10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0085443 MAPTTSPPP-----KLAKFKSSSLDHEIYTA-----------------------NRRGTIATASSDWKALRGGVGGG-----AGGPGSVPNPSNGRSLHAGGPMTRAASTSSLASSTRT- A_aegypti_AAEL001515-PA MEMTSP--------------------------------------------------------------------------------------------------TLANNFANVWTNRRS- A_gambiae_AGAP011552-PA MSSTAGAFHQQHQPQQQ-------------------------------------SPRSPIVAAAVAAAAAIGAVSGG-----------------------------SAGGVVGWTNKRS- A_aegypti_AAEL001521-PA MLSAEAPVSHNHHLLPDRLSAPA-------------------------------LARRKFSFPANLHSTVLHGDPPGSINSGSLQPSSTASFARRRLSNVSDVVTRK------LSSTIG- D_melanogaster_FBpp0087182 MPGTSYPTNNDNFSNGFPMATTQSERL-LQA-----------------------QNRRKFSFPATLHSASLLEVGGG--------PKET---TRRRLSNVSDAVTRK------LSYTIG- T_nigroviridis_ENSTNIP00000005841 ME----------------------------------------------------MLRRSSMFAA---EV--------------------------------------------------- O_anatinus_ENSOANP00000008963 ME----------------------------------------------------VLRRSSVFAAEVMEV--------------------------------------------------- G_gallus_ENSGALP00000009257 ME----------------------------------------------------VLRRSSVFAAEVMEV--------------------------------------------------- G_aculeatus_ENSGACP00000006084 MD----------------------------------------------------MLRRSSVFAA---EV--------------------------------------------------- T_rubripes_ENSTRUP00000030263 ME----------------------------------------------------MLRRSSVFAA---EV--------------------------------------------------- T_guttata_ENSTGUP00000006267 ME----------------------------------------------------VLRRSSVFAAEVMEV--------------------------------------------------- T_nigroviridis_ENSTNIP00000018321 ME----------------------------------------------------VLRRSSVFAAEVLDV--------------------------------------------------- D_rerio_ENSDARP00000068408 ME----------------------------------------------------MLRRSSVFAAEVMEV--------------------------------------------------- M_domestica_ENSMODP00000020066 ME----------------------------------------------------VLRRSSVFAAEVMEV--------------------------------------------------- A_carolinensis_ENSACAP00000000851 MD----------------------------------------------------VLRRSSVFAAEVMEV--------------------------------------------------- O_latipes_ENSORLP00000002641 LE----------------------------------------------------SMRACGVARVNPAQA--------------------------------------------------- G_aculeatus_ENSGACP00000018053 ME----------------------------------------------------VLRRPSVMAAEVLDV--------------------------------------------------- T_rubripes_ENSTRUP00000018728 ME----------------------------------------------------VLRRSSVFAAEVLDV--------------------------------------------------- H_sapiens_ENSP00000314132 ME----------------------------------------------------VLRRSSVFAAEIMDA--------------------------------------------------- G_gorilla_ENSGGOP00000015296 ME----------------------------------------------------VLRRSSVFAAEIMDA--------------------------------------------------- M_mulatta_ENSMMUP00000007481 ME----------------------------------------------------VLRRSSVFAAEIMDA--------------------------------------------------- P_pygmaeus_ENSPPYP00000014939 ME----------------------------------------------------VLRRSSVFAAEIMDA--------------------------------------------------- M_musculus_ENSMUSP00000027499 ME----------------------------------------------------VLRRSSVFAAEIMDA--------------------------------------------------- R_norvegicus_ENSRNOP00000024693 ME----------------------------------------------------VLRRSSVFAAEIMDA--------------------------------------------------- O_latipes_ENSORLP00000020538 MD----------------------------------------------------VLRRSSVFAAEVLDV--------------------------------------------------- B_taurus_ENSBTAP00000011478 ME----------------------------------------------------VLRRSSVFAAEIMDA--------------------------------------------------- D_rerio_ENSDARP00000090569 MN----------------------------------------------------VFARSSVLAAEMMDV--------------------------------------------------- C_intestinalis_ENSCINP00000019812 MTSYTSDVNHNSIYETERKNKRTLLADNINS-----------------------IMRDSVTFVTSSIADLTSSCVSLGDD---------------------------------------- C_intestinalis_ENSCINP00000016140 MTSHESENASGFLKPEMESQRRHSWDGRFSTNKIDLGGESTVCRNDSKGRRRRELRRSHVVTEAPDVTLFEEQDQNNASTIPTKDDPTPVASENKNTNNRPWGLRRRITKTENHCEKIED X_tropicalis_ENSXETP00000053903 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000012873 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000021005 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000002093 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032199 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024313 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000017662 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010122 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000096467 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006866 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008572 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000014770 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000010059 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010478 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000365230 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000012163 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022903 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000003768 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108371 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000007865 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000040259 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008651 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000381185 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000017121 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000010339 