>C_elegans_C48D1.2 ------------------------------------------------------------ -------------------------------------------MMRQDRRSL----LERN IMM-------------FSSHLKVD--EILEVLIAKQ------------------------ ------------------------------------------------------------ -----------VLNSDNGDMINSCGTVRE---KRREIVKAVQRRGDVAFDAF-------- ------------------------------------------------------------ ---------------------------------------------------YD-ALRSTG HEG-LAEVLEPLARS--------------------------------VDSNAVEFECPMS PASHRRSRALSPAGYTSPTRVHRDSVSSVSSFTSYQDIYSRARSRSRSRALHSSDRHNYS SPPVNAFPSQPSSANSSFTGCSSLGYSSSRNRSFSKASGPTQYIFHE---------EDMN FVDAPTIS----RVFDEKTMYR--NFSSPRGMCLIINNEHFE--Q----------MPTRN GTKA-DKDNLTNLFRCMGYT-VICKDNLTGRGMLLTIRDFAKH---ESHGDSAILVILSH GEE-------NVIIGVDDI----PISTHEIYDLLNAANAPRLANKPKIVFVQACRG---E RR-DNGFPVL--DSVDG-----------VPAFLRRGWDN----RDGPLFNFLGCVRPQVQ QVWRKKP-----SQADILI---AYATTA--Q--YVSWRNSARGSWFIQAVCEVFSTH--- -A---KDMDVV--ELLTEVNKKVACGFQ----TSQGSNILKQMPEMTS-----RLLKKFY FWPEARNSAV----------- >C_elegans_Y48E1B.13a ------------------------------------------------------------ ----------MVLKTIEDNCKSQFDDDLVEDFNNFQTTSSMSSSTTISTEDFNTIEIEST FEICRSGSYTEEPILGENDEFLID--FEMERFLKFLKDKTKQVEKRKEPFSQKEIYA--- ------------------------------------------------------------ -----------VFQRRIKSELCIETVKKKFQPLLPNAIQTCEFDEETMIRMIYGAGIRID SVDFWNR----------------------------------------------------- ---------------------------------------------------FT-SKATIS LDC-YSRLISYSSDS------------------------------------------LTL SGTHRSGFTYHWISTPPVTYHRTENKDPNIQEPSPVEFLDVQSSLGSSMKPPILDKPTKL DDPAETRHDCSYSL------------------------------------------EEYD SQSRMPRTDAKKSNHKHKYCYE--MNSNPRGTVLILSNENFK--N----------MERRV GTKQ-DEVNLTKLFQKLQYT-VICKRNLEAESMLEAIKEFAEM-A-HT--DSIILFLLSH GDGA------GSVFGIDDM----PVNVMEVSTYL--AYHQNLLLKPKWVAVSACRG---G KL-NMGVPVD--G----------------LPALEDKCAPISKFWNL-------------- MMSRIMPGTFTSLNADVII---SFSTTD--G--FTSYRDEEAGTWYIKSMCKVFNKH--- -S---KTMHLL--DILTETGRNVVTKYE----NVQGNVVLKQAPEILS-----RLTKQWH FSRSM---------------- >D_rerio_ENSDARP00000047019 ------------------------------------------------------------ --------------------------------------------MEQKHRQI----LQRH RLN-------------LVKALNPE--DVCDKLLSKG------------------------ ------------------------------------------------------------ -----------VFTQDMIDEIQSK--ATR-RDQARQLVKDLETRGSLAFPAF-------- ------------------------------------------------------------ ---------------------------------------------------LD-SLRETG HND-LAELLQSGDGV-------------------------------------HRPPVISV QPS-PIPLPVQNLNH-----------------TEKPDKPDIASPRLVPLRPESLPVHKTY --------------------------------------------------------SPPS ETVVRPTR----PRRDSIQCYK--MDASPCGVCLIINNINFE--KASE-------LNDRK GSNI-DCDKLEKRFKALNFE-VTVKRNLKSKRIRHEMASLAKK-D-HSTYDCCVVIILSH GTEASHNRFPGAVHGVDGP----AVPIQIITNYLNGQNCPSLQGKPKLFFIQACGG---G EK-DIGFEVS--PDDVQPSIGGIDDEMDAIPMSSSSDSLSTASDEL-------------- DARASLP-----TPSDILV---SYSTFP--G--YVSWRDTEAGSWYVENLDRVLEEN--- -A---ITDDLV--TMLMLVNDAVSQIS--------AKGLYKQMPGSFN-----FLRKLLY FQSSQS--------------- >T_rubripes_ENSTRUP00000045375 ------------------------------------------------------------ --------------------------------------------MEERHKKI----LQRN RTN-------------LVGELDPS--SLYDGLIEKR------------------------ ------------------------------------------------------------ -----------VFTHDMIDEIKSS--GTR-RDQARQLIRDLETRGSRAFPLF-------- ------------------------------------------------------------ ---------------------------------------------------LE-CLQETG HHT-LVELLQDGGPA------------------------------------------VQI QPPTPVPIDRPVIQPLPVCKSAI---------RSRVLRGTMTVKAAPPVDVVRRD----K APVIPVPQPSTAPSPSP---------------------------------------EREY MRLKPQGR----IRRDSIQSYK--MDANPSGHCLIINNVDFE--PRSE-------LNDRK GSNT-DCDRLESRFKALNFI-VKVKTNLKQRQIKHELSALSKM-D-HSQYDCCVVVLLSH GTEVSHSRFPGAVYGVDGQ----FVPVQHITTYLNGQHCPSLQGKPKLFFIQACGG---D EK-DTGFEVS--PDEFEPPVVSAHDQTDAIPMSSSSDSLS-MSDEP-------------- DARASLP-----TPSDILV---SYSTFP--G--YVSWRDTQSGSWYIETLDRILEEN--- -A---ATDDLV--TMLMMVNHEVSQNQ--------AKGLYKQMPGSFN-----FLRKLLY FQS------------------ >O_anatinus_ENSOANP00000002508 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MADDQAPTMHQKECDFEDEVDAKPERLKVAQL---------- ------------------------------------------------------------ ---------------------------------------------------FS-KKKNEA ESQ-SGGPLPVRN----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RVVSSSFIYN--MKYENLGKCIIINNKNFA--SKTG-------MSTRN GTDK-DAGNLQKCFRSLGFD-VSVFNDFSCNQMKEILQKASEE-N-HENSACFACILLSH GEG-------DCIYGTDD-----FIPIKELTILFRGDKCKSLLGKPKLFFIQSCRG---T EF-DDGIQTD--STPVT-D------------------------SDA-------------- NPGCRIP-----VEADFLF---AYSTVPVKG--YYSWRNVDRGSWFVQALCSVLHEH--- -G---KELEIM--QLLTRVNHQVAINFESQA-SDPRYCQKKQIPCLVS-----MLTKELY F-------------------- >C_elegans_Y73B6BL.7 -------------------------MKIGWLLITICSGIITKCINAHSSPYQNANESAID DAYFLVLIIPAVSVAIVLVVVIFLCCPRQQIRSDNVIKLEEGVNDVIEENVTHVVSLREA KVSGMMTDLTRFRQEIFTKHLTFNSNPESIDAATKNVQNVKQSLDTWRDRIKERLDEIDR LCTEEGDSLTPEQYSALREMRRQLADEYDTVLRTVEGIHTRLNILSALLIEFSSVTSSMQ SWMTDRARLAGDIRHKSGDPMRVDEARFEAKSLMDEVVREESRLKTIGASVLKIEQEISA MRDDVRASRSTDDVGISMDEVYEKRRRVEVDYMQLLRQCQDLISLQIRLHAMNDEHAEQA RRAEGWLQMLKNDVAGVAKDPRFKKDEDLIERDEELNRMAAGGSGGPTSRQLA-MREKIE QRE-REEEEWRRKAKEKFEEEAAKNRARERKWAEEHGFNRPIRTRSQKYAEQDRIRYARK KAALEQSNEQSNESTDDAVESDSDDVPAPQSPPTPSPADPGPTTSSSSLTQDPASNATGF SDVPAPQAPPTPSPADPGPTTSSSSLTQDPASNATGFSGSSPPNSFE---------ETRM MCEDASDG----KKIDETRKYR--NNRSSKCRAIIINNVVFC--G----------MEKRI GSDK-DKKKLSKLFERLGYQ-STSYDNLKSSEILETVRQFTQS-N-HG--DSLIITIMSH GDQ-------GLLYGVDGV----PVQMLDIIDLMC---TASLAKKPKWLMCVCCRG---D RI-DRAVRCD--GFIDN---------FFDRFPKFFQFMK----SKF-------------- PSHQTSS-----SQADLLV---SFSTSP--G--FLSFRDETKGTWYIQELYRVIIEN--- -A---KDTHLA--DLLMETNRRVVEKYE----ADKVVIVCKQAPEFWS-----RFTKQLF FDV------------------ >T_nigroviridis_ENSTNIP00000013855 ------------------------------------------------------------ --------------------------------------------MEERHKKI----LQRN RIN-------------LVSELEPL--NLYDGLIEKG------------------------ ------------------------------------------------------------ -----------VFTHDMIDEIKCS--GAR-RDQARQLVRDLETRGSRAFPAF-------- ------------------------------------------------------------ ---------------------------------------------------LE-CLKETG YHS-LAELLQNGAPT------------------------------------------VQI QPPTPIPVDRPVIQPLPISPPLVPP----------------------------------E EPVSPVPKPSTPGRASP---------------------------------------EVEY VTLK--GR----IRRDSLQSYR--MEANPLGHCLIINNVEFE--PKSG-------LSNRN GSNV-DCDRLERRFKALNFT-VKVKTNLKQRQIRQELSALSKV-D-HSQYDCCVVVILSH GTEVSHSRFPGAVYGVDGQ----FVPVQHIATYLNGQYCPSLQGKPKLFFIQACGG---D EK-DTGFQVS--PDEFEPPVVGADDQTDAIPVSSSSDSLS-MSDEP-------------- DARASLP-----TSSDILV---SYSTFP--G--YVSWRDPKAGSWYVETLDRVLEEN--- -A---ALHDLV--VMLTMVNDEVSQNQ--------AKGLYKQMPGSFN-----FLRKRLY FIAQP---------------- >D_rerio_ENSDARP00000006831 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MNGDCVDAKR------------------ ------------------------------------------------------------ ---------------------------------------------------VDTTDASKD GAS-ASQPMQVDA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------KPQSHAFRYS--LNYPNIGHCIIINNKNFD--RRTG-------MNPRN GTDV-DAGNVMNVFRKLGYI-VKVYNDQTVAQIMQVLTTVAHD-D-HSRCASLVCVLLSH GDE-------GVFFGTDT-----SVDLKSLTSLFRGDRCPSLVGKPKLFFIQACRG---T EL-DPGVETD--HPDHP--------------------------DIP-------------- DGRVRIP-----VEADFLY---AYSTVP--G--YYSWRNTMTGSWFIQSLCEMMTKY--- -G---SELELL--QIMTRVNHKVALDFESTS-NMPGFDAKKQIPCIVS-----MLTKEMY FTP------------------ >G_gallus_ENSGALP00000014503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------KKKNG EEE-QPKSSLSNQY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RIVTPTFQYN--MNYKKVGKCIIINNKNFE--DKTG-------MGTRN GTDK-DAGDLSKSFRSLGFD-VYTYNDRSCEDMQTLLKQAAEE-N-HSDAACFACILLSH GEE-------GLIYGTDG-----PMAIKHLTTLFRGDKCKTLIGKPKLFFIQACRG---S EF-DEGIQTD--SGPAN-DTLE---------------------TDA-------------- NPRYKIP-----VEADFLF---AYSTVP--G--YYSWRNPGRGSWFVQSLCSVLNEH--- -G---KQLEIM--QILTRVNYVVATNFESQS-DDPRFSEKKQIPCVVS-----MLTKELY F-------------------- >M_mulatta_ENSMMUP00000016588 ------------------------------------------------------------ -------------------------------------RILGVCGMHPHHQET----LKKN RVM-------------LAKQLLLS--ELLEHLLEKD------------------------ ------------------------------------------------------------ -----------IITLEMRELIQAKVGSFS---QNVELLNLLPKR-PQAFDAF-------- ------------------------------------------------------------ ---------------------------------------------------CE-ALRETK QGH-LEDIELKLRVS---------------AL--------------MKP--------TGL GSDYNDILGLMVKLNT------------------VFWFSVYTT-DTVEHSLDNKDGP--- --------------------------------------------------------VCLQ VKPCTPEF----YQTHFQLAYR--LQSRPRGLALVLSNVHFT--GEKE-------LEFRS GGDV-DHSTLVTLFKLLGYD-VHVLRDQTAQEMQEKLQNFARLPA-HRVTDSCIVALLSH GVE-------GAIYGVDGK----LLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG---D ET-DRGVDQQ--DGKNH----------AGSPGCEESDAG----KEK-------------- LPKMRLP-----TRSDMIC---GYACLK--G--TAAMRNTKRGSWYIEALAQVFSER--- -A---CDMHVA--DMLVKVNALIKDREGYA--PGTEFHRCKEMSEYCS-----TLCRHLY LFPGHPPT------------- >O_latipes_ENSORLP00000003208 ------------------------------------------------------------ --------------------------------------------MEEKHKRI----LRRN RVH-------------LVKELDLS--DLCDVLLRKD------------------------ ------------------------------------------------------------ -----------VFTQSMINDIKRQNCETK-RDQARKLVKDLETRGNEAFSAF-------- ------------------------------------------------------------ ---------------------------------------------------LE-GLRVTG QQN-LLELLQKSAPR------------------------------------------VHF QPGKSTEAGYLLIQPHPVYIEDAVPKKP----RTQPSPRKRERRGGGVKVPHNIFIDKVK SDIFDSKSRFRNNDNTN---------------------------------------VCTH LTRCSRGQ----RSDHDGTASR--MDARPCGLCLIINNVEFE--PKTE-------LSIRK GSNV-DCDKLEKRFKSLNFV-VEVRTNLKQRQIKSELSALSRK-D-HSIYDCCVVVILSH GTEVSHNRFPGAVYGVDGN----HVSVQEITNYLNGQNCPSLQSKPKIFFIQACGG---G EK-DIGFEVS--PDEAKPSIGGDGDQTDAIPFSSSSESLS-TSDET-------------- DAIPTLP-----TPSDILV---SYSTFP--G--YVSWRATVSGSWYVEVLDNILEEH--- -A---ATLDLT--TMLTLVNDKVSQNS--------AKGLYKQMPGSFN-----FLRKHVY FQTS----------------- >H_sapiens_ENSP00000312664 ------------------------------------------------------------ -------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQET----LKKN RVV-------------LAKQLLLS--ELLEHLLEKD------------------------ ------------------------------------------------------------ -----------IITLEMRELIQAKVGSFS---QNVELLNLLPKRGPQAFDAF-------- ------------------------------------------------------------ ---------------------------------------------------CE-ALRETK QGH-LEDMLLTTLSG---------------LQ--------------HVL--------PPL SCDYDLSLPFPVCESC-----------------PLYKKLRLST-DTVEHSLDNKDGP--- --------------------------------------------------------VCLQ VKPCTPEF----YQTHFQLAYR--LQSRPRGLALVLSNVHFT--GEKE-------LEFRS GGDV-DHSTLVTLFKLLGYD-VHVLCDQTAQEMQEKLQNFAQLPA-HRVTDSCIVALLSH GVE-------GAIYGVDGK----LLQLQEVFQLFDNANCPSLQNKPKMFFIQACRG---D ET-DRGVDQQ--DGKNH----------AGSPGCEESDAG----KEK-------------- LPKMRLP-----TRSDMIC---GYACLK--G--TAAMRNTKRGSWYIEALAQVFSER--- -A---CDMHVA--DMLVKVNALIKDREGYA--PGTEFHRCKEMSEYCS-----TLCRHLY LFPGHPPT------------- >P_troglodytes_ENSPTRP00000033921 ------------------------------------------------------------ -------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQET----LKKN RVV-------------LAKQLLLS--ELLEHLLEKD------------------------ ------------------------------------------------------------ -----------IITLEMRELIQAKVGSFS---QNVELLNLLPKRGPQAFDAF-------- ------------------------------------------------------------ ---------------------------------------------------CE-ALRETK QGH-LEDMLLTTLSG---------------LQ--------------HVL--------PPL SCDYDLSLPFPVCESC-----------------PLYKKLRLST-DTVEHSLDNKDGP--- --------------------------------------------------------VCLQ VKPCTPEF----YQTHFQLAYR--LQSRPRGLALVLSNVHFT--GEKE-------LEFRS GGDV-DHSTLVTLFKLLGYD-VHVLCDQTAQEMQEKLQNFAQLPA-HRVTDSCIVALLSH GVE-------GAIYGVDGK----LLQLQEVFQLFDNANCPSLQNKPKMFFIQACRG---D ET-DRGVDQQ--DGKNH----------AGSPGCEESDAG----KEK-------------- LPKMRLP-----TRSDMIC---GYACLK--G--TAAMRNTKRGSWYIEALAQVFSER--- -A---CDMHVA--DMLVKVNALIKDREGYA--PGTEFHRCKEMSEYCS-----TLCRHLY LFPGHPPT------------- >R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MTDDQDCAAELEMADSSTEDGVDAKPDRSTIISSL--------- ------------------------------------------------------------ ---------------------------------------------------LW-KKKKNA SMC-PVSTT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RDRVPTYLYR--MDFEKMGKCIIINNKNFD--KATG-------MDVRN GTDK-DAEALFKCFRSLGFE-VTVYNDCSCAKMQDLLRRASEE-D-HSNSACFACVLLSH GEE-------NLIYGKDG-----VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG---T EL-DDGIQAD--SGPIN-D------------------------TDA-------------- NPRYKIP-----VEADFLF---AYSTVP--G--YYSWRNPGKGSWFVQALCSILNEH--- -G---KDLEIM--QILTRVNDRVARHFESQS-DDPRFNEKKQIPCMVS-----MLTKELY FGR------------------ >G_aculeatus_ENSGACP00000007379 ------------------------------------------------------------ --------------------------------------------MEEIHKRI----LQRN RIN-------------LVRDLDPS--SLYDGLLEKG------------------------ ------------------------------------------------------------ -----------VFTQDMIDEIKSA--GTR-RDQARKLVQDLETRGSRAFAML-------- ------------------------------------------------------------ ---------------------------------------------------LL-CLEETD QHG-LAELLQRAAPA------------------------------------------VQI WPAAPNQPFVLMLNS-----------------REKTTSPSIQYRNPVPVHLTHCD----- -----------AHVTAP---------------------------------------EREN TLTRPPGR----TRRDSIQSYK--MDASPCGHCLIINNVEFE--PDSE-------LSNRK GSNI-DCDKLEKRFKALNFI-VEVRTNLKQRQIKHALSALSKK-D-HSQCDCCVVIMLSH GTEVSHNRFPGAVYGVDGQ----HVPVQLITNYLNGQHCPSLQGKPKLFFIQACGG---G ER-DTGFEVS--PDEVEPSIGGADDQTDAIPMSSSSDSLS-LSDEV-------------- DARATLP-----TPSDILV---SYSTFP--G--YVSWRDTQSGSWYVETLDQVLEQN--- -A---ATDDLV--TMLMMVNHEVSQNS--------AKGLYKQMPGSFN-----FLRKLLH FQTHA---------------- >A_carolinensis_ENSACAP00000006831 ------------------------------------------------------------ ------------------------------------SRMLGVCGMQKCHQEA----LKKN RVS-------------LAKQLVLK--ELMEHLIEKD------------------------ ------------------------------------------------------------ -----------VITEEMMEMIQAKAGNFS---QNIEFLNLLPKRGPKAFSAF-------- ------------------------------------------------------------ ---------------------------------------------------CE-ALRETK QPH-LEEMLLLNLID-------------------------------------FLLFHHVI VPPQNAHLPL--HTVCDLL--------------PFAYQLFISSAEPMEHSLDDGDGP--- --------------------------------------------------------HYPQ VMPCTPEF----YRTHEQLAYK--LKSQPRGLALILSNIHFN--KETD-------LDFRS GGDV-DNTALHMLFKHLGYQ-VVVRQDRTAQEMKEELEIFSKHPA-HRNVDSCIVSLLSH GIE-------GGIYGIDGK----LLQLQEIFRLFDNANCPNLQNKPKMFFVQACRG---D ET-DHGVDQI--DGNDR----------ASSPGCEETDAN----KKE-------------- NPKLRLP-----TCSDMIC---GYACLK--G--TAAMRNTKHGSWYVEALTSVFAED--- -S---GHMHVA--DMLVKVNRLIKLREGHA--PGTEFHRCKEMSEYCS-----TLCQDLY LFPGYFPG------------- >T_guttata_ENSTGUP00000006879 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MTDIGDGAHLGKDLADTKS------------------ ------------------------------------------------------------ -------------------------------------------------------IPGFK GKN-LPASKSMD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SGILPDYSYR--MDYPEMGECIIINNKNFH--RYTG-------MSPRS GTDA-DAASVREVFMKLGYK-IKINNDLSCEGIFNLLKNVSEE-D-HSKRSSFVCVLLSH GDE-------GLIYGTDG-----PLELKALTSLFRGDRCRSLAGKPKFFFIQACRG---T EL-DSGIETD--SGS-----------------------------EE-------------- TMCQKIP-----VEADFLY---AYSTAP--G--YYSWRNSAEGSWFIQSLCKMLKEH--- -A---RKLELM--QILTRVNRRVA-EYESCS-TRQDFNAKKQIPCIVS-----MLTKEFY FPS------------------ >X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MEESHNGVQYGEDTADAKT------------------ ------------------------------------------------------------ ----------------------------------------------------Y-FTNQQI SLQ-NCDIKDMEKK---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------TKFAHLHKYR--TDYPEMGICLIINNKNFQ--SSTN-------MGVRN GTDV-DARKLHETFTGLGYK-VKVCNDQKSNDIFTLLKKMSEE-D-HSKRSSFVCAILSH GED-------GLVYGVDG-----PIQIKNLTDLFRGDRCKTLVGKPKLFFIQACRG---T DL-DSGIETD--SGS----------------------------EPG-------------- EEIQRIP-----VEADFLY---AYSTVP--G--YYSWRNTMNGSWFIQSLCEMIKLY--- -G---PHLELI--QILTCVNHMVALEFESCS-TQQAFHAKKQIPCVVS-----MLTKAFY FLK------------------ >R_norvegicus_ENSRNOP00000022672 ------------------------------------------------------------ -------------MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQET----LKKN RVV-------------LAKQLLLS--ELLEHLLEKD------------------------ ------------------------------------------------------------ -----------IITLEMRELIQAKGGSFS---QNVELLNLLPKRGPQAFDAF-------- ------------------------------------------------------------ ---------------------------------------------------CE-ALRETR QGH-LEDLLLTTLSD---------------IQ--------------HIL--------PPL SCDYDSSLPFSVCESC-----------------PPHKQSRLST-DTMEHSLDNGDGP--- --------------------------------------------------------PCLQ VKPCTPEF----YQAHYQLAYR--LQSQPRGLALVMSNVHFT--GEKD-------LEFRS GGDV-DHTTLVTLFKLLGYN-VHVLYDQTAQEMQEKLQNFAQLPA-HRVTDSCIVALLSH GVE-------GGIYGVDGK----LLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG---D ET-DRGVDQQ--DGKNH----------AQSPGCEESDAG----KEE-------------- LMKMRLP-----TRSDMIC---GYACLK--G--NAAMRNTKRGSWYIEALTQVFSER--- -A---CDMHVA--DMLVKVNALIKEREGYA--PGTEFHRCKEMSEYCS-----TLCQQLY LFPGYPPT------------- >G_gallus_ENSGALP00000017288 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MMTDIKDGPRSGEDVSDARS------------------ ------------------------------------------------------------ -------------------------------------------------------FPGSK GMN-LPASKSVD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SGILPDDSYR--MDYPEIGVCVIINNKNFH--RDTG-------LSSRS GTDA-DAASVREVFMKLGYK-VKLNNDLSSRDIFKLLKNVSEE-D-HSKRSSFVCVLLSH GDE-------GLFYGTDG-----PLELKVLTSLFRGDKCRSLAGKPKLFFIQACRG---T EL-DSGIEAD--SGP-----------------------------DE-------------- TVCQKIP-----VEADFLY---AYSTAP--G--YYSWRNAAEGSWFIQSLCRMLKEH--- -A---RKLELM--QILTRVNRRVA-EYESCS-TRQDFNAKKQIPCIVS-----MLTKEFY FPC------------------ >M_musculus_ENSMUSP00000031895 ------------------------------------------------------------ -------------MAAPSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQET----LKKN RVV-------------LAKQLLLS--ELLEHLLEKD------------------------ ------------------------------------------------------------ -----------IITLEMRELIQAKGGSFS---QNVELLNLLPKRGPQAFDAF-------- ------------------------------------------------------------ ---------------------------------------------------CE-ALRETR QGH-LEDLLLTTLSD---------------IQ--------------HVL--------PPL SCDYDTSLPFSVCESC-----------------PPHKQLRLST-DATEHSLDNGDGP--- --------------------------------------------------------PCLL VKPCTPEF----YQAHYQLAYR--LQSQPRGLALVLSNVHFT--GEKD-------LEFRS GGDV-DHTTLVTLFKLLGYN-VHVLHDQTAQEMQEKLQNFAQLPA-HRVTDSCVVALLSH GVE-------GGIYGVDGK----LLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG---D ET-DRGVDQQ--DGKNH----------TQSPGCEESDAG----KEE-------------- LMKMRLP-----TRSDMIC---GYACLK--G--NAAMRNTKRGSWYIEALTQVFSER--- -A---CDMHVA--DMLVKVNALIKEREGYA--PGTEFHRCKEMSEYCS-----TLCQQLY LFPGYPPT------------- >C_intestinalis_ENSCINP00000007986 ------------------------------------------------------------ --------------------------------------------MLSTHKEK----LRTN RHT-------------LCKELVVD--ELLQELIGEG------------------------ ------------------------------------------------------------ -----------IFNDILADRVLSHQRDFK---KNVEFLTLLPGRGPNAFNAF-------- ------------------------------------------------------------ ---------------------------------------------------RI-ALINSD QSH-LAELLDPAQGV-----SQPNESNANDGSGGPELSASIFRFESIATANSNLPGTSGT SAPLSRRRPMENTDQSSTSIASSQVIYANQGTPPKRNRESSSYIEQMDDAPSPTDSLSNI RSTASVHSLFSRSDVRTQSNTAINHINTVQSPTSTKAATSYQINLHQGMDLFDGPTVSDL TVRKSTHQ----HLMQHTDCYQMTMRGRPKGAALIISVEKFH--PESD-------LLNRE GSEK-DRVRLELVLQQIGFQ-CYVLINGTAEQIVSTLQTFAELEE-HYDNSCSLVAAMSH GDA-------GCFYGSDGV----SVAIDTVVNFFSNQNCHSLQKKPKIFLFQACQG---D EY-DMGVDEV--DGPVQ---------APVGDVDNTSTSS----SND-------------- HIRNKLP-----QKSDMLI---GQATMK--G--FAAMRNTKHGSWYIQAFVRVLARH--- -A---CDTDLL--DMMTKVNNILKHKEGWC--PGSVYHRCKVMPEFKS-----SLSKKLY FFPGI---------------- >M_domestica_ENSMODP00000004412 ------------------------------------------------------------ --------------------------------------------MEESQREL----FQKN RLR-------------LVCELQVE--PLWDLMLDRE------------------------ ------------------------------------------------------------ -----------LFTRDMIEDIQRA--GTR-RDQARQLVTDLQTRGKRALPIF-------- ------------------------------------------------------------ ---------------------------------------------------IS-CLEATG QWD-LAALLSESNTT------------------------------------------LTQ QPDPIDIKPVEMIRSGGLRSTGRYTSMVSLHLLLLANSPFLYFIDAVLVSAHNLFPLELI KRQPTFSKV-----------------------------------------------LSLL YKLRFPFC----PPPQVGQVYT--LNSDPCGYCLIINNVDFC--ASSG-------LSSRK GSNI-DCEKMHNRFQALHFA-VEVERNLSAKGMGAALQQLAER-D-HSALDCCVVVILSH GCQASHIQFPGAIHGTDGA----SISVERIVNIFSGSRCPSLGGKPKLFFIQACGG---D QR-DHGFQVS--SNIPEDKSPGSDPETDATPFQN---NF----DQP-------------- DAVASLP-----TPSDILV---SYSTFP--G--FVSWRDPKSGSWYIETLDRVLEEW--- -A---DREDLL--HMLLMVSNAVSAR-----------GTYKQIPGCFN-----FLRKRFF FKTK----------------- >O_anatinus_ENSOANP00000000517 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AASGEVMVDSKS------------------ ------------------------------------------------------------ ---------------------------------------------------FH-SSQGYS SRK-VPGKQFLG------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSASLDDRYR--MDYPNMGICLIINNKNFH--PDTR-------MGCRS GTDV-DAASLRDTFKKLKYE-VRCKNDLKRREILELLTSVAHE-D-HSKRSSFVCVLLSH GEE-------GVIFGTDG-----SLELKSLASLFRGDNCRSLVGKPKLFIVQACRG---T EL-DSGVEAD--SSS----------------------------ADD-------------- GSEQKIP-----VEADFLY---AYSTAP--G--YYSWRNSMNGSWFIQALCAMLKQH--- -A---HTLELL--HILTRVNRKVATEFESYS-LDATFNAKKQIPCIVS-----MLTKELY FPY------------------ >P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MENTENSVDSKS------------------ ------------------------------------------------------------ -------------------------------------------------------IKNLE PKV-IHGSKSMD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SGISLDNSYK--MDYPEMGLCIIINNKNFH--KSTG-------MASRS GTDV-DAANLRETFRNLKYE-VRNKNDLTREEIVELMRDVAKE-D-HSKRSSFVCVLLSH GEE-------GIIFGTNG-----PVDLRKITNFFRGDRCRSLTGKPKLFIIQACRG---T EL-DCGIETD--SGV----------------------------DDD-------------- MACHKIP-----VEADFLY---AYSTAP--G--YYSWRNSKDGSWFIQSLCAMLKQY--- -A---DKLEFM--HILTRVNRKVATEFESFS-LDATFHAKKQIPCIVS-----MLTKELY FYH------------------ >P_pygmaeus_ENSPPYP00000020323 ------------------------------------------------------------ -------------MAAPTAGSWSTFEHKELMAADRGRRILGVCGMHPHHQET----LKKN RVV-------------LAKQLLLS--ELLEHLLEKD------------------------ ------------------------------------------------------------ -----------IITLEMRELIQAKVGSFS---QNVELLNLLPKRGPQAFDAF-------- ------------------------------------------------------------ ---------------------------------------------------CE-ALRETK QGH-LEDMLLTTLSG---------------LQ--------------HVL--------PPL SCDYDLSLPFPVCESC-----------------PLYKKLRLST-DTVEHSLDNKDGP--- --------------------------------------------------------VCLQ VKPCTPEF----YQTHFQLAYR--LQSRPRGLALVLSNVHFT--GEKE-------LEFRS GGDV-DHSTLVTLFKLLDYD-VHVLCDQTAQEMQEKLQNFAQLPA-HRVTDSCIVALLSH GVE-------GAIYGVDGK----LLQLQEVFQLFDNANCPSLQNKPKMFFIQACRG---D ET-DRGVDQQ--DGKNH----------AGSPGCEESDAG----KEK-------------- LPKMRLP-----TRSDMIC---GYACLK--G--TAAMRNTKRGSWYIEALAQVFSER--- -A---CDMHVA--DMLVKVNALIKDREGYA--PGTEFHRCKEMSEYCS-----TLCRHLY LFPGHPPT------------- >P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MENTENSVDSKS------------------ ------------------------------------------------------------ -------------------------------------------------------IKNLE PKI-IHGSQSMD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SGISLDNSYK--MDYPEMGLCIIINNKNFH--KSTG-------MTSRS GTDV-DAANLRETFRNLKYE-VRNKNDLTREEIVELMRDVSKE-D-HSKRSSFVCVLLSH GEE-------GIIFGTNG-----PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRG---T EL-DCGIETD--SGV----------------------------DDD-------------- MACHKIP-----VEADFLY---AYSTAP--G--YYSWRNSKDGSWFIQSLCAMLKQY--- -A---DKLEFM--HILTRVNRKVATEFESFS-FDATFHAKKQIPCIVS-----MLTKELY FYH------------------ >H_sapiens_ENSP00000311032 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MENTENSVDSKS------------------ ------------------------------------------------------------ -------------------------------------------------------IKNLE PKI-IHGSESMD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SGISLDNSYK--MDYPEMGLCIIINNKNFH--KSTG-------MTSRS GTDV-DAANLRETFRNLKYE-VRNKNDLTREEIVELMRDVSKE-D-HSKRSSFVCVLLSH GEE-------GIIFGTNG-----PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRG---T EL-DCGIETD--SGV----------------------------DDD-------------- MACHKIP-----VEADFLY---AYSTAP--G--YYSWRNSKDGSWFIQSLCAMLKQY--- -A---DKLEFM--HILTRVNRKVATEFESFS-FDATFHAKKQIPCIVS-----MLTKELY FYH------------------ >M_domestica_ENSMODP00000005560 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MEDTGTTVDAKS------------------ ------------------------------------------------------------ -------------------------------------------------------IKNSG VKS-LHSSKSVE------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SGLS-SDSYK--MDYPEMGLCVIINNTHFH--NDTE-------LSPRT GSDK-DAANLIDIFRSLKYE-VRNKNNLTRDKMIELLRQVSEE-D-HSQRSSFVCVILSH GEE-------GVIFGTDD-----SVELKELTYFFKGYKCKSLTGKPKLFIIQACQG---R EF-DCGVETD--SGT----------------------------DED-------------- VACHKIP-----VEADFLY---AYSTVP--G--YYSLRDPKDGSWFIQALCAVLKQH--- -A---HKLEIM--QILTRVNRKVATEFESYS-SKASLHAKKQMPCIMS-----MLTKELY FSH------------------ >E_caballus_ENSECAP00000003321 ------------------------------------------------------------ -------------MAAPSAPSLPALQQKGLMAADRGRRILGVCGMHPDHQEA----LKKN RVV-------------LAKQLLLS--ELLEHLLEKD------------------------ ------------------------------------------------------------ -----------IITLEMRELIQAKVTSFG---QNVELLNLLPKRGPQAFEAF-------- ------------------------------------------------------------ ---------------------------------------------------CV-ALRETK QGH-LEDLLLTTLSG---------------LQ--------------HVL--------PPL SCDYDLSLPFPVCESC-----------------PPHKQLRLST-DTVEHSLDNGDGP--- --------------------------------------------------------PCLQ VKPCTPEF----YQAHYQLAYR--LQSRPRGLALVLSNVHFT--GEKD-------LEFRS GGDV-DHSTLVTLFKLLGYN-VHVLLDQTAKEMQEKLQNFAQLPA-HRVTDSCIVALLSH GVE-------GGIYGVDGK----LLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG---D ET-DRGVDQQ--DGKNH----------AKSPECEESDAG----KEE-------------- LLKMRLP-----TRSDMIC---GYACLK--G--TAAMRNTKRGSWYIEALTQVFSER--- -A---CDMHVA--DMLVKVNALIKEREGYA--PGTEFHRCKEMSEYCS-----TLCRHLY LFPGHPPT------------- >E_caballus_ENSECAP00000019797 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MENSKISVDSKS------------------ ------------------------------------------------------------ -------------------------------------------------------IKNSE TKI-LHGSKSMD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SGISLDSSYK--MDYPEMGLCIIINNKNFH--KSTG-------MASRS GTDV-DAANLRETFTNLKYE-VRNKNDLTGEEIVALMRSVSKE-D-HSKRSSFICVLLSH GEE-------GIIFGTNG-----PIDLKKLTCFFKGDCCRSLAGKPKLFIIQACRG---T EL-DSGIETD--SGI----------------------------EDD-------------- MACQKIP-----VEADFLY---AYSTAP--G--YYSWRNSKDGSWFIQSLCAMLKLY--- -A---HKLELM--HILTRVNRKVAMEFESYC-LDPTFHGKKQIPCIVS-----MLTKELY FYH------------------ >M_musculus_ENSMUSP00000026062 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MTDDQDCAAELEKVDSSSEDGVDAKPDRSSIISSI--------- ------------------------------------------------------------ ---------------------------------------------------LL-KKKRNA SAG-PVRTG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RDRVPTYLYR--MDFQKMGKCIIINNKNFD--KATG-------MDVRN GTDK-DAGALFKCFQNLGFE-VTVHNDCSCAKMQDLLRKASEE-D-HSNSACFACVLLSH GEE-------DLIYGKDG-----VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG---T EL-DDGIQAD--SGPIN-D------------------------IDA-------------- NPRNKIP-----VEADFLF---AYSTVP--G--YYSWRNPGKGSWFVQALCSILNEH--- -G---KDLEIM--QILTRVNDRVARHFESQS-DDPRFNEKKQIPCMVS-----MLTKELY FSR------------------ >T_guttata_ENSTGUP00000011206 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------KKKNG EEE-QPKPSLSNQY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RIVTPTFQYN--MDYKKVGKCIIINNKNFE--DKTG-------MGTRN GTDK-DAGDLAKSFKNLGFE-VDIHHDRSRDDMEKLLKKAAEE-N-HSDAACFACILLSH GEE-------GLIYGTDG-----PMAIKSLTALFRGDKCKSLIGKPKLFFIQACRG---S EF-DEGIQTD--SGPAN-DTLE---------------------TDA-------------- NPRYKIP-----VEADFLF---AYSTVP--G--YYSWRNPGRGSWFVQSLCSVLNEH--- -G---KQLEIM--QILTRVNYVVATNFESQS-DDPRFSEKKQIPCVVS-----MLTKELY F-------------------- >X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------S-TKKKKT EDP-EKPPQASDNV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RIVTPAFQYK--MNYGKVGRCIIINNKNFD--DITG-------MSPRN GTDI-DARDLLRCFKGLGFD-VTVFNNKSCTEMETLLRSVAEQ-D-HKDSACFACIFLSH GEE-------GLIYGTDG-----AMPIKVLTTLFRGDKCRSLVGKPKLFFIQACRG---C EF-DDGLETD--AGPSN-DSLE---------------------TDA-------------- NPRHKIP-----VEADFLY---AYSTVP--G--YYSWRNPGRGSWFVQALCNVLNEH--- -G---KELEVM--QILTRVNYLVATQFESYC-DDPQFNKKKQIPCVVS-----MLTKELY FKPC----------------- >H_sapiens_ENSP00000358327 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MDCVGWPPGRKWHLEKN TSCGGSSGICASYVTQMADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSL--------- ------------------------------------------------------------ ---------------------------------------------------FS-KKKKNV TMR-SIKTT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RDRVPTYQYN--MNFEKLGKCIIINNKNFD--KVTG-------MGVRN GTDK-DAEALFKCFRSLGFD-VIVYNDCSCAKMQDLLKKASEE-D-HTNAACFACILLSH GEE-------NVIYGKDG-----VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG---T EL-DDGIQAD--SGPIN-D------------------------TDA-------------- NPRYKIP-----VEADFLF---AYSTVP--G--YYSWRSPGRGSWFVQALCSILEEH--- -G---KDLEIM--QILTRVNDRVARHFESQS-DDPHFHEKKQIPCVVS-----MLTKELY FSQ------------------ >P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MDCVGWPPGRKWHLEKN TSCGGSSGICASYVTQMADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSL--------- ------------------------------------------------------------ ---------------------------------------------------FS-KKKKNV TMR-SIKTT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RDRVPTYQYN--MNFEKLGKCIIINNKNFD--KVTG-------MGVRN GTDK-DAEALFKCFRSLGFD-VIVYNDCSCAKMQDLLKKASEE-D-HTNAACFACILLSH GEE-------NVIYGKDG-----VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG---T EL-DDGIQAD--SGPIN-D------------------------TDA-------------- NPRYKIP-----VEADFLF---AYSTVP--G--YYSWRSPGRGSWFVQALCSILEEH--- -G---KDLEIM--QILTRVNDRVARHFESQS-DDPRFHEKKQIPCVVS-----MLTKELY FSQ------------------ >T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MAGEAAGIPELGGEAEGEHRCEDDVDAKPDRRGRFLLF--------- ------------------------------------------------------------ ---------------------------------------------------KS-KKKNDG QMR-EQDYCSESHY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RIVSPTFQYR--MSHQRVGKCIIINNKNFD--EKTG-------MNVRN GTDR-DAGELYKCFKSLGFD-VFIYNDQTCEKMEHLLREASEE-D-HSDSSCFACILLSH GEE-------GMIYGTDG-----AMPIKTMTSMFRGDMCKSLVGKPKLFFIQACRG---S EF-DDGIQTD--SGPPN-DTME---------------------TDA-------------- NPRHKIP-----VEADFLF---AYSTVP--G--YYSWRNPGRGSWFVQALCNVLNEF--- -G---KQLEIM--QILTRVNYMVATSFESWS-EDPRFSEKKQIPCVVS-----MLTKELY FKPC----------------- >O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MADDQAHAGELGAGDSESADAVDAKPDRSSFVPAL--------- ------------------------------------------------------------ ---------------------------------------------------FS-KKKKNG PKQ-SAKAT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RDQVPSYQYN--MNFDKMGKCIIINNKNFD--KVTG-------MGVRN GTDK-DAEALFKCFRSLGFD-VMVYNDCSCARMQDLLKRASEE-D-HTNSACFACILLSH GEE-------NLIYGKDG-----VIPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG---T EL-DDGIQAD--SGPIN-D------------------------TDA-------------- NPRHKIP-----VEADFLF---AYSTVP--G--YYSWKNPGRGSWFVQALCSILDEH--- -G---KELEVM--QILTRVNDRVARHFESQS-DDPRFNEKKQIPCVVS-----MLTKELY FCR------------------ >M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------S-KKKKNV SGQ-SIKTT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RDRVPTYQYN--MNFEKMGKCIIINNKNFD--KVTG-------MGVRN GTDK-DAEALFKCFQSLGFD-VIVHNDCSCAKMKDLLKKASEE-D-HTNAACFACILLSH GEE-------NLIYGKDG-----VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG---T EL-DDGIQAD--SGPIN-D------------------------TDA-------------- NPRYKIP-----VEADFLF---AYSTVP--G--YYSWRSPGRGSWFVQALCSILEEH--- -G---KDLEIM--QILTRVNDRVARHFESQS-DDPCFHEKKQIPCVVS-----MLTKELY FSH------------------ >E_caballus_ENSECAP00000013731 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MADDQDCVVEQGAGDSTSTDAVDAKPDRSSFVPSL--------- ------------------------------------------------------------ ---------------------------------------------------FS-KKKKNG PER-SITTN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RNREPTYQYN--MNFEKVGKCVIINNKNFD--RGTG-------MGVRN GTDK-DAEALFKCFRNLGFD-VVVYNDCSCAKMKSLLKQASEE-D-HRNSACFACILLSH GEE-------NLIYGTDG-----MTPIKDLTGHFRGDRCKTLLEKPKLFFIQACRG---T EL-DDGIQAD--SGPINDD------------------------TDA-------------- NPRYKVP-----VEADFLF---AYSTVP--G--YYSWRNPGSGSWFVQALCSILNEH--- -G---KSLEII--QILTRVNHRVARHFESHS-DDPRFHQKKQIPCVVS-----MLTKELY F-------------------- >B_taurus_ENSBTAP00000024166 ------------------------------------------------------------ -------------MAAPSAGFQYPLQPKEQMAADRGRRMLRGCGMHPDHQEA----LKKN RVV-------------LAKELLLS--ELLEHLLEKD------------------------ ------------------------------------------------------------ -----------IITLEMREHIQAKTGSFG---QNVELLNLLPKRGPQAFDAF-------- ------------------------------------------------------------ ---------------------------------------------------CV-ALRETK QSH-LEELLLRTLSG---------------LQ--------------PVV--------PPL SCDYDLSLPFPVCESC-----------------TRHKRLHLSP-DAVEHSLDHGDGP--- --------------------------------------------------------PCLQ VKPCTPEF----YQTHHHLAYR--LQSRPRGLALVLSNVHFT--GEKD-------LEFRS GGDV-DHSTLVTLFKLLGYK-VHVLLDQTAQEMQEKLQNFAQLPV-HRVTDSCIVALLSH GVE-------GGVYGVDGK----LLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG---D ET-DRGVDLQ--DGKNH----------DRSPKCEESDAS----REE-------------- LLKMRLP-----TRSDMIC---GYACLR--G--TAAMRNTKRGSWYVEALTQVFSER--- -A---CDMHVA--DMLVKVNALIKEREGYA--PGTEFHRCKEMSEYCS-----TLCRHLY LFPGHPPT------------- >P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MDCVGWPPGRRWHLEKN TSCSGSSGICASYVTQMADDQGCVEEQGLGDSANEDSVDAKPDRSSFVPFL--------- ------------------------------------------------------------ ---------------------------------------------------FS-MKKKNV SMQ-SIKTT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RDRVPTYQYN--MNFEKLGKCIIINNKNFD--KVTG-------MGVRN GTDK-DAEALFKCFRSLGFD-VIVYNDCSCAKMQDLLKKASEE-D-HTNAACFACILLSH GEE-------NLIYGKDG-----VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG---T EL-DDGIQAD--SGPIN-D------------------------TDA-------------- NPRYKIP-----VEADFLF---AYSTVP--G--YYSWRSPGRGSWFVQALCSILEEH--- -G---KDLEIM--QILTRVNDRVARHFESQS-DDPRFHEKKQIPCVVS-----MLTKELY FSQ------------------ >G_gallus_ENSGALP00000029853 ------------------------------------------------------------ ----------------------------------------GACGMQRYHQEA----LKKN RVM-------------LARELVLK--ELMEHMIEKD------------------------ ------------------------------------------------------------ -----------IITIEMVEMIQAKSGSFS---QNVEFLNLLPKRGPNAFSAF-------- ------------------------------------------------------------ ---------------------------------------------------CE-ALQETK QQH-LAEMILKTESS---------------LR--------------HGI--------ATL EQRYGSNLPLPLSESCNSK--------------RPRLIVFFCT-KPVEHSLDSGDGP--- --------------------------------------------------------PIPP VKHCTPEF----YRDHQHLAYK--LISEPRGLALILSNIHFS--SEKD-------LEYRS GGDV-DCASLELLFKHLGYQ-VTVFHDQSAEEMESALERFSKLPD-HQDVDSCIVALLSH GVE-------GGVYGTDGK----LLQLQEAFRLFDNANCPNLQNKPKMFFIQACRG---D ET-DRGVDQR--DGKEW----------SDSPGCEESDAN----KEE-------------- NLKLRLP-----TRSDMIC---GYACLK--G--TAAMRNTKRGSWYIEALTTVFAED--- -S---RDTHVA--DMLVKVNRQIKQREGYA--PGTEFHRCKEMSEYCS-----TLCRDLY LFPGYVPGK------------ >M_domestica_ENSMODP00000001598 ------------------------------------------------------------ -------------------------------------RMLGVWGMEQEHQEA----LKKN RVV-------------LAKQLLLS--ELLEHLLEKD------------------------ ------------------------------------------------------------ -----------IITLEMRELIQAKVGSFS---QNVEFLNLLPKRGPHAFEAF-------- ------------------------------------------------------------ ---------------------------------------------------CD-ALRETK QGH-LEDLLHRTLYS---------------FQ--------------NLR--------PPL GCDYDSSFPLPVCDSC-----------------PPHKQLRLSV-ETMEHSLDNGDGP--- --------------------------------------------------------PSLQ VKPCTPEF----YQTHQHLAYR--LQSRPRGLAMVLSNVHFN--GEKD-------LEFRS GGDV-DHSSLVTLFKLLDYD-VHVLRDQTAQKMQENLQRFAQLSA-HQSTDSCMVALLSH GIE-------GGIYGVDGK----LLQLQEVFRLFDNANCPNLQNKPKMFFIQACRG---D ET-DRGVDLR--DGKEH----------VASPGCEESDAG----KEK-------------- ILKMRLP-----TRSDMIC---GYACLK--G--TAAMRNTKRGSWYIEALTQVFSER--- -A---RDMHVA--DML--VNALIKDREGYA--PGTEFHRSKEMSEYSS-----TLCRHLY LFPGHPPT------------- >T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------SMQMAGEPTEISDLGGEVEEGGQSEDDVDAKPDRKGRFLLF--------- ------------------------------------------------------------ ---------------------------------------------------KS-KKNKDG QMR-EQDYCSESHY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RIVSPTFQYK--MSHQRVGKCIIINNKNFD--EKTG-------MNVRN GTDR-DAGELFKCFKTLGFD-VFIYNDQTCEKMERLLREASEE-D-HSDSSCFACILLSH GEE-------GMIYGTDG-----AMPIKTMTSMFRGDMCKSLVGKPKLFFIQACRG---S EF-DDGIQTD--SGPPN-DTME---------------------TDA-------------- NPRHKIP-----VEADFLF---AYSTVP--G--YYSWRNPGRGSWFVQALCNVLSEF--- -G---KQLEIM--QILTRVNYMVATSFESWS-EDPRFSEKKQIPCVVS-----MLTKELY FKQC----------------- >C_familiaris_ENSCAFP00000005409 ------------------------------------------------------------ -------------MAAASAGRPAALQRKAPTAAGRGRRILGVCGMHPDHQEA----LKKN RVV-------------LAKQLLLS--ELLEHLLEKD------------------------ ------------------------------------------------------------ -----------IITLEMREHIQAKVGGFS---QNVELLNLLPKRGPQAFDAF-------- ------------------------------------------------------------ ---------------------------------------------------CV-ALRETK QGH-LEDLLLTTLSG---------------LQ--------------HGL--------PPL SCDYDLSLTFPMCESC-----------------PPQKQLRLSP-DTVEHSLDNGDGP--- --------------------------------------------------------PCLQ VKPCTPEF----YQTHYQLAYR--LQSRPRGLALVLSNVHFT--GEKD-------LEFRS GGDV-DHSTLVTLFKLLGYK-VHVLLDQTAQEMKEKLQNFAQLPA-HRVTDSCIVALLSH GVE-------GGIYGVDGK----LLQLQEVFRLFDNASCPNLQNKPKMFFIQACRG---D ET-DRGVDQQ--DGKNH----------TGSSECEESDAS----KEE-------------- LLKTRLP-----TRSDMIC---GYACLR--G--TAAMRNTKRGSWYIEALTQVFSER--- -A---CDTHVA--DMLVKVNALIKEREGYA--PGTEFHRCKEMSEYCS-----TLCRHLY LFPGHPPT------------- >E_caballus_ENSECAP00000013268 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -GE-EQNMTEIDAFY--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----K-R----EMFDPAEKYK--MDHKRRGIALIFNHERFF--WHLT-------LPDRR GTSA-DRDNLMRRFSDLGFE-VKCFNDLKAEELLLKIYEVSTS-S-HADADCFVCVFLSH GEG-------NHIYAYDA-----KIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRG---D QH-DVPVTPL--DVVDH-----------GTDKLDANVTQ----VDA-------------- ASVYTLP-----AGADFLM---CYSVAE--G--YYSHRETINGSWYIQDLCEMLARF--- -G---SSLEFT--ELLTLVNRKVSQRRVDFC-KDPSAIGKKQVPCFAS-----MLTKKLH FFPKSK--------------- >D_rerio_ENSDARP00000019984 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MDKEALTSENEVSGDDQENYGKGDVT DAKPDPKAMCRVDKE-ALTSEIEVLEEDQDSYGEEDVTDAKPDRKGRFRLF--------- ------------------------------------------------------------ ---------------------------------------------------GN-FKKNDG KLQ-EKG-ESESHY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RIVSPTFQYK--MSHQRVGKCIIINNKNFD--EKTG-------MNVRN GTDR-DAGELFKCFKSLGFD-VAVYNDQTCRNMERLLKAVSEE-D-HSDSSCFACILLSH GEE-------GMIYGTDG-----AMPIKTMTSLFKGDVCKSLVGKPKLFFIQACRG---S EF-DDGVQTD--SGPPN-DTIE---------------------TDA-------------- NPRHKIP-----VEADFLF---AYSTVP--G--YYSWRNPGRGSWFVQALCNVLSEF--- -G---KQLEIM--QILTRVNYMVATSFESWS-EDPRFSEKKQIPCVVS-----MLTKELY FN------------------- >A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------PTFRYR--MDYKKLGKCVIINNKNFA--KDTG-------MRIRN GTDK-DAGDLQKCFRGIGFD-VSIYNDLTCDNMEKILGEAALE-N-HDDAACFACILLSH GEE-------GLIYGTDG-----CMAIKNLTGLFRGDKCQSLIGKPKLFFIQACRG---S EF-DAGIQTD--SGSSN-DNLE---------------------MDA-------------- NPRYKIP-----VEADFLY---AYSTVP--G--YFSWRNPGKGSWFVQSLCSVLNDH--- -G---KELEVL--QILTMVNYKVARNYESQS-DDPRFSQKKQVPCVVS-----MLTKELY F-------------------- >M_musculus_ENSMUSP00000030747 ------------------------------------------------------------ --------------------------------------------MDEADRQL----LRRC RVR-------------LVSELQVA--ELWDALLSRE------------------------ ------------------------------------------------------------ -----------LFTRDMIEDIQQAGSGSR-RDQARQLVTDLETRGRQALPLF-------- ------------------------------------------------------------ ---------------------------------------------------IS-CLEDTG QGT-LASLLQSGRQA------------------------------------------AKQ DPE--AVKPLDHLVPVVLGPMGLTAKEQR-VVKLDPSQPAVGNLTPVVLGPEELWPARLK PEVLR-PETPRPVDIG----------------------------------------SGGA HDVCVPGK----IRGHADMAYT--LDSDPCGHCLIINNVNFC--PSSG-------LGTRT GSNL-DRDKLEHRFRWLRFM-VEVKNDLTAKKMVTALMEMAHR-N-HRALDCFVVVILSH GCQASHLQFPGAVYGTDGC----SVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGG---E QK-DHGFEVA--CTSSQGRTLDSDSEPDAVPYQEGPRPL----DQL-------------- DAVSSLP-----TPSDILV---SYSTFP--G--FVSWRDKKSGSWYIETLDGILEQW--- -A---RSEDLQ--SLLLRVANAVSAK-----------GTYKQIPGCFN-----FLRKKLF FKTS----------------- >X_tropicalis_ENSXETP00000015203 ------------------------------------------------------------ ----------------------------------------MLGGMQKHHKDA----LQRL RVT-------------LLHDMIIE--ELVEHLVSSG------------------------ ------------------------------------------------------------ -----------ILTPIMHSTIMAHRSEYK---QNVTLLTQLPKRGPRAFSEF-------- ------------------------------------------------------------ ---------------------------------------------------CN-ALHATG QRH-LAEQLEEEAQQ--------------------------------------QQMESVT PEVHERSFPLPVQEST-----------------PSRPRRQFCR-EYNEESIDDGDGP--- ----------------------------------------------------------GT VQLCSVDF----YLSHHQQAYK--MHSCPRGRALIISNVAFE---TQD-------LDHRY GGEV-DVTSLEKLFSSLGFQ-VEVRRNLNAQNMMSQLGAFSALPA-HSALDSCVVAVLSH GLD-------GAVYGTDGK----LVQLQDVFTAMDNAHCPQLQNKPKMFFIQACRG---E EA-DRGVDQR--DGREQ----------SASPGCEQSDAG----RE--------------- DIKVRLP-----TQSDMIC---AYACLK--G--TVSLRNTKRGSWFVQDLVSVFSQY--- -S---KNTHVA--DMLVKVNALIKEREGHA--PGTEFHRCKEMSEYCS-----TLCRDLY LFPG----------------- >M_domestica_ENSMODP00000005556 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MEDTGTTVDAKS------------------ ------------------------------------------------------------ -------------------------------------------------------TKNSG VKL-FHGSKSVE------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SGLS-SDSYK--MDYPEMGLCIIINNKNFH--PNTG-------MSFRS GTDV-DAASLSDTFRSLKYE-VRIKNDLTCNEITELLNSVSKE-D-HSQRSSFICVILSH GEE-------GVIFGTDR-----SVELKRLTCFFRGDKCRSLTGKPKLFIIQACRG---T EL-DCGVETD--SGT----------------------------DED-------------- IACQKIP-----VEADFLY---AYSTAP--G--YYSWRNSKDGSWFIQALCAVLKQH--- -A---HKLEIM--QILTRVNRKVATEFESYS-LDISFHAKKQVPCIMS-----MLTKELY FSH------------------ >O_latipes_ENSORLP00000010793 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MDMAETAEELSGKDQVDTKP------------------ ------------------------------------------------------------ ------------------------------------------------------VISKRS PAN-QPNPRSTDVCVI-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------KQDADPYRYS--MDYPKMGICLIINNKNFH--KDSG-------MGPRN GTDN-DAAAAWKSFMKLGYE-IQMYNDQTVDQMKKLFRQMSNQ-D-HSKFASFACVILSH GEE-------GVIYGTDG-----PVSFNKLIECLKGRSCLSLVGKPKLFFIQACRG---T LF-DEGIEHD--A-------------------------------KD-------------- DTSEKIP-----LEADFLF---AYSTVS--G--YYSWRSTANGSWFIQSLCEMLEKF--- -S---KTLDLM--QIMTRVNHKVATHFESSS-NAPGFSGKKQIPCIVS-----MLTKDFY FPYESN--------------- >C_intestinalis_ENSCINP00000002956 ------------------------------------------------------------ -------------------------------------------AMKKRHRNT----LIKN RVK-------------LAKCLHLD--EVLQYLVQCG------------------------ ------------------------------------------------------------ -----------ILTDVTVERITSKPTRFS---QNVAFLTCLPTRGPRAYGTF-------- ------------------------------------------------------------ ---------------------------------------------------LE-ALRISS QEH-LVDILEKVDIS-----------------------------------NAIPNNKPIT PTTLHATITSNVHSE------------------FVCARRQPMEIGKCEDKNDAKDGH--- --------------------------------------------------------NRLR VQNSTVAF----FNETYNSGYK--MTTKSRGYALIVCIGRFN--AGVR-------LPDRQ GTDA-DKKNLLAIFEQINYK-TILVENCNKFEMERRVKQFAQMEE-HRKCDSCAVAILSH GSK-------TDIYASDGR----SIPIESLIKMFDNVNCPPLRNKPKIFFIQCCRG---N NM-DQGIDAT--DGP---------------PTLNSETSD----SYN-------------- STTHNIT-----TDVDIIS-----TASK--R--NAALRNTRHGSWYIQVLVKTIAQH--- -A---HEMDLL--EILTLVNSAIKSKEGHS--TDFDSQGVKEMSEFHS-----TLCKKLF FYPGIVQTE------------ >P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MSS--ASGLRRGH----------------------------------- ------------------------------------------------------------ -----------------------------------------------------------P AGG-EENMTETDAFY--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----K-R----EMFDPAEKYK--MDHRRRGIALIFNHERFF--WHLT-------LPERR GTCA-DRDNLTRRFSDLGFE-VKCFNDLKAEELLLKIHEASTV-S-HADADCFVCVFLSH GEG-------NHIYAYDA-----KIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRG---N QH-DVPVIPL--DVVDN-----------QTEKLDTNITE----VDA-------------- ASVYTLP-----AGADFLM---CYSVAE--G--YYSHRETVNGSWYIQDLCEMLGKY--- -G---SSLEFT--ELLTLVNRKVSQRRVDFC-KDPSAIGKKQVPCFAS-----MLTKKLH FFPKSN--------------- >B_taurus_ENSBTAP00000016642 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MSS--EPPPRRAR----------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G PGE-EQNMTEIDAFP--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----R-R----EIFDPTEKYK--MDHKRRGIALIFNHERFF--WHLT-------LPNRP GTSA-DRDNLRRRFSDLGFE-VKCFDDLRAEELLLKIHEASTA-S-HVDADCFLCVFLSH GEG-------NHIYAYDA-----KIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRG---S QH-DVPVIPL--DVVDH-----------RTDTPDANLTQ----VDA-------------- ASVYTLP-----AGADFLM---CYSVAE--G--YYSHRETVNGSWYIQDLCEMLGKF--- -G---SSLEFT--ELLTLVNRKVSQRRVDFC-RDPNAIGKKQVPCFAS-----MLTKKLH FSPKSK--------------- >R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MDNNETSVDSKS------------------ ------------------------------------------------------------ -------------------------------------------------------INNFE TKT-IHGSKSMD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SGIYLDSSYK--MDYPEMGLCIIINNKNFH--KSTG-------MSARN GTDV-DAANLRETFMALKYE-VRNKNDLTREEIMELMDSVSKE-D-HSKRSSFVCVILSH GDE-------GVIFGTNG-----PVDLKKLTSFFRGDYCRSLTGKPKLFIIQACRG---T EL-DCGIETD--SGT----------------------------DDD-------------- MACQKIP-----VEADFLY---AYSTAP--G--YYSWRNSRDGSWFIQSLCAMLKLY--- -A---HKLEFM--HILTRVNRKVATEFESFS-LDATFHAKKQIPCIVS-----MLTKELY FYH------------------ >H_sapiens_ENSP00000265164 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MSS--ASGLRRGH----------------------------------- ------------------------------------------------------------ -----------------------------------------------------------P AGG-EENMTETDAFY--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----K-R----EMFDPAEKYK--MDHRRRGIALIFNHERFF--WHLT-------LPERR GTCA-DRDNLTRRFSDLGFE-VKCFNDLKAEELLLKIHEVSTV-S-HADADCFVCVFLSH GEG-------NHIYAYDA-----KIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRG---N QH-DVPVIPL--DVVDN-----------QTEKLDTNITE----VDA-------------- ASVYTLP-----AGADFLM---CYSVAE--G--YYSHRETVNGSWYIQDLCEMLGKY--- -G---SSLEFT--ELLTLVNRKVSQRRVDFC-KDPSAIGKKQVPCFAS-----MLTKKLH FFPKSN--------------- >G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------QVNGA-RLTSAQDVA--AEEGGPTGDQTDAKPDRRGRFLLF--------- ------------------------------------------------------------ ---------------------------------------------------GNIKKNKDG QTR-EQDYSSESHY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RVVSPTFQYK--MSHQRVGKCIIINNKNFD--EKTG-------MNVRN GTDR-DAGELFKCFKSLGFD-VFIYNDQTCGKMESLLREASEE-D-HSDSSCFACILLSH GEE-------GMIYGTDA-----AMPIKSMTSLFRGDMCKSLVGKPKLFFIQACRG---S EF-DDGIQTD--SGPPN-DTLE---------------------TDA-------------- NPRHKIP-----VEADFLF---AYSTVP--G--YYSWRNPGRGSWFVQALCNVLNEF--- -G---KQLEIM--QILTRVNYMVATSFESWS-EDPRFSEKKQIPCVVS-----MLTKELY FN------------------- >P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MSS--VSGLRRGH----------------------------------- ------------------------------------------------------------ -----------------------------------------------------------P AGG-EENMTETDAFY--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----K-R----EMFDPAEKYK--MDHRRRGIALIFNHERFF--WHLT-------LPERR GTCA-DRDNLTRRFSDLGFE-VKCFNDLKAEELLLKIHEVSTV-S-HADADCFVCVFLSH GEG-------NHIYAYDA-----KIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRG---N QH-DVPVIPL--DVVDN-----------QTDKLDTNITE----VDA-------------- ASVYTLP-----AGADFLM---CYSVAE--G--YYSHRETVNGSWYIQDLCEMLGKY--- -G---SSLEFT--ELLTLVNRKVSQRRVDFC-KDPSAIGKKQVPCFAS-----MLTKKLH FFPKSN--------------- >G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MDKLYRDV----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------QSGEDKYRYK--MDYPCMGTCVIINIKNFD--LKTG-------LETRN GTDV-DAAELEKTFSKLGYK-VTLVHDQTADQIVDLLRDVSTQ-D-HSNSGSFVCVLLSR GDE-------GGIYGTDGS----FVNLDELTKFVDGNGCRSLVGKPKLLFIQAARG---N KL-DDGTLSE--GDS----------------------------MDG-------------- QTPSRIP-----VEADFLY---AYSTTP--G--FNAWRDTQNGSWFMQSLCEMLRRF--- -S---GQLELM--QIMTRVNNKVALEYKTT----PGRSGKRQMPCIVS-----LLTKEFY FP------------------- >B_taurus_ENSBTAP00000008706 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------S-KKKKND SGK-SVNIP--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------RDRVPTYQYN--MNFEKVGKCIIINNKNFD--RITG-------MGVRN GTDK-DAEALFKCFRSLGFD-VSVYNDCSCAKMQDLLKKASEE-D-HRNSACFACILLSH GEE-------NLIYGTDG-----KTAIKDLTAHFRGDRCKTLLEKPKLFFIQACRG---T EL-DDGIQAD--SGPIN-D------------------------TDA-------------- NPRYKIP-----VEADFLF---AYSTVP--G--YYSWRNPGSGSWFVQALCSILNEH--- -G---KSLEIL--QILTRVNDRVARHFESQS-DDPRFHEKKQIPCVVS-----MLTKELY F-------------------- >A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------FR--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----R-N----HLFDPAAEYK--MSHKRRGLALIFNHEHFF--WHLM-------LPERR GTQA-DKENLKRGLTDLGFE-VKCFDDLKAEEVLQNIYNVSTD-E-HDDADCFLCVFLSH GED-------DHVYAYDA-----KIEIKSLTNMFKGDKCPSLVGKPKIFVIQACRG---D KH-DDPVIAR--DTVDS------------KKELDINETE----VDT-------------- AAVYTLP-----AGADFLM---CYSVAE--G--YYSHRETINGSWYIQDLCEMLKRH--- -G---SSLEFT--DLLTLVNRKVSHREVDVC-KDRKALGKKQIPCFAS-----MLTKKLY FRPKFK--------------- >O_latipes_ENSORLP00000010095 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MASNRPGEDSTDARKD----------------- ------------------------------------------------------------ ------------------------------------------------------NGELAA GASPAPDRMDVDG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------KPSSHSFRYS--LNFPTIGLCIIINNKNFD--RGTG-------MNQRN GTDI-DAASAMKVFSKLGYR-VKIYNDQTVKQIKQLLTDVSRM-D-HSDSASFVCILLSH GDE-------GVFFGTDG-----SIELKTLTSLFRGDHCKSLVGKPKLFFIQACRG---T EL-DDGIEAD--S--------------------------------K-------------- EDTTKIP-----VEADFLY---AFSTAP--G--YYSWRNTMTGSWFINSLCEMLSKY--- -G---KELELL--HIMTRVNHMVAVEFESIS-TLPGFHAKKQIPCIVS-----MLTKEMY FYP------------------ >M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MENTENSVDSKS------------------ ------------------------------------------------------------ -------------------------------------------------------IKSLE PKI-IHGSKSVD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SGISLENSYK--MDYPEMGLCIIINNKNFH--KSTG-------MASRS GTDV-DAANLRETFINLKYE-VRNKNDLTREEIVELMRNVSKE-D-HSKRSSFVCVLLSH GEE-------GIIFGTNG-----PLDLKKITSFFRGDCCRSLTGKPKLFIIQACRG---T EL-DCGIETD--SGV----------------------------EDD-------------- MACHKIP-----VEADFLY---AYSTAP--G--YYSWRNSKDGSWFIQSLCAMLKQY--- -A---DKLEFM--HILTRVNRKVATEFESFS-LDATFHAKKQIPCIVS-----MLTKELY FYH------------------ >A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----IPVSKSVD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SVIEADESYR--MDHPEMGLCILVNNKNFH--PATG-------MSYRS GTDR-DAAHVVDTFRTLGYM-VKPYNDLTCKQIVDVLHNVSKD-D-HHKRNSFVCVLLSH GED-------GLIYGTDG-----HVELKMLTSFFRGDKCKSLAGKPKLFFIQACRG---T EL-DSGIETD--SAS-----------------------------DE-------------- SMCQKIP-----VEADYLY---AYSTAP--G--YYSWRNSSDGSWFIQSLCSMLKQY--- -S---HKLELM--QILTRVNRKVT-EFTSCS-NHPDFHGKKQIPCIMS-----MLTKDFY FPH------------------ >M_musculus_ENSMUSP00000091238 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MENNKTSVDSKS------------------ ------------------------------------------------------------ -------------------------------------------------------INNFE VKT-IHGSKSVD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SGIYLDSSYK--MDYPEMGICIIINNKNFH--KSTG-------MSSRS GTDV-DAANLRETFMGLKYQ-VRNKNDLTREDILELMDSVSKE-D-HSKRSSFVCVILSH GDE-------GVIYGTNG-----PVELKKLTSFFRGDYCRSLTGKPKLFIIQACRG---T EL-DCGIETD--SGT----------------------------DEE-------------- MACQKIP-----VEADFLY---AYSTAP--G--YYSWRNSKDGSWFIQSLCSMLKLY--- -A---HKLEFM--HILTRVNRKVATEFESFS-LDSTFHAKKQIPCIVS-----MLTKELY FYH------------------ >P_troglodytes_ENSPTRP00000021879 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRM----LEES NLS-------------FLKELLFR--INRLDLLITYLNTRKEEMERELQTPGRAQ---IS AY--------------------------------R------------------------- -----------VMLYQISEEVSRSELRSF-KFLLQEEISKCKLDDDMNLLDI-------- ------------------------------------------------------------ ---------------------------------------------------FI-EMEKRV ILG-EGKLDILKRVC------------------------------------------AQI NRSLLKIINDYEEFSKERSSSLEGSPDEFSNG-------EELCGV--------------- --------------------------------------------------------MTIS DSPREQDS----ESQTLDKVYQ--MKSKPRGYCLIINNHNFA--KAREKVPKLHSIRDRN GTHL-DAGALTTTFEELHFE-IKPHDDCTVQQIYEILKIYQLM-D-HSNMDCFICCILSH GDK-------GIIYGTDGQ----EAPIYELTSQFTGLKCPSLAGKPKVFFIQACQG---D NY-QKGIPVE--TDS--------------EE-QPYLEMD----LSS-------------- PQTRYIP-----DEADFLL---GMATVN--N--CVSYRNPAEGTWYIQSLCQSLRER--- -C--PRGDDIL--TILTEVNYEVSNKD-----D--KKNMGKQMPQPTF-----TLRKKLV FPSD----------------- >A_gambiae_AGAP011951-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ECYD--TSNARRGIALIINQVIFS--S----------MAVRV GSSK-DRTDISTVLQRIGFE-VRVMDDPNRKQLLSALKQLAGE-D-HSHSDCLVVVVMTH GKEN------NLLYASDK-----SYEANQLWEPFIGDACPSLIGKPKLFFVQACRG---K KL-DEGVIQA--TIS-----------------IDSVDTQS---SPG-------------- SMRYVIP-----AMADLLV---MYSTYD--G--HYSWRNPSKGSWFIQSLCAELGAS--- -A---HCKELL--HILTAVSRRVAYHYQSNVPDNAKIDAKKQMPCMVS-----MLTKLLY LRPKK---------------- >H_sapiens_ENSP00000351273 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRM----LEES NLS-------------FLKELLFR--INRLDLLITYLNTRKEEMERELQTPGRAQ---IS AY--------------------------------R------------------------- -----------VMLYQISEEVSRSELRSF-KFLLQEEISKCKLDDDMNLLDI-------- ------------------------------------------------------------ ---------------------------------------------------FI-EMEKRV ILG-EGKLDILKRVC------------------------------------------AQI NKSLLKIINDYEEFSKERSSSLEGSPDEFSNG-------EELCGV--------------- --------------------------------------------------------MTIS DSPREQDS----ESQTLDKVYQ--MKSKPRGYCLIINNHNFA--KAREKVPKLHSIRDRN GTHL-DAGALTTTFEELHFE-IKPHDDCTVEQIYEILKIYQLM-D-HSNMDCFICCILSH GDK-------GIIYGTDGQ----EAPIYELTSQFTGLKCPSLAGKPKVFFIQACQG---D NY-QKGIPVE--TDS--------------EE-QPYLEMD----LSS-------------- PQTRYIP-----DEADFLL---GMATVN--N--CVSYRNPAEGTWYIQSLCQSLRER--- -C--PRGDDIL--TILTEVNYEVSNKD-----D--KKNMGKQMPQPTF-----TLRKKLV FPSD----------------- >T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------MSANGPASGEDFTDASK------------------ ------------------------------------------------------------ ------------------------------------------------------GGEQPS GSS-SSGKMTVDA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------KSARYSFRYS--LDFPNLGHCIIINNKNFD--RRTG-------MNTRN GTDV-DAANAMKVFSNLGYR-VRVHNDQTVAQISQLLTSAAKE-D-HSRCASFVCILLSH GDE-------GVLYGTDG-----PMEIKSLTSLFRGDRCRSLVGKPKLFFIQACRG---N DL-DGGIETD--S------------------------------IED-------------- NSTTKIP-----VEADFLY---AFSTAP--G--YYSWRNTMSGSWFMQSLCDTISKY--- -G---KELELQ--HILTRVNHKVAVEFESDS-SLPGFNAKKQIPCIVS-----MLTKEMY FS------------------- >D_rerio_ENSDARP00000071815 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSDVKPKGVDTVDARQ------------------ ------------------------------------------------------------ ----------------------------------------------------S-DAKESS SVT-DPGLVQMDAKSH-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------SDDNVDYQYK--TNYPNLGQCLIINNKNFH--KRTG-------MGVRN GTDE-DAKKVFETFSQLGFK-VGHYNDLTVSQMMALLNKASQE-D-HSKSAMFACVLLSH GDD-------GLIYGTDN-----SIELKRLFAHFRGDRCTSLVGKPKLFFIQACRG---T DL-DSGIECD--G------------------------------VGD-------------- EETQRIP-----VEADFLY---AYSTAP--G--YYAWRNVANGSWFISSLCDMLLKY--- -G---KQLEIM--QVMTRVNHKVALEFESSS-NLPGFDGKKQIPCIVS-----MLTKELY FPK------------------ >D_melanogaster_FBpp0084848 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------MDATNNGESADQVGIRVGNPEQPNDHTDALGSVGSGGAGSSGLVAGSSHPYG SGA--------------------------------------------------------- ---------------------------------------------------IG-QLANGY SSP-SSSYRKNVAKM--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VTDRHAAEYN--MRHKNRGMALIFNHEHFE--VPT--------LKSRA GTNV-DCENLTRVLKQLDFE-VTVYKDCRYKDILRTIEYAASQ-N-HSDSDCILVAILSH GEM-------GYIYAKDT-----QYKLDNIWSFFTANHCPSLAGKPKLFFIQACQG---D RL-DGGVTMQ--R--------------------SQTETD----GDS-------------- SMSYKIP-----VHADFLI---AYSTVP--G--FYSWRNTTRGSWFMQSLCAELAAN--- -G---KRLDIL--TLLTFVCQRVAVDFESCTPDTPEMHQQKQIPCITT-----MLTRILR FSDKQLAPAGRV--------- >D_rerio_ENSDARP00000083664 ------------------------------------------------------------ --------------------------------------MLGECGMTKWERLA----LRRN SVK-------------MLQDLVVD--DLLIQCLQQDG----------------------- ------------------------------------------------------------ -----------ILTDSMAESIMAKPTSQG---RSHQLLFLLPKRGPRAFSTF-------- ------------------------------------------------------------ ---------------------------------------------------CS-ALKETE QHH-LCKLLMDFTEK--------------------------------------------- --DKKNSQYKLSPEIC-----------------KKKNKHTHTH-KSMEMCLD-ADSP--- --------------------------------------------------------VTTA VLPCTPEF----YQSHRPQAYP--MRSCPRGLALVLSNVRFD-SANTD-------LDIRR GGEV-DEETLRRLFTELDFK-VSLHRDLTAEAMRRCLEQFAQQQE-HAAYDCAVVCLLSH GVE-------GSVYGTDGQ----LLELDWVFEVFDNARCPLLQNKPKMFFIQACRG---E EM-DNGVDQL--DGQER----------TQSPGCEQRDAG----REGERDNREKKEEKERE RLRVKLP-----QRSDMIC---GFATLK--G--TAAMRNTKKGSWFIQELNTAIRQR--- -A---NNTHLS--DILVQVNGQIKSREGYA--PGSAHHRCKEMSEFTS-----SLCKDLY LFPKYYPSN------------ >T_guttata_ENSTGUP00000013612 ------------------------------------------------------------ --------------------------------------MLAACGMQRCHQEA----LKKN RVM-------------LAKQLVLN--VLVEHMVEKD------------------------ ------------------------------------------------------------ -----------IIPTEMVEMIQAKSGSFD---RNVEFLNLLPKRGPNAFSAF-------- ------------------------------------------------------------ ---------------------------------------------------CE-ALRETQ QQH-LETLILKTMSS---------------LS--------------QEI--------ARL EHCHESDLPYPASESCNSK--------------RPRWL------EPMEHSLDNRDGP--- --------------------------------------------------------SIPP VKYCTPEF----YHNHQHLAYK--LTSEPRGLALILSNVRFS--SEKD-------LEYRA GGDV-DCASLEMLFRHLGYR-VTVFCDQTAQDMQNALERFSKLQD-HRDVDSCIIALLSH GVE-------GGVYGSDGK----LLELQETFRLFDNANCPNLQNKPKMFFIQACRG---D EL-DRGVDQR--DGKGR----------SDSPGCEESDAN----KEE-------------- SLKLRLP-----TCSDMIC---GYACLK--G--TAAMRNTKRGSWYVEALTSVFAED--- -S---QHTHVA--DMLVKVNRQIKQREGYA--PGTEYHRCKEMSEYCS-----TLCRDLY LFPGYLPGK------------ >C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSA--TCGLRRAY----------------------------------- ------------------------------------------------------------ -----------------------------------------------------------R TAD-EQNVTETDAFY--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----K-R----EMFDPEEKYK--MDHKRRGIALIFNHERFF--WHLT-------LPDRR GTSA-DRDNLVRRFSELGFE-VKCFNDLKAEELLLKIHEASTS-S-HIDADCFLCVFLSH GEG-------NHIYAYDA-----KIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRG---D QH-DVPVLPL--DVVDH-----------RTDKLEDNVTE----VDA-------------- ASVYTLP-----AGADFLM---CYSVAE--G--YYSHRETVNGSWYIQDLCEMLGKF--- -G---SSLEFT--ELLTLVNRKVSQRRVDFC-KDPNAIGKKQVPCFAS-----MLTKKLH FFPKSK--------------- >C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MGEQRNTSSKELAAAEATGQSGKELEVSMENTENSVDAKS------------------ ------------------------------------------------------------ -------------------------------------------------------FKNAE TVI-V---KILK------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DKYLTKLHYK--MDYPEMGLCIIINNKNFH--KSTG-------MAPRS GTDV-DAANLRETFTNLKYE-VRNKNDLTCEEILELMNSVSKE-D-HSKRSSFVCVLLSH GDE-------GIIFGTNG-----PVDLRKVTGFFRGDYCRSLTGKPKLFIIQACRG---T EL-DCGIETD--SGI----------------------------EDD-------------- MACQKIP-----VEADFLY---AYSTAP--G--YYSWRNSKDGSWFIQSLCAMLKLY--- -A---HKLEFM--HILTRVNRKVATEFESFS-LDSAFHGKKQIPCIVS-----MLTKELY LYH------------------ >G_gallus_ENSGALP00000019870 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MSGAERRPAAGRVQLD------------------------------- ------------------------------------------------------------ ---------------------------------------------------SK-PTPTTT ADG-NQNITEVDAFD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----K-R----QTFDPAVQYK--MNHQRRGVALIFNHEHFF--WHLR-------LPDRR GTLA-DRNNLKRSLTDLGFE-VRIFDDLKAEDVLKKVFEASRD-D-YSNADCFVCVFLSH GEN-------DHVYAYDA-----QIKIETITNMFRGDKCQSLVGKPKIFIIQACRG---D KH-DDPVLVQ--DSVDS------------KDETTVNQTE----VDA-------------- AGVYTLP-----AGADFIM---CYSVAQ--G--YFSHRETVNGSWYIQDLCEALGKH--- -G---SSLEFT--ELLTVVNRKVSHRKVDIC-RDINAIGKKQIPCFAS-----MLTKKLY FHPKSK--------------- >B_taurus_ENSBTAP00000038128 -----------------------------------------------------------M ALTQCLYNIGEQLGSDDLAALKFLSRDHIPYRKQEPIKDALMLFQRLQEKRM----LEEN NLS-------------FLKELLFR--VNRLDLLLNYLYTSEEEMKRELQIPGRAQ---IS AY--------------------------------R------------------------- -----------ILLFQISEDVNKVELKDF-KFFLSQEIAKCKLDDDMTLLDI-------- ------------------------------------------------------------ ---------------------------------------------------FV-EMEKRT ILG-EENLDTLKRIC------------------------------------------EQV NKSLLKKIYDYEELRKERRMSLERDPYAFSNDMSQSLPEEGYSKM--------------- --------------------------------------------------------PAMS DSP-EQDS----ELQTSDTVYR--MTSKPRGYCLIFNNYDFS--IARKQVPELHDLKDRT GTDF-DADALDKTFRELHFE-IVHYKDLTAKGICEVLESYQKK-D-HKNKDCFICCILTH GNK-------GIIYGSDGQ----EASIYELTSYFTGLKCPSLIGKPKIFFIQACQG---D KY-QKGVAVE--TDS--------------EQMEAYLEVD-----SS-------------- PQKRYIP-----DEADFLL---GMATVK--N--YVSYRNIWNGAWYIQSLCQNLRER--- -C--PRGEDIL--TILTKVNFEVSKLD-----D--KQRMAKQMPQPTF-----TLRKKLF FPLN----------------- >O_latipes_ENSORLP00000015114 ------------------------------------------------------------ ------------------------------------RSVTQKCGMQKRDAEA----LRNC SVC-------------LLKDLVVD--ELLIQALVKDG----------------------- ------------------------------------------------------------ -----------ILTQNMAESIMVQKTSHH---RSFKLLLLLPKRGPRAFKSF-------- ------------------------------------------------------------ ---------------------------------------------------CS-ALKETE QEH-LCDLLTQ--EE---------------EG--------------REVCLDTPLINSEE QSEVSSSMSYPIHDSE-----------------GLQLEMRTNT-ESMESSLD-ADSP--- --------------------------------------------------------INTP VLACSADF----YLSHCQQSYR--MNSSPRGSVLVISNINFDPRAAPE-------LDPRK GGEV-DDEVLRKLFTELDYS-VNFHRDLTAQDMKMVIENFCRRPD-HQKVDSCVVCLLSH GVD-------GAIYGTDGQ----QLALDWVFEAFDNAHCPLLQNKPKMFFIQACRG---D EM-DCGVEQI--DGPAR----------TFSPTCEQRDAG----REEQGD-ADGRQRASTG RQRIKLP-----QRSDMIC---GFASLK--G--TAAMRNTKKGSWFIQELNTALRLN--- -A---RDTHLA--DILVQVNKRIKEREGYA--PGTAHHRCKEMSEFTS-----SLCKDLY LFPKYQPQC------------ >C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MADDQDCGMEQAAGDSESPDAVDARPDRSSFVPSL--------- ------------------------------------------------------------ ---------------------------------------------------FS-RKKKND SGR-SIKTA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------QDQVPTYQYN--MNFEKVGKCIIINNKNFD--KTTG-------MGVRN GTDK-DAEALFKCFRNLGFD-VVIYNDCSCAKMQDLLKKASEE-D-HRNSACFACILLSH GEE-------NLIYGTDG-----MTAIKDLTAHFRGDRCRTLLEKPKLFFIQACRG---T EL-DDGVQAD--SGPIN-D------------------------TDA-------------- NPRYKIP-----VEADFLF---AYSTVP--G--YYSWRSPGSGSWFVQALCSTLNEH--- -G---KSLEIL--HILTRVNNRVARHFESQS-DDPHFHEKKQIPCVVS-----MLTKELY F-------------------- >G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MADDQGCVXXXXXXXXXXXXXXXXXXXXXXXXXXX--------- ------------------------------------------------------------ ---------------------------------------------------XX-XXXXXX XXX-XXXXX--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------XXXXXXXXXX--XXXXXXXXXXXXXXXXFD--KVTG-------MGVRN GTDK-DAEALFKCFRSLGFD-VIVYNDCSCAKMQDLLKKASEE-D-HTNAACFACILLSH GEE-------NVIYGKDG-----VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG---T EL-DDGIQAD--SGPIN-D------------------------TDA-------------- NPRYKIP-----VEADFLF---AYSTVP--G--YYSWRSPGRGSWFVQALCSILEEH--- -G---KDLEIM--QILTRVNDRVARHFESQS-DDPRFHEKKQIPCVVS-----MLTKELY FSQ------------------ >B_taurus_ENSBTAP00000021099 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MENTENSVDSKS------------------ ------------------------------------------------------------ -------------------------------------------------------IKTSE TKI-LHGSKSMD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SGISLEESYK--MDYPEMGLCIIINNKNFH--ENTG-------MCRRS PTDD-SVAQXRETFMNLKYE-VRIKNDLTCKEMLELMSNVSKE-D-HSKRSSFICVLLSH GEE-------GIIFGTNG-----PVNLKKLASFFRGDYCRSLTGKPKLFIIQACRG---T EL-DCGIETD--SGA----------------------------EDD-------------- MACQKIP-----VEADFLY---AYSTAP--G--YFSWRNAKNGSWFIQALCEMLKKH--- -A---HRLELM--HILTRVNRKVAIEYESFS-TDSAFHAKKQIPCIMS-----MLTKELY F-------------------- >P_pygmaeus_ENSPPYP00000014606 -----------------------------------------------------------M DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRM----LEES NLS-------------FLKELLFR--INRLDLLITYLNTRKEEMERELQTPGRAQ---IS AYRFHFCRMSWAEANSQCQTQSVPFWWRVDHILIR------------------------- -----------VMLYQISEEVSRSELRCF-KFLLQEEISKCKLDDDMNLLDI-------- ------------------------------------------------------------ ---------------------------------------------------FI-EMEKRV ILG-KGKLDILKRVC------------------------------------------AQI NKSLLKIINDYEEFSRG----------------------EELCGV--------------- --------------------------------------------------------MTIS DSPREQDS----ESQTLDKVYQ--MKSKPRGYCLIINNHNFA--KAREKVPKLHSIRDRN GTHL-DAGALTTTFEELHFE-IKPHNDCTVEQIYEILKIYQLM-D-HSNMDCFICCILSH GDK-------GIIYGTDGQ----EAPIYELTSQFTGLKCPSLAGKPKVFFIQACQG---D NY-QKGIPVE--TDS--------------EG-QPYLEMD----LSS-------------- PQTRYIP-----DEADFLL---GMATVN--N--CVSYRNPAEGTWYIQSLCQSLKER--- -C--PRGDDIL--TILTEVNYEVSNKD-----D--KKNMGKQMPQPTF-----TLRKKLV FPSD----------------- >T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------TNMSANGPSPGGDFTDAKKG----------------- ------------------------------------------------------------ ------------------------------------------------------AGQQPR SGS-SSGRVTVDA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------KPAAYSFRYS--LDFPNMGHCIIINNKNFD--RRTG-------MNTRN GTDV-DAANAMKVFLSLGYK-VKVHNDQTVNQMKQLLVSAAEE-D-HSACASFVCVLLSH GDE-------GVFFGTDG-----SVELKYLTSLFRGDRCKSLVGKPKLFFIQACRG---N DL-DGGIETD--S------------------------------AAD-------------- SSTTKIP-----VEADFLY---AFSTAP--G--YYSWRNTTSGSWFMQSLCDAISKY--- -G---KELELQ--HILTRVNHKVAVDFESVS-NLPGFDAKKQIPCIVS-----MLTKEMY FS------------------- >M_domestica_ENSMODP00000007353 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------KSFGLFFVF----------------------------------- ------------------------------------------------------------ -----------------------------------------------------------E GDA-EQNATEIDAFF--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----K-S----KPLDPAEQYK--MDHKRRGVALIFNHERFF--WHLT-------LPERR GTRA-DRDNLRQRLSDLGFE-VNCFDDLKAEDLLMTIHMVSTS-S-HIDADCFLCVFLTH GEG-------NHIYAYDA-----KIDIQKLTAMFKGDKCQTLVGKPKIFVIQACRG---D QH-DIPVIPL--DVVDH-----------LSDKVDVNETE----VDA-------------- ASVYTLP-----AGADFLM---CYSVAE--G--YYSHRETVHGSWYIQDLCEMLEKY--- -G---SSLEFT--ELLTLVNRKVSQRRVDFC-KDPNAIGKKQVPCFAS-----MLTKKLY LFPKPK--------------- >T_guttata_ENSTGUP00000004278 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MSGSERRPPAGHVQLD------------------------------- ------------------------------------------------------------ ----------------------------------------------------S-RPTLPT TDG-NENITEVDALN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----I-R----QSLDPAEEYK--MNHQRRGLALIFNHERFY--WHLR-------LQDRR GTWV-DRNNLKSILTELGFE-VRLFDDLKKEDVQQRIYEASTA-D-HSNADCFVCVFLSH GED-------GHIFAYDD-----KIEIQTITDMFRGDKCQSLVGKPKIFIIQACRG---D KH-DDAVIAH--DSADG-------------SESPGNETD----VDA-------------- AGVYTLP-----AGADFIM---CYSVAQ--G--YYSHRDTINGSWYIQDLCETLRKH--- -G---SSLEFA--ELLTVVNRKVSCRRVGMC-KDINAIGKKQIPCFAS-----MLTKKLY FHPKSK--------------- >M_musculus_ENSMUSP00000029626 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------MTETDGFY--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----KSR----EVFDPAEQYK--MDHKRRGVALIFNHERFF--WHLT-------LPERR GTNA-DRDNLTRRFSDLGFE-VKCFNDLRAEELLLKIHEVSTS-S-HIDADCFICVFLSH GEG-------NHVYAYDA-----KIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRG---S QH-DVPVVPL--DMVDH-----------QTDKLD-NVTQ----VDA-------------- ASVYTLP-----AGADFLM---CYSVAE--G--YYSHRETVNGSWYIQDLCEMLARY--- -G---SSLEFT--ELLTLVNRKVSQRRVDFC-KDPDAIGKKQVPCFAS-----MLTKKLH FCPKPSK-------------- >G_gallus_ENSGALP00000002083 ------------------------------------------------------------ --------------------------------------------MEEAQRSA----LRRG RVR-------------LVEGLRPE--VLWGPLQARG------------------------ ------------------------------------------------------------ -----------VFTSAMVEDMQST--GTR-REQARQLVIDLETRGKQAFPIF-------- ------------------------------------------------------------ ---------------------------------------------------LS-ILRDTG HGD-LADMLDEGCGS------------------------------------------PMS PPV--DLRPVQLELP--------------------------GERRDKSVSTAERLSIPVQ PESERFR-------------------------------------------------MPPA PAQACPTG----LAGECSEVYQ--LRADPCGHCLIFNNVSFS--RDSD-------LSTRA GSDI-DCEKLEKRFRSLCFH-VRTLRNLKAQEIDVELRKLARL-D-HSALDCCLVVILSH GCQTSHIQFPGGIYGTDGK----IIPIERIVNYFNGSQCPSLRGKPKLFFIQACGG---E QK-DQGFEVD--CESPQDETCRRSIESDAIPFQAPSGNE----DEP-------------- DAVASLP-----TPGDILV---SYSTFP--G--FVSWRDKVSGSWYVETLDSVLEHY--- -A---RSEDLL--TMLLRVSDIVSTK-----------GRYKQIPGCFN-----FLRKKFF FLCK----------------- >A_carolinensis_ENSACAP00000001629 ------------------------------------------------------------ -FRQILLAIDENLGKEDVDAMKFLCSDFISTKHLEGVETAQDIFQLLINRNL----LSKE DTF-------------IVAELLYR--IKCHFLL-QKIGYTQQKVEHNLFHIRN-----VS EY--------------------------------R------------------------- -----------QMLYEISEGFTEENVKTA-MFLLREHLPKKQ----SIAVKL-------- ------------------------------------------------------------ ---------------------------------------------------LT-SLEKQD LLA-EDKLAILEKIC------------------------------------------NKV SPELRNKVDKFKERSVFKAFVF--------------SLCYENLYPSNFLAVFLL------ ------------------------------------------------------------ -------------ILQASTCYK--MDGLNRGSCLIFNNVHFE--GG---------LSQRR GSQK-DAEELESVFRWLGLD-VIKYNDTTSIEMENHLKQWQSFEN-WKDMDCLVCCILSH GES-------GKIYGTDGN----LIPIRTIMSYFTAKQCPQLAKKPKLFFIQACQG---E KT-QQPVYLE--TDD--------------EYGSFPLQ----------------------- QMISSIP-----EEADFLL---GMATVD--G--YLSFRHVHQGTWYIQALCDKLRTL--- -V--PRGEDIL--SILTEVNADVSRRA-----D--AQGQKKQMPQPAY-----TLRKKLI FPIP----------------- >M_domestica_ENSMODP00000036247 -----------------------------------------------------------M DFHTFLYGIAEEIDSADLASLKFLCLDQIPLKKQQHIKDALVLFQTLEERGL----LEED NLF-------------FLKELLFR--INRIDLLNEPLNTKGPEMERELQVPNKAR---IS PY--------------------------------RLHLHTTIWPFRDNWTCRITLSVSFT SRTKQLLSVMVILLFNLSEGVGPSELKSI-KFMLSSKIPKCKIEDDMTLMDL-------- ------------------------------------------------------------ ---------------------------------------------------FI-EMEKRG ILG-EGNLDALKIVC------------------------------------------DQI DKSLLKKIQEYEISKGRNNLFL-------------------------------------- --------------------------------------------------------IYQN TQPQEVYD----SAGEKGNVYK--MSSRPRGYCLIINNFDFK--ISRKERPENHYLTDRR GTNK-DEEALKNIFKELHFD-IQSFQDLTAEGIQQVLKTFKDN-N-HESKDCFVCCLLSH GNK-------GTIYGIDGK----EVPIRDLTSYFSGSNCPSLAGKPKVFFIQACQG---K AT-QYGISLD--TDS--------------EQQRESLEAD-----KS-------------- FQSECIP-----NEADFLL---GMATVE--N--YVSYRDSARGTWYIQSLCKNLKEG--- -C--LRGNDIL--TILTEVNSEVSQKT-----D--PKNNGKQMPQPKI-----TLRKKLV FPIS----------------- >O_anatinus_ENSOANP00000005545 ------------------------------------------------------------ --------------------------------------------MQPCHQEA----LKKN RVA-------------LAKQLMLS--ELLEHLLEKD------------------------ ------------------------------------------------------------ -----------VITMEMRELIQAKAGSFS---QNVEFLNLLPKRGPKAFDAF-------- ------------------------------------------------------------ ---------------------------------------------------CA-ALRETK QGH-LQDLLYRTLSN---------------LSPPSTAVGALGTQGEELA--------GRL GGRWRGLPSLPSVSVCPVVVCPFLMVLGNSRLQPALSVGDLLP-EEMEHSLDNGDGP--- --------------------------------------------------------PCPQ VKPCTPEF----YRVHHHLAYR--LESRPRGLALVLSNMRFN--GEKD-------LEFRS GGDV-DHNALITLFKHLDYS-VEFLRDQTAQEMQEKLHNFAQSPR-HRFTDSCVVALLSH GVE-------GGIYGVDGK----LLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG---D ET-DRGVDQR--DGKER----------AASPGCEESDAG----KEE-------------- MLKVRLP-----TRSDMIC---GYACLK--G--TAAMRNTKRGSWYIEALTQVFAES--- -A---RDMHVA--DMLVKVS---------------------------------------- --------------------- >M_mulatta_ENSMMUP00000037892 VEGGRRARVVTESKRNFFLGACPTPFPTEHVELGRLGGSETAMVPGKGGADYILLPFEEM DFNRNLYDIGEQLDSEELASLKFLSLDCIPQRKQEPIKDALMLFQRLQEKRM----LEEN NLS-------------FLKELLFR--INRLDLLTTYLNTRKEEMERELQAPGRAQ---IS AY--------------------------------R------------------------- -----------VMLYQISEEVGRSELRSF-KFLLQEEISKCKLDDDMNLLDI-------- ------------------------------------------------------------ ---------------------------------------------------FV-EMEKRV ILG-EGKLDILKRVC------------------------------------------AQV NKSLLKIINDYEEFSRERTRSLEGSPEEGSNG-------EELCGL--------------- --------------------------------------------------------MTIS DSPREQDS----ESQTLDKVYQ--MKSKPRGYCLIINNYDFT--KAREKVPKLHSIRDRN GTHL-DAEALTATFEELHFE-IQHHNDCTVEKIYKILKTYQLM-D-HSNKDCFICCILSH GDK-------GIIYGTDGQ----EAPIYELTSQFTGLKCPSLAGKPKVFFIQACQG---D NY-QKGIPVE--TDS--------------EE-QPYLEMD----LSS-------------- PQTRYIP-----DEADFLL---GMATVN--N--CVSYRNPAEGTWYIQSLCQSLRER--- -C--PRGDDIL--TILTEVNYEVSNKD-----D--KKNMGKQMPQPTF-----TLRKKLV FPSD----------------- >A_gambiae_AGAP004921-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RSCNLMDDLPPEPTPDNEFYD------- ------------------------------------------------------------ ---------------------------------------------------GN-IPSITQ TDQ-IASRQRSQN----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------ARALQEEEYD--TNHRRRGMAIILNHENFE--L----------MSKRE GTNR-DRDAATAVLTSMQFD-VRVYNDLGRDELFCVLLALASE-D-HSDCDCLLVMLMTH GDD-------DVLYAYDG-----PYSVDKLWESFMGNACTTLLGKPKLFFVQACRG---S TF-DKGVKLG--C--------------------RDLDSD----HFS-------------- SHKYVIP-----TTADLLV---MYSSYK--G--HVSWRSPRGGSWFIQALCVELETN--- -W---KHMELL--QLLTGVSRRVAYDYQSNEPSKGRMDAMKQMPSIVS-----MLTKLVY FPLKLGS-------------- >A_aegypti_AAEL003444-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MDTTDELD------------------ ------------------------------------------------------------ ------------------------------------------------------VLGFGS RTN-ESSKSIKEALV--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------SRAALDEYYD--TTNKRRGIALVFCHMNFS--V----------MAKRN GADK-DRDDICNTLYGLDFD-VRVFDDLSRKEVLDRLKDVSRE-D-HSDNDCLVVVMMSH GEQ-------GVLYARDN-----KYNVDSLWKNFVGNACPSLIGKPKMFFIQACRG---E QF-DEGVAYA--AKS-----------------PKDMVDS----RQE-------------- QVLYSIP-----AMADLLV---MYSTYD--G--YYSWRNPRQGSWFIQSLCTELDEN--- -G---RVRDLL--TLLTGVSRRTAYEFQSFVPHNAKMDAMKQIPCIVS-----MLTKTFY FTKKTRSRVVTDID------- >G_aculeatus_ENSGACP00000013740 ------------------------------------------------------------ ------------------------------------------CGMQERDRLA----LRTR STV-------------LCKQLVVD--ELLIQSLQTDE----------------------- ------------------------------------------------------------ -----------ILTEAMAENIMAEQTSQK---RSWRLLLLLPKRGPRAFSSF-------- ------------------------------------------------------------ ---------------------------------------------------CS-ALQETE QQH-LYELLIQSSEK---------------DG--------------KETPGM-----LMC GQFIDSSLPLPTQEVV-----------------AAKRARTQA--ESMEFSLD-ADSP--- --------------------------------------------------------INSP VLPCTPDF----YLSHCHQSYR--MNSSPRGFALVISNVTFDPCAAPD-------LDPRK GGEV-DDEVLRKVFTELDYV-VKVHRDLTAQDMRTCIEEFSRRPD-HRTMASCVVCLLSH GVE-------GAIYGTDGQ----LLKLDWVFESFDNAHCPLLQNKPKMFFIQACRG---E EM-DCGVEQI--DGPVR----------TCSPSCEQRDAG----REGQGD-ASARQRGD-- MGRIKLP-----QRSDMIC---GFASLK--G--TAAMRNTKRGSWFVQELNKRLRLH--- -A---RDTHLA--DIMVQVNRHIKEREGYA--PGTAHHRCKEMSEFTS-----SLCKDLY LFPKYQPQ------------- >O_anatinus_ENSOANP00000005811 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PRGATRLARGH----------------------------------- ------------------------------------------------------------ ----------------------------------------------------------PA AGG-APNVTEVDGFY--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----D-R----ETFDPAAKYK--MEYKRRGVALIFNHERFY--WQLK-------LPDRH GTRA-DRENLIRRLSALGFE-VKCFDDLKAEEVMLKIHQASSS-N-HADADCFLCVFLSH GQG-------NHVYAYNG-----KIDIPEMTSMFKGDQCRSLVGKPKIFIFQACRG---E QH-DVGVVPL--DVVDS-----------KISEQDVNETE----VDA-------------- ASVYTLP-----AGADFLM---CYSVAE--G--YYSHRETVNGSWYIQDLCEMLGRY--- -G---SSLEFT--ELLTLVNRKVSYRRVDFC-KDPSLIGKKQVPCFAS-----MLTKKLH FLPKAQ--------------- >D_rerio_ENSDARP00000075318 ------------------------------------------------------------ ------------------------------------------------MADQLLENLRPD LIK-------------GLSERVIN--GLLDDLQQKK------------------------ ------------------------------------------------------------ -----------VFGEEEIEDIQHRMKTRA--DQARHVIDDVKRKGVKASEIM-------- ------------------------------------------------------------ ---------------------------------------------------LA-SLKTRD PHL-YDTLGIERLLV------------------------------------------PVP ETELT------------------------------------------------------- --------------------------------------------------------PSQL SETTGCST----DKTNTMNEYE--MKSNPRGLCLIFNNENFK--DP---------DMKRH GSQM-DTASLKDLFEWLGFS-VEIKQDQTVSAMKRTLKEYSE--D-RKHGDCFVCCVLSH GNE-------SGVLGSDEK----ICPVDDITSPFNGANCSSLAGKPKVFFIQACRG---H