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NameSynonymsSpeciesFamilyProcessPathwayRefsDescriptionComments
DCT-1 Worm BCL-2 FAMILY;BH3-ONLY APOPTOSIS 9824163 dct-1 encodes a protein with similarity to the mammalian BNIP3 proteins that interact with Bcl-2 and the Adenovirus E1B 19kDa protein and that have been shown to have pro-apoptotic activity. loss of dct-1 activity via RNAi in daf-2 mutants and in gld-1. daf-2 doubly mutant animals indicates that dct-1 can function to regulate both lifespan and tumor cell proliferation. when expressed in mammalian cells, DCT-1 can: 1) induce delayed apoptosis and increase apoptosis when coexpressed with CED-3 (perhaps by increasing proteolyic processing of CED-3), 2) physically interact with CED-9 or the CED-3 prodomain when coexpressed, and 3) physically interact with both CED-9 and CED-3 when all three are coexpressed. chromatin immunoprecipitation experiments have demonstrated that the dct-1 promoter is bound in vivo by the forkhead transcription factor DAF-16. expression of DCT-1 in mammalian cells suggests that, like its mammalian orthologs, DCT-1 localizes to mitochondria via a predicted C-terminal transmembrane domain. [Source: WormBase]
CED-4 Worm CARD-CONTAINING PROTEIN;CARD ADAPTER PROTEIN APOPTOSIS 9109415 ced-4 encodes a novel protein. along with CED-3, CED-4 is required for the initiation of programmed cell death. accordingly, genetic analyses indicate that ced-3 and ced-4 function upstream of ced-1, ced-2, and nuc-1 in the programmed cell death pathway. in yeast two-hybrid experiments, and upon coexpression in mammalian cells, CED-4 interacts with CED-9, an anti-apoptotic BCL-2 homolog. coexpression of CED-4 and CED-9 results in redistribution of CED-4 from the cytosol to organellar membranes, suggesting that CED-9 may negatively regulate CED-4 activity by sequestering CED-4 to intracellular membranes. [Source: WormBase]
CED-3 Worm CASPASE APOPTOSIS 8654923 The ced-3 gene encodes a protease required for apoptosis. [Source: WormBase]
TNFRSF21 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21, DR6, IM:6795346, WU:FA55E01, WU:FB02E11, WU:FC29A09, WU:FI27H08 Zebrafish DEATH RECEPTOR UNDEFINED EXTRINSIC PATHWAY 16888647 tumor necrosis factor receptor superfamily, member 21 [Source:RefSeq_peptide;Acc:NP_001036153] Expression detected in regions of the developing zebrafish central nervous system [16888647] .
TNFSF10L TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY MEMBER 10 LIKE, TRAIL-LIKE, FC12F06, WU:FC12F06, DL1A, DR_TRAIL-LIKE V2 Zebrafish DEATH LIGAND APOPTOSIS EXTRINSIC PATHWAY 16888647,17548633 tumor necrosis factor (ligand) superfamily, member 10 like [Source:RefSeq_peptide;Acc:NP_571918] Ectopic expression of Tnfsf10l in zebrafish embryos induces apoptosis in the notochord [16888647] . Tnfsf10l directly associates with the zebrafish death receptor Tnfrsfa [16888647] . Tnfsf10l-induced apoptosis can be blocked by ectopic expression of zebrafish Cflar or by knockdown of endogenous Tnfrsfa or FADD [16888647] . Zebrafish Tnfsf10l is more structurally related to Apo2L-like (a second copy of Apo2L/TRAIL found in avian species but not mammals) than to mammalian Apo2L/TRAIL due to additional cysteine residues in its extracellular domain 16888647 .
HDR HEMATOPOIETIC DEATH RECEPTOR, ZGC:103531, ZH-DR, MGC103531 Zebrafish DEATH RECEPTOR APOPTOSIS EXTRINSIC PATHWAY 16888647,10934476,16413388 hematopoietic death receptor [Source:RefSeq_peptide;Acc:NP_919372] Ectopic expression of HDR in zebrafish embryos and human cell lines induces apoptosis [16888647]. HDR directly associates with the zebrafish Apo2L/TRAIL orthologs tnfsf10l and tnfsf10l3 [16888647]. Inhibition of HDR in zebrafish embryos and adult fish leads to an accumulation of red blood cells [10934476],[16413388].
TNFRSFA TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER A, OTR, WU:FC27C09, TNF, OVARIAN TNF RECEPTOR Zebrafish DEATH RECEPTOR APOPTOSIS EXTRINSIC PATHWAY 16888647,11399482 tumor necrosis factor receptor superfamily, member a [Source:RefSeq_peptide;Acc:NP_571915] Ectopic expression of Tnfrsfa in zebrafish embryos and human cell lines induces apoptosis [16888647] . Tnfrsfa directly associates with the zebrafish Apo2L/TRAIL orthologs Tnfsf10l and Tnfsf10l2 [16888647] .
MCL1B MYELOID CELL LEUKEMIA SEQUENCE 1B, ZGC:109763 Zebrafish BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 16888646 myeloid cell leukemia sequence 1b [Source:RefSeq_peptide;Acc:NP_919375] Ectopic expression of Mcl1b in zebrafish embryos inhibits apoptosis induced by several pro-apoptotic Bcl2 family members [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ] and gamma-irradiation [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ]. Simultaneous knockdown of both Mcl1a and Mcl1b in zebrafish embryos using antisense morpholino oligonucleotides significantly decreases viability and increases sensitivity to apoptosis induced by the Apo2L/TRAIL ortholog Tnfsf10l3 [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ].
BCL2L ZFBLP1, BCL-XL, CB1021, BCL2-LIKE Zebrafish BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 16888647,11406282,16888646 bcl2-like [Source:RefSeq_peptide;Acc:NP_571882] Ectopic expression of Bcl2l in zebrafish embryos inhibits apoptosis induced by multiple stimuli including death receptor signaling [16888647], ectopic expression of several pro-apoptotic Bcl2 family members [16888646], and gamma-irradiation [16888646].
BOKB BCL2-RELATED OVARIAN KILLER B, ZBOK2, ZGC:64041 Zebrafish BCL-2 FAMILY;MULTIDOMAIN BCL-2 UNDEFINED INTRINSIC PATHWAY 16888646 Bcl-2-related ovarian killer protein homolog B (zBok2). [Source:UniProtKB/Swiss-Prot;Acc:Q7T381]
TNFA TUMOR NECROSIS FACTOR A (TNF SUPERFAMILY MEMBER 2), TNF-ALPHA, TNFA, TNF1 Zebrafish DEATH LIGAND UNDEFINED EXTRINSIC PATHWAY 11399482,16888647 tumor necrosis factor, alpha [Source:RefSeq_peptide;Acc:NP_998024] Tnfa binds selectively to Tnfrsf1a, the zebrafish ortholog of TNFR1A [16888647] .
MCL1A MYELOID CELL LEUKEMIA SEQUENCE 1A, ZFMLP1, WU:FB72F02, FB70A08, ZGC:109835, WU:FB70A08, ZFMCL-1A, FB72F02 Zebrafish BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 16888646,11118352 myeloid cell leukemia sequence 1a [Source:RefSeq_peptide;Acc:NP_571674] Ectopic expression of Mcl1a in zebrafish embryos inhibits apoptosis induced by several pro-apoptotic Bcl2 family members [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ] and gamma-irradiation [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ]. Simultaneous knockdown of both Mcl1a and Mcl1b in zebrafish embryos using antisense morpholino oligonucleotides significantly decreases viability and increases sensitivity to apoptosis induced by the Apo2L/TRAIL ortholog Tnfsf10l3 [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ].
FASLG FAS LIGAND (TNF SUPERFAMILY, MEMBER 6), FASL, ZGC:162027 Zebrafish DEATH LIGAND UNDEFINED EXTRINSIC PATHWAY 16888647 Fas ligand (TNF superfamily, member 6) [Source:RefSeq_peptide;Acc:NP_001036166]
TNFB TUMOR NECROSIS FACTOR B (TNF SUPERFAMILY, MEMBER 2), TNF-ALPHA, TNF , TNF2, TNF-A_V2, TNFA-LIKE Zebrafish DEATH LIGAND UNDEFINED EXTRINSIC PATHWAY 11399482,16888647 tumor necrosis factor (TNF superfamily, member 2) [Source:RefSeq_peptide;Acc:NP_001019618]
CASP3A CASP3; MGC100890; ZGC:100890; CASP3A Zebrafish CASPASE APOPTOSIS ,UNDEFINED 11695990,16888647 caspase 3, apoptosis-related cysteine protease [Source:RefSeq_peptide;Acc:NP_571952] Ectopic expression of Casp3a in zebrafish embryos and fish fathead minnow tailbud cells induces apoptosis 11695990 . Activated Caspase-3 is detected in zebrafish embryos following gamma-irradiation and ectopic expression of numerous pro-apoptotic genes 16888646 . Recombinant Casp3a shows strong activity toward the mammalian Caspase-3 and -7 substrate Ac-DEVD-MCA and weak activity toward Caspase-1, -6, -8, and -9 substrates [11695990] . Structural information for zebrafish Casp3a has been obtained by X-ray crystallography [16842121] .
BAXA BAXA, BCL2-ASSOCIATED X PROTEIN A, WU:FJ16E01, ZBAX1, BAX, FJ16E01, WU:FC50B10 Zebrafish BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 16888646,15630097 bcl2-associated X protein, a [Source:RefSeq_peptide;Acc:NP_571637] Overexpression of Baxa RNA in early stage zebrafish embryos induces Caspase-3 activation and apoptosis [16888646]. Knockdown of Baxa using antisense morpholino oligonucleotides protects zebrafish embryos from apoptosis in response to gamma-irradiation [16888646]. Baxa transcription is induced by tp53 following gamma-irradiation in zebrafish embryos [15630097].
BCL2 BCL-2, B-CELL LEUKEMIA/LYMPHOMA 2, ZBLP2 Zebrafish BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 16888647,16888646,18404156,18510930 Bcl2 (B-cell leukemia/lymphoma 2). [Source:UniProtKB/TrEMBL;Acc:Q564A4] Ectopic expression of Bcl2 in zebrafish embryos inhibits apoptosis induced by multiple stimuli including death receptors [16888647], ectopic expression of several pro-apoptotic Bcl2 family members [16888646], and gamma-irradiation [16888646]. full-length zebrafish bcl2 protein binds strongly to the BH3 domain peptide from zebrafish bim, binds weakly to bida, bad, and bbc3, and does not bind at all to pmaip1 [18404156]. Zebrafish Bcl2 promotes survival following growth factor withdrawal in murine FL5.12 cells and binds directly to human Bim, Bax, and Puma in this context [18510930].
BAXB BAXB, ZBAX2, BCL2-ASSOCIATED X PROTEIN B, ZGC:112983 Zebrafish BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 16888646 hypothetical protein LOC503609 [Source:RefSeq_peptide;Acc:NP_001013314] Overexpression of Baxb in early stage zebrafish embryos induces caspase-3 activation and apoptosis [16888646]. Knockdown of Baxb using antisense morpholino oligonucleotides protects zebrafish embryos from apoptosis in response to gamma-irradiation [16888646].Ectopic expression induces apoptosis [16888646].
