Name | Synonyms | Species | Family | Process | Pathway | Refs | Description | Comments |
DCT-1 |
|
Worm |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
|
9824163 |
dct-1 encodes a protein with similarity to the mammalian BNIP3 proteins that interact with Bcl-2 and the Adenovirus E1B 19kDa protein and that have been shown to have pro-apoptotic activity. loss of dct-1 activity via RNAi in daf-2 mutants and in gld-1. daf-2 doubly mutant animals indicates that dct-1 can function to regulate both lifespan and tumor cell proliferation. when expressed in mammalian cells, DCT-1 can: 1) induce delayed apoptosis and increase apoptosis when coexpressed with CED-3 (perhaps by increasing proteolyic processing of CED-3), 2) physically interact with CED-9 or the CED-3 prodomain when coexpressed, and 3) physically interact with both CED-9 and CED-3 when all three are coexpressed. chromatin immunoprecipitation experiments have demonstrated that the dct-1 promoter is bound in vivo by the forkhead transcription factor DAF-16. expression of DCT-1 in mammalian cells suggests that, like its mammalian orthologs, DCT-1 localizes to mitochondria via a predicted C-terminal transmembrane domain. [Source: WormBase] |
|
CED-4 |
|
Worm |
CARD-CONTAINING PROTEIN;CARD ADAPTER PROTEIN |
APOPTOSIS |
|
9109415 |
ced-4 encodes a novel protein. along with CED-3, CED-4 is required for the initiation of programmed cell death. accordingly, genetic analyses indicate that ced-3 and ced-4 function upstream of ced-1, ced-2, and nuc-1 in the programmed cell death pathway. in yeast two-hybrid experiments, and upon coexpression in mammalian cells, CED-4 interacts with CED-9, an anti-apoptotic BCL-2 homolog. coexpression of CED-4 and CED-9 results in redistribution of CED-4 from the cytosol to organellar membranes, suggesting that CED-9 may negatively regulate CED-4 activity by sequestering CED-4 to intracellular membranes. [Source: WormBase] |
|
CED-3 |
|
Worm |
CASPASE |
APOPTOSIS |
|
8654923 |
The ced-3 gene encodes a protease required for apoptosis. [Source: WormBase] |
|
TNFRSF21 |
TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21, DR6, IM:6795346, WU:FA55E01, WU:FB02E11, WU:FC29A09, WU:FI27H08 |
Zebrafish |
DEATH RECEPTOR |
UNDEFINED |
EXTRINSIC PATHWAY |
16888647 |
tumor necrosis factor receptor superfamily, member 21 [Source:RefSeq_peptide;Acc:NP_001036153] |
Expression detected in regions of the developing zebrafish central nervous system [16888647] . |
TNFSF10L |
TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY MEMBER 10 LIKE, TRAIL-LIKE, FC12F06, WU:FC12F06, DL1A, DR_TRAIL-LIKE V2 |
Zebrafish |
DEATH LIGAND |
APOPTOSIS |
EXTRINSIC PATHWAY |
16888647,17548633 |
tumor necrosis factor (ligand) superfamily, member 10 like [Source:RefSeq_peptide;Acc:NP_571918] |
Ectopic expression of Tnfsf10l in zebrafish embryos induces apoptosis in the notochord [16888647] . Tnfsf10l directly associates with the zebrafish death receptor Tnfrsfa [16888647] . Tnfsf10l-induced apoptosis can be blocked by ectopic expression of zebrafish Cflar or by knockdown of endogenous Tnfrsfa or FADD [16888647] . Zebrafish Tnfsf10l is more structurally related to Apo2L-like (a second copy of Apo2L/TRAIL found in avian species but not mammals) than to mammalian Apo2L/TRAIL due to additional cysteine residues in its extracellular domain 16888647 . |
HDR |
HEMATOPOIETIC DEATH RECEPTOR, ZGC:103531, ZH-DR, MGC103531 |
Zebrafish |
DEATH RECEPTOR |
APOPTOSIS |
EXTRINSIC PATHWAY |
16888647,10934476,16413388 |
hematopoietic death receptor [Source:RefSeq_peptide;Acc:NP_919372] |
Ectopic expression of HDR in zebrafish embryos and human cell lines induces apoptosis [16888647]. HDR directly associates with the zebrafish Apo2L/TRAIL orthologs tnfsf10l and tnfsf10l3 [16888647]. Inhibition of HDR in zebrafish embryos and adult fish leads to an accumulation of red blood cells [10934476],[16413388]. |
TNFRSFA |
TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER A, OTR, WU:FC27C09, TNF, OVARIAN TNF RECEPTOR |
Zebrafish |
DEATH RECEPTOR |
APOPTOSIS |
EXTRINSIC PATHWAY |
16888647,11399482 |
tumor necrosis factor receptor superfamily, member a [Source:RefSeq_peptide;Acc:NP_571915] |
Ectopic expression of Tnfrsfa in zebrafish embryos and human cell lines induces apoptosis [16888647] . Tnfrsfa directly associates with the zebrafish Apo2L/TRAIL orthologs Tnfsf10l and Tnfsf10l2 [16888647] . |
MCL1B |
MYELOID CELL LEUKEMIA SEQUENCE 1B, ZGC:109763 |
Zebrafish |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
16888646 |
myeloid cell leukemia sequence 1b [Source:RefSeq_peptide;Acc:NP_919375] |
Ectopic expression of Mcl1b in zebrafish embryos inhibits apoptosis induced by several pro-apoptotic Bcl2 family members [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ] and gamma-irradiation [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ]. Simultaneous knockdown of both Mcl1a and Mcl1b in zebrafish embryos using antisense morpholino oligonucleotides significantly decreases viability and increases sensitivity to apoptosis induced by the Apo2L/TRAIL ortholog Tnfsf10l3 [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ]. |
BCL2L |
ZFBLP1, BCL-XL, CB1021, BCL2-LIKE |
Zebrafish |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
16888647,11406282,16888646 |
bcl2-like [Source:RefSeq_peptide;Acc:NP_571882] |
Ectopic expression of Bcl2l in zebrafish embryos inhibits apoptosis induced by multiple stimuli including death receptor signaling [16888647], ectopic expression of several pro-apoptotic Bcl2 family members [16888646], and gamma-irradiation [16888646]. |
BOKB |
BCL2-RELATED OVARIAN KILLER B, ZBOK2, ZGC:64041 |
Zebrafish |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
UNDEFINED |
INTRINSIC PATHWAY |
16888646 |
Bcl-2-related ovarian killer protein homolog B (zBok2). [Source:UniProtKB/Swiss-Prot;Acc:Q7T381] |
|
TNFA |
TUMOR NECROSIS FACTOR A (TNF SUPERFAMILY MEMBER 2), TNF-ALPHA, TNFA, TNF1 |
Zebrafish |
DEATH LIGAND |
UNDEFINED |
EXTRINSIC PATHWAY |
11399482,16888647 |
tumor necrosis factor, alpha [Source:RefSeq_peptide;Acc:NP_998024] |
Tnfa binds selectively to Tnfrsf1a, the zebrafish ortholog of TNFR1A [16888647] . |
MCL1A |
MYELOID CELL LEUKEMIA SEQUENCE 1A, ZFMLP1, WU:FB72F02, FB70A08, ZGC:109835, WU:FB70A08, ZFMCL-1A, FB72F02 |
Zebrafish |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
16888646,11118352 |
myeloid cell leukemia sequence 1a [Source:RefSeq_peptide;Acc:NP_571674] |
Ectopic expression of Mcl1a in zebrafish embryos inhibits apoptosis induced by several pro-apoptotic Bcl2 family members [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ] and gamma-irradiation [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ]. Simultaneous knockdown of both Mcl1a and Mcl1b in zebrafish embryos using antisense morpholino oligonucleotides significantly decreases viability and increases sensitivity to apoptosis induced by the Apo2L/TRAIL ortholog Tnfsf10l3 [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ]. |
FASLG |
FAS LIGAND (TNF SUPERFAMILY, MEMBER 6), FASL, ZGC:162027 |
Zebrafish |
DEATH LIGAND |
UNDEFINED |
EXTRINSIC PATHWAY |
16888647 |
Fas ligand (TNF superfamily, member 6) [Source:RefSeq_peptide;Acc:NP_001036166] |
|
TNFB |
TUMOR NECROSIS FACTOR B (TNF SUPERFAMILY, MEMBER 2), TNF-ALPHA, TNF , TNF2, TNF-A_V2, TNFA-LIKE |
Zebrafish |
DEATH LIGAND |
UNDEFINED |
EXTRINSIC PATHWAY |
11399482,16888647 |
tumor necrosis factor (TNF superfamily, member 2) [Source:RefSeq_peptide;Acc:NP_001019618] |
|
CASP3A |
CASP3; MGC100890; ZGC:100890; CASP3A |
Zebrafish |
CASPASE |
APOPTOSIS |
,UNDEFINED |
11695990,16888647 |
caspase 3, apoptosis-related cysteine protease [Source:RefSeq_peptide;Acc:NP_571952] |
Ectopic expression of Casp3a in zebrafish embryos and fish fathead minnow tailbud cells induces apoptosis 11695990 . Activated Caspase-3 is detected in zebrafish embryos following gamma-irradiation and ectopic expression of numerous pro-apoptotic genes 16888646 . Recombinant Casp3a shows strong activity toward the mammalian Caspase-3 and -7 substrate Ac-DEVD-MCA and weak activity toward Caspase-1, -6, -8, and -9 substrates [11695990] . Structural information for zebrafish Casp3a has been obtained by X-ray crystallography [16842121] . |
BAXA |
BAXA, BCL2-ASSOCIATED X PROTEIN A, WU:FJ16E01, ZBAX1, BAX, FJ16E01, WU:FC50B10 |
Zebrafish |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
16888646,15630097 |
bcl2-associated X protein, a [Source:RefSeq_peptide;Acc:NP_571637] |
Overexpression of Baxa RNA in early stage zebrafish embryos induces Caspase-3 activation and apoptosis [16888646]. Knockdown of Baxa using antisense morpholino oligonucleotides protects zebrafish embryos from apoptosis in response to gamma-irradiation [16888646]. Baxa transcription is induced by tp53 following gamma-irradiation in zebrafish embryos [15630097]. |
BCL2 |
BCL-2, B-CELL LEUKEMIA/LYMPHOMA 2, ZBLP2 |
Zebrafish |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
16888647,16888646,18404156,18510930 |
Bcl2 (B-cell leukemia/lymphoma 2). [Source:UniProtKB/TrEMBL;Acc:Q564A4] |