EI-QSKVMVA--DGS------------------GGSRTQ----KPG-------------- RVSVSIP-----KDSDFLI---ARSTVE--G--YVSIRDRTSGTWFIQSLCENLKEG--- -S--KRGHDIL--MILTKVNNDVSRKEGSLK-VKNEIVDAKVTPQPIF-----TLRKLLI FRPLKKTGRFS---------- >P_pygmaeus_ENSPPYP00000002138 ------------------------------------------------------------ --------------------------------------------MDEADRRL----LWRC RLR-------------LVEELQVD--QLWDALLSRE------------------------ ------------------------------------------------------------ -----------LFRPHMIEDIQRAGSGSR-RDQARQLIIDLETRGSQALPLF-------- ------------------------------------------------------------ ---------------------------------------------------IS-CLEDTG QDM-LASFLRTNRQA------------------------------------------AKL ------------------------------------SKPTLENLTPVVLRPEIVRPEIRK PEVLR-PETPRPVDIG----------------------------------------SGGF GDVGALES----MRGNADLAYI--LSMDPCGHCLIINNVNFC--RESG-------LRTRT GSNI-DSEKLRRRFSSLHFM-VEVKGDLTAKEMVLALLELAQQ-D-HGALDCCVVVILSH GCQASHLQFPGAVYGTDGC----PVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGG---E QK-DHGFEVA--STSPEDESPGSNPEPDATPFQEGLRTF----DQL-------------- DAISSLP-----TPSDIFV---SYSTFP--G--FVSWRDPKSGSWYVETLDDIFEQW--- -A---HSEDLQ--SLLLRVANAVSVK-----------GIYKQMPGCFN-----FLRKKLF FKTS----------------- >T_rubripes_ENSTRUP00000024164 ------------------------------------------------------------ -------------------------------------------VFLPKDMEA----VRRN KTA-------------IGTIFCADYGLILNKVDEKK------------------------ ------------------------------------------------------------ -----------LITRRDYNNLKNINGEDI-WGHVIALVDKIMNKGDATCEAF-------- ------------------------------------------------------------ ---------------------------------------------------LN-LLQTDD DIK-STYPELKDTHFNIFF----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------FFYLQDEQYE--LLSQPTGLCVIINNENFL--D----------MKQRS GTNK-DAQSLAEVFTWLGFR-VLMCKDQTKEKMDRALNCFASLVD-PKHGDAFICCILSH GEK-------SAVLGIDGE----PLCIKQIIRTFKATRQSALVSKPKMFLIQACQG---K GT-HRGVLLK--D------------------------LQ----TDD-------------- CHTLSIP-----EEADILV---ATATVE--D--YVSFRHKIDGSWFIQSLCQELKEG--- -C--LRGEDMT--TILHRVNSEVSQKE-----AFIHPGEQKQMPEVRF-----TLRKRLV LSPHTA--------------- >T_nigroviridis_ENSTNIP00000001216 ------------------------------------------------------------ --------------------------------------SAYQLFLSLCDQDH----LSEE RPH-------------LLSELLSI--IQRTRLL------------RDLDLRSSATSNLIS AY--------------------------------R------------------------- -----------KLLYSLSEDLTDDNLKEI-KFLLTETLPRRKLEDNVTTLEV-------- ------------------------------------------------------------ ---------------------------------------------------FL-ELECMD LLS-KTNLGLLKSIL------------------------------------------QPV CPVLAERIRQFEAQNSCQ---------PAADWGFAVKKITDPLQVQGGSDALPSLPEENQ SSSRTEASVMSSANAVGIKPGTLM--------------------------------LGLS PPPVGSPN----FPVQDLGTYP--MTTLPRGCCLIISNYDFQ--GSG--------LGMRN GTRT-DEECLKKVFEWLGFK-VEIHRDCTGKEILSLMQELADK-S-QQRWDCLVCCILSH GLE-------GCVHGVDGD----QVSIKKLIEPFLGTNCPAMAGKPKLFFIQACQG---K KQ-QGVVHLE--SDG---------------AEHSDVDTD-----AV-------------- RLSNCIP-----SHADFLL---GMATVP--D--YVSYRDRERGTWYIQSLCEYLVKM--- -V--PRGFDLM--SILTKVNEDVSKKN-----D--NTGDRKQMPQPVF-----TITKRIV FPVPSGPAPVLPHFPFVEDSP >C_familiaris_ENSCAFP00000017933 ------------------------------------------MTSQAQSLTFRSDDNCQS SFRGKLLTIDSKLEIQDVEGLKFLCRDFVSHKKLEKSNSASDIFDHLLAEEL----LSEE DPF-------------FLAELLYI--IKQNSLL-RYLNQSKEQVESLLPTRRR-----VS LF--------------------------------R------------------------- -----------NLLYELSESIGSENLKDM-IFLQRDSMPKTQ----LTPLSF-------- ------------------------------------------------------------ ---------------------------------------------------LA-YLEKQA LID-EDNLGLLEDLC------------------------------------------RKV VPNLIRKIERYKREKASEVVTP-----PVDTETESLHQKEEELFSPSDINQFHGALSKQT SWNPLKHRAKQGNIISDGA-TLVSVE------------------------------MLEA STGPLTSE----TSTKEANVYR--MDRKHRGHCVIVNNHTFA--K----------MPDRP GTDK-DAECLSRVFQWLGFS-VHVYKNVTKGHLDEVLQEFKCHPD-HVDGDCFVFCVLTH GKF-------GAVYSSDGT----LVPIREIMSHFTAQKCPGLAHKPKLFFIQACQG---K GI-QTPVSIE--ADA--------------VNPEHVSP----------------------- SLKDSIP-----DAADFLL---GLATVP--G--YVSFRHVEKGSWYIQSLCNRLKSL--- -V--PRHEDIL--SILTAVNNDVSQQA-----D--KQGTMKQMPQPAY-----TLRKKLV FPVPQKELLL----------- >C_familiaris_ENSCAFP00000017899 -----------------------------------------------------------M DFSKCLYNIGEQLDSDELASLKFLSLDYIPQKKQEPIKDPLMLFQRLQEKRM----LEES NLF-------------FLKELLFR--INRLDLLMTYLDTSKEDMQQELQIPGRAQ---IS AY--------------------------------R------------------------- -----------VMLFQISEDVSKLELKSF-KFLLSREISRCKLDDDLNLLDI-------- ------------------------------------------------------------ ---------------------------------------------------FI-EMEKRV ILG-ERNLDTLKRIC------------------------------------------DQI NKSLLKKITDYEELNREQTMNLQRSLDEISNDMSQLPIREGSVKI--------------- --------------------------------------------------------LPMS DSLGEQDY----ESETSDKVYR--MKSKPRGYCLIFNNYDFS--VARREVPKLQSIKDRN GTDL-DADALSKTFSELHFE-IVHFKDATAKKICEVLQSYQSM-D-HSSKDCFICCILSH GDK-------GIIYGSDGQ----EAPIYELTSYFTGSKCPSLAGKPKIFFIQACQG---D KY-QKGIAVE--TDS--------------EQKEAYLEMD-----SS-------------- YQKRYIP-----EDADFLL---GMATVN--N--CVSYRNPMEGTWYIQSLCQSLRER--- -C--PRGEDIL--TILTEVNFEVSNKD-----D--RKNMGKQMPQPTF-----TLRKKLF FPPN----------------- >A_gambiae_AGAP004920-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VCGRDILHCKTMNTSTLSTAFDEVDNNT------------------ ------------------------------------------------------------ ---------------------------------------------------RV-LSLVAS VPE-IISSSVIHE----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------LEPVDDAHYN--MSHNRRGVAAVFNHRKFL--H----------ASERK GTDA-DCDNIRQVLIYLQFE-VRVYDDLTRKEIKQVLDDLAEE-D-HKNSDCLLVVIMTH GDD-------DVLHAKDG-----TFNVDRLWENFIGDSCPSLLGKPKLFFIQACRG---S SF-DTGVHFS--QCMTQVAKTVVPYAMRELPQPSIVPGC----PKS-------------- SIQYAIP-----SMADLLV---MYSTYK--G--HYSWRNPSTGSWFIRALCDELREH--- -G---NSKELL--QLLTSVSRRVAYEFQSNVPNNSQIDCQKQMPCIVS-----MLTRRIY FSKK----------------- >T_guttata_ENSTGUP00000017449 ------------------------------------------------------------ --------------------------------------------MEERQRRA----LRRG RAR-------------LVAALRVE--PLWEPLEQRG------------------------ ------------------------------------------------------------ -----------LFTRPMLEELQSA--GSR-GEQARQLIIDLETRGKQAFPAF-------- ------------------------------------------------------------ ---------------------------------------------------LS-ILRDTG QGH-LAEMLMQECES------------------------------------------RPV PPQLPDLRPVELELQ------------------------EANQRCAVVLQTAARDVA--- --------------------------------------------------------AGIP LTVGKSPE----VMSFIILDYE--MKADPCGHCLILNNVNFC--RDSG-------LSTRE GSDI-DCEKLERRFKALCFT-VLTRRDLKAQEMVLELLKLSRQ-D-HSALDCCIVVILSH GCQTSHIQFPGGVYGTDGK----PIPIEKIVNYFNGSSCPSLRGKPKLFFIQACGG---E QR-DQGFVVD--CDSPKEEALGDSLESDAIPFRVPSDNV----DEP-------------- DAIASLP-----TPSDILV---SYSTFP--G--FVSWREKSSGSWYVETLDSVLEQY--- -A---HSEDLL--SMLVRVAHAVSAR-----------GRYKQIPGCFN-----FLRKKFF FVCR----------------- >C_familiaris_ENSCAFP00000023986 ------------------------------------------------------------ --------------------------------------------MDEAERRA----LRRC RVR-------------LVRELQVA--ALWDALLSRE------------------------ ------------------------------------------------------------ -----------LFTAAMVEDLQHAGSGSR-SDQARQLVIDLETRGSQALPLF-------- ------------------------------------------------------------ ---------------------------------------------------IS-CLEDTG QDA-LASCLTMSRQA------------------------------------------VKQ NPE--ATRPLD-LMPVVLGPTRLTPEDLR---GKDPSKLTPGKLAPVVLG-----PAELQ PQVVR-PSVPRPTDNG----------------------------------------SGRF SDVCEYQESGWWVAGPIKLAYA--LNADPCGYCLIINNVNFC--PESR-------LTARG GSNI-DCEKLQRRFCLLRFT-VEVKWDLTAKQMVQALVELARR-D-HSALDCCVVVVLSH GCEASHRQFPGAVYGTDGC----PVSIEKIVNIFNGTGCPSLGGKPKLFFIQACGG---E QK-DHGFAVA--SASPEDRSPGSDSEPDAVPFQEGPGPF----DQL-------------- DAVSSLP-----TPSDIFV---SYSTFP--G--FVSWRNTKSGSWYVETLDGVFEQW--- -A---HAEDLQ--TLLLRVANAVSQK-----------GVYKQIPGCFN-----FLRKKLY FKM------------------ >D_rerio_ENSDARP00000072390 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------AFEPY--KKHKNIGKCLIISNEHFP--VQFS-------LNRKK GNSV-DERRLSSTFKSLGFH-VKVENNLSANQMIDALRTVSEE-D-HTDNSCFVCVLMSH GEE-------GTILGSDER----WIPVKTLTSLLTSDLCPSLRDKPKIFFLQACRG---V EY-DPGVEAD--S----------------------VEAS----EDF-------------- FGISDVP------ELDFLC---CYSTVE--G--YFAWRNPETGSIFIRELCKTLMDC--- ------RLEII--QILTRVNHLVAYYFQSYT-LELETNRKRQMPCFAS-----RLTKDFY LHV------------------ >E_caballus_ENSECAP00000015102 ------------------------------------------------------------ --------------------------------------------MNEADRQL----LRRS RLR-------------LVRELQVD--SLWDALLTRE------------------------ ------------------------------------------------------------ -----------LFTPDMIEDIQR--SGSR-RDQARQLIIDLETRGSQALLLF-------- ------------------------------------------------------------ ---------------------------------------------------IS-CLEDTG QDT-LASFLRTSSQA------------------------------------------AKQ NPE--AIRPSD-LPPVVLGPVGLKPEELT-AVKQDPSKLTPGKLTPVVLGPEELWLAKLR PEVLR-PEVPRPVDIG----------------------------------------SGGF SDVRAQDR----LRGNADLAYV--LNADPCGHCLIINNVNFY--LASG-------LGRRV GSDI-DCEKLRQRFSLLHFM-VEVKGDLTAKQMLRALGELARR-D-HGALDCCVVVILSH GCQASHLQFPGAVYGTDGC----PVSIESIVNIFNGTGCPSLGGKPKLFFIQACGG---E QK-DPGCKVD--STSPEDRTPGSDSEPDAVPFQEGPGTF----DQP-------------- DAVSSLP-----TPSDIFV---SYSTFP--G--FVSWRDPKSGSWYVETLDGVFEQW--- -A---HSEDLQ--TLLLRVAHAVSEK-----------GVYKQIPGCFN-----FLRKKFF FKTY----------------- >G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MSVNGPGEDRTDAKT------------------ ------------------------------------------------------------ -------------------------------------------------------EQSEV SSS-ASAPEEVDA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------KPNVHSFRYS--LSFPSIGQCIIINNKNFD--RGTG-------MNQRN GTDV-DAANAMKVFGNLGYK-VKVYNDQSVAQIQHVLTSVSKQ-D-HSCSASFVCVLLSH GDG-------DLFFGTDG-----PVPLKSLTSLYRGDRCKSLVGKPKLFFIQACRG---T EL-DPGIEAD--S-------------------------------VK-------------- DETTRIP-----VEADFLY---AFSTAP--G--YYSWRNTTTGSWFMQSLCDMISKY--- -G---KELELQ--HIMVRVNHKVAVAFESVS-NSPDFNARKQIPCVVS-----MLTKEMY FSP------------------ >E_caballus_ENSECAP00000004055 -----------------------------------------------------------M NFNSCLYNIGEQLDSDELASLKFLSLDHIPQRKQEPIQDALMLFQRLQEKRL----LEES NLS-------------FLKELLFR--INRLDLLTTELDTSKEEMERELQSPGRAQ---IS AY--------------------------------R------------------------- -----------VMLFQISEDVNKLELKSF-KFLLSRELPKCRLDDDMILLDI-------- ------------------------------------------------------------ ---------------------------------------------------FI-EMEKRV MLG-ERNLDTLKKIC------------------------------------------EQV NKSLLKKINDYEELSREGRISLERSPDEFSNASLKCLQREGSLAG--------------- --------------------------------------------------------QAMS DSPGQQNS----ESQTSDKVYR--MESKPRGYCLIFNNHDFS--AARRDVPKLQNIKDRN GTDL-DAEALSMTFTELHFE-VVPYKNSTAKDICDALREYQEM-D-HKKKDCFICCILSH GDK-------GIIYGCDGQ----EASIYELTSYFTGSNCPSLAGKPKIFFIQACQG---D NY-QKGIAVE--TDS--------------ELTDAYLEMD-----SS-------------- FQKRCIP-----DEADFLL---GMATVN--N--CVSYRNPLEGTWYIQSLCQSLRER--- -C--PRGEDIL--TILTNVNFEVSSKD-----D--KKNMGKQMPQPTF-----TLRKRLV FPLN----------------- >G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------DKYRYK--MDYPCMGTCVIINNKTFD--PKTG-------LSPRN GTDV-DAAELEKTFSRLGYK-VTVANDQTADQMVDLLADVSKQ-D-HRKSASFVCALLSH GDE-------DGIYGTDG------TSLDDLTKFFKGDRCRSLVGKPKLFFIQACRG---T DT-DRGVNFD--ADS----------------------------TDG-------------- QMLQSIP-----LEADFLY---AYSTPS--G--YYSWRNTQNGSCFMQSLCEILHSF--- -S----QLELM--QIMTRVNYEVALHFESSS-DKLGYSGKKQIPCIMS-----MLTKDFY FPK------------------ >T_rubripes_ENSTRUP00000037606 ------------------------------------------------------------ ------------------------------------RSKMLHCGMREQDART----LRRQ SAV-------------LCKQLVVD--ELLIQCLQADD----------------------- ------------------------------------------------------------ -----------ILTESMAESIMAEQTSQK---RSWRLQLLLPKRGPKAFSSF-------- ------------------------------------------------------------ ---------------------------------------------------CS-ALRATD QQH-LCDLLTQTFET---------------NG--------------NG---------THV ETCVDSSVPLPTQEAV-----------------PGVCVCVCET-ESLEVSLD-ADSP--- --------------------------------------------------------INTP VLPCTPDF----YLSHFQQSYK--MASSPRGFALVISNVTFNPCAAPE-------LDPRK GGEV-DDEVLRKVFTELEYS-VTVQRDLTAQGIKTCIQNFSGRPE-HRSVDSCVVCLLSH GVE-------GAVYGIDGE----LLQLDWVFEAFDNAHCPLLQNKPKMFFIQACRG---D EM-DCGVEQI--DGPSR----------TSSPSCEQRDAG----REG-------------- RPRIKLP-----QRSDMIC---GFASLK--GQDSSHAEHQKRGSWFIQELNTALRLH--- -A---RDRHLA--DILVQVNRRIKDREGYA--PGTAHHRCKEMSEFTS-----SLCKDLF LFPKYQPQ------------- >G_gorilla_ENSGGOP00000000205 ---------------------------------------------------YILLPFEKM DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRM----LEES NLS-------------FLKELLFR--INRLDLLITYLNTRKEEMERELQTPGRAQ---IS AY--------------------------------R------------------------- -----------VMLYQISEEVSRSELRSF-KFLLQEEISKCKLDDDMXLLDI-------- ------------------------------------------------------------ ---------------------------------------------------FI-EMEKRV ILG-EGKLDILKRVC------------------------------------------AQI NKSLLKIINDYEEFSKERSSSLEGSPDEFSNG-------EELCGV--------------- --------------------------------------------------------MTIS DSPREQDS----ESQTLDKVYQ--MKSKPRGYCLIINNHNFA--KAREKVPKLHSIRDRN GTHL-DAGALTTTFEELHFE-IKPHDDCTVEQIYEILKIYQLM-D-HSNMDCFICCILSH GDK-------GIIYGTDGQ----EAPIYELTSQFTGLKCPSLAGKPKVFFIQACQG---D NY-QKGIPVE--TDS--------------EE-QPYLEMD----LSS-------------- PQTRYIP-----DEADFLL---GMATVN--N--CVSYRNPAEGTWYIQSLCQSLRER--- -C--PRGDDIL--TILTEVNYEVSNKD-----D--KKNMG-------------------- --------------------- >R_norvegicus_ENSRNOP00000017972 ------------------------------------------------------------ --------------------------------------------MEEADRQL----LRRC RVR-------------LVRELQVA--ELWDALLSRE------------------------ ------------------------------------------------------------ -----------LFTRDMIEDIQRAGSGSR-RDQARQLVIDLETRGRQALPRF-------- ------------------------------------------------------------ ---------------------------------------------------IS-CLEDTG QGS-LASFLQSSGQA------------------------------------------AKQ DPE--AVTPLDHLVPVVLGPMGLKSKEQK-VVKLDPSQPALGNLTPVVLGPEELWPTRLR PEVLT-PETPRPVDIG----------------------------------------SGRA HDVCTPGK----IERHADMAYT--LDSDPCGHCLIINNVNFC--PSSG-------LSTRI GSHV-DCEKLQHRFCWLRFM-VEVKNDLTAKKMVTALMEMAHR-D-HRALDCFVVVILSH GCQASHLQFPGAVYGTDGC----SVSIERIVNIFNGTGCPSLGGKPKLFFIQACGG---E QK-DHGFEVA--FTSSQDKAFDSDSEPDAVPYQEGPRTL----DQL-------------- DAVSSLP-----TPSDILV---SYSTFP--G--FVSWRDKKSGSWYIETLDGVLEQW--- -A---RSEDLQ--SLLLRVANAVSEK-----------GVYKQIPGCFN-----FLRKKLF FKLH----------------- >G_gallus_ENSGALP00000013591 -----------------------------------------------------------M EFSQLLFVISEALDRTELASLKFLSLEHVTVRKREDIEEPKAFFQALQEKGM----IEVG DLF-------------FLKELLYR--INRIDLLASYLGSSREEMERELQVPGRAR---VS PF--------------------------------R------------------------- -----------YLLFQLSENITKDDMKCF-KFLLGKELPKCKLSPETTMPDV-------- ------------------------------------------------------------ ---------------------------------------------------FI-EMEKKG ILK-EDNLTVLKTIC------------------------------------------GKV DKSLLKKIEDYE-----LNLLGEGEMLVTEGQRSSTGAPEDSAIWL-------------- --------------------------------------------------------ASSV APDSLGNC----DQSSQLEVYK--MTSRPRGVCLILNNHNFA--KAREAVPELRRMKDRN GTHV-DADALRKVFSNLHFT-VAEYKDCTAEEIRNIVNNYRCM-D-HNNKDCFVCCILSH GKK-------GIIYGVDGQ----EVPIQELTTSFTGQNCQSLAGKPKVFFVQACQG---D AY-QKGVTIE--TDS--------------GEQDYSLETD-----AR-------------- FQLDCIP-----SEADFLL---GMATLQ--D--YVSYRSPSQGTWYIQSLCQHLESS--- -C--PRGEDIL--TILTAVNQEVSSKI-----D--KQNAGKQMPQPSF-----TLRKKLI