TNFSF10L3 TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY MEMBER 10 LIKE 3, DL1B, DR_TRAIL-LIKE V1 Zebrafish DEATH LIGAND APOPTOSIS EXTRINSIC PATHWAY 16888647,17548633 tumor necrosis factor (ligand) superfamily, member 10 like 3 [Source:RefSeq_peptide;Acc:NP_001036178] Ectopic expression of Tnfsf10l3 in zebrafish embryos induces apoptosis in the notochord and erythroid cells [16888647] . Tnfsf10l3 directly associates with the zebrafish death receptor Hdr [16888647] . Tnfsf10l3-induced apoptosis can be blocked by ectopic expression of zebrafish Cflar or by knockdown of endogenous Hdr or FADD [16888647] . Zebrafish Tnfsf10l3 is more structurally related to Apo2L-like (a second copy of Apo2L/TRAIL found in avian species but not mammals) than to mammalian Apo2L/TRAIL due to additional cysteine residues in its extracellular domain 16888647 .
TRADD TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN, ZGC:103556, WU:FC59E02 Zebrafish DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN APOPTOSIS EXTRINSIC PATHWAY 16888647 Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain protein). [Source:UniProtKB/Swiss-Prot;Acc:Q9I9N5] Ectopic expression of TRADD in zebrafish embryos induces apoptosis [16888647] . Knockdown of TRADD using antisense morpholino oligonucleotides does not protect zebrafish embryos from apoptosis induced by ectopic expression of Apo2L/TRAIL orthologs [16888647] .
BMF2 BCL2 MODIFYING FACTOR 2, SI:CH211-119B12.7 Zebrafish BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 16888646 Bmf2 [Source:RefSeq_peptide;Acc:NP_001038938] Ectopic expression of Bmf2 in zebrafish embryos induces apoptosis [16888646].
FAS FAS LIGAND (TNF SUPERFAMILY, MEMBER 6), FAS Zebrafish DEATH RECEPTOR APOPTOSIS EXTRINSIC PATHWAY 16888647 Fas (TNF receptor superfamily, member 6) [Source:RefSeq_peptide;Acc:XP_690447] Ectopic expression of Fas in zebrafish embryos and human cell lines induces apoptosis [16888647].
BIRC2 BACULOVIRAL IAP REPEAT-CONTAINING 2, IAP1, BIRC3 Zebrafish BIR-CONTAINING PROTEIN;IAP APOPTOSIS TNF/NF-KAPPAB SIGNALING 17934460 baculoviral IAP repeat-containing 2 [Source:RefSeq_peptide;Acc:NP_919376] A loss of function mutation in the zebrafish Birc2 locus produces a hemorrhagic phenotype, vascular regression, and Caspase-8-dependent endothelial cell apoptosis [17934460]. Zebrafish Birc2 binds endogenous mammalian TRAF2 when transfected into HEK293 cells [17934460].
BIK BCL2-INTERACTING KILLER (APOPTOSIS-INDUCING), SI:DKEY-31F5.6 Zebrafish BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 16888646 BCL2-interacting killer (apoptosis-inducing) [Source:RefSeq_peptide;Acc:NP_001038503] Ectopic expression of Bik in zebrafish embryos induces apoptosis [16888646].
BOKA BCL2-RELATED OVARIAN KILLER A, BOK, ZBOK1, ZGC:100979 Zebrafish BCL-2 FAMILY;MULTIDOMAIN BCL-2 UNDEFINED INTRINSIC PATHWAY 16888646 Bcl-2-related ovarian killer protein homolog A (zBok1). [Source:UniProtKB/Swiss-Prot;Acc:Q6DC66]
BAD BCL2-ANTAGONIST OF CELL DEATH, WU:FA01B12, PROAPOPTOTIC BH3-ONLY PROTEIN, FA01B12, WU:FA01B12, WU:FA96D04 Zebrafish BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY 16888646,12727206,18404156 BCL2-antagonist of cell death [Source:RefSeq_peptide;Acc:NP_571654] Overexpression of Zebrafish Bad induces apoptosis.
CASP3B CASPASE 3, APOPTOSIS-RELATED CYSTEINE PROTEASE B, CASPASE-3B, CASP3B, CASP3L Zebrafish CASPASE APOPTOSIS UNDEFINED 16888647 caspase 3, apoptosis-related cysteine protease b [Source:RefSeq_peptide;Acc:NP_001041531]
CFLAR CASP8 AND FADD-LIKE APOPTOSIS REGULATOR, CLARP1, FLIP Zebrafish CASPASE APOPTOSIS EXTRINSIC PATHWAY 16888647 CASP8 and FADD-like apoptosis regulator [Source:RefSeq_peptide;Acc:NP_919380] Cflar contains N-terminal death effector domains (DEDs) and an enzymatically inactive caspase cataltic domain [16888647]. Ectopic expression of Cflar in zebrafish embryos prevents induction of apoptosis by the Apo2L/TRAIL orthologs [16888647].
TNFSF10L2 TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY MEMBER 10 LIKE 2, DL2, ZGC:92320, DR_TRAIL-LIKE V3 Zebrafish DEATH LIGAND APOPTOSIS EXTRINSIC PATHWAY 16888647,17548633 tumor necrosis factor (ligand) superfamily, member 10 like 2 [Source:RefSeq_peptide;Acc:NP_001002593] Ectopic expression of Tnfsf10l2 in zebrafish embryos induces apoptosis in the notochord [16888647] . Tnfsf10l2 directly associates with the zebrafish death receptor Tnfrsfa and Tnfsf10l2-induced apoptosis can be blocked by knockdown of endogenous Tnfrsfa [16888647] . Zebrafish Tnfsf10l2 exhibits greater structural similarity to mammalian Apo2L/TRAIL than other zebrafish Apo2L/TRAIL homologs 16888647 .
TNFSF10L4 TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY, MEMBER 10 LIKE 4, ZGC:113297, DL3, DR_TRAIL-LIKE V4 Zebrafish DEATH LIGAND UNDEFINED EXTRINSIC PATHWAY 16888647,17548633 death ligand 3 [Source:RefSeq_peptide;Acc:NP_001013301] Zebrafish tnfsf10l4 shows greater sequence divergence from mammalian Apo2L/TRAIL than other zebrafish Apo2L/TRAIL homologs 16888647 .
CASP8 CASPASE 8, CASPASE-8, ZCASPASE-8A, MGC92075, ZGC:92075 Zebrafish CASPASE APOPTOSIS EXTRINSIC PATHWAY 16888647,17459614 caspase 8, apoptosis-related cysteine peptidase [Source:RefSeq_peptide;Acc:NP_571585] Ectopic expression of Casp8 in zebrafish embryos induces apoptosis [16888647]. Zebrafish Casp8 directly associates with FADD through homophilic death effector domain (DED) interactions [17459614]. Zebrafish Casp8 can mediate apoptosis following death receptor activation in mouse embryonic fibroblast cells that lack endogenous caspase-8 [17459614].
CASP2 CASPASE 2 Zebrafish CASPASE APOPTOSIS UNDEFINED 16888647,18510930 caspase 2, apoptosis-related cysteine protease [Source:RefSeq_peptide;Acc:NP_001036160] Ectopic expression of Casp2 in zebrafish embryos induces apoptosis [16888647]. Checkpoint kinase 1 (Chk1) suppresses a Casp2-dependent apoptotic program in zebrafish that can mediate gamma-radiation-induced apoptosis [18510930].
BMF1 Zebrafish BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 16888646 Bcl2 modifying factor 1 [Source:RefSeq_peptide;Acc:NP_001038689] Ectopic expression of Bmf1 in zebrafish embryos induces apoptosis [16888646].
FADD FAS (TNFRSF6)-ASSOCIATED VIA DEATH DOMAIN Zebrafish DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN;DED ADAPTER PROTEIN APOPTOSIS EXTRINSIC PATHWAY 16888647,17459614 Fas (tnfrsf6)-associated via death domain [Source:RefSeq_peptide;Acc:XP_001923893] Ectopic expression of Casp8 in zebrafish embryos and human cell lines induces apoptosis [16888647]. Knockdown of FADD using antisense morpholino oligonucleotides protects zebrafish embryos from apoptosis induced by ectopic expression of Apo2L/TRAIL orthologs [16888647]. Zebrafish FADD directly associates with Casp8 through homophilic death effector domain (DED) interactions [17459614].
BIDA BID, SI:CH211-238N5.6 Zebrafish BCL-2 FAMILY;BH3-ONLY APOPTOSIS EXTRINSIC PATHWAY,INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 16888646,18404156,16888647 BH3 interacting domain death agonist [Source:RefSeq_peptide;Acc:NP_001073295] Ectopic expression of Bida in zebrafish embryos induces apoptosis [16888646,18404156]. Zebrafish Bida contains a putative caspase-8 cleavage site that may allow for proteolytic activation by the extrinsic apoptosis pathway [16888647]. The BH3 domain peptide from Bida binds weakly to the full-length zebrafish bcl2 protein [18404156].
CASP8L2 CASPASE 8, APOPTOSIS-RELATED CYSTEINE PEPTIDASE LIKE 2,CASP8L2, CASPASE-8B Zebrafish CASPASE APOPTOSIS UNDEFINED 16888647 caspase 8, apoptosis-related cysteine peptidase, like 2 [Source:RefSeq_peptide;Acc:XP_685430] Casp8l2 contains N-terminal death effector domains (DEDs) similar to mammalian Caspase-8 but has a QACRG active site motif that is more reminiscent of mammalian Caspase-2 [16888647].
PMAIP1 PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1, NOXA, ZGC:162379 Zebrafish BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 16888646,18404156 phorbol-12-myristate-13-acetate-induced protein 1 [Source:RefSeq_peptide;Acc:NP_001038939] Ectopic expression of Pmaip1 in zebrafish embryos induces apoptosis [ Ref: 16888646 , Ref: 18404156 "> Ref: Ref: 18404156 ]. The BH3 domain peptide from zebrafish Pmaip1 induces cytochrome c release in mitochondria isolated from mouse embryonic fibroblasts (MEFs) [ Ref: 18404156 "> Ref: Ref: 18404156 ].