Ectopic expression of Bcl2 in zebrafish embryos inhibits apoptosis induced by multiple stimuli including death receptors [16888647], ectopic expression of several pro-apoptotic Bcl2 family members [16888646], and gamma-irradiation [16888646]. full-length zebrafish bcl2 protein binds strongly to the BH3 domain peptide from zebrafish bim, binds weakly to bida, bad, and bbc3, and does not bind at all to pmaip1 [18404156]. Zebrafish Bcl2 promotes survival following growth factor withdrawal in murine FL5.12 cells and binds directly to human Bim, Bax, and Puma in this context [18510930]. |
BAXB |
BAXB, ZBAX2, BCL2-ASSOCIATED X PROTEIN B, ZGC:112983 |
Zebrafish |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
16888646 |
hypothetical protein LOC503609 [Source:RefSeq_peptide;Acc:NP_001013314] |
Overexpression of Baxb in early stage zebrafish embryos induces caspase-3 activation and apoptosis [16888646]. Knockdown of Baxb using antisense morpholino oligonucleotides protects zebrafish embryos from apoptosis in response to gamma-irradiation [16888646].Ectopic expression induces apoptosis [16888646]. |
TNFSF10L3 |
TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY MEMBER 10 LIKE 3, DL1B, DR_TRAIL-LIKE V1 |
Zebrafish |
DEATH LIGAND |
APOPTOSIS |
EXTRINSIC PATHWAY |
16888647,17548633 |
tumor necrosis factor (ligand) superfamily, member 10 like 3 [Source:RefSeq_peptide;Acc:NP_001036178] |
Ectopic expression of Tnfsf10l3 in zebrafish embryos induces apoptosis in the notochord and erythroid cells [16888647] . Tnfsf10l3 directly associates with the zebrafish death receptor Hdr [16888647] . Tnfsf10l3-induced apoptosis can be blocked by ectopic expression of zebrafish Cflar or by knockdown of endogenous Hdr or FADD [16888647] . Zebrafish Tnfsf10l3 is more structurally related to Apo2L-like (a second copy of Apo2L/TRAIL found in avian species but not mammals) than to mammalian Apo2L/TRAIL due to additional cysteine residues in its extracellular domain 16888647 . |
TRADD |
TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN, ZGC:103556, WU:FC59E02 |
Zebrafish |
DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN |
APOPTOSIS |
EXTRINSIC PATHWAY |
16888647 |
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain protein). [Source:UniProtKB/Swiss-Prot;Acc:Q9I9N5] |
Ectopic expression of TRADD in zebrafish embryos induces apoptosis [16888647] . Knockdown of TRADD using antisense morpholino oligonucleotides does not protect zebrafish embryos from apoptosis induced by ectopic expression of Apo2L/TRAIL orthologs [16888647] . |
BMF2 |
BCL2 MODIFYING FACTOR 2, SI:CH211-119B12.7 |
Zebrafish |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
16888646 |
Bmf2 [Source:RefSeq_peptide;Acc:NP_001038938] |
Ectopic expression of Bmf2 in zebrafish embryos induces apoptosis [16888646]. |
FAS |
FAS LIGAND (TNF SUPERFAMILY, MEMBER 6), FAS |
Zebrafish |
DEATH RECEPTOR |
APOPTOSIS |
EXTRINSIC PATHWAY |
16888647 |
Fas (TNF receptor superfamily, member 6) [Source:RefSeq_peptide;Acc:XP_690447] |
Ectopic expression of Fas in zebrafish embryos and human cell lines induces apoptosis [16888647]. |
BIRC2 |
BACULOVIRAL IAP REPEAT-CONTAINING 2, IAP1, BIRC3 |
Zebrafish |
BIR-CONTAINING PROTEIN;IAP |
APOPTOSIS |
TNF/NF-KAPPAB SIGNALING |
17934460 |
baculoviral IAP repeat-containing 2 [Source:RefSeq_peptide;Acc:NP_919376] |
A loss of function mutation in the zebrafish Birc2 locus produces a hemorrhagic phenotype, vascular regression, and Caspase-8-dependent endothelial cell apoptosis [17934460]. Zebrafish Birc2 binds endogenous mammalian TRAF2 when transfected into HEK293 cells [17934460]. |
BIK |
BCL2-INTERACTING KILLER (APOPTOSIS-INDUCING), SI:DKEY-31F5.6 |
Zebrafish |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
16888646 |
BCL2-interacting killer (apoptosis-inducing) [Source:RefSeq_peptide;Acc:NP_001038503] |
Ectopic expression of Bik in zebrafish embryos induces apoptosis [16888646]. |
BOKA |
BCL2-RELATED OVARIAN KILLER A, BOK, ZBOK1, ZGC:100979 |
Zebrafish |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
UNDEFINED |
INTRINSIC PATHWAY |
16888646 |
Bcl-2-related ovarian killer protein homolog A (zBok1). [Source:UniProtKB/Swiss-Prot;Acc:Q6DC66] |
|
BAD |
BCL2-ANTAGONIST OF CELL DEATH, WU:FA01B12, PROAPOPTOTIC BH3-ONLY PROTEIN, FA01B12, WU:FA01B12, WU:FA96D04 |
Zebrafish |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY |
16888646,12727206,18404156 |
BCL2-antagonist of cell death [Source:RefSeq_peptide;Acc:NP_571654] |
Overexpression of Zebrafish Bad induces apoptosis. |
CASP3B |
CASPASE 3, APOPTOSIS-RELATED CYSTEINE PROTEASE B, CASPASE-3B, CASP3B, CASP3L |
Zebrafish |
CASPASE |
APOPTOSIS |
UNDEFINED |
16888647 |
caspase 3, apoptosis-related cysteine protease b [Source:RefSeq_peptide;Acc:NP_001041531] |
|
CFLAR |
CASP8 AND FADD-LIKE APOPTOSIS REGULATOR, CLARP1, FLIP |
Zebrafish |
CASPASE |
APOPTOSIS |
EXTRINSIC PATHWAY |
16888647 |
CASP8 and FADD-like apoptosis regulator [Source:RefSeq_peptide;Acc:NP_919380] |
Cflar contains N-terminal death effector domains (DEDs) and an enzymatically inactive caspase cataltic domain [16888647]. Ectopic expression of Cflar in zebrafish embryos prevents induction of apoptosis by the Apo2L/TRAIL orthologs [16888647]. |
TNFSF10L2 |
TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY MEMBER 10 LIKE 2, DL2, ZGC:92320, DR_TRAIL-LIKE V3 |
Zebrafish |
DEATH LIGAND |
APOPTOSIS |
EXTRINSIC PATHWAY |
16888647,17548633 |
tumor necrosis factor (ligand) superfamily, member 10 like 2 [Source:RefSeq_peptide;Acc:NP_001002593] |
Ectopic expression of Tnfsf10l2 in zebrafish embryos induces apoptosis in the notochord [16888647] . Tnfsf10l2 directly associates with the zebrafish death receptor Tnfrsfa and Tnfsf10l2-induced apoptosis can be blocked by knockdown of endogenous Tnfrsfa [16888647] . Zebrafish Tnfsf10l2 exhibits greater structural similarity to mammalian Apo2L/TRAIL than other zebrafish Apo2L/TRAIL homologs 16888647 . |
TNFSF10L4 |
TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY, MEMBER 10 LIKE 4, ZGC:113297, DL3, DR_TRAIL-LIKE V4 |
Zebrafish |
DEATH LIGAND |
UNDEFINED |
EXTRINSIC PATHWAY |
16888647,17548633 |
death ligand 3 [Source:RefSeq_peptide;Acc:NP_001013301] |
Zebrafish tnfsf10l4 shows greater sequence divergence from mammalian Apo2L/TRAIL than other zebrafish Apo2L/TRAIL homologs 16888647 . |
CASP8 |
CASPASE 8, CASPASE-8, ZCASPASE-8A, MGC92075, ZGC:92075 |
Zebrafish |
CASPASE |
APOPTOSIS |
EXTRINSIC PATHWAY |
16888647,17459614 |
caspase 8, apoptosis-related cysteine peptidase [Source:RefSeq_peptide;Acc:NP_571585] |
Ectopic expression of Casp8 in zebrafish embryos induces apoptosis [16888647]. Zebrafish Casp8 directly associates with FADD through homophilic death effector domain (DED) interactions [17459614]. Zebrafish Casp8 can mediate apoptosis following death receptor activation in mouse embryonic fibroblast cells that lack endogenous caspase-8 [17459614]. |
CASP2 |
CASPASE 2 |
Zebrafish |
CASPASE |
APOPTOSIS |
UNDEFINED |
16888647,18510930 |
caspase 2, apoptosis-related cysteine protease [Source:RefSeq_peptide;Acc:NP_001036160] |
Ectopic expression of Casp2 in zebrafish embryos induces apoptosis [16888647]. Checkpoint kinase 1 (Chk1) suppresses a Casp2-dependent apoptotic program in zebrafish that can mediate gamma-radiation-induced apoptosis [18510930]. |
BMF1 |
|
Zebrafish |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
16888646 |
Bcl2 modifying factor 1 [Source:RefSeq_peptide;Acc:NP_001038689] |
Ectopic expression of Bmf1 in zebrafish embryos induces apoptosis [16888646]. |
FADD |
FAS (TNFRSF6)-ASSOCIATED VIA DEATH DOMAIN |
Zebrafish |
DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN;DED ADAPTER PROTEIN |
APOPTOSIS |
EXTRINSIC PATHWAY |
16888647,17459614 |
Fas (tnfrsf6)-associated via death domain [Source:RefSeq_peptide;Acc:XP_001923893] |
Ectopic expression of Casp8 in zebrafish embryos and human cell lines induces apoptosis [16888647]. Knockdown of FADD using antisense morpholino oligonucleotides protects zebrafish embryos from apoptosis induced by ectopic expression of Apo2L/TRAIL orthologs [16888647]. Zebrafish FADD directly associates with Casp8 through homophilic death effector domain (DED) interactions [17459614]. |
BIDA |
BID, SI:CH211-238N5.6 |
Zebrafish |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
EXTRINSIC PATHWAY,INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
16888646,18404156,16888647 |
BH3 interacting domain death agonist [Source:RefSeq_peptide;Acc:NP_001073295] |
Ectopic expression of Bida in zebrafish embryos induces apoptosis [16888646,18404156]. Zebrafish Bida contains a putative caspase-8 cleavage site that may allow for proteolytic activation by the extrinsic apoptosis pathway [16888647]. The BH3 domain peptide from Bida binds weakly to the full-length zebrafish bcl2 protein [18404156]. |
CASP8L2 |
CASPASE 8, APOPTOSIS-RELATED CYSTEINE PEPTIDASE LIKE 2,CASP8L2, CASPASE-8B |
Zebrafish |
CASPASE |
APOPTOSIS |
UNDEFINED |
16888647 |
caspase 8, apoptosis-related cysteine peptidase, like 2 [Source:RefSeq_peptide;Acc:XP_685430] |