FPVN----------------- >O_anatinus_ENSOANP00000015596 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AGTR-RDQARQLVTDLETRGRRALSVF-------- ------------------------------------------------------------ ---------------------------------------------------IS-CLRETD QHA-LAALLSEGCQA------------------------------------------PQV TPV--DIRPVEIIRPGGQGDVCKYSKI-----HPKCYSPPLPFQSTSPLRGKEQWTGSVK PFV--------PVPST----------------------------------------TKRE QEATRPGE----KQGMAIKVYS--LKSEPCGHCLIINNVDFS--LGSG-------LSTRT GSDV-DCEKMKRRFRLLHFE-VAVERNLTAEEMVKALNKLAKK-D-HSALDCCVVVILSH GYQASHIQFPGGIHGTDGE----SISVETIVNYFNGSRCPSLGGKPKLFFIQACGG---E KK-DPGFEVN--LDSPEDHPTGSDPESDAAPFQAAPEDY----DEP-------------- DAVASLP-----TPSDILV---SYSTFP--G--FVSWRDTQSGSWYIETLDSVLDQW--- -A---HTEDLL--TLLLRVSNGVSSK-----------GKYKQIPGCFN-----FLRKRLF FNTK----------------- >C_intestinalis_ENSCINP00000024485 ------------------------------------------------------------ EFRLLLHQICEGLTGENVSMMKFLCKDAIPRSR--ELETALDFMEYFEAKGW----IQEG DLG-------------FLAEVLYR--INRHDLLKLLPGVKNRRDYEENFQAQQNNFTTYR ------------------------------------------------------------ -----------VVCFMLADELTEGDLKIL-KRLCAGKMSKANVRRSVDVLSW-------- ------------------------------------------------------------ ---------------------------------------------------LT-CMEEED LLS-EGDLDFIMSIL------------------------------------------QHL DNQKPYKLFQRVRMNDNTVTLPKNQQKSNAFQPNSHLPVASGFNSLSKQEYNHTSKLEPQ YVSMENHRAFNGGYN-----------------------------------------QYNN YQSEIKDT----STMGILDKYP----MERRGYCLIINNENFE-------------RQDRT GSGN-DTERLENLFKEFGFI-LDVRKDLDQREMEKVIQEYTKK-D-HSDKDCFVCVVMSH GLS-------GCVYGVDGL----SLSTSKISKSFRPGMCSSLTGKPKIFFFQACQG---D RT-MDGHSAP--V--------------------DDVESDG---AAS-------------- HGRQVLP-----SESDFLI---GHSTVP--G--YLSYRSRTDGSWFISTLVDSLEKY--- -H---EKEDLL--SIMINVNQEMASK------------PYKQMPMPIA-----TLRKKVF FSKQNSNSSSNQNCNTP---- >T_guttata_ENSTGUP00000010625 ------------------------------------------------------------ DFRKLLFEVSEALVTEELSALKFLSLDHVPRRKLEAIHEPKAFFEVLQEKDM----IGAG NLF-------------FLKELLYR--IHRIDLLSTPLGCSREEMERELQLPGRAQ---VS AY--------------------------------R------------------------- -----------QLLYGIAEDLTSEDVRSV-KFLLQKQLPKNKLQENASMLQV-------- ------------------------------------------------------------ ---------------------------------------------------FL-EMEIKG IIK-EDNMTTLKDIL------------------------------------------QRF RADIKKKIDAYEEKKKGLTGSAEVSLELPVSWIDSVDHIK-------------------- --------------------------------------------------------QSTL GLPGEDRS----LSFQLLEAYK--MTSRPCGVCLILNNHNFA--KAREGVLEHKHMKDRN GTDV-DAAALRNVFSKLHFR-VEEYRDLTAEEIRETVNIFQSA-D-HEDKDCFVCCILSH GKK-------GIIYGVDGQ----EVPIRELTTSFTAQNCSSLAGKPKVFFIQACQG---D AF-HKGVAIE--TDS--------------VEEDSSLERD-----AR-------------- FQLDCIP-----AEADFLL---GMATLQ--D--YVSYRSPKEGTWYIQALCQHLEYS--- -C--PRGEDVL--TILTAVNQEVSKKT-----C--ERDAKKQMPQPSF-----TLRKRLI FPVN----------------- >G_aculeatus_ENSGACP00000016983 ------------------------------------------------------------ ----------------------------------------------MSARGK----VRSQ KTA-------------IHEALCADYSLILNKVFEKG------------------------ ------------------------------------------------------------ -----------LITPREYRNLKSINKESV-EGHVIELVDKLLDKGEDTCEAF-------- ------------------------------------------------------------ ---------------------------------------------------LS-LLQTDD DIV-KTYPALRTLQL--------------------------------------------- --DDRGTLHAPVQDT--------------------------------------------- --------------------------------------------------------SVGH SDVRPPPS----KKLKKDERYE--LNSQPSGLCVIINNKNFS--------------KPRR GSDK-DAESLGEVFTWLGFR-ALMCKDQTKDQMERALNKFTALQEAPRHGDALICCILSH GRK-------GVVLGIDDQ----PLSIKQIIGTFLPPANTTLTGKPKVFLIQACQG---G QA-QHGVFEE---------------------------LQ----ADD-------------- SPSPTIP-----KEADVLV---AVATVE--D--YLAFRHITDGSWFIQSVCEQLKDG--- -C--PRGEDIT--TILQRVNWEVGKKE-----GCSAPGAGKQMPEVRF-----TLRKKLV LSPHPNCFVAK---------- >R_norvegicus_ENSRNOP00000013049 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------MTETDGFY--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----RSR----EVLDPAEQYK--MDHKRRGTALIFNHERFF--WHLA-------LPERR GTNA-DRDNLTRRFSELGFE-VKCFNDLRAEELLLKIHEVSTS-S-HVDADCFLCVFLSH GEG-------NHIYAYDA-----KIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRG---S QH-DVPVVPL--DVVDH-----------QTDKLDDNVTQ----VDA-------------- ASVYTLP-----AGADFLM---CYSVAE--G--YYSHRETVNGSWYIQDLCEMLARH--- -G---SSLEFT--ELLTLVNRKVSQRRVDFC-KDPGAIGKKQVPCFAS-----MLTKKLH FCPKPSK-------------- >D_rerio_ENSDARP00000024255 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------EQYE--MKGERRGVCLIINNYDFS--ACG--------WLNRE GTDI-DHDSLRDVFEWLGFE-ILTRRDCTGDQILQALMDLSTQ-D-HTQADCVVCCILSH GRL-------NDIIGVDGK----AVPFKELMETLSPFRCSSLYQKPKLFFIQACRG---T QN-QRAVFPQ--TFT---------------EDEDVLASD-----AG-------------- VPRDSIP-----EMADYLM---AMSTVP--W--YASYRDKSKGTWFIQSLCDNLRLL--- -V--PRGNDLL--SILTKVNADVSKKS-----D--KSGLKKQMPQPEF-----SLTRTVV FPPPGLP-------------- >M_domestica_ENSMODP00000036251 -----------------------------------------------------MEDNSKI KFNQQLLSINEKLEPEEIEALKFLCSDLISPRNLEDIESGHQLFQKFMDEDL----LNEG DYF-------------LVAELLFL--IKHHNLL-QKIGYTKEKVKKELSSKRK-----IS SY--------------------------------R------------------------- -----------VMLYNLSEEITTEDFEHI-KFIMKEHIPKTL----KTFLSL-------- ------------------------------------------------------------ ---------------------------------------------------LR-HMEKQN LLS-ENNLEILVNIC------------------------------------------KPL SINLIKRIEQYKSEKGELP------------EFELIPYHGCGVISEQVSLMTFLSLLPLF SWSRKHLPFSQQNEANNSLEEVTGL-------------------------------WAQG AEGGTLFS----DMTNEAKFYR--MDHSHRGHCIIFNNFEFQ--T----------MKRRR GSCK-DADELKSVFEWLGFT-VKIHPNTEKREMEDILQQCSTSPE-HRESDCFVCCVLTH GES-------GSVFSSDEE----KIAIRELTSYFKAHRCPGLANKPKLFFFQACQG---P DI-QESMLLE--EDA-------------KISPPIQVE----------------------- TPQRYIP-----VEADFLL---GMATVD--G--CCAIRHTIKGSWYIQALCHRLKCM--- -V--PRNEDIL--TILTEVNNDVSQLT-----D--AEGKKKQMPQPAF-----TLRKKVV FPVPPLSP------------- >T_rubripes_ENSTRUP00000024467 ------------------------------------------------------------ MDLRLLSQIDAQLDSLEVAALCFLCRDAVSPKSREGITDARGLFKKLHEKRL----LENS S---------------FLSQLLHT--IHRKDLLCLLEADSSQPEETDARPLLSEYR---- ------------------------------------------------------------ -----------VMLYKLYENLDREDLKKL-KFLLSDQLGRRQIELCKTVLDV-------- ------------------------------------------------------------ ---------------------------------------------------FT-EMEKKG LLS-NTKLDKLHSVL------------------------------------------KEV DQRLAATVHDFMQPLRGILVPRGPGTPPPAVMSMVIPVRLAVPETQSRGTEQN------- --------------------------------------------------------VSPD AESIFQSS----PPADDNEYYA--LIHNPRGLCVVFNNETFL--PGAN-------LPRRG GTME-DQKRLRSVFTKFGFT-VQVHNDFTAEAILRELKRLGKR-D-FMNEDALVVCVLSH GLK-------GCIFGTDGE----EVSLQDFTQPFVSSQAPTLAGKPKLFFIQACQG---E KL-QKGYAAW--PPRPE---------QEMAKAESQLEED----AGP-------------- VKAKVVA-----DSADFLI---GMATVE--D--YKSFRNTKNGSIYIQELCNQLQKS--- -AESPGHDHIL--DILTRVNREVSEG---------EFLNHKQMPEPKY-----TLTKKLV LKYL----------------- >D_rerio_ENSDARP00000063081 ------------------------------------------------------------ -----------------------------------------------MSKKESTQRILQH KVF-------------LIDTLSVEASFILQNVQQAK------------------------ ------------------------------------------------------------ -----------LITQRDYNNLSDVSERET---KIIKLLDKLIGRGEETCQEF-------- ------------------------------------------------------------ ---------------------------------------------------ID-LLRQDC VLE-NFPVLEGHAIF--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------A----SSVQKVSQYK--ITQNPRGICVIINNVDFT--S----------MGERR GSDE-DQNYLAKVFRWLGFE-VVAHRNKTAAEMKNILQALGRT----VDGDCFVCCVLSH GVE-------EGVCGTDGS----LVSVDEIRNPFTGVNCQKLVGKPKLFFIQACRG---Q RK-QLRVNAQ--ADGPG-------------DGESEMEVD----GD--------------- DFDITIP-----SDTDFLI---ARSTTD--G--HVSYRKPDEGSWFIQSLCRNLEKH--- -C--PLGADIL--TILLSVNNEVSIQG----------LHSKQMPVHEV-----AMRMKLI LPPVNN--------------- >A_gambiae_AGAP000830-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MSMPDVVDIRNEINKEHVRESLDRNGDEQQLVQD---------- ------------------------------------------------------------ ---------------------------------------------------VN-DALGTR KGH-DPTNHLVRARM--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PVERYACDYN--MNHKRRGLALIFNHENFD--VPQ--------LRSRA GTNV-DCENLTASLKGLDFE-VHVFKDLKLRDLQKEVERVSQM-D-HSDADCLLVTILSH GEL-------GYLYAKDC-----QYKLDTIWTYFTANHCPSLAGKPKLFFIQACQG---D QL-DGGVVLE--A-------------------KDRTETDS---SSS-------------- MLTFKIP-----MYADFMI---AYSTIP--G--FYSWRNTQKGSWFIQSLCHELNQN--- -G---RKYDLM--VLLTFVTQRVAYDFESNTPDIPMMHQQKQIPCTTS-----MLTRLVY FNQKK---------------- >H_sapiens_ENSP00000365051 ------------------------------------------------------------ ---------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRL----LRRC RLR-------------LVEELQVD--QLWDALLSRE------------------------ ------------------------------------------------------------ -----------LFRPHMIEDIQRAGSGSR-RDQARQLIIDLETRGSQALPLF-------- ------------------------------------------------------------ ---------------------------------------------------IS-CLEDTG QDM-LASFLRTNRQA------------------------------------------AKL ------------------------------------SKPTLENLTPVVL-----RPEIRK PEVLR-PETPRPVDIG----------------------------------------SGGF GDVGALES----LRGNADLAYI--LSMEPCGHCLIINNVNFC--RESG-------LRTRT GSNI-DCEKLRRRFSSLHFM-VEVKGDLTAKKMVLALLELAQQ-D-HGALDCCVVVILSH GCQASHLQFPGAVYGTDGC----PVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGG---E QK-DHGFEVA--STSPEDESPGSNPEPDATPFQEGLRTF----DQL-------------- DAISSLP-----TPSDIFV---SYSTFP--G--FVSWRDPKSGSWYVETLDDIFEQW--- -A---HSEDLQ--SLLLRVSAAFLCK-----------GEGRLLRGSVSSWGWGFGVSRAG PNQG----------------- >P_troglodytes_ENSPTRP00000056642 ------------------------------------------------------------ ---------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRL----LRRC RLR-------------LVEELQVD--QLWDALLSRE------------------------ ------------------------------------------------------------ -----------LFRPHMIEDIQRAGSGSR-RDQARQLIIDLETRGSQALPLF-------- ------------------------------------------------------------ ---------------------------------------------------IS-CLEDTG QDM-LASFLRTNRQA------------------------------------------AKL ------------------------------------SKPTLENLTPVVL-----RPEIRK PEVLR-PETPRPVDIG----------------------------------------SGGF GDVGALES----LRGNADLAYI--LSMEPCGHCLIINNVNFC--RESG-------LRTRT GSNI-DCEKLRRRFSSLHFM-VEVKGDLTAKEMVLALLELARQ-D-HGALDCCVVVILSH GCQASHLQFPGAVYGTDGC----PVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGG---E QK-DHGFEVA--STSPEDESPGSNPEPDATPFQEGLRTF----DQL-------------- DAISSLP-----TPSDIFV---SYSTFP--G--FVSWRDPKSGSWYVETLDDIFEQW--- -A---HSEDLQ--SLLLRVSAAFLCK-----------GEGRLLRGSVSSWGWGFGVSRAG PNQG----------------- >D_rerio_ENSDARP00000075650 ------------------------------------------------------------ -----------------------------------------------MDKKESVDKICEN KIF-------------LLETLSVDANFILQHVQQAK------------------------ ------------------------------------------------------------ -----------LITLRDYNNLSDFPQRET---KIINLLDKLMGKGEETCHQF-------- ------------------------------------------------------------ ---------------------------------------------------IA-LLRQDC VLE-NFPMLKDHDIF--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------D----SSVQEISPYR--IIKNPRGICVIINNEIFS--SG---------MMSRR GSDK-DREYLAKVFHWLGFE-VVEHNNKDTAEIRNILKDLGRT----VDGDCFVCCILSH GRR-------EGVCGTDGN----YLSIDEIRDPFTGVKCQKLVGKPKLFFIQGCRG---A NSLQACVKVE--ADA----------------GNSKAKVE----GD--------------- NLDITIP-----SDTDFLI---ARSTTN--G--HVSYRHVREGSWFIQSLCRNLEKH--- -C--PRGADIL--TILLYVNNEVSSQK----------SIRKQMPIYEV-----ALTRKLF LRPVNP--------------- >G_aculeatus_ENSGACP00000016969 ------------------------------------------------------------ MDRLKLSRIDEDLESSEVASLCFLCRDVLARKRLEGINNARDLFLRLEENGL----LENN S---------------FLFELLQT--IRRTDLLNLLESDSSPPEEADANPILSDYR---- ------------------------------------------------------------ -----------VMLYRVDQDITRENLSMM-KFLLSSQLGKRQMEMCNTALDV-------- ------------------------------------------------------------ ---------------------------------------------------FA-EMEKTG SLS-PTSLHEVHAAV------------------------------------------KQF DQQLALTIQRYIDN-------RGTATPRPHRPIHPQPVDVSISETQSNCSSDEGMN---- --------------------------------------------------------ICSD AEPNTKPS----SPDDHTEYYA--LIHKPRGLCVVINNEDFL--GTQ--------MKNRK GTQEDDTEALCSLFSRLGFT-MLVHNNLTAGAMKQELQKLGAR-N-FVNDDALVVCVLSH GEM-------ECVFGTDEQ----RVNITDLTRPFTSEGAPTLAGKPKLFFIQACQG---T RY-QGGSLPH--PSLPG---------QEEGVPQSPLEED----AGP-------------- IKGETVP-----WEADFLL---GMATVP--Q--CKSFRSTTTGSIYIQEVCTQLKKS--- -AESSANDDIL--TVLTRVNREVSKG---------KYLNSKQMPQPKY-----TLTKKLV LKYV----------------- >H_sapiens_ENSP00000286186 ------------------------------------------MKSQGQHWYSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDL----LSEE DPF-------------FLAELLYI--IRQKKLL-QHLNCTKEEVERLLPTRQR-----VS LF--------------------------------R------------------------- -----------NLLYELSEGIDSENLKDM-IFLLKDSLPKTE----MTSLSF-------- ------------------------------------------------------------ ---------------------------------------------------LA-FLEKQG KID-EDNLTCLEDLC------------------------------------------KTV VPKLLRNIEKYKREKAIQIVTP-----PVDKEAES-YQGEEELVSQTDVKTFLEALPQ-E SWQN-KHAGSNGNRATNGAPSLVSRG------------------------------MQGA SANTLNSE----TSTKRAAVYR--MNRNHRGLCVIVNNHSFT--S----------LKDRQ GTHK-DAEILSHVFQWLGFT-VHIHNNVTKVEMEMVLQKQKCNPA-HADGDCFVFCILTH GRF-------GAVYSSDEA----LIPIREIMSHFTALQCPRLAEKPKLFFIQACQG---E EI-QPSVSIE--ADA--------------LNPEQAPT----------------------- SLQDSIP-----AEADFLL---GLATVP--G--YVSFRHVEEGSWYIQSLCNHLKKL--- -V--PRHEDIL--SILTAVNDDVSRRV-----D--KQGTKKQMPQPAF-----TLRKKLV FPVPLDALSL----------- >M_mulatta_ENSMMUP00000040583 ------------------------------------------------------------ --------------------------------------------MDEADRRL----LRRC RLR-------------LVEELQVD--QLWDALLSRE------------------------ ------------------------------------------------------------ -----------LFKPHMIEDIQRAGSGSR-RDQARQLITDLETRGSQALPSF-------- ------------------------------------------------------------ ---------------------------------------------------IS-CLVDTG QDM-LASFLRTNRQA------------------------------------------VKL ------------------------------------SKPTLENLTPVVL-----RPEIRK PEVLR-PETPRPVDIG----------------------------------------SGGC GDVGAPES----LRGNADLAYV--LSMEPCGHCLIINNVNFC--RESG-------LSTRT GSSI-DCEKLQRRFSLLHFM-VEVKHDLTAKEMVLALLELARR-D-HSALDCCVVVILSH GCQASHLQFPGAVYGTDGC----PVSVERIVNIFNGTSCPSLGGKPKLFFIQACGG---E QK-DHGFEVA--STSPEDESSGSNPEPDATPFQEDLRTF----DQL-------------- DAVSSLP-----TPSDIFV---SYSTFP--G--FVSLRDPKSGSWYIETLDNIFEQW--- -A---HSEDLQ--SLLLRVADAVSVK-----------GIYKQMPGCFN-----FLRKKLF FKTS----------------- >G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MSPRN GTDV-DAADAFRTFSKLGYK-VTVANDQTVDQMIQLLVKVSKQ-D-HSNSASFVCVLLSH GDE-------GVIYGTDG-----FEKLDDLTKFFKGDRCRSLVGKPKLFFIQACRG---T EL-DEGSQIE--ADS----------------------------VGG-------------- QTSDRIP-----VEADFLY---AYSTAP--G--YYAWRNTQNGSWFMQSLCEMLRRF--- -S---GQLELM--QIMTRLNHRVALHFESSS-DTPGYSGKKQIPCIVS-----MLTKDFY FPK------------------ >G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MSDTTGDGRGGRVASP------------------------------- ------------------------------------------------------------ ----------------------------------------------------N-KAATDR AAC-TENLTETDALI--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------R----SSLDPAEEYK--MDNKRRGLALIFNQERFF--WRLG-------LNDRH GTNA-DRYNLERRLSNLNFD-VRAYDNLKQEEVLNKINEAAEE-N-HSDSDCFLLVFLSH GEN-------DQVYTYDG-----KISVQDITSLFKGDKCKSLVGKPKIFILQACRG---D KH-DDPVTAC--DAVDS--------------ELKTNEVV----VDA-------------- SVLHTLP-----AGADFIM---CYSVAE--G--YYSHRETINGSWYIQDLCELLQRY--- -G---DSHEFT--EVLTLVNRKVSMRSVGNS-SDRSAIGKKQVPCFAS-----MLTKKLY