10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0082755 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003444-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004920-PA --------------------------------------------------------------------------------VCGRDI-----------------LHCKTMNT--------- A_gambiae_AGAP004921-PA -------------------------------------------------------------------------------------------------------RSCNLMDD--------- A_gambiae_AGAP000830-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003439-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358327 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0071971 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011950-PA ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0084848 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP012945-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000019984 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009832-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002508 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004278 ------------------------------------------------------------------------------------------MSGSERRPPAGHVQLDSRPTL--------- G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------------------------------------MSDTTGDGRGGRVASPNKAAT--------- D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000019870 ------------------------------------------------------------------------------------------MSGAERRPAAGRVQLDSKPTP--------- A_gambiae_AGAP012544-PA ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003204 ----------------------------------------------------------------------------------------------MSLKSAADVLMSGVPTP--------- D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL014348-PA ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000005811 ------------------------------------------------------------------------------------------PRGATRLARGHP------------------ M_domestica_ENSMODP00000007353 ---------------------------------------------------------------------------------------------KSFGLFFVF------------------ C_intestinalis_ENSCINP00000011493 ------------------------------------------------------MDPHPADFPEPPPQPRITLRSDTVDSSVFHDDDNLF--SMDDAVEQPDSFDAVPPNSYPSPNSSLS D_rerio_ENSDARP00000006831 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000041413 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052017 ----------------------------------------------------------------------------------------MASAKQQSSPSAGQIEKDSSSAS--------- R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000050929 ------------------------------------------------------------------------------------------MASHTKSDGSAAVEKDSASAG--------- T_rubripes_ENSTRUP00000022652 ----------------------------------------------------------------------------------------------------GSDAELGKTAT--------- H_sapiens_ENSP00000265164 -------------------------------------------------------------------------------------------MSSASGLRRGH------------------ T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016744 -------------------------------------------------------------------------------------------MSSVSGLRRGH------------------ A_gambiae_AGAP004922-PA ---------------------------------------------------------------------------------------------------------CNLMDD--------- E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000016642 -------------------------------------------------------------------------------------------MSSEPPPRRAR------------------ T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028104 -------------------------------------------------------------------------------------------MSSASGLRRGH------------------ A_aegypti_AAEL012143-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000005531 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016791 -------------------------------------------------------------------------------------------SSATCGLRRAY------------------ G_gallus_ENSGALP00000013591 -----------------------------------------------------------MEFSQLLFVISEALDRTELASLKFLSLEHVTVRKREDIEEPKAFFQALQEKGMIEVGDLFF T_nigroviridis_ENSTNIP00000001216 --------------------------------------------------------------------------------------------------SAYQLFLSLCDQDHLSEERPHL C_familiaris_ENSCAFP00000017933 ------------------------------------------MTSQAQSLTFRSDDNCQSSFRGKLLTIDSKLEIQDVEGLKFLCRDFVSHKKLEKSNSASDIFDHLLAEELLSEEDPFF M_mulatta_ENSMMUP00000037892 VEGGRRARVVTESKRNFFLGACPTPFPTEHVELGRLGGSETAMVPGKGGADYILLPFEEMDFNRNLYDIGEQLDSEELASLKFLSLDCIPQRKQEPIKDALMLFQRLQEKRMLEENNLSF G_gallus_ENSGALP00000013506 -----------------------------------------LKSFKPHWISSNMEDDDSLQFRQLLLLIDEGLGAEDVAALKFLCTDLIPFRKLESVQSAMDIFQLLIDEDYLNEEDTFL C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005791 -----------------------------------------------------------MHFQKLLFDIGKALSGEEVKALAFLCTDILG-RNLSSVESASGLFSRLRDQGFLSAEQPHL A_carolinensis_ENSACAP00000001629 -------------------------------------------------------------FRQILLAIDENLGKEDVDAMKFLCSDFISTKHLEGVETAQDIFQLLINRNLLSKEDTFI D_rerio_ENSDARP00000075318 ---------------------------------------------------------------------MADQLLENLRPDLIKGLSERVINGLLDDLQQKKVFGEEEIEDIQHRMKTRA M_domestica_ENSMODP00000036247 -----------------------------------------------------------MDFHTFLYGIAEEIDSADLASLKFLCLDQIPLKKQQHIKDALVLFQTLEERGLLEEDNLFF P_troglodytes_ENSPTRP00000021879 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF C_intestinalis_ENSCINP00000011503 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000351273 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF D_rerio_ENSDARP00000075645 ------------------------------------------------------------------------------------------MDKTSNPNNSNQINRASPNEQ--------- M_musculus_ENSMUSP00000027189 -----------------------------------------------------------MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSF R_norvegicus_ENSRNOP00000016613 -----------------------------------------------------------MDFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQESINDVLVLFQRLQEEGMLEEDNLSF P_pygmaeus_ENSPPYP00000014606 -----------------------------------------------------------MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF D_rerio_ENSDARP00000063081 --------------------------------------------------------------------MSKKESTQRILQHKVFLIDTLSVEASFILQNVQQAKLITQRDYNNLSDVSER G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000286186 ------------------------------------------MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF D_rerio_ENSDARP00000075650 --------------------------------------------------------------------MDKKESVDKICENKIFLLETLSVDANFILQHVQQAKLITLRDYNNLSDFPQR O_anatinus_ENSOANP00000006351 -----------------------------------------------------------MDFHRLLFSIGEELAADDLEALKFLCLDLIPRKKQENIQDALGLFRLLQEKGMLEEGKLFF T_guttata_ENSTGUP00000010625 ------------------------------------------------------------DFRKLLFEVSEALVTEELSALKFLSLDHVPRRKLEAIHEPKAFFEVLQEKDMIGAGNLFF E_caballus_ENSECAP00000004055 -----------------------------------------------------------MNFNSCLYNIGEQLDSDELASLKFLSLDHIPQRKQEPIQDALMLFQRLQEKRLLEESNLSF O_cuniculus_ENSOCUP00000006164 -------------------------------ALVESGTVGDWVTVPGEGNGYXXXXXXXXXXXXXXXXXXEQLDSELL--LKF-ELDYIPQRKQEPIQDALMLFQRLQEKRMLEENNLAF T_rubripes_ENSTRUP00000044662 ---------------------------------------------------------CNMDFQARLLKVGNDLRKDEVRALVFLCSDILGCNP-AAVQSAGDLFSRLSDQDHLSEEQPHL C_familiaris_ENSCAFP00000017899 -----------------------------------------------------------MDFSKCLYNIGEQLDSDELASLKFLSLDYIPQKKQEPIKDPLMLFQRLQEKRMLEESNLFF P_pygmaeus_ENSPPYP00000014602 ------------------------------------------MKSQGQHWCSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCVGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF M_mulatta_ENSMMUP00000037898 ---------------------------------------------------------------------------------------------------------------------MRI D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030747 ---------------------------------------------------------------------MDEADRQLLRRCRVRLVSELQVAELWDALLSRELFTRDMIEDIQQAGSGSR E_caballus_ENSECAP00000021726 ------------------------------------------MTSQGQNLNSSSDDNCTMDFRQKLLFIDSHLGDQDVERLRFLCRDCVSHKKLEKSSSALEIFNHLLAEDLLREEDSFF G_gorilla_ENSGGOP00000000205 ---------------------------------------------------YILLPFEKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF X_tropicalis_ENSXETP00000008971 -----------------------------------------------------------MDFNSMLLSIDDGLGREDIEALKFLCRDVLRKNKLLSVRSGQELFQQLMTEDLINEDNFFL T_rubripes_ENSTRUP00000045375 ---------------------------------------------------------------------MEERHKKILQRNRTNLVGELDPSSLYDGLIEKRVFTHDMIDEIKSS--GTR P_troglodytes_ENSPTRP00000048878 ------------------------------------------MKSQGQHWCSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVP-KKLEKSSSASDVFEHLLAEDLLSEDDPFF M_domestica_ENSMODP00000005512 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011835 -------------------------------------------------------------------------------------------MSSAPGLRGAR------------------ T_guttata_ENSTGUP00000014729 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000004412 ---------------------------------------------------------------------MEESQRELFQKNRLRLVCELQVEPLWDLMLDRELFTRDMIEDIQRA--GTR B_taurus_ENSBTAP00000038128 -----------------------------------------------------------MALTQCLYNIGEQLGSDDLAALKFLSRDHIPYRKQEPIKDALMLFQRLQEKRMLEENNLSF G_gallus_ENSGALP00000013571 ---------------------------------------------------------MSSDFRKLLFDISEALATEELAALKFLSLEHVPVRKQEDTEEPKAFFEVLKEKGMIEVEDLFF B_taurus_ENSBTAP00000003205 ---------------------------------------------------------------------MNEADRLLLRRYRVRLVGELQVASLWDALLSRELFTPDMIEDIQRAGSGSR T_nigroviridis_ENSTNIP00000013855 ---------------------------------------------------------------------MEERHKKILQRNRINLVSELEPLNLYDGLIEKGVFTHDMIDEIKCS--GAR O_cuniculus_ENSOCUP00000003895 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000036251 -----------------------------------------------------MEDNSKIKFNQQLLSINEKLEPEEIEALKFLCSDLISPRNLEDIESGHQLFQKFMDEDLLNEGDYFL O_latipes_ENSORLP00000005993 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000007379 ---------------------------------------------------------------------MEEIHKRILQRNRINLVRDLDPSSLYDGLLEKGVFTQDMIDEIKSA--GTR R_norvegicus_ENSRNOP00000017972 ---------------------------------------------------------------------MEEADRQLLRRCRVRLVRELQVAELWDALLSRELFTRDMIEDIQRAGSGSR T_guttata_ENSTGUP00000017449 ---------------------------------------------------------------------MEERQRRALRRGRARLVAALRVEPLWEPLEQRGLFTRPMLEELQSA--GSR O_anatinus_ENSOANP00000015596 --------------------------------------------------------------------------------------------------------------------AGTR G_gallus_ENSGALP00000002083 ---------------------------------------------------------------------MEEAQRSALRRGRVRLVEGLRPEVLWGPLQARGVFTSAMVEDMQST--GTR T_guttata_ENSTGUP00000010628 -------------------------------------------------------------FRQQLFLISENLVTEDVAALKFLCTDLLHLRKLEGVKLATDIFRLLMAQEYLNAEDTFL C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------EFRLLLHQICEGLTGENVSMMKFLCKDAIPRSR--ELETALDFMEYFEAKGWIQEGDLGF C_elegans_C48D1.2 --------------------------------------------------------------------MMRQDRRSLLERNIMMFSSHLKVDEILEVLIAKQVLNSDNGDMINSCGTVRE C_intestinalis_ENSCINP00000028692 ----------------------------------------------------------------------------------------MSENKEKDIRESWSQENLPEAGH--------- T_rubripes_ENSTRUP00000024467 ------------------------------------------------------------MDLRLLSQIDAQLDSLEVAALCFLCRDAVSPKSREGITDARGLFKKLHEKRLLE--NSSF M_mulatta_ENSMMUP00000040583 ---------------------------------------------------------------------MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFKPHMIEDIQRAGSGSR R_norvegicus_ENSRNOP00000040783 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023986 ---------------------------------------------------------------------MDEAERRALRRCRVRLVRELQVAALWDALLSRELFTAAMVEDLQHAGSGSR E_caballus_ENSECAP00000015102 ---------------------------------------------------------------------MNEADRQLLRRSRLRLVRELQVDSLWDALLTRELFTPDMIEDIQR--SGSR D_rerio_ENSDARP00000047019 ---------------------------------------------------------------------MEQKHRQILQRHRLNLVKALNPEDVCDKLLSKGVFTQDMIDEIQSK--ATR P_troglodytes_ENSPTRP00000056642 ----------------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSR 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0082755 -----------------------------------------------------------------------------------------------------------------MDDTDFS A_aegypti_AAEL003444-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004921-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP000830-PA -----------------------------------------------------------------------------------------MSMPDVVDIRNEINKEHVRE---SLDRNGDE A_aegypti_AAEL003439-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003217 ----------------------------------------------------------------------------------------------------------------------ME A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------------------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQGCIE H_sapiens_ENSP00000358327 ------------------------------------------------------------------------------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQGCIE D_melanogaster_FBpp0071971 -----------------------------------------------------------------------------------------M------------TDECVTRNYGVGIRSPNG O_cuniculus_ENSOCUP00000009498 ---------------------------------------------------------------------------------------------------------------MADDQAHAG G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------------------------MDCVGWPPGRRWHLEKNTSCSGSSGICASYVTQMADDQGCVE R_norvegicus_ENSRNOP00000022693 ---------------------------------------------------------------------------------------------------------------MTDDQDCAA G_gallus_ENSGALP00000017288 ---------------------------------------------------------------------------------------------------------------------MMT B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011950-PA ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013731 ---------------------------------------------------------------------------------------------------------------MADDQDCVV P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------------------------------------------------------MAGEAAGIPELG D_melanogaster_FBpp0084848 -----------------------------------------------------------------------------------------MDATN--------NGESADQ---VGIRVGNP P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007184 ---------------------------------------------------------------------------------------------------------------MADDQGCVX T_guttata_ENSTGUP00000006879 ----------------------------------------------------------------------------------------------------------------------MT G_aculeatus_ENSGACP00000008661 ----------------------------------------------------------------------------------------------------------QVNGARLTSAQDVA C_familiaris_ENSCAFP00000016420 ---------------------------------------------------------------------------------------------------------------MADDQDCGM M_musculus_ENSMUSP00000026062 ---------------------------------------------------------------------------------------------------------------MTDDQDCAA M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP012945-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 ---------------------------------------------------------------------------------------------------------SMQMAGEPTEISDLG B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000019984 ----------------------------------------------------------------------MDKEALTSENEVSGDDQENYGKGDVTDAKPDPKAMCRVDKEALTSEIEVL C_familiaris_ENSCAFP00000032189 -------------------------------------------------------------------------------------------------MGEQRNTSSKELAAAEATGQSGK A_gambiae_AGAP009832-PA ------------------------------------------------------------------------------------------------------------------QPLTKA T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002508 ---------------------------------------------------------------------------------------------------------------MADDQAPTM R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004278 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000019870 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP012544-PA ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL014348-PA ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000005811 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007353 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011493 TSYSGGDILSMASPPLPVTRITERTQTAGEVIRTYNPSPE-----------------------------------------KRDHEVSYDELLEEDMKFSAEGVSDSVKHFYGAAIPVTC D_rerio_ENSDARP00000006831 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000041413 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000050929 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000265164 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000040691 ----------------------------------------------------------------------------------------------------------------------TN P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004922-PA ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000016642 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL012143-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 ---------------------------------------------------------------------------------------------------------------------MDM G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000005531 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013591 LKELLYRINRIDLLASYLGSSREEMERELQVPGRARVSPF--------------------------------R----YLLFQLSENITKDDMKCFKFLLG-KELPKCKLSPETTMPDVFI T_nigroviridis_ENSTNIP00000001216 LSELLSIIQRTRLL-RDLDLRSSATSNL--------ISAY--------------------------------R----KLLYSLSEDLTDDNLKEIKFLLT-ETLPRRKLEDNVTTLEVFL C_familiaris_ENSCAFP00000017933 LAELLYIIKQNSLL-RYLNQSKEQVESLL--PTRRRVSLF--------------------------------R----NLLYELSESIGSENLKDMIFLQR-DSMPKTQLT----PLSFLA M_mulatta_ENSMMUP00000037892 