BAD BCL2L8, BBC2 Human BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 7834748 Bcl2 antagonist of cell death (BAD)(Bcl-2-binding component 6)(Bcl-XL/Bcl-2-associated death promoter)(Bcl-2-like 8 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q92934] The murine counterpart for Bad participates in regulation of glucose metabolism
CASP10 MCH4 Human CASPASE APOPTOSIS EXTRINSIC PATHWAY 8755496 Caspase-10 Precursor (CASP-10)(EC 3.4.22.63)(ICE-like apoptotic protease 4)(Apoptotic protease Mch-4)(FAS-associated death domain protein interleukin-1B-converting enzyme 2)(FLICE2) [Contains Caspase-10 subunit p23/17;Caspase-10 subunit p12] [Source:UniProtKB/Swiss-Prot;Acc:Q92851]
CFLAR CASH, CASPER, CLARP, FLAME, FLIP, I-FLICE, MRIT Human CASPASE,DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN;OTHER APOPTOSIS EXTRINSIC PATHWAY 9217161 CASP8 and FADD-like apoptosis regulator Precursor (Cellular FLICE-like inhibitory protein)(c-FLIP)(Caspase-eight-related protein)(Casper)(Caspase-like apoptosis regulatory protein)(CLARP)(MACH-related inducer of toxicity)(MRIT)(Caspase homolog)(CASH)(Inhibitor of FLICE)(I-FLICE)(FADD-like antiapoptotic molecule 1)(FLAME-1)(Usurpin) [Contains CASP8 and FADD-like apoptosis regulator subunit p43;CASP8 and FADD-like apoptosis regulator subunit p12] [Source:UniProtKB/Swiss-Prot;Acc:O15519]
AK2 Human OTHER 9434148,9894606 Adenylate kinase isoenzyme 2, mitochondrial (AK 2)(EC 2.7.4.3)(ATP-AMP transphosphorylase 2) [Source:UniProtKB/Swiss-Prot;Acc:P54819] Adenilate kinase-2 is released from mitochondria during apoptosis, but its function remains unknown
BID Human BCL-2 FAMILY;BH3-ONLY APOPTOSIS EXTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 8918887 BH3-interacting domain death agonist (p22 BID)(BID) [Contains BH3-interacting domain death agonist p15(p15 BID);BH3-interacting domain death agonist p13(p13 BID);BH3-interacting domain death agonist p11(p11 BID)] [Source:UniProtKB/Swiss-Prot;Acc:P55957]
BIRC3 CIAP2, HIAP-1, MIHC, RNF49, MALT2 Human BIR-CONTAINING PROTEIN;IAP APOPTOSIS,IMMUNITY TNF/NF-KAPPAB SIGNALING 194641989,16339151 Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1)(HIAP-1)(HIAP1)(C-IAP2)(TNFR2-TRAF-signaling complex protein 1)(IAP homolog C)(Apoptosis inhibitor 2)(API2)(RING finger protein 49) [Source:UniProtKB/Swiss-Prot;Acc:Q13489]
FAS CD95, APO-1 Human DEATH RECEPTOR APOPTOSIS EXTRINSIC PATHWAY 1713127 Tumor necrosis factor receptor superfamily member 6 Precursor (FASLG receptor)(Apoptosis-mediating surface antigen FAS)(Apo-1 antigen)(CD95 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P25445]
TNFRSF1B TNFBR, TNFR80, TNF-R75, TNF-R-II, P75, CD120B Human DEATH RECEPTOR APOPTOSIS EXTRINSIC PATHWAY,TNF/NF-KAPPAB SIGNALING 11239407,7876558 Tumor necrosis factor receptor superfamily member 1B Precursor (Tumor necrosis factor receptor 2)(TNF-R2)(Tumor necrosis factor receptor type II)(p75)(p80 TNF-alpha receptor)(CD120b antigen)(Etanercept) [Contains Tumor necrosis factor receptor superfamily member 1b, membrane form;Tumor necrosis factor-binding protein 2(TBPII)(TBP-2)] [Source:UniProtKB/Swiss-Prot;Acc:P20333]
BAK1 BAK2 Human BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 7715730 Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK)(Bcl-2-like 7 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q16611]
TRAF1 EBI6 Human OTHER IMMUNITY TNF/NF-KAPPAB SIGNALING 8069916 TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) [Source:UniProtKB/Swiss-Prot;Acc:Q13077]
CASP8 MCH5, MACH, FLICE Human CASPASE APOPTOSIS EXTRINSIC PATHWAY 8681376 Caspase-8 Precursor (CASP-8)(EC 3.4.22.61)(ICE-like apoptotic protease 5)(MORT1-associated CED-3 homolog)(MACH)(FADD-homologous ICE/CED-3-like protease)(FADD-like ICE)(FLICE)(Apoptotic cysteine protease)(Apoptotic protease Mch-5)(CAP4) [Contains Caspase-8 subunit p18;Caspase-8 subunit p10] [Source:UniProtKB/Swiss-Prot;Acc:Q14790]
TNFRSF1A TNF-R, TNFAR, TNFR60, TNF-R-I, CD120A, TNF-R55 Human DEATH RECEPTOR APOPTOSIS,NECROPTOSIS EXTRINSIC PATHWAY,TNF/NF-KAPPAB SIGNALING 8397073,11239407 Tumor necrosis factor receptor superfamily member 1A Precursor (p60)(TNF-R1)(TNF-RI)(TNFR-I)(p55)(CD120a antigen) [Contains Tumor necrosis factor receptor superfamily member 1A, membrane form;Tumor necrosis factor-binding protein 1(TBPI)] [Source:UniProtKB/Swiss-Prot;Acc:P19438]
ICAM3 Human APOPTOSIS APOPTOTIC CELL CLEARANCE 18073771 Intercellular adhesion molecule 3 Precursor (ICAM-3)(ICAM-R)(CDw50)(CD50 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P32942]
BIRC1 NLRB1 Human OTHER IMMUNITY INFLAMMASOME 8552191,18854135 Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein) [Source:UniProtKB/Swiss-Prot;Acc:Q13075]
CYLD Human OTHER APOPTOSIS EXTRINSIC PATHWAY 18485876 Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15)(Ubiquitin thioesterase CYLD)(Ubiquitin-specific-processing protease CYLD)(Deubiquitinating enzyme CYLD) [Source:UniProtKB/Swiss-Prot;Acc:Q9NQC7]
BAX BCL2L4 Human BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 8358790 Apoptosis regulator BAX [Source:UniProtKB/Swiss-Prot;Acc:Q07812]
BIRC5 Human BIR-CONTAINING PROTEIN;OTHER CELL DEATH (OTHER) 9256286,11329368,16962308 Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin)(Apoptosis inhibitor 4) [Source:UniProtKB/Swiss-Prot;Acc:O15392] Survivin is a protein with homology to IAPs but whose main role is the regulation of mitosis, not cell death.
NLRP1 KIAA0926, DKFZP586O1822, CARD7, NAC, CLR17.1, DEFCAP Human CARD-CONTAINING PROTEIN;CARD ADAPTER PROTEIN IMMUNITY INFLAMMASOME 12563287,15952891 NACHT, LRR and PYD domains-containing protein 1 (Death effector filament-forming ced-4-like apoptosis protein)(Nucleotide-binding domain and caspase recruitment domain)(Caspase recruitment domain-containing protein 7) [Source:UniProtKB/Swiss-Prot;Acc:Q9C000]
SH3GLB1 CGI-61, KIAA0491, BIF-1 Human OTHER APOPTOSIS INTRINSIC PATHWAY 11259440,19074440 Endophilin-B1 (SH3 domain-containing GRB2-like protein B1)(Bax-interacting factor 1)(Bif-1) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y371]
BCL2L13 MIL1, BCL-RAMBO, RAMBO Human BCL-2 FAMILY;MULTIDOMAIN BCL-2 11262395 Bcl-2-like 13 protein (Protein Mil1)(Bcl-rambo) [Source:UniProtKB/Swiss-Prot;Acc:Q9BXK5]
BIK NBK/BLK Human BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 8816500,11884414 Bcl-2-interacting killer (Apoptosis inducer NBK)(BP4)(BIP1) [Source:UniProtKB/Swiss-Prot;Acc:Q13323]
GZMB GRB, GRANZYME B Human OTHER; 11278459,17283187 Granzyme B Precursor (EC 3.4.21.79)(Granzyme-2)(T-cell serine protease 1-3E)(Cytotoxic T-lymphocyte proteinase 2)(Lymphocyte protease)(SECT)(Cathepsin G-like 1)(CTSGL1)(CTLA-1)(Fragmentin-2)(Human lymphocyte protein)(HLP)(C11) [Source:UniProtKB/Swiss-Prot;Acc:P10144] Human Granzyme B induces apoptosis mainly through Bid cleavage.