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000778 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000020984 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000002788 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000086454 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002775 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017513 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013488 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000038537 MTDC-------------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000025701 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000014135 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095258 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017850 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005643 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018978 MADGGREKQDDGDREPRGAEGGED------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000102 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013781 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007577 ------------------------------------------------------------------------------------------------------------------------ 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0085443 ------------------------------------------------------------------------------------MTNYQEYKMDIINQGKCLCGQYIRARLRRAGVLNRK A_aegypti_AAEL001515-PA ------------------------------------------------------------------------------------PIHHLTTTQDVINQGKCLCGEYIRARLRRSGLLNRK A_gambiae_AGAP011552-PA ------------------------------------------------------------------------------------PIHHLTTSQDVINQGKCLCGEYIRARLKRSGLLNRK A_aegypti_AAEL001521-PA ------------------------------------------------------------------------------------WKQPVLPSQDIITQGKCLCGQYIRCRLKKSGVFNRK D_melanogaster_FBpp0087182 ------------------------------------------------------------------------------------WKAAQIPAQDIISQGRCLCGHYIKRRLRRSGLFNKK T_nigroviridis_ENSTNIP00000005841 ------------------------------------------------------------------------------------FDRS-PTDKELVSQAKALCRDYIHSRLNRAGIGWSK O_anatinus_ENSOANP00000008963 ------------------------------------------------------------------------------------FDRS-PTDKELVSQAKALCREYIHSRLIRASLVWSK G_gallus_ENSGALP00000009257 ------------------------------------------------------------------------------------FDRS-PTDKELVSQAKALCRDYINSRLIRAGVSWSK G_aculeatus_ENSGACP00000006084 ------------------------------------------------------------------------------------FDRS-PTDKELVSQAKALCRDYIHSRLNRAGMGWSK T_rubripes_ENSTRUP00000030263 ------------------------------------------------------------------------------------FDRS-PTDKELVSQAKALCRDYIHSRLNRAGVGWSK T_guttata_ENSTGUP00000006267 ------------------------------------------------------------------------------------FDRS-PTDKELVSQAKALCRDYINSRLIQAGVSWSK T_nigroviridis_ENSTNIP00000018321 ------------------------------------------------------------------------------------FDRS-LTEKELVSHSKALCRDYILSRLTQSGLGWSK D_rerio_ENSDARP00000068408 ------------------------------------------------------------------------------------FDRS-PTDKELVSQSKVLCRDYIHSRLHRAGIGWSK M_domestica_ENSMODP00000020066 ------------------------------------------------------------------------------------FDRS-PTDKELVSQAKALGREYIHSRLIRAGLVWSK A_carolinensis_ENSACAP00000000851 ------------------------------------------------------------------------------------FDRT-PTDKELVSQAKVLCRDFIHSRLIRAGIGWNK O_latipes_ENSORLP00000002641 ------------------------------------------------------------------------------------FSRSAPTDKELVSQAKALCREYIHSRLNRAGIGWSK G_aculeatus_ENSGACP00000018053 ------------------------------------------------------------------------------------FDRS-LTEKELVSQSKALCRDYILSRLHQNGQGWSK T_rubripes_ENSTRUP00000018728 ------------------------------------------------------------------------------------FDRS-LTEKELVSHSKALCRDYILSRLNQNGLGCSK H_sapiens_ENSP00000314132 ------------------------------------------------------------------------------------FDRS-PTDKELVAQAKALGREYVHARLLRAGLSWSA G_gorilla_ENSGGOP00000015296 ------------------------------------------------------------------------------------FDRS-PTDKELVAQAKALGREYVHARLLRAGLSWSA M_mulatta_ENSMMUP00000007481 ------------------------------------------------------------------------------------FDRS-PTDKELVAQAKALGREYVHARLLRAGLSWSA P_pygmaeus_ENSPPYP00000014939 ------------------------------------------------------------------------------------FDRS-PTDKELVAQAKALGREYVHARLLRAGLSWSA M_musculus_ENSMUSP00000027499 ------------------------------------------------------------------------------------FDRS-PTDKELVAQAKALGREYVHARLLRAGLSWSA R_norvegicus_ENSRNOP00000024693 ------------------------------------------------------------------------------------FDRS-PTDKELVAQAKALGREYVHARLLRAGLSWSA O_latipes_ENSORLP00000020538 ------------------------------------------------------------------------------------FERS-LSEKELVTQSKALCRDYILSRLHQNGMGWSK B_taurus_ENSBTAP00000011478 ------------------------------------------------------------------------------------FDRS-PTDKELVAQAKALGREFVHARLLRAGLSWSA D_rerio_ENSDARP00000090569 ------------------------------------------------------------------------------------FDRT-HTEKELVFQSKELCRDFIHSRITREGLSWSK C_intestinalis_ENSCINP00000019812 ------------------------------------------------------------------------------------SVFNSTSYEEDVRLTTGICRDYICYRLKRDGFGERV C_intestinalis_ENSCINP00000016140 STPANQTGTPKRRSGIASFATGSSPRNLWQPQKPSVRFTDVNDSNINAATPPDMSSRSFRNRRATVHYSSTGRPSVMERRHPARIALE-AKEGKALEQTKDICKDYIVHRLQQRKLANRV X_tropicalis_ENSXETP00000053903 ----------------------------------------------------------------------------------------------MEGSSRDLVEKFVCKKLSQKGACGEF T_rubripes_ENSTRUP00000012873 ------------------------------------------------------------------------------------------QVGMERECNRDIVENYICHKLSKRGFAWSF O_latipes_ENSORLP00000021005 ---------------------------------------------------------------------------------------------MANVSNRSIVEKYICHKLSKRGYVCGL T_guttata_ENSTGUP00000002093 ----------------------------------------------------------------------------------------MAHPGRRGYDNREIVLKYIHYKLSQRGYDWAA T_rubripes_ENSTRUP00000032199 ----------------------------------------------------------------------------------------------MSYNNRELVEHFLRYKLSQRNYPTSL M_domestica_ENSMODP00000024313 ----------------------------------------------------------------------------------------------MSHSNRELVIDFLSYKLSQKGYNWSQ G_aculeatus_ENSGACP00000017662 ---------------------------------------------------------------------------------------------MSNECNRHIVEKYICHKLSKRGYAFGF T_nigroviridis_ENSTNIP00000010122 ----------------------------------------------------------------------------------------------MSYDNRELVEYFLGYKLAQRNYPSSL D_rerio_ENSDARP00000096467 ------------------------------------------------------------------------------------------MANEISYDNRNIVEKYLKHKLSKRGYVWKC T_guttata_ENSTGUP00000006866 ----------------------------------------------------------------------------------------------MYSSNRELVIDFVSYKLSQKGYSWSQ B_taurus_ENSBTAP00000008572 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ E_caballus_ENSECAP00000014770 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYNWSQ G_gallus_ENSGALP00000010059 ----------------------------------------------------------------------------------------------MSSSNRELVIDFVSYKLSQRGHCWSE C_familiaris_ENSCAFP00000010478 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ H_sapiens_ENSP00000365230 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ P_pygmaeus_ENSPPYP00000012163 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ P_troglodytes_ENSPTRP00000022903 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ R_norvegicus_ENSRNOP00000003768 ----------------------------------------------------------------------------------------MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDT M_musculus_ENSMUSP00000108371 ----------------------------------------------------------------------------------------MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDA M_mulatta_ENSMMUP00000007865 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ R_norvegicus_ENSRNOP00000040259 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ M_mulatta_ENSMMUP00000008651 ----------------------------------------------------------------------------------------MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDA H_sapiens_ENSP00000381185 ----------------------------------------------------------------------------------------MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDA P_troglodytes_ENSPTRP00000017121 ----------------------------------------------------------------------------------------MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDA P_pygmaeus_ENSPPYP00000010339 ----------------------------------------------------------------------------------------MAHAGTTGYDNREIVDEXIHYKLSQRGYEWDA G_gorilla_ENSGGOP00000000778 ----------------------------------------------------------------------------------------MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDA G_gallus_ENSGALP00000020984 ----------------------------------------------------------------------------------------MAHPGRRGYDNREIVLKYIHYKLSQRGYDWAA T_nigroviridis_ENSTNIP00000002788 ---------------------------------------------------------------------------------------------MAREYNRDIVEKYIFHKLSKRGFVWRF M_musculus_ENSMUSP00000086454 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ O_cuniculus_ENSOCUP00000002775 ----------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKGYSWSQ O_latipes_ENSORLP00000017513 ------------------------------------------------------------------------------------------QAHTMSHCNRELVRFYLAYKMSCRDYPVSL G_aculeatus_ENSGACP00000013488 ----------------------------------------------------------------------------------------------MANINRELVEFFLSYKLSQKNHPTSL R_norvegicus_ENSRNOP00000038537 ----------------------------------------------------------------------------------------------EFMYIHSLAENYLQYVLQVPAFE--- B_taurus_ENSBTAP00000025701 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000014135 ----------------------------------------------------------------------------------------------MS-QNRELVIFYIKYKLSQRNYPFNH D_rerio_ENSDARP00000095258 ----------------------------------------------------------------------------------------------MSYYNRELVVFFIKYKLSQRNYPCNH E_caballus_ENSECAP00000017850 ----------------------------------------------------------------------------------------MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDA G_aculeatus_ENSGACP00000005643 ----------------------------------------------------------------------------------------------MS-QNRELVVFYINYKLSQRNLPLNH G_aculeatus_ENSGACP00000018978 -----------------------------------------------------------------------------------------VVDDPIMEQGAVVLRGYVVSRINAEDPSRHV C_familiaris_ENSCAFP00000000102 ----------------------------------------------------------------------------------------MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDA T_nigroviridis_ENSTNIP00000013781 ----------------------------------------------------------------------------------------------MSHTNRELVEFYLNYKLSHSNFLTSL T_nigroviridis_ENSTNIP00000007577 -------------------------------------------------------------------------------RSHPGAKSKGASTQRMS-LNRELVIFYIKYKLSQRNYPLSH 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0085443 V-T-Q------RLRNILD--------PGSS-------------------------------------HVVYEVFPALNSMGEELERMHPRVYTNISRQLSRAPFGELEDSDMAPMLLNLV A_aegypti_AAEL001515-PA I-L-Q------RLRSTME--------VPNC-------------------------------------VVVRETSPILNGMGEELERMHPRLYTNVSRQISVEPWGELTEPDSVCYLLHIV A_gambiae_AGAP011552-PA I-L-Q------RLRNSMEHCMAGSGGLGGG-------------------------------------AVVREALPILNGMGEELERMHPRLYSNVSRQISNEPWGELTEPDTVGYLLHVV