LKELLFRINRLDLLTTYLNTRKEEMERELQAPGRAQISAY--------------------------------R----VMLYQISEEVGRSELRSFKFLLQ-EEISKCKLDDDMNLLDIFV G_gallus_ENSGALP00000013506 LAELLYRIKYHSLL-SKLGYTKEKVQECL--HEKGKVSPY--------------------------------R----QMLYELSENITNDMLQEIVFLLR-NHLPKRRRT--ISALELLI C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005791 LTELLIIIQRVRLT-RDVDLPAEP---------SSLISPY--------------------------------R----KMLYNLSEELTADDLKDMKFLLH-SYLPRRKLEENVSTLEIWL A_carolinensis_ENSACAP00000001629 VAELLYRIKCHFLL-QKIGYTQQKVEHNL--FHIRNVSEY--------------------------------R----QMLYEISEGFTEENVKTAMFLLR-EHLPKKQSI----AVKLLT D_rerio_ENSDARP00000075318 DQAR-------------------------------------------------------------------------------------------------HVIDDVKRKGVKASEIMLA M_domestica_ENSMODP00000036247 LKELLFRINRIDLLNEPLNTKGPEMERELQVPNKARISPYRLHLHTTIWPFRDNWTCRITLSVSFTSRTKQLLSVMVILLFNLSEGVGPSELKSIKFMLS-SKIPKCKIEDDMTLMDLFI P_troglodytes_ENSPTRP00000021879 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY--------------------------------R----VMLYQISEEVSRSELRSFKFLLQ-EEISKCKLDDDMNLLDIFI C_intestinalis_ENSCINP00000011503 ------------------------------------------------------------------------------------------------MERMSDETPRKPAAGDVLKIYKSE H_sapiens_ENSP00000351273 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY--------------------------------R----VMLYQISEEVSRSELRSFKFLLQ-EEISKCKLDDDMNLLDIFI D_rerio_ENSDARP00000075645 -----------------------------------------------------------------------------------------------------EKIKTDEPKRKNTSQEDKE M_musculus_ENSMUSP00000027189 LKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPY--------------------------------R----VMLFKLSEEVSELELRSFKFLLN-NEIPKCKLEDDLSLLEIFV R_norvegicus_ENSRNOP00000016613 LKELLFHISRRDLLSRVLKSSPEEMVRELQVLGKAQVSAY--------------------------------R----VMLFKLSEDMDKEDLKSFKFLLI-TEIPKCKLQDNSSLLDIFV P_pygmaeus_ENSPPYP00000014606 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWWRVDHILIR----VMLYQISEEVSRSELRCFKFLLQ-EEISKCKLDDDMNLLDIFI D_rerio_ENSDARP00000063081 ETKII------------------------------------------------------------------------------------------------KLLDKLIGRGEETCQEFID G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000286186 LAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLF--------------------------------R----NLLYELSEGIDSENLKDMIFLLK-DSLPKTEMT----SLSFLA D_rerio_ENSDARP00000075650 ETKII------------------------------------------------------------------------------------------------NLLDKLMGKGEETCHQFIA O_anatinus_ENSOANP00000006351 LKELLFRIHRIDLLTSHLRTSQEDVARELEEPGRAQVSAYS-------------------------------R----VLLFTLSDNVTREELKSITFFLS-NDLPRSRLDNKQTLMGIFI T_guttata_ENSTGUP00000010625 LKELLYRIHRIDLLSTPLGCSREEMERELQLPGRAQVSAY--------------------------------R----QLLYGIAEDLTSEDVRSVKFLLQ-KQLPKNKLQENASMLQVFL E_caballus_ENSECAP00000004055 LKELLFRINRLDLLTTELDTSKEEMERELQSPGRAQISAY--------------------------------R----VMLFQISEDVNKLELKSFKFLLS-RELPKCRLDDDMILLDIFI O_cuniculus_ENSOCUP00000006164 LKELLFRIHRLDLLSTLLGTSKEEMVTELQIPGRAHISAYX------------------------------------XXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXX T_rubripes_ENSTRUP00000044662 LVELLGIIQRTKLL-RDHNLPRTGAQDL--------ISPY-SCKS---------------------------R----KLLYSLSEELTADDLKDIKFLLN-NKLPRGKLEE-VTTLEVFM C_familiaris_ENSCAFP00000017899 LKELLFRINRLDLLMTYLDTSKEDMQQELQIPGRAQISAY--------------------------------R----VMLFQISEDVSKLELKSFKFLLS-REISRCKLDDDLNLLDIFI P_pygmaeus_ENSPPYP00000014602 LAELLYIIRQKKLL-QHLSYTKEEVEGLL--PTRQRVSLF--------------------------------R----NLLYELSEGIDSENLKDMIFLLK-DSLPKTEMT----SLSFPA M_mulatta_ENSMMUP00000037898 PTKWFYL----------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030747 RDQAR------------------------------------------------------------------------------------------------QLVTDLETRGRQALPLFIS E_caballus_ENSECAP00000021726 LAELLYIIKQKSLL-CHLCYTKEQVESLL--PARRRVSLF--------------------------------R----NLLYELSEGMDSDNLNSMMFLLK-DSIPKTQMT----SLSLLA G_gorilla_ENSGGOP00000000205 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY--------------------------------R----VMLYQISEEVSRSELRSFKFLLQ-EEISKCKLDDDMXLLDIFI X_tropicalis_ENSXETP00000008971 LKELLYIINHHSLL-RNLGTNKEKVQKAL--PRQGRISPYR------------------------------------QMLYQLSENIAGDDEKRVYFLLP----LQKKHKENKTFLEVLC T_rubripes_ENSTRUP00000045375 RDQAR------------------------------------------------------------------------------------------------QLIRDLETRGSRAFPLFLE P_troglodytes_ENSPTRP00000048878 LAELLYIIRQKKLL-QHLNYTKEEVERLL--PTRQRVSLF--------------------------------R----NLLYELSEGIDSENLKDMIFLLK-DSLPKTEMT----SLSFLA M_domestica_ENSMODP00000005512 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011835 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000014729 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000004412 RDQAR------------------------------------------------------------------------------------------------QLVTDLQTRGKRALPIFIS B_taurus_ENSBTAP00000038128 LKELLFRVNRLDLLLNYLYTSEEEMKRELQIPGRAQISAY--------------------------------R----ILLFQISEDVNKVELKDFKFFLS-QEIAKCKLDDDMTLLDIFV G_gallus_ENSGALP00000013571 LKELLYRINRIDLLASHLGSSREEMERELQVPGKAKVSAY--------------------------------R----QLLYGIAEDLTPDDVRSIKFLLQ-EKLPKNKLQDNASMLKVLV B_taurus_ENSBTAP00000003205 RDQAR------------------------------------------------------------------------------------------------QLILDLETRGSQALPLFIS T_nigroviridis_ENSTNIP00000013855 RDQAR------------------------------------------------------------------------------------------------QLVRDLETRGSRAFPAFLE O_cuniculus_ENSOCUP00000003895 -------------------------------------------------------------------------------------------------------------N----SLHLLE M_domestica_ENSMODP00000036251 VAELLFLIKHHNLL-QKIGYTKEKVKKEL--SSKRKISSY--------------------------------R----VMLYNLSEEITTEDFEHIKFIMK-EHIPKTLKT----FLSLLR O_latipes_ENSORLP00000005993 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000007379 RDQAR------------------------------------------------------------------------------------------------KLVQDLETRGSRAFAMLLL R_norvegicus_ENSRNOP00000017972 RDQAR------------------------------------------------------------------------------------------------QLVIDLETRGRQALPRFIS T_guttata_ENSTGUP00000017449 GEQAR------------------------------------------------------------------------------------------------QLIIDLETRGKQAFPAFLS O_anatinus_ENSOANP00000015596 RDQAR------------------------------------------------------------------------------------------------QLVTDLETRGRRALSVFIS G_gallus_ENSGALP00000002083 REQAR------------------------------------------------------------------------------------------------QLVIDLETRGKQAFPIFLS T_guttata_ENSTGUP00000010628 LAELLYRIRCHSLL-KKIGYTKEKVQEHL--SEKGRISPY--------------------------------R----QMLYELAENITSEMLKEIIFLLR-NHLPKG-----WSALDLLT C_intestinalis_ENSCINP00000024485 LAEVLYRINRHDLLKLLPGVKNRRDYEENFQAQQNNFTTYR------------------------------------VVCFMLADELTEGDLKILKRLCA-GKMSKANVRRSVDVLSWLT C_elegans_C48D1.2 KRR--------------------------------------------------------------------------------------------------EIVKAVQRRGDVAFDAFYD C_intestinalis_ENSCINP00000028692 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000024467 LSQLLHTIHRKDLLCLLEADSSQPEETDARPLLSEYR----------------------------------------VMLYKLYENLDREDLKKLKFLLS-DQLGRRQIELCKTVLDVFT M_mulatta_ENSMMUP00000040583 RDQAR------------------------------------------------------------------------------------------------QLITDLETRGSQALPSFIS R_norvegicus_ENSRNOP00000040783 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023986 SDQAR------------------------------------------------------------------------------------------------QLVIDLETRGSQALPLFIS E_caballus_ENSECAP00000015102 RDQAR------------------------------------------------------------------------------------------------QLIIDLETRGSQALLLFIS D_rerio_ENSDARP00000047019 RDQAR------------------------------------------------------------------------------------------------QLVKDLETRGSLAFPAFLD P_troglodytes_ENSPTRP00000056642 RDQAR------------------------------------------------------------------------------------------------QLIIDLETRGSQALPLFIS 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0082755 LFGQKNKHKKDKADATK------------------------------------------------------------------------------------------------------- A_aegypti_AAEL003444-PA ------MDTTDELDVLG------------------------------------------------------------------------------------------------------- A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004920-PA STLSTAFDEVDNNTRVLS------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004921-PA LPPEPTPDNEFYDGNIPS------------------------------------------------------------------------------------------------------ A_gambiae_AGAP000830-PA QQ-----LVQDVNDALG------------------------------------------------------------------------------------------------T------ A_aegypti_AAEL003439-PA ------MDTADELDVLG------------------------------------------------------------------------------------------------------- A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 -----MEDTGTTVDAKS------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000003217 ESHNGVQYGEDTADAKT------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005216 EQGVEDSANEDSVDAKP------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000358327 EQGVEDSANEDSVDAKP------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0071971 SENRGSFIMADNTDAKG------------------------------------------------------------------------------------------------C------ O_cuniculus_ENSOCUP00000009498 ELGAGDSESADAVDAKP------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 -----AASGEVMVDSKS------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 EQGLGDSANEDSVDAKP------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000022693 ELEMADSSTEDGVDAKP------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000017288 DIKDGPRSGEDVSDARS------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011950-PA ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013731 EQGAGDSTSTDAVDAKP------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000017020 -----MENTENSVDSKS------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000022078 GEAEGEHRCEDDVDAKP------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0084848 EQ------PNDHTDALG------------------------------------------------------------------------------------------------SVGSGGA P_troglodytes_ENSPTRP00000054330 -----MENTENSVDSKS------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000311032 -----MENTENSVDSKS------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007184 XXXXXXXXXXXXXXXXX------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006879 DIGDGAHLGKDLADTKS------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000008661 --AEEGGPTGDQTDAKP------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000016420 EQAAGDSESPDAVDARP------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000026062 ELEKVDSSSEDGVDAKP------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000091238 -----MENNKTSVDSKS------------------------------------------------------------------------------------------------------- A_gambiae_AGAP012945-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015808 -----MENTENSVDSKS------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000031759 GEVEEGGQSEDDVDAKP------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000021099 -----MENTENSVDSKS------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000019797 -----MENSKISVDSKS------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000019984 EEDQDSYGEEDVTDAKP------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000032189 ELEVSMENTENSVDAKS------------------------------------------------------------------------------------------------------- A_gambiae_AGAP009832-PA FSAMFSRKQEDSSDTRG------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 -----MEDTGTTVDAKS------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000002508 HQKECD--FEDEVDAKP------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000014096 -----MDNNETSVDSKS------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000004278 -PTTDGNENITEVDALN------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000023055 -DRAACTENLTETDALI------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000071815 -MSDVKPKGVDTVDARQ------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000012644 ---------------FR------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000019870 TTTADGNQNITEVDAFD------------------------------------------------------------------------------------------------------- A_gambiae_AGAP012544-PA MDATIINNNHSSLEA--------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000009934 MSANGPASGEDFTDASK------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000010095 --MASNRPGEDSTDARK------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000003204 HTNENNNVGQSEVDALG------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL014348-PA ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000005811 --AAGGAPNVTEVDGFY------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000007353 --EGDAEQNATEIDAFF------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011493 DDRVDTGAGYDTVDAGA------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000006831 -------MNGDCVDAKR------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000041413 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029626 ---------MTETDGFY------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000052017 -QNKEQKANVAETDGWT------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000013049 ---------MTETDGFY------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000050929 ---QTVEENLTETDSFN------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000022652 -DSSACTGDLMETDAIS------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000265164 --PAGGEENMTETDAFY------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000040691 MSANGPSPGGDFTDAKK------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000016744 --PAGGEENMTETDAFY------------------------------------------------------------------------------------------------------- A_gambiae_AGAP004922-PA LPPEPTPNNEFYDGNIPE------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013268 ----GEEQNMTEIDAFY------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000022402 --MSVNGPGEDRTDAKT------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000016642 --GPGEEQNMTEIDAFP------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000021186 ---------RMETDAFY------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000028104 --PAGGEENMTETDAFY------------------------------------------------------------------------------------------------------- A_aegypti_AAEL012143-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 AETAEELSGKDQVDTKP------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000005531 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016791 --RTADEQNVTETDAFY------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000013591 EMEKKGILKEDNLTVLKT-----ICGKVDKS-----LLKKIEDYE-----------------LNLLGEGEMLVTEGQRSSTGAPEDSAIWLASSVAPDSLGNCDQS-------------- T_nigroviridis_ENSTNIP00000001216 ELECMDLLSKTNLGLLKS-----ILQPVCPV-----LAERIRQFE------------AQN-------------------SCQPAADWGFAVKKITDPLQVQ--------GGSDALPSLPE C_familiaris_ENSCAFP00000017933 YLEKQALIDEDNLGLLED-----LCRKVVPN-----LIRKIERYK------------REKA--SEVVTPPVDTETESLHQKEEELFSPSDINQFHGALSKQTSWN--------------- M_mulatta_ENSMMUP00000037892 EMEKRVILGEGKLDILKR-----VCAQVNKS-----LLKIINDYE------------EFSRERTRSLEGSPEEGSNG--------EELCGLMTISDSPREQDSESQ-------------- G_gallus_ENSGALP00000013506 LLEKQCLLTENNVQILEE-----VFRNVSPD-----LLETVKCYR------------MAKVALPHQGNTLPIKESSPSYTVHVRLFNSPQGGSFILVLNESYCES--------------- C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005791 EMEHKDLMNEHNLHLLEI-----LISKVCPM-----LKDKINQLKAQQETPTSPATQESGRQGSLSAPNAPNQVPQSL------GAEGTGLFEMQDSPSGFNGGG--------------- A_carolinensis_ENSACAP00000001629 SLEKQDLLAEDKLAILEK-----ICNKVSPE-----LRNKVDKFK------------ERSVFKAFVFS-----------LCYENLYPSNFLAVFLLIL---------------------- D_rerio_ENSDARP00000075318 SLKTRDPHLYDTLGIER------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000036247 EMEKRGILGEGNLDALKI-----VCDQIDKS-----LLKKIQEYE------------ISKGRNNL-----------------FLIYQNTQPQEVYDSAG--------------------- P_troglodytes_ENSPTRP00000021879 EMEKRVILGEGKLDILKR-----VCAQINRS-----LLKIINDYE------------EFSKERSSSLEGSPDEFSNG--------EELCGVMTISDSPREQDSESQ-------------- C_intestinalis_ENSCINP00000011503 VKRNATSESDENIDAIS------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000351273 EMEKRVILGEGKLDILKR-----VCAQINKS-----LLKIINDYE------------EFSKERSSSLEGSPDEFSNG--------EELCGVMTISDSPREQDSESQ-------------- D_rerio_ENSDARP00000075645 NLHKGVQNNNSPKRQRE------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000027189 EMEKRTMLAENNLETLKS-----ICDQVNKS-----LLGKIEDYE------------RSSTERRMSLEGREEL------PPSVLDEMSLKMAELCDSPREQDSESR-------------- R_norvegicus_ENSRNOP00000016613 EMEKRTILAENNLVTLKS-----ICFRVNRS-----LLGRIDDYE------------RSSTERRMSTEGGEEL------PVSVLDEVTIKMQDMWDSPGEQESESL-------------- P_pygmaeus_ENSPPYP00000014606 EMEKRVILGKGKLDILKR-----VCAQINKS-----LLKIINDYE------------EFSRG-----------------------EELCGVMTISDSPREQDSESQ-------------- D_rerio_ENSDARP00000063081 LLRQDCVLENFPVLEGHA------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000286186 FLEKQGKIDEDNLTCLED-----LCKTVVPK-----LLRNIEKYK------------REKA--IQIVTPPVDKEAES-YQGEEELVSQTDVKTFLEALPQ-ESW---------------- D_rerio_ENSDARP00000075650 LLRQDCVLENFPMLKDHD------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000006351 EMEKKGILGESNLDMLKK-----ICDKIDKT-----LLGKIDHYE------------ERRADCTLHSSEHLTVLDRDMYIIPIIYDEIILLPTESSFRGHSGGEAE-------------- T_guttata_ENSTGUP00000010625 EMEIKGIIKEDNMTTLKD-----ILQRFRAD-----IKKKIDAYE------------EKKKGLTGSAEVSLEL------PVSWIDSVDHIKQSTLGLPGEDRSLSF-------------- E_caballus_ENSECAP00000004055 EMEKRVMLGERNLDTLKK-----ICEQVNKS-----LLKKINDYE------------ELSREGRISLERSPDEFSNAS-LKCLQREGSLAGQAMSDSPGQQNSESQ-------------- O_cuniculus_ENSOCUP00000006164 XXXXXXXXXXXXXXXXXX-----XXXXXXXX-----XXXXXXXXX------------XXXXXXXXXXXXXX--------XXXXXXXXXXXXXXXXXXXXXXXXXXX-------------- T_rubripes_ENSTRUP00000044662 