XIAP HILP Human BIR-CONTAINING PROTEIN;IAP APOPTOSIS INTRINSIC PATHWAY,EXTRINSIC PATHWAY 9230442 Baculoviral IAP repeat-containing protein 4 (EC 6.3.2.-)(E3 ubiquitin-protein ligase XIAP)(Inhibitor of apoptosis protein 3)(X-linked inhibitor of apoptosis protein)(X-linked IAP)(IAP-like protein)(HILP) [Source:UniProtKB/Swiss-Prot;Acc:P98170]
TRADD HS.89862 Human DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN APOPTOSIS EXTRINSIC PATHWAY 7758105 Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein)(TNFRSF1A-associated via death domain) [Source:UniProtKB/Swiss-Prot;Acc:Q15628]
PYCARD TMS-1, CARD5, ASC Human CARD-CONTAINING PROTEIN;CARD ADAPTER PROTEIN IMMUNITY INFLAMMASOME 10567338,11103776 Apoptosis-associated speck-like protein containing a CARD (hASC)(PYD and CARD domain-containing protein)(Target of methylation-induced silencing 1)(Caspase recruitment domain-containing protein 5) [Source:UniProtKB/Swiss-Prot;Acc:Q9ULZ3]
BMF FLJ00065 Human BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 11546872,19109899 Bcl-2-modifying factor [Source:UniProtKB/Swiss-Prot;Acc:Q96LC9]
TRAIL-R1, DR4 TNFRSF10A, DR4, CD261 Human DEATH RECEPTOR APOPTOSIS EXTRINSIC PATHWAY 9082980 Tumor necrosis factor receptor superfamily member 10A Precursor (Death receptor 4)(TNF-related apoptosis-inducing ligand receptor 1)(TRAIL receptor 1)(TRAIL-R1)(CD261 antigen) [Source:UniProtKB/Swiss-Prot;Acc:O00220]
BNIP3L NIX, BNIP3A Human BCL-2 FAMILY;BH3-ONLY CELL DEATH (OTHER),APOPTOSIS 9575197,19136941 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (NIP3-like protein X)(NIP3L)(BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A)(Adenovirus E1B19K-binding protein B5) [Source:UniProtKB/Swiss-Prot;Acc:O60238]
CASPASE-14 CASP14, CASPASE 14, MICE, MGC119078, MGC119079 Human CASPASE CELL DEATH (OTHER) UNDEFINED 10203698,11175259 Caspase-14 Precursor (CASP-14)(EC 3.4.22.-) [Source:UniProtKB/Swiss-Prot;Acc:P31944] Caspase-14 is associated with death of skin cells in a non-apoptotic manner
PUMA JFY1, PUMA, BBC3 Human BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 11463391,11463392,11572983 Bcl-2-binding component 3 (p53 up-regulated modulator of apoptosis)(JFY-1)
CASP2 ICH1 Human CASPASE 8087842,19581929,9573047 Caspase-2 Precursor (CASP-2)(EC 3.4.22.55)(ICH-1 protease)(Neural precursor cell expressed developmentally down-regulated protein 2)(NEDD-2) [Contains Caspase-2 subunit p18;Caspase-2 subunit p13;Caspase-2 subunit p12] [Source:UniProtKB/Swiss-Prot;Acc:P42575]
MAPK8 JNK, JNK1, SAPK1 Human OTHER CELL DEATH (OTHER) TNF/NF-KAPPAB SIGNALING 8137421 Mitogen-activated protein kinase 8 (EC 2.7.11.24)(Stress-activated protein kinase JNK1)(c-Jun N-terminal kinase 1)(JNK-46) [Source:UniProtKB/Swiss-Prot;Acc:P45983]
CIAP1 BIRC2, CIAP1, HIAP-2, MIHB, RNF48 Human BIR-CONTAINING PROTEIN;IAP APOPTOSIS,IMMUNITY,NECROPTOSIS TNF/NF-KAPPAB SIGNALING 194641989,16339151,18022363,18022362,19012953 Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2)(HIAP-2)(C-IAP1)(TNFR2-TRAF-signaling complex protein 2)(IAP homolog B)(RING finger protein 48)
GAPDH GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE Human OTHER CELL DEATH (OTHER) UNDEFINED 17540177 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) GAPDH contributes to recovery from caspase-independent cell death (CICD) after mitochondrial permeabilization [17540177]
HTRA2 OMI, PARK13 Human OTHER CELL DEATH (OTHER) POSTMITOCHONDRIAL CASPASE ACTIVATION 11583623 Serine protease HTRA2, mitochondrial Precursor (EC 3.4.21.108)(High temperature requirement protein A2)(HtrA2)(Omi stress-regulated endoprotease)(Serine proteinase OMI)(Serine protease 25) [Source:UniProtKB/Swiss-Prot;Acc:O43464]
FASL FASL, CD178, FAS LIGAND Human DEATH LIGAND APOPTOSIS EXTRINSIC PATHWAY 7505205 Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand)(Fas ligand)(CD95L protein)(Apoptosis antigen ligand)(APTL)(CD178 antigen) [Contains Tumor necrosis factor ligand superfamily member 6, membrane form;Tumor necrosis factor ligand superfamily member 6, soluble form]
APAF1 CED4 Human CARD-CONTAINING PROTEIN;CARD ADAPTER PROTEIN APOPTOSIS INTRINSIC PATHWAY,POST-MITOCHONDRIAL CASPASE ACTIVATION 9267021,15103327 Apoptotic protease-activating factor 1 (Apaf-1) [Source:UniProtKB/Swiss-Prot;Acc:O14727]
TRAIL-R2, TNFRSF10B TNFRSF10B, TRAIL-R2, DR5, KILLER, TRICK2A, TRICK2B, APO-2, CD262 Human DEATH RECEPTOR APOPTOSIS EXTRINSIC PATHWAY 9311998,9325248,9242611 Tumor necrosis factor receptor superfamily member 10B Precursor (Death receptor 5)(TNF-related apoptosis-inducing ligand receptor 2)(TRAIL receptor 2)(TRAIL-R2)(CD262 antigen) [Source:UniProtKB/Swiss-Prot;Acc:O14763]
BCL2L14 BCLG, BCL-G Human BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS 11054413 Apoptosis facilitator Bcl-2-like 14 protein (Apoptosis regulator Bcl-G) [Source:UniProtKB/Swiss-Prot;Acc:Q9BZR8]
TNFSF10 TRAIL, APO-2L, APO2L TL2, CD253 Human DEATH LIGAND APOPTOSIS EXTRINSIC PATHWAY 8663110 Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand)(Protein TRAIL)(Apoptosis ligand 2, Apo-2 ligand)(Apo-2L)(Apo2L)(CD253 antigen)
LRP1 CD91 Human OTHER; APOPTOSIS APOPTOTIC CELL CLEARANCE 16239148,18073771 Prolow-density lipoprotein receptor-related protein 1 Precursor (LRP)(Alpha-2-macroglobulin receptor)(A2MR)(Apolipoprotein E receptor)(APOER)(CD91 antigen) [Contains Low-density lipoprotein receptor-related protein 1 85 kDa subunit(LRP-85);Low-density lipoprotein receptor-related protein 1 515 kDa subunit(LRP-515);Low-density lipoprotein receptor-related protein 1 intracellular domain(LRPICD)] [Source:UniProtKB/Swiss-Prot;Acc:Q07954]
CSE1L CAS, XPO2, CSE1 Human OTHER APOPTOSIS EXTRINSIC PATHWAY,POST-MITOCHONDRIAL CASPASE ACTIVATION 18439902 Exportin-2 (Exp2)(Importin-alpha re-exporter)(Chromosome segregation 1-like protein)(Cellular apoptosis susceptibility protein) [Source:UniProtKB/Swiss-Prot;Acc:P55060]
BCL2L12 BCL-2L12 Human BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS UNDEFINED 11401436,19617565,17210792,18669646 Bcl-2-related proline-rich protein (Bcl-2-like 12 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9HB09] It is still debated if Bcl-2L12 has a pro- or antiapoptotic function. Data from Nakajima et al. point towards a slightly pro-apoptotic function that is cell-type specific and so far only shown with UV irradation. On the other hand, the inhibiting function of Bcl-2L12 on caspase-3/-7 downstream of mitochondria cannot be reproduced.
TRAF2 TRAP3 Human OTHER IMMUNITY TNF/NF-KAPPAB SIGNALING 8069916,8702708 TNF receptor-associated factor 2 (Tumor necrosis factor type 2 receptor-associated protein 3) [Source:UniProtKB/Swiss-Prot;Acc:Q12933]
RIPK3 Human OTHER NECROPTOSIS TNF/NF-KAPPAB SIGNALING 19524512,19524513 Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1)(RIP-like protein kinase 3)(Receptor-interacting protein 3)(RIP-3) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y572]
BCL2L2 KIAA0271, BCL-W Human BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 8761287 Apoptosis regulator Bcl-W (Bcl-2-like 2 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q92843]
XAF1 Human OTHER APOPTOSIS 11175744 XIAP-associated factor 1 (BIRC4-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:Q6GPH4]
CASP9 CASPASE-9, CASPASE 9, CASP9, MCH6, ICE-LAP6, APAF-3 Human CASPASE APOPTOSIS INTRINSIC PATHWAY 8900201 Caspase-9 Precursor (CASP-9)(EC 3.4.22.62)(ICE-like apoptotic protease 6)(ICE-LAP6)(Apoptotic protease Mch-6)(Apoptotic protease-activating factor 3)(APAF-3) [Contains Caspase-9 subunit p35;Caspase-9 subunit p10] [Source:UniProtKB/Swiss-Prot;Acc:P55211] Caspase-9 is the binding partner of Apaf-1, becoming activated upon binding to the latter in response to mitochondrial cytochrome c efflux. Apaf-1 and caspase-9 form a holoenzyme (called the apoptosome) which is comprised of seven molecules of Apaf-1 and possibly a similar number of caspase-9 molecules (although the precise number of caspase-9 molecules within the apoptosome may be as low as 1 or 2). Upon activation within the apoptosome, caspase-9 then directly processes and activates caspases -3 and -7 downstream. Other than caspases -3 and -7, few other substrates for caspase-9 are known.
ANXA1 ANX1, LPC1, ANNEXIN-1, LIPOCORTIN I Human OTHER APOPTOSIS APOPTOTIC CELL CLEARANCE 17372018,18073771 Annexin A1 (Annexin-1)(Annexin I)(Lipocortin I)(Calpactin II)(Chromobindin-9)(p35)(Phospholipase A2 inhibitory protein) [Source:UniProtKB/Swiss-Prot;Acc:P04083]
HRK DP5 Human BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY 9130713,9228060 Activator of apoptosis harakiri (Neuronal death protein DP5)(BH3-interacting domain-containing protein 3) [Source:UniProtKB/Swiss-Prot;Acc:O00198]
RIPK1 RIP Human DEATH DOMAIN-CONTAINING PROTEIN;OTHER NECROPTOSIS,APOPTOSIS TNF/NF-KAPPAB SIGNALING 18408713,18485876 Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1)(Serine/threonine-protein kinase RIP)(Cell death protein RIP)(Receptor-interacting protein) [Source:UniProtKB/Swiss-Prot;Acc:Q13546]
CASP1 ICE, CASPASE-1, CASPASE 1, CASP1 Human CASPASE IMMUNITY INFLAMMASOME 1373520,11967258 Caspase-1 Precursor (CASP-1)(EC 3.4.22.36)(Interleukin-1 beta convertase)(IL-1BC)(Interleukin-1 beta-converting enzyme)(IL-1 beta-converting enzyme)(ICE)(p45) [Contains Caspase-1 subunit p20;Caspase-1 subunit p10] [Source:UniProtKB/Swiss-Prot;Acc:P29466] Caspase-1 is instrumental in processing the precursor forms of interleukin-1beta and interleukin-18 to their biologically active forms. Although quite a few other substrates for caspase-1 have been claimed, these have invariably been found using non-physiological concentrations of caspase-1 (i.e. at concentrations in excess of 200 nanoMolar, sometimes ridiculously so) and are therefore unlikely to be genuine substrates. So, to date, there are two natural substrates for caspase-1 known (IL-1beta and IL-18).