FRPKQ---------------- >R_norvegicus_ENSRNOP00000016613 -----------------------------------------------------------M DFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQESINDVLVLFQRLQEEGM----LEED NLS-------------FLKELLFH--ISRRDLLSRVLKSSPEEMVRELQVLGKAQ---VS AY--------------------------------R------------------------- -----------VMLFKLSEDMDKEDLKSF-KFLLITEIPKCKLQDNSSLLDI-------- ------------------------------------------------------------ ---------------------------------------------------FV-EMEKRT ILA-ENNLVTLKSIC------------------------------------------FRV NRSLLGRIDDYERSSTERRMSTEG-----GEELPVSVLDEVTIKM--------------- --------------------------------------------------------QDMW DSPGEQES----ESLNSDNVYQ--MKSKPRGYCLIFNNNNFS--KAREDIPKLSNMRDRK GTNY-DEEALSKTFKELHFE-IVSFSDCTASQIHEVLVSYQSK-D-HKGKDCFICCILSH GDK-------GIVYGTDGK----EASIYELTSYFTGSKCPSLAGKPKIFFIQACQG---N NF-QKAVPVPDETGL--------------EQ-EHVLEED-----SS-------------- SYKNYIP-----DEADFLL---GMATVK--N--CVSYRDPTRGTWYIQSLCQSLRER--- -C--PRGEDIL--SILTGVNYDVSNKD-----N--PRNMGKQMPQPIF-----TLRKKLF FPPN----------------- >T_rubripes_ENSTRUP00000044662 ---------------------------------------------------------CNM DFQARLLKVGNDLRKDEVRALVFLCSDILGCNP-AAVQSAGDLFSRLSDQDH----LSEE QPH-------------LLVELLGI--IQRTKLL------------RDHNLPRTGAQDLIS PY--------------------------------SCKSR--------------------- -----------KLLYSLSEELTADDLKDI-KFLLNNKLPRGKLEE-VTTLEV-------- ------------------------------------------------------------ ---------------------------------------------------FM-ELEHRA LIS-DTDLGFLESII------------------------------------------QPV CPVLLEKINQFNAQNCKMHLILHIFDSYLNQIQLNTQLKALWLIKKFDSFLVSFSSNESW IGGSGNRPTNRCPLLTAASLLEQS--------------------------------CSFN TLQVGCPD----VSVQGVETYL--MTAAKRGRCLIINNCNFR--VSR--------LKKRE GTMV-DEASLDKVLKWLGFE-VEIQRDCTSKKMSSLIQELAKT-S-QRDWDCVMCCVLSH GLE-------GGVYGVDGG----TVEIRKLMEPFSGTNCPSLAGKPKIFFIQACQG---S RQ-QDIVYTD--AGT---------------PGHGYVDNN-----AV-------------- QAKECIP-----SHADFLL---GMATVP--S--FVSFRDGTHGTWYIQSLCQNLADM--- -V--PRGCDLI--SILTKVNADVSKKV-----AWIDSGHKTQMPQPAF-----TLTKKIV FPAPNTPHPV----------- >M_musculus_ENSMUSP00000027189 -----------------------------------------------------------M DFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGM----LEEG NLS-------------FLKELLFH--ISRWDLLVNFLDCNREEMVRELRDPDNAQ---IS PY--------------------------------R------------------------- -----------VMLFKLSEEVSELELRSF-KFLLNNEIPKCKLEDDLSLLEI-------- ------------------------------------------------------------ ---------------------------------------------------FV-EMEKRT MLA-ENNLETLKSIC------------------------------------------DQV NKSLLGKIEDYERSSTERRMSLEG-----REELPPSVLDEMSLKM--------------- --------------------------------------------------------AELC DSPREQDS----ESRTSDKVYQ--MKNKPRGYCLIINNHDFS--KAREDITQLRKMKDRK GTDC-DKEALSKTFKELHFE-IVSYDDCTANEIHEILEGYQSA-D-HKNKDCFICCILSH GDK-------GVVYGTDGK----EASIYDLTSYFTGSKCPSLSGKPKIFFIQACQG---S NF-QKGVPDE--AGF--------------EQQNHTLEVD-----SS-------------- SHKNYIP-----DEADFLL---GMATVK--N--CVSYRDPVNGTWYIQSLCQSLRER--- -C--PQGDDIL--SILTGVNYDVSNKD-----D--RRNKGKQMPQPTF-----TLRKKLF FPP------------------ >E_caballus_ENSECAP00000021726 ------------------------------------------MTSQGQNLNSSSDDNCTM DFRQKLLFIDSHLGDQDVERLRFLCRDCVSHKKLEKSSSALEIFNHLLAEDL----LREE DSF-------------FLAELLYI--IKQKSLL-CHLCYTKEQVESLLPARRR-----VS LF--------------------------------R------------------------- -----------NLLYELSEGMDSDNLNSM-MFLLKDSIPKTQ----MTSLSL-------- ------------------------------------------------------------ ---------------------------------------------------LA-HLEKQA RID-EDNLTLLEMLC------------------------------------------KNV VPNLMRKIEKYKREKAAQVVTA-----PVDKETESLHHGEEELFSRSDIKKFSRALPQ-- ---PWEHTHAGLGSLPLGN-SRVSKG------------------------------WSSA LASGIGSI----SSSKETPLYR--MDRTHRGHCVVVNNHTFT--S----------LADRP GTDK-DAECLKSVFQWLGFS-VHRYDNVTKEGLEKVLQEYRNHPG-HASGDCFVFCVLTH GKF-------GAVYSSDGI----LIPIREIMSHFTAQRCPALAHKPKLFFIQACQG---E EV-QPSVSIE--ADA--------------VNPENVTP----------------------- SLEDSVP-----VEADFLL---GLATVP--G--YVSFRHVKEGSWYIQSLYNNLKDL--- -V--PRREDIL--SILTAVNDDVSRQV-----D--IYGKKKQMPQPAF-----TLRKKLV FPVP----------------- >B_taurus_ENSBTAP00000003205 ------------------------------------------------------------ --------------------------------------------MNEADRLL----LRRY RVR-------------LVGELQVA--SLWDALLSRE------------------------ ------------------------------------------------------------ -----------LFTPDMIEDIQRAGSGSR-RDQARQLILDLETRGSQALPLF-------- ------------------------------------------------------------ ---------------------------------------------------IS-CLEDTG QDT-LASLLKTSRQA------------------------------------------AKQ ------------------------------------SKPSQGKLAPVVLGPEELWPAKLR PEVLR-PEVPRAVDAG----------------------------------------SGGF TDVCPQDR----AKGNADLAYV--LNADPCGHCLIINNVNFC--RESG-------LRART GSNI-DCERMRQRFHLLQFV-VEVKCDLTAKQMVQALMQLARQ-D-HSALDCCVVVILSH GCQASHLQFPGAVYGTDGC----PVSVERIVNTFNGTGCPSLRGKPKLFFIQACGG---E QK-DHGFEVE--STSPEDKTPSSDPEADATPFQEGPRSI----DEP-------------- DAVSSLP-----TPSDILV---SYSTFP--G--FVSWRDPKSGSWYIETLDSIFEQW--- -A---HCEDLQ--TLLLRVANAVSVK-----------GIYKQMPGCFN-----FLRKKLF FKT------------------ >O_anatinus_ENSOANP00000006351 -----------------------------------------------------------M DFHRLLFSIGEELAADDLEALKFLCLDLIPRKKQENIQDALGLFRLLQEKGM----LEEG KLF-------------FLKELLFR--IHRIDLLTSHLRTSQEDVARELEEPGRAQ---VS AYS-------------------------------R------------------------- -----------VLLFTLSDNVTREELKSI-TFFLSNDLPRSRLDNKQTLMGI-------- ------------------------------------------------------------ ---------------------------------------------------FI-EMEKKG ILG-ESNLDMLKKIC------------------------------------------DKI DKTLLGKIDHYEERRADCTLHSSEHLTVLDRDMYIIPIIYDEIILL-------------- --------------------------------------------------------PTES SFRGHSGG----EAEQNGDFYK--MNSNPRGYCLIINNYNFQ--QARAEVPKLKKMKNRD GTDK-DAEALSQIFKALAFS-PVVFEDQTAEQILETLQSYQRM-D-HSAQDCFVCCILSH GDR-------GVVYGTDGQ----QASIRSLTSYFTGSRCPTLAGKPKLFFIQACQG---D AY-HLAVALE--TDNGT---------DKGTAAASPAEPD-----AV-------------- FHERCIP-----DEADFLL---GMATVS--N--CVSYRIPSKGTWYIQSLCHHLRNL--- -C--PLGADIL--TILTKVNFEVSQKI-----D--LTNRGKQMPQPMF-----TLRKKLV LPLL----------------- >T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GSDAEL------------------------------- ------------------------------------------------------------ ----------------------------------------------------G-KTATDS SAC-TGDLMETDAIS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----GSI----GFLDPAEEYK--MDNKRRGLALIFNQERFF--WRLG-------LRDRH GTNA-DSYNLQRRLKELNFE-VKVFDNHTQAQVLEIITSAAKD-D-HSNVDCFLVVFLSH GEN-------DHIYTFDD-----KINVQDITSLFKGDKCKSLVGKPKIFILQACRG---D KH-DEPATAAAFDDVDS--------------ELKKNEVE----VDA-------------- SAVYTLP-----AGADFIM---CYSVAE--G--YYSHRETVNGSWYIQDLCDLLRKY--- -G---DSLEFT--ELLTLVNRKVSMRSVGYC-SDPNAIGKKQVPCFAS-----MLTKKLY FRPKK---------------- >C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MSLKSAADVLMSGVPTPHTNENNNVGQSEVD------------------ ------------------------------------------------------------ ------------------------------------------------------ALGSGE TPR-IYSLPDVTK----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------MASSEVECYQ--MDRESRGLALIINNENFH--HATR-------MNKRS GTDV-DARNLSRIFKKLGFD-VQVYKDLSCISMLEVINEVSTM-D-HTGNDCCFVAFLSH GDD-------GCVYGTDG-----IVQIKKIVDQFRGDVCPSLAGKPKIFLFQACRG---T LH-ETSVQLS--VDV--------------VDGEDQPCVE----VDA-------------- APVPTLP-----SGSDYLF---CYSVAE--G--YYSHRDTLYGSWFIQDFTDVMEQLVLN KGKQQDKVDFI--DVLTVVNRKVSARRVERS-YSQQALGKKQMPCYLS-----MLTKKLY LTPKK---------------- >C_intestinalis_ENSCINP00000025743 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------KYK--MNHKERGCFMIFNQEVYD--AKTSLN-----LGERI GSST-DARNLASAAAYLGFEYIQVFNNLTRSKILKWLKDVAAA-S-HESYDCFGCAILTH GDKN------NELYARDA-----SMNITDFTNPFTADKCPTLAGKPKLFFVQACRG---H KR-DTAVPFT--L---------------------NVAST----IEK-------------- TELKLIP-----CQADFLI---ASSTPE--G--YSSWRNKANGSWFIQALYLCIQRY--- -----PSLEIM--QIMTRVNRMVALHFENT--NTESPDIYKQIPSICT-----RLTGELY FHKPGST-------------- >P_pygmaeus_ENSPPYP00000014602 ------------------------------------------MKSQGQHWCSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCVGLVPNKKLEKSSSASDVFEHLLAEDL----LSEE DPF-------------FLAELLYI--IRQKKLL-QHLSYTKEEVEGLLPTRQR-----VS LF--------------------------------R------------------------- -----------NLLYELSEGIDSENLKDM-IFLLKDSLPKTE----MTSLSF-------- ------------------------------------------------------------ ---------------------------------------------------PA-FLEKQG KID-EDNLTCLEDL-------------------------------------------KTV VPKLLRNIEKYKREKAVQIVTP-----PIDKEAES-YQGEEELVSQTDVKTFLEALPQEE SWQN-KHAGSNGNRATNGAPSLVSRG------------------------------MQGA SANTLNSE----TGTKGRKGYR--MNRNHRGLC-LLNNHSFT--S----------LKDRR GTHK-DAEILSHVFQWLGFT-VHIHNNVTKGEMEEVLQEQKCNPA-HADGDCFVFCILTH GKF-------GAVYSSDEA----LIPIREIMSHFTALQCPRLAEKPKLFFIQACQG---E EI-QPSVSIE--ADA--------------LNPEQPPT----------------------- SLQDSIP-----AEADFLL---GLATVP--G--YVSFRHVEEGSWYIQSLCNHLKKL--- -V--PRHEDIL--SILTAVNDDVSRRV-----D--KQGTKKQMPQPAF-----TLRKKLV FPVPLDALSL----------- >O_cuniculus_ENSOCUP00000006164 -------------------------------ALVESGTVGDWVTVPGEGNGYXXXXXXXX XXXXXXXXXXEQLDSELL--LKF-ELDYIPQRKQEPIQDALMLFQRLQEKRM----LEEN NLA-------------FLKELLFR--IHRLDLLSTLLGTSKEEMVTELQIPGRAH---IS AY--------------------------------X------------------------- -----------XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX-------- ------------------------------------------------------------ ---------------------------------------------------XX-XXXXXX XXX-XXXXXXXXXXX------------------------------------------XXX XXXXXXXXXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXX--------------- --------------------------------------------------------XXXX XXXXXXXX----XXXTSEEVYQ--MKSKPRGYCLIVNNYDFS--IARREMPRHRNMKDRK GTEV-DAEALSNTFTDLHFE-VVHYNDCTAKQICDILQSYQSM-D-HKDRDCFVCCILSH GDK-------GIIYGTDGQ----EACIYDLISYFTGSKCSSLAGKLKVFFIQACQG---D KY-QQAVPAI---DS--------------EQ-QSYLD-------SS-------------- FPKRYVP-----DEADFLL---GMATVN--N--CVSYRNLFEGTWYIQSLCQSLRER--- -C--PQGEDIL--SILTKVNYKVSIKE--------AGEKKKQMPQPTF-----TLTKRLL FPLD----------------- >D_melanogaster_FBpp0071971 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MTDECVTRNYGVGIRSPNGSENRGSFIMADNTDAKGCTPES-------- ------------------------------------------------------------ ---------------------------------------------------LV-VGGATA ASP-LPANKFVARM---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PVERYASEYN--MSHKHRGVALIFNHEFFD--IPS--------LKSRT GTNV-DAQELKKAFENLGFA-VSVHKDCKLRDILKHVGKAAEL-D-HTDNDCLAVAILSH GEH-------GYLYAKDT-----QYKLDNIWHYFTATFCPSLAGKPKLFFIQACQG---D RL-DGGITLE--K--------------------GVTETD----GES-------------- STSYKIP-----IHADFLF---SYSTIP--G--YFSWRNINNGSWYMQSLIRELNAN--- -G---KKYDLL--TLLTFVNQRVALDFESNVPATPMMDRQKQIPCLTS-----MLTRILR FGDKPNGNKAG---------- >X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MASAKQQSSPSAGQIEKD------------------------------- ------------------------------------------------------------ ----------------------------------------------------S-SSASQN KEQ-KANVAETDGWT--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----SRT----LELDPSAEYK--MTHKRRGLALIFNHEDFY--WQLR-------LGSRR GTNT-DSMNLNRILTDLGFD-VQNYYNLRTLDILEKIQEASTA-D-HSNADCFLCVFLSH GED-------RHIYSYDS-----LIDIQELTNSFKGDKCESLVGKPKIFIFQACRG---E KH-DNPVLPT--DETDS--------------VTLTNITE----VDA-------------- ASLYTLP-----AGADFIM---CYSVAE--G--YYSHRETVNGSWYIQDLCEVLKAH--- -A---ASLEFT--EILTLVNRKVSQRSVAFC-NDPKAIGKKQIPCFSS-----MLTKKLF LKPKSN--------------- >X_tropicalis_ENSXETP00000008971 -----------------------------------------------------------M DFNSMLLSIDDGLGREDIEALKFLCRDVLRKNKLLSVRSGQELFQQLMTEDL----INED NFF-------------LLKELLYI--INHHSLL-RNLGTNKEKVQKALPRQGR-----IS PY--------------------------------R------------------------- -----------QMLYQLSENIAGDDEKRV-YFLLPL---QKKHKENKTFLEV-------- ------------------------------------------------------------ ---------------------------------------------------LC-QLEREN SIT-EDDVELLEDIF------------------------------------------KKV APDLLKIIEKYKERGDKLHQTENHLIDPSAPPEDEHELINPPLSIQVSSKDSELWDKGTE SLIEHTGMIHEEAEKEDDKSGNINH-------------------------------QLSD LRLNSEMT----PQANKEEFYD--MNHKHRGYCLIIDNSVFM--K----------GNRRE GSDK-DAGALSDVFSWLGLE-VDIFENLMSEQIRDCLKRFKSR-D-HSERDCFVCCILTH GES-------GTVMGSDDK----EVSIREIMSYFTAISCTSLVLKPKLFFIQACQG---K FT-HPSSKVE--ADA--------------------IVPE----ENK-------------- KYVVNVP-----KDADFLL---GMSTVD--G--YAAYRHTREGSWYIQALCKNLVEL--- -V--PRGEDIL--AILTKVNKDVSLKE-----G--QQGILKQMPQPSY-----TLLKKLR FPVPDVPFRPKTC---QENSP >G_gallus_ENSGALP00000013571 ---------------------------------------------------------MSS DFRKLLFDISEALATEELAALKFLSLEHVPVRKQEDTEEPKAFFEVLKEKGM----IEVE DLF-------------FLKELLYR--INRIDLLASHLGSSREEMERELQVPGKAK---VS AY--------------------------------R------------------------- -----------QLLYGIAEDLTPDDVRSI-KFLLQEKLPKNKLQDNASMLKV-------- ------------------------------------------------------------ ---------------------------------------------------LV-EMERNG IIK-EDDLTMLKSIL------------------------------------------KAF RADLKKKIDNYEEKTKGWPWKSSCFPNKTQALSISENLAVSSLIDNKESQESQ------- --------------------------------------------------------SEWY SAGIFPPH----VQILLVESYK--MENNPHGYCVILNNYRFK--NPN---------ETRK GTVE-DGKALKRVFKWLQFD-TIEYMDLEAKQIFAKVNEYSKK-D-HSNMDCFVCFILSH GEK-------GKIKGVDNE----LVNIKDLLSCFSGSNCPSLAGKPKLFFIQACQG---S VG-HPAVTVK--EDC-----------------SGHLETD------A-------------- IPALSIP-----DQADVLV---GMATVE--D--FECYRSIETGSVYIQCLCDKMELL--- -C--PLRKDLI--TILTEVNKEVGRRV---------LNGWKQMPKITS-----TLRKQFI FQIPQCQ-------------- >T_nigroviridis_ENSTNIP00000010874 ------------------------------------------------------------ ---------------------------------------MLQCGMVERDAQA----LKKQ SAV-------------LFKQLVVD--ELLIQFLQADD----------------------- ------------------------------------------------------------ -----------ILTDSMAESILAEQTSHK---RCWKLLHLLPKRGPKAFSSF-------- ------------------------------------------------------------ ---------------------------------------------------CS-ALRETD QKH-LCDLLARTSQE---------------NG--------------NG---------THL ETCVDSSVPLPTQEAV-----------------PAKRARTQ---ESMEISLD-ADSP--- --------------------------------------------------------INTP VCPCTPDF----YHSHSQQSYK--MTSSPRGLALVISNVRFSPFAAPD-------LDPRQ GGEV-DDEVLRKVFTELDYL-VTVQRDLTAQGIKTCIENFSRRPE-HQSVDSCVVCLLSH GVE-------GAVYGVDGK----LLQLDWVFTAFDNAHCPLLQNKPKMFFIQACRGGSVD EM-DCGVEQI--DGPSR----------TGSPSCEQRDAG----REGE------------- RPRIKLP-----QRSDMILRSPRSKSPS--G--TAAMRNTKRGSWFIQELNKALRLH--- -A---RDKHLCRHSGAGKVNSRIKEREGHA--PGTAHHRCKEMSEYTS-----SLCKDLF LFPKYQPQY------------ >G_gallus_ENSGALP00000001569 ------------------------------------------------------------ -----------------------------------------------------LLRVRAD FVS-------------RVRKAVVS--NLLDELLAHR------------------------ ------------------------------------------------------------ -----------VLNQAEVDEVQEGNPVTT--DKARSLIDTVRLKGPRASAIF-------- ------------------------------------------------------------ ---------------------------------------------------ID-SLRKHD CNL-AEQLRLCAHAE--------------------------------------------- --------------------------------PPGAPLAAPSTVGFSDPPVSSQDLQWIQ Q-------------------------------------------------------CPLS EYQRIKEA----EGDQIYDIYQ--PRERRTRRALLICNTKFK--H----------LRQRD GAEV-DVKEMTKLLEGLGYN-VECHEDKTSQEMTTVMKKFADHKD-HLTSDSTFLVFMSH GMS-------TGICGTKSNGTTDILSFNTIYENFNNKHCRALMGKPKVVIIQCCRG---D NI--GSVQIR--DSIDP--------EMPTSTSDGWRCVE----LQG-------------- SKTREAH-----LESDFAT---LYSSTP--D--TVSWRSPTEGSVFIQRLVEQFRNH--- -A---FNSDLQ--EMFRKVQRSFE-------------NFPRQLPTQERT----TMLKKFY LFPGL----------------