ELEHRALISDTDLGFLES-----IIQPVCPV-----LLEKINQFN------------AQNCKMHLILHIFDSYLNQIQLNTQLKALW--LIKKF-DSFLVSFSSNESWIGGSGNRPT--- C_familiaris_ENSCAFP00000017899 EMEKRVILGERNLDTLKR-----ICDQINKS-----LLKKITDYE------------ELNREQTMNLQRSLDEISNDM-SQLPIREGSVKILPMSDSLGEQDYESE-------------- P_pygmaeus_ENSPPYP00000014602 FLEKQGKIDEDNLTCLED-----L-KTVVPK-----LLRNIEKYK------------REKA--VQIVTPPIDKEAES-YQGEEELVSQTDVKTFLEALPQEESW---------------- M_mulatta_ENSMMUP00000037898 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030747 CLEDTGQGTLASLLQSGR-----QAAKQDPE-----AVKPLDHLV----------PVVLGPMGLTAKEQRVVKLDPSQPAVGNLTPVVLGPEELW------------------------- E_caballus_ENSECAP00000021726 HLEKQARIDEDNLTLLEM-----LCKNVVPN-----LMRKIEKYK------------REKA--AQVVTAPVDKETESLHHGEEELFSRSDIKKFSRALPQ-------------------- G_gorilla_ENSGGOP00000000205 EMEKRVILGEGKLDILKR-----VCAQINKS-----LLKIINDYE------------EFSKERSSSLEGSPDEFSNG--------EELCGVMTISDSPREQDSESQ-------------- X_tropicalis_ENSXETP00000008971 QLERENSITEDDVELLED-----IFKKVAPD-----LLKIIEKYK-------ERGDKLHQTENHLIDPSAPPEDEHELINPPLSIQVSSKDSELWDKGTESLIEH--------------- T_rubripes_ENSTRUP00000045375 CLQETGHHTLVELLQDGG-----PAVQIQPPTPVPIDRPVIQPLP------VCKSAIRSRVLRGTMTVKAAPPVDVVR------------------------------------------ P_troglodytes_ENSPTRP00000048878 FLEKQGKIDEDNLTCLED-----LCTTVVPK-----LLRNIEKYK------------REKA--VQIVTPPVDKEAES-YQGEEELVSQTDVKTFLEALPQ-ESW---------------- M_domestica_ENSMODP00000005512 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011835 --LAGGKQNMTETDAFY------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000014729 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000004412 CLEATGQWDLAALLSESN-----TTLTQQPDPI---DIKPVEMIR---------SGGLRSTGRYTSMVSLHLLLLANSPFLYFIDAVLVSAHNLF------------------------- B_taurus_ENSBTAP00000038128 EMEKRTILGEENLDTLKR-----ICEQVNKS-----LLKKIYDYE------------ELRKERRMSLERDPYAFSNDM-SQSLPEEGYSKMPAMSDSP-EQDSELQ-------------- G_gallus_ENSGALP00000013571 EMERNGIIKEDDLTMLKS-----ILKAFRAD-----LKKKIDNYE------------EKTKGWPWKSSCFPNK------TQALSISENLAVSSLIDNKESQESQSEWY------------ B_taurus_ENSBTAP00000003205 CLEDTGQDTLASLLKTSR-----QAAKQ------------------------------------------------SKPSQGKLAPVVLGPEELW------------------------- T_nigroviridis_ENSTNIP00000013855 CLKETGYHSLAELLQNGA-----PTVQIQPPTPIPVDRPVIQPLP--------------------ISPPLVPP----------------------------------------------- O_cuniculus_ENSOCUP00000003895 HLEKRDDIHEDNLTYLED-----LCKKVAPS-----LMRIIEKYK------------NEKX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVT-------------------- M_domestica_ENSMODP00000036251 HMEKQNLLSENNLEILVN-----ICKPLSIN-----LIKRIEQYK------------SEKGELPEFELIP--------YHGCGVISEQVSLMTFLSLLPLFSWSR--------------- O_latipes_ENSORLP00000005993 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000007379 CLEETDQHGLAELLQRAA-----PAVQIWPAAP---NQPFVLMLN-----------SREKTTSPSIQYRNPVPVHLTH------------------------------------------ R_norvegicus_ENSRNOP00000017972 CLEDTGQGSLASFLQSSG-----QAAKQDPE-----AVTPLDHLV----------PVVLGPMGLKSKEQKVVKLDPSQPALGNLTPVVLGPEELW------------------------- T_guttata_ENSTGUP00000017449 ILRDTGQGHLAEMLMQEC-----ESRPVPPQLP---DLRPVELEL--------------------------------------------------------------------------- O_anatinus_ENSOANP00000015596 CLRETDQHALAALLSEGC-----QAPQVTPV-----DIRPVEIIR--------------PGGQGDVCKYSKIHPKCYSPPLPFQSTSPLRGKEQW------------------------- G_gallus_ENSGALP00000002083 ILRDTGHGDLADMLDEGC-----GSPMSPPV-----DLRPVQLEL--------------------------------------------------------------------------- T_guttata_ENSTGUP00000010628 LLEKQGLLTTDNVKILED-----VCMTVSPD-----LLETINCYK------------KGK------------------------------------------------------------ C_intestinalis_ENSCINP00000024485 CMEEEDLLSEGDLDFIMS-----ILQHLDNQ-----KPYKLFQRV----------------------------------------RMNDNTVTLPKNQQKSNAFQPNSHLPVASGFNSLS C_elegans_C48D1.2 ALRSTGHEGLAEVLEPLA-----RSVDSNAV-----EFECPMSPASHRRSRALSPAGYTSPTRVHRDSVSSVSSFTSYQDIYSRARSRSRSRALHSSDRHNYSSPPVNAFPSQPSSANSS C_intestinalis_ENSCINP00000028692 EIKTELDLNLDFSRSDAT-----DAGGFDPG-----SEGTITEIG--------------------------------------------------------------------------- T_rubripes_ENSTRUP00000024467 EMEKKGLLSNTKLDKLHS-----VLKEVDQR-----LAATVHDFM--------------------------------------------------------------QPLRGILVPRGPG M_mulatta_ENSMMUP00000040583 CLVDTGQDMLASFLRTNR-----QAVKL------------------------------------------------SKPTLENLTPVVLRPE---------------------------- R_norvegicus_ENSRNOP00000040783 -----MENNKTLVDSKS------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000023986 CLEDTGQDALASCLTMSR-----QAVKQNPE-----ATRPLD-LM----------PVVLGPTRLTPEDLR--GKDPSKLTPGKLAPVVLGPA---------------------------- E_caballus_ENSECAP00000015102 CLEDTGQDTLASFLRTSS-----QAAKQNPE-----AIRPSD-LP----------PVVLGPVGLKPEELTAVKQDPSKLTPGKLTPVVLGPEELW------------------------- D_rerio_ENSDARP00000047019 SLRETGHNDLAELLQSGDGVHRPPVISVQPSP----IPLPVQNLN-----------HTEKPDKPDIASPRLVP----------------------------------------------- P_troglodytes_ENSPTRP00000056642 CLEDTGQDMLASFLRTNR-----QAAKL------------------------------------------------SKPTLENLTPVVLRPE---------------------------- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0082755 ------------------------IAHTPTSELDLKR--III----SRP--TNEDTYE-NCARAGIALILNHKDVK----------GQKQRVGTERDRDD-MEATLQGFGFD-VRTFDDL A_aegypti_AAEL003444-PA -----------------------FGSRTNESSKSIKE--ALV----SRA--ALDEYYDTTNKRRGIALVFCHMNFS----------VMAKRNGADKDRDD-ICNTLYGLDFD-VRVFDDL A_gambiae_AGAP011951-PA ------------------------------------------------------ECYDTSNARRGIALIINQVIFS----------SMAVRVGSSKDRTD-ISTVLQRIGFE-VRVMDDP A_gambiae_AGAP011952-PA ------------------------------------------------------ENYDTSHRNRGTALIFNHVNFE----------SNAKREGSNKDRDE-IKKELLQLGFD-ARVFNDL A_gambiae_AGAP004920-PA -----------------------LVASVPEI-ISSSV--IHE----LEP--VDDAHYNMSHNRRGVAAVFNHRKFL----------HASERKGTDADCDN-IRQVLIYLQFE-VRVYDDL A_gambiae_AGAP004921-PA ------------------------ITQTDQI-ASRQR--SQN----ARA--LQEEEYDTNHRRRGMAIILNHENFE----------LMSKREGTNRDRDA-ATAVLTSMQFD-VRVYNDL A_gambiae_AGAP000830-PA ---------------------RKGHDPTNHLVR---ARMPVE---------RYACDYNMNHKRRGLALIFNHENFD--------VPQLRSRAGTNVDCEN-LTASLKGLDFE-VHVFKDL A_aegypti_AAEL003439-PA -----------------------FGNKTNESSTSNEN--RPL----SRP--TCDEYYDMSNKRRGIALVFCHMNFAV----------MAKRNGTDKDRDD-ICSTLSGLDFD-VRVFNDL A_gambiae_AGAP011949-PA ---------------------------------------MDS----ILE--FELKSYDTTHPNRGIAVVINDS---------------ERREGSEKDVQD-VVATLEGLKFN-VRTFQDN M_domestica_ENSMODP00000005556 ---------------TKNSG---VKLFHGSKSVESGL---------------SSDSYKMDYPEMGLCIIINNKNFH-------PNTGMSFRSGTDVDAAS-LSDTFRSLKYE-VRIKNDL X_tropicalis_ENSXETP00000003217 --------------YFTNQQISLQNCDIKDMEKKTKF--------------AHLHKYRTDYPEMGICLIINNKNFQ-------SSTNMGVRNGTDVDARK-LHETFTGLGYK-VKVCNDQ A_carolinensis_ENSACAP00000009923 ----------------------------------------------------PTFRYRMDYKKLGKCVIINNKNFA-------KDTGMRIRNGTDKDAGD-LQKCFRGIGFD-VSIYNDL A_carolinensis_ENSACAP00000002670 --------------------------IPVSKSVDSVI--------------EADESYRMDHPEMGLCILVNNKNFH-------PATGMSYRSGTDRDAAH-VVDTFRTLGYM-VKPYNDL P_troglodytes_ENSPTRP00000005216 ---DRSSFVPSLFS-KKKKNVTM-----RSIKTTRDR--------------VPTYQYNMNFEKLGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFRSLGFD-VIVYNDC H_sapiens_ENSP00000358327 ---DRSSFVPSLFS-KKKKNVTM-----RSIKTTRDR--------------VPTYQYNMNFEKLGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFRSLGFD-VIVYNDC D_melanogaster_FBpp0071971 TPESLVVGGATA-------------ASPLPA-NKFVARMPVE---------RYASEYNMSHKHRGVALIFNHEFFD--------IPSLKSRTGTNVDAQE-LKKAFENLGFA-VSVHKDC O_cuniculus_ENSOCUP00000009498 ---DRSSFVPALFS-KKKKNGPK-----QSAKATRDQ--------------VPSYQYNMNFDKMGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFRSLGFD-VMVYNDC G_gallus_ENSGALP00000014503 ----------------KKKNGEEEQPKSSLSNQYRIV--------------TPTFQYNMNYKKVGKCIIINNKNFE-------DKTGMGTRNGTDKDAGD-LSKSFRSLGFD-VYTYNDR O_anatinus_ENSOANP00000000517 ---------------FHSSQGYSSRKVPGKQFLGSSA--------------SLDDRYRMDYPNMGICLIINNKNFH-------PDTRMGCRSGTDVDAAS-LRDTFKKLKYE-VRCKNDL M_mulatta_ENSMMUP00000001627 -------------S-KKKKNVSG-----QSIKTTRDR--------------VPTYQYNMNFEKMGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFQSLGFD-VIVHNDC P_pygmaeus_ENSPPYP00000003106 ---DRSSFVPFLFS-MKKKNVSM-----QSIKTTRDR--------------VPTYQYNMNFEKLGKCIIINNKNFD-------KVTGMGVRNGTDKDAEA-LFKCFRSLGFD-VIVYNDC R_norvegicus_ENSRNOP00000022693 ---DRSTIISSLLW-KKKKNASM-----CPVSTTRDR--------------VPTYLYRMDFEKMGKCIIINNKNFD-------KATGMDVRNGTDKDAEA-LFKCFRSLGFE-VTVYNDC G_gallus_ENSGALP00000017288 ---------------FPGSK---GMNLPASKSVDSGI--------------LPDDSYRMDYPEIGVCVIINNKNFH-------RDTGLSSRSGTDADAAS-VREVFMKLGYK-VKLNNDL B_taurus_ENSBTAP00000008706 -------------S-KKKKNDSG-----KSVNIPRDR--------------VPTYQYNMNFEKVGKCIIINNKNFD-------RITGMGVRNGTDKDAEA-LFKCFRSLGFD-VSVYNDC A_gambiae_AGAP011950-PA ---------------------------------------MDS----LLE--LELQSYKTNHPNRGIAVVINDS---------------ENRDGWEKDLEA-VETVLQRLKCD-VRTFCDK E_caballus_ENSECAP00000013731 ---DRSSFVPSLFS-KKKKNGPE-----RSITTNRNR--------------EPTYQYNMNFEKVGKCVIINNKNFD-------RGTGMGVRNGTDKDAEA-LFKCFRNLGFD-VVVYNDC P_pygmaeus_ENSPPYP00000017020 ---------------IKNLE---PKVIHGSKSMDSGI--------------SLDNSYKMDYPEMGLCIIINNKNFH-------KSTGMASRSGTDVDAAN-LRETFRNLKYE-VRNKNDL T_nigroviridis_ENSTNIP00000022078 ---DRRGRFLLFKS-KKKNDGQMREQDYCSESHYRIV--------------SPTFQYRMSHQRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGE-LYKCFKSLGFD-VFIYNDQ D_melanogaster_FBpp0084848 GSSGLVAGSSHPYGSGAIGQLANGYSSPSSSYRKNVAKMVTD---------RHAAEYNMRHKNRGMALIFNHEHFE--------VPTLKSRAGTNVDCEN-LTRVLKQLDFE-VTVYKDC P_troglodytes_ENSPTRP00000054330 ---------------IKNLE---PKIIHGSQSMDSGI--------------SLDNSYKMDYPEMGLCIIINNKNFH-------KSTGMTSRSGTDVDAAN-LRETFRNLKYE-VRNKNDL H_sapiens_ENSP00000311032 ---------------IKNLE---PKIIHGSESMDSGI--------------SLDNSYKMDYPEMGLCIIINNKNFH-------KSTGMTSRSGTDVDAAN-LRETFRNLKYE-VRNKNDL X_tropicalis_ENSXETP00000035938 --------------STKKKKTEDPEKPPQASDNVRIV--------------TPAFQYKMNYGKVGRCIIINNKNFD-------DITGMSPRNGTDIDARD-LLRCFKGLGFD-VTVFNNK G_gorilla_ENSGGOP00000007184 ---XXXXXXXXXXX-XXXXXXXX-----XXXXXXXXX--------------XXXXXXXXXXXXXXXXXXXXXXXFD-------KVTGMGVRNGTDKDAEA-LFKCFRSLGFD-VIVYNDC T_guttata_ENSTGUP00000006879 ---------------IPGFK---GKNLPASKSMDSGI--------------LPDYSYRMDYPEMGECIIINNKNFH-------RYTGMSPRSGTDADAAS-VREVFMKLGYK-IKINNDL G_aculeatus_ENSGACP00000008661 ---DRRGRFLLFGNIKKNKDGQTREQDYSSESHYRVV--------------SPTFQYKMSHQRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGE-LFKCFKSLGFD-VFIYNDQ C_familiaris_ENSCAFP00000016420 ---DRSSFVPSLFS-RKKKNDSG-----RSIKTAQDQ--------------VPTYQYNMNFEKVGKCIIINNKNFD-------KTTGMGVRNGTDKDAEA-LFKCFRNLGFD-VVIYNDC M_musculus_ENSMUSP00000026062 ---DRSSIISSILL-KKKRNASA-----GPVRTGRDR--------------VPTYLYRMDFQKMGKCIIINNKNFD-------KATGMDVRNGTDKDAGA-LFKCFQNLGFE-VTVHNDC M_musculus_ENSMUSP00000091238 ---------------INNFE---VKTIHGSKSVDSGI--------------YLDSSYKMDYPEMGICIIINNKNFH-------KSTGMSSRSGTDVDAAN-LRETFMGLKYQ-VRNKNDL A_gambiae_AGAP012945-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015808 ---------------IKSLE---PKIIHGSKSVDSGI--------------SLENSYKMDYPEMGLCIIINNKNFH-------KSTGMASRSGTDVDAAN-LRETFINLKYE-VRNKNDL T_rubripes_ENSTRUP00000031759 ---DRKGRFLLFKS-KKNKDGQMREQDYCSESHYRIV--------------SPTFQYKMSHQRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGE-LFKCFKTLGFD-VFIYNDQ B_taurus_ENSBTAP00000021099 ---------------IKTSE---TKILHGSKSMDSGI--------------SLEESYKMDYPEMGLCIIINNKNFH-------ENTGMCRRSPTDDSVAQ-XRETFMNLKYE-VRIKNDL E_caballus_ENSECAP00000019797 ---------------IKNSE---TKILHGSKSMDSGI--------------SLDSSYKMDYPEMGLCIIINNKNFH-------KSTGMASRSGTDVDAAN-LRETFTNLKYE-VRNKNDL D_rerio_ENSDARP00000019984 ---DRKGRFRLFGN-FKKNDGKLQEKG-ESESHYRIV--------------SPTFQYKMSHQRVGKCIIINNKNFD-------EKTGMNVRNGTDRDAGE-LFKCFKSLGFD-VAVYNDQ C_familiaris_ENSCAFP00000032189 ---------------FKNAE---TVIV---KILKDKY--------------LTKLHYKMDYPEMGLCIIINNKNFH-------KSTGMAPRSGTDVDAAN-LRETFTNLKYE-VRNKNDL A_gambiae_AGAP009832-PA ------------------MPHGSPIASGSQTANGIIR--PAY----VIE--RYAAYYPMNHKRRGMALIFSHNKYNV------RNVSLPVREGSAIDCKR-LKETLELFRFD-VKVYPDF T_guttata_ENSTGUP00000011206 ----------------KKKNGEEEQPKPSLSNQYRIV--------------TPTFQYNMDYKKVGKCIIINNKNFE-------DKTGMGTRNGTDKDAGD-LAKSFKNLGFE-VDIHHDR M_domestica_ENSMODP00000005560 ---------------IKNSG---VKSLHSSKSVESGL---------------SSDSYKMDYPEMGLCVIINNTHFH-------NDTELSPRTGSDKDAAN-LIDIFRSLKYE-VRNKNNL O_anatinus_ENSOANP00000002508 ---ERLK-VAQLFS-KKKNEAESQSGG-PLPVRNRVV--------------SSSFIYNMKYENLGKCIIINNKNFA-------SKTGMSTRNGTDKDAGN-LQKCFRSLGFD-VSVFNDF R_norvegicus_ENSRNOP00000014096 ---------------INNFE---TKTIHGSKSMDSGI--------------YLDSSYKMDYPEMGLCIIINNKNFH-------KSTGMSARNGTDVDAAN-LRETFMALKYE-VRNKNDL T_guttata_ENSTGUP00000004278 ------------------------------I-RQSLD--P-------------AEEYKMNHQRRGLALIFNHERFY-------WHLRLQDRRGTWVDRNN-LKSILTELGFE-VRLFDDL G_aculeatus_ENSGACP00000023055 --------------------------------RSSLD--P-------------AEEYKMDNKRRGLALIFNQERFF-------WRLGLNDRHGTNADRYN-LERRLSNLNFD-VRAYDNL D_rerio_ENSDARP00000071815 ------------SDAKESSSVTDPGLVQMDAKSHSDD--------------NVDYQYKTNYPNLGQCLIINNKNFH-------KRTGMGVRNGTDEDAKK-VFETFSQLGFK-VGHYNDL A_carolinensis_ENSACAP00000012644 ------------------------------R-NHLFD--P-------------AAEYKMSHKRRGLALIFNHEHFF-------WHLMLPERRGTQADKEN-LKRGLTDLGFE-VKCFDDL G_gallus_ENSGALP00000019870 ------------------------------K-RQTFD--P-------------AVQYKMNHQRRGVALIFNHEHFF-------WHLRLPDRRGTLADRNN-LKRSLTDLGFE-VRIFDDL A_gambiae_AGAP012544-PA ---------------------------------------MDS----TLQ--LTLHSYNMAHPKRGIAVVINNN---------------RDRKGSEKDVKA-LQAVLSHLQFD-VRLLSDK T_nigroviridis_ENSTNIP00000009934 -------------GGEQPSGSSSS---GKMTVDAKSA--------------RYSFRYSLDFPNLGHCIIINNKNFD-------RRTGMNTRNGTDVDAAN-AMKVFSNLGYR-VRVHNDQ O_latipes_ENSORLP00000010095 --------------DNGELAAGASPAPDRMDVDGKPS--------------SHSFRYSLNFPTIGLCIIINNKNFD-------RGTGMNQRNGTDIDAAS-AMKVFSKLGYR-VKIYNDQ C_intestinalis_ENSCINP00000003204 -------------------------SGETPRIYSLPD--VTK----MAS--SEVECYQMDRESRGLALIINNENFH-------HATRMNKRSGTDVDARN-LSRIFKKLGFD-VQVYKDL D_rerio_ENSDARP00000093958 ----------------------------------------------------------MKHAKRGLALIFNQKDFS-------L-LGLKTRKGTDKDRDS-LVSRFEELDFE-VKAYNDY A_aegypti_AAEL014348-PA ---------------MKKIMFGRKEVNSPQQMIPTVA--PAY----TIE--RYSAYYPMNHKHRGKAIIFAHSVFAV------KNVNLPNRDGSDVDCEM-LVESLKRLHFD-VTLYKDY O_anatinus_ENSOANP00000005811 ------------------------------D-RETFD--P-------------AAKYKMEYKRRGVALIFNHERFY-------WQLKLPDRHGTRADREN-LIRRLSALGFE-VKCFDDL M_domestica_ENSMODP00000007353 ------------------------------K-SKPLD--P-------------AEQYKMDHKRRGVALIFNHERFF-------WHLTLPERRGTRADRDN-LRQRLSDLGFE-VNCFDDL C_intestinalis_ENSCINP00000011493 ----------DYGSDAGPDNSDTGPPLPYKQKSKVIE--PEA----IAV--NREFQYPMNHKQRGCCIIFNQKHFD-------AHLRMDTREGTNHDAEN-IKHSMEMLGFEHVRIIKDS D_rerio_ENSDARP00000006831 ----------VDTTDASKDGASAS---QPMQVDAKPQ--------------SHAFRYSLNYPNIGHCIIINNKNFD-------RRTGMNPRNGTDVDAGN-VMNVFRKLGYI-VKVYNDQ D_rerio_ENSDARP00000041413 -----------------------------------------------------------------MALIFNQKQFD-------WKLGLKTRNGTDKDRDDLVSRRFQELNFE-VKAYNDY M_musculus_ENSMUSP00000029626 ------------------------------KSREVFD--P-------------AEQYKMDHKRRGVALIFNHERFF-------WHLTLPERRGTNADRDN-LTRRFSDLGFE-VKCFNDL X_tropicalis_ENSXETP00000052017 ------------------------------SRTLELD--P-------------SAEYKMTHKRRGLALIFNHEDFY-------WQLRLGSRRGTNTDSMN-LNRILTDLGFD-VQNYYNL R_norvegicus_ENSRNOP00000013049 ------------------------------RSREVLD--P-------------AEQYKMDHKRRGTALIFNHERFF-------WHLALPERRGTNADRDN-LTRRFSELGFE-VKCFNDL D_rerio_ENSDARP00000050929 ------------------------------QSIFSMD--P-------------NQEYDMNHKRRGMALIFNHENFF-------WKLGLGYRSGTNADKEN-LIRRFRELNFE-VKAFDDY T_rubripes_ENSTRUP00000022652 ------------------------------GSIGFLD--P-------------AEEYKMDNKRRGLALIFNQERFF-------WRLGLRDRHGTNADSYN-LQRRLKELNFE-VKVFDNH H_sapiens_ENSP00000265164 ------------------------------K-REMFD--P-------------AEKYKMDHRRRGIALIFNHERFF-------WHLTLPERRGTCADRDN-LTRRFSDLGFE-VKCFNDL T_rubripes_ENSTRUP00000040691 ------------GAGQQPRSGSSS---GRVTVDAKPA--------------AYSFRYSLDFPNMGHCIIINNKNFD-------RRTGMNTRNGTDVDAAN-AMKVFLSLGYK-VKVHNDQ P_pygmaeus_ENSPPYP00000016744 ------------------------------K-REMFD--P-------------AEKYKMDHRRRGIALIFNHERFF-------WHLTLPERRGTCADRDN-LTRRFSDLGFE-VKCFNDL A_gambiae_AGAP004922-PA ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013268 ------------------------------K-REMFD--P-------------AEKYKMDHKRRGIALIFNHERFF-------WHLTLPDRRGTSADRDN-LMRRFSDLGFE-VKCFNDL G_aculeatus_ENSGACP00000022402 --------------EQSEVSSSAS---APEEVDAKPN--------------VHSFRYSLSFPSIGQCIIINNKNFD-------RGTGMNQRNGTDVDAAN-AMKVFGNLGYK-VKVYNDQ D_rerio_ENSDARP00000072390 -----------------------------------------------------AFEPYKKHKNIGKCLIISNEHFP-------VQFSLNRKKGNSVDERR-LSSTFKSLGFH-VKVENNL G_aculeatus_ENSGACP00000024812 ----------------------------------------------------DKYRYKMDYPCMGTCVIINNKTFD-------PKTGLSPRNGTDVDAAE-LEKTFSRLGYK-VTVANDQ B_taurus_ENSBTAP00000016642 ------------------------------R-REIFD--P-------------TEKYKMDHKRRGIALIFNHERFF-------WHLTLPNRPGTSADRDN-LRRRFSDLGFE-VKCFDDL T_nigroviridis_ENSTNIP00000021186 ------------------------------GRNSIVD--P-------------AEEYKMDNKRRGLAIIFNQESFF-------WRLGLKDRHGTNADSYN-LQRRLRELNFD-VNVYNNY P_troglodytes_ENSPTRP00000028104 ------------------------------K-REMFD--P-------------AEKYKMDHRRRGIALIFNHERFF-------WHLTLPERRGTCADRDN-LTRRFSDLGFE-VKCFNDL A_aegypti_AAEL012143-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 -------------VISKRSPANQPNPRSTDVCVIKQD--------------ADPYRYSMDYPKMGICLIINNKNFH-------KDSGMGPRNGTDNDAAA-AWKSFMKLGYE-IQMYNDQ G_aculeatus_ENSGACP00000024816 ---------------------------------------------------------------------------------------MSPRNGTDVDAAD-AFRTFSKLGYK-VTVANDQ O_anatinus_ENSOANP00000005531 --------------------------------------------------------YRMNRAHRGYCIIFNNYTFKG---------KLNSRKGTQKDVAE-LERVFRWLGLD-VETFNDK C_familiaris_ENSCAFP00000016791 ------------------------------K-REMFD--P-------------EEKYKMDHKRRGIALIFNHERFF-------WHLTLPDRRGTSADRDN-LVRRFSELGFE-VKCFNDL G_gallus_ENSGALP00000013591 ---------------------------------------------------SQLEVYKMTSRPRGVCLILNNHNFAKAREAVPELRRMKDRNGTHVDADA-LRKVFSNLHFT-VAEYKDC T_nigroviridis_ENSTNIP00000001216 ENQSSSRTEASVMSSANAVGIKPGTLMLGLS-PPPVG--SPN----FPV--QDLGTYPMTTLPRGCCLIISNYDFQGS--------GLGMRNGTRTDEEC-LKKVFEWLGFK-VEIHRDC C_familiaris_ENSCAFP00000017933 -P-LKHRAKQGNIISDGA-TLVSVEMLEAST-GPLTS--ET------ST--KEANVYRMDRKHRGHCVIVNNHTFAK----------MPDRPGTDKDAEC-LSRVFQWLGFS-VHVYKNV M_mulatta_ENSMMUP00000037892 ---------------------------------------------------TLDKVYQMKSKPRGYCLIINNYDFTKAREKVPKLHSIRDRNGTHLDAEA-LTATFEELHFE-IQHHNDC G_gallus_ENSGALP00000013506 -LRNKKYSVTGASAACHAISMPSTGVQNALA-NTTVC--YS------SF--LQVSSYKMDGPRRGICLVINNVKFDG---------VLQERKGSYKDACE-LERVFTWLGLD-VRTYTDQ C_intestinalis_ENSCINP00000025743 -------------------------------------------------------KYKMNHKERGCFMIFNQEVYDAK-----TSLNLGERIGSSTDARN-LASAAAYLGFEYIQVFNNL G_aculeatus_ENSGACP00000005791 DCAALSLGLSGHLKIEVVETMPPPKNMSCSE-PPTSQ--PSD----TNT--EVLGTYPMTSAKRGICLIVNNFDFTK-------FKNYQNREGTMKDEER-LHKVFAWLGFE-VEVKHDC A_carolinensis_ENSACAP00000001629 ---------------------------------------------------QASTCYKMDGLNRGSCLIFNNVHFEG---------GLSQRRGSQKDAEE-LESVFRWLGLD-VIKYNDT D_rerio_ENSDARP00000075318 -----------------LLVPVPETELTPSQLSETTG--CST----DKT--NTMNEYEMKSNPRGLCLIFNNENFKDP---------DMKRHGSQMDTAS-LKDLFEWLGFS-VEIKQDQ M_domestica_ENSMODP00000036247 ---------------------------------------------------EKGNVYKMSSRPRGYCLIINNFDFKISRKERPENHYLTDRRGTNKDEEA-LKNIFKELHFD-IQSFQDL P_troglodytes_ENSPTRP00000021879 ---------------------------------------------------TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGA-LTTTFEELHFE-IKPHDDC C_intestinalis_ENSCINP00000011503 --------------------DSSDDFYKDDDDDGKGL--VPT----VLR--QHMLEYYMKNERRGTFVVFNQENFDR---------MRHPRKGSGVDVEM-LVKSANKLGFEDVRVLKNQ H_sapiens_ENSP00000351273 ---------------------------------------------------TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGA-LTTTFEELHFE-IKPHDDC D_rerio_ENSDARP00000075645 -----------------------PLQSTCNISDHYPK--RKR----AVT--EQKEWYSMSNRPLGYCLIINNYKFE--------SASLADRRGTDRDKDD-LTKVFEKMYFK-VEVRDDL M_musculus_ENSMUSP00000027189 ---------------------------------------------------TSDKVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEA-LSKTFKELHFE-IVSYDDC R_norvegicus_ENSRNOP00000016613 ---------------------------------------------------NSDNVYQMKSKPRGYCLIFNNNNFSKAREDIPKLSNMRDRKGTNYDEEA-LSKTFKELHFE-IVSFSDC P_pygmaeus_ENSPPYP00000014606 ---------------------------------------------------TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGA-LTTTFEELHFE-IKPHNDC D_rerio_ENSDARP00000063081 ---------------------------------------IFA----SSV--QKVSQYKITQNPRGICVIINNVDFT----------SMGERRGSDEDQNY-LAKVFRWLGFE-VVAHRNK G_aculeatus_ENSGACP00000024809 --------------------------MDKLYRDVQSG--------------EDKYRYKMDYPCMGTCVIINIKNFD-------LKTGLETRNGTDVDAAE-LEKTFSKLGYK-VTLVHDQ H_sapiens_ENSP00000286186 -Q-NKHAGSNGNRATNGAPSLVSRGMQGASA-NTLNS--ET------ST--KRAAVYRMNRNHRGLCVIVNNHSFTS----------LKDRQGTHKDAEI-LSHVFQWLGFT-VHIHNNV D_rerio_ENSDARP00000075650 ---------------------------------------IFD----SSV--QEISPYRIIKNPRGICVIINNEIFS---------SGMMSRRGSDKDREY-LAKVFHWLGFE-VVEHNNK O_anatinus_ENSOANP00000006351 ---------------------------------------------------QNGDFYKMNSNPRGYCLIINNYNFQQARAEVPKLKKMKNRDGTDKDAEA-LSQIFKALAFS-PVVFEDQ T_guttata_ENSTGUP00000010625 ---------------------------------------------------QLLEAYKMTSRPCGVCLILNNHNFAKAREGVLEHKHMKDRNGTDVDAAA-LRNVFSKLHFR-VEEYRDL E_caballus_ENSECAP00000004055 ---------------------------------------------------TSDKVYRMESKPRGYCLIFNNHDFSAARRDVPKLQNIKDRNGTDLDAEA-LSMTFTELHFE-VVPYKNS O_cuniculus_ENSOCUP00000006164 ---------------------------------------------------TSEEVYQMKSKPRGYCLIVNNYDFSIARREMPRHRNMKDRKGTEVDAEA-LSNTFTDLHFE-VVHYNDC T_rubripes_ENSTRUP00000044662 -NRCPLLTAASLLEQS-----------CSFN-TLQVG--CPD----VSV--QGVETYLMTAAKRGRCLIINNCNFRVS--------RLKKREGTMVDEAS-LDKVLKWLGFE-VEIQRDC C_familiaris_ENSCAFP00000017899 ---------------------------------------------------TSDKVYRMKSKPRGYCLIFNNYDFSVARREVPKLQSIKDRNGTDLDADA-LSKTFSELHFE-IVHFKDA P_pygmaeus_ENSPPYP00000014602 -Q-NKHAGSNGNRATNGAPSLVSRGMQGASA-NTLNS--ET------GT--KGRKGYRMNRNHRGLC-LLNNHSFTS----------LKDRRGTHKDAEI-LSHVFQWLGFT-VHIHNNV M_mulatta_ENSMMUP00000037898 -----------------------------------------------FF--KRAPTYRMDRNHRGLCVIVNNHSFIS----------LRDRRGTHKDAEI-LKGVFQWLGFT-VHIYNNV D_rerio_ENSDARP00000024255 ------------------------------------------------------EQYEMKGERRGVCLIINNYDFSAC--------GWLNREGTDIDHDS-LRDVFEWLGFE-ILTRRDC M_musculus_ENSMUSP00000030747 --------PARLKPEVLRPETPRPVDIGSGGAHDVCV--PGK----IRG--HADMAYTLDSDPCGHCLIINNVNFC-------PSSGLGTRTGSNLDRDK-LEHRFRWLRFM-VEVKNDL E_caballus_ENSECAP00000021726 -P-WEHTHAGLGSLPLGN-SRVSKGWSSALA-SGIGS--IS------SS--KETPLYRMDRTHRGHCVVVNNHTFTS----------LADRPGTDKDAEC-LKSVFQWLGFS-VHRYDNV G_gorilla_ENSGGOP00000000205 ---------------------------------------------------TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGA-LTTTFEELHFE-IKPHDDC X_tropicalis_ENSXETP00000008971 --------TGMIHEEAEKEDDKSGNINHQLSDLRLNS--EMT----PQA--NKEEFYDMNHKHRGYCLIIDNSVFM----------KGNRREGSDKDAGA-LSDVFSWLGLE-VDIFENL T_rubripes_ENSTRUP00000045375 ----------RDKAPVIPVPQPSTAPSPSPEREYMRLKPQGR----IRR--DSIQSYKMDANPSGHCLIINNVDFE-------PRSELNDRKGSNTDCDR-LESRFKALNFI-VKVKTNL P_troglodytes_ENSPTRP00000048878 -Q-NKHAGSNGNRATNGAPSLVSRGMQGASA-NTLNS--ET------ST--KRATVYRMNRNHRGLCVIVNNHSFTS----------LKDRQGTHKDAEI-LSHVFQWLGFT-VHIHNNV M_domestica_ENSMODP00000005512 ---------------------------------------------------------------------------------------------------------------------NDL O_cuniculus_ENSOCUP00000011835 ------------------------------K-REVFD--P-------------AEEYKMDHRRRGIALIFNHERFF-------WHLMLPERRGTNADRDS-LARRFSDLGFE-VKCFNDL T_guttata_ENSTGUP00000014729 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000004412 ----------PLELIKRQPTFSKVLSLLYKLRFPFCP--PP----------QVGQVYTLNSDPCGYCLIINNVDFC-------ASSGLSSRKGSNIDCEK-MHNRFQALHFA-VEVERNL B_taurus_ENSBTAP00000038128 ---------------------------------------------------TSDTVYRMTSKPRGYCLIFNNYDFSIARKQVPELHDLKDRTGTDFDADA-LDKTFRELHFE-IVHYKDL G_gallus_ENSGALP00000013571 --------------------------------SAGIF--PPH----VQI--LLVESYKMENNPHGYCVILNNYRFKNP---------NETRKGTVEDGKA-LKRVFKWLQFD-TIEYMDL B_taurus_ENSBTAP00000003205 --------PAKLRPEVLRPEVPRAVDAGSGGFTDVCP--QDR----AKG--NADLAYVLNADPCGHCLIINNVNFC-------RESGLRARTGSNIDCER-MRQRFHLLQFV-VEVKCDL T_nigroviridis_ENSTNIP00000013855 ------------EEPVSPVPKPSTPGRASPEVEYVTL--KGR----IRR--DSLQSYRMEANPLGHCLIINNVEFE-------PKSGLSNRNGSNVDCDR-LERRFKALNFT-VKVKTNL O_cuniculus_ENSOCUP00000003895 ------------------PALASVELLRAPA-DFLRL--ET------ST--REANVYRMDRKHRGRCVIVNNEIFTT---------YLSDRRGTQRDAE--QKLVFQWLGFK-VHKCDNK M_domestica_ENSMODP00000036251 ----KHLPFSQQNEANNSLEEVTGLWAQGAE-GGTLF--SD------MT--NEAKFYRMDHSHRGHCIIFNNFEFQT----------MKRRRGSCKDADE-LKSVFEWLGFT-VKIHPNT O_latipes_ENSORLP00000005993 ----------------------------------------------------------MSHQRVGKCIIINNKNFD-------DNTGMNVRNGTDRDAGE-LYKCFKSLGFD-VSIYNDQ G_aculeatus_ENSGACP00000007379 ----------------------CDAHVTAPERENTLTRPPGR----TRR--DSIQSYKMDASPCGHCLIINNVEFE-------PDSELSNRKGSNIDCDK-LEKRFKALNFI-VEVRTNL R_norvegicus_ENSRNOP00000017972 --------PTRLRPEVLTPETPRPVDIGSGRAHDVCT--PGK----IER--HADMAYTLDSDPCGHCLIINNVNFC-------PSSGLSTRIGSHVDCEK-LQHRFCWLRFM-VEVKNDL T_guttata_ENSTGUP00000017449 ---------QEANQRCAVVLQTAARDVAAGIPLTVGK--SPE----VMS--FIILDYEMKADPCGHCLILNNVNFC-------RDSGLSTREGSDIDCEK-LERRFKALCFT-VLTRRDL O_anatinus_ENSOANP00000015596 --------TGSVKPFVPVPSTTK-------REQEATR--PGE----KQG--MAIKVYSLKSEPCGHCLIINNVDFS-------LGSGLSTRTGSDVDCEK-MKRRFRLLHFE-VAVERNL G_gallus_ENSGALP00000002083 -PGERRDKSVSTAERLSIPVQPESERFRMPPAPAQAC--PTG----LAG--ECSEVYQLRADPCGHCLIFNNVSFS-------RDSDLSTRAGSDIDCEK-LEKRFRSLCFH-VRTLRNL T_guttata_ENSTGUP00000010628 ---------------------------------------------------GEKFIISLHGDFIKSFPLASNFPFIF-----------------HLFTEQ-LERVFTWLGLD-VMTSTDL C_intestinalis_ENSCINP00000024485 KQEYNHTSKLEPQYVSMENHRAFNGGYNQYNNYQSEI--KDT----STM--GILDKYPM--ERRGYCLIINNENFE-----------RQDRTGSGNDTER-LENLFKEFGFI-LDVRKDL C_elegans_C48D1.2 FTGCSSLGYSSSRNRSFSKASGPTQYIFHEEDMNFVD--APT----ISRVFDEKTMYRNFSSPRGMCLIINNEHFE----------QMPTRNGTKADKDN-LTNLFRCMGYT-VICKDNL C_intestinalis_ENSCINP00000028692 ----------------------DTDQNETIK-RGFIS--LDE----LGE--NFDFCYNMQHKKRGLFVVFNQMKFD-------KHLKLSERTGSDKDAAA-LLKTAELLGFE-TEEYLDL T_rubripes_ENSTRUP00000024467 TPPPAVMSMVIPVRLAVPETQSRGTEQNVSPDAESIF--QSS----PPA--DDNEYYALIHNPRGLCVVFNNETFL-------PGANLPRRGGTMEDQKR-LRSVFTKFGFT-VQVHNDF M_mulatta_ENSMMUP00000040583 ----------IRKPEVLRPETPRPVDIGSGGCGDVGA--PES----LRG--NADLAYVLSMEPCGHCLIINNVNFC-------RESGLSTRTGSSIDCEK-LQRRFSLLHFM-VEVKHDL R_norvegicus_ENSRNOP00000040783 ---------------INYFE----VKTHRSKPMDSGV--------------DLNSSYKMGYSKMGLCIIINNKNLL--------KTEMTSRSGTDVAAANRMSETFMVLKYK-VRNKNDL C_familiaris_ENSCAFP00000023986 ----------ELQPQVVRPSVPRPTDNGSGRFSDVCE--YQESGWWVAG--PIKLAYALNADPCGYCLIINNVNFC-------PESRLTARGGSNIDCEK-LQRRFCLLRFT-VEVKWDL E_caballus_ENSECAP00000015102 --------LAKLRPEVLRPEVPRPVDIGSGGFSDVRA--QDR----LRG--NADLAYVLNADPCGHCLIINNVNFY-------LASGLGRRVGSDIDCEK-LRQRFSLLHFM-VEVKGDL D_rerio_ENSDARP00000047019 ----------------LRPESLPVHKTYSPPSETVVR--PTR----PRR--DSIQCYKMDASPCGVCLIINNINFE-------KASELNDRKGSNIDCDK-LEKRFKALNFE-VTVKRNL P_troglodytes_ENSPTRP00000056642 ----------IRKPEVLRPETPRPVDIGSGGFGDVGA--LES----LRG--NADLAYILSMEPCGHCLIINNVNFC-------RESGLRTRTGSNIDCEK-LRRRFSSLHFM-VEVKGDL 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0082755 TFSEINDTLKEVARE-DHSQNDCFVLAVMSHGTE-------GK-VYAKDM-SYPVERLWNPFLGDNCKTLKNKPKLFFIQ--ACR----GANL-EKAV----EF-----SSF-AVMTREL A_aegypti_AAEL003444-PA SRKEVLDRLKDVSRE-DHSDNDCLVVVMMSHGEQ-------GV-LYARDN-KYNVDSLWKNFVGNACPSLIGKPKMFFIQ--ACR----GEQF-DEGV----AY-----AAK-SPK---- A_gambiae_AGAP011951-PA NRKQLLSALKQLAGE-DHSHSDCLVVVVMTHGKE-------NNLLYASDK-SYEANQLWEPFIGDACPSLIGKPKLFFVQ--ACR----GKKL-DEGV----IQ------AT-ISI---- A_gambiae_AGAP011952-PA KKQELLAKLDEVAKE-DHTESDCFVLVMMTHGQD-------GS-LYAADK-QYQIAELWEPFVGDACKTLIGKPKLFFVQ--ACR----GTKF-DKGV----KL------TK-IAT---- A_gambiae_AGAP004920-PA TRKEIKQVLDDLAEE-DHKNSDCLLVVIMTHGDD-------DV-LHAKDG-TFNVDRLWENFIGDSCPSLLGKPKLFFIQ--ACR----GSSF-DTGV----HF------SQ-CMT---- A_gambiae_AGAP004921-PA GRDELFCVLLALASE-DHSDCDCLLVMLMTHGDD-------DV-LYAYDG-PYSVDKLWESFMGNACTTLLGKPKLFFVQ--ACR----GSTF-DKGV----KL------GC-RDL---- A_gambiae_AGAP000830-PA KLRDLQKEVERVSQM-DHSDADCLLVTILSHGEL-------GY-LYAKDC-QYKLDTIWTYFTANHCPSLAGKPKLFFIQ--ACQ----GDQL-DGGV----VL-----EAK-DRTET-- A_aegypti_AAEL003439-PA RRKELLRTLKNVSRE-DHSENDCLVVVVMSHGDQ-------GV-LYASDK-KYYVDSLWEKFTGNACPSLIGKPKLFFVQ--ASRERQPGKKG-EGGR----EE-----ESQ-ASV---- A_gambiae_AGAP011949-PA TKKEIKKALYKVARE-DHNENDCLVIVAMAHGKK-------DH-ITLKKE-KLRIDKLWASFVGNKCPSLIGKPKLVFIQ--TCR----GDNV-DFGVAS-HET-----DST-PCS---- M_domestica_ENSMODP00000005556 TCNEITELLNSVSKE-DHSQRSSFICVILSHGEE-------GV-IFGTDR-SVELKRLTCFFRGDKCRSLTGKPKLFIIQ--ACR----GTEL-DCGV----ET-----DSG-TD----- X_tropicalis_ENSXETP00000003217 KSNDIFTLLKKMSEE-DHSKRSSFVCAILSHGED-------GL-VYGVDG-PIQIKNLTDLFRGDRCKTLVGKPKLFFIQ--ACR----GTDL-DSGI----ET-----DSG-SE----- A_carolinensis_ENSACAP00000009923 TCDNMEKILGEAALE-NHDDAACFACILLSHGEE-------GL-IYGTDG-CMAIKNLTGLFRGDKCQSLIGKPKLFFIQ--ACR----GSEF-DAGI----QT-----DSG-SSN-DNL A_carolinensis_ENSACAP00000002670 TCKQIVDVLHNVSKD-DHHKRNSFVCVLLSHGED-------GL-IYGTDG-HVELKMLTSFFRGDKCKSLAGKPKLFFIQ--ACR----GTEL-DSGI----ET-----DSA-S------ P_troglodytes_ENSPTRP00000005216 SCAKMQDLLKKASEE-DHTNAACFACILLSHGEE-------NV-IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- H_sapiens_ENSP00000358327 SCAKMQDLLKKASEE-DHTNAACFACILLSHGEE-------NV-IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- D_melanogaster_FBpp0071971 KLRDILKHVGKAAEL-DHTDNDCLAVAILSHGEH-------GY-LYAKDT-QYKLDNIWHYFTATFCPSLAGKPKLFFIQ--ACQ----GDRL-DGGI----TL-----E-K-GVTET-- O_cuniculus_ENSOCUP00000009498 SCARMQDLLKRASEE-DHTNSACFACILLSHGEE-------NL-IYGKDG-VIPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- G_gallus_ENSGALP00000014503 SCEDMQTLLKQAAEE-NHSDAACFACILLSHGEE-------GL-IYGTDG-PMAIKHLTTLFRGDKCKTLIGKPKLFFIQ--ACR----GSEF-DEGI----QT-----DSG-PAN-DTL O_anatinus_ENSOANP00000000517 KRREILELLTSVAHE-DHSKRSSFVCVLLSHGEE-------GV-IFGTDG-SLELKSLASLFRGDNCRSLVGKPKLFIVQ--ACR----GTEL-DSGV----EA-----DSS-SA----- M_mulatta_ENSMMUP00000001627 SCAKMKDLLKKASEE-DHTNAACFACILLSHGEE-------NL-IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- P_pygmaeus_ENSPPYP00000003106 SCAKMQDLLKKASEE-DHTNAACFACILLSHGEE-------NL-IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- R_norvegicus_ENSRNOP00000022693 SCAKMQDLLRRASEE-DHSNSACFACVLLSHGEE-------NL-IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- G_gallus_ENSGALP00000017288 SSRDIFKLLKNVSEE-DHSKRSSFVCVLLSHGDE-------GL-FYGTDG-PLELKVLTSLFRGDKCRSLAGKPKLFFIQ--ACR----GTEL-DSGI----EA-----DSG-P------ B_taurus_ENSBTAP00000008706 SCAKMQDLLKKASEE-DHRNSACFACILLSHGEE-------NL-IYGTDG-KTAIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- A_gambiae_AGAP011950-PA TKHEIRDALRNVSKE-DHTKSDCLVIVAMAHGNN-------DK-ITLRRG-EMHIDELWTDFVGNGCPSLIGKPKLVFIQ--SCR----GNKH-DYLVGG-AAV-----DAV-PSP---- E_caballus_ENSECAP00000013731 SCAKMKSLLKQASEE-DHRNSACFACILLSHGEE-------NL-IYGTDG-MTPIKDLTGHFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PINDD-- P_pygmaeus_ENSPPYP00000017020 TREEIVELMRDVAKE-DHSKRSSFVCVLLSHGEE-------GI-IFGTNG-PVDLRKITNFFRGDRCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-VD----- T_nigroviridis_ENSTNIP00000022078 TCEKMEHLLREASEE-DHSDSSCFACILLSHGEE-------GM-IYGTDG-AMPIKTMTSMFRGDMCKSLVGKPKLFFIQ--ACR----GSEF-DDGI----QT-----DSG-PPN-DTM D_melanogaster_FBpp0084848 RYKDILRTIEYAASQ-NHSDSDCILVAILSHGEM-------GY-IYAKDT-QYKLDNIWSFFTANHCPSLAGKPKLFFIQ--ACQ----GDRL-DGGV----TM-----Q-R-SQTET-- P_troglodytes_ENSPTRP00000054330 TREEIVELMRDVSKE-DHSKRSSFVCVLLSHGEE-------GI-IFGTNG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-VD----- H_sapiens_ENSP00000311032 TREEIVELMRDVSKE-DHSKRSSFVCVLLSHGEE-------GI-IFGTNG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-VD----- X_tropicalis_ENSXETP00000035938 SCTEMETLLRSVAEQ-DHKDSACFACIFLSHGEE-------GL-IYGTDG-AMPIKVLTTLFRGDKCRSLVGKPKLFFIQ--ACR----GCEF-DDGL----ET-----DAG-PSN-DSL G_gorilla_ENSGGOP00000007184 SCAKMQDLLKKASEE-DHTNAACFACILLSHGEE-------NV-IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- T_guttata_ENSTGUP00000006879 SCEGIFNLLKNVSEE-DHSKRSSFVCVLLSHGDE-------GL-IYGTDG-PLELKALTSLFRGDRCRSLAGKPKFFFIQ--ACR----GTEL-DSGI----ET-----DSG-S------ G_aculeatus_ENSGACP00000008661 TCGKMESLLREASEE-DHSDSSCFACILLSHGEE-------GM-IYGTDA-AMPIKSMTSLFRGDMCKSLVGKPKLFFIQ--ACR----GSEF-DDGI----QT-----DSG-PPN-DTL C_familiaris_ENSCAFP00000016420 SCAKMQDLLKKASEE-DHRNSACFACILLSHGEE-------NL-IYGTDG-MTAIKDLTAHFRGDRCRTLLEKPKLFFIQ--ACR----GTEL-DDGV----QA-----DSG-PIN-D-- M_musculus_ENSMUSP00000026062 SCAKMQDLLRKASEE-DHSNSACFACVLLSHGEE-------DL-IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQ--ACR----GTEL-DDGI----QA-----DSG-PIN-D-- M_musculus_ENSMUSP00000091238 TREDILELMDSVSKE-DHSKRSSFVCVILSHGDE-------GV-IYGTNG-PVELKKLTSFFRGDYCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-TD----- A_gambiae_AGAP012945-PA --------------E-DHKNSDCLLVVIMTHGDD-------DV-LHAKDG-TFNVDRLWENFIGDSCPSLLGKPKLFFIQ--ACR----GSSF-DTGV----HF------SQ-CMT---- M_mulatta_ENSMMUP00000015808 TREEIVELMRNVSKE-DHSKRSSFVCVLLSHGEE-------GI-IFGTNG-PLDLKKITSFFRGDCCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-VE----- T_rubripes_ENSTRUP00000031759 TCEKMERLLREASEE-DHSDSSCFACILLSHGEE-------GM-IYGTDG-AMPIKTMTSMFRGDMCKSLVGKPKLFFIQ--ACR----GSEF-DDGI----QT-----DSG-PPN-DTM B_taurus_ENSBTAP00000021099 TCKEMLELMSNVSKE-DHSKRSSFICVLLSHGEE-------GI-IFGTNG-PVNLKKLASFFRGDYCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-AE----- E_caballus_ENSECAP00000019797 TGEEIVALMRSVSKE-DHSKRSSFICVLLSHGEE-------GI-IFGTNG-PIDLKKLTCFFKGDCCRSLAGKPKLFIIQ--ACR----GTEL-DSGI----ET-----DSG-IE----- D_rerio_ENSDARP00000019984 TCRNMERLLKAVSEE-DHSDSSCFACILLSHGEE-------GM-IYGTDG-AMPIKTMTSLFKGDVCKSLVGKPKLFFIQ--ACR----GSEF-DDGV----QT-----DSG-PPN-DTI C_familiaris_ENSCAFP00000032189 TCEEILELMNSVSKE-DHSKRSSFVCVLLSHGDE-------GI-IFGTNG-PVDLRKVTGFFRGDYCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-IE----- A_gambiae_AGAP009832-PA KLEEIKSVIGKVSSM-DHSDSDCFLVAILTHGED-------GGIVYAYDQ-PYELSLIWSFFTADNCPSLAGRPKIFVVQ--ACR----GNQL-DHGV----KV-----QK--------- T_guttata_ENSTGUP00000011206 SRDDMEKLLKKAAEE-NHSDAACFACILLSHGEE-------GL-IYGTDG-PMAIKSLTALFRGDKCKSLIGKPKLFFIQ--ACR----GSEF-DEGI----QT-----DSG-PAN-DTL M_domestica_ENSMODP00000005560 TRDKMIELLRQVSEE-DHSQRSSFVCVILSHGEE-------GV-IFGTDD-SVELKELTYFFKGYKCKSLTGKPKLFIIQ--ACQ----GREF-DCGV----ET-----DSG-TD----- O_anatinus_ENSOANP00000002508 SCNQMKEILQKASEE-NHENSACFACILLSHGEG-------DC-IYGTDD-FIPIKELTILFRGDKCKSLLGKPKLFFIQ--SCR----GTEF-DDGI----QT-----DST-PVT-D-- R_norvegicus_ENSRNOP00000014096 TREEIMELMDSVSKE-DHSKRSSFVCVILSHGDE-------GV-IFGTNG-PVDLKKLTSFFRGDYCRSLTGKPKLFIIQ--ACR----GTEL-DCGI----ET-----DSG-TD----- T_guttata_ENSTGUP00000004278 KKEDVQQRIYEASTA-DHSNADCFVCVFLSHGED-------GH-IFAYDD-KIEIQTITDMFRGDKCQSLVGKPKIFIIQ--ACR----GDKH-DDAV-I--AH-----DSA-DGS--ES G_aculeatus_ENSGACP00000023055 KQEEVLNKINEAAEE-NHSDSDCFLLVFLSHGEN-------DQ-VYTYDG-KISVQDITSLFKGDKCKSLVGKPKIFILQ--ACR----GDKH-DDPV-T--AC-----DAV-DSE---L D_rerio_ENSDARP00000071815 TVSQMMALLNKASQE-DHSKSAMFACVLLSHGDD-------GL-IYGTDN-SIELKRLFAHFRGDRCTSLVGKPKLFFIQ--ACR----GTDL-DSGI----EC-----DGV-------- A_carolinensis_ENSACAP00000012644 KAEEVLQNIYNVSTD-EHDDADCFLCVFLSHGED-------DH-VYAYDA-KIEIKSLTNMFKGDKCPSLVGKPKIFVIQ--ACR----GDKH-DDPV-I--AR-----DTV-DSK-KEL G_gallus_ENSGALP00000019870 KAEDVLKKVFEASRD-DYSNADCFVCVFLSHGEN-------DH-VYAYDA-QIKIETITNMFRGDKCQSLVGKPKIFIIQ--ACR----GDKH-DDPV-L--VQ-----DSV-DSK-DET A_gambiae_AGAP012544-PA TTVEIRHALKEVSKE-DHTNNDCLAIIAMAHGYN-------DR-IKFDDD-YLHIDELWTNFVGNKCPSLIGKPKLVFIQ--SCR----GGKL-DYGASI-ATA-----DAR-PGL---- T_nigroviridis_ENSTNIP00000009934 TVAQISQLLTSAAKE-DHSRCASFVCILLSHGDE-------GV-LYGTDG-PMEIKSLTSLFRGDRCRSLVGKPKLFFIQ--ACR----GNDL-DGGI----ET-----DSI-------- O_latipes_ENSORLP00000010095 TVKQIKQLLTDVSRM-DHSDSASFVCILLSHGDE-------GV-FFGTDG-SIELKTLTSLFRGDHCKSLVGKPKLFFIQ--ACR----GTEL-DDGI----EA-----DS--------- C_intestinalis_ENSCINP00000003204 SCISMLEVINEVSTM-DHTGNDCCFVAFLSHGDD-------GC-VYGTDG-IVQIKKIVDQFRGDVCPSLAGKPKIFLFQ--ACR----GTLH-ETSVQL--SV-----DVV-DGEDQPC D_rerio_ENSDARP00000093958 SRDKVLKEIKEVAAA-DHVDADCFVCIFLSHGED-------GH-VYANDE-KIKIPEITDLFKGDKCRGLVGKPKIFIWQNKACR----GDKK-DDPV-A--PM-----SAE-DSD---- A_aegypti_AAEL014348-PA RLKDILLVIEKVSLM-DHSNSDCLLVAVLSHGDE-------GEVIYAHDC-PYQISSIWTQFTGDRCRTLVGKPKIFIIQ--ACR----GNDL-DSGV----KV-----EK--------- O_anatinus_ENSOANP00000005811 