CASP5 ICE(REL)III Human CASPASE IMMUNITY INFLAMMASOME 15163405,8617266 Caspase-5 Precursor (CASP-5)(EC 3.4.22.58)(ICH-3 protease)(TY protease)(ICE(rel)-III) [Contains Caspase-5 subunit p20;Caspase-5 subunit p10] [Source:UniProtKB/Swiss-Prot;Acc:P51878]
BCL2L10 DIVA, BOO, BCL-B Human BCL-2 FAMILY,BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY 9878060,9829980 Apoptosis regulator Bcl-B (Bcl-2-like 10 protein)(Bcl2-L-10)(Anti-apoptotic protein NrH) [Source:UniProtKB/Swiss-Prot;Acc:Q9HD36]
CASP6 MCH2 Human CASPASE APOPTOSIS 7796396 Caspase-6 Precursor (CASP-6)(EC 3.4.22.59)(Apoptotic protease Mch-2) [Contains Caspase-6 subunit p18;Caspase-6 subunit p11] [Source:UniProtKB/Swiss-Prot;Acc:P55212]
PHAP PHAP, ANP32A, LANP, PP32, I1PP2A, PHAPI, MAPM, MAPMODULIN Human OTHER APOPTOSIS POST-MITOCHONDRIAL CASPASE ACTIVATION 12522243 Acidic leucine-rich nuclear phosphoprotein 32 family member A (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A)(Acidic nuclear phosphoprotein pp32)(Leucine-rich acidic nuclear protein)(Lanp)(Putative HLA-DR-associated protein I)(PHAPI)(Mapmodulin) [Source:UniProtKB/Swiss-Prot;Acc:P39687]
BCL2A1 GRS, BFL1, BCL2L5, ACC-1, ACC-2, A1 Human BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 11929871 Bcl-2-related protein A1 (Protein BFL-1)(Hemopoietic-specific early response protein)(Protein GRS) [Source:UniProtKB/Swiss-Prot;Acc:Q16548]
ARC NOL3, ARC Human CARD-CONTAINING PROTEIN;OTHER UNDEFINED UNDEFINED 9560245 Nucleolar protein 3 (Apoptosis repressor with CARD)(Muscle-enriched cytoplasmic protein)(Myp)(Nucleolar protein of 30 kDa)(Nop30) [Source:UniProtKB/Swiss-Prot;Acc:O60936] The exact role of this protein during apoptosis is still undetermined
TP53 P53, LFS1 Human OTHER APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 19410540,1584781 Cellular tumor antigen p53 (Tumor suppressor p53)(Phosphoprotein p53)(Antigen NY-CO-13) [Source:UniProtKB/Swiss-Prot;Acc:P04637]
NOXA PMAIP1, APR, NOXA Human BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 10807576 Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1)(Immediate-early-response protein APR)(NOXA)
MCL1 BCL2L3 Human BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 7682708,10837489 Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-related protein EAT/mcl1)(mcl1/EAT) [Source:UniProtKB/Swiss-Prot;Acc:Q07820]
BCL2L11 BOD, BIML, BIMEL, BIM Human BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 9430630,19641506 Bcl-2-like protein 11 (Bcl2-interacting mediator of cell death) [Source:UniProtKB/Swiss-Prot;Acc:O43521]
AIF AIF, AIFM1 Human OTHER CELL DEATH (OTHER) UNDEFINED 9989411,15526035 Apoptosis-inducing factor 1, mitochondrial Precursor (EC 1.-.-.-)(Programmed cell death protein 8) The role of this protein during cell death requires further clarification
NLRP3 AGTAVPRL, AII, AVP, FCAS, FCU, NALP3, PYPAF1, MWS, CLR1.1 Human OTHER IMMUNITY INFLAMMASOME 12563287,15952891 NACHT, LRR and PYD domains-containing protein 3 (Cold autoinflammatory syndrome 1 protein)(Cryopyrin)(PYRIN-containing APAF1-like protein 1)(Angiotensin/vasopressin receptor AII/AVP-like) [Source:UniProtKB/Swiss-Prot;Acc:Q96P20]
CASP3 CPP32, CPP32B, YAMA, APOPAIN Human CASPASE APOPTOSIS INTRINSIC PATHWAY,EXTRINSIC PATHWAY 7983002 Caspase-3 Precursor (CASP-3)(EC 3.4.22.56)(Apopain)(Cysteine protease CPP32)(CPP-32)(Yama protein)(SREBP cleavage activity 1)(SCA-1) [Contains Caspase-3 subunit p17;Caspase-3 subunit p12] [Source:UniProtKB/Swiss-Prot;Acc:P42574]
CASP7 MCH3, CMH-1, ICE-LAP3 Human CASPASE APOPTOSIS INTRINSIC PATHWAY,EXTRINSIC PATHWAY 8521391,9070923 Caspase-7 Precursor (CASP-7)(EC 3.4.22.60)(ICE-like apoptotic protease 3)(ICE-LAP3)(Apoptotic protease Mch-3)(CMH-1) [Contains Caspase-7 subunit p20;Caspase-7 subunit p11] [Source:UniProtKB/Swiss-Prot;Acc:P55210]
MOAP1 MAP-1, PNMA4 Human OTHER APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 16199525 Modulator of apoptosis 1 (MAP-1)(MAP1)(Paraneoplastic antigen Ma4) [Source:UniProtKB/Swiss-Prot;Acc:Q96BY2]
ENDOG Human OTHER CELL DEATH (OTHER) 16754658,11452314 Endonuclease G, mitochondrial Precursor (Endo G)(EC 3.1.30.-) [Source:UniProtKB/Swiss-Prot;Acc:Q14249]
FADD MORT1, GIG3 Human DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN,DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN;DED ADAPTER PROTEIN APOPTOSIS EXTRINSIC PATHWAY 7538907 Protein FADD (FAS-associated death domain protein)(FAS-associating death domain-containing protein)(Mediator of receptor induced toxicity) [Source:UniProtKB/Swiss-Prot;Acc:Q13158]
CRADD RAIDD Human DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN APOPTOSIS 8985253,15073321,15947787 Death domain-containing protein CRADD (Caspase and RIP adapter with death domain)(RIP-associated protein with a death domain) [Source:UniProtKB/Swiss-Prot;Acc:P78560]
AVEN PDCD12 Human OTHER APOPTOSIS INTRINSIC PATHWAY 10949025 Cell death regulator Aven [Source:UniProtKB/Swiss-Prot;Acc:Q9NQS1]
BCL2L1 BCLX, BCL2L, BCL-X, BCL-XL, BCL-XS Human BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 8358789 Apoptosis regulator Bcl-X (Bcl-2-like 1 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q07817]
BCL2 BCL-2 Human BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 2848196 Apoptosis regulator Bcl-2 [Source:UniProtKB/Swiss-Prot;Acc:P10415]
CYTOCHROME C HCS, CYCS Human OTHER APOPTOSIS INTRINSIC PATHWAY,POST-MITOCHONDRIAL CASPASE ACTIVATION 8689682,15907471 Cytochrome c [Source:UniProtKB/Swiss-Prot;Acc:P99999] Cytochrome c is a nuclear encoded gene that upon import into the mitochondria obtains a heme moiety forming the holoenzyme. In healthy cells, cytochrome c resides in the mitochondrial intermembrane space where it is required for oxidative phosphorylation by transferring electrons between complexes III and IV of the respiratory chain. During apoptosis, cytochrome c is released from mitochondria following mitochondrial outer membrane permeabilisation where it drives caspase activation [8689682] . Once in the cytosol, cytochrome c binds Apaf-1 leading to formation of the heptameric Apaf-1 caspase activating platform termed the apoptosome. Cytochrome c is absolutely required for caspase activation in the majority of intrinsic apoptosis pathways 1590747
MALT1 Human OTHER IMMUNITY 14576442 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-)(MALT lymphoma-associated translocation)(Paracaspase) [Source:UniProtKB/Swiss-Prot;Acc:Q9UDY8]
TRAIL-R4, TNFRSF10D TNFRSF10D, TRAIL-R4, DCR2, TRUNDD, CD264 Human DEATH RECEPTOR APOPTOSIS EXTRINSIC PATHWAY 9382840 (TNF-related apoptosis-inducing ligand receptor 4)(TRAIL receptor 4)(TRAIL-R4) Tumor necrosis factor receptor superfamily member 10D Precursor (Decoy receptor 2)(DcR2) (TRAIL receptor with a truncated death domain)(CD264 antigen) [Source:UniProtKB/Swiss-Prot;Acc:Q9UBN6]
TRAIL-R3 / TNFSF10C TNFRSF10C, TRAIL-R3, DCR1, LIT, TRID, CD263 Human OTHER APOPTOSIS EXTRINSIC PATHWAY 9314565 Tumor necrosis factor receptor superfamily member 10C Precursor (Decoy receptor 1)(DcR1)(Decoy TRAIL receptor without death domain)(TNF-related apoptosis-inducing ligand receptor 3)(TRAIL receptor 3)(TRAIL-R3)(Trail receptor without an intracellular domain)(Lymphocyte inhibitor of TRAIL)(Antagonist decoy receptor for TRAIL/Apo-2L)(CD263 antigen) [Source:UniProtKB/Swiss-Prot;Acc:O14798]
BNIP3 NIP3 Human BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY 9867803 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Source:UniProtKB/Swiss-Prot;Acc:Q12983]
BOK BCL2L9, BOKL, MGC4631 Human BCL-2 FAMILY;MULTIDOMAIN BCL-2 CELL DEATH (OTHER) 16302269,9535847 Bcl-2-related ovarian killer protein (Hbok) [Source:UniProtKB/Swiss-Prot;Acc:Q9UMX3]
LRDD PIDD, MGC16925, DKFZP434D229 Human DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN 10973264,15073321 Leucine-rich repeat and death domain-containing protein (p53-induced protein with a death domain) [Source:UniProtKB/Swiss-Prot;Acc:Q9HB75]
CALR Human OTHER; APOPTOSIS APOPTOTIC CELL CLEARANCE 16239148,18073771 Calreticulin Precursor (CRP55)(Calregulin)(HACBP)(ERp60)(grp60) [Source:UniProtKB/Swiss-Prot;Acc:P27797]
DIABLO SMAC, DIABLO-S, FLJ25049, FLJ10537 Human IAP ANTAGONIST APOPTOSIS INTRINSIC PATHWAY 10929711 Diablo homolog, mitochondrial Precursor (Second mitochondria-derived activator of caspase)(Smac protein)(Direct IAP-binding protein with low pI) [Source:UniProtKB/Swiss-Prot;Acc:Q9NR28]
CASP4 ICE(REL)II, ICH-2, TX Human CASPASE IMMUNITY 7743998,15123740 Caspase-4 Precursor (CASP-4)(EC 3.4.22.57)(ICH-2 protease)(TX protease)(ICE(rel)-II) [Contains Caspase-4 subunit 1;Caspase-4 subunit 2] [Source:UniProtKB/Swiss-Prot;Acc:P49662]
OPA1 Human OTHER APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 18691924,16115883 Dynamin-like 120 kDa protein, mitochondrial Precursor (Optic atrophy protein 1) [Contains Dynamin-like 120 kDa protein, form S1] [Source:UniProtKB/Swiss-Prot;Acc:O60313]
CASP12 Human CASPASE IMMUNITY INFLAMMASOME 10638761 Inactive caspase-12 (CASP-12) [Source:UniProtKB/Swiss-Prot;Acc:Q6UXS9]
TNF TNFSF2, DIF, TNF-ALPHA Human DEATH LIGAND APOPTOSIS,IMMUNITY EXTRINSIC PATHWAY,TNF/NF-KAPPAB SIGNALING 6392892 Tumor necrosis factor Precursor (TNF-alpha)(Tumor necrosis factor ligand superfamily member 2)(TNF-a)(Cachectin) [Contains Tumor necrosis factor, membrane form;Tumor necrosis factor, soluble form] [Source:UniProtKB/Swiss-Prot;Acc:P01375]
FASL FASL, FAS LIGAND (TNF SUPERFAMILY, MEMBER 6) Mouse DEATH LIGAND APOPTOSIS EXTRINSIC PATHWAY 7511063 Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand)(Fas ligand)(CD95L protein)(CD178 antigen) [Contains Tumor necrosis factor ligand superfamily member 6, membrane form;Tumor necrosis factor ligand superfamily member 6, soluble form] [Source:UniProtKB/Swiss-Prot;Acc:P41047]
BBC3 BBC3, BCL2 BINDING COMPONENT 3, PUMA Mouse BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 14500851 Bcl-2-binding component 3 (p53 up-regulated modulator of apoptosis) [Source:UniProtKB/Swiss-Prot;Acc:Q99ML1]
CD36 Mouse OTHER APOPTOSIS APOPTOTIC CELL CLEARANCE 17101731,18073771 Platelet glycoprotein 4 (Platelet glycoprotein IV)(GPIV)(GPIIIB)(PAS IV)(PAS-4)(CD36 antigen) [Source:UniProtKB/Swiss-Prot;Acc:Q08857] Scavenger receptor which regocnizes oxidized PS on apoptotic cells.
