDLQMFDIMKEQHPQSKNLSLFWKWMLPVSPIINK-- - >B_taurus_ENSBTAP00000046955 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------RC---EFLIRMKGQEFVSEIQARYPH-LLEQ--LLSTANTS------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GDENADPP- -IVHFGPGESSSDDAVMMNTPVV---KAALEMGFSRSLVKRTVQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILTTGENYKTVNDI----------------VSALLN--AEDEKREE EKEEEKERQTEETAS--DDLSLLRRNRMALFQQLTC-V--LPILDNLLKANVINKQEHDI IKQKTQIPLQARELIDTVLVKGNSA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ASIFKNCLKEIDPTLYKNLFVEKNMKYIPT-DV SG--LSL--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCQECA------------------ ----------------------------------PSLRKCPICR---GIIKG---TVRTF L-S--------------------------------------------------------- - >X_tropicalis_ENSXETP00000016315 ------------------------------------------------------------ -----------KHFPYQTSDKLAWAGFFYVGPGDRVRCFSCGGEVDNWEPGDVPLTRHQL FFPHCSYVQGLSIRHSY------------------------------------------- ------------FMEEGVGPGFLDTNILGKE--GDMSDEYSRIQSYQA-------VKEHF -PNQTPIKLAWAGFY---YVGPKEKVRCFSCGGEMDEWWSREDPLTEHHRRFPQCHFILG RKEGNPPGKG-------------------------------------------------- -------------------------------------------SLPS---PRIFLCPRKC LEAQ-L---DFPCLLHHQTPIKLAWAGFYY-VGPKDKVQCFSCGGEMDKWWSREDPLTEH HRRFP--QC---HFILGRKA---VSNDPYTM----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TEMLKGLNNQQSQPT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ - >A_gambiae_AGAP007292-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MESHDNTERQERTGLCNELNYNQEINRLRTYFPL------WTVP- --YIYPEELARWGFF---YTGYRDCVRCYFCHIELGGWDEHDVVIEEHLKWSPDCRLMTK RPTDNVPVDANFLDQL-------------------------DTAGTGIPIQLGTA----- --ASRYNGPCNRYQPTSSHDNPEWHRQTVLNVSAPV-------YEPT---IPHYEIGDNR LASF-Q---EWPK-CMKQTPEQMADAGFFY-TGKSDVVICFCCGGQLRDWLPEYNPWVEH AKNFS--GC---PYLKLVKTPGFIAECQAKWYT-NDVLIGRPEYPGHD------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----VTK--RKEQHEVADENCCKICYTRPFDTVFIP------------------------ -------------------------------CGHVVACGRCA------------------ ----------------------------------ASTLNCPVCN---KWYTS---VQRIL F-T--------------------------------------------------------- - >X_tropicalis_ENSXETP00000034890 ------------------------------------------------------------ -----------KHFPYMKEWDLAQAGFYYVGPGDRVRCISCNAELEKWEKWDEPLTRHQH SFPDCAYVQEQRAQTTG-TQDQSQVCPM-------------------------------- ---------PIKEGESGIPARYSGSHNPGEKPLGDMNDEYSRLETYRG-------HSQYF -PMANQRRLAQAGFS---YVGPGDQVRCFSCGGELEKWERWDVPLTRHQHSFPHCHYIYG RKTGY-------IGIPLLRPL--------------------------------------- -------------------------------------------GEVS---ETQLLYGRRS WTGF-S---GHQHPREDQTPIKLAWAGFYY-VGPKDKVRCFSCGGEMDEWWSREDPLTEH HRKFP--QC---HFILGRKA---VSNDPYTM----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TEMLKGLNNQQSQPT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ - >O_cuniculus_ENSOCUP00000002871 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QQDKMRCFFCYGGLQS-ERGDD-WTEH AKWFP--RC---QFLLRSKGRDFVHSIQESGSQ-LLGP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------WDLWEEPEDTAPASPSGPVHQ------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------APELLT--PRTEPW-- --LESAREPGGTRAR--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LRVQRVLGPP GAGAVAM--EEQLRRLQEERTCKVCLDQAVSVVFVP------------------------ -------------------------------CGHL-VCTQCA------------------ ----------------------------------PNLHLCPICR---APVRS---CVRTF L-S--------------------------------------------------------- - >G_gorilla_ENSGGOP00000005705 -----------------------------MNIVEN-SIFLSNLMKSAN-TFELKYDLSCE LYRMSTYSTFPAGVPVS-ERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPIEKHKK LYPSCRFVQSLNSVNNLEATSQPTFPSSVTNS---------------THS-LLPGTENSG YFSGSXSN-SPSNPVNSRANQDFSALM-RSSYHCAMNNENARLLTFQT-------WPLT- --FLSPTDLAKAGFY---YIGPGDRVACFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXX----------------------------------------XX------------- -------------------------------------------XXXX---XXXXXXXXXX XXXX-X---XXXX-XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXX--XC---EYLIRIKGQEFIRQVQASYPH-LLEQ--XXXXXXXX------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------XXXXXXXX- -XIHFEPGEDHSEDAIMMNTPVV---NAAVEMGFSRSLVKQTVQR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KILATGENYRLVNDL----------------VLDLLN--AEDEIR-- --EEERERAXXXXXX--XXXXXXXXXXXXXXXXXXX-X--XXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXX----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XX--LPV--EEQLRRLQEERTCKVCMDKEVSIVFIP------------------------ -------------------------------CGHLVVCKDCA------------------ ----------------------------------PSLRKCPICR---STIKG---TVRTF L-S--------------------------------------------------------- - >C_intestinalis_ENSCINP00000000047 ------------------------------------------------------------ ------------------------------------------------------MQTARV VEPT-------------------------------------------------------- -------K-PASQYQRVELATIASPYHEKLVRSLDLRKESDRFKTYEN-------WPAQN -RTVYASDLARSGFF---YLGNLDRVQCFSCGGVLRNWNYGDNITAEHRRHFPHCRMVQG TETRN-VASAVPPPQPIPPRG--------------------PGIQEPPDPNETEM----- --RDLMNMFRC--------------------------------QYPV---SPYMRNEESR FETFDH---RWPASNVRASPRQIAKAGFFF-LGDRDRVKCWYCNGGLQN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ - >X_tropicalis_ENSXETP00000016312 ------------------------------------------YSGSQNPGEKPLGDMNDE YSRLETYRGHSQYFPMANQRKLAQAGFSYVGPGDRVRCISCGGELEKWERWDVPLTRHQH SFPHCPYMQKLRDEGDG-KENQSKVCAG-------------------------------- ---------PIKEGESGTTVPLSSSSNLEKKPCGYMSDEYSRLESYRGHGQHFNYWNQQR LAKQTSDELAWAGFF---YVGPGDRVRCFSCGGEVDNWEPGDVPLTGHQLFFPHCSYVQG LSIRHSYFMEEGVGPGFL------------------------------------------ --------------------------------------------------DTNILGN--R IQSY-Q---AVKEHFPNQTPIKLAWAGFYY-VGPKDKVQCFSCGGEMDKWWSREDPLTEH HRRFP--QC---HFILGRKA---VSNDPYTM----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TEMLKGLNNQQSQPT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ - >C_intestinalis_ENSCINP00000002312 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MFRC----------------------------- ------------------------------------------------------------ -------------------------------------------QYPV---SPYMRNEESR FETFDH---RWPASNVRASPRQIAIAGFFF-LGDRDRVKCWYCNGGLQNWDPDDEPWTEH AKWFP--TN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------IINR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RLTSGGNLYTSVADL----------------VDDITA--NENEPN-- --SDDDDETNTSQPSQTTTVKT-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------TERKCKICLDKVADIVFVP------------------------ -------------------------------CGHLCTCTECA------------------ ----------------------------------KALRKCPICR---SKFER---GIKTY M-S--------------------------------------------------------- - >O_cuniculus_ENSOCUP00000014265 ----------------MHKTASQRVVPGTSYRIKSMMEDSTISSNTNDQNQKMKYDFSYK I-RVPTYSGLPIRVPLS-EWSLAPAGLYYIGM-NKVKCFCCDLMLDNWKQEYNLIEKHKQ LYPSCSFSQNLISV-SLESPLRSSFAHP-----------------------LFPTQGPCV SFSGSYPS-LSANPPNLTSV-DFSPLR--TSLGYSMSTEEAR---FYY-------KPFS- --FLLPSEFARAGFS---NVAPGDAVAGFACDRKQSNWKKDDAML--EWRHVPN-PFLEI LR---------------------------------------------------------- -------------------------------------------FSIS---NWSMQAH-AQ MSTN-M---YWPS-SDPVCPEQLATVDFYY-VALSDDIKCFCCDGALR-FECGDDA-VEH AKLFA--RC---EFLMGVKG-EFVDEIQDRFPH-LHQQ---LLTSDPL------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GEENADPP- -IFHFGPG-SSSDDKGMMNTLVV---KSVLEMSFNISFAKETVHS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KTLPTRENHKTVNDI----------------ASTLLN--AEDEKR-- --GEERQAEE-------------RANSMTLFQQLVC-V--LPILNHLLKVNVIN-KENDI IRQK-QKPLQAIELVDTVLLKGIVA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ANTFKNCLKDIDSMLYKN-FEKKNTKYFPTEDI SC--PSL--GDQLRRLQ-EVTFKMCIDKEVSILFIP------------------------ -------------------------------SSNLVVCQACA------------------ ----------------------------------HSLRKYPICR---GIIKG---TVCTF L-SK-------------------------------------------------------- - >X_tropicalis_ENSXETP00000057704 ------------------------------------------------------------ ------------------QNKLANAGFYYVGPEDRVRCFSCGGQFEMWEEWDFPLTRHQQ TFPECPYLQELKAKGEW-KDCHYEPGLGSNILMEK------------PLG-DLSDERRR- LETFRGHS-GLFPYNRVKFLAIQSPNILGKKSHYDMTNMYSRADTYRG-------HHKHF LPYMKEWDLAQAGFY---YVGPGDRVRCISCGGELEKWERWDVPLTRHQHSFPHCPYMQK LRDEGDG----------------------------------------------------- -------------------------------------------GTVS---ILYIGTNRAW LRQVST---MWGP-RTGSRENKLANAGFYY-VGPRDRVRCFSCGGQLEMWEEWDFPLTRH QQTFP--EC---PYLQELKAKGEWQLIMMAQAG-F------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ - >A_gambiae_AGAP012677-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MPQTPERMADAGFFY-TGKSDVVACFYCGGNLRDWLAEDDPWVEH VRNFS--EC---PYVKLVKTPEFIAECRGEKVT-NSALTAGPEHSGHG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -N--VSK--DKEQDEVSDEKCCKICFTRPFDTVFMP------------------------ -------------------------------CGHVVACGRCA------------------ ----------------------------------ATTTKCPMCN---EPYTS---VQRIY F-S--------------------------------------------------------- -