KAEEVMLKIHQASSS-NHADADCFLCVFLSHGQG-------NH-VYAYNG-KIDIPEMTSMFKGDQCRSLVGKPKIFIFQ--ACR----GEQH-DVGV-V--PL-----DVV-DSKISEQ M_domestica_ENSMODP00000007353 KAEDLLMTIHMVSTS-SHIDADCFLCVFLTHGEG-------NH-IYAYDA-KIDIQKLTAMFKGDKCQTLVGKPKIFVIQ--ACR----GDQH-DIPV-I--PL-----DVV-DHLSDKV C_intestinalis_ENSCINP00000011493 TKVEIINWIAAVSKA-DHSNYDCFACVILTHGGD-------KDVLYARDD-KMELKDFMQPFRGDNCPSLATKPKLFFIQ--ACR----GFKL-AEPVKV--RP--VQCDSL-NYDTTDG D_rerio_ENSDARP00000006831 TVAQIMQVLTTVAHD-DHSRCASLVCVLLSHGDE-------GV-FFGTDT-SVDLKSLTSLFRGDRCPSLVGKPKLFFIQ--ACR----GTEL-DPGV----ET-----DHP-DHPDI-- D_rerio_ENSDARP00000041413 SRDDVLLKIQEASAA-DHVDADCFVCIFLSHGED-------GH-VYANDK-KIEIPEITDLFKGDKCRSLVGKPKIFIWQKQACR----GDKL-DDAV-T--EM-----SVE-DVE---- M_musculus_ENSMUSP00000029626 RAEELLLKIHEVSTS-SHIDADCFICVFLSHGEG-------NH-VYAYDA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACR----GSQH-DVPV-V--PL-----DMV-DHQTDKL X_tropicalis_ENSXETP00000052017 RTLDILEKIQEASTA-DHSNADCFLCVFLSHGED-------RH-IYSYDS-LIDIQELTNSFKGDKCESLVGKPKIFIFQ--ACR----GEKH-DNPV-L--PT-----DET-DSV---T R_norvegicus_ENSRNOP00000013049 RAEELLLKIHEVSTS-SHVDADCFLCVFLSHGEG-------NH-IYAYDA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACR----GSQH-DVPV-V--PL-----DVV-DHQTDKL D_rerio_ENSDARP00000050929 KRHEVLSKITEAAAA-DHVDADCFVCVFLSHGEN-------GH-VYANDG-QIEIPEITDLFKGDKCRSLVGKPKIFIWQ--ACR----GDKH-DDPV-T--PM-----DVV-DSQ---- T_rubripes_ENSTRUP00000022652 TQAQVLEIITSAAKD-DHSNVDCFLVVFLSHGEN-------DH-IYTFDD-KINVQDITSLFKGDKCKSLVGKPKIFILQ--ACR----GDKH-DEPA-TAAAF-----DDV-DSE---L H_sapiens_ENSP00000265164 KAEELLLKIHEVSTV-SHADADCFVCVFLSHGEG-------NH-IYAYDA-KIEIQTLTGLFKGDKCHSLVGKPKIFIIQ--ACR----GNQH-DVPV-I--PL-----DVV-DNQTEKL T_rubripes_ENSTRUP00000040691 TVNQMKQLLVSAAEE-DHSACASFVCVLLSHGDE-------GV-FFGTDG-SVELKYLTSLFRGDRCKSLVGKPKLFFIQ--ACR----GNDL-DGGI----ET-----DSA-------- P_pygmaeus_ENSPPYP00000016744 KAEELLLKIHEVSTV-SHADADCFVCVFLSHGEG-------NH-IYAYDA-KIEIQTLTGLFKGDKCHSLVGKPKIFIIQ--ACR----GNQH-DVPV-I--PL-----DVV-DNQTDKL A_gambiae_AGAP004922-PA --------------------------MLMTHGDD-------DV-LYAYDG-PYSVDKLWESFMGNACTTLLGKPKLFFVQ--ACR----GSTF-DKGV----KL------GC-RDL---- E_caballus_ENSECAP00000013268 KAEELLLKIYEVSTS-SHADADCFVCVFLSHGEG-------NH-IYAYDA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACR----GDQH-DVPV-T--PL-----DVV-DHGTDKL G_aculeatus_ENSGACP00000022402 SVAQIQHVLTSVSKQ-DHSCSASFVCVLLSHGDG-------DL-FFGTDG-PVPLKSLTSLYRGDRCKSLVGKPKLFFIQ--ACR----GTEL-DPGI----EA-----DSV-------- D_rerio_ENSDARP00000072390 SANQMIDALRTVSEE-DHTDNSCFVCVLMSHGEE-------GT-ILGSDERWIPVKTLTSLLTSDLCPSLRDKPKIFFLQ--ACR----GVEY-DPGV----EA-----DSV-EAS---- G_aculeatus_ENSGACP00000024812 TADQMVDLLADVSKQ-DHRKSASFVCALLSHGDE-------DG-IYGTDG--TSLDDLTKFFKGDRCRSLVGKPKLFFIQ--ACR----GTDT-DRGV----NF-----DAD-ST----- B_taurus_ENSBTAP00000016642 RAEELLLKIHEASTA-SHVDADCFLCVFLSHGEG-------NH-IYAYDA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACR----GSQH-DVPV-I--PL-----DVV-DHRTDTP T_nigroviridis_ENSTNIP00000021186 KQQEVLDIINAAAKA-DHSDVDCFLLVFLSHGEN-------DH-IYANDD-KISIQDITSLFKGDKCKSLVGKPKIFIWQ--ACR----GDKH-DEPA-TAAAF-----DDV-DSE---S P_troglodytes_ENSPTRP00000028104 KAEELLLKIHEASTV-SHADADCFVCVFLSHGEG-------NH-IYAYDA-KIEIQTLTGLFKGDKCHSLVGKPKIFIIQ--ACR----GNQH-DVPV-I--PL-----DVV-DNQTEKL A_aegypti_AAEL012143-PA -------------MM-DHSEHDCVSITILSHGEL-------GY-LYAKDC-QYKLDIIWSYFTANRCPTLAGKPKVFFIQ--ACQ----GDQL-DAGV----TL-------A-ERTET-- O_latipes_ENSORLP00000010793 TVDQMKKLFRQMSNQ-DHSKFASFACVILSHGEE-------GV-IYGTDG-PVSFNKLIECLKGRSCLSLVGKPKLFFIQ--ACR----GTLF-DEGI----EH-----DAK-------- G_aculeatus_ENSGACP00000024816 TVDQMIQLLVKVSKQ-DHSNSASFVCVLLSHGDE-------GV-IYGTDG-FEKLDDLTKFFKGDRCRSLVGKPKLFFIQ--ACR----GTEL-DEGS----QI-----EAD-SV----- O_anatinus_ENSOANP00000005531 SRQEMVATLEECSRRPDHDVRDCLVCCVLSHGES-------GA-VYSADEELIPIRQIMSYFTAKDCPSLAHKPKLFFIQ--ACQ----GKDI-QEAVQI--EP-----DAR-NPDLDPQ C_familiaris_ENSCAFP00000016791 KAEELLLKIHEASTS-SHIDADCFLCVFLSHGEG-------NH-IYAYDA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQ--ACR----GDQH-DVPV-L--PL-----DVV-DHRTDKL G_gallus_ENSGALP00000013591 TAEEIRNIVNNYRCM-DHNNKDCFVCCILSHGKK-------GI-IYGVDGQEVPIQELTTSFTGQNCQSLAGKPKVFFVQ--ACQ----GDAY-QKGVTI--ET-----DSG-EQDYS-- T_nigroviridis_ENSTNIP00000001216 TGKEILSLMQELADK-SQQRWDCLVCCILSHGLE-------GC-VHGVDGDQVSIKKLIEPFLGTNCPAMAGKPKLFFIQ--ACQ----GKKQ-QGVVHL--ES-----DGA-EHSDV-- C_familiaris_ENSCAFP00000017933 TKGHLDEVLQEFKCHPDHVDGDCFVFCVLTHGKF-------GA-VYSSDGTLVPIREIMSHFTAQKCPGLAHKPKLFFIQ--ACQ----GKGI-QTPVSI--EA-----DAV-NPEHV-- M_mulatta_ENSMMUP00000037892 TVEKIYKILKTYQLM-DHSNKDCFICCILSHGDK-------GI-IYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQ----GDNY-QKGIPV--ET-----DSE-E-QPY-- G_gallus_ENSGALP00000013506 TSDQIKELMQAWQRSEDHKNRDCFVCCILSHGES-------GA-VYGKDGKLVSIRTIMTYFTAKQCPQLTEKPKLFFVQ--ACQ----GKEV-QRPVYV--ET-----DAR-VPDFSSV C_intestinalis_ENSCINP00000025743 TRSKILKWLKDVAAA-SHESYDCFGCAILTHGDK-------NNELYARDA-SMNITDFTNPFTADKCPTLAGKPKLFFVQ--ACR----GHKR-DTAVPF--TL-----NVA-STI---- G_aculeatus_ENSGACP00000005791 EGEQMLTALRELASR-NHGQADCLVCCVLSHGDE-------GC-VYGVDGHTVAIKELKEPFNGLNCASLAGKPKLFFIQ--ACQ----GTGE-QKAVNV--VP-----DGP-EDSAV-- A_carolinensis_ENSACAP00000001629 TSIEMENHLKQWQSFENWKDMDCLVCCILSHGES-------GK-IYGTDGNLIPIRTIMSYFTAKQCPQLAKKPKLFFIQ--ACQ----GEKT-QQPVYL--ET-----DDE-YGSFP-- D_rerio_ENSDARP00000075318 TVSAMKRTLKEYSE--DRKHGDCFVCCVLSHGNE-------SG-VLGSDEKICPVDDITSPFNGANCSSLAGKPKVFFIQ--ACR----GHEI-QSKVMV--AD-----GSG-GSRTQ-- M_domestica_ENSMODP00000036247 TAEGIQQVLKTFKDN-NHESKDCFVCCLLSHGNK-------GT-IYGIDGKEVPIRDLTSYFSGSNCPSLAGKPKVFFIQ--ACQ----GKAT-QYGISL--DT-----DSE-QQRES-- P_troglodytes_ENSPTRP00000021879 TVQQIYEILKIYQLM-DHSNMDCFICCILSHGDK-------GI-IYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQ----GDNY-QKGIPV--ET-----DSE-E-QPY-- C_intestinalis_ENSCINP00000011503 TTDEIRDHLQELSYQ-DHSNCDCFVCVVLSHGES-------DGVLYTKDG-DIHLKEILDSFKASRCPSLAGKPKLFFIQ--ACR----GEKR-STPVEI--EYKFDVTDST-PPE---- H_sapiens_ENSP00000351273 TVEQIYEILKIYQLM-DHSNMDCFICCILSHGDK-------GI-IYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQ----GDNY-QKGIPV--ET-----DSE-E-QPY-- D_rerio_ENSDARP00000075645 QASDMRNVIKEFAEK-DHSQMNAFVCCILTHGEK-------GT-VLGTDGKQVPIRELSQPFA--ECRSLASKPKLFFIQ--ACQ----GNMR-QQGLWM--AH-----ERE-NTTEEEA M_musculus_ENSMUSP00000027189 TANEIHEILEGYQSA-DHKNKDCFICCILSHGDK-------GV-VYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQ--ACQ----GSNF-QKGVPD--EA-----GFE-QQNHT-- R_norvegicus_ENSRNOP00000016613 TASQIHEVLVSYQSK-DHKGKDCFICCILSHGDK-------GI-VYGTDGKEASIYELTSYFTGSKCPSLAGKPKIFFIQ--ACQ----GNNF-QKAVPVPDET-----GLE-Q-EHV-- P_pygmaeus_ENSPPYP00000014606 TVEQIYEILKIYQLM-DHSNMDCFICCILSHGDK-------GI-IYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQ----GDNY-QKGIPV--ET-----DSE-G-QPY-- D_rerio_ENSDARP00000063081 TAAEMKNILQALGRT---VDGDCFVCCVLSHGVE-------EG-VCGTDGSLVSVDEIRNPFTGVNCQKLVGKPKLFFIQ--ACR----GQRK-QLRVNA--QA-----DGP-GDGESEM G_aculeatus_ENSGACP00000024809 TADQIVDLLRDVSTQ-DHSNSGSFVCVLLSRGDE-------GG-IYGTDGSFVNLDELTKFVDGNGCRSLVGKPKLLFIQ--AAR----GNKL-DDGT----LS-----EGD-SM----- H_sapiens_ENSP00000286186 TKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRF-------GA-VYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQ--ACQ----GEEI-QPSVSI--EA-----DAL-NPEQA-- D_rerio_ENSDARP00000075650 DTAEIRNILKDLGRT---VDGDCFVCCILSHGRR-------EG-VCGTDGNYLSIDEIRDPFTGVKCQKLVGKPKLFFIQ--GCR----GANSLQACVKV--EA-----DAG-NSKAK-- O_anatinus_ENSOANP00000006351 TAEQILETLQSYQRM-DHSAQDCFVCCILSHGDR-------GV-VYGTDGQQASIRSLTSYFTGSRCPTLAGKPKLFFIQ--ACQ----GDAY-HLAVAL--ET-----DNG-TDKGTAA T_guttata_ENSTGUP00000010625 TAEEIRETVNIFQSA-DHEDKDCFVCCILSHGKK-------GI-IYGVDGQEVPIRELTTSFTAQNCSSLAGKPKVFFIQ--ACQ----GDAF-HKGVAI--ET-----DSV-EEDSS-- E_caballus_ENSECAP00000004055 TAKDICDALREYQEM-DHKKKDCFICCILSHGDK-------GI-IYGCDGQEASIYELTSYFTGSNCPSLAGKPKIFFIQ--ACQ----GDNY-QKGIAV--ET-----DSE-LTDAY-- O_cuniculus_ENSOCUP00000006164 TAKQICDILQSYQSM-DHKDRDCFVCCILSHGDK-------GI-IYGTDGQEACIYDLISYFTGSKCSSLAGKLKVFFIQ--ACQ----GDKY-QQAVPA---I-----DSE-QQSYL-- T_rubripes_ENSTRUP00000044662 TSKKMSSLIQELAKT-SQRDWDCVMCCVLSHGLE-------GG-VYGVDGGTVEIRKLMEPFSGTNCPSLAGKPKIFFIQ--ACQ----GSRQ-QDIVYT--DA-----GTP-GHGYV-- C_familiaris_ENSCAFP00000017899 TAKKICEVLQSYQSM-DHSSKDCFICCILSHGDK-------GI-IYGSDGQEAPIYELTSYFTGSKCPSLAGKPKIFFIQ--ACQ----GDKY-QKGIAV--ET-----DSE-QKEAY-- P_pygmaeus_ENSPPYP00000014602 TKGEMEEVLQEQKCNPAHADGDCFVFCILTHGKF-------GA-VYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQ--ACQ----GEEI-QPSVSI--EA-----DAL-NPEQP-- M_mulatta_ENSMMUP00000037898 TKGEMEEVLQKEKCNPAHADGDCFVFCILTHGED-------GA-VYSSDEALIPIREIMSHFTALQCPGLAEKPKLFFIQ--ACQ----GEKI-QLSKSI--EA-----DAL-NPEQA-- D_rerio_ENSDARP00000024255 TGDQILQALMDLSTQ-DHTQADCVVCCILSHGRL-------ND-IIGVDGKAVPFKELMETLSPFRCSSLYQKPKLFFIQ--ACR----GTQN-QRAVFP--QT-----FTE-DEDVL-- M_musculus_ENSMUSP00000030747 TAKKMVTALMEMAHR-NHRALDCFVVVILSHGCQASHLQFPGA-VYGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQ--ACG----GEQK-DHGFEV--AC-----TSS-QGRTLDS E_caballus_ENSECAP00000021726 TKEGLEKVLQEYRNHPGHASGDCFVFCVLTHGKF-------GA-VYSSDGILIPIREIMSHFTAQRCPALAHKPKLFFIQ--ACQ----GEEV-QPSVSI--EA-----DAV-NPENV-- G_gorilla_ENSGGOP00000000205 TVEQIYEILKIYQLM-DHSNMDCFICCILSHGDK-------GI-IYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ--ACQ----GDNY-QKGIPV--ET-----DSE-E-QPY-- X_tropicalis_ENSXETP00000008971 MSEQIRDCLKRFKSR-DHSERDCFVCCILTHGES-------GT-VMGSDDKEVSIREIMSYFTAISCTSLVLKPKLFFIQ--ACQ----GKFT-HPSSKV--EA-----DAI-VPEEN-- T_rubripes_ENSTRUP00000045375 KQRQIKHELSALSKM-DHSQYDCCVVVLLSHGTEVSHSRFPGA-VYGVDGQFVPVQHITTYLNGQHCPSLQGKPKLFFIQ--ACG----GDEK-DTGFEV--SP-----DEF-EPPVVSA P_troglodytes_ENSPTRP00000048878 TKVEMEEVLQRQKCNPAHADGDCFVFCILTHGRF-------GA-VYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQ--ACQ----GEEI-QPSVSI--EA-----DAL-NPEKA-- M_domestica_ENSMODP00000005512 TCN---ELLDSVSKE-DHSQSSSFIGAVLSHGEE-------GV-IFGPDE-SVELKRLMCFFRGDKCRRLRGKPKLLIIQ--ACR----GTEL-DCG-----ET-----DSG-TD----- O_cuniculus_ENSOCUP00000011835 KAEELLLKIHEVSTS-SHLDADCFLCVFLSHGEG-------NH-IYAYDA-KIEIQTLTGLFKGDKCQSRVGKPKIFIIQ--XXX----XXXX-XXXX-X--XX-----XXX-XXXXXXX T_guttata_ENSTGUP00000014729 -----------------------FACILLNHGEE-------GL-IYGTDG-PMAIKSLTALFRGDKCKSLIGKPKLFFIQ--ACR----GSEF-DEGI----QT-----DSG-PAN-DTL M_domestica_ENSMODP00000004412 SAKGMGAALQQLAER-DHSALDCCVVVILSHGCQASHIQFPGA-IHGTDGASISVERIVNIFSGSRCPSLGGKPKLFFIQ--ACG----GDQR-DHGFQV--SS-----NIP-EDKSPGS B_taurus_ENSBTAP00000038128 TAKGICEVLESYQKK-DHKNKDCFICCILTHGNK-------GI-IYGSDGQEASIYELTSYFTGLKCPSLIGKPKIFFIQ--ACQ----GDKY-QKGVAV--ET-----DSE-QMEAY-- G_gallus_ENSGALP00000013571 EAKQIFAKVNEYSKK-DHSNMDCFVCFILSHGEK-------GK-IKGVDNELVNIKDLLSCFSGSNCPSLAGKPKLFFIQ--ACQ----GSVG-HPAVTV--KE-----DCS-GHLET-- B_taurus_ENSBTAP00000003205 TAKQMVQALMQLARQ-DHSALDCCVVVILSHGCQASHLQFPGA-VYGTDGCPVSVERIVNTFNGTGCPSLRGKPKLFFIQ--ACG----GEQK-DHGFEV--ES-----TSP-EDKTPSS T_nigroviridis_ENSTNIP00000013855 KQRQIRQELSALSKV-DHSQYDCCVVVILSHGTEVSHSRFPGA-VYGVDGQFVPVQHIATYLNGQYCPSLQGKPKLFFIQ--ACG----GDEK-DTGFQV--SP-----DEF-EPPVVGA O_cuniculus_ENSOCUP00000003895 TKEDLEALLQEEKHHPDHDDGDCFVFCVLTHGIF-------GA-VYSSDGVLIPIREIVSHFTAKQCPGLAGKPKLFFIQ--ACQ----GKEI-QSSAPI--EA-----DAV-NPECV-- M_domestica_ENSMODP00000036251 EKREMEDILQQCSTSPEHRESDCFVCCVLTHGES-------GS-VFSSDEEKIAIRELTSYFKAHRCPGLANKPKLFFFQ--ACQ----GPDI-QESMLL--EE-----DAKISPPIQ-- O_latipes_ENSORLP00000005993 TCDKMEHLLKEASQE-DHSDSSCFACILLSHGEE-------GM-IYGTDG-AIPIKTMTSLFRGDKCKSLVGKPKLFFIQ--ACR----GSEF-DEGV----QT-----DSG-PPN-DTI G_aculeatus_ENSGACP00000007379 KQRQIKHALSALSKK-DHSQCDCCVVIMLSHGTEVSHNRFPGA-VYGVDGQHVPVQLITNYLNGQHCPSLQGKPKLFFIQ--ACG----GGER-DTGFEV--SP-----DEV-EPSIGGA R_norvegicus_ENSRNOP00000017972 TAKKMVTALMEMAHR-DHRALDCFVVVILSHGCQASHLQFPGA-VYGTDGCSVSIERIVNIFNGTGCPSLGGKPKLFFIQ--ACG----GEQK-DHGFEV--AF-----TSS-QDKAFDS T_guttata_ENSTGUP00000017449 KAQEMVLELLKLSRQ-DHSALDCCIVVILSHGCQTSHIQFPGG-VYGTDGKPIPIEKIVNYFNGSSCPSLRGKPKLFFIQ--ACG----GEQR-DQGFVV--DC-----DSP-KEEALGD O_anatinus_ENSOANP00000015596 TAEEMVKALNKLAKK-DHSALDCCVVVILSHGYQASHIQFPGG-IHGTDGESISVETIVNYFNGSRCPSLGGKPKLFFIQ--ACG----GEKK-DPGFEV--NL-----DSP-EDHPTGS G_gallus_ENSGALP00000002083 KAQEIDVELRKLARL-DHSALDCCLVVILSHGCQTSHIQFPGG-IYGTDGKIIPIERIVNYFNGSQCPSLRGKPKLFFIQ--ACG----GEQK-DQGFEV--DC-----ESP-QDETCRR T_guttata_ENSTGUP00000010628 TSGEIINLMKTWQHKQDHEDRNCFICCILSHGKS-------GA-ICGTDDRPVSIRTLMSHFTAKQCPQLAAKPKLFFIQ--ACQ----GNKI-QDPVYV--NT-----DGP-TPDLSSM C_intestinalis_ENSCINP00000024485 DQREMEKVIQEYTKK-DHSDKDCFVCVVMSHGLS-------GC-VYGVDGLSLSTSKISKSFRPGMCSSLTGKPKIFFFQ--ACQ----GDRT-MDGHSA--PV-----DDV-ESDGA-- C_elegans_C48D1.2 TGRGMLLTIRDFAKH--ESHGDSAILVILSHGEE-------NV-IIGVDDIPISTHEIYDLLNAANAPRLANKPKIVFVQ--ACR----GERR-DNGFPVLDSV-----DGV-PAFLRRG C_intestinalis_ENSCINP00000028692 ERKQIRRKLYELSEM-DHGDHDCFACAILTHGGK-------DNILYSHDD-EMKLKDFTTPFEADKCRSLASKPKLFFVQ--ACR----GDLL-DRGAKV--IH-----LKQ-STG---- T_rubripes_ENSTRUP00000024467 TAEAILRELKRLGKR-DFMNEDALVVCVLSHGLK-------GC-IFGTDGEEVSLQDFTQPFVSSQAPTLAGKPKLFFIQ--ACQ----GEKL-QKGYAA--WP-----PRP-EQEMAKA M_mulatta_ENSMMUP00000040583 TAKEMVLALLELARR-DHSALDCCVVVILSHGCQASHLQFPGA-VYGTDGCPVSVERIVNIFNGTSCPSLGGKPKLFFIQ--ACG----GEQK-DHGFEV--AS-----TSP-EDESSGS R_norvegicus_ENSRNOP00000040783 THEEIMELMDNVSKE-DHSERSSFVCVIPRHGDK-------GL-IFGTNR-PVDLEKLTSFFRDDYCQSLTGKKKLFITQ--DCQ----GTEL-DCGI----ET-----DSG-TE----- C_familiaris_ENSCAFP00000023986 TAKQMVQALVELARR-DHSALDCCVVVVLSHGCEASHRQFPGA-VYGTDGCPVSIEKIVNIFNGTGCPSLGGKPKLFFIQ--ACG----GEQK-DHGFAV--AS-----ASP-EDRSPGS E_caballus_ENSECAP00000015102 TAKQMLRALGELARR-DHGALDCCVVVILSHGCQASHLQFPGA-VYGTDGCPVSIESIVNIFNGTGCPSLGGKPKLFFIQ--ACG----GEQK-DPGCKV--DS-----TSP-EDRTPGS D_rerio_ENSDARP00000047019 KSKRIRHEMASLAKK-DHSTYDCCVVIILSHGTEASHNRFPGA-VHGVDGPAVPIQIITNYLNGQNCPSLQGKPKLFFIQ--ACG----GGEK-DIGFEV--SP-----DDV-QPSIGGI P_troglodytes_ENSPTRP00000056642 TAKEMVLALLELARQ-DHGALDCCVVVILSHGCQASHLQFPGA-VYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQ--ACG----GEQK-DHGFEV--AS-----TSP-EDESPGS 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0082755 VPEPAA--------------A-V--------------------QPI-TYAIPSTADILVFYSTFD--KFFSFRNVDDGSWFIQSLCRVLDQAAANEAATPEGVELL-----------RLL A_aegypti_AAEL003444-PA -DMVDS--------------R-Q--------------------EQV-LYSIPAMADLLVMYSTYD--GYYSWRNPRQGSWFIQSLCTELDENG-------RVRDLL-----------TLL A_gambiae_AGAP011951-PA -DSVDTQS------------S-P--------------------GSM-RYVIPAMADLLVMYSTYD--GHYSWRNPSKGSWFIQSLCAELGASA-------HCKELL-----------HIL A_gambiae_AGAP011952-PA -DTVDALS------------S-S--------------------SQR-TCVIPTMADVLVMYSAFD--GHYSWRNPTHGSWFIQSLSIELNQHA-------HRKELL-----------QLL A_gambiae_AGAP004920-PA -QVA----------------K-TVVPYAMRELPQPSIVPGCPKSSI-QYAIPSMADLLVMYSTYK--GHYSWRNPSTGSWFIRALCDELREHG-------NSKELL-----------QLL A_gambiae_AGAP004921-PA -DSD----------------H-F--------------------SSH-KYVIPTTADLLVMYSSYK--GHVSWRSPRGGSWFIQALCVELETNW-------KHMELL-----------QLL A_gambiae_AGAP000830-PA --------------------DSS--------------------SSMLTFKIPMYADFMIAYSTIP--GFYSWRNTQKGSWFIQSLCHELNQNG-------RKYDLM-----------VLL A_aegypti_AAEL003439-PA -DVVDSP-------------N-D--------------------SSA-LYFIPTMADFLVMYSTYD--GYYSGKDPLQRSCLIQSLCMELDENG-------RERDLL-----------ALL A_gambiae_AGAP011949-PA ----------------------V--------------------DPA-PGIIPMYADLLVMYSSYD--RHISVRCKDKGSWFIQSLCQVLRANI-------AGKELI-----------SLL M_domestica_ENSMODP00000005556 ----------------------E--------------------DIA-CQKIPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQALCAVLKQHA-------HKLEIM-----------QIL X_tropicalis_ENSXETP00000003217 ----------------------P--------------------GEE-IQRIPVEADFLYAYSTVP--GYYSWRNTMNGSWFIQSLCEMIKLYG-------PHLELI-----------QIL A_carolinensis_ENSACAP00000009923 EM--------------------D--------------------ANP-RYKIPVEADFLYAYSTVP--GYFSWRNPGKGSWFVQSLCSVLNDHG-------KELEVL-----------QIL A_carolinensis_ENSACAP00000002670 ----------------------D--------------------ESM-CQKIPVEADYLYAYSTAP--GYYSWRNSSDGSWFIQSLCSMLKQYS-------HKLELM-----------QIL P_troglodytes_ENSPTRP00000005216 -T--------------------D--------------------ANP-RYKIPVEADFLFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIM-----------QIL H_sapiens_ENSP00000358327 -T--------------------D--------------------ANP-RYKIPVEADFLFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIM-----------QIL D_melanogaster_FBpp0071971 --------------------DGE--------------------SST-SYKIPIHADFLFSYSTIP--GYFSWRNINNGSWYMQSLIRELNANG-------KKYDLL-----------TLL O_cuniculus_ENSOCUP00000009498 -T--------------------D--------------------ANP-RHKIPVEADFLFAYSTVP--GYYSWKNPGRGSWFVQALCSILDEHG-------KELEVM-----------QIL G_gallus_ENSGALP00000014503 ET--------------------D--------------------ANP-RYKIPVEADFLFAYSTVP--GYYSWRNPGRGSWFVQSLCSVLNEHG-------KQLEIM-----------QIL O_anatinus_ENSOANP00000000517 ----------------------D--------------------DGS-EQKIPVEADFLYAYSTAP--GYYSWRNSMNGSWFIQALCAMLKQHA-------HTLELL-----------HIL M_mulatta_ENSMMUP00000001627 -T--------------------D--------------------ANP-RYKIPVEADFLFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIM-----------QIL P_pygmaeus_ENSPPYP00000003106 -T--------------------D--------------------ANP-RYKIPVEADFLFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIM-----------QIL R_norvegicus_ENSRNOP00000022693 -T--------------------D--------------------ANP-RYKIPVEADFLFAYSTVP--GYYSWRNPGKGSWFVQALCSILNEHG-------KDLEIM-----------QIL G_gallus_ENSGALP00000017288 ----------------------D--------------------ETV-CQKIPVEADFLYAYSTAP--GYYSWRNAAEGSWFIQSLCRMLKEHA-------RKLELM-----------QIL B_taurus_ENSBTAP00000008706 -T--------------------D--------------------ANP-RYKIPVEADFLFAYSTVP--GYYSWRNPGSGSWFVQALCSILNEHG-------KSLEIL-----------QIL A_gambiae_AGAP011950-PA ----------------------E--------------------KPI-CVEIPMYADLLVMYSSYD--QYVSYRDKEEGSWFIQSLCQVLGANI-------AGKDLL-----------TLL E_caballus_ENSECAP00000013731 -T--------------------D--------------------ANP-RYKVPVEADFLFAYSTVP--GYYSWRNPGSGSWFVQALCSILNEHG-------KSLEII-----------QIL P_pygmaeus_ENSPPYP00000017020 ----------------------D--------------------DMA-CHKIPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFM-----------HIL T_nigroviridis_ENSTNIP00000022078 ET--------------------D--------------------ANP-RHKIPVEADFLFAYSTVP--GYYSWRNPGRGSWFVQALCNVLNEFG-------KQLEIM-----------QIL D_melanogaster_FBpp0084848 --------------------DGD--------------------SSM-SYKIPVHADFLIAYSTVP--GFYSWRNTTRGSWFMQSLCAELAANG-------KRLDIL-----------TLL P_troglodytes_ENSPTRP00000054330 ----------------------D--------------------DMA-CHKIPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFM-----------HIL