A_aegypti_AAEL001521-PA LGL-Q------RIRSIVG--------TPTI-------------------------------------HVVREVFPALLSVGEELERMYPRVYNGVARQLSRIGRGELKTPETAPVLLSAI D_melanogaster_FBpp0087182 LGL-Q------RIRSILG--------STSM-------------------------------------GIVRDVFPAVQVLGDELERMHPRIYNGVARQICRNPGGEFHTPDAVSLLLGAV T_nigroviridis_ENSTNIP00000005841 AEN---------------------GPPASG-------------------------------------GTLGEASAVLLWLGDELEHLRPNVYCNVARQLNITVASE----SIMSDAFLAV O_anatinus_ENSOANP00000008963 PDY---------------------NVPSPG-------------------------------------GKLAEVSTILLRLGDELEYIRPNVYRNIARQLNISLHSE----TVVTDAFLAV G_gallus_ENSGALP00000009257 PEH---------------------NTPVPG-------------------------------------GKLAEVSAILLCLGDELEYIRPNVYRNIARQLNISLHSE----TVVTDAFLAV G_aculeatus_ENSGACP00000006084 PES---------------------GRAAPG-------------------------------------GGLGDVSSALLWLGDELEYLRPNVYRNVARQLNITVASE----SIVSDAFLAV T_rubripes_ENSTRUP00000030263 ADH---------------------GLAASG-------------------------------------GTLGEVSSVLMWLGAELEYLRPNVYCNVARQLNITVASE----SIMSDAFLAV T_guttata_ENSTGUP00000006267 PEY---------------------NAPVPG-------------------------------------GKLAEVSTILLRLGDELEYIRPNVYRNIARQLNISLHSE----TVVSDAFLAV T_nigroviridis_ENSTNIP00000018321 SEL---------------------NLSPSS-------------------------------------TALADASMVLLCLGDELESMQPSLYRNVARQLNISVAME----NMVSDAFIAV D_rerio_ENSDARP00000068408 PEH---------------------G---SG-------------------------------------GTLAEVSSVLLWLGDELEYLRPNVYRNVARQLNITIASE----NIVSDAFLAV M_domestica_ENSMODP00000020066 PEA---------------------KTPTPG-------------------------------------GKLAEVASILLRLGDELEYIRPNVYRNIARQLNISLQSE----SVVTDAFLAV A_carolinensis_ENSACAP00000000851 PEH---------------------SVPVPG-------------------------------------GKLAEVSNILLRLGDELEYIRPNLYRNVARQLNISLHSE----TVVTDAFLAV O_latipes_ENSORLP00000002641 PEH---------------------AQAGAG-------------------------------------GALGEVSSVLLWLGEELEYLRPNVYRNVARQLNITVASE----SIVSDAFLAV G_aculeatus_ENSGACP00000018053 TEL---------------------HLSPSS-------------------------------------AALAEVSLVLLCLGDELESIRPSLYRNVARQLNISVAME----NMVSDAFIGV T_rubripes_ENSTRUP00000018728 AEL---------------------NLSPSS-------------------------------------AALADASMVLLCLGDELESMQPSLYRNVARQLNISVAME----NMVSDAFIGV H_sapiens_ENSP00000314132 PER---------------------AAPVP--------------------------------------GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSE----PVVTDAFLAV G_gorilla_ENSGGOP00000015296 PER---------------------AAPVP--------------------------------------GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSE----PVVTDAFLAV M_mulatta_ENSMMUP00000007481 PER---------------------AAPVP--------------------------------------GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSE----PVVTDAFLAV P_pygmaeus_ENSPPYP00000014939 PER---------------------AAPVP--------------------------------------GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSE----PVVTDAFLAV M_musculus_ENSMUSP00000027499 PER---------------------ASPAPG-------------------------------------GRLAEVCTVLLRLGDELEQIRPSVYRNVARQLHIPLQSE----PVVTDAFLAV R_norvegicus_ENSRNOP00000024693 PER---------------------ASPAPG-------------------------------------GRLAEVCTVLLRLGDELEQIRPSVYRNVARQLHIPLQSE----PVVTDAFLAV O_latipes_ENSORLP00000020538 AEI---------------------NFSPSN-------------------------------------AALSEVTMVLLCLGDELECIQPGLYRNVARQLNISVAME----NVVSDAFLGV B_taurus_ENSBTAP00000011478 PER---------------------AAPVPG-------------------------------------GRLAEVCAVLLRLADELELIRPSVYRNVARQLNLSLQSE----TVVTDAFLAV D_rerio_ENSDARP00000090569 VEL---------------------DLPEPR-------------------------------------GVLVDVSVVLLKLGDELECMRPYVYRNIAKQLNISVSVE----AVVSDAFLSV C_intestinalis_ENSCINP00000019812 TVT-EHAP-----------------------------------------------------------AHNHNLSNKILNLGSGFERMFPKSFRQISRQIGYVFSSE----ATVRRLYFRM C_intestinalis_ENSCINP00000016140 KVT-R------Q-----------------Q-------------------------------------SASRALSRDVIFIASELERMQKHLYSDVSKQIGITLRSE----DVLRKVFFEL X_tropicalis_ENSXETP00000053903 SSN-SQPKGVSNGSSEGPGATQG--------------------------------------------IVGEEVLQALLDASEEFELRYQRAFSDLTAQLHLTQ-------DTAQQSFQQV T_rubripes_ENSTRUP00000012873 EDV-QDENAANNGSVVAPAPTLVRRCHEAGTGPDRDRGSISHPCKEPPAS-----------------DQHAAIHRVLREAGDELERLYQPDFTEMSRQLYLSS-------TTAQRRFAEV O_latipes_ENSORLP00000021005 NGG-QRENAANNGSVGDHSPTPA--------------------------------------------DPLADIHRVLREAGDELERLYQRDFTEMSRQLYLTS-------TTAKTRFAEV T_guttata_ENSTGUP00000002093 GED-RASLPPDHSASAAAAIAAAAIAAAGTS--DHTGLVSPHPEPPGSAT--ASHTPPAEGLR----PAPQAVHLVLRQAGDEFSRRYQRDFSQMSGQLHLTP-------FTARSRFVAV T_rubripes_ENSTRUP00000032199 LRP-EDTDGRTEGEKRSP-GASNGLLVRSRNR----GGASPSA---------------G--------AGIEAVNAALRDSAEEFEKLFAQAFSDLSSQLDITP-------DTAYQSFKNV M_domestica_ENSMODP00000024313 FED----ENRTEVLEGA----------EIPSTV---NGSPSWHPADSRA--VSGATGHSSSLDAHETIPVAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQV G_aculeatus_ENSGACP00000017662 DDV-GEEDAASNGSMVVPPPTAVRRCREAGP----DGESFPRLCKRLPQSD----------------PTAAATHRVLREAGDELERLYQPDFTEMSRQLYLTS-------TTAQRRFAEV T_nigroviridis_ENSTNIP00000010122 LRP-QEPDGWTEGDKKSP-AAVNGLLIRNRSR----SGASAST---------------G--------AGVEAVHAALRDSAEEFEKLFAQAFSDLSSQLVITP-------DTAYQSFKNV D_rerio_ENSDARP00000096467 QSS-AEEDDTFNKAVEESSPNSDRRLQAPSAGGGNNSECLIARVTRS--------------------DPHLRLYRVLRDAGDEIERIYQREFEEMSQQMVFNP-------NSAQRSFLTV T_guttata_ENSTGUP00000006866 LEE-E-DENRTDFAGE---------EDEMDGVL---NGSPSWHAATSHI--VNGATVHQNSLEVHEIRRAADVRQALREAGDEFELRYRRAFSDLTSQLHITP-------STAYQSFEQV B_taurus_ENSBTAP00000008572 FSD-V-EENRTEAPEGTE------SDMETPSAI---NGNASWHLADSPA--VNGATGHSRSSDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQV E_caballus_ENSECAP00000014770 FSD-V-EENRTEAPEGTE------SEMETPSAI---NGNPSWHLADSPT--GNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQV G_gallus_ENSGALP00000010059 LEE-E-DENRTDTAAE----------AEMDSVL---NGSPSWHPPAGHV--VNGATVHRSSLEVHEIVRASDVRQALRDAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQV C_familiaris_ENSCAFP00000010478 FSD-V-EENRTEAPEGTE------SEMETPSAI---NGNPSWHLADSPA--VNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQV H_sapiens_ENSP00000365230 FSD-V-EENRTEAPEGTE------SEMETPSAI---NGNPSWHLADSPA--VNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQV P_pygmaeus_ENSPPYP00000012163 FSD-V-EENRTEAPEGTE------SEMETPSAI---NGNPSWHLADSPA--VNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQV P_troglodytes_ENSPTRP00000022903 FSD-V-EENRTEAPEGTE------SEMETPSAI---NGNPSWHLADSPA--VNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQV R_norvegicus_ENSRNOP00000003768 GDE-D---SAPLRAAPTPGIFSFQPESNRTPAVHRDTAARTSPLRPLV-----ATAGPA--LS----PVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTP-------FTARGRFATV M_musculus_ENSMUSP00000108371 GDA-D---AAPLGAAPTPGIFSFQPESNPMPAVHRDMAARTSPLRPLV-----ATAGPA--LS----PVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTP-------FTARGRFATV M_mulatta_ENSMMUP00000007865 FSD-V-EENRTEAPEGTE------SEMETPSAI---NGNPSWHLVDSPA--VNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQV R_norvegicus_ENSRNOP00000040259 FSD-V-EENRTEAPEETE------PERETPSAI---NGNPSWHLADSPA--VNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQV M_mulatta_ENSMMUP00000008651 GDV-G---AATPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLPTPAAPAAAAAAGPA--LS----PVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTP-------FTARGRFATV H_sapiens_ENSP00000381185 GDV-G---AAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAP--GAAAGPA--LS----PVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTP-------FTARGRFATV P_troglodytes_ENSPTRP00000017121 GDV-G---AAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAP--GAAAGPA--LS----PVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTP-------FTARGRFATV P_pygmaeus_ENSPPYP00000010339 GDV-G---AAPPGAATAPGIFSSQPGHTPHPAASRDP-ARTSPLPTPAAP--GAAVGPA--LS----PVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTP-------FTARGRFATV G_gorilla_ENSGGOP00000000778 GDV-G---AVPPGAAPAPGIFSSQPGHTPHPAASRDRVARTSPLQTPAAP--GAAAGPA--LS----PVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTP-------FTARGRFATV G_gallus_ENSGALP00000020984 GED-RPPVPP----APAPAAAPAAVAAAGAS-------SHHRPEPPGSAA--ASEVPPAEGLR----PAPPGVHLALRQAGDEFSRRYQRDFAQMSGQLHLTP-------FTAHGRFVAV T_nigroviridis_ENSTNIP00000002788 EEV-QDQNAANNGSVVAPAPTLVRRCHEAGTGP--DRGSIPHLCKRTPQS-----------------EQHAAIHRVLREAGDELERLYQPDFTEMSRQLYLTS-------TTAQRRFAEV M_musculus_ENSMUSP00000086454 FSD-V-EENRTEAPEETE------AERETPSAI---NGNPSWHLADSPA--VNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQV O_cuniculus_ENSOCUP00000002775 FSD-V-EENRTEAPEGTG------PEMETPSAI---NGNPAWHPADSPA--VNGATGHSSSLDAREVIPMTAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQV O_latipes_ENSORLP00000017513 LKP-TDDGGETEEDHSD--ARNRRLVSSEDGR-------------------LRRSCPCC--------ASMDAIKSTLKDSADEFERRFHQGFSDLSVQLHITP-------DTAYQNFKRV G_aculeatus_ENSGACP00000013488 LRP-EDAGGRTEGDKANS-ASVPG------------RGSSAGQPGMSSP-----PPPPS--------GDTEAVKAALQDSANEFELLFTQAFSDLSLQLDVTP-------DTAYHSFKSV R_norvegicus_ENSRNOP00000038537 -------------------------------------------------------------------SAPSKTSRVLQRVAFSVQKEVEKNLKPYLDDFHVESI------DTARIIFNQV B_taurus_ENSBTAP00000025701 --------P-----------------------------SRTSPPPPPA-----AAAGPA--PS----PVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTP-------FTARGRFATV T_rubripes_ENSTRUP00000014135 NGLILEPPSRTDG---------QFVTTQFNGTF---NGASPGTPPATSL---------A--------TSLDTVKEALRDTGNEFELRYTCAFSDLHNQLHITP-------ATAYQSFENV D_rerio_ENSDARP00000095258 IGL-TEDTNRTDGAEENG-EGAAGATTLVNGTMNRTNASSTGTPPQSPASSPQRQTNGS--------GGLDAVKEALRDSANEFELRYSRAFNDLSSQLHITP-------ATAYQSFESV E_caballus_ENSECAP00000017850 GDA-G---AAPLGATPVPGIFSSQPGRTPAP-------ARTSPLLPPAAP--AGAAGPA--LS----PVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTP-------FTARGRFATV G_aculeatus_ENSGACP00000005643 IGL-SEPPNRTGGGVEAGAAGGQRGATHSNGTF---NGTSPGTPPASPL--LQQRSPST--------ASLDAVKEALRDSANEFELRYARAFSDLHNQLHITP-------ATAYQSFEDV G_aculeatus_ENSGACP00000018978 SPE-QLGGRPNEHQD----------------------------------------------------PQIKEVVKQLMKIADEMNRN-----AELQRLISQVPG------NCAQDIFMKV C_familiaris_ENSCAFP00000000102 GEA-G---AAPPGAAPAPGISAS--------------------------------------XS----PVPPVVHLTLRQAGDDFSRRYRR-FAEMSSQLHLTP-------FTARGRFATV T_nigroviridis_ENSTNIP00000013781 RAS-ADAWQSPRISRRDRSGASPSSD-----------------------------------------AGRRAVKAVLRKATDDFEKKLTRACGDLSS--YLPS-------KISHQNFNNT T_nigroviridis_ENSTNIP00000007577 I---VEPSSRTEG---------QFGTTQSNGTF---NGASPGTPPAPSQ-----HQQSL--------TSLDAVKEALRDTGNEFELRYTCAFSDLHNQLHITP-------ATAYQSFENV 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0085443 AKDLFRS-------------------------------S-ITWGKIISIFAVCGGFAIDCV-RQGHFDYL---QCLIDGLAEII-EDDLVYWLIDNGGWL-GLSRHIRPRVGE------- A_aegypti_AAEL001515-PA AKDLFKT-------------------------------D-ITWGKVISLFAIAGGLAVDCV-RQEHYDYL---QQLIEGTTDVI-EEDLSLWLVEKGGWL-GLHDHVHPPQTE------- A_gambiae_AGAP011552-PA AKDLFKS-------------------------------G-ITWGKVISLFAIAGGLAVDCV-RQDHADYL---QQLIEGTADVI-EEDLSGWLVERGGWL-GLQDHVHPPQPE------- A_aegypti_AAEL001521-PA ARDLFRS-------------------------------D-ITWGKVVSLFAIAGGLSVDCV-RQGHPDYL---PKLIEGVADVI-EDELVTWISENGGWV-GLANKVRPPQEE------- D_melanogaster_FBpp0087182 GRELFRV-------------------------------E-ITWSKVISLFAIAGGLSVDCV-RQGHPEYL---PKLMESVSEVI-EDELVPWINENGGWS-GINTHVLPTTNS------- T_nigroviridis_ENSTNIP00000005841 AADIFST-------------------------------G-VTWGKVVSLYAVAGALAVDCV-RHGHPAMV---HTIVDCMGEFV-RKSLTSWLKRRGGWV-DVTRCVVNTNPN------- O_anatinus_ENSOANP00000008963 ATQIFSA-------------------------------G-ITWGKVVSLYAVAAGLAVDCV-KQGQPAMV---HTIVDCLGEFV-RKTLVTWLKRRGGWA-DIMKCVVNTDPS------- G_gallus_ENSGALP00000009257 AAQIFTA-------------------------------G-ITWGKVVSLYAVAAGLAVDCV-RHAQPAMV---HTIVDCLGEFV-RKTLVTWLKRRGGWA-DITKCVVSTDPS------- G_aculeatus_ENSGACP00000006084 AADIFST-------------------------------G-VTWGKVVSLYAVAGALAVDCV-RHGHPAIV---HTIVDCMGEFV-RKSLTTWLKRRGGWV-DVTKCVVNTDPS------- T_rubripes_ENSTRUP00000030263 