CALR CALREGULIN,CRP55,HACBP,ERP60 Mouse OTHER APOPTOSIS APOPTOTIC CELL CLEARANCE 16239148,10085286 Calreticulin Precursor (CRP55)(Calregulin)(HACBP)(ERp60) [Source:UniProtKB/Swiss-Prot;Acc:P14211]
BAX BAX, BCL2-ASSOCIATED X PROTEIN Mouse CARD-CONTAINING PROTEIN;OTHER APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 9560245 BCL2-associated X protein Gene [Source:MGI Symbol;Acc:MGI:99702]
BID BID, BH3 INTERACTING DOMAIN DEATH AGONIST Mouse BCL-2 FAMILY;BH3-ONLY APOPTOSIS EXTRINSIC PATHWAY 10476969 BH3 interacting domain death agonist Gene [Source:MGI (curated);Acc:Bid-001]
CASPASE-14 CASPASE 14, CASPASE-14, CASP14, MICE, MINI-ICE Mouse CASPASE CELL DEATH (OTHER) UNDEFINED 10203698,17515931 murine caspase 14 Mice deficient in caspase-14 develop skin problems. This protein is involved in keratinocyte differentiation and cornification, which is a non-apoptotic form of cell death.
BCL2L1 BCL2L1, BCL2-LIKE 1, BCL(X)L, BCL-X, BCL-XL, BCL-XS, BCLX Mouse BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 7963517 BCL2-like 1 Gene [Source:MGI (curated);Acc:Bcl2l1-001]
TNFRSF22 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 22, 2810028K06RIK, C130035G06RIK, MDCTRAILR2, SOBA, TNFRH2 Mouse DEATH RECEPTOR UNDEFINED UNDEFINED 18079962,12466268,19476510 Tumor necrosis factor receptor superfamily member 22 (Tumor necrosis factor receptor p60 homolog 2)(TNF receptor family member SOBa)(Decoy TRAIL receptor 2)(TNF receptor homolog 2) [Source:UniProtKB/Swiss-Prot;Acc:Q9ER62]
GZMB GZMB, GRANZYME B,CTLA-1, CTLA1,GRB Mouse OTHER; 8702964,12629051 Granzyme B(G,H) Precursor (EC 3.4.21.79)(Cytotoxic cell protease 1)(CCP1)(CTLA-1)(Fragmentin-2) [Source:UniProtKB/Swiss-Prot;Acc:P04187] Granzyme B cleaves and activates caspases and Bid to induce apoptosis.
BIK BIK, BCL2-INTERACTING KILLER Mouse BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY 9525867,14749373 BCL2-interacting killer [Source:RefSeq peptide;Acc:NP_031572]
BIRC5 API4, IAP4, SURVIVIN, TIAP, APOPTOSIS INHIBITOR 4 Mouse BIR-CONTAINING PROTEIN;OTHER CELL DEATH (OTHER) 12145814,11329368 Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin)(Apoptosis inhibitor 4)(TIAP) [Source:UniProtKB/Swiss-Prot;Acc:O70201] Survivin is a protein with homology to IAPs but whose main role is the regulation of mitosis, not cell death.
APAF1 APAF1, APOPTOTIC PEPTIDASE ACTIVATING FACTOR 1 Mouse CARD-CONTAINING PROTEIN;CARD ADAPTER PROTEIN APOPTOSIS INTRINSIC PATHWAY 9753321 apoptotic peptidase activating factor 1 Gene [Source:MGI Symbol;Acc:MGI:1306796]
RIPK1 Mouse DEATH DOMAIN-CONTAINING PROTEIN;OTHER NECROPTOSIS TNF/NF-KAPPAB SIGNALING 19632174,12654725 receptor (TNFRSF)-interacting serine-threonine kinase 1 Gene [Source:MGI Symbol;Acc:MGI:108212]
BNIP3L BNIP3L, BCL2/ADENOVIRUS E1B INTERACTING PROTEIN 3-LIKE Mouse BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY 9396766 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (NIP3-like protein X)(NIP3L) [Source:UniProtKB/Swiss-Prot;Acc:Q9Z2F7]
TNFRSF10B TNFRSF10B, TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B, DR5, KILLER, KILLER/DR5, LY98, TRAIL RECEPTOR, TRAIL-R2, TRAILR2, TRICK2A, TRICK2B, TRICKB Mouse DEATH RECEPTOR APOPTOSIS EXTRINSIC PATHWAY 18079962,10383128,15713653 Tumor necrosis factor receptor superfamily member 10B Precursor (Death receptor 5)(MK)(CD262 antigen) [Source:UniProtKB/Swiss-Prot;Acc:Q9QZM4] homolog of human TRAIL-R2
BCL2L2 BCL-W, BCLW, GTRGAL2, GTROSA41,BCL2L2, BCL2-LIKE 2 Mouse BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 9500547,9770502 BCL2-like 2 Gene [Source:MGI Symbol;Acc:MGI:108052]
RIPK3 RIPK3, RECEPTOR-INTERACTING SERINE-THREONINE KINASE 3 Mouse OTHER NECROPTOSIS TNF/NF-KAPPAB SIGNALING 19524512,19524513 Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1)(RIP-like protein kinase 3)(Receptor-interacting protein 3)(RIP-3)(mRIP3) [Source:UniProtKB/Swiss-Prot;Acc:Q9QZL0]
TNF TNF, TUMOR NECROSIS FACTOR, DIF, TNF ALPHA, TNF-ALPHA, TNFA, TNFALPHA, TNFSF1A, TUMOR NECROSIS FACTOR-ALPHA Mouse DEATH LIGAND APOPTOSIS EXTRINSIC PATHWAY 2993897 Tumor necrosis factor Precursor (TNF-alpha)(Tumor necrosis factor ligand superfamily member 2)(TNF-a)(Cachectin) [Contains Tumor necrosis factor, membrane form;Tumor necrosis factor, soluble form] [Source:UniProtKB/Swiss-Prot;Acc:P06804]
PMAIP1 NOXA, PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1 Mouse BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 10807576 Phorbol-12-myristate-13-acetate-induced protein 1 (Noxa) [Source:UniProtKB/Swiss-Prot;Acc:Q9JM54]
ANXA1 ANX1, LPC-1, LPC1, ANNEXIN A1, LIPOCORTIN I Mouse OTHER; APOPTOSIS APOPTOTIC CELL CLEARANCE 12516535,18073771 Annexin A1 (Annexin-1)(Annexin I)(Lipocortin I)(Calpactin II)(Chromobindin-9)(p35)(Phospholipase A2 inhibitory protein) [Source:UniProtKB/Swiss-Prot;Acc:P10107]
FAS FAS, FAS (TNF RECEPTOR SUPERFAMILY MEMBER 6) Mouse DEATH RECEPTOR APOPTOSIS EXTRINSIC PATHWAY 1372394 Tumor necrosis factor receptor superfamily member 6 Precursor (FASLG receptor)(Apoptosis-mediating surface antigen FAS)(Apo-1 antigen)(CD95 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P25446]
BAD BBC6, BCL2-ASSOCIATED AGONIST OF CELL DEATH Mouse BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY 9372935 BCL2-associated agonist of cell death Gene [Source:MGI (curated);Acc:Bad-001]
CASP7 CASPASE 7, CASPASE-7, CMH-1, ICE-IAP3, MCH3 Mouse CASPASE APOPTOSIS EXTRINSIC PATHWAY,INTRINSIC PATHWAY,POST-MITOCHONDRIAL CASPASE ACTIVATION 9070923 caspase 7 Gene [Source:MGI Symbol;Acc:MGI:109383]
LRDD PIDD, LRDD, LEUCINE-RICH AND DEATH DOMAIN CONTAINING, 1200011D09RIK Mouse DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN 10973264,19364921 Leucine-rich repeat and death domain-containing protein [Source:UniProtKB/Swiss-Prot;Acc:Q9ERV7]
XIAP X-LINKED INHIBITOR OF APOPTOSIS, 1110015C02RIK, AIPA, API3, BIRC4, IAP3, ILP-1 Mouse BIR-CONTAINING PROTEIN;IAP APOPTOSIS INTRINSIC PATHWAY,EXTRINSIC PATHWAY 11313486,9990849,19626005 Baculoviral IAP repeat-containing protein 4 (EC 6.3.2.-)(E3 ubiquitin-protein ligase XIAP)(Inhibitor of apoptosis protein 3)(X-linked inhibitor of apoptosis protein)(X-linked IAP)(IAP homolog A)(MIAP-3)(MIAP3) [Source:UniProtKB/Swiss-Prot;Acc:Q60989]
CASP12 CASP12, CASPASE 12 Mouse CASPASE IMMUNITY INFLAMMASOME 16625199 caspase 12 Gene [Source:MGI Symbol;Acc:MGI:1312922]
CASP1 CASPASE 1, CASPASE-1, ICE, IL1BC, INTERLEUKIN 1 BETA-CONVERTING ENZYME Mouse CASPASE IMMUNITY INFLAMMASOME 9015751 caspase 1 Gene [Source:MGI Symbol;Acc:MGI:96544]
CASP8 CASPASE 8, CASPASE-8, FLICE, MACH, MCH5 Mouse CASPASE APOPTOSIS EXTRINSIC PATHWAY 9729047 caspase 8 Gene [Source:MGI Symbol;Acc:MGI:1261423]
CFLAR CASP8 AND FADD-LIKE APOPTOSIS REGULATOR, 2310024N18RIK, A430105C05RIK, C-FLIP, CASH, CASPER, FLIP Mouse CASPASE,DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN;OTHER APOPTOSIS EXTRINSIC PATHWAY 10894163 CASP8 and FADD-like apoptosis regulator Precursor (Cellular FLICE-like inhibitory protein)(c-FLIP)(Caspase-eight-related protein)(Casper)(Caspase-like apoptosis regulatory protein)(CLARP)(MACH-related inducer of toxicity)(MRIT)(Caspase homolog)(CASH)(Inhibitor of FLICE)(I-FLICE)(FADD-like antiapoptotic molecule 1)(FLAME-1)(Usurpin) [Contains CASP8 and FADD-like apoptosis regulator subunit p43;CASP8 and FADD-like apoptosis regulator subunit p12] [Source:UniProtKB/Swiss-Prot;Acc:O35732]
BOK BOK, BCL2-RELATED OVARIAN KILLER PROTEIN Mouse BCL-2 FAMILY;MULTIDOMAIN BCL-2 9535847 BCL2-related ovarian killer protein Gene [Source:MGI Symbol;Acc:MGI:1858494]
PARP1 PARP1, POLY (ADP-RIBOSE) POLYMERASE FAMILY, MEMBER 1 Mouse OTHER CELL DEATH (OTHER) 15145826 Poly [ADP-ribose] polymerase 1 (PARP-1)(EC 2.4.2.30)(ADPRT)(NAD(+) ADP-ribosyltransferase 1)(Poly[ADP-ribose] synthetase 1)(msPARP) [Source:UniProtKB/Swiss-Prot;Acc:P11103]
BCL2L11 BCL2L11, BCL2-LIKE 11 (APOPTOSIS FACILITATOR), 1500006F24RIK, BIM, BOD Mouse BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 9430630,19641506 BCL2-like 11 (apoptosis facilitator) Gene [Source:MGI (curated);Acc:Bcl2l11-001]
CASP6 CASPASE 6, MCASP-6, MCH2 Mouse CASPASE 19225519,18981099 caspase 6 Gene [Source:MGI (curated);Acc:Casp6-001]
TNFRSF1B TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B, CD120B, P75, P75 TNFR, TNF-ALPHAR2, TNF-R-II, TNF-R2, TNF-R75, TNFALPHA-R2, TNFBR, TNFR-1, TNFR2, TNFR80, TNFRII Mouse DEATH RECEPTOR APOPTOSIS,NECROPTOSIS EXTRINSIC PATHWAY,TNF/NF-KAPPAB SIGNALING 1645445,14532286 Tumor necrosis factor receptor superfamily member 1B Precursor (Tumor necrosis factor receptor 2)(TNF-R2)(Tumor necrosis factor receptor type II)(p75)(p80 TNF-alpha receptor)(CD120b antigen) [Source:UniProtKB/Swiss-Prot;Acc:P25119]