H_sapiens_ENSP00000311032 ----------------------D--------------------DMA-CHKIPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFM-----------HIL X_tropicalis_ENSXETP00000035938 ET--------------------D--------------------ANP-RHKIPVEADFLYAYSTVP--GYYSWRNPGRGSWFVQALCNVLNEHG-------KELEVM-----------QIL G_gorilla_ENSGGOP00000007184 -T--------------------D--------------------ANP-RYKIPVEADFLFAYSTVP--GYYSWRSPGRGSWFVQALCSILEEHG-------KDLEIM-----------QIL T_guttata_ENSTGUP00000006879 ----------------------E--------------------ETM-CQKIPVEADFLYAYSTAP--GYYSWRNSAEGSWFIQSLCKMLKEHA-------RKLELM-----------QIL G_aculeatus_ENSGACP00000008661 ET--------------------D--------------------ANP-RHKIPVEADFLFAYSTVP--GYYSWRNPGRGSWFVQALCNVLNEFG-------KQLEIM-----------QIL C_familiaris_ENSCAFP00000016420 -T--------------------D--------------------ANP-RYKIPVEADFLFAYSTVP--GYYSWRSPGSGSWFVQALCSTLNEHG-------KSLEIL-----------HIL M_musculus_ENSMUSP00000026062 -I--------------------D--------------------ANP-RNKIPVEADFLFAYSTVP--GYYSWRNPGKGSWFVQALCSILNEHG-------KDLEIM-----------QIL M_musculus_ENSMUSP00000091238 ----------------------E--------------------EMA-CQKIPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQSLCSMLKLYA-------HKLEFM-----------HIL A_gambiae_AGAP012945-PA -QVA----------------K-T--------------------SSI-QYAIPSMADLLVMYSTYK--GHYSWRNPSTGSWFIRALCDELREHG-------NSKELL-----------QLL M_mulatta_ENSMMUP00000015808 ----------------------D--------------------DMA-CHKIPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKQYA-------DKLEFM-----------HIL T_rubripes_ENSTRUP00000031759 ET--------------------D--------------------ANP-RHKIPVEADFLFAYSTVP--GYYSWRNPGRGSWFVQALCNVLSEFG-------KQLEIM-----------QIL B_taurus_ENSBTAP00000021099 ----------------------D--------------------DMA-CQKIPVEADFLYAYSTAP--GYFSWRNAKNGSWFIQALCEMLKKHA-------HRLELM-----------HIL E_caballus_ENSECAP00000019797 ----------------------D--------------------DMA-CQKIPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKLYA-------HKLELM-----------HIL D_rerio_ENSDARP00000019984 ET--------------------D--------------------ANP-RHKIPVEADFLFAYSTVP--GYYSWRNPGRGSWFVQALCNVLSEFG-------KQLEIM-----------QIL C_familiaris_ENSCAFP00000032189 ----------------------D--------------------DMA-CQKIPVEADFLYAYSTAP--GYYSWRNSKDGSWFIQSLCAMLKLYA-------HKLEFM-----------HIL A_gambiae_AGAP009832-PA ----------------------D--------------------GVA-RYSIPTHADFLFAYATIP--GFMAFRNTTEGSWFINELCKELQENG-------HRYDIN-----------TLL T_guttata_ENSTGUP00000011206 ET--------------------D--------------------ANP-RYKIPVEADFLFAYSTVP--GYYSWRNPGRGSWFVQSLCSVLNEHG-------KQLEIM-----------QIL M_domestica_ENSMODP00000005560 ----------------------E--------------------DVA-CHKIPVEADFLYAYSTVP--GYYSLRDPKDGSWFIQALCAVLKQHA-------HKLEIM-----------QIL O_anatinus_ENSOANP00000002508 -S--------------------D--------------------ANP-GCRIPVEADFLFAYSTVPVKGYYSWRNVDRGSWFVQALCSVLHEHG-------KELEIM-----------QLL R_norvegicus_ENSRNOP00000014096 ----------------------D--------------------DMA-CQKIPVEADFLYAYSTAP--GYYSWRNSRDGSWFIQSLCAMLKLYA-------HKLEFM-----------HIL T_guttata_ENSTGUP00000004278 PGNETD--------------V-D--------------------AAG-VYTLPAGADFIMCYSVAQ--GYYSHRDTINGSWYIQDLCETLRKHG-------SSLEFA-----------ELL G_aculeatus_ENSGACP00000023055 KTNEVV--------------V-D--------------------ASV-LHTLPAGADFIMCYSVAE--GYYSHRETINGSWYIQDLCELLQRYG-------DSHEFT-----------EVL D_rerio_ENSDARP00000071815 ----------------------G--------------------DEE-TQRIPVEADFLYAYSTAP--GYYAWRNVANGSWFISSLCDMLLKYG-------KQLEIM-----------QVM A_carolinensis_ENSACAP00000012644 DINETE--------------V-D--------------------TAA-VYTLPAGADFLMCYSVAE--GYYSHRETINGSWYIQDLCEMLKRHG-------SSLEFT-----------DLL G_gallus_ENSGALP00000019870 TVNQTE--------------V-D--------------------AAG-VYTLPAGADFIMCYSVAQ--GYFSHRETVNGSWYIQDLCEALGKHG-------SSLEFT-----------ELL A_gambiae_AGAP012544-PA ----------------------E--------------------EPV-DVKIPMYADLLVMYSSFE--HHSSIRCRNEGSWFIQSFCQVLGANI-------AKTELQ-----------ALL T_nigroviridis_ENSTNIP00000009934 ----------------------E--------------------DNS-TTKIPVEADFLYAFSTAP--GYYSWRNTMSGSWFMQSLCDTISKYG-------KELELQ-----------HIL O_latipes_ENSORLP00000010095 -------------------------------------------KED-TTKIPVEADFLYAFSTAP--GYYSWRNTMTGSWFINSLCEMLSKYG-------KELELL-----------HIM C_intestinalis_ENSCINP00000003204 VEV-------------------D--------------------AAP-VPTLPSGSDYLFCYSVAE--GYYSHRDTLYGSWFIQDFTDVMEQLVLNKGKQQDKVDFI-----------DVL D_rerio_ENSDARP00000093958 --DEMA--------------V-D--------------------AGV-SNTLPAGADFIMCYSTTE--GFCSFRDPLNGTWYIQDLCEIMGRYR-------SQLEFT-----------NIL A_aegypti_AAEL014348-PA ----------------------D--------------------GVA-RYSIPTNADFLFAFATIP--GYMSFRNTKNGSWFIRELCNELNENG-------QRYDML-----------TLL O_anatinus_ENSOANP00000005811 DVNETE--------------V-D--------------------AAS-VYTLPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGRYG-------SSLEFT-----------ELL M_domestica_ENSMODP00000007353 DVNETE--------------V-D--------------------AAS-VYTLPAGADFLMCYSVAE--GYYSHRETVHGSWYIQDLCEMLEKYG-------SSLEFT-----------ELL C_intestinalis_ENSCINP00000011493 GSA-------------------T--------------------VDE-FATIPAEADFLIAQSTVP--KYYSWRNKSNGSIFIQALCLTFNLFG-------EKQEIM-----------QMM D_rerio_ENSDARP00000006831 -------------------------------------------PDG-RVRIPVEADFLYAYSTVP--GYYSWRNTMTGSWFIQSLCEMMTKYG-------SELELL-----------QIM D_rerio_ENSDARP00000041413 ----MA--------------V-D--------------------AGV-LYTLPAGADFIMCYSTAE--GFCSFREPLNGSWYIQDLCEILGRYH-------SELQFT-----------DIL M_musculus_ENSMUSP00000029626 -DNVTQ--------------V-D--------------------AAS-VYTLPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLARYG-------SSLEFT-----------ELL X_tropicalis_ENSXETP00000052017 LTNITE--------------V-D--------------------AAS-LYTLPAGADFIMCYSVAE--GYYSHRETVNGSWYIQDLCEVLKAHA-------ASLEFT-----------EIL R_norvegicus_ENSRNOP00000013049 DDNVTQ--------------V-D--------------------AAS-VYTLPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLARHG-------SSLEFT-----------ELL D_rerio_ENSDARP00000050929 VTNDMV--------------V-D--------------------AGV-LYTLPAGADFIMCYSVAE--GYYSHRETVNGSWYIQDLCEILRRYG-------SELEFA-----------EIL T_rubripes_ENSTRUP00000022652 KKNEVE--------------V-D--------------------ASA-VYTLPAGADFIMCYSVAE--GYYSHRETVNGSWYIQDLCDLLRKYG-------DSLEFT-----------ELL H_sapiens_ENSP00000265164 DTNITE--------------V-D--------------------AAS-VYTLPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFT-----------ELL T_rubripes_ENSTRUP00000040691 ----------------------A--------------------DSS-TTKIPVEADFLYAFSTAP--GYYSWRNTTSGSWFMQSLCDAISKYG-------KELELQ-----------HIL P_pygmaeus_ENSPPYP00000016744 DTNITE--------------V-D--------------------AAS-VYTLPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFT-----------ELL A_gambiae_AGAP004922-PA -DSD----------------H-F--------------------SSH-KYVIPTTADLLVMYSSYK--GHVSWRSPRGGSWFIQALCVELETNW-------KHMELL-----------QLL E_caballus_ENSECAP00000013268 DANVTQ--------------V-D--------------------AAS-VYTLPAGADFLMCYSVAE--GYYSHRETINGSWYIQDLCEMLARFG-------SSLEFT-----------ELL G_aculeatus_ENSGACP00000022402 -------------------------------------------KDE-TTRIPVEADFLYAFSTAP--GYYSWRNTTTGSWFMQSLCDMISKYG-------KELELQ-----------HIM D_rerio_ENSDARP00000072390 --------------------E-D--------------------FFG-ISDVP-ELDFLCCYSTVE--GYFAWRNPETGSIFIRELCKTLMD---------CRLEII-----------QIL G_aculeatus_ENSGACP00000024812 ----------------------D--------------------GQM-LQSIPLEADFLYAYSTPS--GYYSWRNTQNGSCFMQSLCEILHSFS--------QLELM-----------QIM B_taurus_ENSBTAP00000016642 DANLTQ--------------V-D--------------------AAS-VYTLPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKFG-------SSLEFT-----------ELL T_nigroviridis_ENSTNIP00000021186 KKNEVE--------------V-D--------------------ASA-VHTLPAGADFIMCYSVAE--GYYSHRETVNGSWYIQDLCDLLLRYG-------DSLEFT-----------ELL P_troglodytes_ENSPTRP00000028104 DTNITE--------------V-D--------------------AAS-VYTLPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFT-----------ELL A_aegypti_AAEL012143-PA --------------------DSA--------------------GSM-SYKIPAHADFLIAYSTIP--GFYSWRNTQKGSWFMQSLCQELTQHG-------KKYDLL-----------TLL O_latipes_ENSORLP00000010793 -------------------------------------------DDT-SEKIPLEADFLFAYSTVS--GYYSWRSTANGSWFIQSLCEMLEKFS-------KTLDLM-----------QIM G_aculeatus_ENSGACP00000024816 ----------------------G--------------------GQT-SDRIPVEADFLYAYSTAP--GYYAWRNTQNGSWFMQSLCEMLRRFS-------GQLELM-----------QIM O_anatinus_ENSOANP00000005531 PEPPPA--------------P-R--------------------ESP-KDSIPAEVDFLLGMATVD--GYASFRHVNQGTWYIQALCRQLALLVP------RREDIL-----------SIL C_familiaris_ENSCAFP00000016791 EDNVTE--------------V-D--------------------AAS-VYTLPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKFG-------SSLEFT-----------ELL G_gallus_ENSGALP00000013591 ---LET--------------D-A--------------------RFQ-LDCIPSEADFLLGMATLQ--DYVSYRSPSQGTWYIQSLCQHLESSCP------RGEDIL-----------TIL T_nigroviridis_ENSTNIP00000001216 ----DT--------------D-A--------------------VRL-SNCIPSHADFLLGMATVP--DYVSYRDRERGTWYIQSLCEYLVKMVP------RGFDLM-----------SIL C_familiaris_ENSCAFP00000017933 ----------------------S--------------------PSL-KDSIPDAADFLLGLATVP--GYVSFRHVEKGSWYIQSLCNRLKSLVP------RHEDIL-----------SIL M_mulatta_ENSMMUP00000037892 ---LEM--------------DLS--------------------SPQ-TRYIPDEADFLLGMATVN--NCVSYRNPAEGTWYIQSLCQSLRERCP------RGDDIL-----------TIL G_gallus_ENSGALP00000013506 PQ--------------------S--------------------TSP-SESIPEEADFLLGMATID--GYASFRHVQEGTWYIQALCSKLQLLVPS-----RGEDIL-----------SIL C_intestinalis_ENSCINP00000025743 ----------------------E--------------------KTE-LKLIPCQADFLIASSTPE--GYSSWRNKANGSWFIQALYLCIQRY--------PSLEIM-----------QIM G_aculeatus_ENSGACP00000005791 ----CS--------------D-A--------------------FKA-SDAIPSEADFLLGMSTVP--SFVSYRHRKNGSWFIESLCQNLVQMVP------K----L-------------- A_carolinensis_ENSACAP00000001629 ----------------------L--------------------QQM-ISSIPEEADFLLGMATVD--GYLSFRHVHQGTWYIQALCDKLRTLVP------RGEDIL-----------SIL D_rerio_ENSDARP00000075318 --------------------K-P--------------------GRV-SVSIPKDSDFLIARSTVE--GYVSIRDRTSGTWFIQSLCENLKEGSK------RGHDIL-----------MIL M_domestica_ENSMODP00000036247 ---LEA--------------D-K--------------------SFQ-SECIPNEADFLLGMATVE--NYVSYRDSARGTWYIQSLCKNLKEGCL------RGNDIL-----------TIL P_troglodytes_ENSPTRP00000021879 ---LEM--------------DLS--------------------SPQ-TRYIPDEADFLLGMATVN--NCVSYRNPAEGTWYIQSLCQSLRERCP------RGDDIL-----------TIL C_intestinalis_ENSCINP00000011503 --------------------E-Q--------------------TTT-VFTIPAEADFLIAHATPE--EFCAWRNRREGSRFIKALCGCLDRYAG------DDIELL-----------QIL H_sapiens_ENSP00000351273 ---LEM--------------DLS--------------------SPQ-TRYIPDEADFLLGMATVN--NCVSYRNPAEGTWYIQSLCQSLRERCP------RGDDIL-----------TIL D_rerio_ENSDARP00000075645 YEE-----------------DAH--------------------AAG-NYSIPMDADFLFAIATVE--HFRSYRHITNGSIFIQVLCKQLERGCA------QKKDIL-----------SIL M_musculus_ENSMUSP00000027189 ---LEV--------------D-S--------------------SSH-KNYIPDEADFLLGMATVK--NCVSYRDPVNGTWYIQSLCQSLRERCP------QGDDIL-----------SIL R_norvegicus_ENSRNOP00000016613 ---LEE--------------D-S--------------------SSY-KNYIPDEADFLLGMATVK--NCVSYRDPTRGTWYIQSLCQSLRERCP------RGEDIL-----------SIL P_pygmaeus_ENSPPYP00000014606 ---LEM--------------DLS--------------------SPQ-TRYIPDEADFLLGMATVN--NCVSYRNPAEGTWYIQSLCQSLKERCP------RGDDIL-----------TIL D_rerio_ENSDARP00000063081 EV------------------D-G--------------------DDF-DITIPSDTDFLIARSTTD--GHVSYRKPDEGSWFIQSLCRNLEKHCP------LGADIL-----------TIL G_aculeatus_ENSGACP00000024809 ----------------------D--------------------GQT-PSRIPVEADFLYAYSTTP--GFNAWRDTQNGSWFMQSLCEMLRRFS-------GQLELM-----------QIM H_sapiens_ENSP00000286186 ----------------------P--------------------TSL-QDSIPAEADFLLGLATVP--GYVSFRHVEEGSWYIQSLCNHLKKLVP------RHEDIL-----------SIL D_rerio_ENSDARP00000075650 --------------------VEG--------------------DNL-DITIPSDTDFLIARSTTN--GHVSYRHVREGSWFIQSLCRNLEKHCP------RGADIL-----------TIL O_anatinus_ENSOANP00000006351 ASPAEP--------------D-A--------------------VFH-ERCIPDEADFLLGMATVS--NCVSYRIPSKGTWYIQSLCHHLRNLCP------LGADIL-----------TIL T_guttata_ENSTGUP00000010625 ---LER--------------D-A--------------------RFQ-LDCIPAEADFLLGMATLQ--DYVSYRSPKEGTWYIQALCQHLEYSCP------RGEDVL-----------TIL E_caballus_ENSECAP00000004055 ---LEM--------------D-S--------------------SFQ-KRCIPDEADFLLGMATVN--NCVSYRNPLEGTWYIQSLCQSLRERCP------RGEDIL-----------TIL O_cuniculus_ENSOCUP00000006164 --------------------D-S--------------------SFP-KRYVPDEADFLLGMATVN--NCVSYRNLFEGTWYIQSLCQSLRERCP------QGEDIL-----------SIL T_rubripes_ENSTRUP00000044662 ----DN--------------N-A--------------------VQA-KECIPSHADFLLGMATVP--SFVSFRDGTHGTWYIQSLCQNLADMVP------RGCDLI-----------SIL C_familiaris_ENSCAFP00000017899 ---LEM--------------D-S--------------------SYQ-KRYIPEDADFLLGMATVN--NCVSYRNPMEGTWYIQSLCQSLRERCP------RGEDIL-----------TIL P_pygmaeus_ENSPPYP00000014602 ----------------------P--------------------TSL-QDSIPAEADFLLGLATVP--GYVSFRHVEEGSWYIQSLCNHLKKLVP------RHEDIL-----------SIL M_mulatta_ENSMMUP00000037898 ----------------------P--------------------TSL-QDSIPVEADFLLGLATVP--GYVSFRHVEEGSWYIQSLCNHL------------------------------- D_rerio_ENSDARP00000024255 ----AS--------------D-A--------------------GVP-RDSIPEMADYLMAMSTVP--WYASYRDKSKGTWFIQSLCDNLRLLVP------RGNDLL-----------SIL M_musculus_ENSMUSP00000030747 DSEPDAVPYQEGPRPL----D-Q--------------------LDA-VSSLPTPSDILVSYSTFP--GFVSWRDKKSGSWYIETLDGILEQWA-------RSEDLQ-----------SLL E_caballus_ENSECAP00000021726 ----------------------T--------------------PSL-EDSVPVEADFLLGLATVP--GYVSFRHVKEGSWYIQSLYNNLKDLVP------RREDIL-----------SIL G_gorilla_ENSGGOP00000000205 ---LEM--------------DLS--------------------SPQ-TRYIPDEADFLLGMATVN--NCVSYRNPAEGTWYIQSLCQSLRERCP------RGDDIL-----------TIL X_tropicalis_ENSXETP00000008971 -------------------------------------------KKY-VVNVPKDADFLLGMSTVD--GYAAYRHTREGSWYIQALCKNLVELVP------RGEDIL-----------AIL T_rubripes_ENSTRUP00000045375 HDQTDAIPMSSSSDSLS-MSD-E--------------------PDA-RASLPTPSDILVSYSTFP--GYVSWRDTQSGSWYIETLDRILEENA-------ATDDLV-----------TML P_troglodytes_ENSPTRP00000048878 ----------------------P--------------------TSL-QDSIPAEADFLLGLATVP--GYVSFRHVEEGSWYIQSLCNHLKKLVP------RMLKFLEKTMEIRGRKRTVW M_domestica_ENSMODP00000005512 ----------------------E--------------------DIA-CQKIPVEADFLYAYSTAP--GSYSWGNSKGGWWFIQALCA----HA-------HEFEIM-----------QIL O_cuniculus_ENSOCUP00000011835 XXXXXX--------------X-X--------------------XXX-XXXLPAGADFLMCYSVAE--GYYSHRETVNGSWYIQDLCEMLGKYG-------SSLEFT-----------ELL T_guttata_ENSTGUP00000014729 ET--------------------D--------------------ANP-RYKIPVEADFLFAYSTVP--GYYSWRNPGRGSWFVQSLCSVLNEHG-------KQLEIM-----------QIL M_domestica_ENSMODP00000004412 DPETDATPFQNNF-------D-Q--------------------PDA-VASLPTPSDILVSYSTFP--GFVSWRDPKSGSWYIETLDRVLEEWA-------DREDLL-----------HML B_taurus_ENSBTAP00000038128 ---LEV--------------D-S--------------------SPQ-KRYIPDEADFLLGMATVK--NYVSYRNIWNGAWYIQSLCQNLRERCP------RGEDIL-----------TIL G_gallus_ENSGALP00000013571 --------------------D----------------------AIP-ALSIPDQADVLVGMATVE--DFECYRSIETGSVYIQCLCDKMELLCP------LRKDLI-----------TIL B_taurus_ENSBTAP00000003205 DPEADATPFQEGPRSI----D-E--------------------PDA-VSSLPTPSDILVSYSTFP--GFVSWRDPKSGSWYIETLDSIFEQWA-------HCEDLQ-----------TLL T_nigroviridis_ENSTNIP00000013855 DDQTDAIPVSSSSDSLS-MSD-E--------------------PDA-RASLPTSSDILVSYSTFP--GYVSWRDPKAGSWYVETLDRVLEENA-------ALHDLV-----------VML O_cuniculus_ENSOCUP00000003895 ----------------------P--------------------PSL-QDSIPVEADFLLGLATVP--GYASLRHVENGSWYIQSLCNHLKALVP-------HEDIL-----------SIL M_domestica_ENSMODP00000036251 ----------------------V--------------------ETP-QRYIPVEADFLLGMATVD--GCCAIRHTIKGSWYIQALCHRLKCMVP------RNEDIL-----------TIL O_latipes_ENSORLP00000005993 ET--------------------D--------------------ANP-SHKIPVEADFLFAYS---------------------------------------------------------- G_aculeatus_ENSGACP00000007379 DDQTDAIPMSSSSDSLS-LSD-E--------------------VDA-RATLPTPSDILVSYSTFP--GYVSWRDTQSGSWYVETLDQVLEQNA-------ATDDLV-----------TML R_norvegicus_ENSRNOP00000017972 DSEPDAVPYQEGPRTL----D-Q--------------------LDA-VSSLPTPSDILVSYSTFP--GFVSWRDKKSGSWYIETLDGVLEQWA-------RSEDLQ-----------SLL T_guttata_ENSTGUP00000017449 SLESDAIPFRVPSDNV----D-E--------------------PDA-IASLPTPSDILVSYSTFP--GFVSWREKSSGSWYVETLDSVLEQYA-------HSEDLL-----------SML O_anatinus_ENSOANP00000015596 DPESDAAPFQAAPEDY----D-E--------------------PDA-VASLPTPSDILVSYSTFP--GFVSWRDTQSGSWYIETLDSVLDQWA-------HTEDLL-----------TLL G_gallus_ENSGALP00000002083 SIESDAIPFQAPSGNE----D-E--------------------PDA-VASLPTPGDILVSYSTFP--GFVSWRDKVSGSWYVETLDSVLEHYA-------RSEDLL-----------TML T_guttata_ENSTGUP00000010628 QE--------------------S--------------------VSL-SESIPEEADFLLGMATVD--GCVAFRHIEEGSWYIQALCSKLQLLVP------RGEDIL-----------SIL C_intestinalis_ENSCINP00000024485 ----------------------A--------------------SHG-RQVLPSESDFLIGHSTVP--GYLSYRSRTDGSWFISTLVDSLEKYH-------EKEDLL-----------SIM C_elegans_C48D1.2 WDNRDGPLFNFLGCVRP-QV-----------------------QQV-WRKKPSQADILIAYATTA--QYVSWRNSARGSWFIQAVCEVFSTHA-------KDMDVV-----------ELL C_intestinalis_ENSCINP00000028692 -DVLDR--------------NPS--------------------KVE-SYTIPVQADFLISQATAP--DYYAWRSSDKGSIFIQTLCSVFERYSD-------------------------- T_rubripes_ENSTRUP00000024467 ESQLEE--------------DAG--------------------PVK-AKVVADSADFLIGMATVE--DYKSFRNTKNGSIYIQELCNQLQKSAESP----GHDHIL-----------DIL M_mulatta_ENSMMUP00000040583 NPEPDATPFQEDLRTF----D-Q--------------------LDA-VSSLPTPSDIFVSYSTFP--GFVSLRDPKSGSWYIETLDNIFEQWA-------HSEDLQ-----------SLL R_norvegicus_ENSRNOP00000040783 ----------------------D--------------------GMS-CQKIPVEANFLYVYSTKP--NYYSW------SWFIHSLCTMLQLCT-------HKLEFM-----------HIL C_familiaris_ENSCAFP00000023986 DSEPDAVPFQEGPGPF----D-Q--------------------LDA-VSSLPTPSDIFVSYSTFP--GFVSWRNTKSGSWYVETLDGVFEQWA-------HAEDLQ-----------TLL E_caballus_ENSECAP00000015102 DSEPDAVPFQEGPGTF----D-Q--------------------PDA-VSSLPTPSDIFVSYSTFP--GFVSWRDPKSGSWYVETLDGVFEQWA-------HSEDLQ-----------TLL D_rerio_ENSDARP00000047019 DDEMDAIPMSSSSDSLSTASD-E--------------------LDA-RASLPTPSDILVSYSTFP--GYVSWRDTEAGSWYVENLDRVLEENA-------ITDDLV-----------TML P_troglodytes_ENSPTRP00000056642 NPEPDATPFQEGLRTF----D-Q--------------------LDA-ISSLPTPSDIFVSYSTFP--GFVSWRDPKSGSWYVETLDDIFEQWA-------HSEDLQ-----------SLL 