Casp8l2 contains N-terminal death effector domains (DEDs) similar to mammalian Caspase-8 but has a QACRG active site motif that is more reminiscent of mammalian Caspase-2 [16888647]. |
PMAIP1 |
PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1, NOXA, ZGC:162379 |
Zebrafish |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
16888646,18404156 |
phorbol-12-myristate-13-acetate-induced protein 1 [Source:RefSeq_peptide;Acc:NP_001038939] |
Ectopic expression of Pmaip1 in zebrafish embryos induces apoptosis [ Ref: 16888646 , Ref: 18404156 "> Ref: Ref: 18404156 ]. The BH3 domain peptide from zebrafish Pmaip1 induces cytochrome c release in mitochondria isolated from mouse embryonic fibroblasts (MEFs) [ Ref: 18404156 "> Ref: Ref: 18404156 ]. |
BAD |
BCL2L8, BBC2 |
Human |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
7834748 |
Bcl2 antagonist of cell death (BAD)(Bcl-2-binding component 6)(Bcl-XL/Bcl-2-associated death promoter)(Bcl-2-like 8 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q92934] |
The murine counterpart for Bad participates in regulation of glucose metabolism |
CASP10 |
MCH4 |
Human |
CASPASE |
APOPTOSIS |
EXTRINSIC PATHWAY |
8755496 |
Caspase-10 Precursor (CASP-10)(EC 3.4.22.63)(ICE-like apoptotic protease 4)(Apoptotic protease Mch-4)(FAS-associated death domain protein interleukin-1B-converting enzyme 2)(FLICE2) [Contains Caspase-10 subunit p23/17;Caspase-10 subunit p12] [Source:UniProtKB/Swiss-Prot;Acc:Q92851] |
|
CFLAR |
CASH, CASPER, CLARP, FLAME, FLIP, I-FLICE, MRIT |
Human |
CASPASE,DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN;OTHER |
APOPTOSIS |
EXTRINSIC PATHWAY |
9217161 |
CASP8 and FADD-like apoptosis regulator Precursor (Cellular FLICE-like inhibitory protein)(c-FLIP)(Caspase-eight-related protein)(Casper)(Caspase-like apoptosis regulatory protein)(CLARP)(MACH-related inducer of toxicity)(MRIT)(Caspase homolog)(CASH)(Inhibitor of FLICE)(I-FLICE)(FADD-like antiapoptotic molecule 1)(FLAME-1)(Usurpin) [Contains CASP8 and FADD-like apoptosis regulator subunit p43;CASP8 and FADD-like apoptosis regulator subunit p12] [Source:UniProtKB/Swiss-Prot;Acc:O15519] |
|
AK2 |
|
Human |
OTHER |
|
|
9434148,9894606 |
Adenylate kinase isoenzyme 2, mitochondrial (AK 2)(EC 2.7.4.3)(ATP-AMP transphosphorylase 2) [Source:UniProtKB/Swiss-Prot;Acc:P54819] |
Adenilate kinase-2 is released from mitochondria during apoptosis, but its function remains unknown |
BID |
|
Human |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
EXTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
8918887 |
BH3-interacting domain death agonist (p22 BID)(BID) [Contains BH3-interacting domain death agonist p15(p15 BID);BH3-interacting domain death agonist p13(p13 BID);BH3-interacting domain death agonist p11(p11 BID)] [Source:UniProtKB/Swiss-Prot;Acc:P55957] |
|
BIRC3 |
CIAP2, HIAP-1, MIHC, RNF49, MALT2 |
Human |
BIR-CONTAINING PROTEIN;IAP |
APOPTOSIS,IMMUNITY |
TNF/NF-KAPPAB SIGNALING |
194641989,16339151 |
Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1)(HIAP-1)(HIAP1)(C-IAP2)(TNFR2-TRAF-signaling complex protein 1)(IAP homolog C)(Apoptosis inhibitor 2)(API2)(RING finger protein 49) [Source:UniProtKB/Swiss-Prot;Acc:Q13489] |
|
FAS |
CD95, APO-1 |
Human |
DEATH RECEPTOR |
APOPTOSIS |
EXTRINSIC PATHWAY |
1713127 |
Tumor necrosis factor receptor superfamily member 6 Precursor (FASLG receptor)(Apoptosis-mediating surface antigen FAS)(Apo-1 antigen)(CD95 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P25445] |
|
TNFRSF1B |
TNFBR, TNFR80, TNF-R75, TNF-R-II, P75, CD120B |
Human |
DEATH RECEPTOR |
APOPTOSIS |
EXTRINSIC PATHWAY,TNF/NF-KAPPAB SIGNALING |
11239407,7876558 |
Tumor necrosis factor receptor superfamily member 1B Precursor (Tumor necrosis factor receptor 2)(TNF-R2)(Tumor necrosis factor receptor type II)(p75)(p80 TNF-alpha receptor)(CD120b antigen)(Etanercept) [Contains Tumor necrosis factor receptor superfamily member 1b, membrane form;Tumor necrosis factor-binding protein 2(TBPII)(TBP-2)] [Source:UniProtKB/Swiss-Prot;Acc:P20333] |
|
BAK1 |
BAK2 |
Human |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
7715730 |
Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK)(Bcl-2-like 7 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q16611] |
|
TRAF1 |
EBI6 |
Human |
OTHER |
IMMUNITY |
TNF/NF-KAPPAB SIGNALING |
8069916 |
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) [Source:UniProtKB/Swiss-Prot;Acc:Q13077] |
|
CASP8 |
MCH5, MACH, FLICE |
Human |
CASPASE |
APOPTOSIS |
EXTRINSIC PATHWAY |
8681376 |
Caspase-8 Precursor (CASP-8)(EC 3.4.22.61)(ICE-like apoptotic protease 5)(MORT1-associated CED-3 homolog)(MACH)(FADD-homologous ICE/CED-3-like protease)(FADD-like ICE)(FLICE)(Apoptotic cysteine protease)(Apoptotic protease Mch-5)(CAP4) [Contains Caspase-8 subunit p18;Caspase-8 subunit p10] [Source:UniProtKB/Swiss-Prot;Acc:Q14790] |
|
TNFRSF1A |
TNF-R, TNFAR, TNFR60, TNF-R-I, CD120A, TNF-R55 |
Human |
DEATH RECEPTOR |
APOPTOSIS,NECROPTOSIS |
EXTRINSIC PATHWAY,TNF/NF-KAPPAB SIGNALING |
8397073,11239407 |
Tumor necrosis factor receptor superfamily member 1A Precursor (p60)(TNF-R1)(TNF-RI)(TNFR-I)(p55)(CD120a antigen) [Contains Tumor necrosis factor receptor superfamily member 1A, membrane form;Tumor necrosis factor-binding protein 1(TBPI)] [Source:UniProtKB/Swiss-Prot;Acc:P19438] |
|
ICAM3 |
|
Human |
|
APOPTOSIS |
APOPTOTIC CELL CLEARANCE |
18073771 |
Intercellular adhesion molecule 3 Precursor (ICAM-3)(ICAM-R)(CDw50)(CD50 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P32942] |
|
BIRC1 |
NLRB1 |
Human |
OTHER |
IMMUNITY |
INFLAMMASOME |
8552191,18854135 |
Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein) [Source:UniProtKB/Swiss-Prot;Acc:Q13075] |
|
CYLD |
|
Human |
OTHER |
APOPTOSIS |
EXTRINSIC PATHWAY |
18485876 |
Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15)(Ubiquitin thioesterase CYLD)(Ubiquitin-specific-processing protease CYLD)(Deubiquitinating enzyme CYLD) [Source:UniProtKB/Swiss-Prot;Acc:Q9NQC7] |
|
BAX |
BCL2L4 |
Human |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
8358790 |
Apoptosis regulator BAX [Source:UniProtKB/Swiss-Prot;Acc:Q07812] |
|
BIRC5 |
|
Human |
BIR-CONTAINING PROTEIN;OTHER |
CELL DEATH (OTHER) |
|
9256286,11329368,16962308 |
Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin)(Apoptosis inhibitor 4) [Source:UniProtKB/Swiss-Prot;Acc:O15392] |
Survivin is a protein with homology to IAPs but whose main role is the regulation of mitosis, not cell death. |
NLRP1 |
KIAA0926, DKFZP586O1822, CARD7, NAC, CLR17.1, DEFCAP |
Human |
CARD-CONTAINING PROTEIN;CARD ADAPTER PROTEIN |
IMMUNITY |
INFLAMMASOME |
12563287,15952891 |
NACHT, LRR and PYD domains-containing protein 1 (Death effector filament-forming ced-4-like apoptosis protein)(Nucleotide-binding domain and caspase recruitment domain)(Caspase recruitment domain-containing protein 7) [Source:UniProtKB/Swiss-Prot;Acc:Q9C000] |
|
SH3GLB1 |
CGI-61, KIAA0491, BIF-1 |
Human |
OTHER |
APOPTOSIS |
INTRINSIC PATHWAY |
11259440,19074440 |
Endophilin-B1 (SH3 domain-containing GRB2-like protein B1)(Bax-interacting factor 1)(Bif-1) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y371] |
|
BCL2L13 |
MIL1, BCL-RAMBO, RAMBO |
Human |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
|
|
11262395 |
Bcl-2-like 13 protein (Protein Mil1)(Bcl-rambo) [Source:UniProtKB/Swiss-Prot;Acc:Q9BXK5] |
|
BIK |
NBK/BLK |
Human |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
8816500,11884414 |
Bcl-2-interacting killer (Apoptosis inducer NBK)(BP4)(BIP1) [Source:UniProtKB/Swiss-Prot;Acc:Q13323] |
|
GZMB |
GRB, GRANZYME B |
Human |
OTHER; |
|
|
11278459,17283187 |
Granzyme B Precursor (EC 3.4.21.79)(Granzyme-2)(T-cell serine protease 1-3E)(Cytotoxic T-lymphocyte proteinase 2)(Lymphocyte protease)(SECT)(Cathepsin G-like 1)(CTSGL1)(CTLA-1)(Fragmentin-2)(Human lymphocyte protein)(HLP)(C11) [Source:UniProtKB/Swiss-Prot;Acc:P10144] |
Human Granzyme B induces apoptosis mainly through Bid cleavage. |
XIAP |
HILP |
Human |
BIR-CONTAINING PROTEIN;IAP |
APOPTOSIS |
INTRINSIC PATHWAY,EXTRINSIC PATHWAY |
9230442 |
Baculoviral IAP repeat-containing protein 4 (EC 6.3.2.-)(E3 ubiquitin-protein ligase XIAP)(Inhibitor of apoptosis protein 3)(X-linked inhibitor of apoptosis protein)(X-linked IAP)(IAP-like protein)(HILP) [Source:UniProtKB/Swiss-Prot;Acc:P98170] |
|
TRADD |
HS.89862 |
Human |
DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN |
APOPTOSIS |
EXTRINSIC PATHWAY |
7758105 |
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein)(TNFRSF1A-associated via death domain) [Source:UniProtKB/Swiss-Prot;Acc:Q15628] |
|
PYCARD |
TMS-1, CARD5, ASC |
Human |
CARD-CONTAINING PROTEIN;CARD ADAPTER PROTEIN |
IMMUNITY |
INFLAMMASOME |
10567338,11103776 |
Apoptosis-associated speck-like protein containing a CARD (hASC)(PYD and CARD domain-containing protein)(Target of methylation-induced silencing 1)(Caspase recruitment domain-containing protein 5) [Source:UniProtKB/Swiss-Prot;Acc:Q9ULZ3] |
|
BMF |
FLJ00065 |
Human |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
11546872,19109899 |
Bcl-2-modifying factor [Source:UniProtKB/Swiss-Prot;Acc:Q96LC9] |
|