AADIFST--------------------EYILR--QRYEG-VTWGKVVSLYAVAGALAVDCV-RHGHPAMI---HTIVDCMGEFV-RKSLISWLKRRGGWV-DVTKCVVNTDPN------- T_guttata_ENSTGUP00000006267 ATQIFSA-------------------------------G-ITWGKVVSLYAVAAGLAVDCV-RHAQPAMV---HTIVDCLGEFV-RKTLVTWLKRRGGWA-DITKCVVNTDPN------- T_nigroviridis_ENSTNIP00000018321 ATEILST-------------------------------G-ITWGKVVSMYAVAGALAVDCV-RQGHPTTV---HILVDSLGQFV-RRFLVPWLKRRGGWA-DITRCVVRKDLA------- D_rerio_ENSDARP00000068408 AAEIFST--------------------EYSRKGLEKHKG-VTWGKIVSLYAVAGALAVDCV-RHGHPAMV---HTIVDCMGEFV-RKSLASWLKKRGGWA-DITKCVVSTDPS------- M_domestica_ENSMODP00000020066 ATQIFAA-------------------------------G-ITWGKVVSLYAVAAGLAVDCV-KQAQPAMV---HTIVDCLGEFV-RKTLVTWLKRRGGWA-DIMKCVVDSDPS------- A_carolinensis_ENSACAP00000000851 ATQIFSS-------------------------------G-ITWGKIVSLYAVAAGLAVDCV-RHAQPAMV---HTIVDCLGEFV-RKTLVTWMKRRGGWS-DITKCVVNTDPN------- O_latipes_ENSORLP00000002641 AADIFST-------------------GRISEKQNHCHKR-ITWGKVVSLYAVAGALAVDCV-RHGHPAMV---HTIVDCMGEFA-RKSLTVWLKKRGGWV-DMTKCVVNTDPS------- G_aculeatus_ENSGACP00000018053 ATEIFST-------------------------------G-ITWGKVVSMYAVAGALAVDCV-RQGHPATV---HILVASLGQFV-RKFLVPWLKRRGGWA-EMCKCVLKKDLP------- T_rubripes_ENSTRUP00000018728 ATEILST--------------------GTNQRFLTKIQG-ITWGKVVSMYAVAGALAVDCV-RQGHATTV---HILVDSLGQFV-RKFLVPWLKRRGGWA-DISRCVVKKDLA------- H_sapiens_ENSP00000314132 AGHIFSA-------------------------------G-ITWGKVVSLYAVAAGLAVDCV-RQAQPAMV---HALVDCLGEFV-RKTLATWLRRRGGWT-DVLKCVVSTDPG------- G_gorilla_ENSGGOP00000015296 AGHIFSA-------------------------------G-ITWGKVVSLYAVAAGLAVDCV-RQAQPAMV---HALVDCLGEFV-RKTLATWLRRRGGWT-DVLKCVVSTDPG------- M_mulatta_ENSMMUP00000007481 AGHIFSA-------------------------------G-ITWGKVVSLYAVAAGLAVDCV-RQAQPAMV---HALVDCLGEFV-RKTLATWLRRRGGWT-DVLKCVVSTDPG------- P_pygmaeus_ENSPPYP00000014939 AGHIFSA-------------------------------G-ITWGKVVSLYAVAAGLAVDCV-RQAQPAMV---HALVDCLGEFV-RKTLATWLRRRGGWT-DVLKCVVSTDPG------- M_musculus_ENSMUSP00000027499 AGHIFSA-------------------------------G-ITWGKVVSLYSVAAGLAVDCV-RQAQPAMV---HALVDCLGEFV-RKTLATWLRRRGGWT-DVLKCVVSTDPG------- R_norvegicus_ENSRNOP00000024693 AGHIFSA-------------------------------G-ITWGKVVSLYSVAAGLAVDCV-RQAQPAMV---HALVDCLGEFV-RKTLATWLRRRGGWT-DVLKCVVSTDPG------- O_latipes_ENSORLP00000020538 ATEIFSA--------------------VFSAKTQQTDSI-ITWGKVVSMYAVAGALAVDCV-RQGYLTTV---HILVDSLGQFV-RKFLVHWLKRRGGWA-EITKCVVKKELT------- B_taurus_ENSBTAP00000011478 ATQIFSA-------------------------------G-ITWGKVVSLYSVAAGLAVDCV-RQAQPALV---HALVDCLGEFV-RKTLATWLRRRGGWT-DVLKCVVSTDPG------- D_rerio_ENSDARP00000090569 ATEVIAM--------------------DYATNTVFDFKG-ITWGKVVAIYAVAAGLAVDCV-RLGHPVMV---HTIVDSLGEFV-RRSLVPWLKKRGGWV-DILKCVVNMDSR------- C_intestinalis_ENSCINP00000019812 GVHIMGV----------------------------VECN-YTWGRILSLLGLAGAMAVDCI-SQGHPELA---ESMIGISSDFI-QRNALDWIIKHGGWG-GLVDNFSPKPMK------- C_intestinalis_ENSCINP00000016140 AGEILTTEPVTIPKEATVNGETKKEKSRAFVSSGSRIIE-ITWGRICAVVAIAGGLSIDCV-NQGHSDLV---NQLIEFCGEFASEEGVLRWIVSQGGWE-TLREMTDDHSAS------- X_tropicalis_ENSXETP00000053903 VGELFRD-------------------------------G-TNWGRIVAFFSFGRALCVESA-NKEMTELL---PRIVQWMVQYL-EHTLQPWMLENGGWE-AFVGLYGKGAAAQSR---- T_rubripes_ENSTRUP00000012873 IDELFRD-------------------------------G-VNWGRIIAFFEFGGAVCAECAAKEEMSPQV---DNIAEWMTEYL-NGSLNSWIQDNGGWQ-RALEMAAPSLAPIGP---- O_latipes_ENSORLP00000021005 IDELFRD-------------------------------G-VNWGRIIAFFEFGGTVCVECASNEEMSTQV---ASIAEWMTEYL-NGPLNSWIEENGGWM-CRLGLFGKKRAVYRF---- T_guttata_ENSTGUP00000002093 VEELFRD-------------------------------G-VNWGRIVAFFEFGGVMCVESV-NREMFPLV---DNIATWMTEYL-NRHLHNWIQDNGGWD-AFVELYGNNMRPLFD---- T_rubripes_ENSTRUP00000032199 MDEVFKD-------------------------------G-VNWGRVVGLFAFGGVLCVECV-EKDASQLV---CRIADWMTIYL-DEHINPWIQSQGGWD-CFAKIFGDDAAAEGR---- M_domestica_ENSMODP00000024313 VNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESV-DKEMEVLV---GRITSWMATYL-DDHLDPWIQENGGWD-TFVELYGNDAAAESR---- G_aculeatus_ENSGACP00000017662 IDELFRD-------------------------------G-VNWGRIIAFFEFGGTVCAECVAKEEMASQV---DNIAEWMTEYL-NGPLNIWIQDNGGW--------------------- T_nigroviridis_ENSTNIP00000010122 MDEVFKD-------------------------------G-VNWGRIVGLFAFGGVLCVECV-EKDASELV---CRIADWMTIYL-DEHINPWIQSQGGWD-SFAQIFGKDAAAEGR---- D_rerio_ENSDARP00000096467 AEELFRD-------------------------------G-VNWGRIIAFFEFGGTMCVESV-NREMASQV---DNIAHWMTDYL-NGPLENWIEENGGWD-AFVEMYGQQRDSVFH---- T_guttata_ENSTGUP00000006866 VNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESV-VKEMRVLV---KRIVSWMTTYL-TDHLDPWIQENGGWE-RFVDSM-NDAAAEMR---- B_taurus_ENSBTAP00000008572 VNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESV-DKEMQVLV---SRIATWMATYL-NDHLEPWIQENGGWD-TFVELYGNNAAAESR---- E_caballus_ENSECAP00000014770 VNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESV-DKEMQVLV---SRIATWMATYL-NDHLEPWIQENGGWD-TFVELYGNNAAAESR---- G_gallus_ENSGALP00000010059 VNELFHD-------------------------------G-VNWGRIVAFFSFGGALCVESV-DKEMRVLV---GRIVSWMTTYL-TDHLDPWIQENGGWE-RFVDLYGNNAAAELR---- C_familiaris_ENSCAFP00000010478 VNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESV-DKEMQVLV---SRIAAWMATYL-NDHLEPWIQENGGWD-TFVELYGNNAAAESR---- H_sapiens_ENSP00000365230 VNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESV-DKEMQVLV---SRIAAWMATYL-NDHLEPWIQENGGWD-TFVELYGNNAAAESR---- P_pygmaeus_ENSPPYP00000012163 VNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESV-DKEMQVLV---SRIAAWMATYL-NDHLEPWIQENGGWD-TFVELYGNNAAAESR---- P_troglodytes_ENSPTRP00000022903 VNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESV-DKEMQVLV---SRIAAWMATYL-NDHLEPWIQENGGWD-TFVELYGNNAAAESR---- R_norvegicus_ENSRNOP00000003768 VEELFRD-------------------------------G-VNWGRIVAFFEFGGVMCVESV-NREMSPLV---DNIALWMTEYL-NRHLHTWIQDNGGWD-AFVELYGPSMRPLFD---- M_musculus_ENSMUSP00000108371 VEELFRD-------------------------------G-VNWGRIVAFFEFGGVMCVESV-NREMSPLV---DNIALWMTEYL-NRHLHTWIQDNGGWD-AFVELYGPSMRPLFD---- M_mulatta_ENSMMUP00000007865 VNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESV-DKEMQVLV---SRIAAWMATYL-NDHLEPWIQENGGWD-TFVELYGNNAAAESR---- R_norvegicus_ENSRNOP00000040259 VNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESV-DKEMQVLV---SRIASWMATYL-NDHLEPWIQENGGWV-RTTPLVCPPLVCLSSVEIP M_mulatta_ENSMMUP00000008651 VEELFRD-------------------------------G-VNWGRIVAFFEFGGVMCVESV-NREMSPLV---DNIALWMTEYL-NRHLHTWIQDNGGWD-AFVELYGPSMRPLFD---- H_sapiens_ENSP00000381185 VEELFRD-------------------------------G-VNWGRIVAFFEFGGVMCVESV-NREMSPLV---DNIALWMTEYL-NRHLHTWIQDNGGWD-AFVELYGPSMRPLFD---- P_troglodytes_ENSPTRP00000017121 VEELFRD-------------------------------G-VNWGRIVAFFEFGGVMCVESV-NREMSPLV---DNIALWMTEYL-NRHLHTWIQDNGGWD-AFVELYGPSMRPLFD---- P_pygmaeus_ENSPPYP00000010339 VEELFRD-------------------------------G-VNWGRIVAFFEFGGVMCVESV-NREMSPLV---DNIALWMTEYL-NRHLHTWIQDNGGWD-AFVELYGPSMRPLFD---- G_gorilla_ENSGGOP00000000778 VEELFRD-------------------------------G-VNWGRIVAFFEFGGVMCVESV-NREMSPLV---DNIALWMTEYL-NRHLHTWIQDNGGWX-XXXELYGPSMRPLFD---- G_gallus_ENSGALP00000020984 VEELFRD-------------------------------G-VNWGRIVAFFEFGGVMCVESV-NREMSPLV---DNIATWMTEYL-NRHLHNWIQDNGGWD-AFVELYGNSMRPLFD---- T_nigroviridis_ENSTNIP00000002788 IDELFRD-------------------------------G-VNWGRIIAFFEFGAAVCAECAAKEEMSPQV---DNIAEWMTEYL-SGSLNSWIQDNGGWR-RFKKVTG------------ M_musculus_ENSMUSP00000086454 VNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESV-DKEMQVLV---SRIASWMATYL-NDHLEPWIQENGGW------------GVSGG---- O_cuniculus_ENSOCUP00000002775 VNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESV-DKEMEVLV---SRIAAWMATYL-NDHLEPWIQENGGW--------------------- O_latipes_ENSORLP00000017513 LDELFKD-------------------------------G-INWGRVVGLFVFGGALCVECV-ERNMGELV---SRIAEWMTQYL-DEQISPWIHSHGGWD-CFARLYGQNGAAEAR---- G_aculeatus_ENSGACP00000013488 MDEVFKD-------------------------------G-VNWGRVVGLFAFGGVLCVECV-EKDMTELV---SRIADWMTTYL-DEHISAWIQSQGGWD-CFADIFGRDGAAAAR---- R_norvegicus_ENSRNOP00000038537 MEKEFED-------------------------------GIINWGRIVTIFAFGGVLLKKLP-QEQIALDVDTYKQVSSFVAEFI-MNNTGEWIQQNGGWEDGFTKKFEPK---------- B_taurus_ENSBTAP00000025701 VEELFRD-------------------------------G-VNWGRIVAFFEFGGVMCVESV-NREMSPLV---DSIALWMTEYL-NRHLHTWIQDNGGWV-GARLDVSLSGTPRSQCGPS T_rubripes_ENSTRUP00000014135 MDEVFRD-------------------------------G-VNWGRIVGLFAFGGALCVECV-EKEMSPLV---GRIIEWMTVYL-DNHIQPWIQSQGGWV-RFAELFGQDAAAESR---- D_rerio_ENSDARP00000095258 MDEVFRD-------------------------------G-VNWGRIVGLFAFGGALCVECV-EKEMSPLV---GRIAEWMTVYL-DNHIQPWIQSQGGWE-RFAEIFGKDAAAESR---- E_caballus_ENSECAP00000017850 VEELFRD-------------------------------G-VNWGRIVAFFEFGGVMCVESV-NREMSPLV---DNIALWMTEYL-NRHLHTWIQDNGGWD-AFVELYGPSMRPLFD---- G_aculeatus_ENSGACP00000005643 MDEVFRD-------------------------------G-VNWGRIVGLFAFGGALCVECV-DKEMSPLV---GRIVEWMTLYL-DNHIQPWIQNQGGWR-SDI---------------- G_aculeatus_ENSGACP00000018978 AKSIFDD-------------------------------G-INWGRVVALFHLAYRLIYRAL-TTNHLENI---RIIIGWVLRFI-RERLYPWLVQQGGWV-GVINGF------------- C_familiaris_ENSCAFP00000000102 VEELFRD-------------------------------G-VNWGRIVAFFEFGGVMCVESV-NREMSPLV---DNIALWMTEYL-NRHLHTWIQDNGGWV-GARLLEWESG--------- T_nigroviridis_ENSTNIP00000013781 MDQIFEG-------------------------------N-VHWGVVIGLFVVGGAMCVQCV-RNNHEELV---CHIADWMTAYL-DEHLEPWIQRQGGWE-DFTRRY---ETVDER---- T_nigroviridis_ENSTNIP00000007577 MDEVFRD-------------------------------G-VNWGRIVGLFAFGGALCVECV-EKEMNPLV---GRIIEWMTVYL-DNHIQPWIQSQGGWE-RFAELFGQDAAAESR---- 490 500 510 520 530 540 550 560 =========+=========+=========+=========+=========+=========+=========+=========+========= D_melanogaster_FBpp0085443 -----------FTFLGW-LTLFVT-------ISAG----------------AYMVSNVCRRI--------GGQLY----SLLF------ A_aegypti_AAEL001515-PA -----------ITFLGW-MAITIS-------TLFV----------------IYLISVLLKYL--------GSSYL----SKI------- A_gambiae_AGAP011552-PA -----------ISVTGW-VSITAL-------TLAV----------------IYIVSLFLRVI--------GSGYAEPERSTN------- A_aegypti_AAEL001521-PA -----------ITFAGR-CFVGAG-------LLVF----------------FKKDRTPQKFL--------INLHLQSKQNREDQSDLEV D_melanogaster_FBpp0087182 -----------LNPLEW-TTLVIG-------VVFG----------------LILVFMILRFI--------FNLIV----PKIYQRFTNS T_nigroviridis_ENSTNIP00000005841 ------------FDSHW-LVSALR-------AF-G----------------SYLKATVLYLL--------REK---------------- O_anatinus_ENSOANP00000008963 ------------LRSHW-LVAAVC-------SF-G----------------HFLKAIFFVLL--------PER---------------- G_gallus_ENSGALP00000009257 ------------LRSHW-LVAAVC-------SF-G----------------HFLKAIFFVLL--------PER---------------- G_aculeatus_ENSGACP00000006084 ------------FRSHW-LVSAVC-------AF-G----------------HYLKATVLYLL--------RDT---------------- T_rubripes_ENSTRUP00000030263 ------------FHSHW-LMSALC-------AF-G----------------NYLKTTVLYLL--------REK---------------- T_guttata_ENSTGUP00000006267 ------------LRSHW-LVAAVC-------SF-G----------------HFLKAIFFVLL--------PER---------------- T_nigroviridis_ENSTNIP00000018321 ------------PEHHW-LFSSVD-------SL-K----------------YFLTTIYVYIM--------KEA---------------- D_rerio_ENSDARP00000068408 ------------FHSHW-LVTAAC-------AC-G----------------HYLKAVVFYLL--------REK---------------- M_domestica_ENSMODP00000020066 ------------LRSHW-LVAALC-------SF-G----------------HFLKAIFFVLL--------PER---------------- A_carolinensis_ENSACAP00000000851 ------------LRSHW-LVAAIC-------SF-G----------------HFLKAIFFVLL--------PER---------------- O_latipes_ENSORLP00000002641 ------------FHSHW-LLAAVC-------AF-G----------------HYLKAVVLHLL--------REK---------------- G_aculeatus_ENSGACP00000018053 ------------PEHHW-LSSAMD-------SL-K----------------YFLTALYVCVM--------KEP---------------- T_rubripes_ENSTRUP00000018728 ------------PEHHW-LSSSVE-------SL-K----------------YFLSTVYVYIM--------KEA---------------- H_sapiens_ENSP00000314132 ------------LRSHW-LVAALC-------SF-G----------------RFLKAAFFVLL--------PER---------------- G_gorilla_ENSGGOP00000015296 ------------LRSHW-LVAALC-------SF-G----------------RFLKAAFFVLL--------PER---------------- M_mulatta_ENSMMUP00000007481 ------------LRSHW-LVAALC-------SF-G----------------RFLKAAFFVLL--------PER---------------- P_pygmaeus_ENSPPYP00000014939 ------------LRSHW-LVAALC-------SF-G----------------RFLKAAFFVLL--------PER---------------- M_musculus_ENSMUSP00000027499 ------------FRSHW-LVATLC-------SF-G----------------RFLKAAFFLLL--------PER---------------- R_norvegicus_ENSRNOP00000024693 ------------FRSHW-LVATLC-------SF-G----------------RFLKAAFFLLL--------PER---------------- O_latipes_ENSORLP00000020538 ------------SEQPW-LSSIME-------SV-K----------------YALTTLYVYVM--------KET---------------- B_taurus_ENSBTAP00000011478 ------------LRSHW-LVAALC-------SF-G----------------RFLKAAFFMLL--------PER---------------- D_rerio_ENSDARP00000090569 ------------AHVHW-LSTAVL-------TW-R----------------EFIKTMYVYLT--------K------------------ C_intestinalis_ENSCINP00000019812 --------------SYW-STRNILKWNGGVTLAVF----------------ILLFALMLAIL--------PRLKTNDN----------- C_intestinalis_ENSCINP00000016140 -----------HTANDYGYLTHIC-------NV-A----------------LALTACTLATV--------LSVVA---IASVSDTAG-- X_tropicalis_ENSXETP00000053903 --------EGPERFGRW-LMAIVT-------VT--------------------AATLLVSYL--------RRR---------------- T_rubripes_ENSTRUP00000012873 --------------RGWLS---------------------------------------------------------------------- O_latipes_ENSORLP00000021005 --------EYPKTSSRW-CCAIHS-------LI--------------------AGSKLPLEL--------AAR---------------- T_guttata_ENSTGUP00000002093 --------------FSWISLKTIL-------SLVL----------------VGACITLGAYL--------GHK---------------- T_rubripes_ENSTRUP00000032199 --------RARENLSRW-MLGGLA-------LL--------------------MGVLVGAFI--------VKKH--------------- M_domestica_ENSMODP00000024313 --------KGQERFNRW-LLTGMT-------VA--------------------GVVLLGSLF--------SRK---------------- G_aculeatus_ENSGACP00000017662 ----------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000010122 --------RAREALSRW-MLGGLA-------LL--------------------MGVLVGVFI--------VKKH--------------- D_rerio_ENSDARP00000096467 --------PFSYLTKVL-GLAALG-------L---------------------AGVTIGAFF--------AQK---------------- T_guttata_ENSTGUP00000006866 --------KGQE-FNKW-LLTGAT-------VA--------------------GVLLLGSLL--------SRK---------------- B_taurus_ENSBTAP00000008572 --------KGQERFNRW-FLTGMT-------VA--------------------GVVLLGSLF--------SRK---------------- E_caballus_ENSECAP00000014770 --------KGQERFNRW-FLTGMT-------VA--------------------GVVLLGSLF--------SRK---------------- G_gallus_ENSGALP00000010059 --------KGQETFNKW-LLTGAT-------VA--------------------GVLLLGSLL--------SRK---------------- C_familiaris_ENSCAFP00000010478 --------KGQERFNRW-FLTGMT-------VA--------------------GVVLLGSLF--------SRK---------------- H_sapiens_ENSP00000365230 --------KGQERFNRW-FLTGMT-------VA--------------------GVVLLGSLF--------SRK---------------- P_pygmaeus_ENSPPYP00000012163 --------KGQERFNRW-FLTGMT-------VA--------------------GVVLLGSLF--------SRK---------------- P_troglodytes_ENSPTRP00000022903 --------KGQERFNRW-FLTGMT-------VA--------------------GVVLLGSLF--------SRK---------------- R_norvegicus_ENSRNOP00000003768 --------------FSWLSLKTLL-------SLAL----------------VGACITLGAYL--------GHK---------------- M_musculus_ENSMUSP00000108371 --------------FSWLSLKTLL-------SLAL----------------VGACITLGAYL--------GHK---------------- M_mulatta_ENSMMUP00000007865 --------KGQERFNRW-FLTGMT-------VA--------------------GVVLLGSLF--------SRK---------------- R_norvegicus_ENSRNOP00000040259 NCPFWSPGMVVEDIDYSGDIPGFT-------LIPGVNFGNIDDPVFKEPVFFILATLVAPQFHSFVPISRQRKTACVFTWLKT------ M_mulatta_ENSMMUP00000008651 --------------FSWLSLKTLL-------SLAL----------------VGACITLGAYL--------GHK---------------- H_sapiens_ENSP00000381185 --------------FSWLSLKTLL-------SLAL----------------VGACITLGAYL--------GHK---------------- P_troglodytes_ENSPTRP00000017121 --------------FSWLSLKTLL-------SLAL----------------VGACITLGAYL--------GHK---------------- P_pygmaeus_ENSPPYP00000010339 --------------FSWLSLKTLL-------SLAL----------------VGACITLGAYL--------GHK---------------- G_gorilla_ENSGGOP00000000778 --------------FSWLSLKTLL-------SLAL----------------VGACITLGAYL--------GHK---------------- G_gallus_ENSGALP00000020984 --------------FSWISLKTIL-------SLVL----------------VGACITLGAYL--------GHK---------------- T_nigroviridis_ENSTNIP00000002788 ----------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000086454 --------TPLRSVFRR-LVQVPG-------VA--------------------EHVCDPSLW--------EVETE---GSEVQGPPQLL O_cuniculus_ENSOCUP00000002775 ----------------------------------------------------------------------------------------- O_latipes_ENSORLP00000017513 --------RFQETLKKW-MLVTVA-------LL--------------------TGLLLGVLI--------TKKR--------------- G_aculeatus_ENSGACP00000013488 --------RSQETMRRW-LLVGVA-------LL--------------------MGVLVGMVM--------VKKR--------------- R_norvegicus_ENSRNOP00000038537 --------------SGWLTFLQMT-----------------------------GKIWEMLFL--------LKQHY-------------- B_taurus_ENSBTAP00000025701 GGVWLGPG---SRAGRWSKTTCVA-------SLSLPLQRALPANPTVITPSLETLLPLSQPL--------RSKDPAFAAQ--------- T_rubripes_ENSTRUP00000014135 --------RSQERFRNG-LLVGMS-------LA--------------------AGIAIGSFI--------VRKLL-------------- D_rerio_ENSDARP00000095258 --------KSQESFKKW-LFAGMT-------LL--------------------TGVVVGGLI--------AQKRL-------------- E_caballus_ENSECAP00000017850 --------------FSWLSLKALL-------SLAL----------------VGACITLGAYL--------GHK---------------- G_aculeatus_ENSGACP00000005643 ----------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000018978 --------------SRWRNVAIVA----------S----------------VALVVALVYYR--------KTR---------------- C_familiaris_ENSCAFP00000000102 ----------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013781 --------SQFERGAKL-CFLTLV-------LL-V----------------GGFVIFRKYNV--------FHRLL---RFL-------- T_nigroviridis_ENSTNIP00000007577 --------RSQERFRNG-LFLGMS-------LA--------------------AGIALGSFI--------VMR----------------