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0082755 TAVNRKVAYEY---QSNTKN-EALNQMKEMPNFMSTLTKTFQLRVK--PKT--------------------------------------------------------------------- A_aegypti_AAEL003444-PA TGVSRRTAYEF---QSFVPHNAKMDAMKQIPCIVSMLTKTFYFTKK--TRSRVVTDID-------------------------------------------------------------- A_gambiae_AGAP011951-PA TAVSRRVAYHY---QSNVPDNAKIDAKKQMPCMVSMLTKLLYLRPK--K----------------------------------------------------------------------- A_gambiae_AGAP011952-PA TSVSRRVAYLY---ESNVPGNEQMDGKKQMPCVVSMLTKALYFPRK-------------------------------------------------------------------------- A_gambiae_AGAP004920-PA TSVSRRVAYEF---QSNVPNNSQIDCQKQMPCIVSMLTRRIYFSKK-------------------------------------------------------------------------- A_gambiae_AGAP004921-PA TGVSRRVAYDY---QSNEPSKGRMDAMKQMPSIVSMLTKLVYFPLK---------------------------------------------------L---------------------- A_gambiae_AGAP000830-PA TFVTQRVAYDF---ESNTPDIPMMHQQKQIPCTTSMLTRLVYFNQK--K----------------------------------------------------------------------- A_aegypti_AAEL003439-PA TGVSRRALYTC---ESSVPHNEKDNALKPIPCVVSMLTKTFFFTKK--T----------------------------------------------------------------------- A_gambiae_AGAP011949-PA TQVSYIVSCQT---S----ITSDGETVKQIPSINSMLTKAFYFVPK--QTQQIS------------------------------------------------------------------ M_domestica_ENSMODP00000005556 TRVNRKVATEF---ESYSLD-ISFHAKKQVPCIMSMLTKELYFSH--------------------------------------------------------------------------- X_tropicalis_ENSXETP00000003217 TCVNHMVALEF---ESCSTQ-QAFHAKKQIPCVVSMLTKAFYFLK--------------------------------------------------------------------------- A_carolinensis_ENSACAP00000009923 TMVNYKVARNY---ESQSDD-PRFSQKKQVPCVVSMLTKELYF----------------------------------------------------------------------------- A_carolinensis_ENSACAP00000002670 TRVNRKVT-EF---TSCSNH-PDFHGKKQIPCIMSMLTKDFYFPH--------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000005216 TRVNDRVARHF---ESQSDD-PRFHEKKQIPCVVSMLTKELYFSQ--------------------------------------------------------------------------- H_sapiens_ENSP00000358327 TRVNDRVARHF---ESQSDD-PHFHEKKQIPCVVSMLTKELYFSQ--------------------------------------------------------------------------- D_melanogaster_FBpp0071971 TFVNQRVALDF---ESNVPATPMMDRQKQIPCLTSMLTRILRFGDK--PNGNKAG----------------------------------------------------------------- O_cuniculus_ENSOCUP00000009498 TRVNDRVARHF---ESQSDD-PRFNEKKQIPCVVSMLTKELYFCR--------------------------------------------------------------------------- G_gallus_ENSGALP00000014503 TRVNYVVATNF---ESQSDD-PRFSEKKQIPCVVSMLTKELYF----------------------------------------------------------------------------- O_anatinus_ENSOANP00000000517 TRVNRKVATEF---ESYSLD-ATFNAKKQIPCIVSMLTKELYFPY--------------------------------------------------------------------------- M_mulatta_ENSMMUP00000001627 TRVNDRVARHF---ESQSDD-PCFHEKKQIPCVVSMLTKELYFSH--------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000003106 TRVNDRVARHF---ESQSDD-PRFHEKKQIPCVVSMLTKELYFSQ--------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000022693 TRVNDRVARHF---ESQSDD-PRFNEKKQIPCMVSMLTKELYFGR--------------------------------------------------------------------------- G_gallus_ENSGALP00000017288 TRVNRRVA-EY---ESCSTR-QDFNAKKQIPCIVSMLTKEFYFPC--------------------------------------------------------------------------- B_taurus_ENSBTAP00000008706 TRVNDRVARHF---ESQSDD-PRFHEKKQIPCVVSMLTKELYF----------------------------------------------------------------------------- A_gambiae_AGAP011950-PA THVSYLVSVRSFLMESEVNMVKRTGVLKQIPSINSMLTKAFYFVDK-------------------------------------------------------------------------- E_caballus_ENSECAP00000013731 TRVNHRVARHF---ESHSDD-PRFHQKKQIPCVVSMLTKELYF----------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000017020 TRVNRKVATEF---ESFSLD-ATFHAKKQIPCIVSMLTKELYFYH--------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000022078 TRVNYMVATSF---ESWSED-PRFSEKKQIPCVVSMLTKELYFKPC-------------------------------------------------------------------------- D_melanogaster_FBpp0084848 TFVCQRVAVDF---ESCTPDTPEMHQQKQIPCITTMLTRILRFSDK--QLAPAGRV---------------------------------------------------------------- P_troglodytes_ENSPTRP00000054330 TRVNRKVATEF---ESFSFD-ATFHAKKQIPCIVSMLTKELYFYH--------------------------------------------------------------------------- H_sapiens_ENSP00000311032 TRVNRKVATEF---ESFSFD-ATFHAKKQIPCIVSMLTKELYFYH--------------------------------------------------------------------------- X_tropicalis_ENSXETP00000035938 TRVNYLVATQF---ESYCDD-PQFNKKKQIPCVVSMLTKELYFKPC-------------------------------------------------------------------------- G_gorilla_ENSGGOP00000007184 TRVNDRVARHF---ESQSDD-PRFHEKKQIPCVVSMLTKELYFSQ--------------------------------------------------------------------------- T_guttata_ENSTGUP00000006879 TRVNRRVA-EY---ESCSTR-QDFNAKKQIPCIVSMLTKEFYFPS--------------------------------------------------------------------------- G_aculeatus_ENSGACP00000008661 TRVNYMVATSF---ESWSED-PRFSEKKQIPCVVSMLTKELYFN---------------------------------------------------------------------------- C_familiaris_ENSCAFP00000016420 TRVNNRVARHF---ESQSDD-PHFHEKKQIPCVVSMLTKELYF----------------------------------------------------------------------------- M_musculus_ENSMUSP00000026062 TRVNDRVARHF---ESQSDD-PRFNEKKQIPCMVSMLTKELYFSR--------------------------------------------------------------------------- M_musculus_ENSMUSP00000091238 TRVNRKVATEF---ESFSLD-STFHAKKQIPCIVSMLTKELYFYH--------------------------------------------------------------------------- A_gambiae_AGAP012945-PA TSVSRRVAYEF---QSNVPN---------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000015808 TRVNRKVATEF---ESFSLD-ATFHAKKQIPCIVSMLTKELYFYH--------------------------------------------------------------------------- T_rubripes_ENSTRUP00000031759 TRVNYMVATSF---ESWSED-PRFSEKKQIPCVVSMLTKELYFKQC-------------------------------------------------------------------------- B_taurus_ENSBTAP00000021099 TRVNRKVAIEY---ESFSTD-SAFHAKKQIPCIMSMLTKELYF----------------------------------------------------------------------------- E_caballus_ENSECAP00000019797 TRVNRKVAMEF---ESYCLD-PTFHGKKQIPCIVSMLTKELYFYH--------------------------------------------------------------------------- D_rerio_ENSDARP00000019984 TRVNYMVATSF---ESWSED-PRFSEKKQIPCVVSMLTKELYFN---------------------------------------------------------------------------- C_familiaris_ENSCAFP00000032189 TRVNRKVATEF---ESFSLD-SAFHGKKQIPCIVSMLTKELYLYH--------------------------------------------------------------------------- A_gambiae_AGAP009832-PA TFVTQKVAYDH---ESVSNM-PEYNMRKQTPCVVSMLTRLLLFNVV-------------------------------------------------------------------------- T_guttata_ENSTGUP00000011206 TRVNYVVATNF---ESQSDD-PRFSEKKQIPCVVSMLTKELYF----------------------------------------------------------------------------- M_domestica_ENSMODP00000005560 TRVNRKVATEF---ESYSSK-ASLHAKKQMPCIMSMLTKELYFSH--------------------------------------------------------------------------- O_anatinus_ENSOANP00000002508 TRVNHQVAINF---ESQASD-PRYCQKKQIPCLVSMLTKELYF----------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000014096 TRVNRKVATEF---ESFSLD-ATFHAKKQIPCIVSMLTKELYFYH--------------------------------------------------------------------------- T_guttata_ENSTGUP00000004278 TVVNRKVSCRR---VGMCKD-INAIGKKQIPCFASMLTKKLYFHPK--SK---------------------------------------------------------------------- G_aculeatus_ENSGACP00000023055 TLVNRKVSMRS---VGNSSD-RSAIGKKQVPCFASMLTKKLYFRPK--Q----------------------------------------------------------------------- D_rerio_ENSDARP00000071815 TRVNHKVALEF---ESSSNL-PGFDGKKQIPCIVSMLTKELYFPK--------------------------------------------------------------------------- A_carolinensis_ENSACAP00000012644 TLVNRKVSHRE---VDVCKD-RKALGKKQIPCFASMLTKKLYFRPK--FK---------------------------------------------------------------------- G_gallus_ENSGALP00000019870 TVVNRKVSHRK---VDICRD-INAIGKKQIPCFASMLTKKLYFHPK--SK---------------------------------------------------------------------- A_gambiae_AGAP012544-PA CHVSYLVSIRS---DQTID--PEGKVVKQIPMVTSMLTKAFYFVPK-------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000009934 TRVNHKVAVEF---ESDSSL-PGFNAKKQIPCIVSMLTKEMYFS---------------------------------------------------------------------------- O_latipes_ENSORLP00000010095 TRVNHMVAVEF---ESISTL-PGFHAKKQIPCIVSMLTKEMYFYP--------------------------------------------------------------------------- C_intestinalis_ENSCINP00000003204 TVVNRKVSARR---VERSYS-QQALGKKQMPCYLSMLTKKLYLTPK--K----------------------------------------------------------------------- D_rerio_ENSDARP00000093958 TLVNRKVSLRS---I--CDD-LSATGTKQMPCFASMLTKRLFFRPK--K----------------------------------------------------------------------- A_aegypti_AAEL014348-PA TFVVQKVAYGY---ESYAPVHPDHHMKKQTPCVVSMLTRLLLFNNV-------------------------------------------------------------------------- O_anatinus_ENSOANP00000005811 TLVNRKVSYRR---VDFCKD-PSLIGKKQVPCFASMLTKKLHFLPK--AQ---------------------------------------------------------------------- M_domestica_ENSMODP00000007353 TLVNRKVSQRR---VDFCKD-PNAIGKKQVPCFASMLTKKLYLFPK--PK---------------------------------------------------------------------- C_intestinalis_ENSCINP00000011493 TKVNRMVAYDY---ESASKD-PKMNQKKQIPSITTQLTAELYFPKK--REGHPSASEYSVNQQVTSPRQLQHNQVTARCEYDQYSSHTVRASDNAFVETTTQFSRLAMQAGDASRLEEAY D_rerio_ENSDARP00000006831 TRVNHKVALDF---ESTSNM-PGFDAKKQIPCIVSMLTKEMYFTP--------------------------------------------------------------------------- D_rerio_ENSDARP00000041413 TLVNMKVSLRS---VPNCRN-RAAIGKKQMPCFASMLTKRLFFRDN--TQIQ-------------------------------------------------------------------- M_musculus_ENSMUSP00000029626 TLVNRKVSQRR---VDFCKD-PDAIGKKQVPCFASMLTKKLHFCPK--PSK--------------------------------------------------------------------- X_tropicalis_ENSXETP00000052017 TLVNRKVSQRS---VAFCND-PKAIGKKQIPCFSSMLTKKLFLKPK--SN---------------------------------------------------------------------- R_norvegicus_ENSRNOP00000013049 TLVNRKVSQRR---VDFCKD-PGAIGKKQVPCFASMLTKKLHFCPK--PSK--------------------------------------------------------------------- D_rerio_ENSDARP00000050929 TLVNRKVSLRS---VLNCKD-RSAVGKKQVPCFASMLTKKLFFRPK--K----------------------------------------------------------------------- T_rubripes_ENSTRUP00000022652 TLVNRKVSMRS---VGYCSD-PNAIGKKQVPCFASMLTKKLYFRPK--K----------------------------------------------------------------------- H_sapiens_ENSP00000265164 TLVNRKVSQRR---VDFCKD-PSAIGKKQVPCFASMLTKKLHFFPK--SN---------------------------------------------------------------------- T_rubripes_ENSTRUP00000040691 TRVNHKVAVDF---ESVSNL-PGFDAKKQIPCIVSMLTKEMYFS---------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000016744 TLVNRKVSQRR---VDFCKD-PSAIGKKQVPCFASMLTKKLHFFPK--SN---------------------------------------------------------------------- A_gambiae_AGAP004922-PA TGVSRRVAYDY---QSNVPCKGRMDAMKQMPSIVSMLTKLVYFPLK---------------------------------------------------L---------------------- E_caballus_ENSECAP00000013268 TLVNRKVSQRR---VDFCKD-PSAIGKKQVPCFASMLTKKLHFFPK--SK---------------------------------------------------------------------- G_aculeatus_ENSGACP00000022402 VRVNHKVAVAF---ESVSNS-PDFNARKQIPCVVSMLTKEMYFSP--------------------------------------------------------------------------- D_rerio_ENSDARP00000072390 TRVNHLVAYYF---QSYTLE-LETNRKRQMPCFASRLTKDFYLHV--------------------------------------------------------------------------- G_aculeatus_ENSGACP00000024812 TRVNYEVALHF---ESSSDK-LGYSGKKQIPCIMSMLTKDFYFPK--------------------------------------------------------------------------- B_taurus_ENSBTAP00000016642 TLVNRKVSQRR---VDFCRD-PNAIGKKQVPCFASMLTKKLHFSPK--SK---------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000021186 TLVNRKVSMRS---VGYCRD-PNAIGKKQVPCFASMLTKKLYFRPK--KKSK-------------------------------------------------------------------- P_troglodytes_ENSPTRP00000028104 TLVNRKVSQRR---VDFCKD-PSAIGKKQVPCFASMLTKKLHFFPK--SN---------------------------------------------------------------------- A_aegypti_AAEL012143-PA TFVAQRVAYDF---ESNTPDIPMMHQQKQIPCVTTMLTRLLRFTEK-------------------------------------------------------------------------- O_latipes_ENSORLP00000010793 TRVNHKVATHF---ESSSNA-PGFSGKKQIPCIVSMLTKDFYFPYESN------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024816 TRLNHRVALHF---ESSSDT-PGYSGKKQIPCIVSMLTKDFYFPK--------------------------------------------------------------------------- O_anatinus_ENSOANP00000005531 TAVNDDVSQRA---D-------HLGKKKQMPQPAFTLRRKLVFP---------------------------------------------------------------------------- C_familiaris_ENSCAFP00000016791 TLVNRKVSQRR---VDFCKD-PNAIGKKQVPCFASMLTKKLHFFPK--SK---------------------------------------------------------------------- G_gallus_ENSGALP00000013591 TAVNQEVSSKI---D-------KQNAGKQMPQPSFTLRKKLIFPVN-------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000001216 TKVNEDVSKKN---D-------NTGDRKQMPQPVFTITKRIVFPVP-----SGPAPVLPHFPFVEDSP---------------------------------------------------- C_familiaris_ENSCAFP00000017933 TAVNNDVSQQA---D-------KQGTMKQMPQPAYTLRKKLVFPVP-----QKEL--------LL------------------------------------------------------- M_mulatta_ENSMMUP00000037892 TEVNYEVSNKD---D-------KKNMGKQMPQPTFTLRKKLVFPSD-------------------------------------------------------------------------- G_gallus_ENSGALP00000013506 TEVNEDVSKRV---D-------RYGTRKQMPQPAYTLRRKLIFPIP-----RDPP--------PS------------------------------------------------------- C_intestinalis_ENSCINP00000025743 TRVNRMVALHF---E--NTNTESPDIYKQIPSICTRLTGELYFHKP--GST--------------------------------------------------------------------- G_aculeatus_ENSGACP00000005791 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001629 TEVNADVSRRA---D-------AQGQKKQMPQPAYTLRKKLIFPIP-------------------------------------------------------------------------- D_rerio_ENSDARP00000075318 TKVNNDVSRKE---GSLKVK-NEIVDAKVTPQPIFTLRKLLIFRPL--KKTGRFS----------------------------------------------------------------- M_domestica_ENSMODP00000036247 TEVNSEVSQKT---D-------PKNNGKQMPQPKITLRKKLVFPIS-------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000021879 TEVNYEVSNKD---D-------KKNMGKQMPQPTFTLRKKLVFPSD-------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011503 TVVNHHVSHGW---D---GEVYKYEKSKQIPSITTQLTAQLFFTKK--SKNKICQEKPQGTIKENENANAQANDDFIAHEGQETEKEISRPIPSPRHKKTET------------------ H_sapiens_ENSP00000351273 TEVNYEVSNKD---D-------KKNMGKQMPQPTFTLRKKLVFPSD-------------------------------------------------------------------------- D_rerio_ENSDARP00000075645 TAVNGVVGSKI---L---------QGYKQMPEVRYTLTKALVLPMN--GVS--------------------------------------------------------------------- M_musculus_ENSMUSP00000027189 TGVNYDVSNKD---D-------RRNKGKQMPQPTFTLRKKLFFPP--------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000016613 TGVNYDVSNKD---N-------PRNMGKQMPQPIFTLRKKLFFPPN-------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000014606 TEVNYEVSNKD---D-------KKNMGKQMPQPTFTLRKKLVFPSD-------------------------------------------------------------------------- D_rerio_ENSDARP00000063081 LSVNNEVSIQG-------------LHSKQMPVHEVAMRMKLILPPV--NN---------------------------------------------------------------------- G_aculeatus_ENSGACP00000024809 TRVNNKVALEY---KTT----PGRSGKRQMPCIVSLLTKEFYFP---------------------------------------------------------------------------- H_sapiens_ENSP00000286186 TAVNDDVSRRV---D-------KQGTKKQMPQPAFTLRKKLVFPVP-----LDAL--------SL------------------------------------------------------- D_rerio_ENSDARP00000075650 LYVNNEVSSQK-------------SIRKQMPIYEVALTRKLFLRPV--NP---------------------------------------------------------------------- O_anatinus_ENSOANP00000006351 TKVNFEVSQKI---D-------LTNRGKQMPQPMFTLRKKLVLPLL-------------------------------------------------------------------------- T_guttata_ENSTGUP00000010625 TAVNQEVSKKT---C-------ERDAKKQMPQPSFTLRKRLIFPVN-------------------------------------------------------------------------- E_caballus_ENSECAP00000004055 TNVNFEVSSKD---D-------KKNMGKQMPQPTFTLRKRLVFPLN-------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000006164 TKVNYKVSIKE-----------AGEKKKQMPQPTFTLTKRLLFPLD-------------------------------------------------------------------------- T_rubripes_ENSTRUP00000044662 TKVNADVSKKV---A-----WIDSGHKTQMPQPAFTLTKKIVFPAP-----NTPHPV--------------------------------------------------------------- C_familiaris_ENSCAFP00000017899 TEVNFEVSNKD---D-------RKNMGKQMPQPTFTLRKKLFFPPN-------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000014602 TAVNDDVSRRV---D-------KQGTKKQMPQPAFTLRKKLVFPVP-----LDAL--------SL------------------------------------------------------- M_mulatta_ENSMMUP00000037898 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000024255 TKVNADVSKKS---D-------KSGLKKQMPQPEFSLTRTVVFPPP-----GLP------------------------------------------------------------------ M_musculus_ENSMUSP00000030747 LRVANAVSAK--------------GTYKQIPGCFNFLRKKLFFKTS-------------------------------------------------------------------------- E_caballus_ENSECAP00000021726 TAVNDDVSRQV---D-------IYGKKKQMPQPAFTLRKKLVFPVP-------------------------------------------------------------------------- G_gorilla_ENSGGOP00000000205 TEVNYEVSNKD---D-------KKNMG--------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000008971 TKVNKDVSLKE---G-------QQGILKQMPQPSYTLLKKLRFPVP--DVPFRPKTCQENSP---------------------------------------------------------- T_rubripes_ENSTRUP00000045375 MMVNHEVSQN-----------QAKGLYKQMPGSFNFLRKLLYFQS--------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000048878 GAKQTQISATS---L-------PKAISAQTPRPPMHRWSSVS------------------------------------------------------------------------------ M_domestica_ENSMODP00000005512 TRVNGKVATEF---ESYSLD-ISFHAKKQVPCITSILTKKL------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000011835 TLVNRKVSQRR---VDFCKD-PSAIGKKQVPCFASMLTKKLHFFPK-------------------------------------------------------------------------- T_guttata_ENSTGUP00000014729 TRVNYVVATNF---ESQSDD-PRFSEKKQIPCVVSMLTKELYF----------------------------------------------------------------------------- M_domestica_ENSMODP00000004412 LMVSNAVSAR--------------GTYKQIPGCFNFLRKRFFFKTK-------------------------------------------------------------------------- B_taurus_ENSBTAP00000038128 TKVNFEVSKLD---D-------KQRMAKQMPQPTFTLRKKLFFPLN-------------------------------------------------------------------------- G_gallus_ENSGALP00000013571 