TRAIL-R1, DR4 |
TNFRSF10A, DR4, CD261 |
Human |
DEATH RECEPTOR |
APOPTOSIS |
EXTRINSIC PATHWAY |
9082980 |
Tumor necrosis factor receptor superfamily member 10A Precursor (Death receptor 4)(TNF-related apoptosis-inducing ligand receptor 1)(TRAIL receptor 1)(TRAIL-R1)(CD261 antigen) [Source:UniProtKB/Swiss-Prot;Acc:O00220] |
|
BNIP3L |
NIX, BNIP3A |
Human |
BCL-2 FAMILY;BH3-ONLY |
CELL DEATH (OTHER),APOPTOSIS |
|
9575197,19136941 |
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (NIP3-like protein X)(NIP3L)(BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A)(Adenovirus E1B19K-binding protein B5) [Source:UniProtKB/Swiss-Prot;Acc:O60238] |
|
CASPASE-14 |
CASP14, CASPASE 14, MICE, MGC119078, MGC119079 |
Human |
CASPASE |
CELL DEATH (OTHER) |
UNDEFINED |
10203698,11175259 |
Caspase-14 Precursor (CASP-14)(EC 3.4.22.-) [Source:UniProtKB/Swiss-Prot;Acc:P31944] |
Caspase-14 is associated with death of skin cells in a non-apoptotic manner |
PUMA |
JFY1, PUMA, BBC3 |
Human |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
11463391,11463392,11572983 |
Bcl-2-binding component 3 (p53 up-regulated modulator of apoptosis)(JFY-1) |
|
CASP2 |
ICH1 |
Human |
CASPASE |
|
|
8087842,19581929,9573047 |
Caspase-2 Precursor (CASP-2)(EC 3.4.22.55)(ICH-1 protease)(Neural precursor cell expressed developmentally down-regulated protein 2)(NEDD-2) [Contains Caspase-2 subunit p18;Caspase-2 subunit p13;Caspase-2 subunit p12] [Source:UniProtKB/Swiss-Prot;Acc:P42575] |
|
MAPK8 |
JNK, JNK1, SAPK1 |
Human |
OTHER |
CELL DEATH (OTHER) |
TNF/NF-KAPPAB SIGNALING |
8137421 |
Mitogen-activated protein kinase 8 (EC 2.7.11.24)(Stress-activated protein kinase JNK1)(c-Jun N-terminal kinase 1)(JNK-46) [Source:UniProtKB/Swiss-Prot;Acc:P45983] |
|
CIAP1 |
BIRC2, CIAP1, HIAP-2, MIHB, RNF48 |
Human |
BIR-CONTAINING PROTEIN;IAP |
APOPTOSIS,IMMUNITY,NECROPTOSIS |
TNF/NF-KAPPAB SIGNALING |
194641989,16339151,18022363,18022362,19012953 |
Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2)(HIAP-2)(C-IAP1)(TNFR2-TRAF-signaling complex protein 2)(IAP homolog B)(RING finger protein 48) |
|
GAPDH |
GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE |
Human |
OTHER |
CELL DEATH (OTHER) |
UNDEFINED |
17540177 |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) |
GAPDH contributes to recovery from caspase-independent cell death (CICD) after mitochondrial permeabilization [17540177] |
HTRA2 |
OMI, PARK13 |
Human |
OTHER |
CELL DEATH (OTHER) |
POSTMITOCHONDRIAL CASPASE ACTIVATION |
11583623 |
Serine protease HTRA2, mitochondrial Precursor (EC 3.4.21.108)(High temperature requirement protein A2)(HtrA2)(Omi stress-regulated endoprotease)(Serine proteinase OMI)(Serine protease 25) [Source:UniProtKB/Swiss-Prot;Acc:O43464] |
|
FASL |
FASL, CD178, FAS LIGAND |
Human |
DEATH LIGAND |
APOPTOSIS |
EXTRINSIC PATHWAY |
7505205 |
Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand)(Fas ligand)(CD95L protein)(Apoptosis antigen ligand)(APTL)(CD178 antigen) [Contains Tumor necrosis factor ligand superfamily member 6, membrane form;Tumor necrosis factor ligand superfamily member 6, soluble form] |
|
APAF1 |
CED4 |
Human |
CARD-CONTAINING PROTEIN;CARD ADAPTER PROTEIN |
APOPTOSIS |
INTRINSIC PATHWAY,POST-MITOCHONDRIAL CASPASE ACTIVATION |
9267021,15103327 |
Apoptotic protease-activating factor 1 (Apaf-1) [Source:UniProtKB/Swiss-Prot;Acc:O14727] |
|
TRAIL-R2, TNFRSF10B |
TNFRSF10B, TRAIL-R2, DR5, KILLER, TRICK2A, TRICK2B, APO-2, CD262 |
Human |
DEATH RECEPTOR |
APOPTOSIS |
EXTRINSIC PATHWAY |
9311998,9325248,9242611 |
Tumor necrosis factor receptor superfamily member 10B Precursor (Death receptor 5)(TNF-related apoptosis-inducing ligand receptor 2)(TRAIL receptor 2)(TRAIL-R2)(CD262 antigen) [Source:UniProtKB/Swiss-Prot;Acc:O14763] |
|
BCL2L14 |
BCLG, BCL-G |
Human |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
|
11054413 |
Apoptosis facilitator Bcl-2-like 14 protein (Apoptosis regulator Bcl-G) [Source:UniProtKB/Swiss-Prot;Acc:Q9BZR8] |
|
TNFSF10 |
TRAIL, APO-2L, APO2L TL2, CD253 |
Human |
DEATH LIGAND |
APOPTOSIS |
EXTRINSIC PATHWAY |
8663110 |
Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand)(Protein TRAIL)(Apoptosis ligand 2, Apo-2 ligand)(Apo-2L)(Apo2L)(CD253 antigen) |
|
LRP1 |
CD91 |
Human |
OTHER; |
APOPTOSIS |
APOPTOTIC CELL CLEARANCE |
16239148,18073771 |
Prolow-density lipoprotein receptor-related protein 1 Precursor (LRP)(Alpha-2-macroglobulin receptor)(A2MR)(Apolipoprotein E receptor)(APOER)(CD91 antigen) [Contains Low-density lipoprotein receptor-related protein 1 85 kDa subunit(LRP-85);Low-density lipoprotein receptor-related protein 1 515 kDa subunit(LRP-515);Low-density lipoprotein receptor-related protein 1 intracellular domain(LRPICD)] [Source:UniProtKB/Swiss-Prot;Acc:Q07954] |
|
CSE1L |
CAS, XPO2, CSE1 |
Human |
OTHER |
APOPTOSIS |
EXTRINSIC PATHWAY,POST-MITOCHONDRIAL CASPASE ACTIVATION |
18439902 |
Exportin-2 (Exp2)(Importin-alpha re-exporter)(Chromosome segregation 1-like protein)(Cellular apoptosis susceptibility protein) [Source:UniProtKB/Swiss-Prot;Acc:P55060] |
|
BCL2L12 |
BCL-2L12 |
Human |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
UNDEFINED |
11401436,19617565,17210792,18669646 |
Bcl-2-related proline-rich protein (Bcl-2-like 12 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9HB09] |
It is still debated if Bcl-2L12 has a pro- or antiapoptotic function. Data from Nakajima et al. point towards a slightly pro-apoptotic function that is cell-type specific and so far only shown with UV irradation. On the other hand, the inhibiting function of Bcl-2L12 on caspase-3/-7 downstream of mitochondria cannot be reproduced. |
TRAF2 |
TRAP3 |
Human |
OTHER |
IMMUNITY |
TNF/NF-KAPPAB SIGNALING |
8069916,8702708 |
TNF receptor-associated factor 2 (Tumor necrosis factor type 2 receptor-associated protein 3) [Source:UniProtKB/Swiss-Prot;Acc:Q12933] |
|
RIPK3 |
|
Human |
OTHER |
NECROPTOSIS |
TNF/NF-KAPPAB SIGNALING |
19524512,19524513 |
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1)(RIP-like protein kinase 3)(Receptor-interacting protein 3)(RIP-3) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y572] |
|
BCL2L2 |
KIAA0271, BCL-W |
Human |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
8761287 |
Apoptosis regulator Bcl-W (Bcl-2-like 2 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q92843] |
|
XAF1 |
|
Human |
OTHER |
APOPTOSIS |
|
11175744 |
XIAP-associated factor 1 (BIRC4-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:Q6GPH4] |
|
CASP9 |
CASPASE-9, CASPASE 9, CASP9, MCH6, ICE-LAP6, APAF-3 |
Human |
CASPASE |
APOPTOSIS |
INTRINSIC PATHWAY |
8900201 |
Caspase-9 Precursor (CASP-9)(EC 3.4.22.62)(ICE-like apoptotic protease 6)(ICE-LAP6)(Apoptotic protease Mch-6)(Apoptotic protease-activating factor 3)(APAF-3) [Contains Caspase-9 subunit p35;Caspase-9 subunit p10] [Source:UniProtKB/Swiss-Prot;Acc:P55211] |
Caspase-9 is the binding partner of Apaf-1, becoming activated upon binding to the latter in response to mitochondrial cytochrome c efflux.
Apaf-1 and caspase-9 form a holoenzyme (called the apoptosome) which is comprised of seven molecules of Apaf-1 and possibly a similar number of caspase-9 molecules (although the precise number of caspase-9 molecules within the apoptosome may be as low as 1 or 2).
Upon activation within the apoptosome, caspase-9 then directly processes and activates caspases -3 and -7 downstream.
Other than caspases -3 and -7, few other substrates for caspase-9 are known. |
ANXA1 |
ANX1, LPC1, ANNEXIN-1, LIPOCORTIN I |
Human |
OTHER |
APOPTOSIS |
APOPTOTIC CELL CLEARANCE |
17372018,18073771 |
Annexin A1 (Annexin-1)(Annexin I)(Lipocortin I)(Calpactin II)(Chromobindin-9)(p35)(Phospholipase A2 inhibitory protein) [Source:UniProtKB/Swiss-Prot;Acc:P04083] |
|
HRK |
DP5 |
Human |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY |
9130713,9228060 |
Activator of apoptosis harakiri (Neuronal death protein DP5)(BH3-interacting domain-containing protein 3) [Source:UniProtKB/Swiss-Prot;Acc:O00198] |
|
RIPK1 |
RIP |
Human |
DEATH DOMAIN-CONTAINING PROTEIN;OTHER |
NECROPTOSIS,APOPTOSIS |
TNF/NF-KAPPAB SIGNALING |
18408713,18485876 |
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1)(Serine/threonine-protein kinase RIP)(Cell death protein RIP)(Receptor-interacting protein) [Source:UniProtKB/Swiss-Prot;Acc:Q13546] |
|
CASP1 |
ICE, CASPASE-1, CASPASE 1, CASP1 |
Human |
CASPASE |
IMMUNITY |
INFLAMMASOME |
1373520,11967258 |
Caspase-1 Precursor (CASP-1)(EC 3.4.22.36)(Interleukin-1 beta convertase)(IL-1BC)(Interleukin-1 beta-converting enzyme)(IL-1 beta-converting enzyme)(ICE)(p45) [Contains Caspase-1 subunit p20;Caspase-1 subunit p10] [Source:UniProtKB/Swiss-Prot;Acc:P29466] |
Caspase-1 is instrumental in processing the precursor forms of interleukin-1beta and interleukin-18 to their biologically active forms.
Although quite a few other substrates for caspase-1 have been claimed, these have invariably been found using non-physiological concentrations of caspase-1 (i.e. at concentrations in excess of 200 nanoMolar, sometimes ridiculously so) and are therefore unlikely to be genuine substrates.