CASP9 CASPASE 9, CASPASE-9, ICE-LAP6, MCH6 Mouse CASPASE APOPTOSIS INTRINSIC PATHWAY,POST-MITOCHONDRIAL CASPASE ACTIVATION 9708735,9708736 caspase 9 [Source:RefSeq peptide;Acc:NP_056548]
DIABLO DIABLO HOMOLOG (DROSOPHILA), 0610041G12RIK, 1700006L01RIK, SMAC Mouse IAP ANTAGONIST 11971981 Diablo homolog, mitochondrial Precursor (Second mitochondria-derived activator of caspase)(Smac protein)(Direct IAP-binding protein with low pI) [Source:UniProtKB/Swiss-Prot;Acc:Q9JIQ3]
CASP2 CASPASE 2, CASPASE-2, ICH-1, NEDD2 Mouse CASPASE APOPTOSIS 7958843,19581929 caspase 2 Gene [Source:MGI (curated);Acc:Casp2-001] The role of caspase-2 during apoptosis is still under debate
TNFRSF1A TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A, CD120A, P55, P55-R, TNF RECEPTOR ALPHA CHAIN, TNF-ALPHA-R1, TNF-ALPHAR1, TNF-R-I, TNF-R1, TNF-R55, TNFALPHA-R1, TNFAR, TNFR-2, TNFR1, TNFR60, TNFRI, TNFRP55 Mouse DEATH RECEPTOR APOPTOSIS,NECROPTOSIS EXTRINSIC PATHWAY,TNF/NF-KAPPAB SIGNALING 1645445,1718003 Tumor necrosis factor receptor superfamily member 1A Precursor (p60)(TNF-R1)(TNF-RI)(TNFR-I)(p55)(CD120a antigen) [Source:UniProtKB/Swiss-Prot;Acc:P25118]
FADD FADD, FAS (TNFRSF6)-ASSOCIATED VIA DEATH DOMAIN Mouse DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN,DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN;DED ADAPTER PROTEIN APOPTOSIS EXTRINSIC PATHWAY 9521326 Protein FADD (FAS-associated death domain protein)(FAS-associating death domain-containing protein)(Mediator of receptor induced toxicity) [Source:UniProtKB/Swiss-Prot;Acc:Q61160]
CASP3 CASPASE 3, A830040C14RIK, APOPAIN, CASPASE-3, CC3, CPP32, YAMA Mouse CASPASE APOPTOSIS EXTRINSIC PATHWAY,INTRINSIC PATHWAY,POST-MITOCHONDRIAL CASPASE ACTIVATION 8934524 caspase 3 Gene [Source:MGI Symbol;Acc:MGI:107739]
TRADD TRADD, TNFRSF1A-ASSOCIATED VIA DEATH DOMAIN Mouse DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN APOPTOSIS EXTRINSIC PATHWAY,TNF/NF-KAPPAB SIGNALING 7758105 Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein)(TNFRSF1A-associated via death domain) [Source:UniProtKB/Swiss-Prot;Acc:Q3U0V2]
CIAP2 BIRC3, API2, CIAP-2, CIAP2, HIAP2, IAP2, MIAP2, MIHC, RNF49 Mouse BIR-CONTAINING PROTEIN;IAP IMMUNITY TNF/NF-KAPPAB SIGNALING 19464198,8548810 baculoviral IAP repeat-containing 3 Gene
BCL2L10 BCL2L10, BCL2-LIKE 10, BOO, DIVA Mouse BCL-2 FAMILY;MULTIDOMAIN BCL-2 UNDEFINED UNDEFINED 9878060,12215543 Bcl2-like 10 Gene [Source:MGI Symbol;Acc:MGI:1330841] The role of this protein during cell death requires further clarification.
NLRP3 NLRP3, NLR FAMILY, PYRIN DOMAIN CONTAINING 3 Mouse OTHER IMMUNITY INFLAMMASOME 12563287,15952891 NACHT, LRR and PYD domains-containing protein 3 (Cold autoinflammatory syndrome 1 protein homolog)(Cryopyrin)(PYRIN-containing APAF1-like protein 1)(Mast cell maturation-associated-inducible protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q8R4B8]
CASP4 CASPASE 4, CASP11, CASPASE-11, ICH-3 Mouse CASPASE IMMUNITY INFLAMMASOME 9491891 caspase 4, apoptosis-related cysteine peptidase Gene [Source:MGI Symbol;Acc:MGI:107700]
PARP2 PARP2, POLY (ADP-RIBOSE) POLYMERASE FAMILY, MEMBER 2 Mouse OTHER NECROPTOSIS 10364231,19109899 poly (ADP-ribose) polymerase family, member 2 Gene [Source:MGI Symbol;Acc:MGI:1341112]
CYLD CYLD, CYLINDROMATOSIS (TURBAN TUMOR SYNDROME) Mouse OTHER NECROPTOSIS TNF/NF-KAPPAB SIGNALING 19109899 cylindromatosis (turban tumor syndrome) Gene [Source:MGI Symbol;Acc:MGI:1921506]
AIFM1 AIFM1, APOPTOSIS-INDUCING FACTOR, MITOCHONDRION-ASSOCIATED 1, AIF, PDCD8 Mouse OTHER CELL DEATH (OTHER) 16788063,15526035 apoptosis-inducing factor, mitochondrion-associated 1 Gene [Source:MGI (curated);Acc:Aifm1-001]
TNFRSF23 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 23, MDCTRAILR1, MSOB, TNFRH1 Mouse DEATH RECEPTOR UNDEFINED UNDEFINED 18079962,10383128,12466268,19476510 Tumor necrosis factor receptor superfamily member 23 Precursor (Tumor necrosis factor receptor p60 homolog 1)(TNF receptor family member SOB)(Decoy TRAIL receptor 1)(TNF receptor homolog 1) [Source:UniProtKB/Swiss-Prot;Acc:Q9ER63]
MCL1 MCL1, MYELOID CELL LEUKEMIA SEQUENCE 1 Mouse BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 9002967,19127517 Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Bcl-2-related protein EAT/mcl1) [Source:UniProtKB/Swiss-Prot;Acc:P97287]
TRAIL TNFSF10, TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY MEMBER 10, APO-2L, TRAIL Mouse DEATH LIGAND APOPTOSIS EXTRINSIC PATHWAY 12209637 Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand)(Protein TRAIL)(CD253 antigen)
BMF BMF, BCL2 MODIFYING FACTOR Mouse BCL-2 FAMILY;BH3-ONLY APOPTOSIS,NECROPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 19109899,11546872 BCL2 modifying factor Gene [Source:MGI (curated);Acc:Bmf-001]
DP5 HRK, HARAKIRI, BCL2 INTERACTING PROTEIN (CONTAINS ONLY BH3 DOMAIN) Mouse BCL-2 FAMILY;BH3-ONLY APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 17535852,9130713 Activator of apoptosis harakiri (Neuronal death protein DP5)(BH3-interacting domain-containing protein 3) [Source:UniProtKB/Swiss-Prot;Acc:P62816]
BCL2 BCL2, B-CELL LEUKEMIA/LYMPHOMA 2 Mouse BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 3032455 B-cell leukemia/lymphoma 2 Gene [Source:MGI (curated);Acc:Bcl2-001]
CIAP1 BIRC2, API1, CIAP-1, CIAP1, HIAP1, IAP1, MCIAP1, MIAP1, MIHB, BIRC2, BACULOVIRAL IAP REPEAT-CONTAINING 2 Mouse BIR-CONTAINING PROTEIN;IAP IMMUNITY TNF/NF-KAPPAB SIGNALING 19464198,8548810 baculoviral IAP repeat-containing 2 Gene
BAK1 BCL2-ANTAGONIST/KILLER 1, BAK, N-BAK Mouse BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 11326099,9299236 BCL2-antagonist/killer 1 Gene [Source:MGI (curated);Acc:Bak1-001]
TRP53 TP53, P53, TUMOR SUPPRESSOR P53, TRP53, CELLULAR TUMOR ANTIGEN P53 Mouse OTHER APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 19410540,8353276 transformation related protein 53 Gene [Source:MGI (curated);Acc:Trp53-001] Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.
CYCS CYCS, CYTOCHROME C, SOMATIC Mouse OTHER APOPTOSIS EXTRINSIC PATHWAY,INTRINSIC PATHWAY,POST-MITOCHONDRIAL CASPASE ACTIVATION 15907471 Cytochrome c, somatic [Source:UniProtKB/Swiss-Prot;Acc:P62897]
NLRP1A NLRP1A, NLR FAMILY, PYRIN DOMAIN CONTAINING 1A Mouse CARD-CONTAINING PROTEIN;CARD ADAPTER PROTEIN IMMUNITY INFLAMMASOME 12563287,15952891 NLR family, pyrin domain containing 1A [Source:RefSeq peptide;Acc:NP_001004142]
BCL2A1A BCL2A1A, B-CELL LEUKEMIA/LYMPHOMA 2 RELATED PROTEIN A1A, A1, BCL2A1, BFL-1, HBPA1 Mouse BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS INTRINSIC PATHWAY,PRE-MITOCHONDRIAL SIGNALING EVENTS 8345191 Bcl-2-related protein A1 (Protein BFL-1)(Hemopoietic-specific early response protein)(A1-A) [Source:UniProtKB/Swiss-Prot;Acc:Q07440]
BNIP3 BNIP3, BCL2/ADENOVIRUS E1B INTERACTING PROTEIN 3 Mouse BCL-2 FAMILY;BH3-ONLY CELL DEATH (OTHER),APOPTOSIS INTRINSIC PATHWAY 19641497,9575197 BCL2/adenovirus E1B interacting protein 3 Gene [Source:MGI (curated);Acc:Bnip3-001]
CED-8 Worm OTHER APOPTOSIS 10882128 The ced-8 gene encodes a homolog of the human putative membrane transporter XK. ced-8 is required for apoptosis to occur with normal speed during embryonic development. [Source: WormBase]
EGL-1 Worm BCL-2 FAMILY;BH3-ONLY APOPTOSIS 9604928 egl-1 encodes a novel protein that contains a region similar to the BH3 (Bcl-2 homology region 3) domain of mammalian cell death activators. EGL-1 functions as an upstream activator in the general programmed cell death pathway and positively regulates programmed cell death by interacting directly with CED-9 to induce CED-4 release from CED-4/CED-9 complexes and ultimately activate the CED-3 caspase. EGL-1 also induces WAH-1/apoptosis-inducing factor release from the mitochondria. in hermaphrodites, egl-1 is transcriptionally repressed by TRA-1, permitting survival of the HSN neurons required for egg laying. egl-1 message is detected at low abundance in embryonic and L1 larval mRNA preparations, but not in mRNA preparations from later larval stages or young adults. [Source: WormBase]
CEP-1 TRANSCRIPTION FACTOR CEP-1, C.ELEGANS P53-LIKE PROTEIN 1 Worm OTHER UNDEFINED UNDEFINED 11557844,11696333 Ancestral member of the p53 family (p53, p63, p73) Promotes DNA damage-induced apoptosis and is required for normal meiotic segregation in the C. elegans germ line. Affects sensitivity to hypoxia-induced lethality and longevity in response to starvation. Implicated in autophagy. Expressed in the germ line and during embryogenesis.