TEVNKEVGRR------------VLNGWKQMPKITSTLRKQFIFQIP--QCQ--------------------------------------------------------------------- B_taurus_ENSBTAP00000003205 LRVANAVSVK--------------GIYKQMPGCFNFLRKKLFFKT--------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013855 TMVNDEVSQN-----------QAKGLYKQMPGSFNFLRKRLYFIAQP------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000003895 TAVNNDVSRQA---D-------KSGRMRQMPQPAFTLRKRLVFPVP-----QEEP--------SF------------------------------------------------------- M_domestica_ENSMODP00000036251 TEVNNDVSQLT---D-------AEGKKKQMPQPAFTLRKKVVFPVP-----PLSP----------------------------------------------------------------- O_latipes_ENSORLP00000005993 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000007379 MMVNHEVSQN-----------SAKGLYKQMPGSFNFLRKLLHFQTHA------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000017972 LRVANAVSEK--------------GVYKQIPGCFNFLRKKLFFKLH-------------------------------------------------------------------------- T_guttata_ENSTGUP00000017449 VRVAHAVSAR--------------GRYKQIPGCFNFLRKKFFFVCR-------------------------------------------------------------------------- O_anatinus_ENSOANP00000015596 LRVSNGVSSK--------------GKYKQIPGCFNFLRKRLFFNTK-------------------------------------------------------------------------- G_gallus_ENSGALP00000002083 LRVSDIVSTK--------------GRYKQIPGCFNFLRKKFFFLCK-------------------------------------------------------------------------- T_guttata_ENSTGUP00000010628 TQVNEDVARRD---S-------PSGKKKQMPQPAYTLRRKFIFPIP--M----------------------------------------------------------------------- C_intestinalis_ENSCINP00000024485 INVNQEMASK---------------PYKQMPMPIATLRKKVFFSKQ--NSNSSSNQNCNTP----------------------------------------------------------- C_elegans_C48D1.2 TEVNKKVACGF---Q----TSQGSNILKQMPEMTSRLLKKFYFWPE--ARNSAV------------------------------------------------------------------ C_intestinalis_ENSCINP00000028692 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000024467 TRVNREVSEG------------EFLNHKQMPEPKYTLTKKLVLKYL-------------------------------------------------------------------------- M_mulatta_ENSMMUP00000040583 LRVADAVSVK--------------GIYKQMPGCFNFLRKKLFFKTS-------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000040783 THANRKVATEF---KSFSLG-GTFHKKKQIPCILSMLPKELYFYH--------------------------------------------------------------------------- C_familiaris_ENSCAFP00000023986 LRVANAVSQK--------------GVYKQIPGCFNFLRKKLYFKM--------------------------------------------------------------------------- E_caballus_ENSECAP00000015102 LRVAHAVSEK--------------GVYKQIPGCFNFLRKKFFFKTY-------------------------------------------------------------------------- D_rerio_ENSDARP00000047019 MLVNDAVSQI-----------SAKGLYKQMPGSFNFLRKLLYFQSSQS------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000056642 LRVSAAFLCK--------------GEGRLLRGSVSSWGWGFGVSRAGPNQG--------------------------------------------------------------------- 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_melanogaster_FBpp0082755 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003444-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004921-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP000830-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003439-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358327 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0071971 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011950-PA ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0084848 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP012945-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000019984 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009832-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002508 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004278 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000019870 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP012544-PA ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL014348-PA ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000005811 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007353 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011493 MDPRTQGAAANPPSHASVRQRDLFPRPPPLPTKQRQTRRSNDSSHRRSGDYTTRRPPQEVYSSPTGSPRDVTPHYVTGYDAPPRRSSHETSPYGSQHNVARRRPSYETSFPAGSRAIPAV D_rerio_ENSDARP00000006831 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000041413 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000050929 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000265164 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004922-PA ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000016642 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL012143-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000005531 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013591 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000001216 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017933 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037892 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013506 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005791 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001629 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075318 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000036247 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000021879 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011503 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000351273 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075645 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027189 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000016613 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014606 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000063081 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000286186 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075650 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000006351 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010625 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004055 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006164 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000044662 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017899 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014602 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037898 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030747 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000021726 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000205 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000008971 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000045375 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000048878 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005512 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011835 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000014729 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000004412 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000038128 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013571 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000003205 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013855 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003895 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000036251 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000005993 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000007379 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017972 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000017449 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015596 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000002083 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010628 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------------------------------------------------------------------ C_elegans_C48D1.2 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000028692 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000024467 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000040583 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000040783 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023986 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000015102 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000047019 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000056642 ------------------------------------------------------------------------------------------------------------------------ 970 980 990 1000 1010 1020 1030 1040 =========+=========+=========+=========+=========+=========+=========+=========+===== D_melanogaster_FBpp0082755 ------------------------------------------------------------------------------------- A_aegypti_AAEL003444-PA ------------------------------------------------------------------------------------- A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------- A_gambiae_AGAP011952-PA ------------------------------------------------------------------------------------- A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------- A_gambiae_AGAP004921-PA ------------------------------------------------------------------------------GS----- A_gambiae_AGAP000830-PA ------------------------------------------------------------------------------------- A_aegypti_AAEL003439-PA ------------------------------------------------------------------------------------- A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------- M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------------------------------- H_sapiens_ENSP00000358327 ------------------------------------------------------------------------------------- D_melanogaster_FBpp0071971 ------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------------------------------- G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------------------------------- G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------- A_gambiae_AGAP011950-PA ------------------------------------------------------------------------------------- E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------------------------------- D_melanogaster_FBpp0084848 ------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------- H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000026062 ------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------- A_gambiae_AGAP012945-PA ------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------- E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------- D_rerio_ENSDARP00000019984 ------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------------------------------- A_gambiae_AGAP009832-PA ------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------- M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000002508 ------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000004278 ------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------------------------------- D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------------------------------- G_gallus_ENSGALP00000019870 ------------------------------------------------------------------------------------- A_gambiae_AGAP012544-PA ------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------------------------------- O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------------------------------- D_rerio_ENSDARP00000093958 ------------------------------------------------------------------------------------- A_aegypti_AAEL014348-PA ------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000005811 ------------------------------------------------------------------------------------- M_domestica_ENSMODP00000007353 ------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011493 TLRKQSLPVSSMYSSSADSHLLTPNRHLHPSETVPARLSVSPNAARNSVNRRSLPLGTDPKPQAVSSWGSGINRAGLRSTKQTEV D_rerio_ENSDARP00000006831 ------------------------------------------------------------------------------------- D_rerio_ENSDARP00000041413 ------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000029626 ------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------------------------------- D_rerio_ENSDARP00000050929 ------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------------------------------- H_sapiens_ENSP00000265164 ------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------------------------------- A_gambiae_AGAP004922-PA ------------------------------------------------------------------------------GS----- E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------------------------------- D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000016642 ------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000021186 ------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------------------------------- A_aegypti_AAEL012143-PA ------------------------------------------------------------------------------------- O_latipes_ENSORLP00000010793 ------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000005531 ------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------------------------------- G_gallus_ENSGALP00000013591 ------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000001216 ------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000017933 ------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000037892 ------------------------------------------------------------------------------------- G_gallus_ENSGALP00000013506 ------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000005791 ------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000001629 ------------------------------------------------------------------------------------- D_rerio_ENSDARP00000075318 ------------------------------------------------------------------------------------- M_domestica_ENSMODP00000036247 ------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000021879 ------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011503 ----------------------------------------------------------------------------QV------- H_sapiens_ENSP00000351273 ------------------------------------------------------------------------------------- D_rerio_ENSDARP00000075645 ------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000027189 ------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000016613 ------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000014606 ------------------------------------------------------------------------------------- D_rerio_ENSDARP00000063081 ------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------- H_sapiens_ENSP00000286186 ------------------------------------------------------------------------------------- D_rerio_ENSDARP00000075650 ------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000006351 ------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000010625 ------------------------------------------------------------------------------------- E_caballus_ENSECAP00000004055 ------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000006164 ------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000044662 ------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000017899 ------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000014602 ------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000037898 ------------------------------------------------------------------------------------- D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000030747 ------------------------------------------------------------------------------------- E_caballus_ENSECAP00000021726 ------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000000205 ------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000008971 ------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000045375 ------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000048878 ------------------------------------------------------------------------------------- M_domestica_ENSMODP00000005512 ------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000011835 ------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000014729 ------------------------------------------------------------------------------------- M_domestica_ENSMODP00000004412 ------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000038128 ------------------------------------------------------------------------------------- G_gallus_ENSGALP00000013571 ------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000003205 ------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013855 ------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000003895 ------------------------------------------------------------------------------------- M_domestica_ENSMODP00000036251 ------------------------------------------------------------------------------------- O_latipes_ENSORLP00000005993 ------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000007379 ------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000017972 ------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000017449 ------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000015596 ------------------------------------------------------------------------------------- G_gallus_ENSGALP00000002083 ------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000010628 ------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------------------------------- C_elegans_C48D1.2 ------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000028692 ------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000024467 ------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000040583 ------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000040783 ------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000023986 ------------------------------------------------------------------------------------- E_caballus_ENSECAP00000015102 ------------------------------------------------------------------------------------- D_rerio_ENSDARP00000047019 ------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000056642 -------------------------------------------------------------------------------------