So, to date, there are two natural substrates for caspase-1 known (IL-1beta and IL-18). |
CASP5 |
ICE(REL)III |
Human |
CASPASE |
IMMUNITY |
INFLAMMASOME |
15163405,8617266 |
Caspase-5 Precursor (CASP-5)(EC 3.4.22.58)(ICH-3 protease)(TY protease)(ICE(rel)-III) [Contains Caspase-5 subunit p20;Caspase-5 subunit p10] [Source:UniProtKB/Swiss-Prot;Acc:P51878] |
|
BCL2L10 |
DIVA, BOO, BCL-B |
Human |
BCL-2 FAMILY,BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY |
9878060,9829980 |
Apoptosis regulator Bcl-B (Bcl-2-like 10 protein)(Bcl2-L-10)(Anti-apoptotic protein NrH) [Source:UniProtKB/Swiss-Prot;Acc:Q9HD36] |
|
CASP6 |
MCH2 |
Human |
CASPASE |
APOPTOSIS |
|
7796396 |
Caspase-6 Precursor (CASP-6)(EC 3.4.22.59)(Apoptotic protease Mch-2) [Contains Caspase-6 subunit p18;Caspase-6 subunit p11] [Source:UniProtKB/Swiss-Prot;Acc:P55212] |
|
PHAP |
PHAP, ANP32A, LANP, PP32, I1PP2A, PHAPI, MAPM, MAPMODULIN |
Human |
OTHER |
APOPTOSIS |
POST-MITOCHONDRIAL CASPASE ACTIVATION |
12522243 |
Acidic leucine-rich nuclear phosphoprotein 32 family member A (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A)(Acidic nuclear phosphoprotein pp32)(Leucine-rich acidic nuclear protein)(Lanp)(Putative HLA-DR-associated protein I)(PHAPI)(Mapmodulin) [Source:UniProtKB/Swiss-Prot;Acc:P39687] |
|
BCL2A1 |
GRS, BFL1, BCL2L5, ACC-1, ACC-2, A1 |
Human |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
11929871 |
Bcl-2-related protein A1 (Protein BFL-1)(Hemopoietic-specific early response protein)(Protein GRS) [Source:UniProtKB/Swiss-Prot;Acc:Q16548] |
|
ARC |
NOL3, ARC |
Human |
CARD-CONTAINING PROTEIN;OTHER |
UNDEFINED |
UNDEFINED |
9560245 |
Nucleolar protein 3 (Apoptosis repressor with CARD)(Muscle-enriched cytoplasmic protein)(Myp)(Nucleolar protein of 30 kDa)(Nop30) [Source:UniProtKB/Swiss-Prot;Acc:O60936] |
The exact role of this protein during apoptosis is still undetermined |
TP53 |
P53, LFS1 |
Human |
OTHER |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
19410540,1584781 |
Cellular tumor antigen p53 (Tumor suppressor p53)(Phosphoprotein p53)(Antigen NY-CO-13) [Source:UniProtKB/Swiss-Prot;Acc:P04637] |
|
NOXA |
PMAIP1, APR, NOXA |
Human |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
10807576 |
Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1)(Immediate-early-response protein APR)(NOXA) |
|
MCL1 |
BCL2L3 |
Human |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
7682708,10837489 |
Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-related protein EAT/mcl1)(mcl1/EAT) [Source:UniProtKB/Swiss-Prot;Acc:Q07820] |
|
BCL2L11 |
BOD, BIML, BIMEL, BIM |
Human |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
9430630,19641506 |
Bcl-2-like protein 11 (Bcl2-interacting mediator of cell death) [Source:UniProtKB/Swiss-Prot;Acc:O43521] |
|
AIF |
AIF, AIFM1 |
Human |
OTHER |
CELL DEATH (OTHER) |
UNDEFINED |
9989411,15526035 |
Apoptosis-inducing factor 1, mitochondrial Precursor (EC 1.-.-.-)(Programmed cell death protein 8) |
The role of this protein during cell death requires further clarification |
NLRP3 |
AGTAVPRL, AII, AVP, FCAS, FCU, NALP3, PYPAF1, MWS, CLR1.1 |
Human |
OTHER |
IMMUNITY |
INFLAMMASOME |
12563287,15952891 |
NACHT, LRR and PYD domains-containing protein 3 (Cold autoinflammatory syndrome 1 protein)(Cryopyrin)(PYRIN-containing APAF1-like protein 1)(Angiotensin/vasopressin receptor AII/AVP-like) [Source:UniProtKB/Swiss-Prot;Acc:Q96P20] |
|
CASP3 |
CPP32, CPP32B, YAMA, APOPAIN |
Human |
CASPASE |
APOPTOSIS |
INTRINSIC PATHWAY,EXTRINSIC PATHWAY |
7983002 |
Caspase-3 Precursor (CASP-3)(EC 3.4.22.56)(Apopain)(Cysteine protease CPP32)(CPP-32)(Yama protein)(SREBP cleavage activity 1)(SCA-1) [Contains Caspase-3 subunit p17;Caspase-3 subunit p12] [Source:UniProtKB/Swiss-Prot;Acc:P42574] |
|
CASP7 |
MCH3, CMH-1, ICE-LAP3 |
Human |
CASPASE |
APOPTOSIS |
INTRINSIC PATHWAY,EXTRINSIC PATHWAY |
8521391,9070923 |
Caspase-7 Precursor (CASP-7)(EC 3.4.22.60)(ICE-like apoptotic protease 3)(ICE-LAP3)(Apoptotic protease Mch-3)(CMH-1) [Contains Caspase-7 subunit p20;Caspase-7 subunit p11] [Source:UniProtKB/Swiss-Prot;Acc:P55210] |
|
MOAP1 |
MAP-1, PNMA4 |
Human |
OTHER |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
16199525 |
Modulator of apoptosis 1 (MAP-1)(MAP1)(Paraneoplastic antigen Ma4) [Source:UniProtKB/Swiss-Prot;Acc:Q96BY2] |
|
ENDOG |
|
Human |
OTHER |
CELL DEATH (OTHER) |
|
16754658,11452314 |
Endonuclease G, mitochondrial Precursor (Endo G)(EC 3.1.30.-) [Source:UniProtKB/Swiss-Prot;Acc:Q14249] |
|
FADD |
MORT1, GIG3 |
Human |
DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN,DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN;DED ADAPTER PROTEIN |
APOPTOSIS |
EXTRINSIC PATHWAY |
7538907 |
Protein FADD (FAS-associated death domain protein)(FAS-associating death domain-containing protein)(Mediator of receptor induced toxicity) [Source:UniProtKB/Swiss-Prot;Acc:Q13158] |
|
CRADD |
RAIDD |
Human |
DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN |
APOPTOSIS |
|
8985253,15073321,15947787 |
Death domain-containing protein CRADD (Caspase and RIP adapter with death domain)(RIP-associated protein with a death domain) [Source:UniProtKB/Swiss-Prot;Acc:P78560] |
|
AVEN |
PDCD12 |
Human |
OTHER |
APOPTOSIS |
INTRINSIC PATHWAY |
10949025 |
Cell death regulator Aven [Source:UniProtKB/Swiss-Prot;Acc:Q9NQS1] |
|
BCL2L1 |
BCLX, BCL2L, BCL-X, BCL-XL, BCL-XS |
Human |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
8358789 |
Apoptosis regulator Bcl-X (Bcl-2-like 1 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q07817] |
|
BCL2 |
BCL-2 |
Human |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
2848196 |
Apoptosis regulator Bcl-2 [Source:UniProtKB/Swiss-Prot;Acc:P10415] |
|
CYTOCHROME C |
HCS, CYCS |
Human |
OTHER |
APOPTOSIS |
INTRINSIC PATHWAY,POST-MITOCHONDRIAL CASPASE ACTIVATION |
8689682,15907471 |
Cytochrome c [Source:UniProtKB/Swiss-Prot;Acc:P99999] |
Cytochrome c is a nuclear encoded gene that upon import into the mitochondria obtains a heme moiety forming the holoenzyme. In healthy cells, cytochrome c resides in the mitochondrial intermembrane space where it is required for oxidative phosphorylation by transferring electrons between complexes III and IV of the respiratory chain. During apoptosis, cytochrome c is released from mitochondria following mitochondrial outer membrane permeabilisation where it drives caspase activation [8689682] . Once in the cytosol, cytochrome c binds Apaf-1 leading to formation of the heptameric Apaf-1 caspase activating platform termed the apoptosome. Cytochrome c is absolutely required for caspase activation in the majority of intrinsic apoptosis pathways 1590747 |
MALT1 |
|
Human |
OTHER |
IMMUNITY |
|
14576442 |
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-)(MALT lymphoma-associated translocation)(Paracaspase) [Source:UniProtKB/Swiss-Prot;Acc:Q9UDY8] |
|
TRAIL-R4, TNFRSF10D |
TNFRSF10D, TRAIL-R4, DCR2, TRUNDD, CD264 |
Human |
DEATH RECEPTOR |
APOPTOSIS |
EXTRINSIC PATHWAY |
9382840 |
(TNF-related apoptosis-inducing ligand receptor 4)(TRAIL receptor 4)(TRAIL-R4) Tumor necrosis factor receptor superfamily member 10D Precursor (Decoy receptor 2)(DcR2) (TRAIL receptor with a truncated death domain)(CD264 antigen) [Source:UniProtKB/Swiss-Prot;Acc:Q9UBN6] |
|
TRAIL-R3 / TNFSF10C |
TNFRSF10C, TRAIL-R3, DCR1, LIT, TRID, CD263 |
Human |
OTHER |
APOPTOSIS |
EXTRINSIC PATHWAY |
9314565 |
Tumor necrosis factor receptor superfamily member 10C Precursor (Decoy receptor 1)(DcR1)(Decoy TRAIL receptor without death domain)(TNF-related apoptosis-inducing ligand receptor 3)(TRAIL receptor 3)(TRAIL-R3)(Trail receptor without an intracellular domain)(Lymphocyte inhibitor of TRAIL)(Antagonist decoy receptor for TRAIL/Apo-2L)(CD263 antigen) [Source:UniProtKB/Swiss-Prot;Acc:O14798] |
|
BNIP3 |
NIP3 |
Human |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY |
9867803 |
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Source:UniProtKB/Swiss-Prot;Acc:Q12983] |
|
BOK |
BCL2L9, BOKL, MGC4631 |
Human |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
CELL DEATH (OTHER) |
|
16302269,9535847 |
Bcl-2-related ovarian killer protein (Hbok) [Source:UniProtKB/Swiss-Prot;Acc:Q9UMX3] |
|
LRDD |
PIDD, MGC16925, DKFZP434D229 |
Human |
DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN |
|
|
10973264,15073321 |
Leucine-rich repeat and death domain-containing protein (p53-induced protein with a death domain) [Source:UniProtKB/Swiss-Prot;Acc:Q9HB75] |
|
CALR |
|
Human |
OTHER; |
APOPTOSIS |
APOPTOTIC CELL CLEARANCE |
16239148,18073771 |
Calreticulin Precursor (CRP55)(Calregulin)(HACBP)(ERp60)(grp60) [Source:UniProtKB/Swiss-Prot;Acc:P27797] |
|
DIABLO |
SMAC, DIABLO-S, FLJ25049, FLJ10537 |
Human |
IAP ANTAGONIST |
APOPTOSIS |
INTRINSIC PATHWAY |
10929711 |
Diablo homolog, mitochondrial Precursor (Second mitochondria-derived activator of caspase)(Smac protein)(Direct IAP-binding protein with low pI) [Source:UniProtKB/Swiss-Prot;Acc:Q9NR28] |
|
CASP4 |
ICE(REL)II, ICH-2, TX |
Human |
CASPASE |
IMMUNITY |
|
7743998,15123740 |
Caspase-4 Precursor (CASP-4)(EC 3.4.22.57)(ICH-2 protease)(TX protease)(ICE(rel)-II) [Contains Caspase-4 subunit 1;Caspase-4 subunit 2] [Source:UniProtKB/Swiss-Prot;Acc:P49662] |
|
OPA1 |
|
Human |
OTHER |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