BSK JNK, STRESS-ACTIVATED PROTEIN KINASE JNK Fly OTHER CELL DEATH (OTHER) 8946915,10408443 NA
TH IAP1,INHIBITOR OF APOPTOSIS 1, THREAD Fly BIR-CONTAINING PROTEIN;IAP APOPTOSIS 8548811 NA
W CELL DEATH PROTEIN W, PROTEIN HEAD INVOLUTION DEFECTIVE, PROTEIN WRINKLED, HID Fly IAP ANTAGONIST APOPTOSIS 7622034 NA
CRC CALRETICULIN Fly OTHER; APOPTOSIS APOPTOTIC CELL CLEARANCE 17137576,19291407 Calreticulin
DCP-1 CASPASE-1, CASPASE-1 SUBUNIT P22, CASPASE-1 SUBUNIT P13 Fly CASPASE APOPTOSIS 8999799 NA
ATG1 Fly OTHER; CELL DEATH (OTHER) 19818615,18083103 Autophagy-specific gene 1 This protein participates in autophagic cell death during Drosophila development.
RPR CELL DEATH PROTEIN RPR, REAPER Fly IAP ANTAGONIST APOPTOSIS 8171319 NA
IMD IMMUNE DEFICIENCY, BG5 Fly DEATH DOMAIN-CONTAINING PROTEIN;OTHER IMMUNITY 1132328 NA
IAP2 APOPTOSIS 2 INHIBITOR, INHIBITOR OF APOPTOSIS 2, DIAP2, DIAP, IAP HOMOLOG A, DIHA, ILP Fly BIR-CONTAINING PROTEIN;IAP IMMUNITY,APOPTOSIS 16894030,18166655 NA
GRIM Fly IAP ANTAGONIST APOPTOSIS 8698237 NA
ICE DRICE, CASPASE SUBUNIT P21, CASPASE SUBUNIT P12 Fly CASPASE APOPTOSIS 9184225 NA
DREDD CASPASE-8, CASPASE-8 SUBUNIT P15, CASPASE-8 SUBUNIT P10, DCP2 Fly CASPASE IMMUNITY TNF/NF-KAPPAB SIGNALING 9740659 NA
ARK APAF-1 RELATED KILLER DARK, APAF-1/CED-4-RELATED CASPASE ACTIVATOR DAPAF-1L, CELL DEATH PROTEIN HAC-1, HAC1, DAPAF-1L Fly CARD-CONTAINING PROTEIN;CARD ADAPTER PROTEIN APOPTOSIS 10559939 NA
TRAF2 TNF-RECEPTOR-ASSOCIATED FACTOR 6, TRAF6 Fly OTHER CELL DEATH (OTHER) TNF/NF-KAPPAB SIGNALING 12894227 NA
TRAF1 TNF-RECEPTOR-ASSOCIATED FACTOR 4, TRAF4 Fly OTHER CELL DEATH (OTHER) TNF/NF-KAPPAB SIGNALING 10766844,12198495 NA
NC DRONC, CASPASE NC, NEDD2-LIKE CASPASE DRONC, CASPASE NC SUBUNIT 1, CASPASE NC SUBUNIT 2 Fly CASPASE APOPTOSIS 10200258,10675329 NA
DRPR DRAPER Fly OTHER APOPTOSIS APOPTOTIC CELL CLEARANCE 15342648,16772169,19291407 draper
DECAY DEATH EXECUTIONER CASPASE RELATED TO APOPAIN/YAMA, CASPASE 6-LIKE PROTEIN BG2 Fly CASPASE APOPTOSIS 10521468,16485033 NA
DEBCL Fly BCL-2 FAMILY;MULTIDOMAIN BCL-2 CELL DEATH (OTHER) 10684252,19088092 NA
WGN WENGEN, TNFR SUPERFAMILY PROTEIN WENGEN, VADER Fly DEATH RECEPTOR CELL DEATH (OTHER) TNF/NF-KAPPAB SIGNALING 12084706 NA
DREAM STRICA Fly CASPASE APOPTOSIS 11550090,16485033 NA
EGR EIGER Fly DEATH LIGAND CELL DEATH (OTHER) TNF/NF-KAPPAB SIGNALING 12065414 NA
DAMM DEATH ASSOCIATED MOLECULE RELATED TO MCH2, DAYDREAM Fly CASPASE 11337486 NA Ectopic expression of DAMM induces apoptosis [Pubmed Link: 11337486]
HIPK HIPK, HOMEODOMAIN INTERACTING PROTEIN KINASE Fly OTHER CELL DEATH (OTHER) 17682052 NA
ATG18 Fly OTHER; CELL DEATH (OTHER) 19818615,18083103 Autophagy-specific gene 18 This protein participates in autophagic cell death during Drosophila development.
ARD1 ARREST DEFECTIVE 1 Fly OTHER APOPTOSIS 17998402 NA
SKL SICKLE, IAP-INHIBITORY PROTEIN SICKLE Fly IAP ANTAGONIST APOPTOSIS 11818063 NA
BRUCE BIR-CONTAINING UBIQUITIN-CONJUGATING ENZYME Fly BIR-CONTAINING PROTEIN;IAP CELL DEATH (OTHER) 12121627 NA
HTRA2 OMI, SERINE PROTEASE HTRA2 Fly OTHER APOPTOSIS 17557079,17397804 NA
BG4 DEATH DOMAIN-CONTAINING ADAPTER PROTEIN BG4, FAS-ASSOCIATED DEATH DOMAIN-CONTAINING PROTEIN Fly DEATH DOMAIN-CONTAINING PROTEIN;DD ADAPTER PROTEIN IMMUNITY TNF/NF-KAPPAB SIGNALING 10934188,12433364,12123572 NA
JAFRAC2 THIOREDOXIN PEROXIDASE 2, GH25379P, SECRETABLE THIOREDOXIN PEROXIDASE Fly IAP ANTAGONIST APOPTOSIS 12356728 NA
BUFFY Fly BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS 12853472 NA
ATG2 Fly OTHER; CELL DEATH (OTHER) 19818615,18083103 Autophagy-specific gene 2 This protein participates in autophagic cell death during Drosophila development.
ATG8A Fly OTHER; CELL DEATH (OTHER) 18083103 Autophagy-specific gene 8a This protein participates in autophagic cell death during Drosophila development.
CYT-C-D CYTOCHROME C-1, CYTOCHROME C-DISTAL, CYTC1, DC3 Fly OTHER 18451868,12737804,10037791 NA The role of cytochrome c on apoptosis in Drosophila is still unclear since there is not a classical mitochondrial pathway. However, cyt.c seems to participate in apoptosis of some cell types [Pubmed Link: 12737804]
CED-9 Worm BCL-2 FAMILY;MULTIDOMAIN BCL-2 APOPTOSIS 1560823 ced-9 encodes the sole C. elegans homolog of the mammalian cell-death inhibitor Bcl-2. during development, CED-9 activity is essential for preventing cells from undergoing programmed cell death and CED-9 functions by binding and repressing the activity of CED-4, a protein similar to human APAF-1 that positively regulates CED-3 caspase activity. CED-9 localizes to mitochondria. [Source: WormBase]
CED-1 Worm OTHER; APOPTOSIS APOPTOTIC CELL CLEARANCE 11163239,15642378 The ced-1 gene encodes a transmembrane protein on phagocytic cells that is homologous to human CD91, a low density lipoprotein receptor paralog. the cytoplasmic tail of CED-1 contains two motifs important for engulfment. [Source: WormBase] CED-1 is a transmembrane receptor, similar to CD91/LRP scavenger receptors.
CSP-3 Worm CASPASE APOPTOSIS 18776901 csp-3 encodes a protein that is homologous to the C-terminal domain of caspase-like cysteine proteases. unlike other caspases, CSP-3 does not contain a middle or N-terminal domain, and thus may either function in concert with the middle domains of other caspases or may play a regulatory (dominant negative) role in caspase activation. [Source: WormBase] This protein is highly homologous to Ced-3 and can inhibit its autoactivation
WAH-1 Worm OTHER APOPTOSIS 12446902 wah-1 encodes a putative flavin-adenine dinucleotide (FAD)-binding oxidoreductase orthologous to mammalian PDCD8 (AIF. OMIM:300169, mutated in Harlequin mice). WAH-1 is required for apoptotic DNA degratation, SCRM-1 phospholipid scramblase activity, phosphatidylserine exposure, rapid apoptosis during embryonic development, and rapid engulfment of apoptotic cells in the germline. WAH-1 is also required for normally rapid growth and large brood sizes, and has a subtle proapoptotic function revealed in ced-3 or ced-4 mutant backgrounds. WAH-1 is expressed in most, if not all, cells of embryos and larvae. WAH-1 is normally mitochondrial, but can be released into the cytosol and nucleus by EGL-1 and CED-3. residues 380-550 of WAH-1 specifically bind SCRM-1 in vitro, but not SCRM-2 through SCRM-4, and WAH-1 binding is required in liposomes for more than residual SCRM-1 activity. WAH-1 also binds and activates CPS-6, promoting apoptotic DNA degradation, and transgenic coexpression of WAH-1 with CPS-6 specifically induces ectopic CED-3-dependent apoptosis in touch receptor neurons. CPS-6 shares a genetic pathway with WAH-1, whereas CED-3, CED-4, CED-8, and NUC-1 act independently of it. WAH-1 is paralogous to C. elegans F20D6.11 and human AIFM3 (AIFL). [Source: WormBase]
NEX-1 Worm OTHER; APOPTOSIS APOPTOTIC CELL CLEARANCE 12689596,15642378 nex-1 encodes an annexin, a member of a family of calcium-dependent phospholipid binding proteins. NEX-1 is required for efficient engulfment of apoptotic cell corpses in the pharynx, and may also function in other membrane fusion events, such as exocytosis. NEX-1 in vitro can bind phosphatidylserine, phosphatidylinositol, heparin, heparan sulfate, and chondroitin sulfate. NEX-1 is expressed in the pharynx, hypodermal cells, the vulva, the uterus, the spermathecal valve, and yolk granules of maturing oocytes. [Source: WormBase]