18691924,16115883 |
Dynamin-like 120 kDa protein, mitochondrial Precursor (Optic atrophy protein 1) [Contains Dynamin-like 120 kDa protein, form S1] [Source:UniProtKB/Swiss-Prot;Acc:O60313] |
|
CASP12 |
|
Human |
CASPASE |
IMMUNITY |
INFLAMMASOME |
10638761 |
Inactive caspase-12 (CASP-12) [Source:UniProtKB/Swiss-Prot;Acc:Q6UXS9] |
|
TNF |
TNFSF2, DIF, TNF-ALPHA |
Human |
DEATH LIGAND |
APOPTOSIS,IMMUNITY |
EXTRINSIC PATHWAY,TNF/NF-KAPPAB SIGNALING |
6392892 |
Tumor necrosis factor Precursor (TNF-alpha)(Tumor necrosis factor ligand superfamily member 2)(TNF-a)(Cachectin) [Contains Tumor necrosis factor, membrane form;Tumor necrosis factor, soluble form] [Source:UniProtKB/Swiss-Prot;Acc:P01375] |
|
FASL |
FASL, FAS LIGAND (TNF SUPERFAMILY, MEMBER 6) |
Mouse |
DEATH LIGAND |
APOPTOSIS |
EXTRINSIC PATHWAY |
7511063 |
Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand)(Fas ligand)(CD95L protein)(CD178 antigen) [Contains Tumor necrosis factor ligand superfamily member 6, membrane form;Tumor necrosis factor ligand superfamily member 6, soluble form] [Source:UniProtKB/Swiss-Prot;Acc:P41047] |
|
BBC3 |
BBC3, BCL2 BINDING COMPONENT 3, PUMA |
Mouse |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
14500851 |
Bcl-2-binding component 3 (p53 up-regulated modulator of apoptosis) [Source:UniProtKB/Swiss-Prot;Acc:Q99ML1] |
|
CD36 |
|
Mouse |
OTHER |
APOPTOSIS |
APOPTOTIC CELL CLEARANCE |
17101731,18073771 |
Platelet glycoprotein 4 (Platelet glycoprotein IV)(GPIV)(GPIIIB)(PAS IV)(PAS-4)(CD36 antigen) [Source:UniProtKB/Swiss-Prot;Acc:Q08857] |
Scavenger receptor which regocnizes oxidized PS on apoptotic cells. |
CALR |
CALREGULIN,CRP55,HACBP,ERP60 |
Mouse |
OTHER |
APOPTOSIS |
APOPTOTIC CELL CLEARANCE |
16239148,10085286 |
Calreticulin Precursor (CRP55)(Calregulin)(HACBP)(ERp60) [Source:UniProtKB/Swiss-Prot;Acc:P14211] |
|
BAX |
BAX, BCL2-ASSOCIATED X PROTEIN |
Mouse |
CARD-CONTAINING PROTEIN;OTHER |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
9560245 |
BCL2-associated X protein Gene [Source:MGI Symbol;Acc:MGI:99702] |
|
BID |
BID, BH3 INTERACTING DOMAIN DEATH AGONIST |
Mouse |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
EXTRINSIC PATHWAY |
10476969 |
BH3 interacting domain death agonist Gene [Source:MGI (curated);Acc:Bid-001] |
|
CASPASE-14 |
CASPASE 14, CASPASE-14, CASP14, MICE, MINI-ICE |
Mouse |
CASPASE |
CELL DEATH (OTHER) |
UNDEFINED |
10203698,17515931 |
murine caspase 14 |
Mice deficient in caspase-14 develop skin problems. This protein is involved in keratinocyte differentiation and cornification, which is a non-apoptotic form of cell death. |
BCL2L1 |
BCL2L1, BCL2-LIKE 1, BCL(X)L, BCL-X, BCL-XL, BCL-XS, BCLX |
Mouse |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
7963517 |
BCL2-like 1 Gene [Source:MGI (curated);Acc:Bcl2l1-001] |
|
TNFRSF22 |
TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 22, 2810028K06RIK, C130035G06RIK, MDCTRAILR2, SOBA, TNFRH2 |
Mouse |
DEATH RECEPTOR |
UNDEFINED |
UNDEFINED |
18079962,12466268,19476510 |
Tumor necrosis factor receptor superfamily member 22 (Tumor necrosis factor receptor p60 homolog 2)(TNF receptor family member SOBa)(Decoy TRAIL receptor 2)(TNF receptor homolog 2) [Source:UniProtKB/Swiss-Prot;Acc:Q9ER62] |
|
GZMB |
GZMB, GRANZYME B,CTLA-1, CTLA1,GRB |
Mouse |
OTHER; |
|
|
8702964,12629051 |
Granzyme B(G,H) Precursor (EC 3.4.21.79)(Cytotoxic cell protease 1)(CCP1)(CTLA-1)(Fragmentin-2) [Source:UniProtKB/Swiss-Prot;Acc:P04187] |
Granzyme B cleaves and activates caspases and Bid to induce apoptosis. |
BIK |
BIK, BCL2-INTERACTING KILLER |
Mouse |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY |
9525867,14749373 |
BCL2-interacting killer [Source:RefSeq peptide;Acc:NP_031572] |
|
BIRC5 |
API4, IAP4, SURVIVIN, TIAP, APOPTOSIS INHIBITOR 4 |
Mouse |
BIR-CONTAINING PROTEIN;OTHER |
CELL DEATH (OTHER) |
|
12145814,11329368 |
Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin)(Apoptosis inhibitor 4)(TIAP) [Source:UniProtKB/Swiss-Prot;Acc:O70201] |
Survivin is a protein with homology to IAPs but whose main role is the regulation of mitosis, not cell death. |
APAF1 |
APAF1, APOPTOTIC PEPTIDASE ACTIVATING FACTOR 1 |
Mouse |
CARD-CONTAINING PROTEIN;CARD ADAPTER PROTEIN |
APOPTOSIS |
INTRINSIC PATHWAY |
9753321 |
apoptotic peptidase activating factor 1 Gene [Source:MGI Symbol;Acc:MGI:1306796] |
|
RIPK1 |
|
Mouse |
DEATH DOMAIN-CONTAINING PROTEIN;OTHER |
NECROPTOSIS |
TNF/NF-KAPPAB SIGNALING |
19632174,12654725 |
receptor (TNFRSF)-interacting serine-threonine kinase 1 Gene [Source:MGI Symbol;Acc:MGI:108212] |
|
BNIP3L |
BNIP3L, BCL2/ADENOVIRUS E1B INTERACTING PROTEIN 3-LIKE |
Mouse |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY |
9396766 |
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (NIP3-like protein X)(NIP3L) [Source:UniProtKB/Swiss-Prot;Acc:Q9Z2F7] |
|
TNFRSF10B |
TNFRSF10B, TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B, DR5, KILLER, KILLER/DR5, LY98, TRAIL RECEPTOR, TRAIL-R2, TRAILR2, TRICK2A, TRICK2B, TRICKB |
Mouse |
DEATH RECEPTOR |
APOPTOSIS |
EXTRINSIC PATHWAY |
18079962,10383128,15713653 |
Tumor necrosis factor receptor superfamily member 10B Precursor (Death receptor 5)(MK)(CD262 antigen) [Source:UniProtKB/Swiss-Prot;Acc:Q9QZM4] |
homolog of human TRAIL-R2
|
BCL2L2 |
BCL-W, BCLW, GTRGAL2, GTROSA41,BCL2L2, BCL2-LIKE 2 |
Mouse |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
9500547,9770502 |
BCL2-like 2 Gene [Source:MGI Symbol;Acc:MGI:108052] |
|
RIPK3 |
RIPK3, RECEPTOR-INTERACTING SERINE-THREONINE KINASE 3 |
Mouse |
OTHER |
NECROPTOSIS |
TNF/NF-KAPPAB SIGNALING |
19524512,19524513 |
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1)(RIP-like protein kinase 3)(Receptor-interacting protein 3)(RIP-3)(mRIP3) [Source:UniProtKB/Swiss-Prot;Acc:Q9QZL0] |
|
TNF |
TNF, TUMOR NECROSIS FACTOR, DIF, TNF ALPHA, TNF-ALPHA, TNFA, TNFALPHA, TNFSF1A, TUMOR NECROSIS FACTOR-ALPHA |
Mouse |
DEATH LIGAND |
APOPTOSIS |
EXTRINSIC PATHWAY |
2993897 |
Tumor necrosis factor Precursor (TNF-alpha)(Tumor necrosis factor ligand superfamily member 2)(TNF-a)(Cachectin) [Contains Tumor necrosis factor, membrane form;Tumor necrosis factor, soluble form] [Source:UniProtKB/Swiss-Prot;Acc:P06804] |
|
PMAIP1 |
NOXA, PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1 |
Mouse |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
10807576 |
Phorbol-12-myristate-13-acetate-induced protein 1 (Noxa) [Source:UniProtKB/Swiss-Prot;Acc:Q9JM54] |
|
ANXA1 |
ANX1, LPC-1, LPC1, ANNEXIN A1, LIPOCORTIN I |
Mouse |
OTHER; |
APOPTOSIS |
APOPTOTIC CELL CLEARANCE |
12516535,18073771 |
Annexin A1 (Annexin-1)(Annexin I)(Lipocortin I)(Calpactin II)(Chromobindin-9)(p35)(Phospholipase A2 inhibitory protein) [Source:UniProtKB/Swiss-Prot;Acc:P10107] |
|
FAS |
FAS, FAS (TNF RECEPTOR SUPERFAMILY MEMBER 6) |
Mouse |
DEATH RECEPTOR |
APOPTOSIS |
EXTRINSIC PATHWAY |
1372394 |
Tumor necrosis factor receptor superfamily member 6 Precursor (FASLG receptor)(Apoptosis-mediating surface antigen FAS)(Apo-1 antigen)(CD95 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P25446] |
|
BAD |
BBC6, BCL2-ASSOCIATED AGONIST OF CELL DEATH |
Mouse |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY |
9372935 |
BCL2-associated agonist of cell death Gene [Source:MGI (curated);Acc:Bad-001] |
|
CASP7 |
CASPASE 7, CASPASE-7, CMH-1, ICE-IAP3, MCH3 |
Mouse |
CASPASE |
APOPTOSIS |
EXTRINSIC PATHWAY,INTRINSIC PATHWAY,POST-MITOCHONDRIAL CASPASE ACTIVATION |
9070923 |
caspase 7 Gene [Source:MGI Symbol;Acc:MGI:109383] |
|
LRDD |
PIDD, LRDD, LEUCINE-RICH AND DEATH DOMAIN CONTAINING, 1200011D09RIK |
Mouse |
DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN |
|
|
10973264,19364921 |
Leucine-rich repeat and death domain-containing protein [Source:UniProtKB/Swiss-Prot;Acc:Q9ERV7] |
|
XIAP |
X-LINKED INHIBITOR OF APOPTOSIS, 1110015C02RIK, AIPA, API3, BIRC4, IAP3, ILP-1 |
Mouse |
BIR-CONTAINING PROTEIN;IAP |
APOPTOSIS |
INTRINSIC PATHWAY,EXTRINSIC PATHWAY |
11313486,9990849,19626005 |
Baculoviral IAP repeat-containing protein 4 (EC 6.3.2.-)(E3 ubiquitin-protein ligase XIAP)(Inhibitor of apoptosis protein 3)(X-linked inhibitor of apoptosis protein)(X-linked IAP)(IAP homolog A)(MIAP-3)(MIAP3) [Source:UniProtKB/Swiss-Prot;Acc:Q60989] |
|
CASP12 |
CASP12, CASPASE 12 |
Mouse |
CASPASE |
IMMUNITY |
INFLAMMASOME |
16625199 |
caspase 12 Gene [Source:MGI Symbol;Acc:MGI:1312922] |
|
CASP1 |
CASPASE 1, CASPASE-1, ICE, IL1BC, INTERLEUKIN 1 BETA-CONVERTING ENZYME |
Mouse |
CASPASE |
IMMUNITY |
INFLAMMASOME |
9015751 |
caspase 1 Gene [Source:MGI Symbol;Acc:MGI:96544] |
|
CASP8 |
CASPASE 8, CASPASE-8, FLICE, MACH, MCH5 |
Mouse |
CASPASE |
APOPTOSIS |
EXTRINSIC PATHWAY |
9729047 |
caspase 8 Gene [Source:MGI Symbol;Acc:MGI:1261423] |
|
CFLAR |
CASP8 AND FADD-LIKE APOPTOSIS REGULATOR, 2310024N18RIK, A430105C05RIK, C-FLIP, CASH, CASPER, FLIP |
Mouse |
CASPASE,DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN;OTHER |
APOPTOSIS |
EXTRINSIC PATHWAY |
10894163 |
CASP8 and FADD-like apoptosis regulator Precursor (Cellular FLICE-like inhibitory protein)(c-FLIP)(Caspase-eight-related protein)(Casper)(Caspase-like apoptosis regulatory protein)(CLARP)(MACH-related inducer of toxicity)(MRIT)(Caspase homolog)(CASH)(Inhibitor of FLICE)(I-FLICE)(FADD-like antiapoptotic molecule 1)(FLAME-1)(Usurpin) [Contains CASP8 and FADD-like apoptosis regulator subunit p43;CASP8 and FADD-like apoptosis regulator subunit p12] [Source:UniProtKB/Swiss-Prot;Acc:O35732] |
|
BOK |
BOK, BCL2-RELATED OVARIAN KILLER PROTEIN |
Mouse |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
|
|
9535847 |
BCL2-related ovarian killer protein Gene [Source:MGI Symbol;Acc:MGI:1858494] |
|
PARP1 |
PARP1, POLY (ADP-RIBOSE) POLYMERASE FAMILY, MEMBER 1 |
Mouse |
OTHER |
CELL DEATH (OTHER) |
|
15145826 |
Poly [ADP-ribose] polymerase 1 (PARP-1)(EC 2.4.2.30)(ADPRT)(NAD(+) ADP-ribosyltransferase 1)(Poly[ADP-ribose] synthetase 1)(msPARP) [Source:UniProtKB/Swiss-Prot;Acc:P11103] |
|
BCL2L11 |
BCL2L11, BCL2-LIKE 11 (APOPTOSIS FACILITATOR), 1500006F24RIK, BIM, BOD |
Mouse |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
9430630,19641506 |
BCL2-like 11 (apoptosis facilitator) Gene [Source:MGI (curated);Acc:Bcl2l11-001] |
|
CASP6 |
CASPASE 6, MCASP-6, MCH2 |
Mouse |
CASPASE |
|
|
19225519,18981099 |
caspase 6 Gene [Source:MGI (curated);Acc:Casp6-001] |
|
TNFRSF1B |
TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B, CD120B, P75, P75 TNFR, TNF-ALPHAR2, TNF-R-II, TNF-R2, TNF-R75, TNFALPHA-R2, TNFBR, TNFR-1, TNFR2, TNFR80, TNFRII |
Mouse |
DEATH RECEPTOR |
APOPTOSIS,NECROPTOSIS |
EXTRINSIC PATHWAY,TNF/NF-KAPPAB SIGNALING |
1645445,14532286 |
Tumor necrosis factor receptor superfamily member 1B Precursor (Tumor necrosis factor receptor 2)(TNF-R2)(Tumor necrosis factor receptor type II)(p75)(p80 TNF-alpha receptor)(CD120b antigen) [Source:UniProtKB/Swiss-Prot;Acc:P25119] |
|
CASP9 |
CASPASE 9, CASPASE-9, ICE-LAP6, MCH6 |
Mouse |
CASPASE |
APOPTOSIS |
INTRINSIC PATHWAY,POST-MITOCHONDRIAL CASPASE ACTIVATION |
9708735,9708736 |
caspase 9 [Source:RefSeq peptide;Acc:NP_056548] |
|
DIABLO |
DIABLO HOMOLOG (DROSOPHILA), 0610041G12RIK, 1700006L01RIK, SMAC |
Mouse |
IAP ANTAGONIST |
|
|
11971981 |
Diablo homolog, mitochondrial Precursor (Second mitochondria-derived activator of caspase)(Smac protein)(Direct IAP-binding protein with low pI) [Source:UniProtKB/Swiss-Prot;Acc:Q9JIQ3] |
|
CASP2 |
CASPASE 2, CASPASE-2, ICH-1, NEDD2 |
Mouse |
CASPASE |
APOPTOSIS |
|
7958843,19581929 |
caspase 2 Gene [Source:MGI (curated);Acc:Casp2-001] |
The role of caspase-2 during apoptosis is still under debate |
TNFRSF1A |
TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A, CD120A, P55, P55-R, TNF RECEPTOR ALPHA CHAIN, TNF-ALPHA-R1, TNF-ALPHAR1, TNF-R-I, TNF-R1, TNF-R55, TNFALPHA-R1, TNFAR, TNFR-2, TNFR1, TNFR60, TNFRI, TNFRP55 |
Mouse |
DEATH RECEPTOR |
APOPTOSIS,NECROPTOSIS |
EXTRINSIC PATHWAY,TNF/NF-KAPPAB SIGNALING |
1645445,1718003 |
Tumor necrosis factor receptor superfamily member 1A Precursor (p60)(TNF-R1)(TNF-RI)(TNFR-I)(p55)(CD120a antigen) [Source:UniProtKB/Swiss-Prot;Acc:P25118] |
|
FADD |
FADD, FAS (TNFRSF6)-ASSOCIATED VIA DEATH DOMAIN |
Mouse |
DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN,DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN;DED ADAPTER PROTEIN |
APOPTOSIS |
EXTRINSIC PATHWAY |
9521326 |
Protein FADD (FAS-associated death domain protein)(FAS-associating death domain-containing protein)(Mediator of receptor induced toxicity) [Source:UniProtKB/Swiss-Prot;Acc:Q61160] |
|
CASP3 |
CASPASE 3, A830040C14RIK, APOPAIN, CASPASE-3, CC3, CPP32, YAMA |
Mouse |
CASPASE |
APOPTOSIS |
EXTRINSIC PATHWAY,INTRINSIC PATHWAY,POST-MITOCHONDRIAL CASPASE ACTIVATION |
8934524 |
caspase 3 Gene [Source:MGI Symbol;Acc:MGI:107739] |
|
TRADD |
TRADD, TNFRSF1A-ASSOCIATED VIA DEATH DOMAIN |
Mouse |
DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN |
APOPTOSIS |
EXTRINSIC PATHWAY,TNF/NF-KAPPAB SIGNALING |
7758105 |
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein)(TNFRSF1A-associated via death domain) [Source:UniProtKB/Swiss-Prot;Acc:Q3U0V2] |
|
CIAP2 |
BIRC3, API2, CIAP-2, CIAP2, HIAP2, IAP2, MIAP2, MIHC, RNF49 |
Mouse |
BIR-CONTAINING PROTEIN;IAP |
IMMUNITY |
TNF/NF-KAPPAB SIGNALING |
19464198,8548810 |
baculoviral IAP repeat-containing 3 Gene |
|
BCL2L10 |
BCL2L10, BCL2-LIKE 10, BOO, DIVA |
Mouse |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
UNDEFINED |
UNDEFINED |
9878060,12215543 |
Bcl2-like 10 Gene [Source:MGI Symbol;Acc:MGI:1330841] |
The role of this protein during cell death requires further clarification. |
NLRP3 |
NLRP3, NLR FAMILY, PYRIN DOMAIN CONTAINING 3 |
Mouse |
OTHER |
IMMUNITY |
INFLAMMASOME |
12563287,15952891 |
NACHT, LRR and PYD domains-containing protein 3 (Cold autoinflammatory syndrome 1 protein homolog)(Cryopyrin)(PYRIN-containing APAF1-like protein 1)(Mast cell maturation-associated-inducible protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q8R4B8] |
|
CASP4 |
CASPASE 4, CASP11, CASPASE-11, ICH-3 |
Mouse |
CASPASE |
IMMUNITY |
INFLAMMASOME |
9491891 |
caspase 4, apoptosis-related cysteine peptidase Gene [Source:MGI Symbol;Acc:MGI:107700] |
|
PARP2 |
PARP2, POLY (ADP-RIBOSE) POLYMERASE FAMILY, MEMBER 2 |
Mouse |
OTHER |
NECROPTOSIS |
|
10364231,19109899 |
poly (ADP-ribose) polymerase family, member 2 Gene [Source:MGI Symbol;Acc:MGI:1341112] |
|
CYLD |
CYLD, CYLINDROMATOSIS (TURBAN TUMOR SYNDROME) |
Mouse |
OTHER |
NECROPTOSIS |
TNF/NF-KAPPAB SIGNALING |
19109899 |
cylindromatosis (turban tumor syndrome) Gene [Source:MGI Symbol;Acc:MGI:1921506] |
|
AIFM1 |
AIFM1, APOPTOSIS-INDUCING FACTOR, MITOCHONDRION-ASSOCIATED 1, AIF, PDCD8 |
Mouse |
OTHER |
CELL DEATH (OTHER) |
|
16788063,15526035 |
apoptosis-inducing factor, mitochondrion-associated 1 Gene [Source:MGI (curated);Acc:Aifm1-001] |
|
TNFRSF23 |
TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 23, MDCTRAILR1, MSOB, TNFRH1 |
Mouse |
DEATH RECEPTOR |
UNDEFINED |
UNDEFINED |
18079962,10383128,12466268,19476510 |
Tumor necrosis factor receptor superfamily member 23 Precursor (Tumor necrosis factor receptor p60 homolog 1)(TNF receptor family member SOB)(Decoy TRAIL receptor 1)(TNF receptor homolog 1) [Source:UniProtKB/Swiss-Prot;Acc:Q9ER63] |
|
MCL1 |
MCL1, MYELOID CELL LEUKEMIA SEQUENCE 1 |
Mouse |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
9002967,19127517 |
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Bcl-2-related protein EAT/mcl1) [Source:UniProtKB/Swiss-Prot;Acc:P97287] |
|
TRAIL |
TNFSF10, TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY MEMBER 10, APO-2L, TRAIL |
Mouse |
DEATH LIGAND |
APOPTOSIS |
EXTRINSIC PATHWAY |
12209637 |
Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand)(Protein TRAIL)(CD253 antigen) |
|
BMF |
BMF, BCL2 MODIFYING FACTOR |
Mouse |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS,NECROPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
19109899,11546872 |
BCL2 modifying factor Gene [Source:MGI (curated);Acc:Bmf-001] |
|
DP5 |
HRK, HARAKIRI, BCL2 INTERACTING PROTEIN (CONTAINS ONLY BH3 DOMAIN) |
Mouse |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
17535852,9130713 |
Activator of apoptosis harakiri (Neuronal death protein DP5)(BH3-interacting domain-containing protein 3) [Source:UniProtKB/Swiss-Prot;Acc:P62816] |
|
BCL2 |
BCL2, B-CELL LEUKEMIA/LYMPHOMA 2 |
Mouse |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
3032455 |
B-cell leukemia/lymphoma 2 Gene [Source:MGI (curated);Acc:Bcl2-001] |
|
CIAP1 |
BIRC2, API1, CIAP-1, CIAP1, HIAP1, IAP1, MCIAP1, MIAP1, MIHB, BIRC2, BACULOVIRAL IAP REPEAT-CONTAINING 2 |
Mouse |
BIR-CONTAINING PROTEIN;IAP |
IMMUNITY |
TNF/NF-KAPPAB SIGNALING |
19464198,8548810 |
baculoviral IAP repeat-containing 2 Gene |
|
BAK1 |
BCL2-ANTAGONIST/KILLER 1, BAK, N-BAK |
Mouse |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
11326099,9299236 |
BCL2-antagonist/killer 1 Gene [Source:MGI (curated);Acc:Bak1-001] |
|
TRP53 |
TP53, P53, TUMOR SUPPRESSOR P53, TRP53, CELLULAR TUMOR ANTIGEN P53 |
Mouse |
OTHER |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
19410540,8353276 |
transformation related protein 53 Gene [Source:MGI (curated);Acc:Trp53-001] |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. |
CYCS |
CYCS, CYTOCHROME C, SOMATIC |
Mouse |
OTHER |
APOPTOSIS |
EXTRINSIC PATHWAY,INTRINSIC PATHWAY,POST-MITOCHONDRIAL CASPASE ACTIVATION |
15907471 |
Cytochrome c, somatic [Source:UniProtKB/Swiss-Prot;Acc:P62897] |
|
NLRP1A |
NLRP1A, NLR FAMILY, PYRIN DOMAIN CONTAINING 1A |
Mouse |
CARD-CONTAINING PROTEIN;CARD ADAPTER PROTEIN |
IMMUNITY |
INFLAMMASOME |
12563287,15952891 |
NLR family, pyrin domain containing 1A [Source:RefSeq peptide;Acc:NP_001004142] |
|
BCL2A1A |
BCL2A1A, B-CELL LEUKEMIA/LYMPHOMA 2 RELATED PROTEIN A1A, A1, BCL2A1, BFL-1, HBPA1 |
Mouse |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS |
8345191 |
Bcl-2-related protein A1 (Protein BFL-1)(Hemopoietic-specific early response protein)(A1-A) [Source:UniProtKB/Swiss-Prot;Acc:Q07440] |
|
BNIP3 |
BNIP3, BCL2/ADENOVIRUS E1B INTERACTING PROTEIN 3 |
Mouse |
BCL-2 FAMILY;BH3-ONLY |
CELL DEATH (OTHER),APOPTOSIS |
INTRINSIC PATHWAY |
19641497,9575197 |
BCL2/adenovirus E1B interacting protein 3 Gene [Source:MGI (curated);Acc:Bnip3-001] |
|
CED-8 |
|
Worm |
OTHER |
APOPTOSIS |
|
10882128 |
The ced-8 gene encodes a homolog of the human putative membrane transporter XK. ced-8 is required for apoptosis to occur with normal speed during embryonic development. [Source: WormBase] |
|
EGL-1 |
|
Worm |
BCL-2 FAMILY;BH3-ONLY |
APOPTOSIS |
|
9604928 |
egl-1 encodes a novel protein that contains a region similar to the BH3 (Bcl-2 homology region 3) domain of mammalian cell death activators. EGL-1 functions as an upstream activator in the general programmed cell death pathway and positively regulates programmed cell death by interacting directly with CED-9 to induce CED-4 release from CED-4/CED-9 complexes and ultimately activate the CED-3 caspase. EGL-1 also induces WAH-1/apoptosis-inducing factor release from the mitochondria. in hermaphrodites, egl-1 is transcriptionally repressed by TRA-1, permitting survival of the HSN neurons required for egg laying. egl-1 message is detected at low abundance in embryonic and L1 larval mRNA preparations, but not in mRNA preparations from later larval stages or young adults. [Source: WormBase] |
|
CEP-1 |
TRANSCRIPTION FACTOR CEP-1, C.ELEGANS P53-LIKE PROTEIN 1 |
Worm |
OTHER |
UNDEFINED |
UNDEFINED |
11557844,11696333 |
Ancestral member of the p53 family (p53, p63, p73) |
Promotes DNA damage-induced apoptosis and is required for normal meiotic segregation in the C. elegans germ line. Affects sensitivity to hypoxia-induced lethality and longevity in response to starvation. Implicated in autophagy. Expressed in the germ line and during embryogenesis. |
BSK |
JNK, STRESS-ACTIVATED PROTEIN KINASE JNK |
Fly |
OTHER |
CELL DEATH (OTHER) |
|
8946915,10408443 |
NA |
|
TH |
IAP1,INHIBITOR OF APOPTOSIS 1, THREAD |
Fly |
BIR-CONTAINING PROTEIN;IAP |
APOPTOSIS |
|
8548811 |
NA |
|
W |
CELL DEATH PROTEIN W, PROTEIN HEAD INVOLUTION DEFECTIVE, PROTEIN WRINKLED, HID |
Fly |
IAP ANTAGONIST |
APOPTOSIS |
|
7622034 |
NA |
|
CRC |
CALRETICULIN |
Fly |
OTHER; |
APOPTOSIS |
APOPTOTIC CELL CLEARANCE |
17137576,19291407 |
Calreticulin |
|
DCP-1 |
CASPASE-1, CASPASE-1 SUBUNIT P22, CASPASE-1 SUBUNIT P13 |
Fly |
CASPASE |
APOPTOSIS |
|
8999799 |
NA |
|
ATG1 |
|
Fly |
OTHER; |
CELL DEATH (OTHER) |
|
19818615,18083103 |
Autophagy-specific gene 1 |
This protein participates in autophagic cell death during Drosophila development. |
RPR |
CELL DEATH PROTEIN RPR, REAPER |
Fly |
IAP ANTAGONIST |
APOPTOSIS |
|
8171319 |
NA |
|
IMD |
IMMUNE DEFICIENCY, BG5 |
Fly |
DEATH DOMAIN-CONTAINING PROTEIN;OTHER |
IMMUNITY |
|
1132328 |
NA |
|
IAP2 |
APOPTOSIS 2 INHIBITOR, INHIBITOR OF APOPTOSIS 2, DIAP2, DIAP, IAP HOMOLOG A, DIHA, ILP |
Fly |
BIR-CONTAINING PROTEIN;IAP |
IMMUNITY,APOPTOSIS |
|
16894030,18166655 |
NA |
|
GRIM |
|
Fly |
IAP ANTAGONIST |
APOPTOSIS |
|
8698237 |
NA |
|
ICE |
DRICE, CASPASE SUBUNIT P21, CASPASE SUBUNIT P12 |
Fly |
CASPASE |
APOPTOSIS |
|
9184225 |
NA |
|
DREDD |
CASPASE-8, CASPASE-8 SUBUNIT P15, CASPASE-8 SUBUNIT P10, DCP2 |
Fly |
CASPASE |
IMMUNITY |
TNF/NF-KAPPAB SIGNALING |
9740659 |
NA |
|
ARK |
APAF-1 RELATED KILLER DARK, APAF-1/CED-4-RELATED CASPASE ACTIVATOR DAPAF-1L, CELL DEATH PROTEIN HAC-1, HAC1, DAPAF-1L |
Fly |
CARD-CONTAINING PROTEIN;CARD ADAPTER PROTEIN |
APOPTOSIS |
|
10559939 |
NA |
|
TRAF2 |
TNF-RECEPTOR-ASSOCIATED FACTOR 6, TRAF6 |
Fly |
OTHER |
CELL DEATH (OTHER) |
TNF/NF-KAPPAB SIGNALING |
12894227 |
NA |
|
TRAF1 |
TNF-RECEPTOR-ASSOCIATED FACTOR 4, TRAF4 |
Fly |
OTHER |
CELL DEATH (OTHER) |
TNF/NF-KAPPAB SIGNALING |
10766844,12198495 |
NA |
|
NC |
DRONC, CASPASE NC, NEDD2-LIKE CASPASE DRONC, CASPASE NC SUBUNIT 1, CASPASE NC SUBUNIT 2 |
Fly |
CASPASE |
APOPTOSIS |
|
10200258,10675329 |
NA |
|
DRPR |
DRAPER |
Fly |
OTHER |
APOPTOSIS |
APOPTOTIC CELL CLEARANCE |
15342648,16772169,19291407 |
draper |
|
DECAY |
DEATH EXECUTIONER CASPASE RELATED TO APOPAIN/YAMA, CASPASE 6-LIKE PROTEIN BG2 |
Fly |
CASPASE |
APOPTOSIS |
|
10521468,16485033 |
NA |
|
DEBCL |
|
Fly |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
CELL DEATH (OTHER) |
|
10684252,19088092 |
NA |
|
WGN |
WENGEN, TNFR SUPERFAMILY PROTEIN WENGEN, VADER |
Fly |
DEATH RECEPTOR |
CELL DEATH (OTHER) |
TNF/NF-KAPPAB SIGNALING |
12084706 |
NA |
|
DREAM |
STRICA |
Fly |
CASPASE |
APOPTOSIS |
|
11550090,16485033 |
NA |
|
EGR |
EIGER |
Fly |
DEATH LIGAND |
CELL DEATH (OTHER) |
TNF/NF-KAPPAB SIGNALING |
12065414 |
NA |
|
DAMM |
DEATH ASSOCIATED MOLECULE RELATED TO MCH2, DAYDREAM |
Fly |
CASPASE |
|
|
11337486 |
NA |
Ectopic expression of DAMM induces apoptosis [Pubmed Link: 11337486] |
HIPK |
HIPK, HOMEODOMAIN INTERACTING PROTEIN KINASE |
Fly |
OTHER |
CELL DEATH (OTHER) |
|
17682052 |
NA |
|
ATG18 |
|
Fly |
OTHER; |
CELL DEATH (OTHER) |
|
19818615,18083103 |
Autophagy-specific gene 18 |
This protein participates in autophagic cell death during Drosophila development. |
ARD1 |
ARREST DEFECTIVE 1 |
Fly |
OTHER |
APOPTOSIS |
|
17998402 |
NA |
|
SKL |
SICKLE, IAP-INHIBITORY PROTEIN SICKLE |
Fly |
IAP ANTAGONIST |
APOPTOSIS |
|
11818063 |
NA |
|
BRUCE |
BIR-CONTAINING UBIQUITIN-CONJUGATING ENZYME |
Fly |
BIR-CONTAINING PROTEIN;IAP |
CELL DEATH (OTHER) |
|
12121627 |
NA |
|
HTRA2 |
OMI, SERINE PROTEASE HTRA2 |
Fly |
OTHER |
APOPTOSIS |
|
17557079,17397804 |
NA |
|
BG4 |
DEATH DOMAIN-CONTAINING ADAPTER PROTEIN BG4, FAS-ASSOCIATED DEATH DOMAIN-CONTAINING PROTEIN |
Fly |
DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN |
IMMUNITY |
TNF/NF-KAPPAB SIGNALING |
10934188,12433364,12123572 |
NA |
|
JAFRAC2 |
THIOREDOXIN PEROXIDASE 2, GH25379P, SECRETABLE THIOREDOXIN PEROXIDASE |
Fly |
IAP ANTAGONIST |
APOPTOSIS |
|
12356728 |
NA |
|
BUFFY |
|
Fly |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
|
12853472 |
NA |
|
ATG2 |
|
Fly |
OTHER; |
CELL DEATH (OTHER) |
|
19818615,18083103 |
Autophagy-specific gene 2 |
This protein participates in autophagic cell death during Drosophila development. |
ATG8A |
|
Fly |
OTHER; |
CELL DEATH (OTHER) |
|
18083103 |
Autophagy-specific gene 8a |
This protein participates in autophagic cell death during Drosophila development. |
CYT-C-D |
CYTOCHROME C-1, CYTOCHROME C-DISTAL, CYTC1, DC3 |
Fly |
OTHER |
|
|
18451868,12737804,10037791 |
NA |
The role of cytochrome c on apoptosis in Drosophila is still unclear since there is not a classical mitochondrial pathway. However, cyt.c seems to participate in apoptosis of some cell types [Pubmed Link: 12737804] |
CED-9 |
|
Worm |
BCL-2 FAMILY;MULTIDOMAIN BCL-2 |
APOPTOSIS |
|
1560823 |
ced-9 encodes the sole C. elegans homolog of the mammalian cell-death inhibitor Bcl-2. during development, CED-9 activity is essential for preventing cells from undergoing programmed cell death and CED-9 functions by binding and repressing the activity of CED-4, a protein similar to human APAF-1 that positively regulates CED-3 caspase activity. CED-9 localizes to mitochondria. [Source: WormBase] |
|
CED-1 |
|
Worm |
OTHER; |
APOPTOSIS |
APOPTOTIC CELL CLEARANCE |
11163239,15642378 |
The ced-1 gene encodes a transmembrane protein on phagocytic cells that is homologous to human CD91, a low density lipoprotein receptor paralog. the cytoplasmic tail of CED-1 contains two motifs important for engulfment. [Source: WormBase] |
CED-1 is a transmembrane receptor, similar to CD91/LRP scavenger receptors. |
CSP-3 |
|
Worm |
CASPASE |
APOPTOSIS |
|
18776901 |
csp-3 encodes a protein that is homologous to the C-terminal domain of caspase-like cysteine proteases. unlike other caspases, CSP-3 does not contain a middle or N-terminal domain, and thus may either function in concert with the middle domains of other caspases or may play a regulatory (dominant negative) role in caspase activation. [Source: WormBase] |
This protein is highly homologous to Ced-3 and can inhibit its autoactivation |
WAH-1 |
|
Worm |
OTHER |
APOPTOSIS |
|
12446902 |
wah-1 encodes a putative flavin-adenine dinucleotide (FAD)-binding oxidoreductase orthologous to mammalian PDCD8 (AIF. OMIM:300169, mutated in Harlequin mice). WAH-1 is required for apoptotic DNA degratation, SCRM-1 phospholipid scramblase activity, phosphatidylserine exposure, rapid apoptosis during embryonic development, and rapid engulfment of apoptotic cells in the germline. WAH-1 is also required for normally rapid growth and large brood sizes, and has a subtle proapoptotic function revealed in ced-3 or ced-4 mutant backgrounds. WAH-1 is expressed in most, if not all, cells of embryos and larvae. WAH-1 is normally mitochondrial, but can be released into the cytosol and nucleus by EGL-1 and CED-3. residues 380-550 of WAH-1 specifically bind SCRM-1 in vitro, but not SCRM-2 through SCRM-4, and WAH-1 binding is required in liposomes for more than residual SCRM-1 activity. WAH-1 also binds and activates CPS-6, promoting apoptotic DNA degradation, and transgenic coexpression of WAH-1 with CPS-6 specifically induces ectopic CED-3-dependent apoptosis in touch receptor neurons. CPS-6 shares a genetic pathway with WAH-1, whereas CED-3, CED-4, CED-8, and NUC-1 act independently of it. WAH-1 is paralogous to C. elegans F20D6.11 and human AIFM3 (AIFL). [Source: WormBase] |
|
NEX-1 |
|
Worm |
OTHER; |
APOPTOSIS |
APOPTOTIC CELL CLEARANCE |
12689596,15642378 |
nex-1 encodes an annexin, a member of a family of calcium-dependent phospholipid binding proteins. NEX-1 is required for efficient engulfment of apoptotic cell corpses in the pharynx, and may also function in other membrane fusion events, such as exocytosis. NEX-1 in vitro can bind phosphatidylserine, phosphatidylinositol, heparin, heparan sulfate, and chondroitin sulfate. NEX-1 is expressed in the pharynx, hypodermal cells, the vulva, the uterus, the spermathecal valve, and yolk granules of maturing oocytes. [Source: WormBase] |
|